Details of the Target

General Information of Target

Target ID LDTP15932
Target Name Probable ribonuclease ZC3H12C (ZC3H12C)
Gene Name ZC3H12C
Gene ID 85463
Synonyms
KIAA1726; MCPIP3; Probable ribonuclease ZC3H12C; EC 3.1.-.-; MCP-induced protein 3; Zinc finger CCCH domain-containing protein 12C
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPEDQAGAAMEEASPYSLLDICLNFLTTHLEKFCSARQDGTLCLQEPGVFPQEVADRLLR
TMAFHGLLNDGTVGIFRGNQMRLKRACIRKAKISAVAFRKAFCHHKLVELDATGVNADIT
ITDIISGLGSNKWIQQNLQCLVLNSLTLSLEDPYERCFSRLSGLRALSITNVLFYNEDLA
EVASLPRLESLDISNTSITDITALLACKDRLKSLTMHHLKCLKMTTTQILDVVRELKHLN
HLDISDDKQFTSDIALRLLEQKDILPNLVSLDVSGRKHVTDKAVEAFIQQRPSMQFVGLL
ATDAGYSEFLTGEGHLKVSGEANETQIAEALKRYSERAFFVREALFHLFSLTHVMEKTKP
EILKLVVTGMRNHPMNLPVQLAASACVFNLTKQDLAAGMPVRLLADVTHLLLKAMEHFPN
HQQLQKNCLLSLCSDRILQDVPFNRFEAAKLVMQWLCNHEDQNMQRMAVAIISILAAKLS
TEQTAQLGTELFIVRQLLQIVKQKTNQNSVDTTLKFTLSALWNLTDESPTTCRHFIENQG
LELFMRVLESFPTESSIQQKVLGLLNNIAEVQELHSELMWKDFIDHISSLLHSVEVEVSY
FAAGIIAHLISRGEQAWTLSRSQRNSLLDDLHSAILKWPTPECEMVAYRSFNPFFPLLGC
FTTPGVQLWAVWAMQHVCSKNPSRYCSMLIEEGGLQHLYNIKDHEHTDPHVQQIAVAILD
SLEKHIVRHGRPPPCKKQPQARLN
Target Bioclass
Enzyme
Family
ZC3H12 family
Function May function as RNase and regulate the levels of target RNA species.
Uniprot ID
Q9C0D7
Ensemble ID
ENST00000278590.8
HGNC ID
HGNC:29362

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL148 SNV: p.E365K .
ETK1 SNV: p.S752C .
HCT15 SNV: p.G642C .
HEC1 Substitution: p.T497M .
HEC1B Substitution: p.T497M .
HLF SNV: p.R686S .
HT SNV: p.V331A; p.D335A .
LS123 Insertion: p.D445GfsTer23 .
MFE319 SNV: p.Q556Ter .
RCC10RGB SNV: p.G882R .
SSP25 SNV: p.S752C .
SUPT1 Deletion: p.N20TfsTer15 .
SW403 SNV: p.V351M .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C333(1.01)  LDD0532  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HCT 116 C333(1.01)  LDD0532  [1]
 LDCM0226  AC11 HCT 116 C333(0.85)  LDD0543  [1]
 LDCM0230  AC113 HCT 116 C333(0.95)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C333(0.88)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C333(1.06)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C333(0.93)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C333(1.05)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C333(0.98)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C333(1.11)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C333(1.04)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C333(0.79)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C333(0.84)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C333(1.03)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C333(0.71)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C333(0.81)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C333(0.87)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C333(0.75)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C333(0.90)  LDD0562  [1]
 LDCM0246  AC128 HEK-293T C333(0.93)  LDD0844  [1]
 LDCM0247  AC129 HEK-293T C333(1.23)  LDD0845  [1]
 LDCM0249  AC130 HEK-293T C333(0.96)  LDD0847  [1]
 LDCM0250  AC131 HEK-293T C333(0.99)  LDD0848  [1]
 LDCM0251  AC132 HEK-293T C333(1.39)  LDD0849  [1]
 LDCM0252  AC133 HEK-293T C333(1.04)  LDD0850  [1]
 LDCM0253  AC134 HEK-293T C333(0.93)  LDD0851  [1]
 LDCM0254  AC135 HEK-293T C333(1.10)  LDD0852  [1]
 LDCM0255  AC136 HEK-293T C333(1.11)  LDD0853  [1]
 LDCM0256  AC137 HEK-293T C333(1.09)  LDD0854  [1]
 LDCM0257  AC138 HEK-293T C333(1.17)  LDD0855  [1]
 LDCM0258  AC139 HEK-293T C333(1.05)  LDD0856  [1]
 LDCM0259  AC14 HCT 116 C333(0.82)  LDD0576  [1]
 LDCM0260  AC140 HEK-293T C333(1.09)  LDD0858  [1]
 LDCM0261  AC141 HEK-293T C333(1.40)  LDD0859  [1]
 LDCM0262  AC142 HEK-293T C333(1.18)  LDD0860  [1]
 LDCM0263  AC143 HCT 116 C333(1.09)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C333(0.96)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C333(0.96)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C333(1.22)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C333(1.08)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C333(1.12)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C333(1.05)  LDD0586  [1]
 LDCM0270  AC15 HCT 116 C333(0.91)  LDD0587  [1]
 LDCM0271  AC150 HCT 116 C333(0.98)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C333(0.95)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C333(0.95)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C333(1.21)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C333(1.00)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C333(1.11)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C333(1.07)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C333(1.22)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C333(1.01)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C333(0.87)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C333(0.90)  LDD0595  [1]
 LDCM0280  AC20 HCT 116 C333(1.05)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C333(0.80)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C333(0.92)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C333(0.85)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C333(1.04)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C333(0.75)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C333(1.23)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C333(1.23)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C333(1.25)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C333(1.40)  LDD0606  [1]
 LDCM0291  AC30 HCT 116 C333(1.44)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C333(1.30)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C333(1.46)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C333(1.20)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C333(1.03)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C333(0.74)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C333(0.76)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C333(0.77)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C333(0.80)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C333(0.70)  LDD0617  [1]
 LDCM0302  AC40 HCT 116 C333(0.64)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C333(0.86)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C333(0.96)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C333(0.68)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C333(0.64)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C333(0.58)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C333(1.04)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C333(0.95)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C333(0.76)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C333(0.88)  LDD0628  [1]
 LDCM0313  AC50 HCT 116 C333(0.80)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C333(0.83)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C333(0.77)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C333(0.79)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C333(0.64)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C333(1.12)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C333(1.15)  LDD0636  [1]
 LDCM0320  AC57 HEK-293T C333(0.89)  LDD0918  [1]
 LDCM0321  AC58 HEK-293T C333(1.05)  LDD0919  [1]
 LDCM0322  AC59 HEK-293T C333(1.14)  LDD0920  [1]
 LDCM0323  AC6 HCT 116 C333(1.04)  LDD0640  [1]
 LDCM0324  AC60 HEK-293T C333(1.24)  LDD0922  [1]
 LDCM0325  AC61 HEK-293T C333(1.17)  LDD0923  [1]
 LDCM0326  AC62 HEK-293T C333(1.11)  LDD0924  [1]
 LDCM0327  AC63 HEK-293T C333(1.08)  LDD0925  [1]
 LDCM0328  AC64 HEK-293T C333(1.19)  LDD0926  [1]
 LDCM0329  AC65 HEK-293T C333(1.27)  LDD0927  [1]
 LDCM0330  AC66 HEK-293T C333(1.01)  LDD0928  [1]
 LDCM0331  AC67 HEK-293T C333(1.04)  LDD0929  [1]
 LDCM0332  AC68 HCT 116 C333(0.80)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C333(0.87)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C333(1.05)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C333(1.06)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C333(0.75)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C333(1.05)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C333(0.99)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C333(0.81)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C333(1.03)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C333(0.80)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C333(0.87)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C333(0.85)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C333(1.04)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C333(0.93)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C333(0.72)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C333(0.84)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C333(0.75)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C333(1.28)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C333(1.07)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C333(1.19)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C333(1.25)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C333(1.34)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C333(0.99)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C333(1.08)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C333(1.09)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C333(1.06)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C333(1.15)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C333(1.03)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C333(1.15)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C333(1.14)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C333(1.18)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C333(1.34)  LDD0681  [1]
 LDCM0248  AKOS034007472 HCT 116 C333(1.02)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C333(0.84)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C333(1.00)  LDD0592  [1]
 LDCM0367  CL1 HCT 116 C333(1.34)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C333(1.31)  LDD0685  [1]
 LDCM0370  CL101 HCT 116 C333(1.08)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C333(1.02)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C333(0.93)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C333(0.79)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C333(0.84)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C333(0.83)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C333(0.81)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C333(0.92)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C333(1.00)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C333(1.33)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C333(0.98)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C333(1.24)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C333(0.90)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C333(1.20)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C333(1.57)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C333(1.21)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C333(1.07)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C333(0.56)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C333(0.89)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C333(0.95)  LDD0706  [1]
 LDCM0390  CL12 HCT 116 C333(1.37)  LDD0707  [1]
 LDCM0391  CL120 HCT 116 C333(0.73)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C333(0.99)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C333(0.94)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C333(0.78)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C333(0.86)  LDD0712  [1]
 LDCM0396  CL125 HEK-293T C333(0.99)  LDD0994  [1]
 LDCM0397  CL126 HEK-293T C333(0.99)  LDD0995  [1]
 LDCM0398  CL127 HEK-293T C333(1.09)  LDD0996  [1]
 LDCM0399  CL128 HEK-293T C333(1.17)  LDD0997  [1]
 LDCM0400  CL13 HCT 116 C333(1.11)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C333(1.14)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C333(1.13)  LDD0719  [1]
 LDCM0404  CL17 HCT 116 C333(0.87)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C333(0.91)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C333(0.83)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C333(1.07)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C333(1.01)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C333(1.23)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C333(0.80)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C333(1.00)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C333(0.81)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C333(0.98)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C333(0.86)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C333(0.94)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C333(0.74)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C333(0.91)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C333(1.23)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C333(0.94)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C333(0.88)  LDD0737  [1]
 LDCM0429  CL4 HCT 116 C333(1.06)  LDD0746  [1]
 LDCM0440  CL5 HCT 116 C333(1.02)  LDD0757  [1]
 LDCM0451  CL6 HCT 116 C333(1.16)  LDD0768  [1]
 LDCM0453  CL61 HCT 116 C333(1.51)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C333(1.23)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C333(1.01)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C333(1.22)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C333(1.08)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C333(1.49)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C333(1.08)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C333(1.07)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C333(1.37)  LDD0778  [1]
 LDCM0462  CL7 HCT 116 C333(1.12)  LDD0779  [1]
 LDCM0463  CL70 HCT 116 C333(1.08)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C333(1.14)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C333(1.26)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C333(1.20)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C333(1.11)  LDD0784  [1]
 LDCM0469  CL76 HCT 116 C333(0.80)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C333(0.80)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C333(0.85)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C333(1.02)  LDD0789  [1]
 LDCM0473  CL8 HCT 116 C333(1.36)  LDD0790  [1]
 LDCM0474  CL80 HCT 116 C333(0.83)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C333(0.98)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C333(0.85)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C333(0.98)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C333(1.04)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C333(0.91)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C333(0.86)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C333(0.87)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C333(0.80)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C333(0.77)  LDD0800  [1]
 LDCM0484  CL9 HCT 116 C333(1.06)  LDD0801  [1]
 LDCM0485  CL90 HCT 116 C333(1.13)  LDD0802  [1]
 LDCM0468  Fragment33 HCT 116 C333(1.25)  LDD0785  [1]
 LDCM0022  KB02 A2058 C126(1.85)  LDD2253  [2]
 LDCM0023  KB03 A2058 C126(1.88)  LDD2670  [2]
 LDCM0024  KB05 OCUG-1 C126(3.12)  LDD3373  [2]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840