Details of the Target

General Information of Target

Target ID LDTP17151
Target Name Keratinocyte-associated protein 3 (KRTCAP3)
Gene Name KRTCAP3
Gene ID 200634
Synonyms
KCP3; Keratinocyte-associated protein 3; KCP-3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNLNPPTSALQIEGKGSHIMARNVSCFLVRHTPHPRRVCHIKGLNNIPICTVNDDENAFG
TLWGVGQSNYLEKNRIPFANCSYPSSTAVQESPVRGMSPAPNGAKVPPRPHSEPSRKIKE
CFKTSSENPLVIKKEEIKAKRPPSPPKACSTPGSCSSGMTSTKNDVKANTICIPNYLDQE
IKILAKLCSILHTDSLAEVLQWLLHATSKEKEWVSALIHSELAEINLLTHHRRNTSMEPA
AETGKPPTVKSPPTVKLPPNFTAKSKVLTRDTEGDQPTRVSSQGSEENKEVPKEAEHKPP
LLIRRNNMKIPVAEYFSKPNSPPRPNTQESGSAKPVSARSIQEYNLCPQRACYPSTHRR
Target Bioclass
Other
Family
TMEM54 family
Subcellular location
Membrane
Uniprot ID
Q53RY4
Ensemble ID
ENST00000288873.7
HGNC ID
HGNC:28943

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2058 SNV: p.P89L .
JURKAT SNV: p.A12T .
KURAMOCHI SNV: p.V60L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C132(1.14); C152(1.14)  LDD0532  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HCT 116 C132(1.14); C152(1.14)  LDD0532  [1]
 LDCM0226  AC11 HCT 116 C132(1.07); C152(1.07)  LDD0543  [1]
 LDCM0230  AC113 HCT 116 C132(0.51); C152(0.51)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C132(0.76); C152(0.76)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C132(0.75); C152(0.75)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C132(0.84); C152(0.84)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C132(0.63); C152(0.63)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C132(0.77); C152(0.77)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C132(0.98); C152(0.98)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C132(1.00); C152(1.00)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C132(0.58); C152(0.58)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C132(0.47); C152(0.47)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C132(0.59); C152(0.59)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C132(0.91); C152(0.91)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C132(0.69); C152(0.69)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C132(0.62); C152(0.62)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C132(0.62); C152(0.62)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C132(0.83); C152(0.83)  LDD0562  [1]
 LDCM0246  AC128 HCT 116 C132(1.26); C152(1.26)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C132(1.16); C152(1.16)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C132(1.21); C152(1.21)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C132(0.98); C152(0.98)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C132(0.97); C152(0.97)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C132(0.90); C152(0.90)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C132(1.14); C152(1.14)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C132(1.15); C152(1.15)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C132(1.47); C152(1.47)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C132(1.57); C152(1.57)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C132(1.04); C152(1.04)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C132(0.89); C152(0.89)  LDD0575  [1]
 LDCM0259  AC14 HCT 116 C132(1.54); C152(1.54)  LDD0576  [1]
 LDCM0260  AC140 HCT 116 C132(1.18); C152(1.18)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C132(1.00); C152(1.00)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C132(0.72); C152(0.72)  LDD0579  [1]
 LDCM0263  AC143 HCT 116 C132(0.93); C152(0.93)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C132(1.09); C152(1.09)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C132(1.04); C152(1.04)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C132(1.15); C152(1.15)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C132(0.97); C152(0.97)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C132(1.38); C152(1.38)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C132(1.25); C152(1.25)  LDD0586  [1]
 LDCM0270  AC15 HCT 116 C132(1.27); C152(1.27)  LDD0587  [1]
 LDCM0271  AC150 HCT 116 C132(1.14); C152(1.14)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C132(0.95); C152(0.95)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C132(1.32); C152(1.32)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C132(1.25); C152(1.25)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C132(1.40); C152(1.40)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C132(1.36); C152(1.36)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C132(1.10); C152(1.10)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C132(1.06); C152(1.06)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C132(1.26); C152(1.26)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C132(0.82); C152(0.82)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C132(1.00); C152(1.00)  LDD0595  [1]
 LDCM0280  AC20 HCT 116 C132(0.87); C152(0.87)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C132(0.62); C152(0.62)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C132(0.82); C152(0.82)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C132(0.70); C152(0.70)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C132(0.69); C152(0.69)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C132(0.85); C152(0.85)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C132(0.85); C152(0.85)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C132(0.85); C152(0.85)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C132(1.17); C152(1.17)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C132(1.08); C152(1.08)  LDD0606  [1]
 LDCM0291  AC30 HCT 116 C132(0.95); C152(0.95)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C132(0.91); C152(0.91)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C132(0.97); C152(0.97)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C132(1.30); C152(1.30)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C132(0.78); C152(0.78)  LDD0612  [1]
 LDCM0323  AC6 HCT 116 C132(1.24); C152(1.24)  LDD0640  [1]
 LDCM0334  AC7 HCT 116 C132(1.01); C152(1.01)  LDD0651  [1]
 LDCM0345  AC8 HCT 116 C132(0.91); C152(0.91)  LDD0662  [1]
 LDCM0349  AC83 HCT 116 C132(1.01); C152(1.01)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C132(1.06); C152(1.06)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C132(0.97); C152(0.97)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C132(1.01); C152(1.01)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C132(0.96); C152(0.96)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C132(0.88); C152(0.88)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C132(1.07); C152(1.07)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C132(0.82); C152(0.82)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C132(0.89); C152(0.89)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C132(0.90); C152(0.90)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C132(1.01); C152(1.01)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C132(1.10); C152(1.10)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C132(1.07); C152(1.07)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C132(0.94); C152(0.94)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C132(1.27); C152(1.27)  LDD0681  [1]
 LDCM0248  AKOS034007472 HCT 116 C132(0.91); C152(0.91)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C132(1.02); C152(1.02)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C132(1.43); C152(1.43)  LDD0592  [1]
 LDCM0370  CL101 HCT 116 C132(1.40); C152(1.40)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C132(0.95); C152(0.95)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C132(1.43); C152(1.43)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C132(0.96); C152(0.96)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C132(0.78); C152(0.78)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C132(1.09); C152(1.09)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C132(0.98); C152(0.98)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C132(1.45); C152(1.45)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C132(0.94); C152(0.94)  LDD0695  [1]
 LDCM0380  CL110 HCT 116 C132(1.40); C152(1.40)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C132(1.16); C152(1.16)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C132(0.99); C152(0.99)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C132(0.77); C152(0.77)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C132(1.13); C152(1.13)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C132(1.28); C152(1.28)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C132(0.79); C152(0.79)  LDD0703  [1]
 LDCM0420  CL31 HCT 116 C132(1.54); C152(1.54)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C132(0.98); C152(0.98)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C132(1.89); C152(1.89)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C132(1.83); C152(1.83)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C132(1.55); C152(1.55)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C132(1.36); C152(1.36)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C132(1.25); C152(1.25)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C132(1.36); C152(1.36)  LDD0745  [1]
 LDCM0430  CL40 HCT 116 C132(1.37); C152(1.37)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C132(1.28); C152(1.28)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C132(1.51); C152(1.51)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C132(0.98); C152(0.98)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C132(1.53); C152(1.53)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C132(1.35); C152(1.35)  LDD0752  [1]
 LDCM0427  Fragment51 HCT 116 C132(1.47); C152(1.47)  LDD0744  [1]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.