Details of the Target

General Information of Target

Target ID LDTP02163
Target Name DNA polymerase beta (POLB)
Gene Name POLB
Gene ID 5423
Synonyms
DNA polymerase beta; EC 2.7.7.7; 5'-deoxyribose-phosphate lyase; 5'-dRP lyase; EC 4.2.99.-; AP lyase; EC 4.2.99.18
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAK
KLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIK
TLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGS
FRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQ
LPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRP
LGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
DNA polymerase type-X family
Subcellular location
Nucleus
Function
Repair polymerase that plays a key role in base-excision repair. During this process, the damaged base is excised by specific DNA glycosylases, the DNA backbone is nicked at the abasic site by an apurinic/apyrimidic (AP) endonuclease, and POLB removes 5'-deoxyribose-phosphate from the preincised AP site acting as a 5'-deoxyribose-phosphate lyase (5'-dRP lyase); through its DNA polymerase activity, it adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. It is also able to cleave sugar-phosphate bonds 3' to an intact AP site, acting as an AP lyase.
TTD ID
T06958
Uniprot ID
P06746
DrugMap ID
TTA0XPV
Ensemble ID
ENST00000265421.9
HGNC ID
HGNC:9174
ChEMBL ID
CHEMBL2392

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C267(0.52)  LDD0533  [1]
ATP probe
 Probe Info  		N.A.  LDD0199  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		C239(0.00); C178(0.00)  LDD0038  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		C239(0.00); C178(0.00)  LDD0037  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C267(0.17)  LDD1093  [1]
 LDCM0215  AC10 PaTu 8988t C267(0.33)  LDD1094  [1]
 LDCM0216  AC100 HCT 116 C267(0.52)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C267(0.61)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C267(0.57)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C267(0.27)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C267(0.34)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C267(0.28)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C267(0.27)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C267(0.35)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C267(0.52)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C267(0.45)  LDD0542  [1]
 LDCM0226  AC11 PaTu 8988t C267(0.22)  LDD1105  [1]
 LDCM0227  AC110 HCT 116 C267(0.49)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C267(0.41)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C267(0.34)  LDD0546  [1]
 LDCM0230  AC113 PaTu 8988t C267(0.82)  LDD1109  [1]
 LDCM0231  AC114 PaTu 8988t C267(1.19)  LDD1110  [1]
 LDCM0232  AC115 PaTu 8988t C267(0.85)  LDD1111  [1]
 LDCM0233  AC116 PaTu 8988t C267(0.73)  LDD1112  [1]
 LDCM0234  AC117 PaTu 8988t C267(1.00)  LDD1113  [1]
 LDCM0235  AC118 PaTu 8988t C267(1.06)  LDD1114  [1]
 LDCM0236  AC119 PaTu 8988t C267(0.26)  LDD1115  [1]
 LDCM0237  AC12 PaTu 8988t C267(0.33)  LDD1116  [1]
 LDCM0238  AC120 PaTu 8988t C267(0.61)  LDD1117  [1]
 LDCM0239  AC121 PaTu 8988t C267(0.16)  LDD1118  [1]
 LDCM0240  AC122 PaTu 8988t C267(1.13)  LDD1119  [1]
 LDCM0241  AC123 PaTu 8988t C267(0.67)  LDD1120  [1]
 LDCM0242  AC124 PaTu 8988t C267(0.16)  LDD1121  [1]
 LDCM0243  AC125 PaTu 8988t C267(0.86)  LDD1122  [1]
 LDCM0244  AC126 PaTu 8988t C267(0.99)  LDD1123  [1]
 LDCM0245  AC127 PaTu 8988t C267(0.24)  LDD1124  [1]
 LDCM0259  AC14 PaTu 8988t C267(0.23)  LDD1138  [1]
 LDCM0263  AC143 HCT 116 C267(0.44)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C267(0.17)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C267(0.68)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C267(0.41)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C267(0.15)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C267(0.13)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C267(0.15)  LDD0586  [1]
 LDCM0270  AC15 PaTu 8988t C267(0.41)  LDD1149  [1]
 LDCM0271  AC150 HCT 116 C267(0.57)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C267(0.69)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C267(0.13)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C267(0.14)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C267(0.23)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C267(0.20)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C267(0.66)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C267(0.70)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C267(1.03)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C267(0.31)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C267(0.92)  LDD0595  [1]
 LDCM0279  AC2 PaTu 8988t C267(0.47)  LDD1158  [1]
 LDCM0280  AC20 HCT 116 C267(1.51)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C267(0.68)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C267(0.76)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C267(0.81)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C267(1.27)  LDD0601  [1]
 LDCM0285  AC25 PaTu 8988t C267(0.87)  LDD1164  [1]
 LDCM0286  AC26 PaTu 8988t C267(1.11)  LDD1165  [1]
 LDCM0287  AC27 PaTu 8988t C267(0.88)  LDD1166  [1]
 LDCM0288  AC28 PaTu 8988t C267(0.54)  LDD1167  [1]
 LDCM0289  AC29 PaTu 8988t C267(1.14)  LDD1168  [1]
 LDCM0290  AC3 PaTu 8988t C267(0.16)  LDD1169  [1]
 LDCM0291  AC30 PaTu 8988t C267(0.98)  LDD1170  [1]
 LDCM0292  AC31 PaTu 8988t C267(1.05)  LDD1171  [1]
 LDCM0293  AC32 PaTu 8988t C267(0.85)  LDD1172  [1]
 LDCM0294  AC33 PaTu 8988t C267(0.28)  LDD1173  [1]
 LDCM0295  AC34 PaTu 8988t C267(1.03)  LDD1174  [1]
 LDCM0296  AC35 HCT 116 C267(2.04)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C267(2.83)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C267(1.30)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C267(1.41)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C267(0.64)  LDD0617  [1]
 LDCM0301  AC4 PaTu 8988t C267(0.38)  LDD1180  [1]
 LDCM0302  AC40 HCT 116 C267(0.67)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C267(1.45)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C267(0.86)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C267(1.09)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C267(0.95)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C267(0.71)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C267(1.47)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C267(0.82)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C267(1.89)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C267(0.50)  LDD0628  [1]
 LDCM0312  AC5 PaTu 8988t C267(0.18)  LDD1191  [1]
 LDCM0313  AC50 HCT 116 C267(0.45)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C267(2.45)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C267(0.70)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C267(0.55)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C267(0.50)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C267(0.47)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C267(0.61)  LDD0636  [1]
 LDCM0323  AC6 PaTu 8988t C267(0.78)  LDD1202  [1]
 LDCM0332  AC68 HCT 116 C267(0.36)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C267(0.43)  LDD0650  [1]
 LDCM0334  AC7 PaTu 8988t C267(1.46)  LDD1213  [1]
 LDCM0335  AC70 HCT 116 C267(0.26)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C267(0.72)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C267(0.30)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C267(0.36)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C267(0.41)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C267(0.45)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C267(0.28)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C267(0.24)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C267(0.64)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C267(0.51)  LDD0661  [1]
 LDCM0345  AC8 PaTu 8988t C267(1.08)  LDD1224  [1]
 LDCM0346  AC80 HCT 116 C267(0.30)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C267(0.44)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C267(0.41)  LDD0665  [1]
 LDCM0349  AC83 PaTu 8988t C267(2.06)  LDD1228  [1]
 LDCM0350  AC84 PaTu 8988t C267(1.20)  LDD1229  [1]
 LDCM0351  AC85 PaTu 8988t C267(2.48)  LDD1230  [1]
 LDCM0352  AC86 PaTu 8988t C267(1.64)  LDD1231  [1]
 LDCM0353  AC87 PaTu 8988t C267(3.41)  LDD1232  [1]
 LDCM0354  AC88 PaTu 8988t C267(2.68)  LDD1233  [1]
 LDCM0355  AC89 PaTu 8988t C267(1.84)  LDD1234  [1]
 LDCM0357  AC90 PaTu 8988t C267(3.81)  LDD1236  [1]
 LDCM0358  AC91 PaTu 8988t C267(4.14)  LDD1237  [1]
 LDCM0359  AC92 PaTu 8988t C267(1.57)  LDD1238  [1]
 LDCM0360  AC93 PaTu 8988t C267(3.47)  LDD1239  [1]
 LDCM0361  AC94 PaTu 8988t C267(3.12)  LDD1240  [1]
 LDCM0362  AC95 PaTu 8988t C267(2.26)  LDD1241  [1]
 LDCM0363  AC96 PaTu 8988t C267(4.46)  LDD1242  [1]
 LDCM0364  AC97 PaTu 8988t C267(3.14)  LDD1243  [1]
 LDCM0365  AC98 HCT 116 C267(0.17)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C267(0.83)  LDD0683  [1]
 LDCM0248  AKOS034007472 PaTu 8988t C267(0.25)  LDD1127  [1]
 LDCM0356  AKOS034007680 PaTu 8988t C267(0.53)  LDD1235  [1]
 LDCM0275  AKOS034007705 PaTu 8988t C267(0.77)  LDD1154  [1]
 LDCM0367  CL1 HCT 116 C267(1.32)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C267(0.33)  LDD0685  [1]
 LDCM0369  CL100 PaTu 8988t C267(0.41)  LDD1248  [1]
 LDCM0370  CL101 PaTu 8988t C267(0.90)  LDD1249  [1]
 LDCM0371  CL102 PaTu 8988t C267(0.78)  LDD1250  [1]
 LDCM0372  CL103 PaTu 8988t C267(0.28)  LDD1251  [1]
 LDCM0373  CL104 PaTu 8988t C267(0.33)  LDD1252  [1]
 LDCM0374  CL105 HCT 116 C267(0.55)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C267(0.50)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C267(0.38)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C267(0.31)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C267(0.65)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C267(0.33)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C267(0.68)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C267(0.73)  LDD0698  [1]
 LDCM0382  CL112 PaTu 8988t C267(0.76)  LDD1261  [1]
 LDCM0383  CL113 PaTu 8988t C267(0.85)  LDD1262  [1]
 LDCM0384  CL114 PaTu 8988t C267(0.75)  LDD1263  [1]
 LDCM0385  CL115 PaTu 8988t C267(0.72)  LDD1264  [1]
 LDCM0386  CL116 PaTu 8988t C267(1.36)  LDD1265  [1]
 LDCM0387  CL117 HCT 116 C267(0.72)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C267(0.71)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C267(0.77)  LDD0706  [1]
 LDCM0390  CL12 HCT 116 C267(0.29)  LDD0707  [1]
 LDCM0391  CL120 HCT 116 C267(1.04)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C267(0.75)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C267(0.83)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C267(0.46)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C267(0.41)  LDD0712  [1]
 LDCM0400  CL13 HCT 116 C267(0.52)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C267(0.73)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C267(0.70)  LDD0719  [1]
 LDCM0403  CL16 PaTu 8988t C267(0.26)  LDD1282  [1]
 LDCM0404  CL17 PaTu 8988t C267(0.19)  LDD1283  [1]
 LDCM0405  CL18 PaTu 8988t C267(0.22)  LDD1284  [1]
 LDCM0406  CL19 PaTu 8988t C267(0.22)  LDD1285  [1]
 LDCM0407  CL2 HCT 116 C267(1.17)  LDD0724  [1]
 LDCM0408  CL20 PaTu 8988t C267(0.22)  LDD1287  [1]
 LDCM0409  CL21 PaTu 8988t C267(0.25)  LDD1288  [1]
 LDCM0410  CL22 PaTu 8988t C267(0.23)  LDD1289  [1]
 LDCM0411  CL23 PaTu 8988t C267(0.20)  LDD1290  [1]
 LDCM0412  CL24 PaTu 8988t C267(0.20)  LDD1291  [1]
 LDCM0413  CL25 PaTu 8988t C267(0.55)  LDD1292  [1]
 LDCM0414  CL26 PaTu 8988t C267(0.22)  LDD1293  [1]
 LDCM0415  CL27 PaTu 8988t C267(0.25)  LDD1294  [1]
 LDCM0416  CL28 PaTu 8988t C267(0.22)  LDD1295  [1]
 LDCM0417  CL29 PaTu 8988t C267(0.25)  LDD1296  [1]
 LDCM0418  CL3 HCT 116 C267(1.10)  LDD0735  [1]
 LDCM0419  CL30 PaTu 8988t C267(0.47)  LDD1298  [1]
 LDCM0420  CL31 HCT 116 C267(0.80)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C267(3.78)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C267(1.23)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C267(0.24)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C267(0.31)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C267(0.23)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C267(0.38)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C267(0.24)  LDD0745  [1]
 LDCM0429  CL4 HCT 116 C267(0.89)  LDD0746  [1]
 LDCM0430  CL40 HCT 116 C267(0.28)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C267(0.39)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C267(0.26)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C267(0.40)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C267(0.48)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C267(0.27)  LDD0752  [1]
 LDCM0436  CL46 PaTu 8988t C267(0.98)  LDD1315  [1]
 LDCM0437  CL47 PaTu 8988t C267(0.87)  LDD1316  [1]
 LDCM0438  CL48 PaTu 8988t C267(0.92)  LDD1317  [1]
 LDCM0439  CL49 PaTu 8988t C267(0.72)  LDD1318  [1]
 LDCM0440  CL5 HCT 116 C267(0.73)  LDD0757  [1]
 LDCM0441  CL50 PaTu 8988t C267(0.46)  LDD1320  [1]
 LDCM0442  CL51 PaTu 8988t C267(0.82)  LDD1321  [1]
 LDCM0443  CL52 PaTu 8988t C267(0.81)  LDD1322  [1]
 LDCM0444  CL53 PaTu 8988t C267(0.35)  LDD1323  [1]
 LDCM0445  CL54 PaTu 8988t C267(0.90)  LDD1324  [1]
 LDCM0446  CL55 PaTu 8988t C267(1.18)  LDD1325  [1]
 LDCM0447  CL56 PaTu 8988t C267(0.20)  LDD1326  [1]
 LDCM0448  CL57 PaTu 8988t C267(0.17)  LDD1327  [1]
 LDCM0449  CL58 PaTu 8988t C267(0.26)  LDD1328  [1]
 LDCM0450  CL59 PaTu 8988t C267(0.20)  LDD1329  [1]
 LDCM0451  CL6 HCT 116 C267(0.93)  LDD0768  [1]
 LDCM0452  CL60 PaTu 8988t C267(0.15)  LDD1331  [1]
 LDCM0462  CL7 HCT 116 C267(0.33)  LDD0779  [1]
 LDCM0469  CL76 PaTu 8988t C267(1.11)  LDD1348  [1]
 LDCM0470  CL77 PaTu 8988t C267(0.79)  LDD1349  [1]
 LDCM0471  CL78 PaTu 8988t C267(0.44)  LDD1350  [1]
 LDCM0472  CL79 PaTu 8988t C267(0.66)  LDD1351  [1]
 LDCM0473  CL8 HCT 116 C267(0.29)  LDD0790  [1]
 LDCM0474  CL80 PaTu 8988t C267(1.28)  LDD1353  [1]
 LDCM0475  CL81 PaTu 8988t C267(0.24)  LDD1354  [1]
 LDCM0476  CL82 PaTu 8988t C267(0.85)  LDD1355  [1]
 LDCM0477  CL83 PaTu 8988t C267(0.42)  LDD1356  [1]
 LDCM0478  CL84 PaTu 8988t C267(0.13)  LDD1357  [1]
 LDCM0479  CL85 PaTu 8988t C267(0.67)  LDD1358  [1]
 LDCM0480  CL86 PaTu 8988t C267(0.77)  LDD1359  [1]
 LDCM0481  CL87 PaTu 8988t C267(0.16)  LDD1360  [1]
 LDCM0482  CL88 PaTu 8988t C267(0.26)  LDD1361  [1]
 LDCM0483  CL89 PaTu 8988t C267(0.16)  LDD1362  [1]
 LDCM0484  CL9 HCT 116 C267(0.42)  LDD0801  [1]
 LDCM0485  CL90 PaTu 8988t C267(0.14)  LDD1364  [1]
 LDCM0486  CL91 PaTu 8988t C267(0.59)  LDD1365  [1]
 LDCM0487  CL92 PaTu 8988t C267(0.50)  LDD1366  [1]
 LDCM0488  CL93 PaTu 8988t C267(0.47)  LDD1367  [1]
 LDCM0489  CL94 PaTu 8988t C267(0.54)  LDD1368  [1]
 LDCM0490  CL95 PaTu 8988t C267(0.41)  LDD1369  [1]
 LDCM0491  CL96 PaTu 8988t C267(0.45)  LDD1370  [1]
 LDCM0492  CL97 PaTu 8988t C267(0.54)  LDD1371  [1]
 LDCM0493  CL98 PaTu 8988t C267(0.43)  LDD1372  [1]
 LDCM0494  CL99 PaTu 8988t C267(0.47)  LDD1373  [1]
 LDCM0427  Fragment51 HCT 116 C267(0.31)  LDD0744  [1]
 LDCM0022  KB02 A2780 C239(2.51); C178(2.26)  LDD2254  [4]
 LDCM0023  KB03 A2780 C239(4.12); C178(2.28)  LDD2671  [4]
 LDCM0024  KB05 IGR37 C239(4.80); C178(4.45)  LDD3314  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tripeptidyl-peptidase 2 (TPP2) Peptidase S8 family P29144
TATA box-binding protein-associated factor RNA polymerase I subunit D (TAF1D) . Q9H5J8
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Wolframin (WFS1) . O76024
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA repair protein XRCC1 (XRCC1) . P18887

The Drug(s) Related To This Target

Approved
Click To Hide/Show 7 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cytarabine Small molecular drug DB00987
Iron Small molecular drug DB01592
Ferrous Ascorbate . DB14490
Ferrous Fumarate . DB14491
Ferrous Gluconate . DB14488
Ferrous Glycine Sulfate . DB14501
Ferrous Succinate . DB14489
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ff-10502 Small molecular drug DL30JC
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Datp Small molecular drug DB03222
(1s)-1234-tetrahydro-benzo[C]Phenanthrene-234-triol . DB07479

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840