Details of the Target

General Information of Target

Target ID LDTP00889
Target Name Probable phospholipid-transporting ATPase IIB (ATP9B)
Gene Name ATP9B
Gene ID 374868
Synonyms
ATPIIB; NEO1L; Probable phospholipid-transporting ATPase IIB; EC 7.6.2.1; ATPase class II type 9B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MADQIPLYPVRSAAAAAANRKRAAYYSAAGPRPGADRHSRYQLEDESAHLDEMPLMMSEE
GFENEESDYHTLPRARIMQRKRGLEWFVCDGWKFLCTSCCGWLINICRRKKELKARTVWL
GCPEKCEEKHPRNSIKNQKYNVFTFIPGVLYEQFKFFLNLYFLVISCSQFVPALKIGYLY
TYWAPLGFVLAVTMTREAIDEFRRFQRDKEVNSQLYSKLTVRGKVQVKSSDIQVGDLIIV
EKNQRIPSDMVFLRTSEKAGSCFIRTDQLDGETDWKLKVAVSCTQQLPALGDLFSISAYV
YAQKPQMDIHSFEGTFTREDSDPPIHESLSIENTLWASTIVASGTVIGVVIYTGKETRSV
MNTSNPKNKVGLLDLELNRLTKALFLALVALSIVMVTLQGFVGPWYRNLFRFLLLFSYII
PISLRVNLDMGKAVYGWMMMKDENIPGTVVRTSTIPEELGRLVYLLTDKTGTLTQNEMIF
KRLHLGTVSYGADTMDEIQSHVRDSYSQMQSQAGGNNTGSTPLRKAQSSAPKVRKSVSSR
IHEAVKAIVLCHNVTPVYESRAGVTEETEFAEADQDFSDENRTYQASSPDEVALVQWTES
VGLTLVSRDLTSMQLKTPSGQVLSFCILQLFPFTSESKRMGVIVRDESTAEITFYMKGAD
VAMSPIVQYNDWLEEECGNMAREGLRTLVVAKKALTEEQYQDFESRYTQAKLSMHDRSLK
VAAVVESLEREMELLCLTGVEDQLQADVRPTLEMLRNAGIKIWMLTGDKLETATCIAKSS
HLVSRTQDIHIFRQVTSRGEAHLELNAFRRKHDCALVISGDSLEVCLKYYEHEFVELACQ
CPAVVCCRCSPTQKARIVTLLQQHTGRRTCAIGDGGNDVSMIQAADCGIGIEGKEGKQAS
LAADFSITQFRHIGRLLMVHGRNSYKRSAALGQFVMHRGLIISTMQAVFSSVFYFASVPL
YQGFLMVGYATIYTMFPVFSLVLDQDVKPEMAMLYPELYKDLTKGRSLSFKTFLIWVLIS
IYQGGILMYGALVLFESEFVHVVAISFTALILTELLMVALTVRTWHWLMVVAEFLSLGCY
VSSLAFLNEYFGIGRVSFGAFLDVAFITTVTFLWKVSAITVVSCLPLYVLKYLRRKLSPP
SYCKLAS
Target Bioclass
Enzyme
Family
Cation transport ATPase (P-type) (TC 3.A.3) family, Type IV subfamily
Subcellular location
Golgi apparatus, trans-Golgi network membrane
Uniprot ID
O43861
Ensemble ID
ENST00000307671.12
HGNC ID
HGNC:13541

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.P842L DBIA    Probe Info 
AU565 SNV: p.E675Q DBIA    Probe Info 
BT549 SNV: p.E210Ter .
HCT15 SNV: p.C100Y .
IM95 SNV: p.R868H DBIA    Probe Info 
KMCH1 SNV: p.H542P DBIA    Probe Info 
KMRC20 Substitution: p.E683P DBIA    Probe Info 
MCAS SNV: p.T452I .
MOLT4 SNV: p.P288S .
NALM6 SNV: p.R116H .
NCIH2291 SNV: p.R37W DBIA    Probe Info 
SAOS2 SNV: p.P9R .
SNGM SNV: p.H832Y DBIA    Probe Info 
TE11 Insertion: p.R682delinsPYGG DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K1004(10.00)  LDD0277  [1]
DBIA
 Probe Info  		C122(11.63)  LDD0209  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C870(0.87); C887(0.87)  LDD0531  [4]
 LDCM0215  AC10 HEK-293T C775(0.98); C122(0.99)  LDD1508  [5]
 LDCM0226  AC11 HEK-293T C775(0.96); C122(1.04)  LDD1509  [5]
 LDCM0237  AC12 HEK-293T C775(0.98); C122(1.03)  LDD1510  [5]
 LDCM0259  AC14 HEK-293T C122(1.01)  LDD1512  [5]
 LDCM0270  AC15 HEK-293T C551(1.01); C775(1.03); C122(1.02)  LDD1513  [5]
 LDCM0276  AC17 HEK-293T C551(1.01); C775(1.21)  LDD1515  [5]
 LDCM0277  AC18 HEK-293T C775(0.91); C122(0.98)  LDD1516  [5]
 LDCM0278  AC19 HEK-293T C775(1.08); C122(1.03)  LDD1517  [5]
 LDCM0279  AC2 HCT 116 C870(0.97); C887(0.97)  LDD0596  [4]
 LDCM0280  AC20 HEK-293T C775(0.88); C122(0.94)  LDD1519  [5]
 LDCM0281  AC21 HEK-293T C775(0.98); C122(1.03)  LDD1520  [5]
 LDCM0282  AC22 HEK-293T C122(1.02)  LDD1521  [5]
 LDCM0283  AC23 HEK-293T C551(0.91); C775(1.03); C122(0.93)  LDD1522  [5]
 LDCM0284  AC24 HEK-293T C775(0.99); C122(1.02)  LDD1523  [5]
 LDCM0285  AC25 HCT 116 C870(0.64); C887(0.64)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C870(0.51); C887(0.51)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C870(0.59); C887(0.59)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C870(0.58); C887(0.58)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C870(0.52); C887(0.52)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C870(0.98); C887(0.98)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C870(0.51); C887(0.51)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C870(0.50); C887(0.50)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C870(0.47); C887(0.47)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C870(0.64); C887(0.64)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C870(0.53); C887(0.53)  LDD0612  [4]
 LDCM0296  AC35 HEK-293T C775(1.01); C122(1.07)  LDD1535  [5]
 LDCM0297  AC36 HEK-293T C775(0.86); C122(0.96)  LDD1536  [5]
 LDCM0298  AC37 HEK-293T C775(0.97); C122(1.05)  LDD1537  [5]
 LDCM0299  AC38 HEK-293T C122(1.09)  LDD1538  [5]
 LDCM0300  AC39 HEK-293T C551(1.01); C775(1.01); C122(1.08)  LDD1539  [5]
 LDCM0301  AC4 HCT 116 C870(0.74); C887(0.74)  LDD0618  [4]
 LDCM0302  AC40 HEK-293T C775(1.05); C122(0.99)  LDD1541  [5]
 LDCM0303  AC41 HEK-293T C551(1.02); C775(1.03)  LDD1542  [5]
 LDCM0304  AC42 HEK-293T C775(0.82); C122(0.96)  LDD1543  [5]
 LDCM0305  AC43 HEK-293T C775(1.03); C122(1.03)  LDD1544  [5]
 LDCM0306  AC44 HEK-293T C775(1.16); C122(1.00)  LDD1545  [5]
 LDCM0307  AC45 HEK-293T C775(0.98); C122(0.98)  LDD1546  [5]
 LDCM0308  AC46 HEK-293T C122(1.05)  LDD1547  [5]
 LDCM0309  AC47 HEK-293T C551(1.00); C775(1.17); C122(1.02)  LDD1548  [5]
 LDCM0310  AC48 HEK-293T C775(0.96); C122(0.96)  LDD1549  [5]
 LDCM0311  AC49 HEK-293T C551(0.98); C775(1.25)  LDD1550  [5]
 LDCM0312  AC5 HCT 116 C870(0.85); C887(0.85)  LDD0629  [4]
 LDCM0313  AC50 HEK-293T C775(0.85); C122(1.03)  LDD1552  [5]
 LDCM0314  AC51 HEK-293T C775(0.96); C122(1.07)  LDD1553  [5]
 LDCM0315  AC52 HEK-293T C775(0.97); C122(1.05)  LDD1554  [5]
 LDCM0316  AC53 HEK-293T C775(0.98); C122(0.98)  LDD1555  [5]
 LDCM0317  AC54 HEK-293T C122(1.03)  LDD1556  [5]
 LDCM0318  AC55 HEK-293T C551(0.95); C775(0.93); C122(1.13)  LDD1557  [5]
 LDCM0319  AC56 HEK-293T C775(1.03); C122(1.00)  LDD1558  [5]
 LDCM0320  AC57 HEK-293T C551(0.96); C775(1.13)  LDD1559  [5]
 LDCM0321  AC58 HEK-293T C775(0.91); C122(0.98)  LDD1560  [5]
 LDCM0322  AC59 HEK-293T C775(1.02); C122(1.08)  LDD1561  [5]
 LDCM0323  AC6 HEK-293T C122(1.04)  LDD1562  [5]
 LDCM0324  AC60 HEK-293T C775(0.97); C122(1.01)  LDD1563  [5]
 LDCM0325  AC61 HEK-293T C775(1.00); C122(1.02)  LDD1564  [5]
 LDCM0326  AC62 HEK-293T C122(1.04)  LDD1565  [5]
 LDCM0327  AC63 HEK-293T C551(1.07); C775(1.06); C122(1.06)  LDD1566  [5]
 LDCM0328  AC64 HEK-293T C775(1.07); C122(1.01)  LDD1567  [5]
 LDCM0334  AC7 HEK-293T C551(0.92); C775(1.08); C122(1.06)  LDD1568  [5]
 LDCM0345  AC8 HEK-293T C775(1.04); C122(0.98)  LDD1569  [5]
 LDCM0349  AC83 HCT 116 C870(0.77); C887(0.77)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C870(0.63); C887(0.63)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C870(0.38); C887(0.38)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C870(0.54); C887(0.54)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C870(1.40); C887(1.40)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C870(0.88); C887(0.88)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C870(0.53); C887(0.53)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C870(0.81); C887(0.81)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C870(0.68); C887(0.68)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C870(0.60); C887(0.60)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C870(0.42); C887(0.42)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C870(0.68); C887(0.68)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C870(0.81); C887(0.81)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C870(0.67); C887(0.67)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C870(0.47); C887(0.47)  LDD0681  [4]
 LDCM0248  AKOS034007472 HEK-293T C775(1.00); C122(1.08)  LDD1511  [5]
 LDCM0356  AKOS034007680 HEK-293T C551(1.00); C775(1.07)  LDD1570  [5]
 LDCM0275  AKOS034007705 HEK-293T C775(1.00); C122(0.96)  LDD1514  [5]
 LDCM0367  CL1 HCT 116 C870(0.99); C887(0.99)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C870(0.93); C887(0.93)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C870(0.99); C887(0.99)  LDD0686  [4]
 LDCM0371  CL102 HEK-293T C1143(1.29); C551(1.14); C775(1.08); C122(0.99)  LDD1575  [5]
 LDCM0372  CL103 HEK-293T C122(1.04)  LDD1576  [5]
 LDCM0373  CL104 HEK-293T C775(1.18); C122(1.01)  LDD1577  [5]
 LDCM0375  CL106 HEK-293T C1143(1.02); C551(1.02); C775(1.00); C122(0.97)  LDD1579  [5]
 LDCM0376  CL107 HEK-293T C122(1.03)  LDD1580  [5]
 LDCM0377  CL108 HEK-293T C775(0.93); C122(0.99)  LDD1581  [5]
 LDCM0379  CL11 HCT 116 C870(0.90); C887(0.90)  LDD0696  [4]
 LDCM0380  CL110 HEK-293T C1143(1.08); C551(0.96); C775(1.12); C122(1.06)  LDD1584  [5]
 LDCM0381  CL111 HEK-293T C122(1.01)  LDD1585  [5]
 LDCM0382  CL112 HCT 116 C870(0.72); C887(0.72)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C870(0.51); C887(0.51)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C870(0.56); C887(0.56)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C870(0.57); C887(0.57)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C870(0.53); C887(0.53)  LDD0703  [4]
 LDCM0388  CL118 HEK-293T C1143(1.00); C551(1.13); C775(1.04); C122(1.10)  LDD1592  [5]
 LDCM0389  CL119 HEK-293T C122(1.01)  LDD1593  [5]
 LDCM0390  CL12 HCT 116 C870(1.27); C887(1.27)  LDD0707  [4]
 LDCM0391  CL120 HEK-293T C775(1.06); C122(1.02)  LDD1595  [5]
 LDCM0393  CL122 HEK-293T C1143(0.88); C551(1.14); C775(1.04); C122(1.05)  LDD1597  [5]
 LDCM0394  CL123 HEK-293T C122(1.07)  LDD1598  [5]
 LDCM0395  CL124 HEK-293T C775(1.07); C122(0.95)  LDD1599  [5]
 LDCM0397  CL126 HEK-293T C1143(0.98); C551(1.10); C775(0.94); C122(0.95)  LDD1601  [5]
 LDCM0398  CL127 HEK-293T C122(1.02)  LDD1602  [5]
 LDCM0399  CL128 HEK-293T C775(1.03); C122(0.99)  LDD1603  [5]
 LDCM0400  CL13 HCT 116 C870(0.89); C887(0.89)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C870(0.96); C887(0.96)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C870(0.67); C887(0.67)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C870(0.93); C887(0.93)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C870(0.82); C887(0.82)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C870(0.81); C887(0.81)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C870(0.78); C887(0.78)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C870(0.83); C887(0.83)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C870(0.83); C887(0.83)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C870(0.91); C887(0.91)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C870(1.15); C887(1.15)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C870(0.80); C887(0.80)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C870(0.91); C887(0.91)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C870(0.82); C887(0.82)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C870(0.86); C887(0.86)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C870(0.89); C887(0.89)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C870(0.92); C887(0.92)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C870(0.89); C887(0.89)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C870(0.80); C887(0.80)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C870(0.88); C887(0.88)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C870(0.65); C887(0.65)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C870(0.47); C887(0.47)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C870(0.46); C887(0.46)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C870(0.83); C887(0.83)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C870(0.50); C887(0.50)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C870(0.69); C887(0.69)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C870(0.74); C887(0.74)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C870(0.67); C887(0.67)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C870(1.14); C887(1.14)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C870(0.85); C887(0.85)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C870(0.87); C887(0.87)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C870(0.81); C887(0.81)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C870(0.57); C887(0.57)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C870(0.62); C887(0.62)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C870(0.67); C887(0.67)  LDD0752  [4]
 LDCM0436  CL46 HEK-293T C122(1.18)  LDD1640  [5]
 LDCM0437  CL47 HEK-293T C551(1.06); C775(1.43); C122(1.24)  LDD1641  [5]
 LDCM0438  CL48 HEK-293T C775(1.45); C122(1.12)  LDD1642  [5]
 LDCM0440  CL5 HCT 116 C870(0.92); C887(0.92)  LDD0757  [4]
 LDCM0441  CL50 HEK-293T C1143(1.02); C551(1.18); C775(1.06); C122(1.06)  LDD1645  [5]
 LDCM0443  CL52 HEK-293T C775(0.99); C122(1.04)  LDD1646  [5]
 LDCM0444  CL53 HEK-293T C551(1.01); C775(1.41)  LDD1647  [5]
 LDCM0445  CL54 HEK-293T C775(1.19); C122(1.03)  LDD1648  [5]
 LDCM0446  CL55 HEK-293T C775(1.14); C122(1.13)  LDD1649  [5]
 LDCM0447  CL56 HEK-293T C775(1.09); C122(1.10)  LDD1650  [5]
 LDCM0448  CL57 HEK-293T C775(1.32); C122(1.08)  LDD1651  [5]
 LDCM0449  CL58 HEK-293T C122(1.18)  LDD1652  [5]
 LDCM0450  CL59 HEK-293T C551(1.18); C775(1.75); C122(1.20)  LDD1653  [5]
 LDCM0451  CL6 HCT 116 C870(0.93); C887(0.93)  LDD0768  [4]
 LDCM0452  CL60 HEK-293T C775(1.32); C122(1.10)  LDD1655  [5]
 LDCM0453  CL61 HCT 116 C870(0.86); C887(0.86)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C870(1.11); C887(1.11)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C870(0.72); C887(0.72)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C870(0.84); C887(0.84)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C870(1.26); C887(1.26)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C870(0.87); C887(0.87)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C870(0.75); C887(0.75)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C870(1.10); C887(1.10)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C870(1.04); C887(1.04)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C870(1.05); C887(1.05)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C870(0.73); C887(0.73)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C870(0.83); C887(0.83)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C870(1.09); C887(1.09)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C870(0.91); C887(0.91)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C870(0.87); C887(0.87)  LDD0784  [4]
 LDCM0469  CL76 HEK-293T C775(0.98); C122(1.03)  LDD1672  [5]
 LDCM0470  CL77 HEK-293T C551(1.02); C775(1.40)  LDD1673  [5]
 LDCM0471  CL78 HEK-293T C775(0.98); C122(1.05)  LDD1674  [5]
 LDCM0472  CL79 HEK-293T C775(1.05); C122(1.11)  LDD1675  [5]
 LDCM0473  CL8 HCT 116 C870(0.84); C887(0.84)  LDD0790  [4]
 LDCM0474  CL80 HEK-293T C775(1.00); C122(1.12)  LDD1677  [5]
 LDCM0475  CL81 HEK-293T C775(1.12); C122(1.10)  LDD1678  [5]
 LDCM0476  CL82 HEK-293T C122(1.21)  LDD1679  [5]
 LDCM0477  CL83 HEK-293T C551(1.03); C775(1.31); C122(1.06)  LDD1680  [5]
 LDCM0478  CL84 HEK-293T C775(0.84); C122(1.04)  LDD1681  [5]
 LDCM0480  CL86 HEK-293T C1143(0.93); C551(1.11); C775(1.13); C122(0.90)  LDD1683  [5]
 LDCM0481  CL87 HEK-293T C122(1.06)  LDD1684  [5]
 LDCM0482  CL88 HEK-293T C775(0.98); C122(0.98)  LDD1685  [5]
 LDCM0483  CL89 HEK-293T C551(1.01); C775(1.30)  LDD1686  [5]
 LDCM0484  CL9 HCT 116 C870(1.02); C887(1.02)  LDD0801  [4]
 LDCM0485  CL90 HEK-293T C775(0.90); C122(0.93)  LDD1688  [5]
 LDCM0486  CL91 HCT 116 C870(0.88); C887(0.88)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C870(0.88); C887(0.88)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C870(0.84); C887(0.84)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C870(0.90); C887(0.90)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C870(0.81); C887(0.81)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C870(0.82); C887(0.82)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C870(1.07); C887(1.07)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C870(0.88); C887(0.88)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C870(0.93); C887(0.93)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C122(1.01)  LDD1698  [5]
 LDCM0468  Fragment33 HCT 116 C870(1.03); C887(1.03)  LDD0785  [4]
 LDCM0427  Fragment51 HCT 116 C870(0.89); C887(0.89)  LDD0744  [4]
 LDCM0022  KB02 HEK-293T C551(1.06)  LDD1492  [5]
 LDCM0023  KB03 Jurkat C122(11.63)  LDD0209  [2]
 LDCM0024  KB05 HMCB C122(1.94)  LDD3312  [6]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840