Details of the Target

General Information of Target

Target ID LDTP01481
Target Name Centrosomal protein of 152 kDa (CEP152)
Gene Name CEP152
Gene ID 22995
Synonyms
KIAA0912; Centrosomal protein of 152 kDa; Cep152
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSLDFGSVALPVQNEDEEYDEEDYEREKELQQLLTDLPHDMLDDDLSSPELQYSDCSEDG
TDGQPHHPEQLEMSWNEQMLPKSQSVNGYNEIQSLYAGEKCGNVWEENRSKTEDRHPVYH
PEEGGDEGGSGYSPPSKCEQTDLYHLPENFRPYTNGQKQEFNNQATNVIKFSDPQWNHFQ
GPSCQGLEPYNKVTYKPYQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQIIQ
LQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER
EIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHE
SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEII
NKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDE
ISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKD
EFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTS
EKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMV
QDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELD
KLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQT
IKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLE
IELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRIS
FAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEW
NKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCL
DQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSK
WMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAG
HHAQPLALQATEAEADKKKVLEIKDLCCGHCFQELEKAKQECQDLKGKLEKCCRHLQHLE
RKHKAVVEKIGEENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACLPCSG
GALEELRGQYIKAVKKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYLICLQ
QILQDDGKEGAEKKIMNAASKLATMAKLLETPISSKSQSKTTQSALPLTSEMLIAVKKSK
RNDVNQKIPCCIESKSNSVNTITRTLCEQAPKRRAACNLQRLLENSEHQSIKHVGSKETH
LEFQFGDGSCKHLNSLPRNVSPEFVPCEGEGGFGLHKKKDLLSDNGSESLPHSAAYPFLG
TLGNKPSPRCTPGPSESGCMHITFRDSNERLGLKVYKCNPLMESENAASEKSQGLDVQEP
PVKDGGDLSDCLGWPSSSATLSFDSREASFVHGRPQGTLEIPSESVKSKQFSPSGYLSDT
EESNMICQTMKCQRYQTPYLSEETTYLEPGKISVNCGHPSRHKADRLKSDFKKLSSTLPS
SVCQQPSRKLIVPLSSQQDSGFDSPFVNLD
Target Bioclass
Other
Family
CEP152 family
Subcellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Function
Necessary for centrosome duplication; the function seems also to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecules involved in centriole formation. Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure. Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Overexpression of CEP152 can drive amplification of centrioles.
Uniprot ID
O94986
Ensemble ID
ENST00000325747.9
HGNC ID
HGNC:29298

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C1361(5.04)  LDD1703  [1]
DBIA
 Probe Info  		C1168(1.01); C1171(1.01); C1390(0.94); C1391(0.94)  LDD0078  [2]
IPM
 Probe Info  		N.A.  LDD0147  [3]
TFBX
 Probe Info  		N.A.  LDD0148  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C1417(0.92)  LDD1507  [4]
 LDCM0215  AC10 PaTu 8988t C101(0.82)  LDD1094  [2]
 LDCM0216  AC100 HCT 116 C1390(1.27); C1391(1.27)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C1390(1.27); C1391(1.27)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C1390(1.16); C1391(1.16)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C1390(1.39); C1391(1.39)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C1390(1.16); C1391(1.16)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C1390(1.45); C1391(1.45)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C1390(1.54); C1391(1.54)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C1390(1.29); C1391(1.29)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C1390(1.41); C1391(1.41)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C1390(1.08); C1391(1.08)  LDD0542  [2]
 LDCM0226  AC11 PaTu 8988t C101(0.65)  LDD1105  [2]
 LDCM0227  AC110 HCT 116 C1390(1.41); C1391(1.41)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C1390(1.39); C1391(1.39)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C1390(1.52); C1391(1.52)  LDD0546  [2]
 LDCM0230  AC113 PaTu 8988t C101(0.88)  LDD1109  [2]
 LDCM0231  AC114 PaTu 8988t C101(1.04)  LDD1110  [2]
 LDCM0232  AC115 PaTu 8988t C101(0.92)  LDD1111  [2]
 LDCM0233  AC116 PaTu 8988t C101(1.06)  LDD1112  [2]
 LDCM0234  AC117 PaTu 8988t C101(1.30)  LDD1113  [2]
 LDCM0235  AC118 PaTu 8988t C101(0.98)  LDD1114  [2]
 LDCM0236  AC119 PaTu 8988t C101(0.71)  LDD1115  [2]
 LDCM0237  AC12 PaTu 8988t C101(0.59)  LDD1116  [2]
 LDCM0238  AC120 PaTu 8988t C101(0.96)  LDD1117  [2]
 LDCM0239  AC121 PaTu 8988t C101(1.38)  LDD1118  [2]
 LDCM0240  AC122 PaTu 8988t C101(0.98)  LDD1119  [2]
 LDCM0241  AC123 PaTu 8988t C101(0.66)  LDD1120  [2]
 LDCM0242  AC124 PaTu 8988t C101(0.94)  LDD1121  [2]
 LDCM0243  AC125 PaTu 8988t C101(0.93)  LDD1122  [2]
 LDCM0244  AC126 PaTu 8988t C101(0.83)  LDD1123  [2]
 LDCM0245  AC127 PaTu 8988t C101(1.10)  LDD1124  [2]
 LDCM0259  AC14 PaTu 8988t C101(0.61)  LDD1138  [2]
 LDCM0263  AC143 HEK-293T C1258(1.06)  LDD0861  [2]
 LDCM0264  AC144 HEK-293T C1258(1.48)  LDD0862  [2]
 LDCM0265  AC145 HEK-293T C1258(1.30)  LDD0863  [2]
 LDCM0266  AC146 HEK-293T C1258(2.22)  LDD0864  [2]
 LDCM0267  AC147 HEK-293T C1258(1.89)  LDD0865  [2]
 LDCM0268  AC148 HEK-293T C1258(0.94)  LDD0866  [2]
 LDCM0269  AC149 HEK-293T C1258(1.06)  LDD0867  [2]
 LDCM0270  AC15 PaTu 8988t C101(0.86)  LDD1149  [2]
 LDCM0271  AC150 HEK-293T C1258(1.47)  LDD0869  [2]
 LDCM0272  AC151 HEK-293T C1258(1.35)  LDD0870  [2]
 LDCM0273  AC152 HEK-293T C1258(1.54)  LDD0871  [2]
 LDCM0274  AC153 HEK-293T C1258(1.21)  LDD0872  [2]
 LDCM0621  AC154 HEK-293T C1258(1.14)  LDD2162  [2]
 LDCM0622  AC155 HEK-293T C1258(1.47)  LDD2163  [2]
 LDCM0623  AC156 HEK-293T C1258(1.77)  LDD2164  [2]
 LDCM0624  AC157 HEK-293T C1258(1.78)  LDD2165  [2]
 LDCM0276  AC17 PaTu 8988t C101(1.13)  LDD1155  [2]
 LDCM0277  AC18 PaTu 8988t C101(1.26)  LDD1156  [2]
 LDCM0278  AC19 PaTu 8988t C101(1.07)  LDD1157  [2]
 LDCM0279  AC2 HEK-293T C1407(1.07)  LDD1518  [4]
 LDCM0280  AC20 PaTu 8988t C101(2.23)  LDD1159  [2]
 LDCM0281  AC21 PaTu 8988t C101(1.76)  LDD1160  [2]
 LDCM0282  AC22 PaTu 8988t C101(1.51)  LDD1161  [2]
 LDCM0283  AC23 PaTu 8988t C101(1.54)  LDD1162  [2]
 LDCM0284  AC24 PaTu 8988t C101(1.49)  LDD1163  [2]
 LDCM0285  AC25 PaTu 8988t C101(1.38)  LDD1164  [2]
 LDCM0286  AC26 PaTu 8988t C101(1.54)  LDD1165  [2]
 LDCM0287  AC27 PaTu 8988t C101(1.68)  LDD1166  [2]
 LDCM0288  AC28 PaTu 8988t C101(1.21)  LDD1167  [2]
 LDCM0289  AC29 PaTu 8988t C101(1.07)  LDD1168  [2]
 LDCM0290  AC3 HEK-293T C1417(0.85); C1407(1.03); C848(0.97)  LDD1529  [4]
 LDCM0291  AC30 PaTu 8988t C101(0.98)  LDD1170  [2]
 LDCM0292  AC31 PaTu 8988t C101(1.06)  LDD1171  [2]
 LDCM0293  AC32 PaTu 8988t C101(0.80)  LDD1172  [2]
 LDCM0294  AC33 PaTu 8988t C101(1.76)  LDD1173  [2]
 LDCM0295  AC34 PaTu 8988t C101(1.18)  LDD1174  [2]
 LDCM0296  AC35 HEK-293T C395(1.54)  LDD0894  [2]
 LDCM0297  AC36 HEK-293T C395(2.44)  LDD0895  [2]
 LDCM0298  AC37 HEK-293T C395(2.80)  LDD0896  [2]
 LDCM0299  AC38 HEK-293T C395(2.00)  LDD0897  [2]
 LDCM0300  AC39 HEK-293T C395(1.60)  LDD0898  [2]
 LDCM0301  AC4 HEK-293T C1417(1.00)  LDD1540  [4]
 LDCM0302  AC40 HEK-293T C395(1.98)  LDD0900  [2]
 LDCM0303  AC41 HEK-293T C395(1.41)  LDD0901  [2]
 LDCM0304  AC42 HEK-293T C395(1.38)  LDD0902  [2]
 LDCM0305  AC43 HEK-293T C395(1.36)  LDD0903  [2]
 LDCM0306  AC44 HEK-293T C395(1.82)  LDD0904  [2]
 LDCM0307  AC45 HEK-293T C395(3.15)  LDD0905  [2]
 LDCM0308  AC46 HEK-293T C395(0.99)  LDD0906  [2]
 LDCM0309  AC47 HEK-293T C395(1.42)  LDD0907  [2]
 LDCM0310  AC48 HEK-293T C395(1.42)  LDD0908  [2]
 LDCM0311  AC49 HEK-293T C395(1.50)  LDD0909  [2]
 LDCM0313  AC50 HEK-293T C395(1.67)  LDD0911  [2]
 LDCM0314  AC51 HEK-293T C395(2.64)  LDD0912  [2]
 LDCM0315  AC52 HEK-293T C395(2.44)  LDD0913  [2]
 LDCM0316  AC53 HEK-293T C395(2.42)  LDD0914  [2]
 LDCM0317  AC54 HEK-293T C395(2.44)  LDD0915  [2]
 LDCM0318  AC55 HEK-293T C395(1.72)  LDD0916  [2]
 LDCM0319  AC56 HEK-293T C395(1.66)  LDD0917  [2]
 LDCM0320  AC57 HEK-293T C101(0.70); C395(1.16)  LDD0918  [2]
 LDCM0321  AC58 HEK-293T C101(0.77); C395(1.03)  LDD0919  [2]
 LDCM0322  AC59 HEK-293T C101(1.04); C395(1.19)  LDD0920  [2]
 LDCM0323  AC6 PaTu 8988t C101(0.68)  LDD1202  [2]
 LDCM0324  AC60 HEK-293T C101(0.52); C395(1.37)  LDD0922  [2]
 LDCM0325  AC61 HEK-293T C101(0.82); C395(2.25)  LDD0923  [2]
 LDCM0326  AC62 HEK-293T C101(0.78); C395(1.62)  LDD0924  [2]
 LDCM0327  AC63 HEK-293T C101(1.09); C395(1.64)  LDD0925  [2]
 LDCM0328  AC64 HEK-293T C101(1.06); C395(1.80)  LDD0926  [2]
 LDCM0329  AC65 HEK-293T C101(1.02); C395(2.35)  LDD0927  [2]
 LDCM0330  AC66 HEK-293T C101(1.01); C395(1.82)  LDD0928  [2]
 LDCM0331  AC67 HEK-293T C101(0.83); C395(1.73)  LDD0929  [2]
 LDCM0332  AC68 HCT 116 C1390(1.05); C1391(1.05)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C1390(1.23); C1391(1.23)  LDD0650  [2]
 LDCM0334  AC7 PaTu 8988t C101(0.37)  LDD1213  [2]
 LDCM0335  AC70 HCT 116 C1390(1.53); C1391(1.53)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C1390(1.00); C1391(1.00)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C1390(1.19); C1391(1.19)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C1390(1.53); C1391(1.53)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C1390(1.49); C1391(1.49)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C1390(1.71); C1391(1.71)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C1390(1.34); C1391(1.34)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C1390(1.27); C1391(1.27)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C1390(1.03); C1391(1.03)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C1390(1.16); C1391(1.16)  LDD0661  [2]
 LDCM0345  AC8 PaTu 8988t C101(0.38)  LDD1224  [2]
 LDCM0346  AC80 HCT 116 C1390(1.25); C1391(1.25)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C1390(0.70); C1391(0.70)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C1390(1.89); C1391(1.89)  LDD0665  [2]
 LDCM0349  AC83 HEK-293T C101(1.06); C1258(0.95)  LDD0947  [2]
 LDCM0350  AC84 HEK-293T C101(1.40); C1258(1.43)  LDD0948  [2]
 LDCM0351  AC85 HEK-293T C101(2.12); C1258(1.27)  LDD0949  [2]
 LDCM0352  AC86 HEK-293T C101(1.54); C1258(1.40)  LDD0950  [2]
 LDCM0353  AC87 HEK-293T C101(1.30); C1258(1.04)  LDD0951  [2]
 LDCM0354  AC88 HEK-293T C101(1.05); C1258(1.28)  LDD0952  [2]
 LDCM0355  AC89 HEK-293T C101(1.41); C1258(1.49)  LDD0953  [2]
 LDCM0357  AC90 HEK-293T C101(1.33); C1258(1.60)  LDD0955  [2]
 LDCM0358  AC91 HEK-293T C101(2.03); C1258(1.39)  LDD0956  [2]
 LDCM0359  AC92 HEK-293T C101(1.71); C1258(1.24)  LDD0957  [2]
 LDCM0360  AC93 HEK-293T C101(1.72); C1258(1.08)  LDD0958  [2]
 LDCM0361  AC94 HEK-293T C101(1.19); C1258(1.72)  LDD0959  [2]
 LDCM0362  AC95 HEK-293T C101(1.37); C1258(1.98)  LDD0960  [2]
 LDCM0363  AC96 HEK-293T C101(2.21); C1258(1.58)  LDD0961  [2]
 LDCM0364  AC97 HEK-293T C101(2.38); C1258(2.58)  LDD0962  [2]
 LDCM0365  AC98 HCT 116 C1390(1.43); C1391(1.43)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C1390(1.19); C1391(1.19)  LDD0683  [2]
 LDCM0248  AKOS034007472 PaTu 8988t C101(0.49)  LDD1127  [2]
 LDCM0356  AKOS034007680 PaTu 8988t C101(1.34)  LDD1235  [2]
 LDCM0275  AKOS034007705 PaTu 8988t C101(0.58)  LDD1154  [2]
 LDCM0020  ARS-1620 HCC44 C1168(1.01); C1171(1.01); C1390(0.94); C1391(0.94)  LDD0078  [2]
 LDCM0367  CL1 HCT 116 C1390(1.17); C1391(1.17)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C1390(1.14); C1391(1.14)  LDD0685  [2]
 LDCM0369  CL100 HEK-293T C1417(0.92); C1407(0.85)  LDD1573  [4]
 LDCM0370  CL101 PaTu 8988t C101(0.58)  LDD1249  [2]
 LDCM0371  CL102 PaTu 8988t C101(0.48)  LDD1250  [2]
 LDCM0372  CL103 PaTu 8988t C101(0.93)  LDD1251  [2]
 LDCM0373  CL104 PaTu 8988t C101(0.59)  LDD1252  [2]
 LDCM0374  CL105 PaTu 8988t C101(1.20)  LDD1253  [2]
 LDCM0375  CL106 PaTu 8988t C101(1.35)  LDD1254  [2]
 LDCM0376  CL107 PaTu 8988t C101(1.07)  LDD1255  [2]
 LDCM0377  CL108 PaTu 8988t C101(1.36)  LDD1256  [2]
 LDCM0378  CL109 PaTu 8988t C101(1.25)  LDD1257  [2]
 LDCM0379  CL11 HCT 116 C1390(1.15); C1391(1.15)  LDD0696  [2]
 LDCM0380  CL110 PaTu 8988t C101(1.76)  LDD1259  [2]
 LDCM0381  CL111 PaTu 8988t C101(1.79)  LDD1260  [2]
 LDCM0382  CL112 PaTu 8988t C101(0.99)  LDD1261  [2]
 LDCM0383  CL113 PaTu 8988t C101(1.02)  LDD1262  [2]
 LDCM0384  CL114 PaTu 8988t C101(0.75)  LDD1263  [2]
 LDCM0385  CL115 PaTu 8988t C101(0.79)  LDD1264  [2]
 LDCM0386  CL116 PaTu 8988t C101(1.24)  LDD1265  [2]
 LDCM0387  CL117 HEK-293T C395(2.57)  LDD0985  [2]
 LDCM0388  CL118 HEK-293T C395(2.40)  LDD0986  [2]
 LDCM0389  CL119 HEK-293T C395(1.51)  LDD0987  [2]
 LDCM0390  CL12 HCT 116 C1390(1.27); C1391(1.27)  LDD0707  [2]
 LDCM0391  CL120 HEK-293T C395(1.40)  LDD0989  [2]
 LDCM0392  CL121 HEK-293T C395(1.51)  LDD0990  [2]
 LDCM0393  CL122 HEK-293T C395(1.41)  LDD0991  [2]
 LDCM0394  CL123 HEK-293T C395(1.22)  LDD0992  [2]
 LDCM0395  CL124 HEK-293T C395(1.58)  LDD0993  [2]
 LDCM0396  CL125 HEK-293T C101(1.13); C395(0.95)  LDD0994  [2]
 LDCM0397  CL126 HEK-293T C101(0.72); C395(1.06)  LDD0995  [2]
 LDCM0398  CL127 HEK-293T C101(0.67); C395(0.96)  LDD0996  [2]
 LDCM0399  CL128 HEK-293T C101(0.96); C395(1.33)  LDD0997  [2]
 LDCM0400  CL13 HCT 116 C1390(1.10); C1391(1.10)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C1390(1.19); C1391(1.19)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C1390(1.28); C1391(1.28)  LDD0719  [2]
 LDCM0403  CL16 HEK-293T C1417(1.06); C1407(0.95)  LDD1607  [4]
 LDCM0404  CL17 HEK-293T C1417(3.19)  LDD1608  [4]
 LDCM0405  CL18 HEK-293T C1407(0.97)  LDD1609  [4]
 LDCM0406  CL19 HEK-293T C1417(1.01); C1407(1.02); C848(1.03)  LDD1610  [4]
 LDCM0407  CL2 HCT 116 C1390(1.08); C1391(1.08)  LDD0724  [2]
 LDCM0408  CL20 HEK-293T C1417(0.91)  LDD1612  [4]
 LDCM0410  CL22 HEK-293T C1417(1.11); C848(1.06)  LDD1614  [4]
 LDCM0411  CL23 HEK-293T C1417(1.07)  LDD1615  [4]
 LDCM0412  CL24 HEK-293T C1417(0.95)  LDD1616  [4]
 LDCM0414  CL26 HEK-293T C1417(0.91)  LDD1618  [4]
 LDCM0416  CL28 HEK-293T C1417(1.27); C1407(0.88)  LDD1620  [4]
 LDCM0417  CL29 HEK-293T C1417(0.95)  LDD1621  [4]
 LDCM0418  CL3 HCT 116 C1390(1.13); C1391(1.13)  LDD0735  [2]
 LDCM0419  CL30 HEK-293T C1407(1.05)  LDD1623  [4]
 LDCM0420  CL31 HEK-293T C1258(1.62)  LDD1018  [2]
 LDCM0421  CL32 HEK-293T C1258(1.22)  LDD1019  [2]
 LDCM0422  CL33 HEK-293T C1258(1.87)  LDD1020  [2]
 LDCM0423  CL34 HEK-293T C1258(0.96)  LDD1021  [2]
 LDCM0424  CL35 HEK-293T C1258(1.33)  LDD1022  [2]
 LDCM0425  CL36 HEK-293T C1258(0.98)  LDD1023  [2]
 LDCM0426  CL37 HEK-293T C1258(1.22)  LDD1024  [2]
 LDCM0428  CL39 HEK-293T C1258(1.91)  LDD1026  [2]
 LDCM0429  CL4 HCT 116 C1390(0.97); C1391(0.97)  LDD0746  [2]
 LDCM0430  CL40 HEK-293T C1258(1.26)  LDD1028  [2]
 LDCM0431  CL41 HEK-293T C1258(1.88)  LDD1029  [2]
 LDCM0432  CL42 HEK-293T C1258(1.55)  LDD1030  [2]
 LDCM0433  CL43 HEK-293T C1258(1.36)  LDD1031  [2]
 LDCM0434  CL44 HEK-293T C1258(1.05)  LDD1032  [2]
 LDCM0435  CL45 HEK-293T C1258(1.32)  LDD1033  [2]
 LDCM0436  CL46 HEK-293T C1258(1.73)  LDD1034  [2]
 LDCM0437  CL47 HEK-293T C1258(1.15)  LDD1035  [2]
 LDCM0438  CL48 HEK-293T C1258(0.99)  LDD1036  [2]
 LDCM0439  CL49 HEK-293T C1258(1.52)  LDD1037  [2]
 LDCM0440  CL5 HCT 116 C1390(1.14); C1391(1.14)  LDD0757  [2]
 LDCM0441  CL50 HEK-293T C1258(1.37)  LDD1039  [2]
 LDCM0442  CL51 HEK-293T C1258(1.25)  LDD1040  [2]
 LDCM0443  CL52 HEK-293T C1258(1.10)  LDD1041  [2]
 LDCM0444  CL53 HEK-293T C1258(1.13)  LDD1042  [2]
 LDCM0445  CL54 HEK-293T C1258(1.01)  LDD1043  [2]
 LDCM0446  CL55 HEK-293T C1258(1.09)  LDD1044  [2]
 LDCM0447  CL56 HEK-293T C1258(0.92)  LDD1045  [2]
 LDCM0448  CL57 HEK-293T C1258(1.31)  LDD1046  [2]
 LDCM0449  CL58 HEK-293T C1258(0.86)  LDD1047  [2]
 LDCM0450  CL59 HEK-293T C1258(1.48)  LDD1048  [2]
 LDCM0451  CL6 HCT 116 C1390(1.35); C1391(1.35)  LDD0768  [2]
 LDCM0452  CL60 HEK-293T C1258(1.84)  LDD1050  [2]
 LDCM0453  CL61 HEK-293T C1258(1.56)  LDD1051  [2]
 LDCM0454  CL62 HEK-293T C1258(1.55)  LDD1052  [2]
 LDCM0455  CL63 HEK-293T C1258(2.02)  LDD1053  [2]
 LDCM0456  CL64 HEK-293T C1258(1.46)  LDD1054  [2]
 LDCM0457  CL65 HEK-293T C1258(1.26)  LDD1055  [2]
 LDCM0458  CL66 HEK-293T C1258(1.45)  LDD1056  [2]
 LDCM0459  CL67 HEK-293T C1258(1.10)  LDD1057  [2]
 LDCM0460  CL68 HEK-293T C1258(1.14)  LDD1058  [2]
 LDCM0461  CL69 HEK-293T C1258(1.04)  LDD1059  [2]
 LDCM0462  CL7 HCT 116 C1390(1.15); C1391(1.15)  LDD0779  [2]
 LDCM0463  CL70 HEK-293T C1258(1.20)  LDD1061  [2]
 LDCM0464  CL71 HEK-293T C1258(1.34)  LDD1062  [2]
 LDCM0465  CL72 HEK-293T C1258(1.18)  LDD1063  [2]
 LDCM0466  CL73 HEK-293T C1258(0.91)  LDD1064  [2]
 LDCM0467  CL74 HEK-293T C1258(2.21)  LDD1065  [2]
 LDCM0469  CL76 HCT 116 C1390(0.79); C1391(0.79)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C1390(0.80); C1391(0.80)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C1390(0.94); C1391(0.94)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C1390(0.81); C1391(0.81)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C1390(1.48); C1391(1.48)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C1390(0.81); C1391(0.81)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C1390(0.77); C1391(0.77)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C1390(0.76); C1391(0.76)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C1390(0.85); C1391(0.85)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C1390(0.85); C1391(0.85)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C1390(0.87); C1391(0.87)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C1390(0.78); C1391(0.78)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C1390(0.87); C1391(0.87)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C1390(0.83); C1391(0.83)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C1390(0.85); C1391(0.85)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C1390(0.95); C1391(0.95)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C1390(1.31); C1391(1.31)  LDD0802  [2]
 LDCM0486  CL91 HEK-293T C1417(1.03); C1407(0.97); C848(1.09)  LDD1689  [4]
 LDCM0487  CL92 HEK-293T C1417(1.25)  LDD1690  [4]
 LDCM0489  CL94 HEK-293T C1417(1.12); C848(1.02)  LDD1692  [4]
 LDCM0490  CL95 HEK-293T C1417(2.34)  LDD1693  [4]
 LDCM0491  CL96 HEK-293T C1417(1.43)  LDD1694  [4]
 LDCM0493  CL98 HEK-293T C1417(1.01)  LDD1696  [4]
 LDCM0468  Fragment33 HEK-293T C1258(1.82)  LDD1066  [2]
 LDCM0427  Fragment51 HEK-293T C1258(1.01)  LDD1025  [2]
 LDCM0022  KB02 HCT 116 C101(1.71)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C101(1.22)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C101(1.59)  LDD0082  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine/threonine-protein kinase PLK4 (PLK4) Ser/Thr protein kinase family O00444
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Centrosomal protein of 131 kDa (CEP131) CEP131 family Q9UPN4
Centrosomal protein of 135 kDa (CEP135) CEP135/TSGA10 family Q66GS9

References

1 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402