Details of the Target

General Information of Target

Target ID LDTP14530
Target Name Ornithine decarboxylase antizyme 2 (OAZ2)
Gene Name OAZ2
Gene ID 4947
Synonyms
Ornithine decarboxylase antizyme 2; AZ2; ODC-Az 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSALTRLASFARVGGRLFRSGCARTAGDGGVRHAGGGVHIEPRYRQFPQLTRSQVFQSEF
FSGLMWFWILWRFWHDSEEVLGHFPYPDPSQWTDEELGIPPDDED
Target Bioclass
Other
Family
ODC antizyme family
Subcellular location
Nucleus
Function
Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity. Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol.
Uniprot ID
O95190
Ensemble ID
ENST00000326005.10
HGNC ID
HGNC:8096

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCC1419 SNV: p.C21R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C138(1.45)  LDD0531  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C138(1.45)  LDD0531  [1]
 LDCM0215  AC10 HCT 116 C138(1.01)  LDD0532  [1]
 LDCM0226  AC11 HCT 116 C138(0.95)  LDD0543  [1]
 LDCM0237  AC12 HCT 116 C138(0.84)  LDD0554  [1]
 LDCM0259  AC14 HCT 116 C138(0.99)  LDD0576  [1]
 LDCM0263  AC143 HCT 116 C138(1.16)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C138(1.46)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C138(1.25)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C138(1.48)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C138(2.17)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C138(2.28)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C138(1.51)  LDD0586  [1]
 LDCM0270  AC15 HCT 116 C138(0.95)  LDD0587  [1]
 LDCM0271  AC150 HCT 116 C138(1.26)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C138(1.33)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C138(1.63)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C138(2.54)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C138(1.40)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C138(1.68)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C138(1.11)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C138(1.21)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C138(1.17)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C138(1.16)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C138(1.15)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C138(0.88)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C138(1.06)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C138(0.96)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C138(0.87)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C138(0.98)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C138(1.23)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C138(1.05)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C138(1.30)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C138(1.35)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C138(1.38)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C138(1.33)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C138(0.97)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C138(1.33)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C138(1.54)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C138(1.54)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C138(1.72)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C138(1.72)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C138(0.89)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C138(0.82)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C138(0.87)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C138(1.02)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C138(1.01)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C138(0.87)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C138(1.14)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C138(0.77)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C138(1.01)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C138(1.34)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C138(1.02)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C138(1.26)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C138(1.05)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C138(1.03)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C138(1.11)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C138(1.51)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C138(0.98)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C138(1.47)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C138(0.88)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C138(1.01)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C138(1.23)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C138(1.19)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C138(1.29)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C138(1.89)  LDD0636  [1]
 LDCM0320  AC57 HCT 116 C138(1.10)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C138(1.38)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C138(1.41)  LDD0639  [1]
 LDCM0323  AC6 HCT 116 C138(1.22)  LDD0640  [1]
 LDCM0324  AC60 HCT 116 C138(1.34)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C138(1.36)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C138(1.76)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C138(1.39)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C138(1.91)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C138(2.00)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C138(2.07)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C138(2.51)  LDD0648  [1]
 LDCM0334  AC7 HCT 116 C138(0.85)  LDD0651  [1]
 LDCM0345  AC8 HCT 116 C138(0.98)  LDD0662  [1]
 LDCM0248  AKOS034007472 HCT 116 C138(0.82)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C138(0.82)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C138(1.26)  LDD0592  [1]
 LDCM0367  CL1 HCT 116 C138(0.40)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C138(1.08)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C138(0.96)  LDD0686  [1]
 LDCM0370  CL101 HCT 116 C138(0.98)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C138(0.83)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C138(0.82)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C138(0.79)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C138(1.13)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C138(1.51)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C138(1.44)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C138(1.30)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C138(1.17)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C138(1.00)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C138(1.07)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C138(1.15)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C138(0.81)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C138(1.49)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C138(1.08)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C138(0.88)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C138(1.27)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C138(1.63)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C138(1.03)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C138(1.10)  LDD0706  [1]
 LDCM0390  CL12 HCT 116 C138(1.21)  LDD0707  [1]
 LDCM0391  CL120 HCT 116 C138(0.87)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C138(0.88)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C138(1.13)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C138(1.42)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C138(1.12)  LDD0712  [1]
 LDCM0396  CL125 HCT 116 C138(0.88)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C138(1.01)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C138(0.79)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C138(1.41)  LDD0716  [1]
 LDCM0400  CL13 HCT 116 C138(1.08)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C138(0.85)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C138(1.01)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C138(0.90)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C138(0.89)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C138(1.10)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C138(1.11)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C138(0.66)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C138(1.11)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C138(1.40)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C138(1.21)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C138(1.38)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C138(1.24)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C138(1.17)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C138(1.29)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C138(1.05)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C138(1.07)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C138(1.18)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C138(0.82)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C138(1.19)  LDD0736  [1]
 LDCM0429  CL4 HCT 116 C138(0.75)  LDD0746  [1]
 LDCM0436  CL46 HCT 116 C138(0.67)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C138(0.73)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C138(0.90)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C138(1.07)  LDD0756  [1]
 LDCM0440  CL5 HCT 116 C138(0.96)  LDD0757  [1]
 LDCM0441  CL50 HCT 116 C138(0.65)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C138(1.15)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C138(0.93)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C138(0.90)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C138(0.83)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C138(0.78)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C138(0.80)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C138(1.02)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C138(0.81)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C138(0.96)  LDD0767  [1]
 LDCM0451  CL6 HCT 116 C138(1.04)  LDD0768  [1]
 LDCM0452  CL60 HCT 116 C138(0.86)  LDD0769  [1]
 LDCM0453  CL61 HCT 116 C138(1.14)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C138(1.04)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C138(1.17)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C138(1.39)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C138(1.10)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C138(1.13)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C138(1.27)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C138(0.96)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C138(0.97)  LDD0778  [1]
 LDCM0462  CL7 HCT 116 C138(1.26)  LDD0779  [1]
 LDCM0463  CL70 HCT 116 C138(1.35)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C138(1.07)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C138(1.29)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C138(1.07)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C138(0.98)  LDD0784  [1]
 LDCM0469  CL76 HCT 116 C138(1.07)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C138(0.98)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C138(1.07)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C138(0.96)  LDD0789  [1]
 LDCM0473  CL8 HCT 116 C138(1.53)  LDD0790  [1]
 LDCM0474  CL80 HCT 116 C138(1.04)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C138(1.12)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C138(0.90)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C138(0.83)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C138(0.87)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C138(0.95)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C138(0.92)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C138(0.84)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C138(1.08)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C138(1.05)  LDD0800  [1]
 LDCM0484  CL9 HCT 116 C138(0.99)  LDD0801  [1]
 LDCM0485  CL90 HCT 116 C138(1.21)  LDD0802  [1]
 LDCM0486  CL91 HCT 116 C138(0.61)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C138(0.59)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C138(0.67)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C138(0.74)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C138(0.93)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C138(0.60)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C138(0.82)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C138(0.67)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C138(1.24)  LDD0811  [1]
 LDCM0468  Fragment33 HCT 116 C138(0.96)  LDD0785  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cerebellar degeneration-related protein 2 (CDR2) CDR2 family Q01850
Synaptotagmin-like protein 3 (SYTL3) . Q4VX76

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.