Details of the Target

General Information of Target

Target ID LDTP17163
Target Name Zinc finger protein 805 (ZNF805)
Gene Name ZNF805
Gene ID 390980
Synonyms
Zinc finger protein 805
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKMAPQNADPESMQVQELSVPLPDPQKAGGAEAENCETISEGSIDRIPMRLWVMHGAVMF
GREFCYAMETALVTPILLQIGLPEQYYSLTWFLSPILGLIFTPLIGSASDRCTLSWGRRR
PFILALCVGVLFGVALFLNGSAIGLALGDVPNRQPIGIVLTVLGVVVLDFSADATEGPIR
AYLLDVVDSEEQDMALNIHAFSAGLGGAIGYVLGGLDWTQTFLGSWFRTQNQVLFFFAAI
IFTVSVALHLFSIDEEQYSPQQERSAEEPGALDGGEPHGVPAFPDEVQSEHELALDYPDV
DIMRSKSDSALHVPDTALDLEPELLFLHDIEPSIFHDASYPATPRSTSQELAKTKLPRLA
TFLKEAAKEDETLLDNHLNEAKVPNGSGSPTKDALGGYTRVDTKPSATSSSMRRRRHAFR
RQASSTFSYYGKLGSHCYRYRRANAVVLIKPSRSMSDLYDMQKRQRQHRHRNQSGATTSS
GDTESEEGEGETTVRLLWLSMLKMPRELMRLCLCHLLTWFSVIAEAVFYTDFMGQVIFEG
DPKAPSNSTAWQAYNAGVKMGCWGLVIYAATGAICSALLQKYLDNYDLSVRVIYVLGTLG
FSVGTAVMAMFPNVYVAMVTISTMGIVSMSISYCPYALLGQYHDIKQYIHHSPGNSKRGF
GIDCAILSCQVYISQILVASALGGVVDAVGTVRVIPMVASVGSFLGFLTATFLVIYPNVS
EEAKEEQKGLSSPLAGEGRAGGNSEKPTVLKLTRKEGLQGPVETESVV
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q5CZA5
Ensemble ID
ENST00000354309.4
HGNC ID
HGNC:23272

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL51 Deletion: p.S530LfsTer40 .
CASKI SNV: p.A385V .
FADU SNV: p.E207Ter .
ICC10 SNV: p.Y245H .
ICC106 SNV: p.Y245H .
ICC108 SNV: p.Y245H .
LS180 SNV: p.T524A .
LS513 SNV: p.T244K .
NCIH146 SNV: p.R559W .
PC9 SNV: p.G497C .
TOV21G SNV: p.R223M .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C521(0.90)  LDD0547  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C168(0.94)  LDD1507  [2]
 LDCM0230  AC113 HCT 116 C521(0.90)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C521(1.10)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C521(1.38)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C521(1.16)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C521(1.04)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C521(0.99)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C521(1.07)  LDD0553  [1]
 LDCM0237  AC12 HEK-293T C168(0.84)  LDD1510  [2]
 LDCM0238  AC120 HCT 116 C521(1.03)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C521(0.99)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C521(1.08)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C521(1.20)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C521(1.13)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C521(1.00)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C521(1.05)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C521(1.52)  LDD0562  [1]
 LDCM0246  AC128 HCT 116 C521(1.04)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C521(1.07)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C521(1.28)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C521(1.13)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C521(1.60)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C521(1.25)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C521(1.33)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C521(1.36)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C521(1.51)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C521(1.37)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C521(1.44)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C521(1.64)  LDD0575  [1]
 LDCM0260  AC140 HCT 116 C521(1.66)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C521(1.63)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C521(1.21)  LDD0579  [1]
 LDCM0270  AC15 HEK-293T C168(0.84)  LDD1513  [2]
 LDCM0276  AC17 HEK-293T C168(0.98)  LDD1515  [2]
 LDCM0280  AC20 HEK-293T C168(1.01)  LDD1519  [2]
 LDCM0281  AC21 HEK-293T C168(1.03)  LDD1520  [2]
 LDCM0283  AC23 HEK-293T C168(0.92)  LDD1522  [2]
 LDCM0285  AC25 HCT 116 C521(1.19)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C521(1.61)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C521(1.30)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C521(1.51)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C521(1.61)  LDD0606  [1]
 LDCM0291  AC30 HCT 116 C521(1.51)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C521(1.47)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C521(1.75)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C521(1.21)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C521(1.17)  LDD0612  [1]
 LDCM0297  AC36 HEK-293T C168(0.96)  LDD1536  [2]
 LDCM0298  AC37 HEK-293T C168(1.28)  LDD1537  [2]
 LDCM0300  AC39 HEK-293T C168(0.98)  LDD1539  [2]
 LDCM0301  AC4 HEK-293T C168(1.14)  LDD1540  [2]
 LDCM0303  AC41 HEK-293T C168(0.97)  LDD1542  [2]
 LDCM0306  AC44 HEK-293T C168(1.04)  LDD1545  [2]
 LDCM0307  AC45 HEK-293T C168(0.97)  LDD1546  [2]
 LDCM0309  AC47 HEK-293T C168(1.22)  LDD1548  [2]
 LDCM0311  AC49 HEK-293T C168(1.07)  LDD1550  [2]
 LDCM0312  AC5 HEK-293T C168(1.32)  LDD1551  [2]
 LDCM0315  AC52 HEK-293T C168(1.08)  LDD1554  [2]
 LDCM0316  AC53 HEK-293T C168(1.04)  LDD1555  [2]
 LDCM0318  AC55 HEK-293T C168(0.74)  LDD1557  [2]
 LDCM0320  AC57 HEK-293T C168(1.03)  LDD1559  [2]
 LDCM0324  AC60 HEK-293T C168(0.79)  LDD1563  [2]
 LDCM0325  AC61 HEK-293T C168(1.10)  LDD1564  [2]
 LDCM0327  AC63 HEK-293T C168(1.00)  LDD1566  [2]
 LDCM0332  AC68 HCT 116 C521(1.16)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C521(1.10)  LDD0650  [1]
 LDCM0334  AC7 HEK-293T C168(0.93)  LDD1568  [2]
 LDCM0335  AC70 HCT 116 C521(1.14)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C521(1.18)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C521(1.37)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C521(1.61)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C521(1.70)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C521(1.75)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C521(1.33)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C521(1.31)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C521(1.07)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C521(1.27)  LDD0661  [1]
 LDCM0346  AC80 HCT 116 C521(1.32)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C521(1.13)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C521(1.50)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C521(0.76)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C521(0.63)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C521(0.61)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C521(0.73)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C521(0.74)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C521(0.82)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C521(0.68)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C521(0.85)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C521(0.50)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C521(0.67)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C521(0.59)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C521(0.45)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C521(0.67)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C521(0.46)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C521(0.65)  LDD0681  [1]
 LDCM0248  AKOS034007472 HEK-293T C168(0.86)  LDD1511  [2]
 LDCM0356  AKOS034007680 HEK-293T C168(1.30)  LDD1570  [2]
 LDCM0369  CL100 HEK-293T C168(0.90)  LDD1573  [2]
 LDCM0372  CL103 HEK-293T C168(1.07)  LDD1576  [2]
 LDCM0373  CL104 HEK-293T C168(1.06)  LDD1577  [2]
 LDCM0376  CL107 HEK-293T C168(1.11)  LDD1580  [2]
 LDCM0377  CL108 HEK-293T C168(0.74)  LDD1581  [2]
 LDCM0379  CL11 HEK-293T C168(0.83)  LDD1583  [2]
 LDCM0381  CL111 HEK-293T C168(1.02)  LDD1585  [2]
 LDCM0382  CL112 HCT 116 C521(1.24)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C521(1.54)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C521(1.54)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C521(1.37)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C521(1.13)  LDD0703  [1]
 LDCM0389  CL119 HEK-293T C168(1.16)  LDD1593  [2]
 LDCM0391  CL120 HEK-293T C168(0.93)  LDD1595  [2]
 LDCM0394  CL123 HEK-293T C168(0.92)  LDD1598  [2]
 LDCM0395  CL124 HEK-293T C168(1.07)  LDD1599  [2]
 LDCM0398  CL127 HEK-293T C168(1.24)  LDD1602  [2]
 LDCM0399  CL128 HEK-293T C168(0.82)  LDD1603  [2]
 LDCM0402  CL15 HEK-293T C168(1.16)  LDD1606  [2]
 LDCM0403  CL16 HEK-293T C168(0.46)  LDD1607  [2]
 LDCM0404  CL17 HEK-293T C168(1.06)  LDD1608  [2]
 LDCM0408  CL20 HEK-293T C168(0.81)  LDD1612  [2]
 LDCM0409  CL21 HEK-293T C168(1.41)  LDD1613  [2]
 LDCM0411  CL23 HEK-293T C168(0.61)  LDD1615  [2]
 LDCM0415  CL27 HEK-293T C168(1.03)  LDD1619  [2]
 LDCM0416  CL28 HEK-293T C168(0.48)  LDD1620  [2]
 LDCM0417  CL29 HEK-293T C168(0.99)  LDD1621  [2]
 LDCM0418  CL3 HEK-293T C168(1.26)  LDD1622  [2]
 LDCM0421  CL32 HEK-293T C168(0.87)  LDD1625  [2]
 LDCM0422  CL33 HEK-293T C168(1.10)  LDD1626  [2]
 LDCM0424  CL35 HEK-293T C168(0.68)  LDD1628  [2]
 LDCM0428  CL39 HEK-293T C168(0.93)  LDD1632  [2]
 LDCM0429  CL4 HEK-293T C168(0.74)  LDD1633  [2]
 LDCM0430  CL40 HEK-293T C168(0.72)  LDD1634  [2]
 LDCM0431  CL41 HEK-293T C168(0.76)  LDD1635  [2]
 LDCM0434  CL44 HEK-293T C168(1.04)  LDD1638  [2]
 LDCM0435  CL45 HEK-293T C168(1.06)  LDD1639  [2]
 LDCM0436  CL46 HCT 116 C521(1.08)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C521(1.02)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C521(1.28)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C521(0.97)  LDD0756  [1]
 LDCM0440  CL5 HEK-293T C168(0.85)  LDD1644  [2]
 LDCM0441  CL50 HCT 116 C521(1.28)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C521(1.08)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C521(1.07)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C521(1.41)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C521(0.89)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C521(0.88)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C521(0.99)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C521(1.09)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C521(1.01)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C521(1.03)  LDD0767  [1]
 LDCM0452  CL60 HCT 116 C521(1.02)  LDD0769  [1]
 LDCM0453  CL61 HCT 116 C521(1.10)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C521(1.23)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C521(0.98)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C521(1.17)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C521(0.94)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C521(1.08)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C521(1.02)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C521(0.82)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C521(1.29)  LDD0778  [1]
 LDCM0463  CL70 HCT 116 C521(1.00)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C521(1.14)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C521(1.40)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C521(1.22)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C521(1.06)  LDD0784  [1]
 LDCM0469  CL76 HCT 116 C521(0.84)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C521(1.07)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C521(0.97)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C521(0.96)  LDD0789  [1]
 LDCM0473  CL8 HEK-293T C168(0.78)  LDD1676  [2]
 LDCM0474  CL80 HCT 116 C521(0.91)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C521(1.04)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C521(1.32)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C521(0.91)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C521(1.00)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C521(0.81)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C521(0.84)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C521(0.76)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C521(0.81)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C521(0.78)  LDD0800  [1]
 LDCM0484  CL9 HEK-293T C168(1.28)  LDD1687  [2]
 LDCM0485  CL90 HCT 116 C521(1.19)  LDD0802  [1]
 LDCM0487  CL92 HEK-293T C168(1.15)  LDD1690  [2]
 LDCM0488  CL93 HEK-293T C168(1.19)  LDD1691  [2]
 LDCM0490  CL95 HEK-293T C168(1.25)  LDD1693  [2]
 LDCM0494  CL99 HEK-293T C168(1.43)  LDD1697  [2]
 LDCM0495  E2913 HEK-293T C168(1.30)  LDD1698  [2]
 LDCM0468  Fragment33 HCT 116 C521(1.08)  LDD0785  [1]
 LDCM0022  KB02 HEK-293T C168(0.48)  LDD1492  [2]
 LDCM0023  KB03 HEK-293T C168(1.24)  LDD1497  [2]
 LDCM0024  KB05 MEWO C35(1.04)  LDD3319  [3]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840