Details of the Target

General Information of Target

Target ID LDTP03250
Target Name Inositol-trisphosphate 3-kinase A (ITPKA)
Gene Name ITPKA
Gene ID 3706
Synonyms
Inositol-trisphosphate 3-kinase A; EC 2.7.1.127; Inositol 1,4,5-trisphosphate 3-kinase A; IP3 3-kinase A; IP3K A; InsP 3-kinase A
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MTLPGGPTGMARPGGARPCSPGLERAPRRSVGELRLLFEARCAAVAAAAAAGEPRARGAK
RRGGQVPNGLPRAPPAPVIPQLTVTAEEPDVPPTSPGPPERERDCLPAAGSSHLQQPRRL
STSSVSSTGSSSLLEDSEDDLLSDSESRSRGNVQLEAGEDVGQKNHWQKIRTMVNLPVIS
PFKKRYAWVQLAGHTGSFKAAGTSGLILKRCSEPERYCLARLMADALRGCVPAFHGVVER
DGESYLQLQDLLDGFDGPCVLDCKMGVRTYLEEELTKARERPKLRKDMYKKMLAVDPEAP
TEEEHAQRAVTKPRYMQWREGISSSTTLGFRIEGIKKADGSCSTDFKTTRSREQVLRVFE
EFVQGDEEVLRRYLNRLQQIRDTLEVSEFFRRHEVIGSSLLFVHDHCHRAGVWLIDFGKT
TPLPDGQILDHRRPWEEGNREDGYLLGLDNLIGILASLAER
Target Bioclass
Enzyme
Family
Inositol phosphokinase (IPK) family
Subcellular location
Cytoplasm, cytoskeleton
Function Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis.
Uniprot ID
P23677
Ensemble ID
ENST00000260386.7
HGNC ID
HGNC:6178
ChEMBL ID
CHEMBL5164

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C19(0.00); C105(0.00); C42(0.00)  LDD0241  [1]
DBIA
 Probe Info  		C342(1.10)  LDD0531  [2]
NAIA_4
 Probe Info  		N.A.  LDD2226  [3]
TFBX
 Probe Info  		N.A.  LDD0027  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C342(1.10)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C342(1.06)  LDD0532  [2]
 LDCM0226  AC11 HCT 116 C342(1.10)  LDD0543  [2]
 LDCM0230  AC113 HCT 116 C342(0.88)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C342(1.16)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C342(1.51)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C342(2.46)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C342(1.38)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C342(1.78)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C342(1.94)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C342(1.11)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C342(1.74)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C342(1.28)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C342(1.31)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C342(1.02)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C342(1.13)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C342(1.64)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C342(2.32)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C342(2.55)  LDD0562  [2]
 LDCM0259  AC14 HCT 116 C342(0.82)  LDD0576  [2]
 LDCM0270  AC15 HCT 116 C342(0.92)  LDD0587  [2]
 LDCM0276  AC17 HCT 116 C342(1.12)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C342(2.47)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C342(1.13)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C342(1.09)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C342(1.35)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C342(1.39)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C342(1.11)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C342(1.36)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C342(0.89)  LDD0601  [2]
 LDCM0286  AC26 HEK-293T C105(1.06); C42(1.16)  LDD1525  [5]
 LDCM0287  AC27 HEK-293T C105(1.11)  LDD1526  [5]
 LDCM0288  AC28 HEK-293T C42(1.24)  LDD1527  [5]
 LDCM0289  AC29 HEK-293T C105(0.87); C342(1.02)  LDD1528  [5]
 LDCM0290  AC3 HCT 116 C342(1.03)  LDD0607  [2]
 LDCM0291  AC30 HEK-293T C42(1.08); C342(0.98); C19(0.96)  LDD1530  [5]
 LDCM0292  AC31 HEK-293T C342(1.04)  LDD1531  [5]
 LDCM0293  AC32 HEK-293T C105(1.13); C42(1.17)  LDD1532  [5]
 LDCM0295  AC34 HEK-293T C105(1.20); C42(1.01)  LDD1534  [5]
 LDCM0296  AC35 HEK-293T C105(0.89)  LDD1535  [5]
 LDCM0297  AC36 HEK-293T C42(0.97)  LDD1536  [5]
 LDCM0298  AC37 HEK-293T C105(1.09); C342(1.06)  LDD1537  [5]
 LDCM0299  AC38 HEK-293T C42(1.01); C342(1.13); C19(1.13)  LDD1538  [5]
 LDCM0300  AC39 HEK-293T C342(1.06)  LDD1539  [5]
 LDCM0301  AC4 HCT 116 C342(1.07)  LDD0618  [2]
 LDCM0302  AC40 HEK-293T C105(1.16); C42(1.19)  LDD1541  [5]
 LDCM0304  AC42 HEK-293T C105(1.76); C42(1.20)  LDD1543  [5]
 LDCM0305  AC43 HEK-293T C105(1.10)  LDD1544  [5]
 LDCM0306  AC44 HEK-293T C42(0.93)  LDD1545  [5]
 LDCM0307  AC45 HEK-293T C105(1.10); C342(1.07)  LDD1546  [5]
 LDCM0308  AC46 HEK-293T C42(1.26); C342(1.08); C19(0.97)  LDD1547  [5]
 LDCM0309  AC47 HEK-293T C342(1.10)  LDD1548  [5]
 LDCM0310  AC48 HEK-293T C105(1.06); C42(1.27)  LDD1549  [5]
 LDCM0312  AC5 HCT 116 C342(1.05)  LDD0629  [2]
 LDCM0313  AC50 HEK-293T C105(1.19); C42(1.14)  LDD1552  [5]
 LDCM0314  AC51 HEK-293T C105(1.02)  LDD1553  [5]
 LDCM0315  AC52 HEK-293T C42(1.24)  LDD1554  [5]
 LDCM0316  AC53 HEK-293T C105(0.86); C342(1.07)  LDD1555  [5]
 LDCM0317  AC54 HEK-293T C42(1.06); C342(1.07); C19(0.97)  LDD1556  [5]
 LDCM0318  AC55 HEK-293T C342(1.16)  LDD1557  [5]
 LDCM0319  AC56 HEK-293T C105(1.07); C42(1.36)  LDD1558  [5]
 LDCM0321  AC58 HEK-293T C105(1.11); C42(1.15)  LDD1560  [5]
 LDCM0322  AC59 HEK-293T C105(1.05)  LDD1561  [5]
 LDCM0323  AC6 HCT 116 C342(0.96)  LDD0640  [2]
 LDCM0324  AC60 HEK-293T C42(1.13)  LDD1563  [5]
 LDCM0325  AC61 HEK-293T C105(0.81); C342(1.06)  LDD1564  [5]
 LDCM0326  AC62 HEK-293T C42(1.31); C342(1.03); C19(0.85)  LDD1565  [5]
 LDCM0327  AC63 HEK-293T C342(0.97)  LDD1566  [5]
 LDCM0328  AC64 HEK-293T C105(1.26); C42(1.19)  LDD1567  [5]
 LDCM0334  AC7 HCT 116 C342(1.01)  LDD0651  [2]
 LDCM0345  AC8 HCT 116 C342(1.15)  LDD0662  [2]
 LDCM0248  AKOS034007472 HCT 116 C342(1.00)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C342(1.01)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C342(1.15)  LDD0592  [2]
 LDCM0367  CL1 HEK-293T C105(1.26)  LDD1571  [5]
 LDCM0368  CL10 HEK-293T C42(1.76); C342(1.11); C19(1.44)  LDD1572  [5]
 LDCM0369  CL100 HCT 116 C342(0.97)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C342(0.93)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C342(0.95)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C342(1.04)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C342(0.98)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C342(1.45)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C342(1.91)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C342(2.23)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C342(1.76)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C342(1.62)  LDD0695  [2]
 LDCM0379  CL11 HEK-293T C342(1.24)  LDD1583  [5]
 LDCM0380  CL110 HCT 116 C342(1.22)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C342(1.21)  LDD0698  [2]
 LDCM0382  CL112 HEK-293T C105(0.92); C42(0.84); C19(0.97)  LDD1586  [5]
 LDCM0383  CL113 HEK-293T C105(1.10)  LDD1587  [5]
 LDCM0384  CL114 HEK-293T C105(1.24); C42(1.48)  LDD1588  [5]
 LDCM0385  CL115 HEK-293T C342(1.04)  LDD1589  [5]
 LDCM0386  CL116 HEK-293T C105(0.86); C42(1.18); C19(1.08)  LDD1590  [5]
 LDCM0387  CL117 HEK-293T C105(0.72)  LDD1591  [5]
 LDCM0388  CL118 HEK-293T C105(1.15); C42(1.10)  LDD1592  [5]
 LDCM0389  CL119 HEK-293T C342(1.05)  LDD1593  [5]
 LDCM0390  CL12 HEK-293T C105(1.25); C42(1.60)  LDD1594  [5]
 LDCM0391  CL120 HEK-293T C105(1.10); C42(1.01); C19(0.84)  LDD1595  [5]
 LDCM0392  CL121 HEK-293T C105(1.37)  LDD1596  [5]
 LDCM0393  CL122 HEK-293T C105(0.98); C42(1.17)  LDD1597  [5]
 LDCM0394  CL123 HEK-293T C342(1.03)  LDD1598  [5]
 LDCM0395  CL124 HEK-293T C105(0.76); C42(1.17); C19(0.96)  LDD1599  [5]
 LDCM0396  CL125 HEK-293T C105(0.74)  LDD1600  [5]
 LDCM0397  CL126 HEK-293T C105(0.98); C42(1.00)  LDD1601  [5]
 LDCM0398  CL127 HEK-293T C342(1.07)  LDD1602  [5]
 LDCM0399  CL128 HEK-293T C105(0.75); C42(0.95); C19(0.78)  LDD1603  [5]
 LDCM0400  CL13 HEK-293T C105(1.05)  LDD1604  [5]
 LDCM0401  CL14 HEK-293T C105(1.07); C42(1.22)  LDD1605  [5]
 LDCM0402  CL15 HEK-293T C342(1.02)  LDD1606  [5]
 LDCM0403  CL16 HEK-293T C105(0.95); C42(1.15); C19(1.19)  LDD1607  [5]
 LDCM0405  CL18 HEK-293T C105(1.44); C42(1.21)  LDD1609  [5]
 LDCM0406  CL19 HEK-293T C105(1.20)  LDD1610  [5]
 LDCM0407  CL2 HEK-293T C105(1.13); C42(1.20)  LDD1611  [5]
 LDCM0408  CL20 HEK-293T C42(1.10)  LDD1612  [5]
 LDCM0409  CL21 HEK-293T C105(1.68); C342(1.10)  LDD1613  [5]
 LDCM0410  CL22 HEK-293T C42(1.34); C342(1.41); C19(1.63)  LDD1614  [5]
 LDCM0411  CL23 HEK-293T C342(1.22)  LDD1615  [5]
 LDCM0412  CL24 HEK-293T C105(1.64); C42(1.72)  LDD1616  [5]
 LDCM0413  CL25 HEK-293T C105(1.04)  LDD1617  [5]
 LDCM0414  CL26 HEK-293T C105(0.73); C42(1.04)  LDD1618  [5]
 LDCM0415  CL27 HEK-293T C342(1.06)  LDD1619  [5]
 LDCM0416  CL28 HEK-293T C105(0.78); C42(1.12); C19(0.84)  LDD1620  [5]
 LDCM0418  CL3 HEK-293T C342(1.05)  LDD1622  [5]
 LDCM0419  CL30 HEK-293T C105(1.12); C42(1.26)  LDD1623  [5]
 LDCM0420  CL31 HCT 116 C342(0.81)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C342(0.98)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C342(1.26)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C342(1.13)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C342(0.85)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C342(0.89)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C342(0.94)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C342(0.98)  LDD0745  [2]
 LDCM0429  CL4 HEK-293T C105(0.77); C42(1.24); C19(0.92)  LDD1633  [5]
 LDCM0430  CL40 HCT 116 C342(0.82)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C342(0.84)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C342(0.96)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C342(1.03)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C342(0.96)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C342(0.91)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C342(1.40)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C342(0.96)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C342(1.02)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C342(1.24)  LDD0756  [2]
 LDCM0441  CL50 HCT 116 C342(1.06)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C342(1.37)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C342(1.25)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C342(0.77)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C342(1.14)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C342(1.09)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C342(0.94)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C342(0.92)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C342(1.09)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C342(1.15)  LDD0767  [2]
 LDCM0451  CL6 HEK-293T C105(0.98); C42(1.50)  LDD1654  [5]
 LDCM0452  CL60 HCT 116 C342(1.30)  LDD0769  [2]
 LDCM0453  CL61 HEK-293T C105(1.03)  LDD1656  [5]
 LDCM0454  CL62 HEK-293T C105(1.06); C42(1.01)  LDD1657  [5]
 LDCM0455  CL63 HEK-293T C342(1.09)  LDD1658  [5]
 LDCM0456  CL64 HEK-293T C105(0.68); C42(1.13); C19(0.83)  LDD1659  [5]
 LDCM0458  CL66 HEK-293T C105(1.03); C42(1.22)  LDD1661  [5]
 LDCM0459  CL67 HEK-293T C105(1.17)  LDD1662  [5]
 LDCM0460  CL68 HEK-293T C42(1.19)  LDD1663  [5]
 LDCM0461  CL69 HEK-293T C105(1.06); C342(1.15)  LDD1664  [5]
 LDCM0462  CL7 HEK-293T C105(0.91)  LDD1665  [5]
 LDCM0463  CL70 HEK-293T C42(1.41); C342(1.30); C19(1.32)  LDD1666  [5]
 LDCM0464  CL71 HEK-293T C342(1.28)  LDD1667  [5]
 LDCM0465  CL72 HEK-293T C105(1.62); C42(1.34)  LDD1668  [5]
 LDCM0466  CL73 HEK-293T C105(1.28)  LDD1669  [5]
 LDCM0467  CL74 HEK-293T C105(1.00); C42(1.06)  LDD1670  [5]
 LDCM0469  CL76 HEK-293T C105(1.05); C42(0.87); C19(0.80)  LDD1672  [5]
 LDCM0471  CL78 HEK-293T C105(1.22); C42(1.40)  LDD1674  [5]
 LDCM0472  CL79 HEK-293T C105(0.93)  LDD1675  [5]
 LDCM0473  CL8 HEK-293T C42(1.18)  LDD1676  [5]
 LDCM0474  CL80 HEK-293T C42(1.02)  LDD1677  [5]
 LDCM0475  CL81 HEK-293T C105(1.01); C342(1.22)  LDD1678  [5]
 LDCM0476  CL82 HEK-293T C42(1.40); C342(1.02); C19(1.49)  LDD1679  [5]
 LDCM0477  CL83 HEK-293T C342(1.08)  LDD1680  [5]
 LDCM0478  CL84 HEK-293T C105(1.66); C42(1.49)  LDD1681  [5]
 LDCM0479  CL85 HEK-293T C105(0.92)  LDD1682  [5]
 LDCM0480  CL86 HEK-293T C105(0.88); C42(1.14)  LDD1683  [5]
 LDCM0481  CL87 HEK-293T C342(0.96)  LDD1684  [5]
 LDCM0482  CL88 HEK-293T C105(0.75); C42(1.01); C19(0.87)  LDD1685  [5]
 LDCM0484  CL9 HEK-293T C105(1.15); C342(1.15)  LDD1687  [5]
 LDCM0485  CL90 HEK-293T C105(1.21); C42(1.49)  LDD1688  [5]
 LDCM0486  CL91 HCT 116 C342(1.33)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C342(1.09)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C342(0.99)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C342(0.84)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C342(1.11)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C342(1.03)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C342(1.11)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C342(1.15)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C342(1.20)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C342(1.12)  LDD1698  [5]
 LDCM0468  Fragment33 HEK-293T C342(1.11)  LDD1671  [5]
 LDCM0427  Fragment51 HCT 116 C342(0.69)  LDD0744  [2]
 LDCM0022  KB02 HEK-293T C105(1.16); C342(1.04)  LDD1492  [5]
 LDCM0023  KB03 HEK-293T C105(1.12); C342(1.03)  LDD1497  [5]
 LDCM0024  KB05 UACC257 C230(1.04)  LDD3325  [6]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
1d-myo-inositol 145-trisphosphate Small molecular drug DB03401
Inositol 1345-tetrakisphosphate Small molecular drug DB01863
Phosphoaminophosphonic Acid-adenylate Ester . DB04395

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840