Details of the Target

General Information of Target

Target ID LDTP16179
Target Name Ubiquitin carboxyl-terminal hydrolase 35 (USP35)
Gene Name USP35
Gene ID 57558
Synonyms
KIAA1372; USP34; Ubiquitin carboxyl-terminal hydrolase 35; EC 3.4.19.12; Deubiquitinating enzyme 35; Ubiquitin thioesterase 35; Ubiquitin-specific-processing protease 35
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSDPRQSQEEKHKLGRASSKFKDPPRIMQSDDYFARKFKAINGNMGPTTSLNASNSNETG
GGGPANGTPAVPKMGVRARVSEWPPKKDCSKELTCKALWESRSQTSYESITSVLQNGQSD
QSEGQQDEQLDLDFVEAKYTIGDIFVHSPQRGLHPIRQRSNSDVTISDIDAEDVLDQNAV
NPNTGAALHREYGSTSSIDRQGLSGENFFAMLRGYRVENYDHKAMVPFGFPEFFRCDPAI
SPSLHAAAQISRGEFVRISGLDYVDSALLMGRDRDKPFKRRLKSESVETSLFRKLRTVKS
EHETFKFTSELEESRLERGIRPWNCQRCFAHYDVQSILFNINEAMATRANVGKRKNITTG
ASAASQTQMPTGQTGNCESPLGSKEDLNSKENLDADEGDGKSNDLVLSCPYFRNETGGEG
DRRIALSRANSSSFSSGESCSFESSLSSHCTNAGVSVLEVPRENQPIHREKVKRYIIEHI
DLGAYYYRKFFYGKEHQNYFGIDENLGPVAVSIRREKVEDAKEKEGSQFNYRVAFRTSEL
TTLRGAILEDAIPSTARHGTARGLPLKEVLEYVIPELSIQCLRQASNSPKVSEQLLKLDE
QGLSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDNK
TDSTGTHSLYTTYKDYELMFHVSTLLPYMPNNRQQLLRKRHIGNDIVTIVFQEPGALPFT
PKSIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGVTFPKSAVFRDFL
LAKVINAENAAHKSEKFRAMATRTRQEYLKDLAENFVTTATVDTSVKFSFITLGAKKKEK
VKPRKDAHLFSIGAIMWHVIARDFGQSADIECLLGISNEFIMLIEKDSKNVVFNCSCRDV
IGWTSGLVSIKVFYERGECVLLSSVDNCAEDIREIVQRLVIVTRGCETVEMTLRRNGLGQ
LGFHVNFEGIVADVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRTSVTVKVV
IIQPHDDGSPRRGCSELCRIPMVEYKLDSEGTPCEYKTPFRRNTTWHRVPTPALQPLSRA
SPIPGTPDRLPCQQLLQQAQAAIPRSTSFDRKLPDGTRSSPSNQSSSSDPGPGGSGPWRP
QVGYDGCQSPLLLEHQGSGPLECDGAREREDTMEASRHPETKWHGPPSKVLGSYKERALQ
KDGSCKDSPNKLSHIGDKSCSSHSSSNTLSSNTSSNSDDKHFGSGDLMDPELLGLTYIKG
ASTDSGIDTAPCMPATILGPVHLAGSRSLIHSRAEQWADAADVSGPDDEPAKLYSVHGYA
STISAGSAAEGSMGDLSEISSHSSGSHHSGSPSAHCSKSSGSLDSSKVYIVSHSSGQQVP
GSMSKPYHRQGAVNKYVIGWKKSEGSPPPEEPEVTECPGMYSEMDVMSTATQHQTVVGDA
VAETQHVLSKEDFLKLMLPDSPLVEEGRRKFSFYGNLSPRRSLYRTLSDESICSNRRGSS
FGSSRSSVLDQALPNDILFSTTPPYHSTLPPRAHPAPSMGSLRNEFWFSDGSLSDKSKCA
DPGLMPLPDTATGLDWTHLVDAARAFEGLDSDEELGLLCHHTSYLDQRVASFCTLTDMQH
GQDLEGAQELPLCVDPGSGKEFMDTTGERSPSPLTGKVNQLELILRQLQTDLRKEKQDKA
VLQAEVQHLRQDNMRLQEESQTATAQLRKFTEWFFTTIDKKS
Target Bioclass
Enzyme
Family
Peptidase C19 family
Function
Deubiquitinase that plays a role in different processes including cell cycle regulation, mitophagy or endoplasmic reticulum stress. Inhibits TNFalpha-induced NF-kappa-B activation through stabilizing TNIP2 protein via deubiquitination. Plays an essential role during mitosis by deubiquitinating and thereby regulating the levels of Aurora B/AURKB protein. In addition, regulates the protein levels of other key component of the chromosomal passenger complex (CPC) such as survivin/BIRC5 or Borealin/CDCA8 by enhancing their stability. Regulates the degradation of mitochondria through the process of autophagy termed mitophagy.
Uniprot ID
Q9P2H5
Ensemble ID
ENST00000526425.1
HGNC ID
HGNC:20061
ChEMBL ID
CHEMBL4630862

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.A142T .
CMK SNV: p.L491V .
COLO829 SNV: p.V104A DBIA    Probe Info 
DU145 SNV: p.K297M .
HEC1B SNV: p.G51D .
JURKAT SNV: p.Q729K .
KMCH1 SNV: p.Q495P .
KP4 SNV: p.A498D .
LN18 SNV: p.C450G .
MEC1 SNV: p.K718N .
NCIH446 SNV: p.H72Y .
NCIN87 SNV: p.E55Q .
RKO SNV: p.K718N .
SNGM SNV: p.T538M .
SW620 SNV: p.G324V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C62(20.00)  LDD1705  [1]
Acrolein
 Probe Info  		N.A.  LDD0222  [2]
DBIA
 Probe Info  		C785(1.09)  LDD0812  [3]
NAIA_5
 Probe Info  		N.A.  LDD2225  [4]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [2]
Methacrolein
 Probe Info  		N.A.  LDD0218  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C785(1.09)  LDD0812  [3]
 LDCM0215  AC10 HEK-293T C133(1.43); C141(1.12)  LDD0813  [3]
 LDCM0216  AC100 HEK-293T C133(1.36); C141(1.36); C62(1.19)  LDD0814  [3]
 LDCM0217  AC101 HEK-293T C133(1.10); C141(1.10); C62(1.14)  LDD0815  [3]
 LDCM0218  AC102 HEK-293T C133(1.34); C141(1.34); C62(1.15)  LDD0816  [3]
 LDCM0219  AC103 HEK-293T C133(1.28); C141(1.28); C62(1.38)  LDD0817  [3]
 LDCM0220  AC104 HEK-293T C133(1.72); C141(1.72); C62(1.31)  LDD0818  [3]
 LDCM0221  AC105 HEK-293T C133(1.16); C141(1.16); C62(0.97)  LDD0819  [3]
 LDCM0222  AC106 HEK-293T C133(1.20); C141(1.20); C62(0.77)  LDD0820  [3]
 LDCM0223  AC107 HEK-293T C133(1.43); C141(1.43); C62(1.10)  LDD0821  [3]
 LDCM0224  AC108 HEK-293T C133(1.05); C141(1.05); C62(0.92)  LDD0822  [3]
 LDCM0225  AC109 HEK-293T C133(1.13); C141(1.13); C62(0.95)  LDD0823  [3]
 LDCM0226  AC11 HEK-293T C133(1.37); C141(0.97)  LDD0824  [3]
 LDCM0227  AC110 HEK-293T C133(0.99); C141(0.99); C62(2.32)  LDD0825  [3]
 LDCM0228  AC111 HEK-293T C133(1.18); C141(1.18); C62(3.00)  LDD0826  [3]
 LDCM0229  AC112 HEK-293T C133(1.46); C141(1.46); C62(2.64)  LDD0827  [3]
 LDCM0230  AC113 HEK-293T C62(0.93)  LDD0828  [3]
 LDCM0231  AC114 HEK-293T C62(0.99)  LDD0829  [3]
 LDCM0232  AC115 HEK-293T C62(1.00)  LDD0830  [3]
 LDCM0233  AC116 HEK-293T C62(1.38)  LDD0831  [3]
 LDCM0234  AC117 HEK-293T C62(1.17)  LDD0832  [3]
 LDCM0235  AC118 HEK-293T C62(1.26)  LDD0833  [3]
 LDCM0236  AC119 HEK-293T C62(1.57)  LDD0834  [3]
 LDCM0237  AC12 HEK-293T C133(1.19); C141(0.91)  LDD0835  [3]
 LDCM0238  AC120 HEK-293T C62(1.25)  LDD0836  [3]
 LDCM0239  AC121 HEK-293T C62(1.23)  LDD0837  [3]
 LDCM0240  AC122 HEK-293T C62(1.68)  LDD0838  [3]
 LDCM0241  AC123 HEK-293T C62(1.73)  LDD0839  [3]
 LDCM0242  AC124 HEK-293T C62(1.28)  LDD0840  [3]
 LDCM0243  AC125 HEK-293T C62(1.68)  LDD0841  [3]
 LDCM0244  AC126 HEK-293T C62(2.40)  LDD0842  [3]
 LDCM0245  AC127 HEK-293T C62(2.75)  LDD0843  [3]
 LDCM0246  AC128 HEK-293T C133(1.18); C141(1.18); C62(0.89); C785(0.96)  LDD0844  [3]
 LDCM0247  AC129 HEK-293T C133(1.45); C141(1.45); C62(1.30); C785(1.30)  LDD0845  [3]
 LDCM0249  AC130 HEK-293T C133(1.27); C141(1.27); C62(1.21); C785(1.42)  LDD0847  [3]
 LDCM0250  AC131 HEK-293T C133(1.00); C141(1.00); C62(1.02); C785(1.17)  LDD0848  [3]
 LDCM0251  AC132 HEK-293T C133(1.54); C141(1.54); C62(1.14); C785(1.28)  LDD0849  [3]
 LDCM0252  AC133 HEK-293T C133(1.04); C141(1.04); C62(1.59); C785(1.62)  LDD0850  [3]
 LDCM0253  AC134 HEK-293T C133(1.53); C141(1.53); C62(1.39); C785(1.39)  LDD0851  [3]
 LDCM0254  AC135 HEK-293T C133(1.25); C141(1.25); C62(1.37); C785(1.29)  LDD0852  [3]
 LDCM0255  AC136 HEK-293T C133(1.37); C141(1.37); C62(1.29); C785(1.63)  LDD0853  [3]
 LDCM0256  AC137 HEK-293T C133(1.29); C141(1.29); C62(1.92); C785(1.75)  LDD0854  [3]
 LDCM0257  AC138 HEK-293T C133(1.42); C141(1.42); C62(2.32); C785(2.30)  LDD0855  [3]
 LDCM0258  AC139 HEK-293T C133(1.00); C141(1.00); C62(1.99); C785(1.66)  LDD0856  [3]
 LDCM0259  AC14 HEK-293T C133(1.42); C141(1.02)  LDD0857  [3]
 LDCM0260  AC140 HEK-293T C133(1.04); C141(1.04); C62(1.50); C785(2.08)  LDD0858  [3]
 LDCM0261  AC141 HEK-293T C133(1.04); C141(1.04); C62(2.07); C785(1.65)  LDD0859  [3]
 LDCM0262  AC142 HEK-293T C133(1.23); C141(1.23); C62(1.54); C785(1.24)  LDD0860  [3]
 LDCM0263  AC143 HEK-293T C133(1.18); C141(1.18); C62(1.06); C785(1.23)  LDD0861  [3]
 LDCM0264  AC144 HEK-293T C133(1.16); C141(1.16); C62(1.84); C785(1.59)  LDD0862  [3]
 LDCM0265  AC145 HEK-293T C133(0.91); C141(0.91); C62(1.83); C785(1.56)  LDD0863  [3]
 LDCM0266  AC146 HEK-293T C133(0.80); C141(0.80); C62(1.94); C785(1.69)  LDD0864  [3]
 LDCM0267  AC147 HEK-293T C133(1.26); C141(1.26); C62(1.88); C785(1.77)  LDD0865  [3]
 LDCM0268  AC148 HEK-293T C133(0.82); C141(0.82); C62(1.47); C785(2.13)  LDD0866  [3]
 LDCM0269  AC149 HEK-293T C133(0.85); C141(0.85); C62(1.20); C785(1.15)  LDD0867  [3]
 LDCM0270  AC15 HEK-293T C133(1.39); C141(0.89)  LDD0868  [3]
 LDCM0271  AC150 HEK-293T C133(0.89); C141(0.89); C62(1.09); C785(1.42)  LDD0869  [3]
 LDCM0272  AC151 HEK-293T C133(0.81); C141(0.81); C62(1.56); C785(1.60)  LDD0870  [3]
 LDCM0273  AC152 HEK-293T C133(1.01); C141(1.01); C62(1.18); C785(1.67)  LDD0871  [3]
 LDCM0274  AC153 HEK-293T C133(0.91); C141(0.91); C62(1.18); C785(1.33)  LDD0872  [3]
 LDCM0621  AC154 HEK-293T C133(1.55); C141(1.55); C62(1.27); C785(1.07)  LDD2162  [3]
 LDCM0622  AC155 HEK-293T C133(0.91); C141(0.91); C62(1.27); C785(1.29)  LDD2163  [3]
 LDCM0623  AC156 HEK-293T C133(0.93); C141(0.93); C62(1.73); C785(2.34)  LDD2164  [3]
 LDCM0624  AC157 HEK-293T C133(1.08); C141(1.08); C62(2.54); C785(2.49)  LDD2165  [3]
 LDCM0276  AC17 HEK-293T C141(1.42); C62(1.43)  LDD0874  [3]
 LDCM0277  AC18 HEK-293T C141(1.93); C62(1.26)  LDD0875  [3]
 LDCM0278  AC19 HEK-293T C141(1.19); C62(1.18)  LDD0876  [3]
 LDCM0279  AC2 HEK-293T C785(1.17)  LDD0877  [3]
 LDCM0280  AC20 HEK-293T C141(1.67); C62(1.41)  LDD0878  [3]
 LDCM0281  AC21 HEK-293T C141(1.06); C62(1.11)  LDD0879  [3]
 LDCM0282  AC22 HEK-293T C141(1.22); C62(1.36)  LDD0880  [3]
 LDCM0283  AC23 HEK-293T C141(1.20); C62(1.52)  LDD0881  [3]
 LDCM0284  AC24 HEK-293T C141(1.15); C62(1.41)  LDD0882  [3]
 LDCM0285  AC25 HEK-293T C133(0.76); C141(0.76); C62(1.29); C785(1.28)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C133(1.02); C141(1.02); C62(1.43); C785(1.37)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C133(0.82); C141(0.82); C62(1.21); C785(1.09)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C133(0.86); C141(0.86); C62(1.23); C785(1.36)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C133(0.72); C141(0.72); C62(1.35); C785(1.26)  LDD0887  [3]
 LDCM0290  AC3 HEK-293T C785(1.16)  LDD0888  [3]
 LDCM0291  AC30 HEK-293T C133(0.81); C141(0.81); C62(1.32); C785(1.18)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C133(0.70); C141(0.70); C62(1.06); C785(0.93)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C133(0.89); C141(0.89); C62(1.36); C785(1.15)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C133(0.98); C141(0.98); C62(1.31); C785(1.19)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C133(0.94); C141(0.94); C62(1.33); C785(1.20)  LDD0893  [3]
 LDCM0296  AC35 HEK-293T C133(1.02); C141(1.02); C62(0.79)  LDD0894  [3]
 LDCM0297  AC36 HEK-293T C133(0.99); C141(0.99); C62(0.92)  LDD0895  [3]
 LDCM0298  AC37 HEK-293T C133(0.96); C141(0.96); C62(0.95)  LDD0896  [3]
 LDCM0299  AC38 HEK-293T C133(0.66); C141(0.66); C62(0.95)  LDD0897  [3]
 LDCM0300  AC39 HEK-293T C133(1.45); C141(1.45); C62(0.90)  LDD0898  [3]
 LDCM0301  AC4 HEK-293T C785(1.26)  LDD0899  [3]
 LDCM0302  AC40 HEK-293T C133(0.88); C141(0.88); C62(1.03)  LDD0900  [3]
 LDCM0303  AC41 HEK-293T C133(0.99); C141(0.99); C62(1.02)  LDD0901  [3]
 LDCM0304  AC42 HEK-293T C133(0.68); C141(0.68); C62(1.09)  LDD0902  [3]
 LDCM0305  AC43 HEK-293T C133(0.83); C141(0.83); C62(1.08)  LDD0903  [3]
 LDCM0306  AC44 HEK-293T C133(0.98); C141(0.98); C62(1.08)  LDD0904  [3]
 LDCM0307  AC45 HEK-293T C133(1.55); C141(1.55); C62(0.99)  LDD0905  [3]
 LDCM0308  AC46 HEK-293T C133(0.97); C141(0.97); C62(0.76); C785(1.18)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C133(0.85); C141(0.85); C62(0.93); C785(1.32)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C133(0.89); C141(0.89); C62(1.24); C785(1.30)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C133(1.03); C141(1.03); C62(0.96); C785(1.30)  LDD0909  [3]
 LDCM0312  AC5 HEK-293T C785(1.12)  LDD0910  [3]
 LDCM0313  AC50 HEK-293T C133(1.22); C141(1.22); C62(1.06); C785(1.17)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C133(1.31); C141(1.31); C62(1.10); C785(1.42)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C133(0.80); C141(0.80); C62(1.37); C785(1.46)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C133(1.31); C141(1.31); C62(1.21); C785(1.17)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C133(1.00); C141(1.00); C62(1.14); C785(1.40)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C133(1.16); C141(1.16); C62(1.07); C785(1.24)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C133(0.87); C141(0.87); C62(1.04); C785(1.28)  LDD0917  [3]
 LDCM0320  AC57 HEK-293T C133(1.34); C141(1.21); C785(1.00)  LDD0918  [3]
 LDCM0321  AC58 HEK-293T C133(0.89); C141(0.91); C785(1.00)  LDD0919  [3]
 LDCM0322  AC59 HEK-293T C133(1.27); C141(1.10); C785(0.84)  LDD0920  [3]
 LDCM0323  AC6 HEK-293T C133(1.59); C141(0.82)  LDD0921  [3]
 LDCM0324  AC60 HEK-293T C133(1.09); C141(0.94); C785(0.75)  LDD0922  [3]
 LDCM0325  AC61 HEK-293T C133(1.43); C141(1.18); C785(1.10)  LDD0923  [3]
 LDCM0326  AC62 HEK-293T C133(1.16); C141(1.02); C785(1.13)  LDD0924  [3]
 LDCM0327  AC63 HEK-293T C133(1.26); C141(1.09); C785(1.11)  LDD0925  [3]
 LDCM0328  AC64 HEK-293T C133(1.07); C141(0.95); C785(0.83)  LDD0926  [3]
 LDCM0329  AC65 HEK-293T C133(1.48); C141(1.23); C785(1.03)  LDD0927  [3]
 LDCM0330  AC66 HEK-293T C133(1.18); C141(1.09); C785(0.89)  LDD0928  [3]
 LDCM0331  AC67 HEK-293T C133(1.26); C141(1.09); C785(0.99)  LDD0929  [3]
 LDCM0332  AC68 HEK-293T C133(1.11); C141(1.22); C62(1.03); C785(1.06)  LDD0930  [3]
 LDCM0333  AC69 HEK-293T C133(0.97); C141(1.02); C62(1.17); C785(1.17)  LDD0931  [3]
 LDCM0334  AC7 HEK-293T C133(1.28); C141(0.89)  LDD0932  [3]
 LDCM0335  AC70 HEK-293T C133(1.16); C141(1.35); C62(1.32); C785(1.22)  LDD0933  [3]
 LDCM0336  AC71 HEK-293T C133(1.15); C141(1.27); C62(1.15); C785(1.13)  LDD0934  [3]
 LDCM0337  AC72 HEK-293T C133(0.85); C141(0.74); C62(1.15); C785(1.21)  LDD0935  [3]
 LDCM0338  AC73 HEK-293T C133(0.93); C141(1.00); C62(1.14); C785(1.26)  LDD0936  [3]
 LDCM0339  AC74 HEK-293T C133(1.09); C141(1.46); C62(1.27); C785(1.31)  LDD0937  [3]
 LDCM0340  AC75 HEK-293T C133(0.90); C141(0.80); C62(1.43); C785(1.35)  LDD0938  [3]
 LDCM0341  AC76 HEK-293T C133(0.86); C141(0.84); C62(1.21); C785(1.09)  LDD0939  [3]
 LDCM0342  AC77 HEK-293T C133(1.11); C141(1.28); C62(1.24); C785(1.24)  LDD0940  [3]
 LDCM0343  AC78 HEK-293T C133(0.86); C141(0.82); C62(1.31); C785(1.20)  LDD0941  [3]
 LDCM0344  AC79 HEK-293T C133(1.05); C141(1.07); C62(1.14); C785(1.10)  LDD0942  [3]
 LDCM0345  AC8 HEK-293T C133(1.34); C141(1.36)  LDD0943  [3]
 LDCM0346  AC80 HEK-293T C133(1.06); C141(1.23); C62(1.40); C785(1.35)  LDD0944  [3]
 LDCM0347  AC81 HEK-293T C133(1.24); C141(1.49); C62(1.35); C785(1.29)  LDD0945  [3]
 LDCM0348  AC82 HEK-293T C133(0.97); C141(1.13); C62(1.93); C785(1.60)  LDD0946  [3]
 LDCM0349  AC83 HEK-293T C133(1.29); C141(1.29); C62(1.07); C785(1.07)  LDD0947  [3]
 LDCM0350  AC84 HEK-293T C133(0.63); C141(0.63); C62(1.32); C785(1.49)  LDD0948  [3]
 LDCM0351  AC85 HEK-293T C133(0.60); C141(0.60); C62(1.43); C785(1.36)  LDD0949  [3]
 LDCM0352  AC86 HEK-293T C133(1.26); C141(1.26); C62(1.11); C785(1.11)  LDD0950  [3]
 LDCM0353  AC87 HEK-293T C133(0.76); C141(0.76); C62(1.17); C785(1.31)  LDD0951  [3]
 LDCM0354  AC88 HEK-293T C133(0.63); C141(0.63); C62(1.36); C785(1.31)  LDD0952  [3]
 LDCM0355  AC89 HEK-293T C133(0.93); C141(0.93); C62(1.40); C785(1.42)  LDD0953  [3]
 LDCM0357  AC90 HEK-293T C133(0.76); C141(0.76); C62(1.48); C785(1.31)  LDD0955  [3]
 LDCM0358  AC91 HEK-293T C133(1.12); C141(1.12); C62(1.24); C785(1.37)  LDD0956  [3]
 LDCM0359  AC92 HEK-293T C133(0.89); C141(0.89); C62(1.07); C785(1.32)  LDD0957  [3]
 LDCM0360  AC93 HEK-293T C133(0.64); C141(0.64); C62(1.30); C785(1.41)  LDD0958  [3]
 LDCM0361  AC94 HEK-293T C133(0.83); C141(0.83); C62(1.55); C785(1.43)  LDD0959  [3]
 LDCM0362  AC95 HEK-293T C133(0.83); C141(0.83); C62(1.61); C785(1.35)  LDD0960  [3]
 LDCM0363  AC96 HEK-293T C133(0.78); C141(0.78); C62(1.45); C785(1.43)  LDD0961  [3]
 LDCM0364  AC97 HEK-293T C133(0.83); C141(0.83); C62(3.86); C785(3.04)  LDD0962  [3]
 LDCM0365  AC98 HEK-293T C133(0.95); C141(0.95); C62(0.89)  LDD0963  [3]
 LDCM0366  AC99 HEK-293T C133(1.20); C141(1.20); C62(0.85)  LDD0964  [3]
 LDCM0248  AKOS034007472 HEK-293T C133(1.25); C141(1.00)  LDD0846  [3]
 LDCM0356  AKOS034007680 HEK-293T C133(1.23); C141(1.01)  LDD0954  [3]
 LDCM0275  AKOS034007705 HEK-293T C133(1.22); C141(1.06)  LDD0873  [3]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [2]
 LDCM0369  CL100 HEK-293T C785(1.57)  LDD0967  [3]
 LDCM0370  CL101 HEK-293T C133(1.25); C141(1.01)  LDD0968  [3]
 LDCM0371  CL102 HEK-293T C133(1.39); C141(1.15)  LDD0969  [3]
 LDCM0372  CL103 HEK-293T C133(1.17); C141(1.46)  LDD0970  [3]
 LDCM0373  CL104 HEK-293T C133(1.37); C141(1.05)  LDD0971  [3]
 LDCM0374  CL105 HEK-293T C141(1.07); C62(1.44)  LDD0972  [3]
 LDCM0375  CL106 HEK-293T C141(1.48); C62(1.22)  LDD0973  [3]
 LDCM0376  CL107 HEK-293T C141(1.39); C62(1.03)  LDD0974  [3]
 LDCM0377  CL108 HEK-293T C141(1.23); C62(1.46)  LDD0975  [3]
 LDCM0378  CL109 HEK-293T C141(1.07); C62(1.38)  LDD0976  [3]
 LDCM0380  CL110 HEK-293T C141(1.65); C62(1.66)  LDD0978  [3]
 LDCM0381  CL111 HEK-293T C141(1.29); C62(1.43)  LDD0979  [3]
 LDCM0382  CL112 HEK-293T C133(0.89); C141(0.89); C62(1.75); C785(1.14)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C133(1.01); C141(1.01); C62(1.27); C785(1.19)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C133(0.65); C141(0.65); C62(2.35); C785(1.70)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C133(0.71); C141(0.71); C62(1.56); C785(1.28)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C133(1.21); C141(1.21); C62(1.65); C785(1.34)  LDD0984  [3]
 LDCM0387  CL117 HEK-293T C133(1.16); C141(1.16); C62(0.89)  LDD0985  [3]
 LDCM0388  CL118 HEK-293T C133(0.88); C141(0.88); C62(0.82)  LDD0986  [3]
 LDCM0389  CL119 HEK-293T C133(0.87); C141(0.87); C62(1.13)  LDD0987  [3]
 LDCM0391  CL120 HEK-293T C133(1.11); C141(1.11); C62(1.00)  LDD0989  [3]
 LDCM0392  CL121 HEK-293T C133(0.90); C141(0.90); C62(0.94); C785(1.32)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C133(1.23); C141(1.23); C62(0.99); C785(1.35)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C133(0.87); C141(0.87); C62(0.89); C785(1.07)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C133(1.23); C141(1.23); C62(1.02); C785(1.18)  LDD0993  [3]
 LDCM0396  CL125 HEK-293T C133(1.46); C141(1.25); C785(0.83)  LDD0994  [3]
 LDCM0397  CL126 HEK-293T C133(0.92); C141(0.97); C785(1.08)  LDD0995  [3]
 LDCM0398  CL127 HEK-293T C133(0.78); C141(0.88); C785(1.01)  LDD0996  [3]
 LDCM0399  CL128 HEK-293T C133(0.97); C141(0.93); C785(0.85)  LDD0997  [3]
 LDCM0403  CL16 HEK-293T C133(0.98); C62(1.36); C785(0.96)  LDD1001  [3]
 LDCM0404  CL17 HEK-293T C133(0.90); C62(3.04); C785(0.96)  LDD1002  [3]
 LDCM0405  CL18 HEK-293T C133(0.94); C62(1.48); C785(1.15)  LDD1003  [3]
 LDCM0406  CL19 HEK-293T C133(0.86); C62(1.46); C785(0.98)  LDD1004  [3]
 LDCM0408  CL20 HEK-293T C133(0.95); C62(1.32); C785(1.02)  LDD1006  [3]
 LDCM0409  CL21 HEK-293T C133(0.76); C62(1.69); C785(1.19)  LDD1007  [3]
 LDCM0410  CL22 HEK-293T C133(0.91); C62(1.52); C785(1.06)  LDD1008  [3]
 LDCM0411  CL23 HEK-293T C133(0.99); C62(1.03); C785(0.94)  LDD1009  [3]
 LDCM0412  CL24 HEK-293T C133(0.93); C62(1.32); C785(1.01)  LDD1010  [3]
 LDCM0413  CL25 HEK-293T C133(1.04); C62(1.80); C785(1.12)  LDD1011  [3]
 LDCM0414  CL26 HEK-293T C133(0.60); C62(1.14); C785(1.12)  LDD1012  [3]
 LDCM0415  CL27 HEK-293T C133(0.92); C62(1.07); C785(1.05)  LDD1013  [3]
 LDCM0416  CL28 HEK-293T C133(0.95); C62(1.27); C785(0.95)  LDD1014  [3]
 LDCM0417  CL29 HEK-293T C133(0.85); C62(1.30); C785(0.96)  LDD1015  [3]
 LDCM0419  CL30 HEK-293T C133(0.77); C62(1.84); C785(1.32)  LDD1017  [3]
 LDCM0420  CL31 HEK-293T C785(1.01)  LDD1018  [3]
 LDCM0421  CL32 HEK-293T C785(1.03)  LDD1019  [3]
 LDCM0422  CL33 HEK-293T C785(1.00)  LDD1020  [3]
 LDCM0423  CL34 HEK-293T C785(1.07)  LDD1021  [3]
 LDCM0424  CL35 HEK-293T C785(1.07)  LDD1022  [3]
 LDCM0425  CL36 HEK-293T C785(1.08)  LDD1023  [3]
 LDCM0426  CL37 HEK-293T C785(1.12)  LDD1024  [3]
 LDCM0428  CL39 HEK-293T C785(1.71)  LDD1026  [3]
 LDCM0430  CL40 HEK-293T C785(1.13)  LDD1028  [3]
 LDCM0431  CL41 HEK-293T C785(1.46)  LDD1029  [3]
 LDCM0432  CL42 HEK-293T C785(1.78)  LDD1030  [3]
 LDCM0433  CL43 HEK-293T C785(1.71)  LDD1031  [3]
 LDCM0434  CL44 HEK-293T C785(1.12)  LDD1032  [3]
 LDCM0435  CL45 HEK-293T C785(1.39)  LDD1033  [3]
 LDCM0436  CL46 HEK-293T C785(1.07)  LDD1034  [3]
 LDCM0437  CL47 HEK-293T C785(1.16)  LDD1035  [3]
 LDCM0438  CL48 HEK-293T C785(1.17)  LDD1036  [3]
 LDCM0439  CL49 HEK-293T C785(1.05)  LDD1037  [3]
 LDCM0441  CL50 HEK-293T C785(1.48)  LDD1039  [3]
 LDCM0442  CL51 HEK-293T C785(1.27)  LDD1040  [3]
 LDCM0443  CL52 HEK-293T C785(0.81)  LDD1041  [3]
 LDCM0444  CL53 HEK-293T C785(0.96)  LDD1042  [3]
 LDCM0445  CL54 HEK-293T C785(1.06)  LDD1043  [3]
 LDCM0446  CL55 HEK-293T C785(1.39)  LDD1044  [3]
 LDCM0447  CL56 HEK-293T C785(0.89)  LDD1045  [3]
 LDCM0448  CL57 HEK-293T C785(0.99)  LDD1046  [3]
 LDCM0449  CL58 HEK-293T C785(1.08)  LDD1047  [3]
 LDCM0450  CL59 HEK-293T C785(1.15)  LDD1048  [3]
 LDCM0452  CL60 HEK-293T C785(1.56)  LDD1050  [3]
 LDCM0453  CL61 HEK-293T C133(1.14); C141(1.14)  LDD1051  [3]
 LDCM0454  CL62 HEK-293T C133(1.31); C141(1.31)  LDD1052  [3]
 LDCM0455  CL63 HEK-293T C133(1.60); C141(1.60)  LDD1053  [3]
 LDCM0456  CL64 HEK-293T C133(0.78); C141(0.78)  LDD1054  [3]
 LDCM0457  CL65 HEK-293T C133(1.03); C141(1.03)  LDD1055  [3]
 LDCM0458  CL66 HEK-293T C133(1.23); C141(1.23)  LDD1056  [3]
 LDCM0459  CL67 HEK-293T C133(1.71); C141(1.71)  LDD1057  [3]
 LDCM0460  CL68 HEK-293T C133(1.11); C141(1.11)  LDD1058  [3]
 LDCM0461  CL69 HEK-293T C133(0.94); C141(0.94)  LDD1059  [3]
 LDCM0463  CL70 HEK-293T C133(1.05); C141(1.05)  LDD1061  [3]
 LDCM0464  CL71 HEK-293T C133(0.95); C141(0.95)  LDD1062  [3]
 LDCM0465  CL72 HEK-293T C133(1.25); C141(1.25)  LDD1063  [3]
 LDCM0466  CL73 HEK-293T C133(1.09); C141(1.09)  LDD1064  [3]
 LDCM0467  CL74 HEK-293T C133(0.87); C141(0.87)  LDD1065  [3]
 LDCM0469  CL76 HEK-293T C62(1.26)  LDD1067  [3]
 LDCM0470  CL77 HEK-293T C62(1.67)  LDD1068  [3]
 LDCM0471  CL78 HEK-293T C62(1.99)  LDD1069  [3]
 LDCM0472  CL79 HEK-293T C62(1.60)  LDD1070  [3]
 LDCM0474  CL80 HEK-293T C62(1.24)  LDD1072  [3]
 LDCM0475  CL81 HEK-293T C62(1.32)  LDD1073  [3]
 LDCM0476  CL82 HEK-293T C62(0.90)  LDD1074  [3]
 LDCM0477  CL83 HEK-293T C62(1.11)  LDD1075  [3]
 LDCM0478  CL84 HEK-293T C62(2.00)  LDD1076  [3]
 LDCM0479  CL85 HEK-293T C62(1.51)  LDD1077  [3]
 LDCM0480  CL86 HEK-293T C62(1.75)  LDD1078  [3]
 LDCM0481  CL87 HEK-293T C62(1.71)  LDD1079  [3]
 LDCM0482  CL88 HEK-293T C62(1.34)  LDD1080  [3]
 LDCM0483  CL89 HEK-293T C62(1.59)  LDD1081  [3]
 LDCM0485  CL90 HEK-293T C62(1.51)  LDD1083  [3]
 LDCM0486  CL91 HEK-293T C785(0.97)  LDD1084  [3]
 LDCM0487  CL92 HEK-293T C785(1.02)  LDD1085  [3]
 LDCM0488  CL93 HEK-293T C785(1.09)  LDD1086  [3]
 LDCM0489  CL94 HEK-293T C785(1.34)  LDD1087  [3]
 LDCM0490  CL95 HEK-293T C785(1.66)  LDD1088  [3]
 LDCM0491  CL96 HEK-293T C785(1.33)  LDD1089  [3]
 LDCM0492  CL97 HEK-293T C785(1.06)  LDD1090  [3]
 LDCM0493  CL98 HEK-293T C785(1.19)  LDD1091  [3]
 LDCM0494  CL99 HEK-293T C785(1.33)  LDD1092  [3]
 LDCM0468  Fragment33 HEK-293T C133(0.93); C141(0.93)  LDD1066  [3]
 LDCM0427  Fragment51 HEK-293T C785(1.17)  LDD1025  [3]
 LDCM0022  KB02 BRX211 C753(2.32)  LDD2268  [5]
 LDCM0023  KB03 A375.S2 C753(2.15)  LDD2673  [5]
 LDCM0024  KB05 T cell C62(20.00)  LDD1705  [1]
 LDCM0109  NEM HeLa N.A.  LDD0224  [2]

References

1 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840