Details of the Target

General Information of Target

Target ID LDTP00833
Target Name NADH dehydrogenase 1 alpha subcomplex subunit 2 (NDUFA2)
Gene Name NDUFA2
Gene ID 4695
Synonyms
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2; Complex I-B8; CI-B8; NADH-ubiquinone oxidoreductase B8 subunit
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAAAAASRGVGAKLGLREIRIHLCQRSPGSQGVRDFIEKRYVELKKANPDLPILIRECSD
VQPKLWARYAFGQETNVPLNNFSADQVTRALENVLSGKA
Target Bioclass
Enzyme
Family
Complex I NDUFA2 subunit family
Subcellular location
Mitochondrion inner membrane
Function
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Uniprot ID
O43678
Ensemble ID
ENST00000252102.9
HGNC ID
HGNC:7685
ChEMBL ID
CHEMBL2363065

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1 SNV: p.T88S .
HEC1B SNV: p.T88S IA-alkyne    Probe Info 
HT115 SNV: p.T88I .
NCIH358 SNV: p.R8P DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K13(6.25)  LDD0277  [1]
Probe 1
 Probe Info  		Y41(31.02)  LDD3495  [2]
BTD
 Probe Info  		C24(0.53)  LDD2109  [3]
Acrolein
 Probe Info  		N.A.  LDD0222  [4]
DBIA
 Probe Info  		C58(0.83)  LDD0531  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [6]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [7]
WYneO
 Probe Info  		N.A.  LDD0022  [8]
IPM
 Probe Info  		N.A.  LDD0005  [8]
TFBX
 Probe Info  		N.A.  LDD0148  [7]
Phosphinate-6
 Probe Info  		C24(0.00); C58(0.00)  LDD0018  [9]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [4]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [4]
Methacrolein
 Probe Info  		N.A.  LDD0218  [4]
AOyne
 Probe Info  		13.00  LDD0443  [10]
NAIA_5
 Probe Info  		N.A.  LDD2223  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C58(0.83)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C58(1.26)  LDD0532  [5]
 LDCM0226  AC11 HCT 116 C58(1.19)  LDD0543  [5]
 LDCM0237  AC12 HCT 116 C58(1.00)  LDD0554  [5]
 LDCM0246  AC128 PaTu 8988t C58(0.89)  LDD1125  [5]
 LDCM0247  AC129 PaTu 8988t C58(0.74)  LDD1126  [5]
 LDCM0249  AC130 PaTu 8988t C58(0.75)  LDD1128  [5]
 LDCM0250  AC131 PaTu 8988t C58(0.80)  LDD1129  [5]
 LDCM0251  AC132 PaTu 8988t C58(0.85)  LDD1130  [5]
 LDCM0252  AC133 PaTu 8988t C58(0.58)  LDD1131  [5]
 LDCM0253  AC134 PaTu 8988t C58(0.54)  LDD1132  [5]
 LDCM0254  AC135 PaTu 8988t C58(0.58)  LDD1133  [5]
 LDCM0255  AC136 PaTu 8988t C58(0.67)  LDD1134  [5]
 LDCM0256  AC137 PaTu 8988t C58(0.58)  LDD1135  [5]
 LDCM0257  AC138 PaTu 8988t C58(0.84)  LDD1136  [5]
 LDCM0258  AC139 PaTu 8988t C58(0.76)  LDD1137  [5]
 LDCM0259  AC14 HCT 116 C58(1.15)  LDD0576  [5]
 LDCM0260  AC140 PaTu 8988t C58(0.99)  LDD1139  [5]
 LDCM0261  AC141 PaTu 8988t C58(0.78)  LDD1140  [5]
 LDCM0262  AC142 PaTu 8988t C58(0.76)  LDD1141  [5]
 LDCM0263  AC143 PaTu 8988t C58(1.20)  LDD1142  [5]
 LDCM0264  AC144 PaTu 8988t C58(0.78)  LDD1143  [5]
 LDCM0265  AC145 PaTu 8988t C58(0.83)  LDD1144  [5]
 LDCM0266  AC146 PaTu 8988t C58(0.99)  LDD1145  [5]
 LDCM0267  AC147 PaTu 8988t C58(1.13)  LDD1146  [5]
 LDCM0268  AC148 PaTu 8988t C58(0.91)  LDD1147  [5]
 LDCM0269  AC149 PaTu 8988t C58(0.79)  LDD1148  [5]
 LDCM0270  AC15 HCT 116 C58(1.13)  LDD0587  [5]
 LDCM0271  AC150 PaTu 8988t C58(1.10)  LDD1150  [5]
 LDCM0272  AC151 PaTu 8988t C58(0.76)  LDD1151  [5]
 LDCM0273  AC152 PaTu 8988t C58(0.88)  LDD1152  [5]
 LDCM0274  AC153 PaTu 8988t C58(0.76)  LDD1153  [5]
 LDCM0621  AC154 PaTu 8988t C58(1.29)  LDD2166  [5]
 LDCM0622  AC155 PaTu 8988t C58(1.74)  LDD2167  [5]
 LDCM0623  AC156 PaTu 8988t C58(0.72)  LDD2168  [5]
 LDCM0624  AC157 PaTu 8988t C58(1.05)  LDD2169  [5]
 LDCM0276  AC17 HCT 116 C58(0.76)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C58(0.66)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C58(0.76)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C58(0.91)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C58(0.81)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C58(0.73)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C58(0.81)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C58(0.75)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C58(0.99)  LDD0601  [5]
 LDCM0285  AC25 PaTu 8988t C58(1.15)  LDD1164  [5]
 LDCM0286  AC26 PaTu 8988t C58(1.17)  LDD1165  [5]
 LDCM0287  AC27 PaTu 8988t C58(1.28)  LDD1166  [5]
 LDCM0288  AC28 PaTu 8988t C58(1.35)  LDD1167  [5]
 LDCM0289  AC29 PaTu 8988t C58(1.23)  LDD1168  [5]
 LDCM0290  AC3 HCT 116 C58(0.69)  LDD0607  [5]
 LDCM0291  AC30 PaTu 8988t C58(1.15)  LDD1170  [5]
 LDCM0292  AC31 PaTu 8988t C58(1.21)  LDD1171  [5]
 LDCM0293  AC32 PaTu 8988t C58(1.16)  LDD1172  [5]
 LDCM0294  AC33 PaTu 8988t C58(1.19)  LDD1173  [5]
 LDCM0295  AC34 PaTu 8988t C58(1.10)  LDD1174  [5]
 LDCM0296  AC35 HEK-293T C58(0.98)  LDD1535  [12]
 LDCM0297  AC36 HEK-293T C58(0.95)  LDD1536  [12]
 LDCM0298  AC37 HEK-293T C58(0.93)  LDD1537  [12]
 LDCM0299  AC38 HEK-293T C58(0.90)  LDD1538  [12]
 LDCM0300  AC39 HEK-293T C58(0.98)  LDD1539  [12]
 LDCM0301  AC4 HCT 116 C58(0.92)  LDD0618  [5]
 LDCM0302  AC40 HEK-293T C58(0.92)  LDD1541  [12]
 LDCM0303  AC41 HEK-293T C58(0.96)  LDD1542  [12]
 LDCM0304  AC42 HEK-293T C58(0.92)  LDD1543  [12]
 LDCM0305  AC43 HEK-293T C58(1.03)  LDD1544  [12]
 LDCM0306  AC44 HEK-293T C58(1.01)  LDD1545  [12]
 LDCM0307  AC45 HEK-293T C58(0.94)  LDD1546  [12]
 LDCM0308  AC46 HCT 116 C58(0.89)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C58(0.97)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C58(0.88)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C58(0.52)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C58(0.83)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C58(0.55)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C58(0.85)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C58(0.85)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C58(0.72)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C58(0.82)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C58(0.53)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C58(0.53)  LDD0636  [5]
 LDCM0320  AC57 HEK-293T C58(1.00)  LDD1559  [12]
 LDCM0321  AC58 HEK-293T C58(0.96)  LDD1560  [12]
 LDCM0322  AC59 HEK-293T C58(1.02)  LDD1561  [12]
 LDCM0323  AC6 HCT 116 C58(1.12)  LDD0640  [5]
 LDCM0324  AC60 HEK-293T C58(0.95)  LDD1563  [12]
 LDCM0325  AC61 HEK-293T C58(0.95)  LDD1564  [12]
 LDCM0326  AC62 HEK-293T C58(0.94)  LDD1565  [12]
 LDCM0327  AC63 HEK-293T C58(1.07)  LDD1566  [12]
 LDCM0328  AC64 HEK-293T C58(1.00)  LDD1567  [12]
 LDCM0334  AC7 HCT 116 C58(1.23)  LDD0651  [5]
 LDCM0345  AC8 HCT 116 C58(1.21)  LDD0662  [5]
 LDCM0349  AC83 HCT 116 C58(1.17)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C58(1.18)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C58(1.00)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C58(1.16)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C58(1.17)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C58(1.33)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C58(1.17)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C58(1.28)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C58(1.16)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C58(1.01)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C58(1.06)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C58(0.92)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C58(1.27)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C58(0.95)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C58(1.32)  LDD0681  [5]
 LDCM0248  AKOS034007472 HCT 116 C58(1.23)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C58(1.28)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C58(1.18)  LDD0592  [5]
 LDCM0020  ARS-1620 HCC44 C58(0.98)  LDD2171  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [4]
 LDCM0367  CL1 PaTu 8988t C58(1.01)  LDD1246  [5]
 LDCM0368  CL10 PaTu 8988t C58(0.86)  LDD1247  [5]
 LDCM0369  CL100 HCT 116 C58(0.91)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C58(1.26)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C58(1.23)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C58(1.23)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C58(1.28)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C58(0.77)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C58(0.59)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C58(0.76)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C58(0.76)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C58(0.82)  LDD0695  [5]
 LDCM0379  CL11 PaTu 8988t C58(0.92)  LDD1258  [5]
 LDCM0380  CL110 HCT 116 C58(0.84)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C58(0.61)  LDD0698  [5]
 LDCM0382  CL112 PaTu 8988t C58(1.02)  LDD1261  [5]
 LDCM0383  CL113 PaTu 8988t C58(1.11)  LDD1262  [5]
 LDCM0384  CL114 PaTu 8988t C58(1.02)  LDD1263  [5]
 LDCM0385  CL115 PaTu 8988t C58(1.00)  LDD1264  [5]
 LDCM0386  CL116 PaTu 8988t C58(1.25)  LDD1265  [5]
 LDCM0387  CL117 HEK-293T C58(1.03)  LDD1591  [12]
 LDCM0388  CL118 HEK-293T C58(0.98)  LDD1592  [12]
 LDCM0389  CL119 HEK-293T C58(0.95)  LDD1593  [12]
 LDCM0390  CL12 PaTu 8988t C58(0.77)  LDD1269  [5]
 LDCM0391  CL120 HEK-293T C58(0.98)  LDD1595  [12]
 LDCM0392  CL121 HCT 116 C58(0.58)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C58(0.88)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C58(0.79)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C58(0.54)  LDD0712  [5]
 LDCM0396  CL125 HEK-293T C58(1.14)  LDD1600  [12]
 LDCM0397  CL126 HEK-293T C58(0.98)  LDD1601  [12]
 LDCM0398  CL127 HEK-293T C58(1.02)  LDD1602  [12]
 LDCM0399  CL128 HEK-293T C58(0.97)  LDD1603  [12]
 LDCM0400  CL13 PaTu 8988t C58(0.70)  LDD1279  [5]
 LDCM0401  CL14 PaTu 8988t C58(0.72)  LDD1280  [5]
 LDCM0402  CL15 PaTu 8988t C58(1.08)  LDD1281  [5]
 LDCM0403  CL16 HCT 116 C58(1.13)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C58(1.68)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C58(1.51)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C58(1.08)  LDD0723  [5]
 LDCM0407  CL2 PaTu 8988t C58(0.85)  LDD1286  [5]
 LDCM0408  CL20 HCT 116 C58(1.03)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C58(1.42)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C58(1.38)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C58(1.11)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C58(1.05)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C58(1.32)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C58(1.46)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C58(1.10)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C58(1.31)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C58(1.25)  LDD0734  [5]
 LDCM0418  CL3 PaTu 8988t C58(1.07)  LDD1297  [5]
 LDCM0419  CL30 HCT 116 C58(1.29)  LDD0736  [5]
 LDCM0420  CL31 HEK-293T C58(0.99)  LDD1624  [12]
 LDCM0421  CL32 HEK-293T C58(1.02)  LDD1625  [12]
 LDCM0422  CL33 HEK-293T C58(0.84)  LDD1626  [12]
 LDCM0423  CL34 HEK-293T C58(0.97)  LDD1627  [12]
 LDCM0424  CL35 HEK-293T C58(1.06)  LDD1628  [12]
 LDCM0425  CL36 HEK-293T C58(0.97)  LDD1629  [12]
 LDCM0426  CL37 HEK-293T C58(1.10)  LDD1630  [12]
 LDCM0428  CL39 HEK-293T C58(1.01)  LDD1632  [12]
 LDCM0429  CL4 PaTu 8988t C58(0.98)  LDD1308  [5]
 LDCM0430  CL40 HEK-293T C58(1.06)  LDD1634  [12]
 LDCM0431  CL41 HEK-293T C58(1.03)  LDD1635  [12]
 LDCM0432  CL42 HEK-293T C58(1.01)  LDD1636  [12]
 LDCM0433  CL43 HEK-293T C58(1.04)  LDD1637  [12]
 LDCM0434  CL44 HEK-293T C58(1.05)  LDD1638  [12]
 LDCM0435  CL45 HEK-293T C58(0.96)  LDD1639  [12]
 LDCM0436  CL46 HEK-293T C58(1.06)  LDD1640  [12]
 LDCM0437  CL47 HEK-293T C58(1.07)  LDD1641  [12]
 LDCM0438  CL48 HEK-293T C58(1.01)  LDD1642  [12]
 LDCM0439  CL49 HEK-293T C58(0.93)  LDD1643  [12]
 LDCM0440  CL5 PaTu 8988t C58(0.83)  LDD1319  [5]
 LDCM0441  CL50 HEK-293T C58(0.93)  LDD1645  [12]
 LDCM0443  CL52 HEK-293T C58(0.93)  LDD1646  [12]
 LDCM0444  CL53 HEK-293T C58(0.94)  LDD1647  [12]
 LDCM0445  CL54 HEK-293T C58(0.78)  LDD1648  [12]
 LDCM0446  CL55 HEK-293T C58(1.02)  LDD1649  [12]
 LDCM0447  CL56 HEK-293T C58(0.94)  LDD1650  [12]
 LDCM0448  CL57 HEK-293T C58(0.82)  LDD1651  [12]
 LDCM0449  CL58 HEK-293T C58(0.81)  LDD1652  [12]
 LDCM0450  CL59 HEK-293T C58(0.87)  LDD1653  [12]
 LDCM0451  CL6 PaTu 8988t C58(0.84)  LDD1330  [5]
 LDCM0452  CL60 HEK-293T C58(0.95)  LDD1655  [12]
 LDCM0453  CL61 HCT 116 C58(1.01)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C58(0.99)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C58(0.85)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C58(0.97)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C58(0.97)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C58(0.95)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C58(0.91)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C58(0.81)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C58(0.94)  LDD0778  [5]
 LDCM0462  CL7 PaTu 8988t C58(0.82)  LDD1341  [5]
 LDCM0463  CL70 HCT 116 C58(0.84)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C58(0.82)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C58(1.01)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C58(0.91)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C58(0.90)  LDD0784  [5]
 LDCM0469  CL76 HEK-293T C58(0.99)  LDD1672  [12]
 LDCM0470  CL77 HEK-293T C58(0.90)  LDD1673  [12]
 LDCM0471  CL78 HEK-293T C58(0.95)  LDD1674  [12]
 LDCM0472  CL79 HEK-293T C58(1.04)  LDD1675  [12]
 LDCM0473  CL8 PaTu 8988t C58(1.06)  LDD1352  [5]
 LDCM0474  CL80 HEK-293T C58(0.98)  LDD1677  [12]
 LDCM0475  CL81 HEK-293T C58(1.02)  LDD1678  [12]
 LDCM0476  CL82 HEK-293T C58(0.89)  LDD1679  [12]
 LDCM0477  CL83 HEK-293T C58(0.95)  LDD1680  [12]
 LDCM0478  CL84 HEK-293T C58(0.91)  LDD1681  [12]
 LDCM0479  CL85 HEK-293T C58(1.05)  LDD1682  [12]
 LDCM0480  CL86 HEK-293T C58(0.94)  LDD1683  [12]
 LDCM0481  CL87 HEK-293T C58(0.99)  LDD1684  [12]
 LDCM0482  CL88 HEK-293T C58(1.06)  LDD1685  [12]
 LDCM0483  CL89 HEK-293T C58(1.00)  LDD1686  [12]
 LDCM0484  CL9 PaTu 8988t C58(0.84)  LDD1363  [5]
 LDCM0485  CL90 HEK-293T C58(0.76)  LDD1688  [12]
 LDCM0486  CL91 HCT 116 C58(0.81)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C58(0.92)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C58(0.87)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C58(0.76)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C58(0.82)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C58(0.75)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C58(1.01)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C58(0.82)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C58(0.69)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C58(0.94)  LDD1698  [12]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C24(0.98)  LDD1702  [3]
 LDCM0625  F8 Ramos C58(1.12)  LDD2187  [13]
 LDCM0572  Fragment10 Ramos C58(0.66)  LDD2189  [13]
 LDCM0573  Fragment11 Ramos C58(2.05)  LDD2190  [13]
 LDCM0574  Fragment12 Ramos C58(0.56)  LDD2191  [13]
 LDCM0575  Fragment13 Ramos C58(0.71)  LDD2192  [13]
 LDCM0576  Fragment14 Ramos C58(0.61)  LDD2193  [13]
 LDCM0579  Fragment20 Ramos C58(0.51)  LDD2194  [13]
 LDCM0580  Fragment21 Ramos C58(0.70)  LDD2195  [13]
 LDCM0582  Fragment23 Ramos C58(1.41)  LDD2196  [13]
 LDCM0578  Fragment27 Ramos C58(0.70)  LDD2197  [13]
 LDCM0586  Fragment28 Ramos C58(0.69)  LDD2198  [13]
 LDCM0588  Fragment30 Ramos C58(0.79)  LDD2199  [13]
 LDCM0589  Fragment31 Ramos C58(0.76)  LDD2200  [13]
 LDCM0590  Fragment32 Ramos C58(0.69)  LDD2201  [13]
 LDCM0468  Fragment33 HCT 116 C58(0.91)  LDD0785  [5]
 LDCM0596  Fragment38 Ramos C58(0.63)  LDD2203  [13]
 LDCM0566  Fragment4 Ramos C58(0.89)  LDD2184  [13]
 LDCM0427  Fragment51 HEK-293T C58(1.07)  LDD1631  [12]
 LDCM0610  Fragment52 Ramos C58(0.82)  LDD2204  [13]
 LDCM0614  Fragment56 Ramos C58(1.17)  LDD2205  [13]
 LDCM0569  Fragment7 Ramos C58(0.82)  LDD2186  [13]
 LDCM0571  Fragment9 Ramos C58(0.59)  LDD2188  [13]
 LDCM0022  KB02 HEK-293T C58(1.00)  LDD1492  [12]
 LDCM0023  KB03 HEK-293T C58(1.05)  LDD1497  [12]
 LDCM0024  KB05 IGR37 C58(1.64)  LDD3314  [14]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C24(0.53)  LDD2109  [3]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C24(0.41)  LDD2122  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C24(0.64)  LDD2125  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C24(0.75)  LDD2127  [3]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C58(1.89)  LDD2133  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C24(1.51)  LDD2135  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C24(0.86)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C24(0.85)  LDD2137  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C58(0.87)  LDD2140  [3]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C58(1.05)  LDD2141  [3]
 LDCM0627  NUDT7-COV-1 HEK-293T C58(0.72)  LDD2206  [15]
 LDCM0628  OTUB2-COV-1 HEK-293T C24(2.33)  LDD2207  [15]
 LDCM0021  THZ1 HCT 116 C58(0.98)  LDD2173  [5]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nadh Small molecular drug DB00157

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
14 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
15 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.