Details of the Target

General Information of Target

Target ID LDTP02325
Target Name Fibroblast growth factor 2 (FGF2)
Gene Name FGF2
Gene ID 2247
Synonyms
FGFB; Fibroblast growth factor 2; FGF-2; Basic fibroblast growth factor; bFGF; Heparin-binding growth factor 2; HBGF-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVGVGGGDVEDVTPRPGGCQISGRGARGCNGIPGAAAWEAALPRRRPRRHPSVNPRSRAA
GSPRTRGRRTEERPSGSRLGDRGRGRALPGGRLGGRGRGRAPERVGGRGRGRGTAAPRAA
PAARGSRPGPAGTMAAGSITTLPALPEDGGSGAFPPGHFKDPKRLYCKNGGFFLRIHPDG
RVDGVREKSDPHIKLQLQAEERGVVSIKGVCANRYLAMKEDGRLLASKCVTDECFFFERL
ESNNYNTYRSRKYTSWYVALKRTGQYKLGSKTGPGQKAILFLPMSAKS
Target Type
Successful
Target Bioclass
Transporter and channel
Family
Heparin-binding growth factors family
Subcellular location
Secreted
Function
Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Mediates phosphorylation of ERK1/2 and thereby promotes retinal lens fiber differentiation.
TTD ID
T31621
Uniprot ID
P09038
DrugMap ID
TTGKIED
Ensemble ID
ENST00000264498.9
HGNC ID
HGNC:3676
ChEMBL ID
CHEMBL3107

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C211(0.38)  LDD2117  [1]
Acrolein
 Probe Info  		N.A.  LDD0221  [2]
DBIA
 Probe Info  		C229(1.43)  LDD0078  [3]
IPM
 Probe Info  		N.A.  LDD0147  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C211(0.38)  LDD2117  [1]
 LDCM0214  AC1 HEK-293T C229(1.02)  LDD1507  [5]
 LDCM0215  AC10 HCT 116 C229(0.82)  LDD0532  [3]
 LDCM0226  AC11 HCT 116 C229(0.71)  LDD0543  [3]
 LDCM0230  AC113 HCT 116 C229(1.19)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C229(1.12)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C229(1.14)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C229(1.30)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C229(0.97)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C229(1.12)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C229(1.12)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C229(0.92)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C229(1.44)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C229(0.90)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C229(1.36)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C229(0.95)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C229(1.15)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C229(1.48)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C229(1.36)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C229(1.19)  LDD0562  [3]
 LDCM0259  AC14 HCT 116 C229(0.69)  LDD0576  [3]
 LDCM0270  AC15 HCT 116 C229(0.84)  LDD0587  [3]
 LDCM0276  AC17 HEK-293T C229(1.07)  LDD1515  [5]
 LDCM0277  AC18 HEK-293T C229(1.05)  LDD1516  [5]
 LDCM0278  AC19 HEK-293T C229(0.96)  LDD1517  [5]
 LDCM0279  AC2 HEK-293T C229(0.88)  LDD1518  [5]
 LDCM0280  AC20 HEK-293T C229(1.03)  LDD1519  [5]
 LDCM0281  AC21 HEK-293T C229(1.15)  LDD1520  [5]
 LDCM0282  AC22 HEK-293T C229(1.01)  LDD1521  [5]
 LDCM0283  AC23 HEK-293T C229(1.02)  LDD1522  [5]
 LDCM0284  AC24 HEK-293T C229(0.98)  LDD1523  [5]
 LDCM0285  AC25 HCT 116 C229(0.60)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C229(0.75)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C229(0.97)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C229(0.83)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C229(1.16)  LDD0606  [3]
 LDCM0290  AC3 HEK-293T C229(1.00)  LDD1529  [5]
 LDCM0291  AC30 HCT 116 C229(0.75)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C229(1.04)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C229(1.22)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C229(0.70)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C229(0.97)  LDD0612  [3]
 LDCM0296  AC35 HEK-293T C229(0.99)  LDD1535  [5]
 LDCM0297  AC36 HEK-293T C229(0.95)  LDD1536  [5]
 LDCM0298  AC37 HEK-293T C229(1.14)  LDD1537  [5]
 LDCM0299  AC38 HEK-293T C229(1.07)  LDD1538  [5]
 LDCM0300  AC39 HEK-293T C229(1.13)  LDD1539  [5]
 LDCM0301  AC4 HEK-293T C229(0.92)  LDD1540  [5]
 LDCM0302  AC40 HEK-293T C229(1.02)  LDD1541  [5]
 LDCM0303  AC41 HEK-293T C229(1.04)  LDD1542  [5]
 LDCM0304  AC42 HEK-293T C229(0.97)  LDD1543  [5]
 LDCM0305  AC43 HEK-293T C229(1.01)  LDD1544  [5]
 LDCM0306  AC44 HEK-293T C229(0.93)  LDD1545  [5]
 LDCM0307  AC45 HEK-293T C229(1.16)  LDD1546  [5]
 LDCM0308  AC46 HEK-293T C229(1.04)  LDD1547  [5]
 LDCM0309  AC47 HEK-293T C229(0.96)  LDD1548  [5]
 LDCM0310  AC48 HEK-293T C229(0.95)  LDD1549  [5]
 LDCM0311  AC49 HEK-293T C229(0.98)  LDD1550  [5]
 LDCM0312  AC5 HEK-293T C229(0.93)  LDD1551  [5]
 LDCM0313  AC50 HEK-293T C229(0.88)  LDD1552  [5]
 LDCM0314  AC51 HEK-293T C229(0.91)  LDD1553  [5]
 LDCM0315  AC52 HEK-293T C229(1.00)  LDD1554  [5]
 LDCM0316  AC53 HEK-293T C229(1.07)  LDD1555  [5]
 LDCM0317  AC54 HEK-293T C229(0.99)  LDD1556  [5]
 LDCM0318  AC55 HEK-293T C229(1.03)  LDD1557  [5]
 LDCM0319  AC56 HEK-293T C229(1.09)  LDD1558  [5]
 LDCM0320  AC57 HEK-293T C229(1.00)  LDD1559  [5]
 LDCM0321  AC58 HEK-293T C229(1.06)  LDD1560  [5]
 LDCM0322  AC59 HEK-293T C229(1.02)  LDD1561  [5]
 LDCM0323  AC6 HCT 116 C229(0.85)  LDD0640  [3]
 LDCM0324  AC60 HEK-293T C229(0.95)  LDD1563  [5]
 LDCM0325  AC61 HEK-293T C229(1.04)  LDD1564  [5]
 LDCM0326  AC62 HEK-293T C229(1.05)  LDD1565  [5]
 LDCM0327  AC63 HEK-293T C229(0.97)  LDD1566  [5]
 LDCM0328  AC64 HEK-293T C229(1.03)  LDD1567  [5]
 LDCM0334  AC7 HCT 116 C229(0.79)  LDD0651  [3]
 LDCM0345  AC8 HCT 116 C229(0.81)  LDD0662  [3]
 LDCM0248  AKOS034007472 HCT 116 C229(0.87)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C229(0.78)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C229(0.82)  LDD0592  [3]
 LDCM0020  ARS-1620 HCC44 C229(1.43)  LDD0078  [3]
 LDCM0367  CL1 HCT 116 C229(1.12)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C229(1.12)  LDD0685  [3]
 LDCM0369  CL100 HEK-293T C229(0.94)  LDD1573  [5]
 LDCM0370  CL101 HCT 116 C229(1.00)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C229(0.84)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C229(0.86)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C229(0.89)  LDD0690  [3]
 LDCM0374  CL105 HEK-293T C229(1.00)  LDD1578  [5]
 LDCM0375  CL106 HEK-293T C229(0.91)  LDD1579  [5]
 LDCM0376  CL107 HEK-293T C229(0.99)  LDD1580  [5]
 LDCM0377  CL108 HEK-293T C229(1.07)  LDD1581  [5]
 LDCM0378  CL109 HEK-293T C229(1.02)  LDD1582  [5]
 LDCM0379  CL11 HCT 116 C229(0.96)  LDD0696  [3]
 LDCM0380  CL110 HEK-293T C229(0.87)  LDD1584  [5]
 LDCM0381  CL111 HEK-293T C229(0.95)  LDD1585  [5]
 LDCM0382  CL112 HCT 116 C229(1.02)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C229(1.37)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C229(0.86)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C229(0.87)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C229(0.82)  LDD0703  [3]
 LDCM0387  CL117 HEK-293T C229(1.04)  LDD1591  [5]
 LDCM0388  CL118 HEK-293T C229(0.98)  LDD1592  [5]
 LDCM0389  CL119 HEK-293T C229(0.93)  LDD1593  [5]
 LDCM0390  CL12 HCT 116 C229(1.08)  LDD0707  [3]
 LDCM0391  CL120 HEK-293T C229(1.02)  LDD1595  [5]
 LDCM0392  CL121 HEK-293T C229(1.02)  LDD1596  [5]
 LDCM0393  CL122 HEK-293T C229(0.88)  LDD1597  [5]
 LDCM0394  CL123 HEK-293T C229(0.99)  LDD1598  [5]
 LDCM0395  CL124 HEK-293T C229(0.88)  LDD1599  [5]
 LDCM0396  CL125 HEK-293T C229(0.89)  LDD1600  [5]
 LDCM0397  CL126 HEK-293T C229(0.87)  LDD1601  [5]
 LDCM0398  CL127 HEK-293T C229(1.00)  LDD1602  [5]
 LDCM0399  CL128 HEK-293T C229(0.96)  LDD1603  [5]
 LDCM0400  CL13 HCT 116 C229(1.08)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C229(1.10)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C229(1.04)  LDD0719  [3]
 LDCM0403  CL16 HEK-293T C229(1.02)  LDD1607  [5]
 LDCM0404  CL17 HEK-293T C229(1.01)  LDD1608  [5]
 LDCM0405  CL18 HEK-293T C229(1.10)  LDD1609  [5]
 LDCM0406  CL19 HEK-293T C229(1.22)  LDD1610  [5]
 LDCM0407  CL2 HCT 116 C229(0.94)  LDD0724  [3]
 LDCM0408  CL20 HEK-293T C229(1.07)  LDD1612  [5]
 LDCM0409  CL21 HEK-293T C229(0.97)  LDD1613  [5]
 LDCM0410  CL22 HEK-293T C229(1.12)  LDD1614  [5]
 LDCM0411  CL23 HEK-293T C229(1.07)  LDD1615  [5]
 LDCM0412  CL24 HEK-293T C229(1.13)  LDD1616  [5]
 LDCM0413  CL25 HEK-293T C229(1.03)  LDD1617  [5]
 LDCM0414  CL26 HEK-293T C229(1.07)  LDD1618  [5]
 LDCM0415  CL27 HEK-293T C229(1.18)  LDD1619  [5]
 LDCM0416  CL28 HEK-293T C229(1.03)  LDD1620  [5]
 LDCM0417  CL29 HEK-293T C229(1.07)  LDD1621  [5]
 LDCM0418  CL3 HCT 116 C229(0.92)  LDD0735  [3]
 LDCM0419  CL30 HEK-293T C229(1.23)  LDD1623  [5]
 LDCM0420  CL31 HEK-293T C229(1.02)  LDD1624  [5]
 LDCM0421  CL32 HEK-293T C229(1.11)  LDD1625  [5]
 LDCM0422  CL33 HEK-293T C229(1.00)  LDD1626  [5]
 LDCM0423  CL34 HEK-293T C229(0.97)  LDD1627  [5]
 LDCM0424  CL35 HEK-293T C229(1.11)  LDD1628  [5]
 LDCM0425  CL36 HEK-293T C229(1.00)  LDD1629  [5]
 LDCM0426  CL37 HEK-293T C229(1.09)  LDD1630  [5]
 LDCM0428  CL39 HEK-293T C229(1.01)  LDD1632  [5]
 LDCM0429  CL4 HCT 116 C229(0.88)  LDD0746  [3]
 LDCM0430  CL40 HEK-293T C229(1.10)  LDD1634  [5]
 LDCM0431  CL41 HEK-293T C229(1.12)  LDD1635  [5]
 LDCM0432  CL42 HEK-293T C229(1.23)  LDD1636  [5]
 LDCM0433  CL43 HEK-293T C229(1.08)  LDD1637  [5]
 LDCM0434  CL44 HEK-293T C229(1.11)  LDD1638  [5]
 LDCM0435  CL45 HEK-293T C229(1.02)  LDD1639  [5]
 LDCM0436  CL46 HCT 116 C229(1.05)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C229(1.35)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C229(0.93)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C229(1.14)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C229(0.86)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C229(0.95)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C229(1.03)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C229(0.99)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C229(0.88)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C229(1.06)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C229(0.97)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C229(1.40)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C229(0.97)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C229(1.09)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C229(0.96)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C229(0.95)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C229(0.92)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C229(1.40)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C229(1.08)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C229(1.20)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C229(1.27)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C229(1.17)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C229(1.27)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C229(1.28)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C229(1.10)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C229(1.15)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C229(0.89)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C229(1.07)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C229(1.30)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C229(1.48)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C229(1.09)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C229(1.24)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C229(1.27)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C229(1.00)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C229(1.09)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C229(1.45)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C229(0.84)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C229(1.26)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C229(1.30)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C229(1.12)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C229(0.81)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C229(0.90)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C229(0.95)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C229(0.90)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C229(0.91)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C229(0.98)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C229(0.87)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C229(1.12)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C229(0.95)  LDD0802  [3]
 LDCM0486  CL91 HEK-293T C229(1.12)  LDD1689  [5]
 LDCM0487  CL92 HEK-293T C229(1.01)  LDD1690  [5]
 LDCM0488  CL93 HEK-293T C229(0.96)  LDD1691  [5]
 LDCM0489  CL94 HEK-293T C229(1.11)  LDD1692  [5]
 LDCM0490  CL95 HEK-293T C229(0.91)  LDD1693  [5]
 LDCM0491  CL96 HEK-293T C229(0.89)  LDD1694  [5]
 LDCM0492  CL97 HEK-293T C229(1.00)  LDD1695  [5]
 LDCM0493  CL98 HEK-293T C229(0.91)  LDD1696  [5]
 LDCM0494  CL99 HEK-293T C229(1.03)  LDD1697  [5]
 LDCM0495  E2913 HEK-293T C229(1.06)  LDD1698  [5]
 LDCM0468  Fragment33 HCT 116 C229(1.20)  LDD0785  [3]
 LDCM0427  Fragment51 HEK-293T C229(0.98)  LDD1631  [5]
 LDCM0107  IAA HeLa N.A.  LDD0221  [2]
 LDCM0022  KB02 HCT 116 C229(1.39)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C229(1.23)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C229(1.48)  LDD0082  [3]
 LDCM0109  NEM HeLa N.A.  LDD0224  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C211(0.81)  LDD2125  [1]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C211(0.46)  LDD2127  [1]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C211(1.51)  LDD2137  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Caspase-1 (CASP1) Peptidase C14A family P29466
Fibroblast growth factor receptor 1 (FGFR1) Tyr protein kinase family P11362
Fibroblast growth factor receptor 2 (FGFR2) Tyr protein kinase family P21802
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Fibroblast growth factor-binding protein 1 (FGFBP1) Fibroblast growth factor-binding protein family Q14512
Pentraxin-related protein PTX3 (PTX3) . P26022

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Heparin Small molecular drug DB01109
Pentosan Polysulfate Small molecular drug DB00686
Sucralfate . D06ULU
Phase 3
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Squalamine Small molecular drug D07PVB
Phase 2
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Bemarituzumab . D05ISO
Dvc1-0101 . D00IZD
Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Fpa144 . D06NND
Investigative
Click To Hide/Show 9 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
1,4-dideoxy-5-dehydro-o2-sulfo-glucuronic Acid Small molecular drug D0X4AL
1,4-dideoxy-o2-sulfo-glucuronic Acid Small molecular drug D0KL1I
14-dideoxy-5-dehydro-o2-sulfo-glucuronic Acid Small molecular drug DB03981
14-dideoxy-o2-sulfo-glucuronic Acid Small molecular drug DB03935
2-sulfhydryl-ethanol Small molecular drug D0Q5FV
Abt-510 Small molecular drug DB05434
N,O6-disulfo-glucosamine Small molecular drug D0B0SV
No6-disulfo-glucosamine Small molecular drug DB03959
Bibf100 . D0N1RE
Discontinued
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Rg-8803 . D09ZAV
Tgp-580 . D0B4XU

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402