Details of the Target

General Information of Target

Target ID LDTP15003
Target Name CSC1-like protein 2 (TMEM63B)
Gene Name TMEM63B
Gene ID 55362
Synonyms
C6orf110; CSC1-like protein 2; Transmembrane protein 63B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAQVEKRGGLLRKSSASKKPLKEKVVLMYDEIFMTEDPSKCSPRFWEELFLMKVNLEYLE
GKLESLDGEELMKIKDNINCLFQHCIQALGEEHPIRVVNALQTLCALIRGVHQKNKSTSG
FDIINMLMGFDKAELCMKNLMESLDSLLCAEGSESLKSLCLKLLLCLVTVTDNISQNTIL
EYVMINSIFEAILQILSHPPSRREHGYDAVVLLALLVNYRKYESVNPYIVKLSIVDDEAT
LNGMGLVIAQALSEYNRQYKDKEEEHQSGFFSALTNMVGSMFIADAHEKISVQTNEAILL
ALYEAVHLNRNFITVLAQSHPEMGLVTTPVSPAPTTPVTPLGTTPPSSDVISSVELPLDA
DVQTSNLLITFLKYSSIVMQDTKDEHRLHSGKLCLIILTCIAEDQYANAFLHDDNMNFRV
NLHRMPMRHRKKAADKNLPCRPLVCAVLDLMVEFIVTHMMKEFPMDLYIRCIQVVHKLLC
YQKKCRVRLHYTWRELWSALINLLKFLMSNETVLLAKHNIFTLALMIVNLFNMFITYGDT
FLPTPSSYDELYYEIIRMHQSFDNLYSMVLRLSTNAGQWKEAASKVTHALVNIRAIINHF
NPKIESYAAVNHISQLSEEQVLEVVRANYDTLTLKLQDGLDQYERYSEQHKEAAFFKELV
RSISTNVRRNLAFHTLSQEVLLKEFSTIS
Target Bioclass
Transporter and channel
Family
CSC1 (TC 1.A.17) family
Subcellular location
Cell membrane
Function
Acts as an osmosensitive calcium-permeable cation channel. Mechanosensitive ion channel that converts mechanical stimuli into a flow of ion. Acts as an inner ear osmosensor, essential for normal hearing and survival of inner ear outer hair cells (OHCs). Mediates calcium-dependent regulatory volume decrease in OHCs which is necessary for their survival. Required for the maintenance of the morphological integrity of OHCs under hypotonic conditions. Mediates hypo-osmolarity-induced calcium influx, leading to activation of calcium-dependent potassium channels required for the maintenance of OHC morphology.
Uniprot ID
Q5T3F8
Ensemble ID
ENST00000259746.13
HGNC ID
HGNC:17735

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.N368D .
HT SNV: p.H422R .
KMS27 SNV: p.A212T .
MCC13 Substitution: p.E85K; p.L168F .
NCIH2172 SNV: p.Y594C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K233(10.00); K239(0.73); K249(9.99)  LDD0277  [1]
IPM
 Probe Info  		N.A.  LDD0241  [2]
DBIA
 Probe Info  		C23(1.60)  LDD0625  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C275(0.97)  LDD1507  [4]
 LDCM0215  AC10 HEK-293T C275(0.91)  LDD1508  [4]
 LDCM0226  AC11 HEK-293T C275(1.00); C267(1.01)  LDD1509  [4]
 LDCM0237  AC12 HEK-293T C275(1.14); C267(0.93); C23(0.94)  LDD1510  [4]
 LDCM0259  AC14 HEK-293T C275(1.02); C267(0.86)  LDD1512  [4]
 LDCM0270  AC15 HEK-293T C267(1.05)  LDD1513  [4]
 LDCM0276  AC17 HEK-293T C275(0.88)  LDD1515  [4]
 LDCM0277  AC18 HEK-293T C275(0.90)  LDD1516  [4]
 LDCM0278  AC19 HEK-293T C275(0.89); C267(0.90)  LDD1517  [4]
 LDCM0279  AC2 HEK-293T C275(0.94)  LDD1518  [4]
 LDCM0280  AC20 HEK-293T C275(0.97); C267(0.99); C23(0.97)  LDD1519  [4]
 LDCM0281  AC21 HEK-293T C275(0.99); C267(1.15)  LDD1520  [4]
 LDCM0282  AC22 HEK-293T C275(0.96); C267(0.98)  LDD1521  [4]
 LDCM0283  AC23 HEK-293T C267(0.93)  LDD1522  [4]
 LDCM0284  AC24 HEK-293T C275(0.98); C267(0.93); C23(0.96)  LDD1523  [4]
 LDCM0285  AC25 HEK-293T C275(0.92)  LDD1524  [4]
 LDCM0286  AC26 HEK-293T C275(0.95)  LDD1525  [4]
 LDCM0287  AC27 HEK-293T C275(1.06); C267(0.96)  LDD1526  [4]
 LDCM0288  AC28 HEK-293T C275(0.97); C267(1.04); C23(1.18)  LDD1527  [4]
 LDCM0289  AC29 HEK-293T C275(0.93); C267(1.00)  LDD1528  [4]
 LDCM0290  AC3 HEK-293T C275(0.99); C267(0.99)  LDD1529  [4]
 LDCM0291  AC30 HEK-293T C275(0.98); C267(1.03)  LDD1530  [4]
 LDCM0292  AC31 HEK-293T C267(0.98)  LDD1531  [4]
 LDCM0293  AC32 HEK-293T C275(0.99); C267(1.04); C23(0.93)  LDD1532  [4]
 LDCM0294  AC33 HEK-293T C275(0.93)  LDD1533  [4]
 LDCM0295  AC34 HEK-293T C275(0.95)  LDD1534  [4]
 LDCM0296  AC35 HEK-293T C275(1.00); C267(0.94)  LDD1535  [4]
 LDCM0297  AC36 HEK-293T C275(1.06); C267(0.94); C23(0.95)  LDD1536  [4]
 LDCM0298  AC37 HEK-293T C275(1.06); C267(1.07)  LDD1537  [4]
 LDCM0299  AC38 HEK-293T C275(1.13); C267(1.03)  LDD1538  [4]
 LDCM0300  AC39 HEK-293T C267(1.03)  LDD1539  [4]
 LDCM0301  AC4 HEK-293T C275(0.97); C267(0.89); C23(0.93)  LDD1540  [4]
 LDCM0302  AC40 HEK-293T C275(0.95); C267(0.96); C23(1.11)  LDD1541  [4]
 LDCM0303  AC41 HEK-293T C275(0.93)  LDD1542  [4]
 LDCM0304  AC42 HEK-293T C275(0.83)  LDD1543  [4]
 LDCM0305  AC43 HEK-293T C275(0.94); C267(0.94)  LDD1544  [4]
 LDCM0306  AC44 HEK-293T C275(0.99); C267(0.95); C23(1.09)  LDD1545  [4]
 LDCM0307  AC45 HEK-293T C275(0.97); C267(1.08)  LDD1546  [4]
 LDCM0308  AC46 HCT 116 C23(1.60)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C23(0.85)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C23(0.99)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C23(0.85)  LDD0628  [3]
 LDCM0312  AC5 HEK-293T C275(0.99); C267(1.04)  LDD1551  [4]
 LDCM0313  AC50 HCT 116 C23(1.18)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C23(1.56)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C23(1.03)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C23(1.10)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C23(1.49)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C23(1.10)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C23(1.34)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C23(1.16)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C23(1.51)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C23(0.97)  LDD0639  [3]
 LDCM0323  AC6 HEK-293T C275(1.06); C267(0.89)  LDD1562  [4]
 LDCM0324  AC60 HCT 116 C23(1.05)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C23(1.18)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C23(1.32)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C23(1.00)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C23(1.07)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C23(1.36)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C23(2.37)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C23(1.05)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C23(1.24)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C23(1.22)  LDD0650  [3]
 LDCM0334  AC7 HEK-293T C267(0.91)  LDD1568  [4]
 LDCM0335  AC70 HCT 116 C23(0.93)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C23(0.98)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C23(1.21)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C23(1.05)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C23(1.15)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C23(1.06)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C23(0.98)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C23(1.08)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C23(1.15)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C23(1.13)  LDD0661  [3]
 LDCM0345  AC8 HEK-293T C275(0.94); C267(1.13); C23(1.00)  LDD1569  [4]
 LDCM0346  AC80 HCT 116 C23(1.09)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C23(0.91)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C23(1.62)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C23(1.42)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C23(1.57)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C23(1.43)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C23(1.16)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C23(1.29)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C23(1.46)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C23(1.26)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C23(1.18)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C23(1.55)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C23(1.65)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C23(1.49)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C23(1.15)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C23(1.37)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C23(1.17)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C23(1.42)  LDD0681  [3]
 LDCM0248  AKOS034007472 HEK-293T C275(1.05); C267(0.94)  LDD1511  [4]
 LDCM0356  AKOS034007680 HEK-293T C275(0.97)  LDD1570  [4]
 LDCM0275  AKOS034007705 HEK-293T C275(0.91); C267(0.99); C23(0.98)  LDD1514  [4]
 LDCM0020  ARS-1620 HCC44 C23(1.06)  LDD2171  [3]
 LDCM0367  CL1 HEK-293T C275(0.90)  LDD1571  [4]
 LDCM0368  CL10 HEK-293T C275(1.60); C267(1.15)  LDD1572  [4]
 LDCM0369  CL100 HEK-293T C275(0.96); C267(0.99); C23(0.96)  LDD1573  [4]
 LDCM0370  CL101 HEK-293T C275(0.92)  LDD1574  [4]
 LDCM0371  CL102 HEK-293T C275(0.95); C267(1.00)  LDD1575  [4]
 LDCM0372  CL103 HEK-293T C275(1.01)  LDD1576  [4]
 LDCM0373  CL104 HEK-293T C275(1.04); C267(1.00); C23(1.07)  LDD1577  [4]
 LDCM0374  CL105 HEK-293T C275(0.86)  LDD1578  [4]
 LDCM0375  CL106 HEK-293T C275(0.98); C267(0.99)  LDD1579  [4]
 LDCM0376  CL107 HEK-293T C275(1.00)  LDD1580  [4]
 LDCM0377  CL108 HEK-293T C275(0.98); C267(1.02); C23(1.07)  LDD1581  [4]
 LDCM0378  CL109 HEK-293T C275(0.99)  LDD1582  [4]
 LDCM0379  CL11 HEK-293T C267(1.63)  LDD1583  [4]
 LDCM0380  CL110 HEK-293T C275(0.95); C267(1.07)  LDD1584  [4]
 LDCM0381  CL111 HEK-293T C275(1.03)  LDD1585  [4]
 LDCM0382  CL112 HEK-293T C275(0.90); C267(1.08); C23(1.16)  LDD1586  [4]
 LDCM0383  CL113 HEK-293T C275(0.98)  LDD1587  [4]
 LDCM0384  CL114 HEK-293T C275(1.13); C267(0.95)  LDD1588  [4]
 LDCM0385  CL115 HEK-293T C275(1.02)  LDD1589  [4]
 LDCM0386  CL116 HEK-293T C275(0.98); C267(0.90); C23(1.17)  LDD1590  [4]
 LDCM0387  CL117 HEK-293T C275(0.97)  LDD1591  [4]
 LDCM0388  CL118 HEK-293T C275(0.96); C267(1.01)  LDD1592  [4]
 LDCM0389  CL119 HEK-293T C275(1.02)  LDD1593  [4]
 LDCM0390  CL12 HEK-293T C275(1.42); C267(1.28); C23(1.02)  LDD1594  [4]
 LDCM0391  CL120 HEK-293T C275(1.03); C267(0.93); C23(1.12)  LDD1595  [4]
 LDCM0392  CL121 HCT 116 C23(1.09)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C23(1.01)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C23(1.90)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C23(1.12)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C23(1.01)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C23(0.99)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C23(1.09)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C23(1.06)  LDD0716  [3]
 LDCM0400  CL13 HEK-293T C275(0.99)  LDD1604  [4]
 LDCM0401  CL14 HEK-293T C275(1.14); C267(1.05)  LDD1605  [4]
 LDCM0402  CL15 HEK-293T C275(1.13)  LDD1606  [4]
 LDCM0403  CL16 HEK-293T C275(1.11); C267(1.02); C23(1.15)  LDD1607  [4]
 LDCM0404  CL17 HEK-293T C275(1.06)  LDD1608  [4]
 LDCM0405  CL18 HEK-293T C275(1.28)  LDD1609  [4]
 LDCM0406  CL19 HEK-293T C275(1.34); C267(1.10)  LDD1610  [4]
 LDCM0407  CL2 HEK-293T C275(1.08); C267(1.05)  LDD1611  [4]
 LDCM0408  CL20 HEK-293T C275(1.62); C267(1.25); C23(1.05)  LDD1612  [4]
 LDCM0409  CL21 HEK-293T C275(1.39); C267(1.28)  LDD1613  [4]
 LDCM0410  CL22 HEK-293T C275(1.85); C267(1.43)  LDD1614  [4]
 LDCM0411  CL23 HEK-293T C267(1.57)  LDD1615  [4]
 LDCM0412  CL24 HEK-293T C275(1.81); C267(1.46); C23(1.18)  LDD1616  [4]
 LDCM0413  CL25 HEK-293T C275(0.92)  LDD1617  [4]
 LDCM0414  CL26 HEK-293T C275(0.98); C267(1.07)  LDD1618  [4]
 LDCM0415  CL27 HEK-293T C275(0.98)  LDD1619  [4]
 LDCM0416  CL28 HEK-293T C275(0.97); C267(1.08); C23(1.21)  LDD1620  [4]
 LDCM0417  CL29 HEK-293T C275(1.07)  LDD1621  [4]
 LDCM0418  CL3 HEK-293T C275(1.24)  LDD1622  [4]
 LDCM0419  CL30 HEK-293T C275(0.97)  LDD1623  [4]
 LDCM0420  CL31 HCT 116 C23(1.18)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C23(0.36)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C23(0.63)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C23(0.64)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C23(0.56)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C23(0.87)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C23(0.48)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C23(0.58)  LDD0745  [3]
 LDCM0429  CL4 HEK-293T C275(1.02); C267(1.16); C23(1.35)  LDD1633  [4]
 LDCM0430  CL40 HCT 116 C23(0.79)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C23(0.50)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C23(0.39)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C23(0.67)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C23(0.46)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C23(0.50)  LDD0752  [3]
 LDCM0436  CL46 HEK-293T C275(1.89); C267(1.11)  LDD1640  [4]
 LDCM0437  CL47 HEK-293T C267(1.53)  LDD1641  [4]
 LDCM0438  CL48 HEK-293T C275(1.43); C267(1.30); C23(0.92)  LDD1642  [4]
 LDCM0439  CL49 HEK-293T C275(0.97)  LDD1643  [4]
 LDCM0440  CL5 HEK-293T C275(1.10)  LDD1644  [4]
 LDCM0441  CL50 HEK-293T C275(1.06); C267(1.04)  LDD1645  [4]
 LDCM0443  CL52 HEK-293T C275(0.94); C267(1.00); C23(1.09)  LDD1646  [4]
 LDCM0444  CL53 HEK-293T C275(0.98)  LDD1647  [4]
 LDCM0445  CL54 HEK-293T C275(1.05)  LDD1648  [4]
 LDCM0446  CL55 HEK-293T C275(1.16); C267(1.15)  LDD1649  [4]
 LDCM0447  CL56 HEK-293T C275(1.19); C267(1.20); C23(1.05)  LDD1650  [4]
 LDCM0448  CL57 HEK-293T C275(1.27); C267(1.26)  LDD1651  [4]
 LDCM0449  CL58 HEK-293T C275(1.78); C267(1.12)  LDD1652  [4]
 LDCM0450  CL59 HEK-293T C267(1.52)  LDD1653  [4]
 LDCM0451  CL6 HEK-293T C275(0.98)  LDD1654  [4]
 LDCM0452  CL60 HEK-293T C275(1.50); C267(1.36); C23(1.12)  LDD1655  [4]
 LDCM0453  CL61 HEK-293T C275(0.97)  LDD1656  [4]
 LDCM0454  CL62 HEK-293T C275(0.97); C267(1.02)  LDD1657  [4]
 LDCM0455  CL63 HEK-293T C275(1.08)  LDD1658  [4]
 LDCM0456  CL64 HEK-293T C275(0.96); C267(1.08); C23(1.22)  LDD1659  [4]
 LDCM0457  CL65 HEK-293T C275(0.90)  LDD1660  [4]
 LDCM0458  CL66 HEK-293T C275(0.96)  LDD1661  [4]
 LDCM0459  CL67 HEK-293T C275(1.13); C267(1.00)  LDD1662  [4]
 LDCM0460  CL68 HEK-293T C275(1.17); C267(1.32); C23(1.04)  LDD1663  [4]
 LDCM0461  CL69 HEK-293T C275(1.25); C267(1.11)  LDD1664  [4]
 LDCM0462  CL7 HEK-293T C275(1.20); C267(1.08)  LDD1665  [4]
 LDCM0463  CL70 HEK-293T C275(1.51); C267(1.03)  LDD1666  [4]
 LDCM0464  CL71 HEK-293T C267(1.36)  LDD1667  [4]
 LDCM0465  CL72 HEK-293T C275(1.48); C267(1.29); C23(1.18)  LDD1668  [4]
 LDCM0466  CL73 HEK-293T C275(0.91)  LDD1669  [4]
 LDCM0467  CL74 HEK-293T C275(1.07); C267(1.05)  LDD1670  [4]
 LDCM0469  CL76 HEK-293T C275(1.06); C267(0.97); C23(1.06)  LDD1672  [4]
 LDCM0470  CL77 HEK-293T C275(0.99)  LDD1673  [4]
 LDCM0471  CL78 HEK-293T C275(1.05)  LDD1674  [4]
 LDCM0472  CL79 HEK-293T C275(1.02); C267(1.23)  LDD1675  [4]
 LDCM0473  CL8 HEK-293T C275(1.46); C267(1.41); C23(3.07)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C275(1.27); C267(1.17); C23(0.98)  LDD1677  [4]
 LDCM0475  CL81 HEK-293T C275(1.28); C267(1.32)  LDD1678  [4]
 LDCM0476  CL82 HEK-293T C275(1.34); C267(1.02)  LDD1679  [4]
 LDCM0477  CL83 HEK-293T C267(1.29)  LDD1680  [4]
 LDCM0478  CL84 HEK-293T C275(1.06); C267(1.18); C23(1.14)  LDD1681  [4]
 LDCM0479  CL85 HEK-293T C275(1.00)  LDD1682  [4]
 LDCM0480  CL86 HEK-293T C275(1.07); C267(1.05)  LDD1683  [4]
 LDCM0481  CL87 HEK-293T C275(1.02)  LDD1684  [4]
 LDCM0482  CL88 HEK-293T C275(0.94); C267(1.03); C23(1.06)  LDD1685  [4]
 LDCM0483  CL89 HEK-293T C275(1.01)  LDD1686  [4]
 LDCM0484  CL9 HEK-293T C275(1.31); C267(1.41)  LDD1687  [4]
 LDCM0485  CL90 HEK-293T C275(1.33)  LDD1688  [4]
 LDCM0486  CL91 HEK-293T C275(1.21); C267(0.95)  LDD1689  [4]
 LDCM0487  CL92 HEK-293T C275(1.25); C267(0.99); C23(1.31)  LDD1690  [4]
 LDCM0488  CL93 HEK-293T C275(1.22); C267(1.21)  LDD1691  [4]
 LDCM0489  CL94 HEK-293T C275(1.38); C267(0.97)  LDD1692  [4]
 LDCM0490  CL95 HEK-293T C267(1.33)  LDD1693  [4]
 LDCM0491  CL96 HEK-293T C275(1.22); C267(1.16); C23(1.46)  LDD1694  [4]
 LDCM0492  CL97 HEK-293T C275(0.95)  LDD1695  [4]
 LDCM0493  CL98 HEK-293T C275(1.08); C267(1.03)  LDD1696  [4]
 LDCM0494  CL99 HEK-293T C275(0.96)  LDD1697  [4]
 LDCM0495  E2913 HEK-293T C275(1.00)  LDD1698  [4]
 LDCM0468  Fragment33 HEK-293T C275(1.02)  LDD1671  [4]
 LDCM0427  Fragment51 HCT 116 C23(0.57)  LDD0744  [3]
 LDCM0022  KB02 HEK-293T C267(0.93); C275(1.03)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C267(0.98); C275(1.10)  LDD1497  [4]
 LDCM0024  KB05 RAW264.7 C23(5.39)  LDD3329  [5]
 LDCM0021  THZ1 HCT 116 C23(1.06)  LDD2173  [3]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840