Details of the Target

General Information of Target

Target ID LDTP17588
Target Name Transmembrane protein 200A (TMEM200A)
Gene Name TMEM200A
Gene ID 114801
Synonyms
KIAA1913; Transmembrane protein 200A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTQPVPRLSVPAALALGSAALGAAFATGLFLGRRCPPWRGRREQCLLPPEDSRLWQYLLS
RSMREHPALRSLRLLTLEQPQGDSMMTCEQAQLLANLARLIQAKKALDLGTFTGYSALAL
ALALPADGRVVTCEVDAQPPELGRPLWRQAEAEHKIDLRLKPALETLDELLAAGEAGTFD
VAVVDADKENCSAYYERCLQLLRPGGILAVLRVLWRGKVLQPPKGDVAAECVRNLNERIR
RDVRVYISLLPLGDGLTLAFKI
Target Bioclass
Other
Family
TMEM200 family
Subcellular location
Membrane
Uniprot ID
Q86VY9
Ensemble ID
ENST00000296978.4
HGNC ID
HGNC:21075

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C201(1.61)  LDD0532  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HCT 116 C201(1.61)  LDD0532  [1]
 LDCM0226  AC11 HCT 116 C201(1.13)  LDD0543  [1]
 LDCM0230  AC113 HCT 116 C201(2.02)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C201(1.60)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C201(1.32)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C201(2.18)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C201(1.17)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C201(1.03)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C201(1.14)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C201(1.17)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C201(1.20)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C201(1.13)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C201(1.05)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C201(1.25)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C201(1.30)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C201(1.09)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C201(1.56)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C201(1.63)  LDD0562  [1]
 LDCM0259  AC14 HCT 116 C201(1.06)  LDD0576  [1]
 LDCM0270  AC15 HCT 116 C201(2.02)  LDD0587  [1]
 LDCM0285  AC25 HCT 116 C201(0.77)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C201(1.32)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C201(1.28)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C201(1.15)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C201(1.19)  LDD0606  [1]
 LDCM0291  AC30 HCT 116 C201(1.56)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C201(1.08)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C201(1.41)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C201(1.65)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C201(1.76)  LDD0612  [1]
 LDCM0308  AC46 HCT 116 C201(0.97)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C201(1.18)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C201(1.27)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C201(1.54)  LDD0628  [1]
 LDCM0313  AC50 HCT 116 C201(1.60)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C201(0.84)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C201(1.17)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C201(1.32)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C201(1.37)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C201(1.77)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C201(2.34)  LDD0636  [1]
 LDCM0323  AC6 HCT 116 C201(0.91)  LDD0640  [1]
 LDCM0332  AC68 HCT 116 C201(0.76)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C201(0.90)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C201(0.94)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C201(0.65)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C201(1.20)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C201(1.01)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C201(1.16)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C201(1.62)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C201(2.91)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C201(1.31)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C201(1.12)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C201(0.84)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C201(1.13)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C201(1.34)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C201(1.32)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C201(1.17)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C201(2.62)  LDD0665  [1]
 LDCM0248  AKOS034007472 HCT 116 C201(1.10)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C201(1.27)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C201(1.50)  LDD0592  [1]
 LDCM0370  CL101 HCT 116 C201(2.21)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C201(1.23)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C201(0.89)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C201(0.85)  LDD0690  [1]
 LDCM0382  CL112 HCT 116 C201(0.78)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C201(1.63)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C201(1.81)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C201(1.06)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C201(1.20)  LDD0703  [1]
 LDCM0392  CL121 HCT 116 C201(0.54)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C201(1.11)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C201(2.22)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C201(1.22)  LDD0712  [1]
 LDCM0403  CL16 HCT 116 C201(0.65)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C201(1.05)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C201(1.28)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C201(0.81)  LDD0723  [1]
 LDCM0408  CL20 HCT 116 C201(0.93)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C201(1.41)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C201(1.87)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C201(1.18)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C201(1.05)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C201(1.24)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C201(0.95)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C201(0.91)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C201(0.87)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C201(0.88)  LDD0734  [1]
 LDCM0419  CL30 HCT 116 C201(0.71)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C201(1.22)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C201(1.33)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C201(1.31)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C201(1.67)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C201(1.94)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C201(2.85)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C201(2.22)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C201(1.89)  LDD0745  [1]
 LDCM0430  CL40 HCT 116 C201(1.19)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C201(1.50)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C201(2.41)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C201(2.26)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C201(2.22)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C201(1.89)  LDD0752  [1]
 LDCM0453  CL61 HCT 116 C201(0.98)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C201(1.28)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C201(1.50)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C201(1.77)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C201(1.18)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C201(1.55)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C201(1.33)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C201(1.56)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C201(1.52)  LDD0778  [1]
 LDCM0463  CL70 HCT 116 C201(1.15)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C201(1.44)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C201(1.12)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C201(1.29)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C201(1.37)  LDD0784  [1]
 LDCM0469  CL76 HCT 116 C201(3.44)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C201(1.12)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C201(0.97)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C201(1.23)  LDD0789  [1]
 LDCM0474  CL80 HCT 116 C201(0.90)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C201(1.08)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C201(5.06)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C201(1.70)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C201(1.96)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C201(1.69)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C201(1.04)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C201(1.55)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C201(1.50)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C201(3.16)  LDD0800  [1]
 LDCM0485  CL90 HCT 116 C201(2.21)  LDD0802  [1]
 LDCM0468  Fragment33 HCT 116 C201(1.50)  LDD0785  [1]
 LDCM0427  Fragment51 HCT 116 C201(1.64)  LDD0744  [1]
 LDCM0022  KB02 MKN-1 C201(3.10)  LDD2497  [2]
 LDCM0023  KB03 MKN-1 C201(6.14)  LDD2914  [2]
 LDCM0024  KB05 MKN-1 C201(5.01)  LDD3331  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bcl-2-like protein 10 (BCL2L10) Bcl-2 family Q9HD36
Protein unc-119 homolog A (UNC119) PDE6D/unc-119 family Q13432
Emerin (EMD) . P50402

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840