Details of the Target

General Information of Target

Target ID LDTP02019
Target Name Superoxide dismutase [Mn], mitochondrial (SOD2)
Gene Name SOD2
Gene ID 6648
Synonyms
Superoxide dismutase [Mn], mitochondrial; EC 1.15.1.1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLSRAVCGTSRQLAPVLGYLGSRQKHSLPDLPYDYGALEPHINAQIMQLHHSKHHAAYVN
NLNVTEEKYQEALAKGDVTAQIALQPALKFNGGGHINHSIFWTNLSPNGGGEPKGELLEA
IKRDFGSFDKFKEKLTAASVGVQGSGWGWLGFNKERGHLQIAACPNQDPLQGTTGLIPLL
GIDVWEHAYYLQYKNVRPDYLKAIWNVINWENVTERYMACKK
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Iron/manganese superoxide dismutase family
Subcellular location
Mitochondrion matrix
Function Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
TTD ID
T89147
Uniprot ID
P04179
DrugMap ID
TT9O4C5
Ensemble ID
ENST00000337404.8
HGNC ID
HGNC:11180
ChEMBL ID
CHEMBL4105776

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		100.00  LDD0444  [1]
STPyne
 Probe Info  		K122(1.12); K130(9.82); K132(1.06)  LDD0277  [2]
m-APA
 Probe Info  		9.76  LDD0403  [3]
DBIA
 Probe Info  		C7(2.03)  LDD3318  [4]
AHL-Pu-1
 Probe Info  		C220(3.88)  LDD0171  [5]
IPM
 Probe Info  		C7(1.06)  LDD1701  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [7]
NHS
 Probe Info  		N.A.  LDD0010  [8]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [9]
1c-yne
 Probe Info  		N.A.  LDD0228  [10]
NAIA_5
 Probe Info  		N.A.  LDD2223  [11]
TER-AC
 Probe Info  		N.A.  LDD0426  [12]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		13.95  LDD0475  [13]
FFF probe4
 Probe Info  		15.02  LDD0466  [13]
DA-2
 Probe Info  		N.A.  LDD0070  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C220(3.88)  LDD0171  [5]
 LDCM0215  AC10 HEK-293T C164(1.00)  LDD1508  [15]
 LDCM0226  AC11 HEK-293T C164(0.83)  LDD1509  [15]
 LDCM0237  AC12 HEK-293T C164(0.78)  LDD1510  [15]
 LDCM0259  AC14 HEK-293T C164(1.11)  LDD1512  [15]
 LDCM0270  AC15 HEK-293T C164(1.04)  LDD1513  [15]
 LDCM0277  AC18 HEK-293T C164(0.84)  LDD1516  [15]
 LDCM0278  AC19 HEK-293T C164(0.95)  LDD1517  [15]
 LDCM0279  AC2 HEK-293T C164(1.07)  LDD1518  [15]
 LDCM0280  AC20 HEK-293T C164(1.04)  LDD1519  [15]
 LDCM0281  AC21 HEK-293T C164(1.31)  LDD1520  [15]
 LDCM0282  AC22 HEK-293T C164(1.40)  LDD1521  [15]
 LDCM0283  AC23 HEK-293T C164(1.07)  LDD1522  [15]
 LDCM0284  AC24 HEK-293T C164(1.21)  LDD1523  [15]
 LDCM0286  AC26 HEK-293T C164(1.11)  LDD1525  [15]
 LDCM0287  AC27 HEK-293T C164(1.00)  LDD1526  [15]
 LDCM0288  AC28 HEK-293T C164(1.13)  LDD1527  [15]
 LDCM0289  AC29 HEK-293T C164(1.11)  LDD1528  [15]
 LDCM0290  AC3 HEK-293T C164(1.03)  LDD1529  [15]
 LDCM0291  AC30 HEK-293T C164(1.28)  LDD1530  [15]
 LDCM0292  AC31 HEK-293T C164(1.12)  LDD1531  [15]
 LDCM0293  AC32 HEK-293T C164(0.97)  LDD1532  [15]
 LDCM0295  AC34 HEK-293T C164(1.05)  LDD1534  [15]
 LDCM0296  AC35 HEK-293T C164(0.88)  LDD1535  [15]
 LDCM0297  AC36 HEK-293T C164(0.97)  LDD1536  [15]
 LDCM0298  AC37 HEK-293T C164(0.98)  LDD1537  [15]
 LDCM0299  AC38 HEK-293T C164(1.29)  LDD1538  [15]
 LDCM0300  AC39 HEK-293T C164(0.81)  LDD1539  [15]
 LDCM0301  AC4 HEK-293T C164(1.00)  LDD1540  [15]
 LDCM0302  AC40 HEK-293T C164(0.97)  LDD1541  [15]
 LDCM0304  AC42 HEK-293T C164(1.23)  LDD1543  [15]
 LDCM0305  AC43 HEK-293T C164(1.03)  LDD1544  [15]
 LDCM0306  AC44 HEK-293T C164(0.84)  LDD1545  [15]
 LDCM0307  AC45 HEK-293T C164(0.79)  LDD1546  [15]
 LDCM0308  AC46 HEK-293T C164(1.49)  LDD1547  [15]
 LDCM0309  AC47 HEK-293T C164(1.19)  LDD1548  [15]
 LDCM0310  AC48 HEK-293T C164(1.01)  LDD1549  [15]
 LDCM0312  AC5 HEK-293T C164(0.97)  LDD1551  [15]
 LDCM0313  AC50 HEK-293T C164(0.95)  LDD1552  [15]
 LDCM0314  AC51 HEK-293T C164(1.03)  LDD1553  [15]
 LDCM0315  AC52 HEK-293T C164(0.88)  LDD1554  [15]
 LDCM0316  AC53 HEK-293T C164(1.04)  LDD1555  [15]
 LDCM0317  AC54 HEK-293T C164(1.14)  LDD1556  [15]
 LDCM0318  AC55 HEK-293T C164(1.28)  LDD1557  [15]
 LDCM0319  AC56 HEK-293T C164(0.96)  LDD1558  [15]
 LDCM0321  AC58 HEK-293T C164(1.19)  LDD1560  [15]
 LDCM0322  AC59 HEK-293T C164(1.15)  LDD1561  [15]
 LDCM0323  AC6 HEK-293T C164(1.16)  LDD1562  [15]
 LDCM0324  AC60 HEK-293T C164(1.03)  LDD1563  [15]
 LDCM0325  AC61 HEK-293T C164(1.05)  LDD1564  [15]
 LDCM0326  AC62 HEK-293T C164(1.33)  LDD1565  [15]
 LDCM0327  AC63 HEK-293T C164(0.95)  LDD1566  [15]
 LDCM0328  AC64 HEK-293T C164(1.13)  LDD1567  [15]
 LDCM0334  AC7 HEK-293T C164(1.25)  LDD1568  [15]
 LDCM0345  AC8 HEK-293T C164(1.16)  LDD1569  [15]
 LDCM0248  AKOS034007472 HEK-293T C164(1.02)  LDD1511  [15]
 LDCM0275  AKOS034007705 HEK-293T C164(1.13)  LDD1514  [15]
 LDCM0156  Aniline NCI-H1299 9.76  LDD0403  [3]
 LDCM0367  CL1 HEK-293T C164(1.05)  LDD1571  [15]
 LDCM0368  CL10 HEK-293T C164(0.81)  LDD1572  [15]
 LDCM0369  CL100 HEK-293T C164(1.00)  LDD1573  [15]
 LDCM0370  CL101 HEK-293T C164(1.07)  LDD1574  [15]
 LDCM0371  CL102 HEK-293T C164(1.11)  LDD1575  [15]
 LDCM0373  CL104 HEK-293T C164(0.92)  LDD1577  [15]
 LDCM0374  CL105 HEK-293T C164(1.46)  LDD1578  [15]
 LDCM0375  CL106 HEK-293T C164(1.12)  LDD1579  [15]
 LDCM0377  CL108 HEK-293T C164(1.15)  LDD1581  [15]
 LDCM0378  CL109 HEK-293T C164(1.14)  LDD1582  [15]
 LDCM0379  CL11 HEK-293T C164(0.78)  LDD1583  [15]
 LDCM0380  CL110 HEK-293T C164(0.86)  LDD1584  [15]
 LDCM0382  CL112 HEK-293T C164(0.84)  LDD1586  [15]
 LDCM0383  CL113 HEK-293T C164(0.99)  LDD1587  [15]
 LDCM0384  CL114 HEK-293T C164(1.10)  LDD1588  [15]
 LDCM0386  CL116 HEK-293T C164(0.95)  LDD1590  [15]
 LDCM0387  CL117 HEK-293T C164(0.99)  LDD1591  [15]
 LDCM0388  CL118 HEK-293T C164(1.08)  LDD1592  [15]
 LDCM0390  CL12 HEK-293T C164(0.70)  LDD1594  [15]
 LDCM0391  CL120 HEK-293T C164(1.19)  LDD1595  [15]
 LDCM0392  CL121 HEK-293T C164(1.03)  LDD1596  [15]
 LDCM0393  CL122 HEK-293T C164(1.14)  LDD1597  [15]
 LDCM0395  CL124 HEK-293T C164(0.99)  LDD1599  [15]
 LDCM0396  CL125 HEK-293T C164(1.29)  LDD1600  [15]
 LDCM0397  CL126 HEK-293T C164(1.36)  LDD1601  [15]
 LDCM0399  CL128 HEK-293T C164(1.26)  LDD1603  [15]
 LDCM0400  CL13 HEK-293T C164(0.74)  LDD1604  [15]
 LDCM0401  CL14 HEK-293T C164(1.10)  LDD1605  [15]
 LDCM0403  CL16 HEK-293T C164(0.88)  LDD1607  [15]
 LDCM0405  CL18 HEK-293T C164(0.70)  LDD1609  [15]
 LDCM0406  CL19 HEK-293T C164(0.77)  LDD1610  [15]
 LDCM0407  CL2 HEK-293T C164(0.95)  LDD1611  [15]
 LDCM0408  CL20 HEK-293T C164(0.73)  LDD1612  [15]
 LDCM0409  CL21 HEK-293T C164(0.64)  LDD1613  [15]
 LDCM0410  CL22 HEK-293T C164(0.80)  LDD1614  [15]
 LDCM0411  CL23 HEK-293T C164(0.83)  LDD1615  [15]
 LDCM0412  CL24 HEK-293T C164(0.77)  LDD1616  [15]
 LDCM0413  CL25 HEK-293T C164(1.14)  LDD1617  [15]
 LDCM0414  CL26 HEK-293T C164(0.90)  LDD1618  [15]
 LDCM0416  CL28 HEK-293T C164(0.81)  LDD1620  [15]
 LDCM0419  CL30 HEK-293T C164(1.00)  LDD1623  [15]
 LDCM0420  CL31 HEK-293T C164(0.62)  LDD1624  [15]
 LDCM0421  CL32 HEK-293T C164(0.76)  LDD1625  [15]
 LDCM0422  CL33 HEK-293T C164(0.68)  LDD1626  [15]
 LDCM0423  CL34 HEK-293T C164(0.93)  LDD1627  [15]
 LDCM0424  CL35 HEK-293T C164(0.78)  LDD1628  [15]
 LDCM0425  CL36 HEK-293T C164(0.77)  LDD1629  [15]
 LDCM0426  CL37 HEK-293T C164(1.13)  LDD1630  [15]
 LDCM0429  CL4 HEK-293T C164(0.70)  LDD1633  [15]
 LDCM0430  CL40 HEK-293T C164(0.84)  LDD1634  [15]
 LDCM0432  CL42 HEK-293T C164(0.87)  LDD1636  [15]
 LDCM0433  CL43 HEK-293T C164(1.07)  LDD1637  [15]
 LDCM0434  CL44 HEK-293T C164(0.89)  LDD1638  [15]
 LDCM0435  CL45 HEK-293T C164(0.67)  LDD1639  [15]
 LDCM0436  CL46 HEK-293T C164(1.03)  LDD1640  [15]
 LDCM0437  CL47 HEK-293T C164(0.75)  LDD1641  [15]
 LDCM0438  CL48 HEK-293T C164(0.77)  LDD1642  [15]
 LDCM0439  CL49 HEK-293T C164(1.29)  LDD1643  [15]
 LDCM0441  CL50 HEK-293T C164(0.96)  LDD1645  [15]
 LDCM0443  CL52 HEK-293T C164(0.97)  LDD1646  [15]
 LDCM0445  CL54 HEK-293T C164(0.80)  LDD1648  [15]
 LDCM0446  CL55 HEK-293T C164(0.95)  LDD1649  [15]
 LDCM0447  CL56 HEK-293T C164(0.82)  LDD1650  [15]
 LDCM0448  CL57 HEK-293T C164(0.88)  LDD1651  [15]
 LDCM0449  CL58 HEK-293T C164(1.02)  LDD1652  [15]
 LDCM0450  CL59 HEK-293T C164(0.65)  LDD1653  [15]
 LDCM0451  CL6 HEK-293T C164(0.58)  LDD1654  [15]
 LDCM0452  CL60 HEK-293T C164(0.80)  LDD1655  [15]
 LDCM0453  CL61 HEK-293T C164(1.41)  LDD1656  [15]
 LDCM0454  CL62 HEK-293T C164(1.14)  LDD1657  [15]
 LDCM0456  CL64 HEK-293T C164(0.84)  LDD1659  [15]
 LDCM0458  CL66 HEK-293T C164(0.93)  LDD1661  [15]
 LDCM0459  CL67 HEK-293T C164(0.82)  LDD1662  [15]
 LDCM0460  CL68 HEK-293T C164(0.66)  LDD1663  [15]
 LDCM0461  CL69 HEK-293T C164(0.82)  LDD1664  [15]
 LDCM0462  CL7 HEK-293T C164(0.73)  LDD1665  [15]
 LDCM0463  CL70 HEK-293T C164(0.91)  LDD1666  [15]
 LDCM0464  CL71 HEK-293T C164(0.96)  LDD1667  [15]
 LDCM0465  CL72 HEK-293T C164(0.61)  LDD1668  [15]
 LDCM0466  CL73 HEK-293T C164(1.39)  LDD1669  [15]
 LDCM0467  CL74 HEK-293T C164(1.13)  LDD1670  [15]
 LDCM0469  CL76 HEK-293T C164(0.90)  LDD1672  [15]
 LDCM0471  CL78 HEK-293T C164(0.93)  LDD1674  [15]
 LDCM0472  CL79 HEK-293T C164(1.02)  LDD1675  [15]
 LDCM0473  CL8 HEK-293T C164(0.75)  LDD1676  [15]
 LDCM0474  CL80 HEK-293T C164(1.04)  LDD1677  [15]
 LDCM0475  CL81 HEK-293T C164(0.80)  LDD1678  [15]
 LDCM0476  CL82 HEK-293T C164(1.23)  LDD1679  [15]
 LDCM0477  CL83 HEK-293T C164(1.07)  LDD1680  [15]
 LDCM0478  CL84 HEK-293T C164(0.85)  LDD1681  [15]
 LDCM0479  CL85 HEK-293T C164(1.24)  LDD1682  [15]
 LDCM0480  CL86 HEK-293T C164(1.05)  LDD1683  [15]
 LDCM0482  CL88 HEK-293T C164(1.09)  LDD1685  [15]
 LDCM0484  CL9 HEK-293T C164(0.66)  LDD1687  [15]
 LDCM0485  CL90 HEK-293T C164(0.72)  LDD1688  [15]
 LDCM0486  CL91 HEK-293T C164(1.01)  LDD1689  [15]
 LDCM0487  CL92 HEK-293T C164(0.60)  LDD1690  [15]
 LDCM0488  CL93 HEK-293T C164(0.53)  LDD1691  [15]
 LDCM0489  CL94 HEK-293T C164(1.10)  LDD1692  [15]
 LDCM0490  CL95 HEK-293T C164(0.70)  LDD1693  [15]
 LDCM0491  CL96 HEK-293T C164(0.82)  LDD1694  [15]
 LDCM0492  CL97 HEK-293T C164(1.03)  LDD1695  [15]
 LDCM0493  CL98 HEK-293T C164(1.22)  LDD1696  [15]
 LDCM0427  Fragment51 HEK-293T C164(1.08)  LDD1631  [15]
 LDCM0022  KB02 HEK-293T C164(1.18)  LDD1492  [15]
 LDCM0023  KB03 HEK-293T C164(1.03)  LDD1497  [15]
 LDCM0024  KB05 MELHO C7(2.03)  LDD3318  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Superoxide dismutase [Mn], mitochondrial (SOD2) Iron/manganese superoxide dismutase family P04179
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Benzoyl Peroxide . DB09096
Thimerosal . DB11590
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Imisopasem Manganese Small molecular drug D00OYQ
Investigative
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
3-fluoro-l-tyrosine . DB04436
Benzylsulfonic Acid . DB03297
Polaprezinc . DB09221

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
13 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
14 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402