Details of the Target

General Information of Target

Target ID LDTP02741
Target Name Small nuclear ribonucleoprotein-associated proteins B and B' (SNRPB)
Gene Name SNRPB
Gene ID 6628
Synonyms
COD; SNRPB1; Small nuclear ribonucleoprotein-associated proteins B and B'; snRNP-B; Sm protein B/B'; Sm-B/B'; SmB/B'
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTVGKSSKMLQHIDYRMRCILQDGRIFIGTFKAFDKHMNLILCDCDEFRKIKPKNSKQAE
REEKRVLGLVLLRGENLVSMTVEGPPPKDTGIARVPLAGAAGGPGIGRAAGRGIPAGVPM
PQAPAGLAGPVRGVGGPSQQVMTPQGRGTVAAAAAAATASIAGAPTQYPPGRGGPPPPMG
RGAPPPGMMGPPPGMRPPMGPPMGIPPGRGTPMGMPPPGMRPPPPGMRGPPPPGMRPPRP
Target Bioclass
Other
Family
SnRNP SmB/SmN family
Subcellular location
Cytoplasm, cytosol
Function
Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing.
Uniprot ID
P14678
Ensemble ID
ENST00000381342.7
HGNC ID
HGNC:11153

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
A-EBA
 Probe Info  		4.69  LDD0215  [1]
Probe 1
 Probe Info  		Y15(29.83)  LDD3495  [2]
m-APA
 Probe Info  		12.08  LDD0403  [3]
BTD
 Probe Info  		C19(1.05)  LDD1700  [4]
DBIA
 Probe Info  		C19(6.58); C43(4.66); C45(4.66)  LDD0209  [5]
HHS-475
 Probe Info  		Y15(0.80)  LDD0264  [6]
5E-2FA
 Probe Info  		N.A.  LDD2235  [7]
ATP probe
 Probe Info  		K36(0.00); K88(0.00)  LDD0199  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C19(0.00); C43(0.00); C45(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [10]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [11]
Lodoacetamide azide
 Probe Info  		C19(0.00); C43(0.00); C45(0.00)  LDD0037  [9]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [12]
NAIA_4
 Probe Info  		N.A.  LDD2226  [13]
TFBX
 Probe Info  		N.A.  LDD0027  [12]
WYneN
 Probe Info  		N.A.  LDD0021  [14]
IPM
 Probe Info  		N.A.  LDD0005  [14]
NHS
 Probe Info  		N.A.  LDD0010  [14]
NPM
 Probe Info  		N.A.  LDD0016  [14]
PPMS
 Probe Info  		N.A.  LDD0008  [14]
SF
 Probe Info  		N.A.  LDD0028  [15]
STPyne
 Probe Info  		N.A.  LDD0009  [14]
1c-yne
 Probe Info  		N.A.  LDD0228  [16]
NAIA_5
 Probe Info  		C45(0.00); C43(0.00); C19(0.00)  LDD2223  [13]
HHS-465
 Probe Info  		N.A.  LDD2240  [17]
HHS-482
 Probe Info  		Y15(0.94)  LDD2239  [18]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DA-2
 Probe Info  		N.A.  LDD0072  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C45(0.60)  LDD2142  [4]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C19(0.51); C45(0.83)  LDD2112  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C19(0.57)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C19(0.97)  LDD2152  [4]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C19(1.29)  LDD2103  [4]
 LDCM0545  Acetamide MDA-MB-231 C19(0.38)  LDD2138  [4]
 LDCM0520  AKOS000195272 MDA-MB-231 C19(0.37)  LDD2113  [4]
 LDCM0156  Aniline NCI-H1299 12.08  LDD0403  [3]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C19(1.66); C45(1.24)  LDD1702  [4]
 LDCM0625  F8 Ramos C19(0.62)  LDD2187  [20]
 LDCM0572  Fragment10 Ramos C19(0.76)  LDD2189  [20]
 LDCM0573  Fragment11 Ramos C19(0.06); 0.28  LDD2190  [20]
 LDCM0574  Fragment12 Ramos C19(1.07)  LDD2191  [20]
 LDCM0575  Fragment13 Ramos C19(1.24)  LDD2192  [20]
 LDCM0576  Fragment14 Ramos C19(0.65); 1.75  LDD2193  [20]
 LDCM0579  Fragment20 Ramos C19(0.99)  LDD2194  [20]
 LDCM0580  Fragment21 Ramos C19(1.06)  LDD2195  [20]
 LDCM0582  Fragment23 Ramos C19(0.86)  LDD2196  [20]
 LDCM0578  Fragment27 Ramos C19(1.15)  LDD2197  [20]
 LDCM0586  Fragment28 Ramos C19(0.78); 1.74  LDD2198  [20]
 LDCM0588  Fragment30 Ramos C19(1.63)  LDD2199  [20]
 LDCM0589  Fragment31 Ramos C19(1.03)  LDD2200  [20]
 LDCM0590  Fragment32 Ramos C19(0.83)  LDD2201  [20]
 LDCM0468  Fragment33 Ramos C19(1.14)  LDD2202  [20]
 LDCM0596  Fragment38 Ramos C19(1.31)  LDD2203  [20]
 LDCM0566  Fragment4 Ramos C19(0.80); 0.86  LDD2184  [20]
 LDCM0614  Fragment56 Ramos C19(1.87)  LDD2205  [20]
 LDCM0569  Fragment7 Ramos C19(0.56); 0.78  LDD2186  [20]
 LDCM0571  Fragment9 Ramos C19(1.01)  LDD2188  [20]
 LDCM0116  HHS-0101 DM93 Y15(0.80)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y15(1.00)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y15(0.82)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y15(0.87)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y15(0.75)  LDD0268  [6]
 LDCM0022  KB02 Ramos C19(0.49); 0.71  LDD2182  [20]
 LDCM0023  KB03 Jurkat C19(6.58); C43(4.66); C45(4.66)  LDD0209  [5]
 LDCM0024  KB05 Ramos C19(0.44); 0.69  LDD2185  [20]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C19(1.04)  LDD2102  [4]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C19(0.61)  LDD2089  [4]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C19(1.08)  LDD2090  [4]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C19(2.07)  LDD2092  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C19(1.06)  LDD2093  [4]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C45(1.84)  LDD2096  [4]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C19(0.47)  LDD2097  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C19(0.32)  LDD2098  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C19(0.94)  LDD2099  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C19(0.31)  LDD2100  [4]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C19(0.44)  LDD2101  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C19(0.32); C45(0.74)  LDD2104  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C19(0.87)  LDD2107  [4]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C45(0.75)  LDD2108  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C19(0.60)  LDD2109  [4]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C45(0.49)  LDD2110  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C19(0.77)  LDD2111  [4]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C45(0.36)  LDD2114  [4]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C19(0.33)  LDD2115  [4]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C19(0.73)  LDD2116  [4]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C19(0.70); C45(7.37)  LDD2118  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C19(1.31)  LDD2119  [4]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C19(0.58); C43(0.82)  LDD2120  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C19(0.61)  LDD2123  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C19(0.70)  LDD2125  [4]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C45(0.94)  LDD2126  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C19(0.73)  LDD2127  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C19(0.64); C45(1.24)  LDD2128  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C19(1.27)  LDD2129  [4]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C19(0.42)  LDD2133  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C19(0.45)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C19(1.28)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C19(0.94)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C19(0.80)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C19(1.05)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C19(0.51)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C19(0.50)  LDD2141  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C19(0.53); C45(0.88)  LDD2143  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C19(1.45)  LDD2144  [4]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C19(0.15)  LDD2145  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C19(0.81)  LDD2146  [4]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C19(1.23); C45(1.90)  LDD2147  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C19(0.34)  LDD2148  [4]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C19(1.33)  LDD2149  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C19(0.55)  LDD2150  [4]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C19(0.30)  LDD2151  [4]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C19(3.08)  LDD2153  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytochrome c oxidase assembly factor 7 (COA7) Hcp beta-lactamase family Q96BR5
Proteasome subunit alpha type-3 (PSMA3) Peptidase T1A family P25788
Exosome complex component RRP43 (EXOSC8) RNase PH family Q96B26
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
TNF receptor-associated factor 4 (TRAF4) TNF receptor-associated factor family Q9BUZ4
Methyltransferase-like protein 27 (METTL27) . Q8N6F8
NEDD4-like E3 ubiquitin-protein ligase WWP2 (WWP2) . O00308
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Beclin-1 (BECN1) Beclin family Q14457
Methylosome subunit pICln (CLNS1A) PICln (TC 1.A.47) family P54105
Transcription factor
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Zinc finger protein 143 (ZNF143) GLI C2H2-type zinc-finger protein family P52747
DNA-binding protein RFX6 (RFX6) RFX family Q8HWS3
Transcription factor Sp3 (SP3) Sp1 C2H2-type zinc-finger protein family Q02447
THAP domain-containing protein 3 (THAP3) . Q8WTV1
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytokine receptor-like factor 3 (CRLF3) Cytokine receptor-like factor 3 family Q8IUI8
Other
Click To Hide/Show 37 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
Protein BANP (BANP) BANP/SMAR1 family Q8N9N5
Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) CALCOCO family Q13137
Conserved oligomeric Golgi complex subunit 6 (COG6) COG6 family Q9Y2V7
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
GRB10-interacting GYF protein 1 (GIGYF1) GIGYF family O75420
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Protein INCA1 (INCA1) INCA family Q0VD86
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Oocyte-expressed protein homolog (OOEP) KHDC1 family A6NGQ2
Keratin-associated protein 19-1 (KRTAP19-1) KRTAP type 19 family Q8IUB9
Keratin-associated protein 19-6 (KRTAP19-6) KRTAP type 19 family Q3LI70
Keratin-associated protein 6-1 (KRTAP6-1) KRTAP type 6 family Q3LI64
Keratin-associated protein 6-2 (KRTAP6-2) KRTAP type 6 family Q3LI66
Methyl-CpG-binding domain protein 3-like 1 (MBD3L1) MBD3L family Q8WWY6
Metallothionein-2 (MT2A) Type 1 family P02795
Protein Mis18-beta (OIP5) Mis18 family O43482
Paraneoplastic antigen Ma1 (PNMA1) PNMA family Q8ND90
Prefoldin subunit 5 (PFDN5) Prefoldin subunit alpha family Q99471
Proline-rich protein 20D (PRR20D) PRR20 family P86480
Small nuclear ribonucleoprotein Sm D3 (SNRPD3) SnRNP core protein family P62318
U6 snRNA-associated Sm-like protein LSm2 (LSM2) SnRNP Sm proteins family Q9Y333
Calcium-responsive transactivator (SS18L1) SS18 family O75177
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
BAG family molecular chaperone regulator 4 (BAG4) . O95429
CD2 antigen cytoplasmic tail-binding protein 2 (CD2BP2) . O95400
Centrosomal protein of 55 kDa (CEP55) . Q53EZ4
Disabled homolog 1 (DAB1) . O75553
Four and a half LIM domains protein 3 (FHL3) . Q13643
Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) . P31943
Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3) . Q96JM7
Pleckstrin homology domain-containing family B member 2 (PLEKHB2) . Q96CS7
RNA-binding protein with multiple splicing (RBPMS) . Q93062
SERTA domain-containing protein 3 (SERTAD3) . Q9UJW9
Ubiquilin-2 (UBQLN2) . Q9UHD9
Uncharacterized protein C10orf55 (C10orf55) . Q5SWW7

References

1 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
16 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
17 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
18 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
19 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
20 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578