Details of the Target

General Information of Target

Target ID LDTP15916
Target Name Large ribosomal subunit protein bL9m (MRPL9)
Gene Name MRPL9
Gene ID 65005
Synonyms
Large ribosomal subunit protein bL9m; 39S ribosomal protein L9, mitochondrial; L9mt; MRP-L9
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSFSRAPQQWATFARIWYLLDGKMQPPGKLAAMASIRLQGLHKPVYHALSDCGDHVVIM
NTRHIAFSGNKWEQKVYSSHTGYPGGFRQVTAAQLHLRDPVAIVKLAIYGMLPKNLHRRT
MMERLHLFPDEYIPEDILKNLVEELPQPRKIPKRLDEYTQEEIDAFPRLWTPPEDYRL
Target Bioclass
Other
Family
Bacterial ribosomal protein bL9 family
Subcellular location
Mitochondrion
Uniprot ID
Q9BYD2
Ensemble ID
ENST00000368830.8
HGNC ID
HGNC:14277

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C221(1.34)  LDD0563  [1]
5E-2FA
 Probe Info  		N.A.  LDD2235  [2]
m-APA
 Probe Info  		H204(0.00); H88(0.00)  LDD2231  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [3]
1c-yne
 Probe Info  		N.A.  LDD0228  [4]
Acrolein
 Probe Info  		N.A.  LDD0217  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C221(0.34)  LDD1093  [1]
 LDCM0216  AC100 PaTu 8988t C221(0.40)  LDD1095  [1]
 LDCM0217  AC101 PaTu 8988t C221(0.69)  LDD1096  [1]
 LDCM0218  AC102 PaTu 8988t C221(1.37)  LDD1097  [1]
 LDCM0219  AC103 PaTu 8988t C221(0.98)  LDD1098  [1]
 LDCM0220  AC104 PaTu 8988t C221(0.52)  LDD1099  [1]
 LDCM0221  AC105 PaTu 8988t C221(0.85)  LDD1100  [1]
 LDCM0222  AC106 PaTu 8988t C221(0.42)  LDD1101  [1]
 LDCM0223  AC107 PaTu 8988t C221(1.34)  LDD1102  [1]
 LDCM0224  AC108 PaTu 8988t C221(0.39)  LDD1103  [1]
 LDCM0225  AC109 PaTu 8988t C221(0.60)  LDD1104  [1]
 LDCM0227  AC110 PaTu 8988t C221(0.72)  LDD1106  [1]
 LDCM0228  AC111 PaTu 8988t C221(0.27)  LDD1107  [1]
 LDCM0229  AC112 PaTu 8988t C221(0.58)  LDD1108  [1]
 LDCM0230  AC113 PaTu 8988t C221(1.33)  LDD1109  [1]
 LDCM0231  AC114 PaTu 8988t C221(1.37)  LDD1110  [1]
 LDCM0232  AC115 PaTu 8988t C221(1.10)  LDD1111  [1]
 LDCM0233  AC116 PaTu 8988t C221(0.95)  LDD1112  [1]
 LDCM0234  AC117 PaTu 8988t C221(1.12)  LDD1113  [1]
 LDCM0235  AC118 PaTu 8988t C221(1.88)  LDD1114  [1]
 LDCM0236  AC119 PaTu 8988t C221(0.44)  LDD1115  [1]
 LDCM0238  AC120 PaTu 8988t C221(1.21)  LDD1117  [1]
 LDCM0239  AC121 PaTu 8988t C221(0.49)  LDD1118  [1]
 LDCM0240  AC122 PaTu 8988t C221(1.18)  LDD1119  [1]
 LDCM0241  AC123 PaTu 8988t C221(0.50)  LDD1120  [1]
 LDCM0242  AC124 PaTu 8988t C221(0.58)  LDD1121  [1]
 LDCM0243  AC125 PaTu 8988t C221(1.03)  LDD1122  [1]
 LDCM0244  AC126 PaTu 8988t C221(1.41)  LDD1123  [1]
 LDCM0245  AC127 PaTu 8988t C221(0.63)  LDD1124  [1]
 LDCM0246  AC128 HCT 116 C221(1.34)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C221(2.16)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C221(0.99)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C221(2.05)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C221(2.56)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C221(1.19)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C221(1.25)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C221(1.27)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C221(1.39)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C221(1.51)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C221(1.20)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C221(1.62)  LDD0575  [1]
 LDCM0260  AC140 HCT 116 C221(1.25)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C221(1.58)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C221(2.35)  LDD0579  [1]
 LDCM0263  AC143 PaTu 8988t C221(0.85)  LDD1142  [1]
 LDCM0264  AC144 PaTu 8988t C221(1.15)  LDD1143  [1]
 LDCM0265  AC145 PaTu 8988t C221(1.21)  LDD1144  [1]
 LDCM0266  AC146 PaTu 8988t C221(1.02)  LDD1145  [1]
 LDCM0267  AC147 PaTu 8988t C221(0.89)  LDD1146  [1]
 LDCM0268  AC148 PaTu 8988t C221(0.87)  LDD1147  [1]
 LDCM0269  AC149 PaTu 8988t C221(0.73)  LDD1148  [1]
 LDCM0271  AC150 PaTu 8988t C221(0.97)  LDD1150  [1]
 LDCM0272  AC151 PaTu 8988t C221(0.90)  LDD1151  [1]
 LDCM0273  AC152 PaTu 8988t C221(0.80)  LDD1152  [1]
 LDCM0274  AC153 PaTu 8988t C221(0.71)  LDD1153  [1]
 LDCM0621  AC154 PaTu 8988t C221(0.82)  LDD2166  [1]
 LDCM0622  AC155 PaTu 8988t C221(1.01)  LDD2167  [1]
 LDCM0623  AC156 PaTu 8988t C221(0.80)  LDD2168  [1]
 LDCM0624  AC157 PaTu 8988t C221(1.12)  LDD2169  [1]
 LDCM0276  AC17 PaTu 8988t C221(0.71)  LDD1155  [1]
 LDCM0277  AC18 PaTu 8988t C221(0.36)  LDD1156  [1]
 LDCM0278  AC19 PaTu 8988t C221(0.64)  LDD1157  [1]
 LDCM0279  AC2 PaTu 8988t C221(0.33)  LDD1158  [1]
 LDCM0280  AC20 PaTu 8988t C221(0.56)  LDD1159  [1]
 LDCM0281  AC21 PaTu 8988t C221(0.62)  LDD1160  [1]
 LDCM0282  AC22 PaTu 8988t C221(0.50)  LDD1161  [1]
 LDCM0283  AC23 PaTu 8988t C221(0.31)  LDD1162  [1]
 LDCM0284  AC24 PaTu 8988t C221(0.59)  LDD1163  [1]
 LDCM0290  AC3 PaTu 8988t C221(0.59)  LDD1169  [1]
 LDCM0301  AC4 PaTu 8988t C221(0.56)  LDD1180  [1]
 LDCM0308  AC46 PaTu 8988t C221(0.95)  LDD1187  [1]
 LDCM0309  AC47 PaTu 8988t C221(1.11)  LDD1188  [1]
 LDCM0310  AC48 PaTu 8988t C221(0.76)  LDD1189  [1]
 LDCM0311  AC49 PaTu 8988t C221(0.63)  LDD1190  [1]
 LDCM0312  AC5 PaTu 8988t C221(0.32)  LDD1191  [1]
 LDCM0313  AC50 PaTu 8988t C221(0.66)  LDD1192  [1]
 LDCM0314  AC51 PaTu 8988t C221(1.00)  LDD1193  [1]
 LDCM0315  AC52 PaTu 8988t C221(0.72)  LDD1194  [1]
 LDCM0316  AC53 PaTu 8988t C221(0.73)  LDD1195  [1]
 LDCM0317  AC54 PaTu 8988t C221(0.73)  LDD1196  [1]
 LDCM0318  AC55 PaTu 8988t C221(1.10)  LDD1197  [1]
 LDCM0319  AC56 PaTu 8988t C221(0.92)  LDD1198  [1]
 LDCM0332  AC68 HCT 116 C221(0.73)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C221(0.81)  LDD0650  [1]
 LDCM0335  AC70 HCT 116 C221(0.85)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C221(0.88)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C221(0.70)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C221(1.02)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C221(1.00)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C221(1.08)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C221(1.03)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C221(0.97)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C221(1.61)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C221(0.76)  LDD0661  [1]
 LDCM0346  AC80 HCT 116 C221(0.87)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C221(1.10)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C221(1.01)  LDD0665  [1]
 LDCM0365  AC98 PaTu 8988t C221(1.02)  LDD1244  [1]
 LDCM0366  AC99 PaTu 8988t C221(0.45)  LDD1245  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [5]
 LDCM0369  CL100 PaTu 8988t C221(0.53)  LDD1248  [1]
 LDCM0374  CL105 PaTu 8988t C221(0.80)  LDD1253  [1]
 LDCM0375  CL106 PaTu 8988t C221(0.65)  LDD1254  [1]
 LDCM0376  CL107 PaTu 8988t C221(0.81)  LDD1255  [1]
 LDCM0377  CL108 PaTu 8988t C221(0.75)  LDD1256  [1]
 LDCM0378  CL109 PaTu 8988t C221(0.50)  LDD1257  [1]
 LDCM0380  CL110 PaTu 8988t C221(0.38)  LDD1259  [1]
 LDCM0381  CL111 PaTu 8988t C221(0.32)  LDD1260  [1]
 LDCM0392  CL121 PaTu 8988t C221(1.17)  LDD1271  [1]
 LDCM0393  CL122 PaTu 8988t C221(0.69)  LDD1272  [1]
 LDCM0394  CL123 PaTu 8988t C221(0.77)  LDD1273  [1]
 LDCM0395  CL124 PaTu 8988t C221(0.74)  LDD1274  [1]
 LDCM0403  CL16 HCT 116 C221(0.62)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C221(0.86)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C221(1.74)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C221(0.78)  LDD0723  [1]
 LDCM0408  CL20 HCT 116 C221(0.44)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C221(0.42)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C221(0.60)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C221(0.39)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C221(0.47)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C221(0.40)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C221(0.40)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C221(0.48)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C221(0.48)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C221(0.50)  LDD0734  [1]
 LDCM0419  CL30 HCT 116 C221(0.75)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C221(0.57)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C221(1.05)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C221(1.17)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C221(0.47)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C221(0.41)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C221(0.64)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C221(0.54)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C221(0.46)  LDD0745  [1]
 LDCM0430  CL40 HCT 116 C221(0.45)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C221(0.51)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C221(0.39)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C221(0.48)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C221(0.43)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C221(0.64)  LDD0752  [1]
 LDCM0436  CL46 HCT 116 C221(2.43)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C221(2.03)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C221(2.05)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C221(0.68)  LDD0756  [1]
 LDCM0441  CL50 HCT 116 C221(1.73)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C221(1.85)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C221(2.47)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C221(1.77)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C221(1.38)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C221(1.72)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C221(0.83)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C221(2.00)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C221(1.87)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C221(0.88)  LDD0767  [1]
 LDCM0452  CL60 HCT 116 C221(1.13)  LDD0769  [1]
 LDCM0453  CL61 PaTu 8988t C221(1.55)  LDD1332  [1]
 LDCM0454  CL62 PaTu 8988t C221(1.53)  LDD1333  [1]
 LDCM0455  CL63 PaTu 8988t C221(1.40)  LDD1334  [1]
 LDCM0456  CL64 PaTu 8988t C221(1.10)  LDD1335  [1]
 LDCM0457  CL65 PaTu 8988t C221(0.90)  LDD1336  [1]
 LDCM0458  CL66 PaTu 8988t C221(0.69)  LDD1337  [1]
 LDCM0459  CL67 PaTu 8988t C221(0.72)  LDD1338  [1]
 LDCM0460  CL68 PaTu 8988t C221(0.96)  LDD1339  [1]
 LDCM0461  CL69 PaTu 8988t C221(0.61)  LDD1340  [1]
 LDCM0463  CL70 PaTu 8988t C221(0.81)  LDD1342  [1]
 LDCM0464  CL71 PaTu 8988t C221(1.40)  LDD1343  [1]
 LDCM0465  CL72 PaTu 8988t C221(1.85)  LDD1344  [1]
 LDCM0466  CL73 PaTu 8988t C221(0.92)  LDD1345  [1]
 LDCM0467  CL74 PaTu 8988t C221(2.06)  LDD1346  [1]
 LDCM0469  CL76 PaTu 8988t C221(1.10)  LDD1348  [1]
 LDCM0470  CL77 PaTu 8988t C221(0.94)  LDD1349  [1]
 LDCM0471  CL78 PaTu 8988t C221(0.78)  LDD1350  [1]
 LDCM0472  CL79 PaTu 8988t C221(0.86)  LDD1351  [1]
 LDCM0474  CL80 PaTu 8988t C221(1.17)  LDD1353  [1]
 LDCM0475  CL81 PaTu 8988t C221(0.39)  LDD1354  [1]
 LDCM0476  CL82 PaTu 8988t C221(0.82)  LDD1355  [1]
 LDCM0477  CL83 PaTu 8988t C221(0.71)  LDD1356  [1]
 LDCM0478  CL84 PaTu 8988t C221(0.40)  LDD1357  [1]
 LDCM0479  CL85 PaTu 8988t C221(0.74)  LDD1358  [1]
 LDCM0480  CL86 PaTu 8988t C221(1.04)  LDD1359  [1]
 LDCM0481  CL87 PaTu 8988t C221(0.41)  LDD1360  [1]
 LDCM0482  CL88 PaTu 8988t C221(0.49)  LDD1361  [1]
 LDCM0483  CL89 PaTu 8988t C221(0.42)  LDD1362  [1]
 LDCM0485  CL90 PaTu 8988t C221(0.35)  LDD1364  [1]
 LDCM0486  CL91 PaTu 8988t C221(0.62)  LDD1365  [1]
 LDCM0487  CL92 PaTu 8988t C221(0.37)  LDD1366  [1]
 LDCM0488  CL93 PaTu 8988t C221(0.41)  LDD1367  [1]
 LDCM0489  CL94 PaTu 8988t C221(0.30)  LDD1368  [1]
 LDCM0490  CL95 PaTu 8988t C221(0.34)  LDD1369  [1]
 LDCM0491  CL96 PaTu 8988t C221(0.59)  LDD1370  [1]
 LDCM0492  CL97 PaTu 8988t C221(0.35)  LDD1371  [1]
 LDCM0493  CL98 PaTu 8988t C221(0.37)  LDD1372  [1]
 LDCM0494  CL99 PaTu 8988t C221(0.34)  LDD1373  [1]
 LDCM0468  Fragment33 PaTu 8988t C221(0.74)  LDD1347  [1]
 LDCM0427  Fragment51 HCT 116 C221(0.42)  LDD0744  [1]
 LDCM0107  IAA HeLa N.A.  LDD0221  [5]
 LDCM0022  KB02 DU145 C221(1.60)  LDD2318  [6]
 LDCM0023  KB03 DU145 C221(1.27)  LDD2735  [6]
 LDCM0024  KB05 REC-1 C221(1.50)  LDD3402  [6]
 LDCM0109  NEM HeLa N.A.  LDD0223  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hsp90 co-chaperone Cdc37 (CDC37) CDC37 family Q16543
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM9B (FAM9B) FAM9 family Q8IZU0

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840