Details of the Target

General Information of Target

Target ID LDTP16167
Target Name PHD and RING finger domain-containing protein 1 (PHRF1)
Gene Name PHRF1
Gene ID 57661
Synonyms
KIAA1542; PHD and RING finger domain-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGSLPPCVVDCGTGYTKLGYAGNTEPQFIIPSCIAIRESAKVVDQAQRRVLRGVDDLDF
FIGDEAIDKPTYATKWPIRHGIIEDWDLMERFMEQVVFKYLRAEPEDHYFLMTEPPLNTP
ENREYLAEIMFESFNVPGLYIAVQAVLALAASWTSRQVGERTLTGIVIDSGDGVTHVIPV
AEGYVIGSCIKHIPIAGRDITYFIQQLLREREVGIPPEQSLETAKAIKEKYCYICPDIVK
EFAKYDVDPRKWIKQYTGINAINQKKFVIDVGYERFLGPEIFFHPEFANPDFMESISDVV
DEVIQNCPIDVRRPLYKNVVLSGGSTMFRDFGRRLQRDLKRVVDARLRLSEELSGGRIKP
KPVEVQVVTHHMQRYAVWFGGSMLASTPEFFQVCHTKKDYEEYGPSICRHNPVFGVMS
Target Bioclass
Other
Uniprot ID
Q9P1Y6
Ensemble ID
ENST00000264555.10
HGNC ID
HGNC:24351

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL148 SNV: p.S250F .
CAL33 SNV: p.T595I .
COLO320 SNV: p.A315S DBIA    Probe Info 
HCT15 SNV: p.T353A .
HT115 SNV: p.R149Q .
JHH4 Substitution: p.S292F DBIA    Probe Info 
JURKAT SNV: p.A231D Compound 10    Probe Info 
KP4 SNV: p.A335V .
SNU1196 SNV: p.R681T .
SW1783 SNV: p.A267G DBIA    Probe Info 
SW403 SNV: p.C585F DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K1563(10.00)  LDD0277  [1]
m-APA
 Probe Info  		14.65  LDD0403  [2]
BTD
 Probe Info  		C585(1.04)  LDD2099  [3]
IA-alkyne
 Probe Info  		C585(9.03)  LDD1704  [4]
DBIA
 Probe Info  		C585(0.92)  LDD0078  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [6]
Compound 10
 Probe Info  		C585(0.00); C710(0.00)  LDD2216  [7]
Compound 11
 Probe Info  		C585(0.00); C710(0.00)  LDD2213  [7]
IPM
 Probe Info  		C558(0.00); C407(0.00); C710(0.00); C585(0.00)  LDD0147  [8]
SF
 Probe Info  		N.A.  LDD0028  [9]
TFBX
 Probe Info  		N.A.  LDD0148  [8]
Phosphinate-6
 Probe Info  		C658(0.00); C710(0.00); C797(0.00); C585(0.00)  LDD0018  [10]
AOyne
 Probe Info  		8.60  LDD0443  [11]
HHS-482
 Probe Info  		Y1582(1.88)  LDD2239  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C145(0.99)  LDD0531  [5]
 LDCM0215  AC10 HEK-293T C145(0.90)  LDD0813  [5]
 LDCM0216  AC100 HCT 116 C145(0.80)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C145(0.77)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C145(1.07)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C145(0.80)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C145(0.56)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C145(1.00)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C145(1.14)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C145(0.78)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C145(0.78)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C145(1.32)  LDD0542  [5]
 LDCM0226  AC11 HEK-293T C145(1.04)  LDD0824  [5]
 LDCM0227  AC110 HCT 116 C145(0.91)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C145(1.11)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C145(0.70)  LDD0546  [5]
 LDCM0237  AC12 HEK-293T C145(0.96)  LDD0835  [5]
 LDCM0246  AC128 HEK-293T C145(0.99)  LDD0844  [5]
 LDCM0247  AC129 HEK-293T C145(1.04)  LDD0845  [5]
 LDCM0249  AC130 HEK-293T C145(1.25)  LDD0847  [5]
 LDCM0250  AC131 HEK-293T C145(1.18)  LDD0848  [5]
 LDCM0251  AC132 HEK-293T C145(1.30)  LDD0849  [5]
 LDCM0252  AC133 HEK-293T C145(0.95)  LDD0850  [5]
 LDCM0253  AC134 HEK-293T C145(1.24)  LDD0851  [5]
 LDCM0254  AC135 HEK-293T C145(1.03)  LDD0852  [5]
 LDCM0255  AC136 HEK-293T C145(1.18)  LDD0853  [5]
 LDCM0256  AC137 HEK-293T C145(1.16)  LDD0854  [5]
 LDCM0257  AC138 HEK-293T C145(1.46)  LDD0855  [5]
 LDCM0258  AC139 HEK-293T C145(1.26)  LDD0856  [5]
 LDCM0259  AC14 HEK-293T C145(0.80)  LDD0857  [5]
 LDCM0260  AC140 HEK-293T C145(1.14)  LDD0858  [5]
 LDCM0261  AC141 HEK-293T C145(1.59)  LDD0859  [5]
 LDCM0262  AC142 HEK-293T C145(1.16)  LDD0860  [5]
 LDCM0263  AC143 HEK-293T C145(0.78)  LDD0861  [5]
 LDCM0264  AC144 HEK-293T C145(0.71)  LDD0862  [5]
 LDCM0265  AC145 HEK-293T C145(1.00)  LDD0863  [5]
 LDCM0266  AC146 HEK-293T C145(1.24)  LDD0864  [5]
 LDCM0267  AC147 HEK-293T C145(0.51)  LDD0865  [5]
 LDCM0268  AC148 HEK-293T C145(0.77)  LDD0866  [5]
 LDCM0269  AC149 HEK-293T C145(0.66)  LDD0867  [5]
 LDCM0270  AC15 HEK-293T C145(0.72)  LDD0868  [5]
 LDCM0271  AC150 HEK-293T C145(0.69)  LDD0869  [5]
 LDCM0272  AC151 HEK-293T C145(0.73)  LDD0870  [5]
 LDCM0273  AC152 HEK-293T C145(0.61)  LDD0871  [5]
 LDCM0274  AC153 HEK-293T C145(0.16)  LDD0872  [5]
 LDCM0621  AC154 HEK-293T C145(0.18)  LDD2162  [5]
 LDCM0622  AC155 HEK-293T C145(0.42)  LDD2163  [5]
 LDCM0623  AC156 HEK-293T C145(0.17)  LDD2164  [5]
 LDCM0624  AC157 HEK-293T C145(0.27)  LDD2165  [5]
 LDCM0276  AC17 HEK-293T C145(1.29)  LDD0874  [5]
 LDCM0277  AC18 HEK-293T C145(1.29)  LDD0875  [5]
 LDCM0278  AC19 HEK-293T C145(0.90)  LDD0876  [5]
 LDCM0279  AC2 HCT 116 C145(0.67)  LDD0596  [5]
 LDCM0280  AC20 HEK-293T C145(0.48)  LDD0878  [5]
 LDCM0281  AC21 HEK-293T C145(0.89)  LDD0879  [5]
 LDCM0282  AC22 HEK-293T C145(0.90)  LDD0880  [5]
 LDCM0283  AC23 HEK-293T C145(0.05)  LDD0881  [5]
 LDCM0284  AC24 HEK-293T C145(0.05)  LDD0882  [5]
 LDCM0285  AC25 HEK-293T C145(0.86)  LDD0883  [5]
 LDCM0286  AC26 HEK-293T C145(0.74)  LDD0884  [5]
 LDCM0287  AC27 HEK-293T C145(0.68)  LDD0885  [5]
 LDCM0288  AC28 HEK-293T C145(0.82)  LDD0886  [5]
 LDCM0289  AC29 HEK-293T C145(0.63)  LDD0887  [5]
 LDCM0290  AC3 HCT 116 C145(1.89)  LDD0607  [5]
 LDCM0291  AC30 HEK-293T C145(0.64)  LDD0889  [5]
 LDCM0292  AC31 HEK-293T C145(0.76)  LDD0890  [5]
 LDCM0293  AC32 HEK-293T C145(0.71)  LDD0891  [5]
 LDCM0294  AC33 HEK-293T C145(0.62)  LDD0892  [5]
 LDCM0295  AC34 HEK-293T C145(0.67)  LDD0893  [5]
 LDCM0296  AC35 HCT 116 C145(0.49)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C145(0.35)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C145(0.82)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C145(0.88)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C145(0.60)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C145(1.13)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C145(0.62)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C145(0.77)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C145(1.01)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C145(0.97)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C145(0.59)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C145(0.93)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C145(0.88)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C145(1.49)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C145(0.95)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C145(0.81)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C145(1.54)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C145(0.70)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C145(1.03)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C145(0.77)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C145(0.71)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C145(0.79)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C145(0.74)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C145(0.63)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C145(0.70)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C145(0.72)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C145(0.69)  LDD0639  [5]
 LDCM0323  AC6 HEK-293T C145(0.97)  LDD0921  [5]
 LDCM0324  AC60 HCT 116 C145(0.84)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C145(0.70)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C145(1.05)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C145(0.70)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C145(0.74)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C145(0.94)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C145(0.76)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C145(0.75)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C145(1.24)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C145(1.26)  LDD0650  [5]
 LDCM0334  AC7 HEK-293T C145(0.82)  LDD0932  [5]
 LDCM0335  AC70 HCT 116 C145(0.90)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C145(1.38)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C145(1.07)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C145(1.16)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C145(1.01)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C145(1.14)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C145(1.14)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C145(1.34)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C145(1.01)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C145(1.17)  LDD0661  [5]
 LDCM0345  AC8 HEK-293T C145(0.66)  LDD0943  [5]
 LDCM0346  AC80 HCT 116 C145(0.89)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C145(0.82)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C145(1.22)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C145(0.81)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C145(0.68)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C145(0.77)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C145(1.28)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C145(1.49)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C145(0.86)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C145(0.79)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C145(2.73)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C145(0.80)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C145(1.00)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C145(0.56)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C145(0.92)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C145(1.01)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C145(0.79)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C145(0.92)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C145(0.98)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C145(0.96)  LDD0683  [5]
 LDCM0248  AKOS034007472 HEK-293T C145(0.88)  LDD0846  [5]
 LDCM0356  AKOS034007680 HEK-293T C145(0.78)  LDD0954  [5]
 LDCM0275  AKOS034007705 HEK-293T C145(0.73)  LDD0873  [5]
 LDCM0156  Aniline NCI-H1299 14.65  LDD0403  [2]
 LDCM0020  ARS-1620 HCC44 C585(0.92)  LDD0078  [5]
 LDCM0367  CL1 HEK-293T C145(0.75)  LDD0965  [5]
 LDCM0368  CL10 HEK-293T C145(0.87)  LDD0966  [5]
 LDCM0369  CL100 HCT 116 C145(1.09)  LDD0686  [5]
 LDCM0370  CL101 HEK-293T C145(0.61)  LDD0968  [5]
 LDCM0371  CL102 HEK-293T C145(0.65)  LDD0969  [5]
 LDCM0372  CL103 HEK-293T C145(0.67)  LDD0970  [5]
 LDCM0373  CL104 HEK-293T C145(0.74)  LDD0971  [5]
 LDCM0374  CL105 HEK-293T C145(20.00)  LDD0972  [5]
 LDCM0375  CL106 HEK-293T C145(0.92)  LDD0973  [5]
 LDCM0376  CL107 HEK-293T C145(20.00)  LDD0974  [5]
 LDCM0377  CL108 HEK-293T C145(1.29)  LDD0975  [5]
 LDCM0378  CL109 HEK-293T C145(0.18)  LDD0976  [5]
 LDCM0379  CL11 HEK-293T C145(0.95)  LDD0977  [5]
 LDCM0380  CL110 HEK-293T C145(0.05)  LDD0978  [5]
 LDCM0381  CL111 HEK-293T C145(0.14)  LDD0979  [5]
 LDCM0382  CL112 HEK-293T C145(0.70)  LDD0980  [5]
 LDCM0383  CL113 HEK-293T C145(0.70)  LDD0981  [5]
 LDCM0384  CL114 HEK-293T C145(0.56)  LDD0982  [5]
 LDCM0385  CL115 HEK-293T C145(0.67)  LDD0983  [5]
 LDCM0386  CL116 HEK-293T C145(0.60)  LDD0984  [5]
 LDCM0387  CL117 HCT 116 C145(0.86)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C145(0.64)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C145(0.92)  LDD0706  [5]
 LDCM0390  CL12 HEK-293T C145(0.99)  LDD0988  [5]
 LDCM0391  CL120 HCT 116 C145(0.60)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C145(1.11)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C145(0.68)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C145(0.59)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C145(0.70)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C145(0.74)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C145(0.66)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C145(0.62)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C145(0.73)  LDD0716  [5]
 LDCM0400  CL13 HEK-293T C145(0.88)  LDD0998  [5]
 LDCM0401  CL14 HEK-293T C145(1.03)  LDD0999  [5]
 LDCM0402  CL15 HEK-293T C145(0.86)  LDD1000  [5]
 LDCM0403  CL16 HCT 116 C145(1.33)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C145(1.63)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C145(1.49)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C145(1.59)  LDD0723  [5]
 LDCM0407  CL2 HEK-293T C145(1.06)  LDD1005  [5]
 LDCM0408  CL20 HCT 116 C145(1.43)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C145(1.26)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C145(2.36)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C145(1.20)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C145(1.53)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C145(1.44)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C145(1.44)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C145(1.27)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C145(0.94)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C145(2.14)  LDD0734  [5]
 LDCM0418  CL3 HEK-293T C145(0.91)  LDD1016  [5]
 LDCM0419  CL30 HCT 116 C145(2.00)  LDD0736  [5]
 LDCM0420  CL31 PaTu 8988t C145(1.49)  LDD1299  [5]
 LDCM0421  CL32 PaTu 8988t C145(1.29)  LDD1300  [5]
 LDCM0422  CL33 PaTu 8988t C145(1.12)  LDD1301  [5]
 LDCM0423  CL34 PaTu 8988t C145(1.15)  LDD1302  [5]
 LDCM0424  CL35 PaTu 8988t C145(1.28)  LDD1303  [5]
 LDCM0425  CL36 PaTu 8988t C145(0.62)  LDD1304  [5]
 LDCM0426  CL37 PaTu 8988t C145(1.56)  LDD1305  [5]
 LDCM0428  CL39 PaTu 8988t C145(1.40)  LDD1307  [5]
 LDCM0429  CL4 HEK-293T C145(0.82)  LDD1027  [5]
 LDCM0430  CL40 PaTu 8988t C145(1.59)  LDD1309  [5]
 LDCM0431  CL41 PaTu 8988t C145(1.29)  LDD1310  [5]
 LDCM0432  CL42 PaTu 8988t C145(1.39)  LDD1311  [5]
 LDCM0433  CL43 PaTu 8988t C145(1.36)  LDD1312  [5]
 LDCM0434  CL44 PaTu 8988t C145(1.38)  LDD1313  [5]
 LDCM0435  CL45 PaTu 8988t C145(1.12)  LDD1314  [5]
 LDCM0436  CL46 HEK-293T C145(0.66)  LDD1034  [5]
 LDCM0437  CL47 HEK-293T C145(0.78)  LDD1035  [5]
 LDCM0438  CL48 HEK-293T C145(0.72)  LDD1036  [5]
 LDCM0439  CL49 HEK-293T C145(0.75)  LDD1037  [5]
 LDCM0440  CL5 HEK-293T C145(0.99)  LDD1038  [5]
 LDCM0441  CL50 HEK-293T C145(0.68)  LDD1039  [5]
 LDCM0442  CL51 HEK-293T C145(0.85)  LDD1040  [5]
 LDCM0443  CL52 HEK-293T C145(1.12)  LDD1041  [5]
 LDCM0444  CL53 HEK-293T C145(1.01)  LDD1042  [5]
 LDCM0445  CL54 HEK-293T C145(0.82)  LDD1043  [5]
 LDCM0446  CL55 HEK-293T C145(0.68)  LDD1044  [5]
 LDCM0447  CL56 HEK-293T C145(0.74)  LDD1045  [5]
 LDCM0448  CL57 HEK-293T C145(0.86)  LDD1046  [5]
 LDCM0449  CL58 HEK-293T C145(1.02)  LDD1047  [5]
 LDCM0450  CL59 HEK-293T C145(0.68)  LDD1048  [5]
 LDCM0451  CL6 HEK-293T C145(0.90)  LDD1049  [5]
 LDCM0452  CL60 HEK-293T C145(0.63)  LDD1050  [5]
 LDCM0453  CL61 HEK-293T C145(0.90)  LDD1051  [5]
 LDCM0454  CL62 HEK-293T C145(0.66)  LDD1052  [5]
 LDCM0455  CL63 HEK-293T C145(0.66)  LDD1053  [5]
 LDCM0456  CL64 HEK-293T C145(0.90)  LDD1054  [5]
 LDCM0457  CL65 HEK-293T C145(0.78)  LDD1055  [5]
 LDCM0458  CL66 HEK-293T C145(0.81)  LDD1056  [5]
 LDCM0459  CL67 HEK-293T C145(0.82)  LDD1057  [5]
 LDCM0460  CL68 HEK-293T C145(0.82)  LDD1058  [5]
 LDCM0461  CL69 HEK-293T C145(0.88)  LDD1059  [5]
 LDCM0462  CL7 HEK-293T C145(1.00)  LDD1060  [5]
 LDCM0463  CL70 HEK-293T C145(0.76)  LDD1061  [5]
 LDCM0464  CL71 HEK-293T C145(0.69)  LDD1062  [5]
 LDCM0465  CL72 HEK-293T C145(0.69)  LDD1063  [5]
 LDCM0466  CL73 HEK-293T C145(0.73)  LDD1064  [5]
 LDCM0467  CL74 HEK-293T C145(0.52)  LDD1065  [5]
 LDCM0469  CL76 HEK-293T C145(1.03)  LDD1067  [5]
 LDCM0470  CL77 HEK-293T C145(0.99)  LDD1068  [5]
 LDCM0471  CL78 HEK-293T C145(0.94)  LDD1069  [5]
 LDCM0472  CL79 HEK-293T C145(1.03)  LDD1070  [5]
 LDCM0473  CL8 HEK-293T C145(0.76)  LDD1071  [5]
 LDCM0474  CL80 HEK-293T C145(1.15)  LDD1072  [5]
 LDCM0475  CL81 HEK-293T C145(1.23)  LDD1073  [5]
 LDCM0476  CL82 HEK-293T C145(1.30)  LDD1074  [5]
 LDCM0477  CL83 HEK-293T C145(1.46)  LDD1075  [5]
 LDCM0478  CL84 HEK-293T C145(1.04)  LDD1076  [5]
 LDCM0479  CL85 HEK-293T C145(1.06)  LDD1077  [5]
 LDCM0480  CL86 HEK-293T C145(0.83)  LDD1078  [5]
 LDCM0481  CL87 HEK-293T C145(0.90)  LDD1079  [5]
 LDCM0482  CL88 HEK-293T C145(1.05)  LDD1080  [5]
 LDCM0483  CL89 HEK-293T C145(1.14)  LDD1081  [5]
 LDCM0484  CL9 HEK-293T C145(0.87)  LDD1082  [5]
 LDCM0485  CL90 HEK-293T C145(1.00)  LDD1083  [5]
 LDCM0486  CL91 HCT 116 C145(1.10)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C145(1.25)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C145(0.62)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C145(1.21)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C145(0.86)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C145(0.85)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C145(0.72)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C145(1.57)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C145(0.91)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C658(1.13); C962(1.02)  LDD1698  [13]
 LDCM0468  Fragment33 HEK-293T C145(0.64)  LDD1066  [5]
 LDCM0427  Fragment51 PaTu 8988t C145(1.49)  LDD1306  [5]
 LDCM0022  KB02 HEK-293T C658(0.92); C1123(0.84); C710(0.96); C949(1.02)  LDD1492  [13]
 LDCM0023  KB03 Jurkat C558(5.30)  LDD0209  [14]
 LDCM0024  KB05 COLO792 C145(1.52)  LDD3310  [15]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C585(1.04)  LDD2099  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C585(0.78)  LDD2109  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C585(0.85)  LDD2129  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C585(1.26)  LDD2136  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C585(0.80)  LDD2140  [3]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C585(2.31)  LDD2144  [3]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
10 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
15 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840