Details of the Target

General Information of Target

Target ID LDTP14962
Target Name Zinc finger protein 628 (ZNF628)
Gene Name ZNF628
Gene ID 89887
Synonyms
Zinc finger protein 628
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRATAIVLLLALTLATMFSIECAKQTKQMVDCSHYKKLPPGQQRFCHHMYDPICGSDGKT
YKNDCFFCSKVKKTDGTLKFVHFGKC
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function Transcriptional activator. Binds DNA on GT-box consensus sequence 5'-TTGGTT-3'. Plays a role in spermiogenesis.
Uniprot ID
Q5EBL2
Ensemble ID
ENST00000598519.2
HGNC ID
HGNC:28054

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C150(1.28); C153(1.28)  LDD0613  [1]
IPM
 Probe Info  		N.A.  LDD0147  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0296  AC35 HCT 116 C150(1.28); C153(1.28)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C150(0.98); C153(0.98)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C150(0.88); C153(0.88)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C150(1.08); C153(1.08)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C150(1.36); C153(1.36)  LDD0617  [1]
 LDCM0302  AC40 HCT 116 C150(0.83); C153(0.83)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C150(0.70); C153(0.70)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C150(0.86); C153(0.86)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C150(0.82); C153(0.82)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C150(0.93); C153(0.93)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C150(0.87); C153(0.87)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C150(1.24); C153(1.24)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C150(1.24); C153(1.24)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C150(1.29); C153(1.29)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C150(0.84); C153(0.84)  LDD0628  [1]
 LDCM0313  AC50 HCT 116 C150(0.75); C153(0.75)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C150(0.79); C153(0.79)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C150(0.90); C153(0.90)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C150(0.85); C153(0.85)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C150(1.14); C153(1.14)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C150(1.25); C153(1.25)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C150(1.00); C153(1.00)  LDD0636  [1]
 LDCM0387  CL117 HCT 116 C150(0.92); C153(0.92)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C150(0.92); C153(0.92)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C150(1.25); C153(1.25)  LDD0706  [1]
 LDCM0391  CL120 HCT 116 C150(0.95); C153(0.95)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C150(1.15); C153(1.15)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C150(1.05); C153(1.05)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C150(1.45); C153(1.45)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C150(1.13); C153(1.13)  LDD0712  [1]
 LDCM0403  CL16 HCT 116 C150(1.15); C153(1.15)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C150(0.96); C153(0.96)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C150(1.04); C153(1.04)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C150(1.17); C153(1.17)  LDD0723  [1]
 LDCM0408  CL20 HCT 116 C150(0.96); C153(0.96)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C150(1.07); C153(1.07)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C150(0.98); C153(0.98)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C150(0.78); C153(0.78)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C150(2.09); C153(2.09)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C150(1.13); C153(1.13)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C150(1.19); C153(1.19)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C150(1.69); C153(1.69)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C150(1.08); C153(1.08)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C150(1.37); C153(1.37)  LDD0734  [1]
 LDCM0419  CL30 HCT 116 C150(1.12); C153(1.12)  LDD0736  [1]
 LDCM0421  CL32 HCT 116 C150(1.24); C153(1.24)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C150(0.93); C153(0.93)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C150(0.93); C153(0.93)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C150(1.49); C153(1.49)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C150(0.88); C153(0.88)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C150(1.49); C153(1.49)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C150(1.04); C153(1.04)  LDD0745  [1]
 LDCM0430  CL40 HCT 116 C150(0.86); C153(0.86)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C150(0.77); C153(0.77)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C150(0.93); C153(0.93)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C150(0.93); C153(0.93)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C150(1.23); C153(1.23)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C150(1.39); C153(1.39)  LDD0752  [1]
 LDCM0436  CL46 HCT 116 C150(1.15); C153(1.15)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C150(1.30); C153(1.30)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C150(1.49); C153(1.49)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C150(1.13); C153(1.13)  LDD0756  [1]
 LDCM0441  CL50 HCT 116 C150(0.74); C153(0.74)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C150(1.62); C153(1.62)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C150(0.87); C153(0.87)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C150(1.03); C153(1.03)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C150(0.78); C153(0.78)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C150(1.19); C153(1.19)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C150(0.84); C153(0.84)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C150(1.09); C153(1.09)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C150(0.78); C153(0.78)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C150(0.86); C153(0.86)  LDD0767  [1]
 LDCM0452  CL60 HCT 116 C150(0.77); C153(0.77)  LDD0769  [1]
 LDCM0469  CL76 HCT 116 C150(0.73); C153(0.73)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C150(0.90); C153(0.90)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C150(0.93); C153(0.93)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C150(0.95); C153(0.95)  LDD0789  [1]
 LDCM0474  CL80 HCT 116 C150(1.15); C153(1.15)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C150(0.75); C153(0.75)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C150(1.03); C153(1.03)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C150(0.95); C153(0.95)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C150(0.71); C153(0.71)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C150(0.70); C153(0.70)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C150(0.85); C153(0.85)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C150(1.21); C153(1.21)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C150(1.11); C153(1.11)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C150(0.99); C153(0.99)  LDD0800  [1]
 LDCM0485  CL90 HCT 116 C150(1.06); C153(1.06)  LDD0802  [1]
 LDCM0427  Fragment51 HCT 116 C150(1.21); C153(1.21)  LDD0744  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Exocyst complex component 8 (EXOC8) EXO84 family Q8IYI6
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255