Details of the Target

General Information of Target

Target ID LDTP01264
Target Name Mediator of RNA polymerase II transcription subunit 6 (MED6)
Gene Name MED6
Gene ID 10001
Synonyms
ARC33; Mediator of RNA polymerase II transcription subunit 6; Activator-recruited cofactor 33 kDa component; ARC33; Mediator complex subunit 6; hMed6; Renal carcinoma antigen NY-REN-28
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAVDIRDNLLGISWVDSSWIPILNSGSVLDYFSERSNPFYDRTCNNEVVKMQRLTLEHL
NQMVGIEYILLHAQEPILFIIRKQQRQSPAQVIPLADYYIIAGVIYQAPDLGSVINSRVL
TAVHGIQSAFDEAMSYCRYHPSKGYWWHFKDHEEQDKVRPKAKRKEEPSSIFQRQRVDAL
LLDLRQKFPPKFVQLKPGEKPVPVDQTKKEAEPIPETVKPEEKETTKNVQQTVSAKGPPE
KRMRLQ
Target Bioclass
Other
Family
Mediator complex subunit 6 family
Subcellular location
Nucleus
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Uniprot ID
O75586
Ensemble ID
ENST00000256379.10
HGNC ID
HGNC:19970

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCC44 SNV: p.Q74Ter DBIA    Probe Info 
SNU1196 SNV: p.L24F DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C45(0.67)  LDD2089  [1]
DBIA
 Probe Info  		C45(0.83)  LDD0563  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		C137(0.00); C45(0.00)  LDD0038  [3]
IA-alkyne
 Probe Info  		C45(0.00); C137(0.00)  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		C45(0.00); C137(0.00)  LDD0037  [3]
TFBX
 Probe Info  		N.A.  LDD0027  [4]
AOyne
 Probe Info  		15.00  LDD0443  [5]
NAIA_5
 Probe Info  		C45(0.00); C137(0.00)  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C45(0.94)  LDD2117  [1]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C45(0.80)  LDD2131  [1]
 LDCM0214  AC1 PaTu 8988t C45(0.21)  LDD1093  [2]
 LDCM0215  AC10 HEK-293T C137(1.20); C45(1.20)  LDD0813  [2]
 LDCM0216  AC100 HEK-293T C137(1.13); C45(1.14)  LDD0814  [2]
 LDCM0217  AC101 HEK-293T C137(0.99); C45(0.96)  LDD0815  [2]
 LDCM0218  AC102 HEK-293T C137(1.17); C45(1.36)  LDD0816  [2]
 LDCM0219  AC103 HEK-293T C137(1.00); C45(1.03)  LDD0817  [2]
 LDCM0220  AC104 HEK-293T C137(0.99); C45(1.07)  LDD0818  [2]
 LDCM0221  AC105 HEK-293T C137(1.01); C45(1.04)  LDD0819  [2]
 LDCM0222  AC106 HEK-293T C137(0.90); C45(0.93)  LDD0820  [2]
 LDCM0223  AC107 HEK-293T C137(0.97); C45(0.96)  LDD0821  [2]
 LDCM0224  AC108 HEK-293T C137(0.93); C45(0.91)  LDD0822  [2]
 LDCM0225  AC109 HEK-293T C137(1.02); C45(0.98)  LDD0823  [2]
 LDCM0226  AC11 HEK-293T C137(1.18); C45(1.18)  LDD0824  [2]
 LDCM0227  AC110 HEK-293T C137(1.23); C45(1.17)  LDD0825  [2]
 LDCM0228  AC111 HEK-293T C137(1.50); C45(1.54)  LDD0826  [2]
 LDCM0229  AC112 HEK-293T C137(1.53); C45(1.59)  LDD0827  [2]
 LDCM0237  AC12 HEK-293T C137(0.93); C45(0.93)  LDD0835  [2]
 LDCM0246  AC128 HCT 116 C45(0.83)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C45(1.13)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C45(0.77)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C45(0.90)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C45(0.92)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C45(0.76)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C45(0.88)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C45(0.82)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C45(0.86)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C45(0.90)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C45(0.79)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C45(0.93)  LDD0575  [2]
 LDCM0259  AC14 HEK-293T C137(1.08); C45(1.08)  LDD0857  [2]
 LDCM0260  AC140 HCT 116 C45(0.90)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C45(1.36)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C45(1.64)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C45(0.62)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C45(0.40)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C45(0.41)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C45(0.44)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C45(0.39)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C45(0.47)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C45(0.45)  LDD0586  [2]
 LDCM0270  AC15 HEK-293T C137(1.30); C45(1.30)  LDD0868  [2]
 LDCM0271  AC150 HCT 116 C45(0.42)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C45(0.56)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C45(0.52)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C45(0.41)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C45(0.39)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C45(0.36)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C45(0.57)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C45(0.54)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C45(0.82)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C45(0.73)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C45(0.78)  LDD0595  [2]
 LDCM0279  AC2 PaTu 8988t C45(0.30)  LDD1158  [2]
 LDCM0280  AC20 HCT 116 C45(1.02)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C45(0.75)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C45(0.81)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C45(0.83)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C45(0.92)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C137(0.87)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C137(0.82)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C137(0.80)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C137(0.85)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C137(0.84)  LDD0606  [2]
 LDCM0290  AC3 PaTu 8988t C45(0.22)  LDD1169  [2]
 LDCM0291  AC30 HCT 116 C137(0.86)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C137(0.77)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C137(0.76)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C137(0.78)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C137(0.86)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C137(1.03)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C137(0.83)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C137(0.92)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C137(0.86)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C137(0.97)  LDD0617  [2]
 LDCM0301  AC4 PaTu 8988t C45(0.31)  LDD1180  [2]
 LDCM0302  AC40 HCT 116 C137(0.98)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C137(0.93)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C137(1.08)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C137(0.98)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C137(1.08)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C137(1.14)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C137(1.03); C45(1.44)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C137(0.93); C45(1.49)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C137(0.92); C45(1.43)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C45(0.74); C137(1.04)  LDD0628  [2]
 LDCM0312  AC5 PaTu 8988t C45(0.19)  LDD1191  [2]
 LDCM0313  AC50 HCT 116 C45(0.90); C137(1.09)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C137(1.00); C45(1.68)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C45(0.84); C137(0.97)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C45(0.75); C137(1.05)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C137(0.95); C45(1.00)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C137(1.11); C45(1.11)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C45(0.68); C137(1.36)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C45(0.49)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C45(0.52)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C45(0.56)  LDD0639  [2]
 LDCM0323  AC6 HEK-293T C137(0.92); C45(0.92)  LDD0921  [2]
 LDCM0324  AC60 HCT 116 C45(0.51)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C45(0.45)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C45(0.47)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C45(0.56)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C45(0.50)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C45(0.51)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C45(0.59)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C45(0.57)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C137(1.17)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C137(2.02)  LDD0650  [2]
 LDCM0334  AC7 HEK-293T C137(0.99); C45(0.99)  LDD0932  [2]
 LDCM0335  AC70 HCT 116 C137(1.33)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C137(1.23)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C137(1.47)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C137(1.63)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C137(1.48)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C137(1.48)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C137(1.67)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C137(1.46)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C137(1.53)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C137(1.34)  LDD0661  [2]
 LDCM0345  AC8 HEK-293T C137(0.90); C45(0.90)  LDD0943  [2]
 LDCM0346  AC80 HCT 116 C137(1.65)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C137(0.51)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C137(1.09)  LDD0665  [2]
 LDCM0349  AC83 PaTu 8988t C137(1.36)  LDD1228  [2]
 LDCM0350  AC84 PaTu 8988t C137(1.36)  LDD1229  [2]
 LDCM0351  AC85 PaTu 8988t C137(1.20)  LDD1230  [2]
 LDCM0352  AC86 PaTu 8988t C137(1.26)  LDD1231  [2]
 LDCM0353  AC87 PaTu 8988t C137(1.42)  LDD1232  [2]
 LDCM0354  AC88 PaTu 8988t C137(1.65)  LDD1233  [2]
 LDCM0355  AC89 PaTu 8988t C137(1.67)  LDD1234  [2]
 LDCM0357  AC90 PaTu 8988t C137(1.19)  LDD1236  [2]
 LDCM0358  AC91 PaTu 8988t C137(1.33)  LDD1237  [2]
 LDCM0359  AC92 PaTu 8988t C137(1.40)  LDD1238  [2]
 LDCM0360  AC93 PaTu 8988t C137(1.40)  LDD1239  [2]
 LDCM0361  AC94 PaTu 8988t C137(1.34)  LDD1240  [2]
 LDCM0362  AC95 PaTu 8988t C137(1.37)  LDD1241  [2]
 LDCM0363  AC96 PaTu 8988t C137(1.56)  LDD1242  [2]
 LDCM0364  AC97 PaTu 8988t C137(1.42)  LDD1243  [2]
 LDCM0365  AC98 HEK-293T C137(0.86); C45(0.83)  LDD0963  [2]
 LDCM0366  AC99 HEK-293T C137(0.83); C45(0.87)  LDD0964  [2]
 LDCM0248  AKOS034007472 HEK-293T C137(0.81); C45(0.81)  LDD0846  [2]
 LDCM0356  AKOS034007680 HEK-293T C137(1.09); C45(1.09)  LDD0954  [2]
 LDCM0275  AKOS034007705 HEK-293T C137(1.14); C45(1.14)  LDD0873  [2]
 LDCM0367  CL1 HCT 116 C45(0.93)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C45(0.73)  LDD0685  [2]
 LDCM0369  CL100 PaTu 8988t C45(0.27)  LDD1248  [2]
 LDCM0370  CL101 HEK-293T C137(0.94); C45(0.94)  LDD0968  [2]
 LDCM0371  CL102 HEK-293T C137(1.12); C45(1.12)  LDD0969  [2]
 LDCM0372  CL103 HEK-293T C137(0.92); C45(0.92)  LDD0970  [2]
 LDCM0373  CL104 HEK-293T C137(1.05); C45(1.05)  LDD0971  [2]
 LDCM0374  CL105 HCT 116 C45(0.66)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C45(0.59)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C45(0.62)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C45(0.58)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C45(0.68)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C45(0.77)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C45(0.61)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C45(0.64)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C137(0.95)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C137(0.84)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C137(0.96)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C137(0.89)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C137(0.90)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C137(1.36)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C137(0.95)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C137(1.09)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C45(0.89)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C137(0.95)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C45(0.95); C137(1.00)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C137(1.00); C45(1.03)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C45(0.90); C137(0.91)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C137(1.05); C45(1.23)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C45(0.84)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C45(0.64)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C45(0.59)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C45(0.48)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C45(0.88)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C45(1.11)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C45(0.84)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C45(0.82)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C45(0.89)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C45(0.75)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C45(0.69)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C45(1.38)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C45(0.88)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C45(0.66)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C45(0.80)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C45(0.75)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C45(0.64)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C45(0.63)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C45(0.64)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C45(0.78)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C45(0.58)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C45(0.71)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C45(1.21)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C45(0.88)  LDD0736  [2]
 LDCM0420  CL31 HEK-293T C137(0.95); C45(0.95)  LDD1018  [2]
 LDCM0421  CL32 HEK-293T C137(0.88); C45(0.88)  LDD1019  [2]
 LDCM0422  CL33 HEK-293T C137(0.91); C45(0.91)  LDD1020  [2]
 LDCM0423  CL34 HEK-293T C137(0.94); C45(0.94)  LDD1021  [2]
 LDCM0424  CL35 HEK-293T C137(0.99); C45(0.99)  LDD1022  [2]
 LDCM0425  CL36 HEK-293T C137(0.93); C45(0.93)  LDD1023  [2]
 LDCM0426  CL37 HEK-293T C137(0.85); C45(0.85)  LDD1024  [2]
 LDCM0428  CL39 HEK-293T C137(1.12); C45(1.12)  LDD1026  [2]
 LDCM0429  CL4 HCT 116 C45(0.87)  LDD0746  [2]
 LDCM0430  CL40 HEK-293T C137(0.83); C45(0.83)  LDD1028  [2]
 LDCM0431  CL41 HEK-293T C137(0.93); C45(0.93)  LDD1029  [2]
 LDCM0432  CL42 HEK-293T C137(1.17); C45(1.17)  LDD1030  [2]
 LDCM0433  CL43 HEK-293T C137(1.06); C45(1.06)  LDD1031  [2]
 LDCM0434  CL44 HEK-293T C137(0.96); C45(0.96)  LDD1032  [2]
 LDCM0435  CL45 HEK-293T C137(0.95); C45(0.95)  LDD1033  [2]
 LDCM0436  CL46 HEK-293T C137(0.83); C45(0.83)  LDD1034  [2]
 LDCM0437  CL47 HEK-293T C137(0.78); C45(0.78)  LDD1035  [2]
 LDCM0438  CL48 HEK-293T C137(0.85); C45(0.85)  LDD1036  [2]
 LDCM0439  CL49 HEK-293T C137(0.83); C45(0.83)  LDD1037  [2]
 LDCM0440  CL5 HCT 116 C45(1.08)  LDD0757  [2]
 LDCM0441  CL50 HEK-293T C137(1.05); C45(1.05)  LDD1039  [2]
 LDCM0442  CL51 HEK-293T C137(0.74); C45(0.74)  LDD1040  [2]
 LDCM0443  CL52 HEK-293T C137(0.93); C45(0.93)  LDD1041  [2]
 LDCM0444  CL53 HEK-293T C137(0.94); C45(0.94)  LDD1042  [2]
 LDCM0445  CL54 HEK-293T C137(0.86); C45(0.86)  LDD1043  [2]
 LDCM0446  CL55 HEK-293T C137(0.88); C45(0.88)  LDD1044  [2]
 LDCM0447  CL56 HEK-293T C137(0.89); C45(0.89)  LDD1045  [2]
 LDCM0448  CL57 HEK-293T C137(0.93); C45(0.93)  LDD1046  [2]
 LDCM0449  CL58 HEK-293T C137(0.92); C45(0.92)  LDD1047  [2]
 LDCM0450  CL59 HEK-293T C137(0.92); C45(0.92)  LDD1048  [2]
 LDCM0451  CL6 HCT 116 C45(1.04)  LDD0768  [2]
 LDCM0452  CL60 HEK-293T C137(0.79); C45(0.79)  LDD1050  [2]
 LDCM0453  CL61 PaTu 8988t C45(0.89)  LDD1332  [2]
 LDCM0454  CL62 PaTu 8988t C45(1.49)  LDD1333  [2]
 LDCM0455  CL63 PaTu 8988t C45(1.21)  LDD1334  [2]
 LDCM0456  CL64 PaTu 8988t C45(0.83)  LDD1335  [2]
 LDCM0457  CL65 PaTu 8988t C45(0.90)  LDD1336  [2]
 LDCM0458  CL66 PaTu 8988t C45(0.82)  LDD1337  [2]
 LDCM0459  CL67 PaTu 8988t C45(0.98)  LDD1338  [2]
 LDCM0460  CL68 PaTu 8988t C45(0.90)  LDD1339  [2]
 LDCM0461  CL69 PaTu 8988t C45(0.90)  LDD1340  [2]
 LDCM0462  CL7 HCT 116 C45(1.10)  LDD0779  [2]
 LDCM0463  CL70 PaTu 8988t C45(0.72)  LDD1342  [2]
 LDCM0464  CL71 PaTu 8988t C45(1.18)  LDD1343  [2]
 LDCM0465  CL72 PaTu 8988t C45(1.91)  LDD1344  [2]
 LDCM0466  CL73 PaTu 8988t C45(0.75)  LDD1345  [2]
 LDCM0467  CL74 PaTu 8988t C45(0.93)  LDD1346  [2]
 LDCM0469  CL76 HEK-293T C137(1.04)  LDD1672  [7]
 LDCM0470  CL77 HEK-293T C137(0.96)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C137(1.02); C45(1.15)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C137(0.83); C45(1.36)  LDD1675  [7]
 LDCM0473  CL8 HCT 116 C45(0.80)  LDD0790  [2]
 LDCM0474  CL80 HEK-293T C45(1.28)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C137(1.00)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C137(0.99); C45(1.13)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C137(0.94); C45(1.06)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C137(0.84); C45(1.28)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C137(1.19)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C137(1.09); C45(0.98)  LDD1683  [7]
 LDCM0481  CL87 HEK-293T C137(1.11)  LDD1684  [7]
 LDCM0482  CL88 HEK-293T C137(1.06)  LDD1685  [7]
 LDCM0483  CL89 HEK-293T C137(1.04)  LDD1686  [7]
 LDCM0484  CL9 HCT 116 C45(0.92)  LDD0801  [2]
 LDCM0485  CL90 HEK-293T C137(1.07); C45(0.97)  LDD1688  [7]
 LDCM0486  CL91 PaTu 8988t C45(0.38)  LDD1365  [2]
 LDCM0487  CL92 PaTu 8988t C45(0.44)  LDD1366  [2]
 LDCM0488  CL93 PaTu 8988t C45(0.27)  LDD1367  [2]
 LDCM0489  CL94 PaTu 8988t C45(0.31)  LDD1368  [2]
 LDCM0490  CL95 PaTu 8988t C45(0.33)  LDD1369  [2]
 LDCM0491  CL96 PaTu 8988t C45(0.28)  LDD1370  [2]
 LDCM0492  CL97 PaTu 8988t C45(0.27)  LDD1371  [2]
 LDCM0493  CL98 PaTu 8988t C45(0.27)  LDD1372  [2]
 LDCM0494  CL99 PaTu 8988t C45(0.27)  LDD1373  [2]
 LDCM0495  E2913 HEK-293T C137(1.26)  LDD1698  [7]
 LDCM0625  F8 Ramos C137(0.35)  LDD2187  [8]
 LDCM0572  Fragment10 Ramos C45(0.85)  LDD2189  [8]
 LDCM0573  Fragment11 Ramos C137(0.39)  LDD2190  [8]
 LDCM0574  Fragment12 Ramos C45(0.97)  LDD2191  [8]
 LDCM0575  Fragment13 Ramos C45(1.15)  LDD2192  [8]
 LDCM0579  Fragment20 Ramos C45(0.63)  LDD2194  [8]
 LDCM0580  Fragment21 Ramos C45(0.82)  LDD2195  [8]
 LDCM0582  Fragment23 Ramos C45(0.83)  LDD2196  [8]
 LDCM0586  Fragment28 Ramos C137(0.96)  LDD2198  [8]
 LDCM0588  Fragment30 Ramos C45(1.03)  LDD2199  [8]
 LDCM0590  Fragment32 Ramos C45(0.82)  LDD2201  [8]
 LDCM0468  Fragment33 PaTu 8988t C45(0.86)  LDD1347  [2]
 LDCM0566  Fragment4 Ramos C137(0.61)  LDD2184  [8]
 LDCM0427  Fragment51 HEK-293T C137(1.02); C45(1.02)  LDD1025  [2]
 LDCM0610  Fragment52 Ramos C45(1.62)  LDD2204  [8]
 LDCM0614  Fragment56 Ramos C45(1.10)  LDD2205  [8]
 LDCM0569  Fragment7 Ramos C137(0.36)  LDD2186  [8]
 LDCM0571  Fragment9 Ramos C45(0.68)  LDD2188  [8]
 LDCM0022  KB02 HEK-293T C137(0.89); C45(1.03)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C137(0.86); C45(1.04)  LDD1497  [7]
 LDCM0024  KB05 HMCB C45(3.12)  LDD3312  [9]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C45(0.67)  LDD2089  [1]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C45(1.21)  LDD2099  [1]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C45(0.68)  LDD2101  [1]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C45(0.90)  LDD2109  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cullin-1 (CUL1) Cullin family Q13616
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mediator of RNA polymerase II transcription subunit 17 (MED17) Mediator complex subunit 17 family Q9NVC6
Mediator of RNA polymerase II transcription subunit 18 (MED18) Mediator complex subunit 18 family Q9BUE0
Mediator of RNA polymerase II transcription subunit 27 (MED27) Mediator complex subunit 27 family Q6P2C8
Mediator of RNA polymerase II transcription subunit 29 (MED29) Mediator complex subunit 29 family Q9NX70

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840