Details of the Target

General Information of Target

Target ID LDTP01655
Target Name Ribonuclease P protein subunit p29 (POP4)
Gene Name POP4
Gene ID 10775
Synonyms
RPP29; Ribonuclease P protein subunit p29; hPOP4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKSVIYHALSQKEANDSDVQPSGAQRAEAFVRAFLKRSTPRMSPQAREDQLQRKAVVLEY
FTRHKRKEKKKKAKGLSARQRRELRLFDIKPEQQRYSLFLPLHELWKQYIRDLCSGLKPD
TQPQMIQAKLLKADLHGAIISVTKSKCPSYVGITGILLQETKHIFKIITKEDRLKVIPKL
NCVFTVETDGFISYIYGSKFQLRSSERSAKKFKAKGTIDL
Target Bioclass
Enzyme
Family
Eukaryotic/archaeal RNase P protein component 1 family
Subcellular location
Nucleus, nucleolus
Function Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Uniprot ID
O95707
Ensemble ID
ENST00000585603.6
HGNC ID
HGNC:30081

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K54(10.00)  LDD0277  [1]
m-APA
 Probe Info  		11.71  LDD0403  [2]
DBIA
 Probe Info  		C147(0.95)  LDD0078  [3]
ATP probe
 Probe Info  		N.A.  LDD0199  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
IA-alkyne
 Probe Info  		C147(0.00); C114(0.00)  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		C147(0.00); C114(0.00)  LDD0037  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [6]
TFBX
 Probe Info  		N.A.  LDD0027  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C147(1.09)  LDD0531  [3]
 LDCM0215  AC10 HEK-293T C147(1.04)  LDD0813  [3]
 LDCM0216  AC100 HEK-293T C147(1.07)  LDD0814  [3]
 LDCM0217  AC101 HEK-293T C147(1.12)  LDD0815  [3]
 LDCM0218  AC102 HEK-293T C147(1.24)  LDD0816  [3]
 LDCM0219  AC103 HEK-293T C147(1.07)  LDD0817  [3]
 LDCM0220  AC104 HEK-293T C147(1.10)  LDD0818  [3]
 LDCM0221  AC105 HEK-293T C147(0.93)  LDD0819  [3]
 LDCM0222  AC106 HEK-293T C147(0.90)  LDD0820  [3]
 LDCM0223  AC107 HEK-293T C147(0.96)  LDD0821  [3]
 LDCM0224  AC108 HEK-293T C147(1.01)  LDD0822  [3]
 LDCM0225  AC109 HEK-293T C147(0.97)  LDD0823  [3]
 LDCM0226  AC11 HEK-293T C147(1.00)  LDD0824  [3]
 LDCM0227  AC110 HEK-293T C147(1.23)  LDD0825  [3]
 LDCM0228  AC111 HEK-293T C147(1.27)  LDD0826  [3]
 LDCM0229  AC112 HEK-293T C147(1.29)  LDD0827  [3]
 LDCM0237  AC12 HEK-293T C147(0.87)  LDD0835  [3]
 LDCM0259  AC14 HEK-293T C147(1.08)  LDD0857  [3]
 LDCM0263  AC143 PaTu 8988t C147(1.06)  LDD1142  [3]
 LDCM0264  AC144 PaTu 8988t C147(0.97)  LDD1143  [3]
 LDCM0265  AC145 PaTu 8988t C147(1.41)  LDD1144  [3]
 LDCM0266  AC146 PaTu 8988t C147(1.00)  LDD1145  [3]
 LDCM0267  AC147 PaTu 8988t C147(1.28)  LDD1146  [3]
 LDCM0268  AC148 PaTu 8988t C147(1.09)  LDD1147  [3]
 LDCM0269  AC149 PaTu 8988t C147(1.19)  LDD1148  [3]
 LDCM0270  AC15 HEK-293T C147(0.97)  LDD0868  [3]
 LDCM0271  AC150 PaTu 8988t C147(1.10)  LDD1150  [3]
 LDCM0272  AC151 PaTu 8988t C147(1.03)  LDD1151  [3]
 LDCM0273  AC152 PaTu 8988t C147(1.14)  LDD1152  [3]
 LDCM0274  AC153 PaTu 8988t C147(1.18)  LDD1153  [3]
 LDCM0621  AC154 PaTu 8988t C147(0.89)  LDD2166  [3]
 LDCM0622  AC155 PaTu 8988t C147(1.09)  LDD2167  [3]
 LDCM0623  AC156 PaTu 8988t C147(1.12)  LDD2168  [3]
 LDCM0624  AC157 PaTu 8988t C147(0.84)  LDD2169  [3]
 LDCM0276  AC17 HEK-293T C147(0.95)  LDD0874  [3]
 LDCM0277  AC18 HEK-293T C147(0.91)  LDD0875  [3]
 LDCM0278  AC19 HEK-293T C147(1.06)  LDD0876  [3]
 LDCM0279  AC2 HCT 116 C147(1.14)  LDD0596  [3]
 LDCM0280  AC20 HEK-293T C147(1.01)  LDD0878  [3]
 LDCM0281  AC21 HEK-293T C147(1.10)  LDD0879  [3]
 LDCM0282  AC22 HEK-293T C147(1.05)  LDD0880  [3]
 LDCM0283  AC23 HEK-293T C147(1.04)  LDD0881  [3]
 LDCM0284  AC24 HEK-293T C147(0.85)  LDD0882  [3]
 LDCM0285  AC25 HEK-293T C147(0.98)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C147(1.03)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C147(1.07)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C147(0.98)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C147(0.88)  LDD0887  [3]
 LDCM0290  AC3 HCT 116 C147(1.12)  LDD0607  [3]
 LDCM0291  AC30 HEK-293T C147(0.93)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C147(0.88)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C147(1.06)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C147(0.99)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C147(0.94)  LDD0893  [3]
 LDCM0296  AC35 HCT 116 C147(0.82)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C147(1.10)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C147(1.18)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C147(1.31)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C147(1.25)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C147(1.10)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C147(1.07)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C147(1.28)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C147(1.21)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C147(1.29)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C147(1.23)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C147(1.01)  LDD0624  [3]
 LDCM0308  AC46 HEK-293T C147(1.55)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C147(1.40)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C147(1.25)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C147(1.15)  LDD0909  [3]
 LDCM0312  AC5 HCT 116 C147(1.17)  LDD0629  [3]
 LDCM0313  AC50 HEK-293T C147(1.22)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C147(1.20)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C147(1.26)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C147(1.24)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C147(1.56)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C147(1.23)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C147(1.36)  LDD0917  [3]
 LDCM0320  AC57 HEK-293T C147(0.95)  LDD0918  [3]
 LDCM0321  AC58 HEK-293T C147(1.00)  LDD0919  [3]
 LDCM0322  AC59 HEK-293T C147(0.97)  LDD0920  [3]
 LDCM0323  AC6 HEK-293T C147(0.88)  LDD0921  [3]
 LDCM0324  AC60 HEK-293T C147(0.67)  LDD0922  [3]
 LDCM0325  AC61 HEK-293T C147(1.08)  LDD0923  [3]
 LDCM0326  AC62 HEK-293T C147(1.07)  LDD0924  [3]
 LDCM0327  AC63 HEK-293T C147(1.03)  LDD0925  [3]
 LDCM0328  AC64 HEK-293T C147(0.96)  LDD0926  [3]
 LDCM0329  AC65 HEK-293T C147(1.00)  LDD0927  [3]
 LDCM0330  AC66 HEK-293T C147(0.99)  LDD0928  [3]
 LDCM0331  AC67 HEK-293T C147(1.05)  LDD0929  [3]
 LDCM0332  AC68 PaTu 8988t C147(1.04)  LDD1211  [3]
 LDCM0333  AC69 PaTu 8988t C147(0.93)  LDD1212  [3]
 LDCM0334  AC7 HEK-293T C147(0.95)  LDD0932  [3]
 LDCM0335  AC70 PaTu 8988t C147(0.84)  LDD1214  [3]
 LDCM0336  AC71 PaTu 8988t C147(0.96)  LDD1215  [3]
 LDCM0337  AC72 PaTu 8988t C147(1.02)  LDD1216  [3]
 LDCM0338  AC73 PaTu 8988t C147(0.91)  LDD1217  [3]
 LDCM0339  AC74 PaTu 8988t C147(0.91)  LDD1218  [3]
 LDCM0340  AC75 PaTu 8988t C147(0.98)  LDD1219  [3]
 LDCM0341  AC76 PaTu 8988t C147(0.90)  LDD1220  [3]
 LDCM0342  AC77 PaTu 8988t C147(0.98)  LDD1221  [3]
 LDCM0343  AC78 PaTu 8988t C147(0.92)  LDD1222  [3]
 LDCM0344  AC79 PaTu 8988t C147(0.96)  LDD1223  [3]
 LDCM0345  AC8 HEK-293T C147(0.75)  LDD0943  [3]
 LDCM0346  AC80 PaTu 8988t C147(0.91)  LDD1225  [3]
 LDCM0347  AC81 PaTu 8988t C147(0.91)  LDD1226  [3]
 LDCM0348  AC82 PaTu 8988t C147(0.92)  LDD1227  [3]
 LDCM0365  AC98 HEK-293T C147(1.07)  LDD0963  [3]
 LDCM0366  AC99 HEK-293T C147(1.00)  LDD0964  [3]
 LDCM0248  AKOS034007472 HEK-293T C147(0.96)  LDD0846  [3]
 LDCM0356  AKOS034007680 HEK-293T C147(1.17)  LDD0954  [3]
 LDCM0275  AKOS034007705 HEK-293T C147(0.96)  LDD0873  [3]
 LDCM0156  Aniline NCI-H1299 11.71  LDD0403  [2]
 LDCM0020  ARS-1620 HCC44 C147(0.95)  LDD0078  [3]
 LDCM0367  CL1 PaTu 8988t C147(0.95)  LDD1246  [3]
 LDCM0368  CL10 PaTu 8988t C147(0.85)  LDD1247  [3]
 LDCM0369  CL100 HCT 116 C147(1.15)  LDD0686  [3]
 LDCM0370  CL101 HEK-293T C147(0.96)  LDD0968  [3]
 LDCM0371  CL102 HEK-293T C147(1.14)  LDD0969  [3]
 LDCM0372  CL103 HEK-293T C147(0.82)  LDD0970  [3]
 LDCM0373  CL104 HEK-293T C147(0.99)  LDD0971  [3]
 LDCM0374  CL105 HEK-293T C147(0.81)  LDD0972  [3]
 LDCM0375  CL106 HEK-293T C147(0.97)  LDD0973  [3]
 LDCM0376  CL107 HEK-293T C147(0.82)  LDD0974  [3]
 LDCM0377  CL108 HEK-293T C147(0.98)  LDD0975  [3]
 LDCM0378  CL109 HEK-293T C147(0.93)  LDD0976  [3]
 LDCM0379  CL11 PaTu 8988t C147(0.82)  LDD1258  [3]
 LDCM0380  CL110 HEK-293T C147(1.06)  LDD0978  [3]
 LDCM0381  CL111 HEK-293T C147(0.89)  LDD0979  [3]
 LDCM0382  CL112 HEK-293T C147(0.84)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C147(0.99)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C147(1.10)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C147(0.87)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C147(1.04)  LDD0984  [3]
 LDCM0387  CL117 HCT 116 C147(0.57)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C147(1.23)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C147(0.93)  LDD0706  [3]
 LDCM0390  CL12 PaTu 8988t C147(0.92)  LDD1269  [3]
 LDCM0391  CL120 HCT 116 C147(1.38)  LDD0708  [3]
 LDCM0392  CL121 HEK-293T C147(1.20)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C147(1.34)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C147(1.06)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C147(1.49)  LDD0993  [3]
 LDCM0396  CL125 HEK-293T C147(0.93)  LDD0994  [3]
 LDCM0397  CL126 HEK-293T C147(0.94)  LDD0995  [3]
 LDCM0398  CL127 HEK-293T C147(0.90)  LDD0996  [3]
 LDCM0399  CL128 HEK-293T C147(0.92)  LDD0997  [3]
 LDCM0400  CL13 PaTu 8988t C147(0.64)  LDD1279  [3]
 LDCM0401  CL14 PaTu 8988t C147(0.54)  LDD1280  [3]
 LDCM0402  CL15 PaTu 8988t C147(0.81)  LDD1281  [3]
 LDCM0403  CL16 HCT 116 C147(0.85)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C147(0.83)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C147(0.74)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C147(0.88)  LDD0723  [3]
 LDCM0407  CL2 PaTu 8988t C147(1.03)  LDD1286  [3]
 LDCM0408  CL20 HCT 116 C147(0.72)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C147(0.64)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C147(0.45)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C147(0.80)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C147(0.66)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C147(0.67)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C147(0.75)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C147(0.94)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C147(0.71)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C147(0.74)  LDD0734  [3]
 LDCM0418  CL3 PaTu 8988t C147(0.99)  LDD1297  [3]
 LDCM0419  CL30 HCT 116 C147(0.84)  LDD0736  [3]
 LDCM0420  CL31 HEK-293T C147(0.56)  LDD1018  [3]
 LDCM0421  CL32 HEK-293T C147(0.55)  LDD1019  [3]
 LDCM0422  CL33 HEK-293T C147(1.65)  LDD1020  [3]
 LDCM0423  CL34 HEK-293T C147(1.11)  LDD1021  [3]
 LDCM0424  CL35 HEK-293T C147(0.56)  LDD1022  [3]
 LDCM0425  CL36 HEK-293T C147(0.66)  LDD1023  [3]
 LDCM0426  CL37 HEK-293T C147(0.68)  LDD1024  [3]
 LDCM0428  CL39 HEK-293T C147(1.09)  LDD1026  [3]
 LDCM0429  CL4 PaTu 8988t C147(0.85)  LDD1308  [3]
 LDCM0430  CL40 HEK-293T C147(1.03)  LDD1028  [3]
 LDCM0431  CL41 HEK-293T C147(0.86)  LDD1029  [3]
 LDCM0432  CL42 HEK-293T C147(1.03)  LDD1030  [3]
 LDCM0433  CL43 HEK-293T C147(0.68)  LDD1031  [3]
 LDCM0434  CL44 HEK-293T C147(0.80)  LDD1032  [3]
 LDCM0435  CL45 HEK-293T C147(0.89)  LDD1033  [3]
 LDCM0436  CL46 PaTu 8988t C147(0.76)  LDD1315  [3]
 LDCM0437  CL47 PaTu 8988t C147(0.96)  LDD1316  [3]
 LDCM0438  CL48 PaTu 8988t C147(0.96)  LDD1317  [3]
 LDCM0439  CL49 PaTu 8988t C147(1.01)  LDD1318  [3]
 LDCM0440  CL5 PaTu 8988t C147(0.69)  LDD1319  [3]
 LDCM0441  CL50 PaTu 8988t C147(0.86)  LDD1320  [3]
 LDCM0442  CL51 PaTu 8988t C147(0.94)  LDD1321  [3]
 LDCM0443  CL52 PaTu 8988t C147(1.03)  LDD1322  [3]
 LDCM0444  CL53 PaTu 8988t C147(0.94)  LDD1323  [3]
 LDCM0445  CL54 PaTu 8988t C147(0.72)  LDD1324  [3]
 LDCM0446  CL55 PaTu 8988t C147(0.96)  LDD1325  [3]
 LDCM0447  CL56 PaTu 8988t C147(0.53)  LDD1326  [3]
 LDCM0448  CL57 PaTu 8988t C147(0.72)  LDD1327  [3]
 LDCM0449  CL58 PaTu 8988t C147(0.72)  LDD1328  [3]
 LDCM0450  CL59 PaTu 8988t C147(0.82)  LDD1329  [3]
 LDCM0451  CL6 PaTu 8988t C147(0.79)  LDD1330  [3]
 LDCM0452  CL60 PaTu 8988t C147(0.78)  LDD1331  [3]
 LDCM0453  CL61 HCT 116 C147(1.22)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C147(0.99)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C147(1.19)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C147(1.07)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C147(1.34)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C147(0.90)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C147(1.00)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C147(0.94)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C147(0.88)  LDD0778  [3]
 LDCM0462  CL7 PaTu 8988t C147(0.69)  LDD1341  [3]
 LDCM0463  CL70 HCT 116 C147(1.04)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C147(1.06)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C147(1.43)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C147(0.98)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C147(1.08)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C147(0.93)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C147(0.82)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C147(1.19)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C147(0.94)  LDD0789  [3]
 LDCM0473  CL8 PaTu 8988t C147(0.96)  LDD1352  [3]
 LDCM0474  CL80 HCT 116 C147(1.08)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C147(1.39)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C147(0.79)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C147(1.06)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C147(0.69)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C147(1.28)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C147(1.57)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C147(1.52)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C147(1.05)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C147(0.81)  LDD0800  [3]
 LDCM0484  CL9 PaTu 8988t C147(0.70)  LDD1363  [3]
 LDCM0485  CL90 HCT 116 C147(0.90)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C147(0.92)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C147(0.77)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C147(0.85)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C147(0.97)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C147(0.99)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C147(0.97)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C147(1.04)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C147(0.90)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C147(1.06)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C114(1.01); C147(1.21); C182(1.03)  LDD1698  [8]
 LDCM0468  Fragment33 HCT 116 C147(0.94)  LDD0785  [3]
 LDCM0427  Fragment51 HEK-293T C147(0.78)  LDD1025  [3]
 LDCM0022  KB02 HEK-293T C114(1.01); C147(0.89)  LDD1492  [8]
 LDCM0023  KB03 Jurkat C147(5.05)  LDD0209  [9]
 LDCM0024  KB05 Hs 936.T C147(2.88)  LDD3313  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ribonuclease P protein subunit p38 (RPP38) Eukaryotic ribosomal protein eL8 family P78345
Ribonuclease P protein subunit p14 (RPP14) Eukaryotic/archaeal RNase P protein component 2 family O95059
Ribonuclease P/MRP protein subunit POP5 (POP5) Eukaryotic/archaeal RNase P protein component 2 family Q969H6
Ribonuclease P protein subunit p25 (RPP25) Histone-like Alba family Q9BUL9
Ribonucleases P/MRP protein subunit POP1 (POP1) . Q99575

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
10 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840