Details of the Target

General Information of Target

Target ID LDTP17236
Target Name Queuosine 5'-phosphate N-glycosylase/hydrolase (QNG1)
Gene Name QNG1
Gene ID 84267
Synonyms
C9orf64; Queuosine 5'-phosphate N-glycosylase/hydrolase; EC 3.2.2.-; Q-nucleotide N-glycosylase 1; Queuine salvage protein QNG1; Queuosine-nucleotide N-glycosylase/hydrolase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAPGALLVMGVSGSGKSTVGALLASELGWKFYDADDYHPEENRRKMGKGIPLNDQDRIP
WLCNLHDILLRDVASGQRVVLACSALKKTYRDILTQGKDGVALKCEESGKEAKQAEMQLL
VVHLSGSFEVISGRLLKREGHFMPPELLQSQFETLEPPAAPENFIQISVDKNVSEIIATI
METLKMK
Target Bioclass
Enzyme
Family
Queuosine salvage protein family
Function
Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly. In vitro, can also catalyze the release of the q base directly from Q as substrate; however, it was shown that Q is not the biologically relevant substrate. Shows a very low activity on queuosine 3',5'-diphosphate, and cannot release q from queuosine 3'-phosphate and from the 5'-nucleotides AMP, UMP, CMP or GMP, indicating specificity for the queuine base. Can complement the yeast mutant SPAC589.05c, restoring Q incorporation into tRNA.
Uniprot ID
Q5T6V5
Ensemble ID
ENST00000376344.8
HGNC ID
HGNC:28144

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K38(6.91)  LDD0277  [1]
Probe 1
 Probe Info  		Y270(13.29)  LDD3495  [2]
m-APA
 Probe Info  		12.93  LDD0403  [3]
DBIA
 Probe Info  		C170(1.62); C227(0.96)  LDD3312  [4]
BTD
 Probe Info  		C227(1.83)  LDD1700  [5]
Acrolein
 Probe Info  		N.A.  LDD0221  [6]
5E-2FA
 Probe Info  		N.A.  LDD2235  [7]
ATP probe
 Probe Info  		N.A.  LDD0199  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C292(0.00); C170(0.00); C103(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [10]
Lodoacetamide azide
 Probe Info  		C292(0.00); C170(0.00); C103(0.00)  LDD0037  [9]
WYneN
 Probe Info  		C227(0.00); C292(0.00)  LDD0021  [11]
IPM
 Probe Info  		N.A.  LDD0005  [11]
NHS
 Probe Info  		N.A.  LDD0010  [11]
TFBX
 Probe Info  		N.A.  LDD0148  [12]
W1
 Probe Info  		N.A.  LDD0236  [13]
NAIA_5
 Probe Info  		N.A.  LDD2223  [14]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		12.35  LDD0475  [15]
FFF probe2
 Probe Info  		11.19  LDD0463  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C227(1.03)  LDD2117  [5]
 LDCM0214  AC1 HEK-293T C170(0.78); C292(0.84)  LDD0812  [16]
 LDCM0215  AC10 HEK-293T C170(0.97); C292(1.09)  LDD0813  [16]
 LDCM0216  AC100 HEK-293T C170(0.78); C281(1.27)  LDD0814  [16]
 LDCM0217  AC101 HEK-293T C170(0.98); C281(1.01)  LDD0815  [16]
 LDCM0218  AC102 HEK-293T C170(0.75); C281(1.20)  LDD0816  [16]
 LDCM0219  AC103 HEK-293T C170(0.62); C281(1.03)  LDD0817  [16]
 LDCM0220  AC104 HEK-293T C170(0.47); C281(0.99)  LDD0818  [16]
 LDCM0221  AC105 HEK-293T C170(1.07); C281(0.81)  LDD0819  [16]
 LDCM0222  AC106 HEK-293T C170(1.87); C281(1.29)  LDD0820  [16]
 LDCM0223  AC107 HEK-293T C170(0.75); C281(1.04)  LDD0821  [16]
 LDCM0224  AC108 HEK-293T C170(1.44); C281(0.84)  LDD0822  [16]
 LDCM0225  AC109 HEK-293T C170(1.25); C281(1.57)  LDD0823  [16]
 LDCM0226  AC11 HEK-293T C170(0.98); C292(1.07)  LDD0824  [16]
 LDCM0227  AC110 HEK-293T C170(0.22); C281(1.34)  LDD0825  [16]
 LDCM0228  AC111 HEK-293T C170(0.13); C281(1.51)  LDD0826  [16]
 LDCM0229  AC112 HEK-293T C170(0.16); C281(1.49)  LDD0827  [16]
 LDCM0230  AC113 HEK-293T C170(1.09); C281(1.04)  LDD0828  [16]
 LDCM0231  AC114 HEK-293T C170(1.09); C281(0.63)  LDD0829  [16]
 LDCM0232  AC115 HEK-293T C170(1.11); C281(0.54)  LDD0830  [16]
 LDCM0233  AC116 HEK-293T C170(1.13); C281(0.84)  LDD0831  [16]
 LDCM0234  AC117 HEK-293T C170(0.62); C281(0.79)  LDD0832  [16]
 LDCM0235  AC118 HEK-293T C170(0.61); C281(0.71)  LDD0833  [16]
 LDCM0236  AC119 HEK-293T C170(0.61); C281(0.85)  LDD0834  [16]
 LDCM0237  AC12 HEK-293T C170(0.65); C292(0.99)  LDD0835  [16]
 LDCM0238  AC120 HEK-293T C170(0.63); C281(1.22)  LDD0836  [16]
 LDCM0239  AC121 HEK-293T C170(0.52); C281(1.04)  LDD0837  [16]
 LDCM0240  AC122 HEK-293T C170(0.35); C281(1.04)  LDD0838  [16]
 LDCM0241  AC123 HEK-293T C170(0.30); C281(1.03)  LDD0839  [16]
 LDCM0242  AC124 HEK-293T C170(0.55); C281(0.84)  LDD0840  [16]
 LDCM0243  AC125 HEK-293T C170(0.37); C281(0.78)  LDD0841  [16]
 LDCM0244  AC126 HEK-293T C170(0.13); C281(1.13)  LDD0842  [16]
 LDCM0245  AC127 HEK-293T C170(0.10); C281(1.13)  LDD0843  [16]
 LDCM0246  AC128 HEK-293T C170(4.38); C281(1.40); C292(1.27)  LDD0844  [16]
 LDCM0247  AC129 HEK-293T C170(0.73); C281(1.58); C292(1.11)  LDD0845  [16]
 LDCM0249  AC130 HEK-293T C170(1.09); C281(1.71); C292(1.15)  LDD0847  [16]
 LDCM0250  AC131 HEK-293T C170(1.29); C281(1.09); C292(1.32)  LDD0848  [16]
 LDCM0251  AC132 HEK-293T C170(1.52); C281(1.09); C292(1.19)  LDD0849  [16]
 LDCM0252  AC133 HEK-293T C170(0.80); C281(1.22); C292(1.27)  LDD0850  [16]
 LDCM0253  AC134 HEK-293T C170(0.86); C281(1.16); C292(1.15)  LDD0851  [16]
 LDCM0254  AC135 HEK-293T C170(0.58); C281(1.36); C292(1.11)  LDD0852  [16]
 LDCM0255  AC136 HEK-293T C170(0.56); C281(1.71); C292(1.31)  LDD0853  [16]
 LDCM0256  AC137 HEK-293T C170(0.36); C281(1.75); C292(1.27)  LDD0854  [16]
 LDCM0257  AC138 HEK-293T C170(0.28); C281(1.70); C292(1.33)  LDD0855  [16]
 LDCM0258  AC139 HEK-293T C170(0.40); C281(1.54); C292(1.31)  LDD0856  [16]
 LDCM0259  AC14 HEK-293T C170(1.04); C292(1.05)  LDD0857  [16]
 LDCM0260  AC140 HEK-293T C170(0.70); C281(1.17); C292(1.46)  LDD0858  [16]
 LDCM0261  AC141 HEK-293T C170(0.46); C281(1.94); C292(1.58)  LDD0859  [16]
 LDCM0262  AC142 HEK-293T C170(0.75); C281(1.52); C292(1.25)  LDD0860  [16]
 LDCM0263  AC143 HEK-293T C170(0.46); C292(0.99)  LDD0861  [16]
 LDCM0264  AC144 HEK-293T C170(0.50); C292(1.01)  LDD0862  [16]
 LDCM0265  AC145 HEK-293T C170(0.49); C292(1.01)  LDD0863  [16]
 LDCM0266  AC146 HEK-293T C170(0.38); C292(1.16)  LDD0864  [16]
 LDCM0267  AC147 HEK-293T C170(0.34); C292(1.19)  LDD0865  [16]
 LDCM0268  AC148 HEK-293T C170(0.54); C292(1.13)  LDD0866  [16]
 LDCM0269  AC149 HEK-293T C170(0.58); C292(1.01)  LDD0867  [16]
 LDCM0270  AC15 HEK-293T C170(0.78); C292(1.30)  LDD0868  [16]
 LDCM0271  AC150 HEK-293T C170(0.75); C292(0.88)  LDD0869  [16]
 LDCM0272  AC151 HEK-293T C170(0.69); C292(1.05)  LDD0870  [16]
 LDCM0273  AC152 HEK-293T C170(0.71); C292(0.90)  LDD0871  [16]
 LDCM0274  AC153 HEK-293T C170(0.71); C292(1.01)  LDD0872  [16]
 LDCM0621  AC154 HEK-293T C170(0.90); C292(1.03)  LDD2162  [16]
 LDCM0622  AC155 HEK-293T C170(0.75); C292(0.99)  LDD2163  [16]
 LDCM0623  AC156 HEK-293T C170(0.41); C292(1.11)  LDD2164  [16]
 LDCM0624  AC157 HEK-293T C170(0.22); C292(1.25)  LDD2165  [16]
 LDCM0276  AC17 HEK-293T C170(0.60); C281(1.07); C292(0.72)  LDD0874  [16]
 LDCM0277  AC18 HEK-293T C170(0.63); C281(1.02); C292(0.69)  LDD0875  [16]
 LDCM0278  AC19 HEK-293T C170(0.83); C281(0.96); C292(0.76)  LDD0876  [16]
 LDCM0279  AC2 HEK-293T C170(0.94); C292(0.94)  LDD0877  [16]
 LDCM0280  AC20 HEK-293T C170(0.67); C281(0.92); C292(0.80)  LDD0878  [16]
 LDCM0281  AC21 HEK-293T C170(0.67); C281(1.24); C292(0.82)  LDD0879  [16]
 LDCM0282  AC22 HEK-293T C170(0.44); C281(1.22); C292(0.72)  LDD0880  [16]
 LDCM0283  AC23 HEK-293T C170(0.45); C281(1.33); C292(0.79)  LDD0881  [16]
 LDCM0284  AC24 HEK-293T C170(0.56); C281(0.82); C292(0.73)  LDD0882  [16]
 LDCM0285  AC25 HEK-293T C170(0.66); C281(1.10); C292(0.84)  LDD0883  [16]
 LDCM0286  AC26 HEK-293T C170(0.63); C281(1.17); C292(0.79)  LDD0884  [16]
 LDCM0287  AC27 HEK-293T C170(0.69); C281(1.27); C292(0.89)  LDD0885  [16]
 LDCM0288  AC28 HEK-293T C170(0.63); C281(0.85); C292(1.13)  LDD0886  [16]
 LDCM0289  AC29 HEK-293T C170(0.34); C281(1.12); C292(0.68)  LDD0887  [16]
 LDCM0290  AC3 HEK-293T C170(1.07); C292(1.00)  LDD0888  [16]
 LDCM0291  AC30 HEK-293T C170(0.62); C281(1.26); C292(0.74)  LDD0889  [16]
 LDCM0292  AC31 HEK-293T C170(0.72); C281(1.26); C292(0.95)  LDD0890  [16]
 LDCM0293  AC32 HEK-293T C170(0.66); C281(1.31); C292(0.74)  LDD0891  [16]
 LDCM0294  AC33 HEK-293T C170(0.55); C281(1.31); C292(0.68)  LDD0892  [16]
 LDCM0295  AC34 HEK-293T C170(0.74); C281(1.27); C292(0.72)  LDD0893  [16]
 LDCM0296  AC35 HEK-293T C170(1.05)  LDD0894  [16]
 LDCM0297  AC36 HEK-293T C170(0.87)  LDD0895  [16]
 LDCM0298  AC37 HEK-293T C170(0.86)  LDD0896  [16]
 LDCM0299  AC38 HEK-293T C170(0.76)  LDD0897  [16]
 LDCM0300  AC39 HEK-293T C170(0.97)  LDD0898  [16]
 LDCM0301  AC4 HEK-293T C170(1.22); C292(1.09)  LDD0899  [16]
 LDCM0302  AC40 HEK-293T C170(0.86)  LDD0900  [16]
 LDCM0303  AC41 HEK-293T C170(0.87)  LDD0901  [16]
 LDCM0304  AC42 HEK-293T C170(0.93)  LDD0902  [16]
 LDCM0305  AC43 HEK-293T C170(0.37)  LDD0903  [16]
 LDCM0306  AC44 HEK-293T C170(0.71)  LDD0904  [16]
 LDCM0307  AC45 HEK-293T C170(0.85)  LDD0905  [16]
 LDCM0308  AC46 HEK-293T C170(0.83); C292(1.11)  LDD0906  [16]
 LDCM0309  AC47 HEK-293T C170(0.68); C292(0.96)  LDD0907  [16]
 LDCM0310  AC48 HEK-293T C170(0.67); C292(0.94)  LDD0908  [16]
 LDCM0311  AC49 HEK-293T C170(0.69); C292(0.80)  LDD0909  [16]
 LDCM0312  AC5 HEK-293T C170(0.70); C292(0.85)  LDD0910  [16]
 LDCM0313  AC50 HEK-293T C170(0.74); C292(0.78)  LDD0911  [16]
 LDCM0314  AC51 HEK-293T C170(0.51); C292(0.80)  LDD0912  [16]
 LDCM0315  AC52 HEK-293T C170(0.55); C292(0.83)  LDD0913  [16]
 LDCM0316  AC53 HEK-293T C170(0.68); C292(0.95)  LDD0914  [16]
 LDCM0317  AC54 HEK-293T C170(0.56); C292(0.83)  LDD0915  [16]
 LDCM0318  AC55 HEK-293T C170(0.58); C292(0.82)  LDD0916  [16]
 LDCM0319  AC56 HEK-293T C170(0.59); C292(0.91)  LDD0917  [16]
 LDCM0320  AC57 HEK-293T C170(1.48); C292(0.94)  LDD0918  [16]
 LDCM0321  AC58 HEK-293T C170(1.51); C292(1.04)  LDD0919  [16]
 LDCM0322  AC59 HEK-293T C170(1.70); C292(1.07)  LDD0920  [16]
 LDCM0323  AC6 HEK-293T C170(0.91); C292(1.02)  LDD0921  [16]
 LDCM0324  AC60 HEK-293T C170(2.19); C292(0.82)  LDD0922  [16]
 LDCM0325  AC61 HEK-293T C170(0.71); C292(0.90)  LDD0923  [16]
 LDCM0326  AC62 HEK-293T C170(1.27); C292(1.14)  LDD0924  [16]
 LDCM0327  AC63 HEK-293T C170(1.01); C292(0.93)  LDD0925  [16]
 LDCM0328  AC64 HEK-293T C170(1.44); C292(0.98)  LDD0926  [16]
 LDCM0329  AC65 HEK-293T C170(1.03); C292(0.92)  LDD0927  [16]
 LDCM0330  AC66 HEK-293T C170(1.45); C292(0.97)  LDD0928  [16]
 LDCM0331  AC67 HEK-293T C170(1.09); C292(0.83)  LDD0929  [16]
 LDCM0332  AC68 HEK-293T C170(0.91); C292(0.97)  LDD0930  [16]
 LDCM0333  AC69 HEK-293T C170(0.97); C292(1.02)  LDD0931  [16]
 LDCM0334  AC7 HEK-293T C170(0.84); C292(1.14)  LDD0932  [16]
 LDCM0335  AC70 HEK-293T C170(0.71); C292(1.12)  LDD0933  [16]
 LDCM0336  AC71 HEK-293T C170(0.64); C292(1.04)  LDD0934  [16]
 LDCM0337  AC72 HEK-293T C170(0.79); C292(0.91)  LDD0935  [16]
 LDCM0338  AC73 HEK-293T C170(0.72); C292(1.00)  LDD0936  [16]
 LDCM0339  AC74 HEK-293T C170(0.72); C292(1.69)  LDD0937  [16]
 LDCM0340  AC75 HEK-293T C170(0.75); C292(1.02)  LDD0938  [16]
 LDCM0341  AC76 HEK-293T C170(0.86); C292(0.97)  LDD0939  [16]
 LDCM0342  AC77 HEK-293T C170(0.75); C292(1.16)  LDD0940  [16]
 LDCM0343  AC78 HEK-293T C170(0.67); C292(0.95)  LDD0941  [16]
 LDCM0344  AC79 HEK-293T C170(0.83); C292(1.24)  LDD0942  [16]
 LDCM0345  AC8 HEK-293T C170(0.79); C292(0.92)  LDD0943  [16]
 LDCM0346  AC80 HEK-293T C170(0.41); C292(0.88)  LDD0944  [16]
 LDCM0347  AC81 HEK-293T C170(0.82); C292(1.07)  LDD0945  [16]
 LDCM0348  AC82 HEK-293T C170(0.29); C292(0.99)  LDD0946  [16]
 LDCM0349  AC83 HEK-293T C170(1.07); C292(0.88)  LDD0947  [16]
 LDCM0350  AC84 HEK-293T C170(0.59); C292(0.73)  LDD0948  [16]
 LDCM0351  AC85 HEK-293T C170(0.68); C292(0.83)  LDD0949  [16]
 LDCM0352  AC86 HEK-293T C170(0.87); C292(0.86)  LDD0950  [16]
 LDCM0353  AC87 HEK-293T C170(0.83); C292(0.88)  LDD0951  [16]
 LDCM0354  AC88 HEK-293T C170(0.70); C292(0.80)  LDD0952  [16]
 LDCM0355  AC89 HEK-293T C170(0.42); C292(0.71)  LDD0953  [16]
 LDCM0357  AC90 HEK-293T C170(0.45); C292(0.74)  LDD0955  [16]
 LDCM0358  AC91 HEK-293T C170(0.68); C292(0.84)  LDD0956  [16]
 LDCM0359  AC92 HEK-293T C170(0.65); C292(0.81)  LDD0957  [16]
 LDCM0360  AC93 HEK-293T C170(0.42); C292(0.87)  LDD0958  [16]
 LDCM0361  AC94 HEK-293T C170(0.59); C292(0.97)  LDD0959  [16]
 LDCM0362  AC95 HEK-293T C170(0.56); C292(0.78)  LDD0960  [16]
 LDCM0363  AC96 HEK-293T C170(0.17); C292(0.77)  LDD0961  [16]
 LDCM0364  AC97 HEK-293T C170(0.10); C292(0.92)  LDD0962  [16]
 LDCM0365  AC98 HEK-293T C170(1.15); C281(1.03)  LDD0963  [16]
 LDCM0366  AC99 HEK-293T C170(1.05); C281(1.37)  LDD0964  [16]
 LDCM0248  AKOS034007472 HEK-293T C170(1.00); C292(1.17)  LDD0846  [16]
 LDCM0356  AKOS034007680 HEK-293T C170(0.74); C292(1.07)  LDD0954  [16]
 LDCM0275  AKOS034007705 HEK-293T C170(0.83); C292(1.09)  LDD0873  [16]
 LDCM0156  Aniline NCI-H1299 12.93  LDD0403  [3]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [6]
 LDCM0367  CL1 HEK-293T C170(0.87); C292(0.90)  LDD0965  [16]
 LDCM0368  CL10 HEK-293T C170(0.09); C292(1.08)  LDD0966  [16]
 LDCM0369  CL100 HEK-293T C170(0.60); C292(0.94)  LDD0967  [16]
 LDCM0370  CL101 HEK-293T C170(0.71); C292(0.99)  LDD0968  [16]
 LDCM0371  CL102 HEK-293T C170(0.73); C292(1.01)  LDD0969  [16]
 LDCM0372  CL103 HEK-293T C170(0.70); C292(1.11)  LDD0970  [16]
 LDCM0373  CL104 HEK-293T C170(0.92); C292(1.05)  LDD0971  [16]
 LDCM0374  CL105 HEK-293T C170(0.50); C281(1.32); C292(0.78)  LDD0972  [16]
 LDCM0375  CL106 HEK-293T C170(0.58); C281(1.04); C292(0.86)  LDD0973  [16]
 LDCM0376  CL107 HEK-293T C170(0.86); C281(0.76); C292(0.80)  LDD0974  [16]
 LDCM0377  CL108 HEK-293T C170(0.90); C281(1.10); C292(0.78)  LDD0975  [16]
 LDCM0378  CL109 HEK-293T C170(0.60); C281(1.06); C292(0.79)  LDD0976  [16]
 LDCM0379  CL11 HEK-293T C170(0.16); C292(1.01)  LDD0977  [16]
 LDCM0380  CL110 HEK-293T C170(0.58); C281(1.31); C292(0.72)  LDD0978  [16]
 LDCM0381  CL111 HEK-293T C170(0.73); C281(1.21); C292(0.76)  LDD0979  [16]
 LDCM0382  CL112 HEK-293T C170(0.53); C281(1.30); C292(0.81)  LDD0980  [16]
 LDCM0383  CL113 HEK-293T C170(0.76); C281(1.32); C292(0.74)  LDD0981  [16]
 LDCM0384  CL114 HEK-293T C170(0.38); C281(1.92); C292(0.70)  LDD0982  [16]
 LDCM0385  CL115 HEK-293T C170(0.61); C281(1.37); C292(0.71)  LDD0983  [16]
 LDCM0386  CL116 HEK-293T C170(0.45); C281(1.55); C292(0.69)  LDD0984  [16]
 LDCM0387  CL117 HEK-293T C170(0.89)  LDD0985  [16]
 LDCM0388  CL118 HEK-293T C170(0.83)  LDD0986  [16]
 LDCM0389  CL119 HEK-293T C170(0.81)  LDD0987  [16]
 LDCM0390  CL12 HEK-293T C170(1.00); C292(0.83)  LDD0988  [16]
 LDCM0391  CL120 HEK-293T C170(0.91)  LDD0989  [16]
 LDCM0392  CL121 HEK-293T C170(0.63); C292(0.91)  LDD0990  [16]
 LDCM0393  CL122 HEK-293T C170(0.65); C292(0.86)  LDD0991  [16]
 LDCM0394  CL123 HEK-293T C170(0.62); C292(0.79)  LDD0992  [16]
 LDCM0395  CL124 HEK-293T C170(0.71); C292(0.85)  LDD0993  [16]
 LDCM0396  CL125 HEK-293T C170(1.32); C292(0.92)  LDD0994  [16]
 LDCM0397  CL126 HEK-293T C170(1.66); C292(0.97)  LDD0995  [16]
 LDCM0398  CL127 HEK-293T C170(1.62); C292(1.26)  LDD0996  [16]
 LDCM0399  CL128 HEK-293T C170(1.34); C292(1.16)  LDD0997  [16]
 LDCM0400  CL13 HEK-293T C170(0.68); C292(0.89)  LDD0998  [16]
 LDCM0401  CL14 HEK-293T C170(0.57); C292(0.96)  LDD0999  [16]
 LDCM0402  CL15 HEK-293T C170(0.38); C292(0.81)  LDD1000  [16]
 LDCM0403  CL16 HEK-293T C170(1.60)  LDD1001  [16]
 LDCM0404  CL17 HEK-293T C170(1.35)  LDD1002  [16]
 LDCM0405  CL18 HEK-293T C170(0.72)  LDD1003  [16]
 LDCM0406  CL19 HEK-293T C170(0.99)  LDD1004  [16]
 LDCM0407  CL2 HEK-293T C170(0.97); C292(0.82)  LDD1005  [16]
 LDCM0408  CL20 HEK-293T C170(1.06)  LDD1006  [16]
 LDCM0409  CL21 HEK-293T C170(0.68)  LDD1007  [16]
 LDCM0410  CL22 HEK-293T C170(0.90)  LDD1008  [16]
 LDCM0411  CL23 HEK-293T C170(1.74)  LDD1009  [16]
 LDCM0412  CL24 HEK-293T C170(1.10)  LDD1010  [16]
 LDCM0413  CL25 HEK-293T C170(0.79)  LDD1011  [16]
 LDCM0414  CL26 HEK-293T C170(0.57)  LDD1012  [16]
 LDCM0415  CL27 HEK-293T C170(0.79)  LDD1013  [16]
 LDCM0416  CL28 HEK-293T C170(1.40)  LDD1014  [16]
 LDCM0417  CL29 HEK-293T C170(1.37)  LDD1015  [16]
 LDCM0418  CL3 HEK-293T C170(0.70); C292(0.85)  LDD1016  [16]
 LDCM0419  CL30 HEK-293T C170(0.44)  LDD1017  [16]
 LDCM0420  CL31 HEK-293T C170(0.83)  LDD1018  [16]
 LDCM0421  CL32 HEK-293T C170(0.86)  LDD1019  [16]
 LDCM0422  CL33 HEK-293T C170(0.72)  LDD1020  [16]
 LDCM0423  CL34 HEK-293T C170(0.94)  LDD1021  [16]
 LDCM0424  CL35 HEK-293T C170(0.75)  LDD1022  [16]
 LDCM0425  CL36 HEK-293T C170(0.81)  LDD1023  [16]
 LDCM0426  CL37 HEK-293T C170(0.79)  LDD1024  [16]
 LDCM0428  CL39 HEK-293T C170(0.26)  LDD1026  [16]
 LDCM0429  CL4 HEK-293T C170(0.66); C292(0.88)  LDD1027  [16]
 LDCM0430  CL40 HEK-293T C170(0.70)  LDD1028  [16]
 LDCM0431  CL41 HEK-293T C170(0.42)  LDD1029  [16]
 LDCM0432  CL42 HEK-293T C170(0.36)  LDD1030  [16]
 LDCM0433  CL43 HEK-293T C170(0.33)  LDD1031  [16]
 LDCM0434  CL44 HEK-293T C170(0.73)  LDD1032  [16]
 LDCM0435  CL45 HEK-293T C170(0.42)  LDD1033  [16]
 LDCM0436  CL46 PaTu 8988t C170(1.04)  LDD1315  [16]
 LDCM0437  CL47 PaTu 8988t C170(0.87)  LDD1316  [16]
 LDCM0438  CL48 PaTu 8988t C170(0.96)  LDD1317  [16]
 LDCM0439  CL49 PaTu 8988t C170(1.13)  LDD1318  [16]
 LDCM0440  CL5 HEK-293T C170(0.80); C292(0.85)  LDD1038  [16]
 LDCM0441  CL50 PaTu 8988t C170(0.84)  LDD1320  [16]
 LDCM0442  CL51 PaTu 8988t C170(0.88)  LDD1321  [16]
 LDCM0443  CL52 PaTu 8988t C170(1.04)  LDD1322  [16]
 LDCM0444  CL53 PaTu 8988t C170(0.70)  LDD1323  [16]
 LDCM0445  CL54 PaTu 8988t C170(1.01)  LDD1324  [16]
 LDCM0446  CL55 PaTu 8988t C170(1.21)  LDD1325  [16]
 LDCM0447  CL56 PaTu 8988t C170(0.13)  LDD1326  [16]
 LDCM0448  CL57 PaTu 8988t C170(0.11)  LDD1327  [16]
 LDCM0449  CL58 PaTu 8988t C170(0.60)  LDD1328  [16]
 LDCM0450  CL59 PaTu 8988t C170(0.12)  LDD1329  [16]
 LDCM0451  CL6 HEK-293T C170(0.73); C292(0.86)  LDD1049  [16]
 LDCM0452  CL60 PaTu 8988t C170(0.17)  LDD1331  [16]
 LDCM0453  CL61 HEK-293T C170(0.94); C292(0.85)  LDD1051  [16]
 LDCM0454  CL62 HEK-293T C170(0.82); C292(0.89)  LDD1052  [16]
 LDCM0455  CL63 HEK-293T C170(0.63); C292(0.76)  LDD1053  [16]
 LDCM0456  CL64 HEK-293T C170(0.82); C292(0.88)  LDD1054  [16]
 LDCM0457  CL65 HEK-293T C170(0.77); C292(0.76)  LDD1055  [16]
 LDCM0458  CL66 HEK-293T C170(0.77); C292(0.87)  LDD1056  [16]
 LDCM0459  CL67 HEK-293T C170(0.82); C292(0.88)  LDD1057  [16]
 LDCM0460  CL68 HEK-293T C170(0.37); C292(0.85)  LDD1058  [16]
 LDCM0461  CL69 HEK-293T C170(0.83); C292(0.91)  LDD1059  [16]
 LDCM0462  CL7 HEK-293T C170(0.62); C292(0.92)  LDD1060  [16]
 LDCM0463  CL70 HEK-293T C170(0.88); C292(0.87)  LDD1061  [16]
 LDCM0464  CL71 HEK-293T C170(0.72); C292(0.91)  LDD1062  [16]
 LDCM0465  CL72 HEK-293T C170(0.79); C292(0.94)  LDD1063  [16]
 LDCM0466  CL73 HEK-293T C170(0.77); C292(0.91)  LDD1064  [16]
 LDCM0467  CL74 HEK-293T C170(0.26); C292(0.97)  LDD1065  [16]
 LDCM0469  CL76 HEK-293T C170(1.25); C292(0.91)  LDD1067  [16]
 LDCM0470  CL77 HEK-293T C170(1.25); C292(0.84)  LDD1068  [16]
 LDCM0471  CL78 HEK-293T C170(2.24); C292(1.68)  LDD1069  [16]
 LDCM0472  CL79 HEK-293T C170(1.28); C292(1.54)  LDD1070  [16]
 LDCM0473  CL8 HEK-293T C170(0.13)  LDD1071  [16]
 LDCM0474  CL80 HEK-293T C170(1.29); C292(1.06)  LDD1072  [16]
 LDCM0475  CL81 HEK-293T C170(1.27); C292(0.88)  LDD1073  [16]
 LDCM0476  CL82 HEK-293T C170(1.03); C292(1.07)  LDD1074  [16]
 LDCM0477  CL83 HEK-293T C170(1.05); C292(0.93)  LDD1075  [16]
 LDCM0478  CL84 HEK-293T C170(1.19); C292(1.03)  LDD1076  [16]
 LDCM0479  CL85 HEK-293T C170(1.36); C292(0.95)  LDD1077  [16]
 LDCM0480  CL86 HEK-293T C170(1.89); C292(1.50)  LDD1078  [16]
 LDCM0481  CL87 HEK-293T C170(1.09); C292(0.97)  LDD1079  [16]
 LDCM0482  CL88 HEK-293T C170(0.86); C292(1.19)  LDD1080  [16]
 LDCM0483  CL89 HEK-293T C170(1.05); C292(0.96)  LDD1081  [16]
 LDCM0484  CL9 HEK-293T C170(0.67)  LDD1082  [16]
 LDCM0485  CL90 HEK-293T C170(0.70); C292(0.80)  LDD1083  [16]
 LDCM0486  CL91 HEK-293T C170(0.99); C292(0.92)  LDD1084  [16]
 LDCM0487  CL92 HEK-293T C170(1.03); C292(0.87)  LDD1085  [16]
 LDCM0488  CL93 HEK-293T C170(0.82); C292(0.87)  LDD1086  [16]
 LDCM0489  CL94 HEK-293T C170(0.59); C292(0.78)  LDD1087  [16]
 LDCM0490  CL95 HEK-293T C170(0.49); C292(0.89)  LDD1088  [16]
 LDCM0491  CL96 HEK-293T C170(0.99); C292(0.87)  LDD1089  [16]
 LDCM0492  CL97 HEK-293T C170(1.15); C292(0.82)  LDD1090  [16]
 LDCM0493  CL98 HEK-293T C170(1.09); C292(1.05)  LDD1091  [16]
 LDCM0494  CL99 HEK-293T C170(1.15); C292(0.93)  LDD1092  [16]
 LDCM0495  E2913 HEK-293T C103(0.96); C170(1.02); C292(1.00); C227(1.27)  LDD1698  [17]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C170(3.21); C227(1.83)  LDD1702  [5]
 LDCM0468  Fragment33 HEK-293T C170(0.16); C292(0.81)  LDD1066  [16]
 LDCM0427  Fragment51 HEK-293T C170(0.48)  LDD1025  [16]
 LDCM0107  IAA HeLa N.A.  LDD0221  [6]
 LDCM0022  KB02 HEK-293T C170(1.09); C292(1.04); C285(1.05)  LDD1492  [17]
 LDCM0023  KB03 HEK-293T C170(1.09); C292(1.09); C285(0.96)  LDD1497  [17]
 LDCM0024  KB05 HMCB C170(1.62); C227(0.96)  LDD3312  [4]
 LDCM0109  NEM HeLa N.A.  LDD0223  [6]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C227(2.02)  LDD2090  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C227(0.58)  LDD2109  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C170(1.00)  LDD2123  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C227(0.78); C170(1.17)  LDD2125  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C227(1.01); C170(0.96)  LDD2127  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C227(0.90); C170(1.39)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C227(0.85); C170(1.09)  LDD2137  [5]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C227(1.83)  LDD1700  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C227(0.54)  LDD2140  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C170(1.51)  LDD2146  [5]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C227(1.78)  LDD2153  [5]

References

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Mass spectrometry data entry: PXD028270
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3 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
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Mass spectrometry data entry: PXD028853
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD029255
13 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
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17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402