Details of the Target

General Information of Target

Target ID LDTP15060
Target Name Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform (PPP2R2D)
Gene Name PPP2R2D
Gene ID 55844
Synonyms
KIAA1541; Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform; PP2A subunit B isoform B55-delta; PP2A subunit B isoform PR55-delta; PP2A subunit B isoform R2-delta; PP2A subunit B isoform delta
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPGTVATLRFQLLPPEPDDAFWGAPCEQPLERRYQALPALVCIMCCLFGVVYCFFGYRCF
KAVLFLTGLLFGSVVIFLLCYRERVLETQLSAGASAGIALGIGLLCGLVAMLVRSVGLFL
VGLLLGLLLAAAALLGSAPYYQPGSVWGPLGLLLGGGLLCALLTLRWPRPLTTLATAVTG
AALIATAADYFAELLLLGRYVVERLRAAPVPPLCWRSWALLALWPLLSLMGVLVQWRVTA
EGDSHTEVVISRQRRRVQLMRIRQQEDRKEKRRKKRPPRAPLRGPRAPPRPGPPDPAYRR
RPVPIKRFNGDVLSPSYIQSFRDRQTGSSLSSFMASPTDADYEYGSRGPLTACSGPPVRV
Target Bioclass
Enzyme
Family
Phosphatase 2A regulatory subunit B family
Subcellular location
Cytoplasm
Function
B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and may also direct the localization of the catalytic enzyme to a particular subcellular compartment.
Uniprot ID
Q66LE6
Ensemble ID
ENST00000455566.6
HGNC ID
HGNC:23732

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C340(4.26)  LDD0209  [1]
HHS-475
 Probe Info  		Y92(3.70)  LDD0264  [2]
IPM
 Probe Info  		C404(1.54)  LDD1701  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		C268(0.00); C404(0.00); C245(0.00)  LDD0038  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		C245(0.00); C268(0.00)  LDD0037  [4]
BTD
 Probe Info  		N.A.  LDD0004  [5]
AOyne
 Probe Info  		15.00  LDD0443  [6]
NAIA_5
 Probe Info  		N.A.  LDD2223  [7]
HHS-465
 Probe Info  		N.A.  LDD2240  [8]
HHS-482
 Probe Info  		Y92(1.35)  LDD2239  [9]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C268(0.84)  LDD0812  [11]
 LDCM0215  AC10 HEK-293T C268(0.94)  LDD0813  [11]
 LDCM0216  AC100 HEK-293T C268(0.94)  LDD0814  [11]
 LDCM0217  AC101 HEK-293T C268(0.93)  LDD0815  [11]
 LDCM0218  AC102 HEK-293T C268(0.90)  LDD0816  [11]
 LDCM0219  AC103 HEK-293T C268(0.93)  LDD0817  [11]
 LDCM0220  AC104 HEK-293T C268(0.91)  LDD0818  [11]
 LDCM0221  AC105 HEK-293T C268(1.06)  LDD0819  [11]
 LDCM0222  AC106 HEK-293T C268(0.86)  LDD0820  [11]
 LDCM0223  AC107 HEK-293T C268(0.87)  LDD0821  [11]
 LDCM0224  AC108 HEK-293T C268(0.84)  LDD0822  [11]
 LDCM0225  AC109 HEK-293T C268(0.65)  LDD0823  [11]
 LDCM0226  AC11 HEK-293T C268(1.09)  LDD0824  [11]
 LDCM0227  AC110 HEK-293T C268(0.81)  LDD0825  [11]
 LDCM0228  AC111 HEK-293T C268(0.81)  LDD0826  [11]
 LDCM0229  AC112 HEK-293T C268(0.78)  LDD0827  [11]
 LDCM0230  AC113 HEK-293T C268(1.03)  LDD0828  [11]
 LDCM0231  AC114 HEK-293T C268(1.08)  LDD0829  [11]
 LDCM0232  AC115 HEK-293T C268(1.61)  LDD0830  [11]
 LDCM0233  AC116 HEK-293T C268(0.94)  LDD0831  [11]
 LDCM0234  AC117 HEK-293T C268(0.80)  LDD0832  [11]
 LDCM0235  AC118 HEK-293T C268(1.16)  LDD0833  [11]
 LDCM0236  AC119 HEK-293T C268(1.07)  LDD0834  [11]
 LDCM0237  AC12 HEK-293T C268(0.99)  LDD0835  [11]
 LDCM0238  AC120 HEK-293T C268(0.78)  LDD0836  [11]
 LDCM0239  AC121 HEK-293T C268(0.82)  LDD0837  [11]
 LDCM0240  AC122 HEK-293T C268(1.09)  LDD0838  [11]
 LDCM0241  AC123 HEK-293T C268(1.18)  LDD0839  [11]
 LDCM0242  AC124 HEK-293T C268(1.43)  LDD0840  [11]
 LDCM0243  AC125 HEK-293T C268(0.86)  LDD0841  [11]
 LDCM0244  AC126 HEK-293T C268(0.79)  LDD0842  [11]
 LDCM0245  AC127 HEK-293T C268(1.04)  LDD0843  [11]
 LDCM0246  AC128 HEK-293T C268(1.16)  LDD0844  [11]
 LDCM0247  AC129 HEK-293T C268(1.46)  LDD0845  [11]
 LDCM0249  AC130 HEK-293T C268(1.06)  LDD0847  [11]
 LDCM0250  AC131 HEK-293T C268(0.89)  LDD0848  [11]
 LDCM0251  AC132 HEK-293T C268(0.99)  LDD0849  [11]
 LDCM0252  AC133 HEK-293T C268(1.16)  LDD0850  [11]
 LDCM0253  AC134 HEK-293T C268(1.02)  LDD0851  [11]
 LDCM0254  AC135 HEK-293T C268(1.06)  LDD0852  [11]
 LDCM0255  AC136 HEK-293T C268(1.00)  LDD0853  [11]
 LDCM0256  AC137 HEK-293T C268(0.86)  LDD0854  [11]
 LDCM0257  AC138 HEK-293T C268(0.77)  LDD0855  [11]
 LDCM0258  AC139 HEK-293T C268(0.99)  LDD0856  [11]
 LDCM0259  AC14 HEK-293T C268(0.70)  LDD0857  [11]
 LDCM0260  AC140 HEK-293T C268(1.25)  LDD0858  [11]
 LDCM0261  AC141 HEK-293T C268(1.20)  LDD0859  [11]
 LDCM0262  AC142 HEK-293T C268(1.16)  LDD0860  [11]
 LDCM0270  AC15 HEK-293T C268(0.71)  LDD0868  [11]
 LDCM0276  AC17 HEK-293T C268(1.26)  LDD0874  [11]
 LDCM0277  AC18 HEK-293T C268(1.09)  LDD0875  [11]
 LDCM0278  AC19 HEK-293T C268(1.20)  LDD0876  [11]
 LDCM0279  AC2 HEK-293T C268(1.03)  LDD0877  [11]
 LDCM0280  AC20 HEK-293T C268(1.26)  LDD0878  [11]
 LDCM0281  AC21 HEK-293T C268(1.72)  LDD0879  [11]
 LDCM0282  AC22 HEK-293T C268(1.32)  LDD0880  [11]
 LDCM0283  AC23 HEK-293T C268(0.99)  LDD0881  [11]
 LDCM0284  AC24 HEK-293T C268(1.61)  LDD0882  [11]
 LDCM0285  AC25 HEK-293T C268(1.53)  LDD0883  [11]
 LDCM0286  AC26 HEK-293T C268(1.08)  LDD0884  [11]
 LDCM0287  AC27 HEK-293T C268(1.05)  LDD0885  [11]
 LDCM0288  AC28 HEK-293T C268(1.13)  LDD0886  [11]
 LDCM0289  AC29 HEK-293T C268(1.23)  LDD0887  [11]
 LDCM0290  AC3 HEK-293T C268(1.05)  LDD0888  [11]
 LDCM0291  AC30 HEK-293T C268(1.08)  LDD0889  [11]
 LDCM0292  AC31 HEK-293T C268(1.31)  LDD0890  [11]
 LDCM0293  AC32 HEK-293T C268(1.27)  LDD0891  [11]
 LDCM0294  AC33 HEK-293T C268(1.16)  LDD0892  [11]
 LDCM0295  AC34 HEK-293T C268(1.12)  LDD0893  [11]
 LDCM0296  AC35 HEK-293T C268(1.03); C340(0.86)  LDD1535  [12]
 LDCM0297  AC36 HEK-293T C268(1.11); C340(0.93)  LDD1536  [12]
 LDCM0298  AC37 HEK-293T C268(1.08); C340(0.92)  LDD1537  [12]
 LDCM0299  AC38 HEK-293T C268(1.09); C340(0.92)  LDD1538  [12]
 LDCM0300  AC39 HEK-293T C268(1.10); C340(0.94)  LDD1539  [12]
 LDCM0301  AC4 HEK-293T C268(0.70)  LDD0899  [11]
 LDCM0302  AC40 HEK-293T C268(1.05); C340(0.81)  LDD1541  [12]
 LDCM0303  AC41 HEK-293T C268(1.11); C340(0.92)  LDD1542  [12]
 LDCM0304  AC42 HEK-293T C268(1.01); C340(1.01)  LDD1543  [12]
 LDCM0305  AC43 HEK-293T C268(1.05); C340(0.88)  LDD1544  [12]
 LDCM0306  AC44 HEK-293T C268(1.07); C340(0.91)  LDD1545  [12]
 LDCM0307  AC45 HEK-293T C268(0.98); C340(0.93)  LDD1546  [12]
 LDCM0308  AC46 HEK-293T C268(0.93)  LDD0906  [11]
 LDCM0309  AC47 HEK-293T C268(0.77)  LDD0907  [11]
 LDCM0310  AC48 HEK-293T C268(0.82)  LDD0908  [11]
 LDCM0311  AC49 HEK-293T C268(0.84)  LDD0909  [11]
 LDCM0312  AC5 HEK-293T C268(0.95)  LDD0910  [11]
 LDCM0313  AC50 HEK-293T C268(0.73)  LDD0911  [11]
 LDCM0314  AC51 HEK-293T C268(0.64)  LDD0912  [11]
 LDCM0315  AC52 HEK-293T C268(0.80)  LDD0913  [11]
 LDCM0316  AC53 HEK-293T C268(0.88)  LDD0914  [11]
 LDCM0317  AC54 HEK-293T C268(0.65)  LDD0915  [11]
 LDCM0318  AC55 HEK-293T C268(0.75)  LDD0916  [11]
 LDCM0319  AC56 HEK-293T C268(0.85)  LDD0917  [11]
 LDCM0320  AC57 HEK-293T C268(0.83)  LDD0918  [11]
 LDCM0321  AC58 HEK-293T C268(0.89)  LDD0919  [11]
 LDCM0322  AC59 HEK-293T C268(0.71)  LDD0920  [11]
 LDCM0323  AC6 HEK-293T C268(1.28)  LDD0921  [11]
 LDCM0324  AC60 HEK-293T C268(1.16)  LDD0922  [11]
 LDCM0325  AC61 HEK-293T C268(0.79)  LDD0923  [11]
 LDCM0326  AC62 HEK-293T C268(0.68)  LDD0924  [11]
 LDCM0327  AC63 HEK-293T C268(0.90)  LDD0925  [11]
 LDCM0328  AC64 HEK-293T C268(0.74)  LDD0926  [11]
 LDCM0329  AC65 HEK-293T C268(0.87)  LDD0927  [11]
 LDCM0330  AC66 HEK-293T C268(0.82)  LDD0928  [11]
 LDCM0331  AC67 HEK-293T C268(1.11)  LDD0929  [11]
 LDCM0332  AC68 HEK-293T C268(0.93)  LDD0930  [11]
 LDCM0333  AC69 HEK-293T C268(0.71)  LDD0931  [11]
 LDCM0334  AC7 HEK-293T C268(1.24)  LDD0932  [11]
 LDCM0335  AC70 HEK-293T C268(1.04)  LDD0933  [11]
 LDCM0336  AC71 HEK-293T C268(2.15)  LDD0934  [11]
 LDCM0337  AC72 HEK-293T C268(1.06)  LDD0935  [11]
 LDCM0338  AC73 HEK-293T C268(1.07)  LDD0936  [11]
 LDCM0339  AC74 HEK-293T C268(2.30)  LDD0937  [11]
 LDCM0340  AC75 HEK-293T C268(1.54)  LDD0938  [11]
 LDCM0341  AC76 HEK-293T C268(0.93)  LDD0939  [11]
 LDCM0342  AC77 HEK-293T C268(1.18)  LDD0940  [11]
 LDCM0343  AC78 HEK-293T C268(1.45)  LDD0941  [11]
 LDCM0344  AC79 HEK-293T C268(1.63)  LDD0942  [11]
 LDCM0345  AC8 HEK-293T C268(1.02)  LDD0943  [11]
 LDCM0346  AC80 HEK-293T C268(1.23)  LDD0944  [11]
 LDCM0347  AC81 HEK-293T C268(1.55)  LDD0945  [11]
 LDCM0348  AC82 HEK-293T C268(1.71)  LDD0946  [11]
 LDCM0349  AC83 HEK-293T C268(1.22)  LDD0947  [11]
 LDCM0350  AC84 HEK-293T C268(1.51)  LDD0948  [11]
 LDCM0351  AC85 HEK-293T C268(1.07)  LDD0949  [11]
 LDCM0352  AC86 HEK-293T C268(1.08)  LDD0950  [11]
 LDCM0353  AC87 HEK-293T C268(1.02)  LDD0951  [11]
 LDCM0354  AC88 HEK-293T C268(1.16)  LDD0952  [11]
 LDCM0355  AC89 HEK-293T C268(1.25)  LDD0953  [11]
 LDCM0357  AC90 HEK-293T C268(1.23)  LDD0955  [11]
 LDCM0358  AC91 HEK-293T C268(0.94)  LDD0956  [11]
 LDCM0359  AC92 HEK-293T C268(1.21)  LDD0957  [11]
 LDCM0360  AC93 HEK-293T C268(1.06)  LDD0958  [11]
 LDCM0361  AC94 HEK-293T C268(0.91)  LDD0959  [11]
 LDCM0362  AC95 HEK-293T C268(1.10)  LDD0960  [11]
 LDCM0363  AC96 HEK-293T C268(0.81)  LDD0961  [11]
 LDCM0364  AC97 HEK-293T C268(0.97)  LDD0962  [11]
 LDCM0365  AC98 HEK-293T C268(0.89)  LDD0963  [11]
 LDCM0366  AC99 HEK-293T C268(0.94)  LDD0964  [11]
 LDCM0545  Acetamide MDA-MB-231 C404(0.72)  LDD2138  [3]
 LDCM0248  AKOS034007472 HEK-293T C268(1.06)  LDD0846  [11]
 LDCM0356  AKOS034007680 HEK-293T C268(0.84)  LDD0954  [11]
 LDCM0275  AKOS034007705 HEK-293T C268(0.98)  LDD0873  [11]
 LDCM0020  ARS-1620 HCC44 C268(1.06)  LDD2171  [11]
 LDCM0632  CL-Sc Hep-G2 C404(20.00)  LDD2227  [7]
 LDCM0367  CL1 HEK-293T C268(1.77)  LDD0965  [11]
 LDCM0368  CL10 HEK-293T C268(0.90)  LDD0966  [11]
 LDCM0369  CL100 HEK-293T C268(0.82)  LDD0967  [11]
 LDCM0370  CL101 HEK-293T C268(0.84)  LDD0968  [11]
 LDCM0371  CL102 HEK-293T C268(0.74)  LDD0969  [11]
 LDCM0372  CL103 HEK-293T C268(0.78)  LDD0970  [11]
 LDCM0373  CL104 HEK-293T C268(0.74)  LDD0971  [11]
 LDCM0374  CL105 HEK-293T C268(1.15)  LDD0972  [11]
 LDCM0375  CL106 HEK-293T C268(1.90)  LDD0973  [11]
 LDCM0376  CL107 HEK-293T C268(1.11)  LDD0974  [11]
 LDCM0377  CL108 HEK-293T C268(1.11)  LDD0975  [11]
 LDCM0378  CL109 HEK-293T C268(1.36)  LDD0976  [11]
 LDCM0379  CL11 HEK-293T C268(0.86)  LDD0977  [11]
 LDCM0380  CL110 HEK-293T C268(1.24)  LDD0978  [11]
 LDCM0381  CL111 HEK-293T C268(1.48)  LDD0979  [11]
 LDCM0382  CL112 HEK-293T C268(1.53)  LDD0980  [11]
 LDCM0383  CL113 HEK-293T C268(1.26)  LDD0981  [11]
 LDCM0384  CL114 HEK-293T C268(1.18)  LDD0982  [11]
 LDCM0385  CL115 HEK-293T C268(1.31)  LDD0983  [11]
 LDCM0386  CL116 HEK-293T C268(1.18)  LDD0984  [11]
 LDCM0387  CL117 HEK-293T C268(1.07); C340(0.93)  LDD1591  [12]
 LDCM0388  CL118 HEK-293T C268(1.09); C340(0.93)  LDD1592  [12]
 LDCM0389  CL119 HEK-293T C268(1.04); C340(0.87); C347(1.05)  LDD1593  [12]
 LDCM0390  CL12 HEK-293T C268(1.09)  LDD0988  [11]
 LDCM0391  CL120 HEK-293T C268(1.06); C340(0.90)  LDD1595  [12]
 LDCM0392  CL121 HEK-293T C268(0.62)  LDD0990  [11]
 LDCM0393  CL122 HEK-293T C268(0.73)  LDD0991  [11]
 LDCM0394  CL123 HEK-293T C268(0.65)  LDD0992  [11]
 LDCM0395  CL124 HEK-293T C268(0.69)  LDD0993  [11]
 LDCM0396  CL125 HEK-293T C268(1.75)  LDD0994  [11]
 LDCM0397  CL126 HEK-293T C268(1.00)  LDD0995  [11]
 LDCM0398  CL127 HEK-293T C268(1.16)  LDD0996  [11]
 LDCM0399  CL128 HEK-293T C268(1.11)  LDD0997  [11]
 LDCM0400  CL13 HEK-293T C268(0.68)  LDD0998  [11]
 LDCM0401  CL14 HEK-293T C268(0.83)  LDD0999  [11]
 LDCM0402  CL15 HEK-293T C268(0.77)  LDD1000  [11]
 LDCM0403  CL16 HEK-293T C268(1.75)  LDD1001  [11]
 LDCM0404  CL17 HEK-293T C268(1.18)  LDD1002  [11]
 LDCM0405  CL18 HEK-293T C268(1.22)  LDD1003  [11]
 LDCM0406  CL19 HEK-293T C268(0.79)  LDD1004  [11]
 LDCM0407  CL2 HEK-293T C268(0.83)  LDD1005  [11]
 LDCM0408  CL20 HEK-293T C268(0.96)  LDD1006  [11]
 LDCM0409  CL21 HEK-293T C268(1.10)  LDD1007  [11]
 LDCM0410  CL22 HEK-293T C268(1.00)  LDD1008  [11]
 LDCM0411  CL23 HEK-293T C268(0.71)  LDD1009  [11]
 LDCM0412  CL24 HEK-293T C268(1.11)  LDD1010  [11]
 LDCM0413  CL25 HEK-293T C268(1.44)  LDD1011  [11]
 LDCM0414  CL26 HEK-293T C268(1.07)  LDD1012  [11]
 LDCM0415  CL27 HEK-293T C268(0.97)  LDD1013  [11]
 LDCM0416  CL28 HEK-293T C268(1.11)  LDD1014  [11]
 LDCM0417  CL29 HEK-293T C268(0.97)  LDD1015  [11]
 LDCM0418  CL3 HEK-293T C268(1.37)  LDD1016  [11]
 LDCM0419  CL30 HEK-293T C268(1.01)  LDD1017  [11]
 LDCM0420  CL31 HEK-293T C268(1.16)  LDD1018  [11]
 LDCM0421  CL32 HEK-293T C268(1.09)  LDD1019  [11]
 LDCM0422  CL33 HEK-293T C268(1.18)  LDD1020  [11]
 LDCM0423  CL34 HEK-293T C268(0.73)  LDD1021  [11]
 LDCM0424  CL35 HEK-293T C268(0.93)  LDD1022  [11]
 LDCM0425  CL36 HEK-293T C268(0.82)  LDD1023  [11]
 LDCM0426  CL37 HEK-293T C268(0.79)  LDD1024  [11]
 LDCM0428  CL39 HEK-293T C268(0.73)  LDD1026  [11]
 LDCM0429  CL4 HEK-293T C268(0.79)  LDD1027  [11]
 LDCM0430  CL40 HEK-293T C268(0.69)  LDD1028  [11]
 LDCM0431  CL41 HEK-293T C268(0.94)  LDD1029  [11]
 LDCM0432  CL42 HEK-293T C268(0.87)  LDD1030  [11]
 LDCM0433  CL43 HEK-293T C268(0.75)  LDD1031  [11]
 LDCM0434  CL44 HEK-293T C268(0.88)  LDD1032  [11]
 LDCM0435  CL45 HEK-293T C268(0.72)  LDD1033  [11]
 LDCM0436  CL46 HEK-293T C268(1.41)  LDD1034  [11]
 LDCM0437  CL47 HEK-293T C268(1.01)  LDD1035  [11]
 LDCM0438  CL48 HEK-293T C268(1.27)  LDD1036  [11]
 LDCM0439  CL49 HEK-293T C268(0.90)  LDD1037  [11]
 LDCM0440  CL5 HEK-293T C268(0.83)  LDD1038  [11]
 LDCM0441  CL50 HEK-293T C268(0.87)  LDD1039  [11]
 LDCM0442  CL51 HEK-293T C268(0.98)  LDD1040  [11]
 LDCM0443  CL52 HEK-293T C268(0.82)  LDD1041  [11]
 LDCM0444  CL53 HEK-293T C268(0.74)  LDD1042  [11]
 LDCM0445  CL54 HEK-293T C268(0.54)  LDD1043  [11]
 LDCM0446  CL55 HEK-293T C268(0.72)  LDD1044  [11]
 LDCM0447  CL56 HEK-293T C268(0.67)  LDD1045  [11]
 LDCM0448  CL57 HEK-293T C268(0.85)  LDD1046  [11]
 LDCM0449  CL58 HEK-293T C268(0.71)  LDD1047  [11]
 LDCM0450  CL59 HEK-293T C268(0.80)  LDD1048  [11]
 LDCM0451  CL6 HEK-293T C268(0.94)  LDD1049  [11]
 LDCM0452  CL60 HEK-293T C268(0.84)  LDD1050  [11]
 LDCM0453  CL61 HEK-293T C268(1.04); C340(0.89)  LDD1656  [12]
 LDCM0454  CL62 HEK-293T C268(1.02); C340(0.85)  LDD1657  [12]
 LDCM0455  CL63 HEK-293T C268(1.04); C340(0.79); C347(1.17)  LDD1658  [12]
 LDCM0456  CL64 HEK-293T C268(1.00); C340(0.86)  LDD1659  [12]
 LDCM0457  CL65 HEK-293T C268(1.11); C340(0.92)  LDD1660  [12]
 LDCM0458  CL66 HEK-293T C268(1.04); C340(0.99)  LDD1661  [12]
 LDCM0459  CL67 HEK-293T C268(1.03); C340(0.93)  LDD1662  [12]
 LDCM0460  CL68 HEK-293T C268(1.09); C340(0.95)  LDD1663  [12]
 LDCM0461  CL69 HEK-293T C268(1.05); C340(0.98)  LDD1664  [12]
 LDCM0462  CL7 HEK-293T C268(0.82)  LDD1060  [11]
 LDCM0463  CL70 HEK-293T C268(1.06); C340(1.03)  LDD1666  [12]
 LDCM0464  CL71 HEK-293T C268(1.06); C340(1.12)  LDD1667  [12]
 LDCM0465  CL72 HEK-293T C268(1.18); C340(0.96)  LDD1668  [12]
 LDCM0466  CL73 HEK-293T C268(0.98); C340(0.91)  LDD1669  [12]
 LDCM0467  CL74 HEK-293T C268(1.01); C340(0.94)  LDD1670  [12]
 LDCM0469  CL76 HEK-293T C268(1.00); C340(0.93)  LDD1672  [12]
 LDCM0470  CL77 HEK-293T C268(0.94); C340(0.92)  LDD1673  [12]
 LDCM0471  CL78 HEK-293T C268(1.03); C340(0.98)  LDD1674  [12]
 LDCM0472  CL79 HEK-293T C268(1.00); C340(0.93)  LDD1675  [12]
 LDCM0473  CL8 HEK-293T C268(0.86); C340(1.04)  LDD1676  [12]
 LDCM0474  CL80 HEK-293T C268(1.07); C340(0.99)  LDD1677  [12]
 LDCM0475  CL81 HEK-293T C268(1.10); C340(1.01)  LDD1678  [12]
 LDCM0476  CL82 HEK-293T C268(1.07); C340(0.98)  LDD1679  [12]
 LDCM0477  CL83 HEK-293T C268(1.03); C340(1.03)  LDD1680  [12]
 LDCM0478  CL84 HEK-293T C268(1.02); C340(0.96)  LDD1681  [12]
 LDCM0479  CL85 HEK-293T C268(0.92); C340(0.86)  LDD1682  [12]
 LDCM0480  CL86 HEK-293T C268(1.01); C340(0.90)  LDD1683  [12]
 LDCM0481  CL87 HEK-293T C268(1.02); C340(0.74); C347(0.97)  LDD1684  [12]
 LDCM0482  CL88 HEK-293T C268(0.99); C340(0.99)  LDD1685  [12]
 LDCM0483  CL89 HEK-293T C268(1.07); C340(0.84)  LDD1686  [12]
 LDCM0484  CL9 HEK-293T C268(1.03); C340(1.04)  LDD1687  [12]
 LDCM0485  CL90 HEK-293T C268(0.93); C340(0.89)  LDD1688  [12]
 LDCM0486  CL91 HEK-293T C268(1.38)  LDD1084  [11]
 LDCM0487  CL92 HEK-293T C268(1.02)  LDD1085  [11]
 LDCM0488  CL93 HEK-293T C268(0.87)  LDD1086  [11]
 LDCM0489  CL94 HEK-293T C268(0.99)  LDD1087  [11]
 LDCM0490  CL95 HEK-293T C268(0.85)  LDD1088  [11]
 LDCM0491  CL96 HEK-293T C268(0.98)  LDD1089  [11]
 LDCM0492  CL97 HEK-293T C268(0.90)  LDD1090  [11]
 LDCM0493  CL98 HEK-293T C268(0.72)  LDD1091  [11]
 LDCM0494  CL99 HEK-293T C268(0.86)  LDD1092  [11]
 LDCM0495  E2913 HEK-293T C268(1.05); C340(0.99); C347(1.05)  LDD1698  [12]
 LDCM0468  Fragment33 HEK-293T C268(0.98); C340(0.79); C347(1.06)  LDD1671  [12]
 LDCM0427  Fragment51 HEK-293T C268(0.79)  LDD1025  [11]
 LDCM0116  HHS-0101 DM93 Y92(3.70)  LDD0264  [2]
 LDCM0117  HHS-0201 DM93 Y92(3.47)  LDD0265  [2]
 LDCM0118  HHS-0301 DM93 Y92(3.75)  LDD0266  [2]
 LDCM0119  HHS-0401 DM93 Y92(4.06)  LDD0267  [2]
 LDCM0120  HHS-0701 DM93 Y92(1.76)  LDD0268  [2]
 LDCM0022  KB02 HEK-293T C268(0.91); C340(1.01)  LDD1492  [12]
 LDCM0023  KB03 Jurkat C340(4.26)  LDD0209  [1]
 LDCM0024  KB05 COLO792 C268(1.77)  LDD3310  [13]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C404(1.04)  LDD2093  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C404(1.03)  LDD2099  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C404(1.09)  LDD2107  [3]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C404(0.76)  LDD2120  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C404(0.80)  LDD2127  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C404(0.69)  LDD2129  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C404(0.58)  LDD2140  [3]
 LDCM0021  THZ1 HCT 116 C268(1.06)  LDD2173  [11]

References

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2 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
9 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
10 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
11 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840