Details of the Target

General Information of Target

Target ID LDTP18525
Target Name Protein NipSnap homolog 3A (NIPSNAP3A)
Gene Name NIPSNAP3A
Gene ID 25934
Synonyms
NIPSNAP4; Protein NipSnap homolog 3A; NipSnap3A; Protein NipSnap homolog 4; NipSnap4; Target for Salmonella secreted protein C; TassC
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MACNIPNQRQRTLSTTGEALYEILGLHKGASNEEIKKTYRKLALKHHPDKNPDDPAATEK
FKEINNAHAILTDISKRSIYDKYGSLGLYVAEQFGDENVNTYFMLSSWWAKALFVIVGLL
TGCYFCCCLCCCCNCCCGHCRPESSVPEEDFYVSPEDLEEQIKSDMEKDVDFPVFLQPTN
ANEKTQLIKEGSRSYCTDS
Target Bioclass
Other
Family
NipSnap family
Subcellular location
Cytoplasm, cytosol
Uniprot ID
Q9UFN0
Ensemble ID
ENST00000374767.5
HGNC ID
HGNC:23619
ChEMBL ID
CHEMBL3817722

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y32(20.00)  LDD0260  [1]
TH216
 Probe Info  		Y32(20.00)  LDD0259  [1]
STPyne
 Probe Info  		K166(2.59); K212(5.26)  LDD0277  [2]
Probe 1
 Probe Info  		Y32(22.80)  LDD3495  [3]
DBIA
 Probe Info  		C135(1.14)  LDD3312  [4]
HHS-482
 Probe Info  		Y32(1.28); Y42(1.39)  LDD0285  [5]
HHS-475
 Probe Info  		Y130(0.08)  LDD0264  [6]
5E-2FA
 Probe Info  		N.A.  LDD2235  [7]
m-APA
 Probe Info  		N.A.  LDD2231  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [8]
SF
 Probe Info  		N.A.  LDD0028  [9]
Acrolein
 Probe Info  		N.A.  LDD0217  [10]
AOyne
 Probe Info  		8.20  LDD0443  [11]
HHS-465
 Probe Info  		N.A.  LDD2240  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C135(0.98)  LDD1507  [13]
 LDCM0276  AC17 HEK-293T C135(1.08)  LDD1515  [13]
 LDCM0285  AC25 HEK-293T C135(1.00)  LDD1524  [13]
 LDCM0294  AC33 HEK-293T C135(1.04)  LDD1533  [13]
 LDCM0303  AC41 HEK-293T C135(1.01)  LDD1542  [13]
 LDCM0311  AC49 HEK-293T C135(1.21)  LDD1550  [13]
 LDCM0320  AC57 HEK-293T C135(1.07)  LDD1559  [13]
 LDCM0356  AKOS034007680 HEK-293T C135(0.99)  LDD1570  [13]
 LDCM0369  CL100 HEK-293T C135(1.33)  LDD1573  [13]
 LDCM0373  CL104 HEK-293T C135(0.97)  LDD1577  [13]
 LDCM0377  CL108 HEK-293T C135(1.09)  LDD1581  [13]
 LDCM0382  CL112 HEK-293T C135(1.07)  LDD1586  [13]
 LDCM0386  CL116 HEK-293T C135(1.62)  LDD1590  [13]
 LDCM0391  CL120 HEK-293T C135(1.23)  LDD1595  [13]
 LDCM0395  CL124 HEK-293T C135(1.04)  LDD1599  [13]
 LDCM0399  CL128 HEK-293T C135(0.88)  LDD1603  [13]
 LDCM0403  CL16 HEK-293T C135(1.36)  LDD1607  [13]
 LDCM0404  CL17 HEK-293T C135(0.98)  LDD1608  [13]
 LDCM0416  CL28 HEK-293T C135(1.04)  LDD1620  [13]
 LDCM0417  CL29 HEK-293T C135(0.95)  LDD1621  [13]
 LDCM0429  CL4 HEK-293T C135(1.15)  LDD1633  [13]
 LDCM0430  CL40 HEK-293T C135(0.94)  LDD1634  [13]
 LDCM0431  CL41 HEK-293T C135(1.00)  LDD1635  [13]
 LDCM0440  CL5 HEK-293T C135(0.97)  LDD1644  [13]
 LDCM0443  CL52 HEK-293T C135(0.97)  LDD1646  [13]
 LDCM0444  CL53 HEK-293T C135(1.01)  LDD1647  [13]
 LDCM0456  CL64 HEK-293T C135(0.77)  LDD1659  [13]
 LDCM0457  CL65 HEK-293T C135(1.05)  LDD1660  [13]
 LDCM0469  CL76 HEK-293T C135(1.42)  LDD1672  [13]
 LDCM0470  CL77 HEK-293T C135(0.87)  LDD1673  [13]
 LDCM0482  CL88 HEK-293T C135(1.00)  LDD1685  [13]
 LDCM0483  CL89 HEK-293T C135(1.02)  LDD1686  [13]
 LDCM0116  HHS-0101 DM93 Y130(0.08)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y42(15.37)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y130(0.66); Y42(8.69)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y42(6.21)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y42(10.82)  LDD0268  [6]
 LDCM0123  JWB131 DM93 Y32(1.28); Y42(1.39)  LDD0285  [5]
 LDCM0124  JWB142 DM93 Y32(1.86); Y42(1.68)  LDD0286  [5]
 LDCM0125  JWB146 DM93 Y32(1.42); Y42(1.43)  LDD0287  [5]
 LDCM0126  JWB150 DM93 Y32(3.25); Y42(3.80)  LDD0288  [5]
 LDCM0127  JWB152 DM93 Y32(2.99); Y42(3.21)  LDD0289  [5]
 LDCM0128  JWB198 DM93 Y32(0.21); Y42(0.55)  LDD0290  [5]
 LDCM0129  JWB202 DM93 Y32(2.94); Y42(11.66)  LDD0291  [5]
 LDCM0130  JWB211 DM93 Y32(2.17); Y42(1.84)  LDD0292  [5]
 LDCM0022  KB02 22RV1 C135(0.93)  LDD2243  [4]
 LDCM0023  KB03 22RV1 C135(1.13)  LDD2660  [4]
 LDCM0024  KB05 HMCB C135(1.14)  LDD3312  [4]
 LDCM0109  NEM HeLa N.A.  LDD0223  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tumor protein 63 (TP63) P53 family Q9H3D4
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402