Details of the Target

General Information of Target

Target ID LDTP01161
Target Name Low-density lipoprotein receptor-related protein 5 (LRP5)
Gene Name LRP5
Gene ID 4041
Synonyms
LR3; LRP7; Low-density lipoprotein receptor-related protein 5; LRP-5; Low-density lipoprotein receptor-related protein 7; LRP-7
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MEAAPPGPPWPLLLLLLLLLALCGCPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVS
GLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGK
KLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAG
MDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHP
FALTLSGDTLYWTDWQTRSIHACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTRCE
EDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKAGAEEVLLLARRTDLRRISLDTP
DFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDG
IAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGE
NPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTL
LEDKLPHIFGFTLLGDFIYWTDWQRRSIERVHKVKASRDVIIDQLPDLMGLKAVNVAKVV
GTNPCADRNGGCSHLCFFTPHATRCGCPIGLELLSDMKTCIVPEAFLVFTSRAAIHRISL
ETNNNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYP
EGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEW
GGKPRIVRAFMDGTNCMTLVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVV
IADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQ
DGLNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCSPPTTFLLFSQKSAISRMI
PDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVDGRQNIKRAKDDGTQPFVLTSLSQGQ
NPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGY
LYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCD
LSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTG
IHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCS
PDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSAAQFPCARGQCVDLRLRCDGE
ADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITKPPSDDS
PAHSSAIGPVIGIILSLFVMGGVYFVCQRVVCQRYAGANGPFPHEYVSGTPHVPLNFIAP
GGSQHGPFTGIACGKSMMSSVSLMGGRGGVPLYDRNHVTGASSSSSSSTKATLYPPILNP
PPSPATDPSLYNMDMFYSSNIPATARPYRPYIIRGMAPPTTPCSTDVCDSDYSASRWKAS
KYYLDLNSDSDPYPPPPTPHSQYLSAEDSCPPSPATERSYFHLFPPPPSPCTDSS
Target Type
Clinical trial
Target Bioclass
Other
Family
LDLR family
Subcellular location
Membrane
Function
Acts as a coreceptor with members of the frizzled family of seven-transmembrane spanning receptors to transduce signal by Wnt proteins . Activates the canonical Wnt signaling pathway that controls cell fate determination and self-renewal during embryonic development and adult tissue regeneration. In particular, may play an important role in the development of the posterior patterning of the epiblast during gastrulation. During bone development, regulates osteoblast proliferation and differentiation thus determining bone mass. Mechanistically, the formation of the signaling complex between Wnt ligand, frizzled receptor and LRP5 coreceptor promotes the recruitment of AXIN1 to LRP5, stabilizing beta-catenin/CTNNB1 and activating TCF/LEF-mediated transcriptional programs. Acts as a coreceptor for non-Wnt proteins, such as norrin/NDP. Binding of norrin/NDP to frizzled 4/FZD4-LRP5 receptor complex triggers beta-catenin/CTNNB1-dependent signaling known to be required for retinal vascular development. Plays a role in controlling postnatal vascular regression in retina via macrophage-induced endothelial cell apoptosis.
TTD ID
T86072
Uniprot ID
O75197
DrugMap ID
TT7VMG4
Ensemble ID
ENST00000294304.12
HGNC ID
HGNC:6697
ChEMBL ID
CHEMBL4295675

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C263(1.58)  LDD1702  [1]
DBIA
 Probe Info  		C1543(1.12); C1548(1.12)  LDD0078  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 PaTu 8988t C1543(1.49); C1548(1.49)  LDD1094  [2]
 LDCM0216  AC100 HCT 116 C1543(1.04); C1548(1.04)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C1543(1.75); C1548(1.75)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C1543(1.76); C1548(1.76)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C1543(1.13); C1548(1.13)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C1543(1.56); C1548(1.56)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C1543(2.25); C1548(2.25)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C1543(1.47); C1548(1.47)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C1543(1.03); C1548(1.59)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C1543(1.59); C1548(1.95)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C1543(2.44); C1548(1.09)  LDD0542  [2]
 LDCM0226  AC11 PaTu 8988t C1543(1.49); C1548(1.49)  LDD1105  [2]
 LDCM0227  AC110 HCT 116 C1543(1.79); C1548(1.40)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C1543(1.59); C1548(1.25)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C1543(0.78); C1548(1.25)  LDD0546  [2]
 LDCM0237  AC12 PaTu 8988t C1543(1.62); C1548(1.62)  LDD1116  [2]
 LDCM0246  AC128 HCT 116 C1543(1.13); C1548(1.13)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C1543(0.85); C1548(0.85)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C1543(0.87); C1548(0.87)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C1543(1.03); C1548(1.03)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C1543(0.87); C1548(0.87)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C1543(0.78); C1548(0.78)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C1543(1.19); C1548(1.19)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C1543(1.03); C1548(1.03)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C1543(1.49); C1548(1.49)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C1543(0.74); C1548(0.74)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C1543(0.69); C1548(0.69)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C1543(1.27); C1548(1.27)  LDD0575  [2]
 LDCM0259  AC14 PaTu 8988t C1543(1.32); C1548(1.32)  LDD1138  [2]
 LDCM0260  AC140 HCT 116 C1543(1.31); C1548(1.31)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C1543(1.16); C1548(1.16)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C1543(0.67); C1548(0.67)  LDD0579  [2]
 LDCM0270  AC15 PaTu 8988t C1543(1.48); C1548(1.48)  LDD1149  [2]
 LDCM0276  AC17 HCT 116 C1543(1.01); C1548(1.01)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C1543(2.60); C1548(2.60)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C1543(1.02); C1548(1.02)  LDD0595  [2]
 LDCM0280  AC20 HCT 116 C1543(1.09); C1548(1.09)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C1543(1.09); C1548(1.09)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C1543(1.06); C1548(1.06)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C1543(1.24); C1548(1.24)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C1543(1.01); C1548(1.01)  LDD0601  [2]
 LDCM0296  AC35 PaTu 8988t C1543(0.98); C1548(0.98)  LDD1175  [2]
 LDCM0297  AC36 PaTu 8988t C1543(0.83); C1548(0.83)  LDD1176  [2]
 LDCM0298  AC37 PaTu 8988t C1543(0.76); C1548(0.76)  LDD1177  [2]
 LDCM0299  AC38 PaTu 8988t C1543(0.75); C1548(0.75)  LDD1178  [2]
 LDCM0300  AC39 PaTu 8988t C1543(0.91); C1548(0.91)  LDD1179  [2]
 LDCM0302  AC40 PaTu 8988t C1543(0.93); C1548(0.93)  LDD1181  [2]
 LDCM0303  AC41 PaTu 8988t C1543(0.87); C1548(0.87)  LDD1182  [2]
 LDCM0304  AC42 PaTu 8988t C1543(0.96); C1548(0.96)  LDD1183  [2]
 LDCM0305  AC43 PaTu 8988t C1543(1.00); C1548(1.00)  LDD1184  [2]
 LDCM0306  AC44 PaTu 8988t C1543(1.08); C1548(1.08)  LDD1185  [2]
 LDCM0307  AC45 PaTu 8988t C1543(1.10); C1548(1.10)  LDD1186  [2]
 LDCM0308  AC46 PaTu 8988t C1543(0.92); C1548(0.92)  LDD1187  [2]
 LDCM0309  AC47 PaTu 8988t C1543(0.90); C1548(0.90)  LDD1188  [2]
 LDCM0310  AC48 PaTu 8988t C1543(0.85); C1548(0.85)  LDD1189  [2]
 LDCM0311  AC49 PaTu 8988t C1543(0.96); C1548(0.96)  LDD1190  [2]
 LDCM0313  AC50 PaTu 8988t C1543(1.14); C1548(1.14)  LDD1192  [2]
 LDCM0314  AC51 PaTu 8988t C1543(0.56); C1548(0.56)  LDD1193  [2]
 LDCM0315  AC52 PaTu 8988t C1543(0.92); C1548(0.92)  LDD1194  [2]
 LDCM0316  AC53 PaTu 8988t C1543(1.10); C1548(1.10)  LDD1195  [2]
 LDCM0317  AC54 PaTu 8988t C1543(1.39); C1548(1.39)  LDD1196  [2]
 LDCM0318  AC55 PaTu 8988t C1543(0.97); C1548(0.97)  LDD1197  [2]
 LDCM0319  AC56 PaTu 8988t C1543(1.12); C1548(1.12)  LDD1198  [2]
 LDCM0323  AC6 PaTu 8988t C1543(1.31); C1548(1.31)  LDD1202  [2]
 LDCM0332  AC68 PaTu 8988t C1543(1.27); C1548(1.27)  LDD1211  [2]
 LDCM0333  AC69 PaTu 8988t C1543(2.05); C1548(2.05)  LDD1212  [2]
 LDCM0334  AC7 PaTu 8988t C1543(1.09); C1548(1.09)  LDD1213  [2]
 LDCM0335  AC70 PaTu 8988t C1543(1.91); C1548(1.91)  LDD1214  [2]
 LDCM0336  AC71 PaTu 8988t C1543(1.79); C1548(1.79)  LDD1215  [2]
 LDCM0337  AC72 PaTu 8988t C1543(1.94); C1548(1.94)  LDD1216  [2]
 LDCM0338  AC73 PaTu 8988t C1543(1.48); C1548(1.48)  LDD1217  [2]
 LDCM0339  AC74 PaTu 8988t C1543(1.96); C1548(1.96)  LDD1218  [2]
 LDCM0340  AC75 PaTu 8988t C1543(1.47); C1548(1.47)  LDD1219  [2]
 LDCM0341  AC76 PaTu 8988t C1543(1.35); C1548(1.35)  LDD1220  [2]
 LDCM0342  AC77 PaTu 8988t C1543(1.37); C1548(1.37)  LDD1221  [2]
 LDCM0343  AC78 PaTu 8988t C1543(2.15); C1548(2.15)  LDD1222  [2]
 LDCM0344  AC79 PaTu 8988t C1543(1.90); C1548(1.90)  LDD1223  [2]
 LDCM0345  AC8 PaTu 8988t C1543(1.00); C1548(1.00)  LDD1224  [2]
 LDCM0346  AC80 PaTu 8988t C1543(1.87); C1548(1.87)  LDD1225  [2]
 LDCM0347  AC81 PaTu 8988t C1543(1.91); C1548(1.91)  LDD1226  [2]
 LDCM0348  AC82 PaTu 8988t C1543(1.85); C1548(1.85)  LDD1227  [2]
 LDCM0349  AC83 PaTu 8988t C1543(0.78); C1548(0.78)  LDD1228  [2]
 LDCM0350  AC84 PaTu 8988t C1543(0.88); C1548(0.88)  LDD1229  [2]
 LDCM0351  AC85 PaTu 8988t C1543(1.17); C1548(1.17)  LDD1230  [2]
 LDCM0352  AC86 PaTu 8988t C1543(1.18); C1548(1.18)  LDD1231  [2]
 LDCM0353  AC87 PaTu 8988t C1543(1.02); C1548(1.02)  LDD1232  [2]
 LDCM0354  AC88 PaTu 8988t C1543(0.99); C1548(0.99)  LDD1233  [2]
 LDCM0355  AC89 PaTu 8988t C1543(0.96); C1548(0.96)  LDD1234  [2]
 LDCM0357  AC90 PaTu 8988t C1543(1.03); C1548(1.03)  LDD1236  [2]
 LDCM0358  AC91 PaTu 8988t C1543(0.96); C1548(0.96)  LDD1237  [2]
 LDCM0359  AC92 PaTu 8988t C1543(0.95); C1548(0.95)  LDD1238  [2]
 LDCM0360  AC93 PaTu 8988t C1543(1.07); C1548(1.07)  LDD1239  [2]
 LDCM0361  AC94 PaTu 8988t C1543(0.82); C1548(0.82)  LDD1240  [2]
 LDCM0362  AC95 PaTu 8988t C1543(1.14); C1548(1.14)  LDD1241  [2]
 LDCM0363  AC96 PaTu 8988t C1543(1.00); C1548(1.00)  LDD1242  [2]
 LDCM0364  AC97 PaTu 8988t C1543(0.96); C1548(0.96)  LDD1243  [2]
 LDCM0365  AC98 HCT 116 C1543(1.67); C1548(1.67)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C1543(1.19); C1548(1.19)  LDD0683  [2]
 LDCM0248  AKOS034007472 PaTu 8988t C1543(1.44); C1548(1.44)  LDD1127  [2]
 LDCM0356  AKOS034007680 PaTu 8988t C1543(1.33); C1548(1.33)  LDD1235  [2]
 LDCM0275  AKOS034007705 PaTu 8988t C1543(1.49); C1548(1.49)  LDD1154  [2]
 LDCM0020  ARS-1620 HCC44 C1543(1.12); C1548(1.12)  LDD0078  [2]
 LDCM0370  CL101 PaTu 8988t C1543(1.27); C1548(1.27)  LDD1249  [2]
 LDCM0371  CL102 PaTu 8988t C1543(1.50); C1548(1.50)  LDD1250  [2]
 LDCM0372  CL103 PaTu 8988t C1543(1.52); C1548(1.52)  LDD1251  [2]
 LDCM0373  CL104 PaTu 8988t C1543(1.63); C1548(1.63)  LDD1252  [2]
 LDCM0374  CL105 HCT 116 C1543(1.74); C1548(1.74)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C1543(1.62); C1548(1.62)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C1543(1.26); C1548(1.26)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C1543(1.31); C1548(1.31)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C1543(1.21); C1548(1.21)  LDD0695  [2]
 LDCM0380  CL110 HCT 116 C1543(2.21); C1548(2.21)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C1543(1.36); C1548(1.36)  LDD0698  [2]
 LDCM0387  CL117 PaTu 8988t C1543(0.83); C1548(0.83)  LDD1266  [2]
 LDCM0388  CL118 PaTu 8988t C1543(0.89); C1548(0.89)  LDD1267  [2]
 LDCM0389  CL119 PaTu 8988t C1543(0.98); C1548(0.98)  LDD1268  [2]
 LDCM0391  CL120 PaTu 8988t C1543(1.05); C1548(1.05)  LDD1270  [2]
 LDCM0392  CL121 PaTu 8988t C1543(0.95); C1548(0.95)  LDD1271  [2]
 LDCM0393  CL122 PaTu 8988t C1543(0.97); C1548(0.97)  LDD1272  [2]
 LDCM0394  CL123 PaTu 8988t C1543(1.31); C1548(1.31)  LDD1273  [2]
 LDCM0395  CL124 PaTu 8988t C1543(1.19); C1548(1.19)  LDD1274  [2]
 LDCM0403  CL16 HCT 116 C1543(0.72); C1548(0.72)  LDD0720  [2]
 LDCM0404  CL17 PaTu 8988t C1543(0.52); C1548(0.52)  LDD1283  [2]
 LDCM0405  CL18 PaTu 8988t C1543(0.50); C1548(0.50)  LDD1284  [2]
 LDCM0406  CL19 PaTu 8988t C1543(0.37); C1548(0.37)  LDD1285  [2]
 LDCM0408  CL20 PaTu 8988t C1543(0.32); C1548(0.32)  LDD1287  [2]
 LDCM0409  CL21 PaTu 8988t C1543(0.58); C1548(0.58)  LDD1288  [2]
 LDCM0410  CL22 PaTu 8988t C1543(0.62); C1548(0.62)  LDD1289  [2]
 LDCM0411  CL23 PaTu 8988t C1543(0.52); C1548(0.52)  LDD1290  [2]
 LDCM0412  CL24 PaTu 8988t C1543(0.43); C1548(0.43)  LDD1291  [2]
 LDCM0413  CL25 PaTu 8988t C1543(0.58); C1548(0.58)  LDD1292  [2]
 LDCM0414  CL26 PaTu 8988t C1543(0.37); C1548(0.37)  LDD1293  [2]
 LDCM0415  CL27 PaTu 8988t C1543(0.48); C1548(0.48)  LDD1294  [2]
 LDCM0416  CL28 PaTu 8988t C1543(0.49); C1548(0.49)  LDD1295  [2]
 LDCM0417  CL29 PaTu 8988t C1543(0.52); C1548(0.52)  LDD1296  [2]
 LDCM0419  CL30 PaTu 8988t C1543(0.52); C1548(0.52)  LDD1298  [2]
 LDCM0420  CL31 PaTu 8988t C1543(1.69); C1548(1.69)  LDD1299  [2]
 LDCM0421  CL32 HCT 116 C1543(0.64); C1548(0.64)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C1543(1.23); C1548(1.23)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C1543(0.68); C1548(0.68)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C1543(0.81); C1548(0.81)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C1543(0.78); C1548(0.78)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C1543(0.65); C1548(0.65)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C1543(0.91); C1548(0.91)  LDD0745  [2]
 LDCM0430  CL40 HCT 116 C1543(0.88); C1548(0.88)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C1543(0.57); C1548(0.57)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C1543(0.75); C1548(0.75)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C1543(0.99); C1548(0.99)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C1543(0.88); C1548(0.88)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C1543(0.77); C1548(0.77)  LDD0752  [2]
 LDCM0436  CL46 PaTu 8988t C1543(1.18); C1548(1.18)  LDD1315  [2]
 LDCM0437  CL47 PaTu 8988t C1543(1.27); C1548(1.27)  LDD1316  [2]
 LDCM0438  CL48 PaTu 8988t C1543(1.28); C1548(1.28)  LDD1317  [2]
 LDCM0439  CL49 PaTu 8988t C1543(1.21); C1548(1.21)  LDD1318  [2]
 LDCM0441  CL50 PaTu 8988t C1543(1.56); C1548(1.56)  LDD1320  [2]
 LDCM0442  CL51 PaTu 8988t C1543(1.58); C1548(1.58)  LDD1321  [2]
 LDCM0443  CL52 PaTu 8988t C1543(1.33); C1548(1.33)  LDD1322  [2]
 LDCM0444  CL53 PaTu 8988t C1543(1.68); C1548(1.68)  LDD1323  [2]
 LDCM0445  CL54 PaTu 8988t C1543(1.31); C1548(1.31)  LDD1324  [2]
 LDCM0446  CL55 PaTu 8988t C1543(1.17); C1548(1.17)  LDD1325  [2]
 LDCM0447  CL56 PaTu 8988t C1543(1.55); C1548(1.55)  LDD1326  [2]
 LDCM0448  CL57 PaTu 8988t C1543(1.30); C1548(1.30)  LDD1327  [2]
 LDCM0449  CL58 PaTu 8988t C1543(1.15); C1548(1.15)  LDD1328  [2]
 LDCM0450  CL59 PaTu 8988t C1543(1.17); C1548(1.17)  LDD1329  [2]
 LDCM0452  CL60 PaTu 8988t C1543(1.34); C1548(1.34)  LDD1331  [2]
 LDCM0453  CL61 HCT 116 C1543(1.35); C1548(1.35)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C1543(1.09); C1548(1.09)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C1543(1.70); C1548(1.70)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C1543(1.66); C1548(1.66)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C1543(0.99); C1548(0.99)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C1543(1.09); C1548(1.09)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C1543(1.59); C1548(1.59)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C1543(1.65); C1548(1.65)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C1543(1.17); C1548(1.17)  LDD0778  [2]
 LDCM0463  CL70 HCT 116 C1543(1.34); C1548(1.34)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C1543(1.96); C1548(1.96)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C1543(0.86); C1548(0.86)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C1543(1.25); C1548(1.25)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C1543(1.39); C1548(1.39)  LDD0784  [2]
 LDCM0469  CL76 PaTu 8988t C1543(1.03); C1548(1.03)  LDD1348  [2]
 LDCM0470  CL77 PaTu 8988t C1543(1.07); C1548(1.07)  LDD1349  [2]
 LDCM0471  CL78 PaTu 8988t C1543(1.05); C1548(1.05)  LDD1350  [2]
 LDCM0472  CL79 PaTu 8988t C1543(1.06); C1548(1.06)  LDD1351  [2]
 LDCM0474  CL80 PaTu 8988t C1543(1.15); C1548(1.15)  LDD1353  [2]
 LDCM0475  CL81 PaTu 8988t C1543(1.41); C1548(1.41)  LDD1354  [2]
 LDCM0476  CL82 PaTu 8988t C1543(1.36); C1548(1.36)  LDD1355  [2]
 LDCM0477  CL83 PaTu 8988t C1543(1.58); C1548(1.58)  LDD1356  [2]
 LDCM0478  CL84 PaTu 8988t C1543(1.26); C1548(1.26)  LDD1357  [2]
 LDCM0479  CL85 PaTu 8988t C1543(0.93); C1548(0.93)  LDD1358  [2]
 LDCM0480  CL86 PaTu 8988t C1543(1.20); C1548(1.20)  LDD1359  [2]
 LDCM0481  CL87 PaTu 8988t C1543(1.44); C1548(1.44)  LDD1360  [2]
 LDCM0482  CL88 PaTu 8988t C1543(1.37); C1548(1.37)  LDD1361  [2]
 LDCM0483  CL89 PaTu 8988t C1543(1.20); C1548(1.20)  LDD1362  [2]
 LDCM0485  CL90 PaTu 8988t C1543(1.37); C1548(1.37)  LDD1364  [2]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C263(1.58)  LDD1702  [1]
 LDCM0468  Fragment33 HCT 116 C1543(0.90); C1548(0.90)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C1543(0.67); C1548(0.67)  LDD0744  [2]
 LDCM0022  KB02 A2780 C1310(1.84)  LDD2254  [4]
 LDCM0023  KB03 ICC20 C1310(2.70)  LDD2804  [4]
 LDCM0024  KB05 COLO792 C605(2.16)  LDD3310  [4]
 LDCM0021  THZ1 HCT 116 C1543(0.89); C1548(0.89)  LDD2173  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein APCDD1 (APCDD1) APCDD1 family Q8J025
Caprin-2 (CAPRIN2) Caprin family Q6IMN6
Sclerostin (SOST) Sclerostin family Q9BQB4

The Drug(s) Related To This Target

Phase 1
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Bi 905677 Antibody DTB43H
Bi 905681 Antibody D9DQ1I

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840