Details of the Target

General Information of Target

Target ID LDTP01443
Target Name F-BAR and double SH3 domains protein 2 (FCHSD2)
Gene Name FCHSD2
Gene ID 9873
Synonyms
KIAA0769; SH3MD3; F-BAR and double SH3 domains protein 2; Carom; Protein nervous wreck 1; NWK1; SH3 multiple domains protein 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQPPPRKVKVTQELKNIQVEQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGMQKL
ASQYLKRDWPGVKADDRNDYRSMYPVWKSFLEGTMQVAQSRMNICENYKNFISEPARTVR
SLKEQQLKRCVDQLTKIQTELQETVKDLAKGKKKYFETEQMAHAVREKADIEAKSKLSLF
QSRISLQKASVKLKARRSECNSKATHARNDYLLTLAAANAHQDRYYQTDLVNIMKALDGN
VYDHLKDYLIAFSRTELETCQAVQNTFQFLLENSSKVVRDYNLQLFLQENAVFHKPQPFQ
FQPCDSDTSRQLESETGTTEEHSLNKEARKWATRVAREHKNIVHQQRVLNDLECHGAAVS
EQSRAELEQKIDEARENIRKAEIIKLKAEARLDLLKQIGVSVDTWLKSAMNQVMEELENE
RWARPPAVTSNGTLHSLNADTEREEGEEFEDNMDVFDDSSSSPSGTLRNYPLTCKVVYSY
KASQPDELTIEEHEVLEVIEDGDMEDWVKARNKVGQVGYVPEKYLQFPTSNSLLSMLQSL
AALDSRSHTSSNSTEAELVSGSLNGDASVCFVKALYDYEGQTDDELSFPEGAIIRILNKE
NQDDDGFWEGEFNGRIGVFPSVLVEELSASENGDTPWMREIQISPSPKPHASLPPLPLYD
QPPSSPYPSPDKRSSLYFPRSPSANEKSLHAESPGFSQASRHTPETSYGKLRPVRAAPPP
PTQNHRRPAEKIEDVEITLV
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor. Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling. Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits. Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate. When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes.
Uniprot ID
O94868
Ensemble ID
ENST00000311172.11
HGNC ID
HGNC:29114

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.A207P; p.H725Y .
HEC1 Deletion: p.R129GfsTer6 .
MFE319 SNV: p.S190N; p.T466A .
SKHEP1 SNV: p.I594L .
SW1573 SNV: p.F269L .
TCCSUP SNV: p.E640Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C49(4.25)  LDD3310  [1]
1d-yne
 Probe Info  		N.A.  LDD0358  [2]
CY4
 Probe Info  		N.A.  LDD0247  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		C105(0.00); C354(0.00)  LDD0038  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		C354(0.00); C200(0.00)  LDD0037  [4]
IPM
 Probe Info  		N.A.  LDD2156  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C105(0.83)  LDD1093  [6]
 LDCM0215  AC10 HEK-293T C354(0.66)  LDD0813  [6]
 LDCM0216  AC100 HEK-293T C354(0.30)  LDD0814  [6]
 LDCM0217  AC101 HEK-293T C354(0.37)  LDD0815  [6]
 LDCM0218  AC102 HEK-293T C354(0.22)  LDD0816  [6]
 LDCM0219  AC103 HEK-293T C354(0.20)  LDD0817  [6]
 LDCM0220  AC104 HEK-293T C354(0.35)  LDD0818  [6]
 LDCM0221  AC105 HEK-293T C354(0.87)  LDD0819  [6]
 LDCM0222  AC106 HEK-293T C354(0.59)  LDD0820  [6]
 LDCM0223  AC107 HEK-293T C354(0.29)  LDD0821  [6]
 LDCM0224  AC108 HEK-293T C354(1.57)  LDD0822  [6]
 LDCM0225  AC109 HEK-293T C354(1.13)  LDD0823  [6]
 LDCM0226  AC11 HEK-293T C354(0.87)  LDD0824  [6]
 LDCM0227  AC110 HEK-293T C354(0.22)  LDD0825  [6]
 LDCM0228  AC111 HEK-293T C354(0.26)  LDD0826  [6]
 LDCM0229  AC112 HEK-293T C354(0.23)  LDD0827  [6]
 LDCM0230  AC113 HEK-293T C105(1.10); C354(1.06)  LDD0828  [6]
 LDCM0231  AC114 HEK-293T C105(0.87); C354(1.24)  LDD0829  [6]
 LDCM0232  AC115 HEK-293T C105(1.15); C354(1.04)  LDD0830  [6]
 LDCM0233  AC116 HEK-293T C105(0.86); C354(0.79)  LDD0831  [6]
 LDCM0234  AC117 HEK-293T C105(0.54); C354(0.38)  LDD0832  [6]
 LDCM0235  AC118 HEK-293T C105(0.35); C354(0.28)  LDD0833  [6]
 LDCM0236  AC119 HEK-293T C105(0.33); C354(0.21)  LDD0834  [6]
 LDCM0237  AC12 HEK-293T C354(0.68)  LDD0835  [6]
 LDCM0238  AC120 HEK-293T C105(0.61); C354(0.47)  LDD0836  [6]
 LDCM0239  AC121 HEK-293T C105(0.39); C354(0.25)  LDD0837  [6]
 LDCM0240  AC122 HEK-293T C105(0.36); C354(0.21)  LDD0838  [6]
 LDCM0241  AC123 HEK-293T C105(0.36); C354(0.19)  LDD0839  [6]
 LDCM0242  AC124 HEK-293T C105(0.38); C354(0.21)  LDD0840  [6]
 LDCM0243  AC125 HEK-293T C105(0.34); C354(0.24)  LDD0841  [6]
 LDCM0244  AC126 HEK-293T C105(0.40); C354(0.26)  LDD0842  [6]
 LDCM0245  AC127 HEK-293T C105(0.51); C354(0.24)  LDD0843  [6]
 LDCM0246  AC128 HEK-293T C354(1.21)  LDD0844  [6]
 LDCM0247  AC129 HEK-293T C354(0.45)  LDD0845  [6]
 LDCM0249  AC130 HEK-293T C354(0.48)  LDD0847  [6]
 LDCM0250  AC131 HEK-293T C354(0.90)  LDD0848  [6]
 LDCM0251  AC132 HEK-293T C354(0.60)  LDD0849  [6]
 LDCM0252  AC133 HEK-293T C354(0.18)  LDD0850  [6]
 LDCM0253  AC134 HEK-293T C354(0.21)  LDD0851  [6]
 LDCM0254  AC135 HEK-293T C354(0.33)  LDD0852  [6]
 LDCM0255  AC136 HEK-293T C354(0.31)  LDD0853  [6]
 LDCM0256  AC137 HEK-293T C354(0.19)  LDD0854  [6]
 LDCM0257  AC138 HEK-293T C354(0.21)  LDD0855  [6]
 LDCM0258  AC139 HEK-293T C354(0.19)  LDD0856  [6]
 LDCM0259  AC14 HEK-293T C354(0.54)  LDD0857  [6]
 LDCM0260  AC140 HEK-293T C354(0.19)  LDD0858  [6]
 LDCM0261  AC141 HEK-293T C354(0.16)  LDD0859  [6]
 LDCM0262  AC142 HEK-293T C354(0.16)  LDD0860  [6]
 LDCM0263  AC143 HEK-293T C354(0.75)  LDD0861  [6]
 LDCM0264  AC144 HEK-293T C354(0.35)  LDD0862  [6]
 LDCM0265  AC145 HEK-293T C354(0.29)  LDD0863  [6]
 LDCM0266  AC146 HEK-293T C354(0.26)  LDD0864  [6]
 LDCM0267  AC147 HEK-293T C354(0.31)  LDD0865  [6]
 LDCM0268  AC148 HEK-293T C354(0.26)  LDD0866  [6]
 LDCM0269  AC149 HEK-293T C354(0.72)  LDD0867  [6]
 LDCM0270  AC15 HEK-293T C354(0.27)  LDD0868  [6]
 LDCM0271  AC150 HEK-293T C354(0.26)  LDD0869  [6]
 LDCM0272  AC151 HEK-293T C354(0.27)  LDD0870  [6]
 LDCM0273  AC152 HEK-293T C354(0.32)  LDD0871  [6]
 LDCM0274  AC153 HEK-293T C354(0.23)  LDD0872  [6]
 LDCM0621  AC154 HEK-293T C354(0.42)  LDD2162  [6]
 LDCM0622  AC155 HEK-293T C354(0.50)  LDD2163  [6]
 LDCM0623  AC156 HEK-293T C354(0.36)  LDD2164  [6]
 LDCM0624  AC157 HEK-293T C354(0.35)  LDD2165  [6]
 LDCM0276  AC17 HEK-293T C105(0.58); C354(0.27)  LDD0874  [6]
 LDCM0277  AC18 HEK-293T C105(0.85); C354(0.64)  LDD0875  [6]
 LDCM0278  AC19 HEK-293T C105(1.09); C354(0.69)  LDD0876  [6]
 LDCM0279  AC2 PaTu 8988t C105(1.12)  LDD1158  [6]
 LDCM0280  AC20 HEK-293T C105(0.69); C354(0.30)  LDD0878  [6]
 LDCM0281  AC21 HEK-293T C105(0.73); C354(0.52)  LDD0879  [6]
 LDCM0282  AC22 HEK-293T C105(0.73); C354(0.39)  LDD0880  [6]
 LDCM0283  AC23 HEK-293T C105(0.39); C354(0.16)  LDD0881  [6]
 LDCM0284  AC24 HEK-293T C105(0.74); C354(0.44)  LDD0882  [6]
 LDCM0285  AC25 HEK-293T C354(0.36)  LDD0883  [6]
 LDCM0286  AC26 HEK-293T C354(0.44)  LDD0884  [6]
 LDCM0287  AC27 HEK-293T C354(0.48)  LDD0885  [6]
 LDCM0288  AC28 HEK-293T C354(0.56)  LDD0886  [6]
 LDCM0289  AC29 HEK-293T C354(0.41)  LDD0887  [6]
 LDCM0290  AC3 PaTu 8988t C105(1.05)  LDD1169  [6]
 LDCM0291  AC30 HEK-293T C354(0.53)  LDD0889  [6]
 LDCM0292  AC31 HEK-293T C354(0.65)  LDD0890  [6]
 LDCM0293  AC32 HEK-293T C354(0.39)  LDD0891  [6]
 LDCM0294  AC33 HEK-293T C354(0.40)  LDD0892  [6]
 LDCM0295  AC34 HEK-293T C354(0.53)  LDD0893  [6]
 LDCM0296  AC35 HEK-293T C105(2.02)  LDD0894  [6]
 LDCM0297  AC36 HEK-293T C105(1.69)  LDD0895  [6]
 LDCM0298  AC37 HEK-293T C105(1.37)  LDD0896  [6]
 LDCM0299  AC38 HEK-293T C105(1.45)  LDD0897  [6]
 LDCM0300  AC39 HEK-293T C105(1.25)  LDD0898  [6]
 LDCM0301  AC4 PaTu 8988t C105(0.85)  LDD1180  [6]
 LDCM0302  AC40 HEK-293T C105(0.96)  LDD0900  [6]
 LDCM0303  AC41 HEK-293T C105(1.01)  LDD0901  [6]
 LDCM0304  AC42 HEK-293T C105(0.92)  LDD0902  [6]
 LDCM0305  AC43 HEK-293T C105(0.68)  LDD0903  [6]
 LDCM0306  AC44 HEK-293T C105(0.83)  LDD0904  [6]
 LDCM0307  AC45 HEK-293T C105(1.16)  LDD0905  [6]
 LDCM0308  AC46 HEK-293T C105(0.98)  LDD0906  [6]
 LDCM0309  AC47 HEK-293T C105(0.89)  LDD0907  [6]
 LDCM0310  AC48 HEK-293T C105(0.97)  LDD0908  [6]
 LDCM0311  AC49 HEK-293T C105(0.69)  LDD0909  [6]
 LDCM0312  AC5 PaTu 8988t C105(1.07)  LDD1191  [6]
 LDCM0313  AC50 HEK-293T C105(0.99)  LDD0911  [6]
 LDCM0314  AC51 HEK-293T C105(0.79)  LDD0912  [6]
 LDCM0315  AC52 HEK-293T C105(0.75)  LDD0913  [6]
 LDCM0316  AC53 HEK-293T C105(1.25)  LDD0914  [6]
 LDCM0317  AC54 HEK-293T C105(0.73)  LDD0915  [6]
 LDCM0318  AC55 HEK-293T C105(0.85)  LDD0916  [6]
 LDCM0319  AC56 HEK-293T C105(0.93)  LDD0917  [6]
 LDCM0320  AC57 HEK-293T C105(1.11); C354(1.73)  LDD0918  [6]
 LDCM0321  AC58 HEK-293T C105(1.29); C354(1.84)  LDD0919  [6]
 LDCM0322  AC59 HEK-293T C105(1.10); C354(1.90)  LDD0920  [6]
 LDCM0323  AC6 HEK-293T C354(0.83)  LDD0921  [6]
 LDCM0324  AC60 HEK-293T C105(0.78); C354(1.77)  LDD0922  [6]
 LDCM0325  AC61 HEK-293T C105(1.01); C354(0.80)  LDD0923  [6]
 LDCM0326  AC62 HEK-293T C105(1.35); C354(1.79)  LDD0924  [6]
 LDCM0327  AC63 HEK-293T C105(1.05); C354(1.15)  LDD0925  [6]
 LDCM0328  AC64 HEK-293T C105(1.39); C354(1.85)  LDD0926  [6]
 LDCM0329  AC65 HEK-293T C105(1.08); C354(0.98)  LDD0927  [6]
 LDCM0330  AC66 HEK-293T C105(1.50); C354(1.41)  LDD0928  [6]
 LDCM0331  AC67 HEK-293T C105(1.16); C354(1.07)  LDD0929  [6]
 LDCM0332  AC68 HEK-293T C354(0.80)  LDD0930  [6]
 LDCM0333  AC69 HEK-293T C354(0.96)  LDD0931  [6]
 LDCM0334  AC7 HEK-293T C354(0.95)  LDD0932  [6]
 LDCM0335  AC70 HEK-293T C354(0.57)  LDD0933  [6]
 LDCM0336  AC71 HEK-293T C354(0.69)  LDD0934  [6]
 LDCM0337  AC72 HEK-293T C354(0.59)  LDD0935  [6]
 LDCM0338  AC73 HEK-293T C354(0.70)  LDD0936  [6]
 LDCM0339  AC74 HEK-293T C354(0.85)  LDD0937  [6]
 LDCM0340  AC75 HEK-293T C354(0.58)  LDD0938  [6]
 LDCM0341  AC76 HEK-293T C354(0.83)  LDD0939  [6]
 LDCM0342  AC77 HEK-293T C354(0.52)  LDD0940  [6]
 LDCM0343  AC78 HEK-293T C354(0.64)  LDD0941  [6]
 LDCM0344  AC79 HEK-293T C354(0.81)  LDD0942  [6]
 LDCM0345  AC8 HEK-293T C354(0.35)  LDD0943  [6]
 LDCM0346  AC80 HEK-293T C354(0.55)  LDD0944  [6]
 LDCM0347  AC81 HEK-293T C354(0.89)  LDD0945  [6]
 LDCM0348  AC82 HEK-293T C354(0.27)  LDD0946  [6]
 LDCM0349  AC83 HEK-293T C105(0.86); C354(0.74)  LDD0947  [6]
 LDCM0350  AC84 HEK-293T C105(0.63); C354(0.61)  LDD0948  [6]
 LDCM0351  AC85 HEK-293T C105(1.14); C354(1.04)  LDD0949  [6]
 LDCM0352  AC86 HEK-293T C105(0.82); C354(0.97)  LDD0950  [6]
 LDCM0353  AC87 HEK-293T C105(0.68); C354(0.57)  LDD0951  [6]
 LDCM0354  AC88 HEK-293T C105(0.41); C354(0.41)  LDD0952  [6]
 LDCM0355  AC89 HEK-293T C105(0.30); C354(0.22)  LDD0953  [6]
 LDCM0357  AC90 HEK-293T C105(0.44); C354(0.31)  LDD0955  [6]
 LDCM0358  AC91 HEK-293T C105(0.60); C354(0.63)  LDD0956  [6]
 LDCM0359  AC92 HEK-293T C105(0.54); C354(0.59)  LDD0957  [6]
 LDCM0360  AC93 HEK-293T C105(0.66); C354(0.48)  LDD0958  [6]
 LDCM0361  AC94 HEK-293T C105(0.45); C354(0.35)  LDD0959  [6]
 LDCM0362  AC95 HEK-293T C105(0.53); C354(0.29)  LDD0960  [6]
 LDCM0363  AC96 HEK-293T C105(0.60); C354(0.42)  LDD0961  [6]
 LDCM0364  AC97 HEK-293T C105(0.32); C354(0.21)  LDD0962  [6]
 LDCM0365  AC98 HEK-293T C354(1.15)  LDD0963  [6]
 LDCM0366  AC99 HEK-293T C354(1.42)  LDD0964  [6]
 LDCM0248  AKOS034007472 HEK-293T C354(0.75)  LDD0846  [6]
 LDCM0356  AKOS034007680 HEK-293T C354(0.26)  LDD0954  [6]
 LDCM0275  AKOS034007705 HEK-293T C354(0.36)  LDD0873  [6]
 LDCM0367  CL1 HEK-293T C354(0.59)  LDD0965  [6]
 LDCM0368  CL10 HEK-293T C354(0.47)  LDD0966  [6]
 LDCM0369  CL100 PaTu 8988t C105(0.80)  LDD1248  [6]
 LDCM0370  CL101 HEK-293T C354(0.24)  LDD0968  [6]
 LDCM0371  CL102 HEK-293T C354(0.24)  LDD0969  [6]
 LDCM0372  CL103 HEK-293T C354(0.27)  LDD0970  [6]
 LDCM0373  CL104 HEK-293T C354(0.38)  LDD0971  [6]
 LDCM0374  CL105 HEK-293T C105(0.74); C354(0.71)  LDD0972  [6]
 LDCM0375  CL106 HEK-293T C105(0.82); C354(0.59)  LDD0973  [6]
 LDCM0376  CL107 HEK-293T C105(0.84); C354(0.62)  LDD0974  [6]
 LDCM0377  CL108 HEK-293T C105(0.80); C354(0.52)  LDD0975  [6]
 LDCM0378  CL109 HEK-293T C105(1.06); C354(0.65)  LDD0976  [6]
 LDCM0379  CL11 HEK-293T C354(0.33)  LDD0977  [6]
 LDCM0380  CL110 HEK-293T C105(0.74); C354(0.46)  LDD0978  [6]
 LDCM0381  CL111 HEK-293T C105(0.81); C354(0.56)  LDD0979  [6]
 LDCM0382  CL112 HEK-293T C354(0.46)  LDD0980  [6]
 LDCM0383  CL113 HEK-293T C354(1.55)  LDD0981  [6]
 LDCM0384  CL114 HEK-293T C354(0.15)  LDD0982  [6]
 LDCM0385  CL115 HEK-293T C354(0.29)  LDD0983  [6]
 LDCM0386  CL116 HEK-293T C354(0.30)  LDD0984  [6]
 LDCM0387  CL117 HEK-293T C105(1.93)  LDD0985  [6]
 LDCM0388  CL118 HEK-293T C105(1.32)  LDD0986  [6]
 LDCM0389  CL119 HEK-293T C105(1.15)  LDD0987  [6]
 LDCM0390  CL12 HEK-293T C354(0.89)  LDD0988  [6]
 LDCM0391  CL120 HEK-293T C105(0.92)  LDD0989  [6]
 LDCM0392  CL121 HEK-293T C105(0.86)  LDD0990  [6]
 LDCM0393  CL122 HEK-293T C105(0.86)  LDD0991  [6]
 LDCM0394  CL123 HEK-293T C105(0.81)  LDD0992  [6]
 LDCM0395  CL124 HEK-293T C105(0.88)  LDD0993  [6]
 LDCM0396  CL125 HEK-293T C105(1.13); C354(1.74)  LDD0994  [6]
 LDCM0397  CL126 HEK-293T C105(1.06); C354(2.48)  LDD0995  [6]
 LDCM0398  CL127 HEK-293T C105(1.16); C354(1.47)  LDD0996  [6]
 LDCM0399  CL128 HEK-293T C105(1.14); C354(1.64)  LDD0997  [6]
 LDCM0400  CL13 HEK-293T C354(0.74)  LDD0998  [6]
 LDCM0401  CL14 HEK-293T C354(0.83)  LDD0999  [6]
 LDCM0402  CL15 HEK-293T C354(0.37)  LDD1000  [6]
 LDCM0403  CL16 PaTu 8988t C105(1.00)  LDD1282  [6]
 LDCM0404  CL17 PaTu 8988t C105(1.01)  LDD1283  [6]
 LDCM0405  CL18 PaTu 8988t C105(0.95)  LDD1284  [6]
 LDCM0406  CL19 PaTu 8988t C105(1.06)  LDD1285  [6]
 LDCM0407  CL2 HEK-293T C354(0.69)  LDD1005  [6]
 LDCM0408  CL20 PaTu 8988t C105(1.11)  LDD1287  [6]
 LDCM0409  CL21 PaTu 8988t C105(1.12)  LDD1288  [6]
 LDCM0410  CL22 PaTu 8988t C105(1.18)  LDD1289  [6]
 LDCM0411  CL23 PaTu 8988t C105(0.92)  LDD1290  [6]
 LDCM0412  CL24 PaTu 8988t C105(0.94)  LDD1291  [6]
 LDCM0413  CL25 PaTu 8988t C105(0.83)  LDD1292  [6]
 LDCM0414  CL26 PaTu 8988t C105(1.03)  LDD1293  [6]
 LDCM0415  CL27 PaTu 8988t C105(0.84)  LDD1294  [6]
 LDCM0416  CL28 PaTu 8988t C105(1.03)  LDD1295  [6]
 LDCM0417  CL29 PaTu 8988t C105(1.08)  LDD1296  [6]
 LDCM0418  CL3 HEK-293T C354(1.75)  LDD1016  [6]
 LDCM0419  CL30 PaTu 8988t C105(1.14)  LDD1298  [6]
 LDCM0420  CL31 HEK-293T C105(0.52); C354(0.47)  LDD1018  [6]
 LDCM0421  CL32 HEK-293T C105(0.73); C354(0.68)  LDD1019  [6]
 LDCM0422  CL33 HEK-293T C105(0.54); C354(0.55)  LDD1020  [6]
 LDCM0423  CL34 HEK-293T C105(0.72); C354(1.02)  LDD1021  [6]
 LDCM0424  CL35 HEK-293T C105(0.79); C354(0.49)  LDD1022  [6]
 LDCM0425  CL36 HEK-293T C105(0.79); C354(0.44)  LDD1023  [6]
 LDCM0426  CL37 HEK-293T C105(0.66); C354(0.45)  LDD1024  [6]
 LDCM0428  CL39 HEK-293T C105(0.20); C354(0.07)  LDD1026  [6]
 LDCM0429  CL4 HEK-293T C354(1.58)  LDD1027  [6]
 LDCM0430  CL40 HEK-293T C105(0.71); C354(0.65)  LDD1028  [6]
 LDCM0431  CL41 HEK-293T C105(0.21); C354(0.09)  LDD1029  [6]
 LDCM0432  CL42 HEK-293T C105(0.20); C354(0.08)  LDD1030  [6]
 LDCM0433  CL43 HEK-293T C105(0.23); C354(0.09)  LDD1031  [6]
 LDCM0434  CL44 HEK-293T C105(0.68); C354(0.65)  LDD1032  [6]
 LDCM0435  CL45 HEK-293T C105(0.29); C354(0.12)  LDD1033  [6]
 LDCM0436  CL46 HEK-293T C105(0.50)  LDD1034  [6]
 LDCM0437  CL47 HEK-293T C105(0.76)  LDD1035  [6]
 LDCM0438  CL48 HEK-293T C105(0.79)  LDD1036  [6]
 LDCM0439  CL49 HEK-293T C105(0.73)  LDD1037  [6]
 LDCM0440  CL5 HEK-293T C354(1.06)  LDD1038  [6]
 LDCM0441  CL50 HEK-293T C105(0.25)  LDD1039  [6]
 LDCM0442  CL51 HEK-293T C105(0.56)  LDD1040  [6]
 LDCM0443  CL52 HEK-293T C105(1.16)  LDD1041  [6]
 LDCM0444  CL53 HEK-293T C105(0.71)  LDD1042  [6]
 LDCM0445  CL54 HEK-293T C105(0.61)  LDD1043  [6]
 LDCM0446  CL55 HEK-293T C105(0.43)  LDD1044  [6]
 LDCM0447  CL56 HEK-293T C105(0.93)  LDD1045  [6]
 LDCM0448  CL57 HEK-293T C105(0.63)  LDD1046  [6]
 LDCM0449  CL58 HEK-293T C105(0.71)  LDD1047  [6]
 LDCM0450  CL59 HEK-293T C105(0.31)  LDD1048  [6]
 LDCM0451  CL6 HEK-293T C354(1.21)  LDD1049  [6]
 LDCM0452  CL60 HEK-293T C105(0.22)  LDD1050  [6]
 LDCM0453  CL61 HEK-293T C105(0.76)  LDD1051  [6]
 LDCM0454  CL62 HEK-293T C105(0.77)  LDD1052  [6]
 LDCM0455  CL63 HEK-293T C105(0.58)  LDD1053  [6]
 LDCM0456  CL64 HEK-293T C105(0.66)  LDD1054  [6]
 LDCM0457  CL65 HEK-293T C105(0.68)  LDD1055  [6]
 LDCM0458  CL66 HEK-293T C105(0.72)  LDD1056  [6]
 LDCM0459  CL67 HEK-293T C105(0.79)  LDD1057  [6]
 LDCM0460  CL68 HEK-293T C105(0.70)  LDD1058  [6]
 LDCM0461  CL69 HEK-293T C105(0.79)  LDD1059  [6]
 LDCM0462  CL7 HEK-293T C354(0.58)  LDD1060  [6]
 LDCM0463  CL70 HEK-293T C105(0.98)  LDD1061  [6]
 LDCM0464  CL71 HEK-293T C105(0.93)  LDD1062  [6]
 LDCM0465  CL72 HEK-293T C105(0.89)  LDD1063  [6]
 LDCM0466  CL73 HEK-293T C105(0.66)  LDD1064  [6]
 LDCM0467  CL74 HEK-293T C105(0.26)  LDD1065  [6]
 LDCM0469  CL76 PaTu 8988t C105(0.88)  LDD1348  [6]
 LDCM0470  CL77 PaTu 8988t C105(0.85)  LDD1349  [6]
 LDCM0471  CL78 PaTu 8988t C105(1.01)  LDD1350  [6]
 LDCM0472  CL79 PaTu 8988t C105(0.98)  LDD1351  [6]
 LDCM0473  CL8 HEK-293T C354(0.63)  LDD1071  [6]
 LDCM0474  CL80 PaTu 8988t C105(0.89)  LDD1353  [6]
 LDCM0475  CL81 PaTu 8988t C105(0.75)  LDD1354  [6]
 LDCM0476  CL82 PaTu 8988t C105(0.84)  LDD1355  [6]
 LDCM0477  CL83 PaTu 8988t C105(0.76)  LDD1356  [6]
 LDCM0478  CL84 PaTu 8988t C105(0.88)  LDD1357  [6]
 LDCM0479  CL85 PaTu 8988t C105(0.79)  LDD1358  [6]
 LDCM0480  CL86 PaTu 8988t C105(0.82)  LDD1359  [6]
 LDCM0481  CL87 PaTu 8988t C105(0.87)  LDD1360  [6]
 LDCM0482  CL88 PaTu 8988t C105(0.95)  LDD1361  [6]
 LDCM0483  CL89 PaTu 8988t C105(0.91)  LDD1362  [6]
 LDCM0484  CL9 HEK-293T C354(0.60)  LDD1082  [6]
 LDCM0485  CL90 PaTu 8988t C105(0.84)  LDD1364  [6]
 LDCM0486  CL91 PaTu 8988t C105(0.89)  LDD1365  [6]
 LDCM0487  CL92 PaTu 8988t C105(0.75)  LDD1366  [6]
 LDCM0488  CL93 PaTu 8988t C105(1.13)  LDD1367  [6]
 LDCM0489  CL94 PaTu 8988t C105(1.00)  LDD1368  [6]
 LDCM0490  CL95 PaTu 8988t C105(0.83)  LDD1369  [6]
 LDCM0491  CL96 PaTu 8988t C105(0.94)  LDD1370  [6]
 LDCM0492  CL97 PaTu 8988t C105(1.07)  LDD1371  [6]
 LDCM0493  CL98 PaTu 8988t C105(1.20)  LDD1372  [6]
 LDCM0494  CL99 PaTu 8988t C105(0.92)  LDD1373  [6]
 LDCM0495  E2913 HEK-293T C354(0.95); C130(1.23)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C105(0.42)  LDD1066  [6]
 LDCM0427  Fragment51 HEK-293T C105(0.55); C354(0.56)  LDD1025  [6]
 LDCM0022  KB02 HEK-293T C354(1.00)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C354(1.00)  LDD1497  [7]
 LDCM0024  KB05 COLO792 C49(4.25)  LDD3310  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transitional endoplasmic reticulum ATPase (VCP) AAA ATPase family P55072
Cyclin-dependent kinase 18 (CDK18) CMGC Ser/Thr protein kinase family Q07002
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
GTPase HRas (HRAS) Ras family P01112
Kinesin-like protein KIFC3 (KIFC3) Kinesin family Q9BVG8
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATP-binding cassette sub-family F member 3 (ABCF3) ABCF family Q9NUQ8
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
G-protein coupled receptor-associated sorting protein 2 (GPRASP2) GPRASP family Q96D09
Zinc finger protein 587 (ZNF587) Krueppel C2H2-type zinc-finger protein family Q96SQ5
Other
Click To Hide/Show 25 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATP synthase mitochondrial F1 complex assembly factor 2 (ATPAF2) ATP12 family Q8N5M1
BLOC-1-related complex subunit 6 (BORCS6) BORCS6 family Q96GS4
cAMP-dependent protein kinase type I-beta regulatory subunit (PRKAR1B) CAMP-dependent kinase regulatory chain family P31321
Cancer/testis antigen 1 (CTAG1A; CTAG1B) CTAG/PCC1 family P78358
Protein FAM9B (FAM9B) FAM9 family Q8IZU0
Homer protein homolog 1 (HOMER1) Homer family Q86YM7
Lebercilin-like protein (LCA5L) LCA5 family O95447
Protein LDOC1 (LDOC1) LDOC1 family O95751
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
Microfibrillar-associated protein 1 (MFAP1) MFAP1 family P55081
Meiosis-specific nuclear structural protein 1 (MNS1) MNS1 family Q8NEH6
MORF4 family-associated protein 1 (MRFAP1) MORF4 family-associated protein family Q9Y605
Microtubule-associated tumor suppressor candidate 2 (MTUS2) MTUS1 family Q5JR59
RAD50-interacting protein 1 (RINT1) RINT1 family Q6NUQ1
Gelsolin (GSN) Villin/gelsolin family P06396
Vacuolar protein sorting-associated protein 37C (VPS37C) VPS37 family A5D8V6
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 (ACAP1) . Q15027
Coiled-coil domain-containing protein 120 (CCDC120) . Q96HB5
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) . O14964
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (MAGI1) . Q96QZ7
SERTA domain-containing protein 3 (SERTAD3) . Q9UJW9
SH2 domain-containing protein 4A (SH2D4A) . Q9H788
Spindle assembly abnormal protein 6 homolog (SASS6) . Q6UVJ0
Testis-specific protein 10-interacting protein (TSGA10IP) . Q3SY00

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402