Details of the Target

General Information of Target

Target ID LDTP14256
Target Name Epsin-1 (EPN1)
Gene Name EPN1
Gene ID 29924
Synonyms
Epsin-1; EH domain-binding mitotic phosphoprotein; EPS-15-interacting protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGDWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPG
CENVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKEREEEEQLKRESP
SPKEPPQDNPSSRDDRGRVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFLYGFELKPLYR
CDRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHLGWKKLKQGVTSRLGP
DASEAPLGTADPPPLPPSSRPPAVAIGFPPYYAHTAAPLGQARAVGYPGAPPPAADFKLL
ALTEARGKGQSAKLYNGHHHLLMTEQNWANQAAERQPPALKAYPAASTPAAPSPVGSSSP
PLAHEAEAGAAPLLLDGSGSSLEGSALAGTPEEEEQAVTTAAQMHQPPLPLGDPGRASKA
SRASSGRARPEDLAI
Target Bioclass
Other
Family
Epsin family
Subcellular location
Cytoplasm
Function
Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations. Regulates receptor-mediated endocytosis.
Uniprot ID
Q9Y6I3
Ensemble ID
ENST00000085079.11
HGNC ID
HGNC:21604
ChEMBL ID
CHEMBL3259465

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K149(6.44); K86(8.33)  LDD0277  [1]
Probe 1
 Probe Info  		Y101(9.50)  LDD3495  [2]
DBIA
 Probe Info  		C96(2.05)  LDD3332  [3]
BTD
 Probe Info  		C96(1.32)  LDD1700  [4]
HHS-465
 Probe Info  		Y17(4.56)  LDD2237  [5]
ATP probe
 Probe Info  		N.A.  LDD0199  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [7]
NAIA_4
 Probe Info  		N.A.  LDD2226  [8]
IPM
 Probe Info  		N.A.  LDD0005  [9]
TFBX
 Probe Info  		N.A.  LDD0148  [10]
HHS-482
 Probe Info  		Y17(0.58)  LDD2239  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C96(0.75)  LDD2095  [4]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C96(0.94)  LDD2130  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C96(0.85)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C96(1.27)  LDD2152  [4]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C96(0.56)  LDD2132  [4]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C96(0.73)  LDD2131  [4]
 LDCM0215  AC10 HEK-293T C205(1.04)  LDD1508  [11]
 LDCM0237  AC12 HEK-293T C205(1.38)  LDD1510  [11]
 LDCM0259  AC14 HEK-293T C205(1.09)  LDD1512  [11]
 LDCM0270  AC15 HEK-293T C205(0.98)  LDD1513  [11]
 LDCM0277  AC18 HEK-293T C205(1.01)  LDD1516  [11]
 LDCM0279  AC2 HEK-293T C205(1.06)  LDD1518  [11]
 LDCM0280  AC20 HEK-293T C205(1.07)  LDD1519  [11]
 LDCM0281  AC21 HEK-293T C205(0.87)  LDD1520  [11]
 LDCM0282  AC22 HEK-293T C205(0.97)  LDD1521  [11]
 LDCM0283  AC23 HEK-293T C205(0.96)  LDD1522  [11]
 LDCM0284  AC24 HEK-293T C205(0.95)  LDD1523  [11]
 LDCM0286  AC26 HEK-293T C205(1.00)  LDD1525  [11]
 LDCM0288  AC28 HEK-293T C205(1.05)  LDD1527  [11]
 LDCM0289  AC29 HEK-293T C205(0.89)  LDD1528  [11]
 LDCM0291  AC30 HEK-293T C205(0.83)  LDD1530  [11]
 LDCM0292  AC31 HEK-293T C205(0.93)  LDD1531  [11]
 LDCM0293  AC32 HEK-293T C205(1.00)  LDD1532  [11]
 LDCM0295  AC34 HEK-293T C205(1.03)  LDD1534  [11]
 LDCM0297  AC36 HEK-293T C205(1.17)  LDD1536  [11]
 LDCM0298  AC37 HEK-293T C205(1.11)  LDD1537  [11]
 LDCM0299  AC38 HEK-293T C205(0.97)  LDD1538  [11]
 LDCM0300  AC39 HEK-293T C205(1.00)  LDD1539  [11]
 LDCM0301  AC4 HEK-293T C205(1.07)  LDD1540  [11]
 LDCM0302  AC40 HEK-293T C205(0.98)  LDD1541  [11]
 LDCM0304  AC42 HEK-293T C205(1.05)  LDD1543  [11]
 LDCM0306  AC44 HEK-293T C205(1.05)  LDD1545  [11]
 LDCM0307  AC45 HEK-293T C205(1.04)  LDD1546  [11]
 LDCM0308  AC46 HEK-293T C205(1.02)  LDD1547  [11]
 LDCM0309  AC47 HEK-293T C205(1.12)  LDD1548  [11]
 LDCM0310  AC48 HEK-293T C205(1.09)  LDD1549  [11]
 LDCM0312  AC5 HEK-293T C205(0.80)  LDD1551  [11]
 LDCM0313  AC50 HEK-293T C205(1.07)  LDD1552  [11]
 LDCM0315  AC52 HEK-293T C205(1.18)  LDD1554  [11]
 LDCM0316  AC53 HEK-293T C205(0.91)  LDD1555  [11]
 LDCM0317  AC54 HEK-293T C205(0.92)  LDD1556  [11]
 LDCM0318  AC55 HEK-293T C205(0.97)  LDD1557  [11]
 LDCM0319  AC56 HEK-293T C205(1.02)  LDD1558  [11]
 LDCM0321  AC58 HEK-293T C205(1.04)  LDD1560  [11]
 LDCM0323  AC6 HEK-293T C205(0.75)  LDD1562  [11]
 LDCM0324  AC60 HEK-293T C205(0.88)  LDD1563  [11]
 LDCM0325  AC61 HEK-293T C205(0.97)  LDD1564  [11]
 LDCM0326  AC62 HEK-293T C205(0.93)  LDD1565  [11]
 LDCM0327  AC63 HEK-293T C205(1.02)  LDD1566  [11]
 LDCM0328  AC64 HEK-293T C205(0.97)  LDD1567  [11]
 LDCM0334  AC7 HEK-293T C205(1.02)  LDD1568  [11]
 LDCM0345  AC8 HEK-293T C205(1.16)  LDD1569  [11]
 LDCM0545  Acetamide MDA-MB-231 C96(0.34)  LDD2138  [4]
 LDCM0520  AKOS000195272 MDA-MB-231 C96(0.83)  LDD2113  [4]
 LDCM0248  AKOS034007472 HEK-293T C205(1.00)  LDD1511  [11]
 LDCM0275  AKOS034007705 HEK-293T C205(0.97)  LDD1514  [11]
 LDCM0498  BS-3668 MDA-MB-231 C96(0.52)  LDD2091  [4]
 LDCM0367  CL1 HEK-293T C205(0.99)  LDD1571  [11]
 LDCM0368  CL10 HEK-293T C205(0.77)  LDD1572  [11]
 LDCM0369  CL100 HEK-293T C205(1.18)  LDD1573  [11]
 LDCM0370  CL101 HEK-293T C205(1.00)  LDD1574  [11]
 LDCM0372  CL103 HEK-293T C205(1.18)  LDD1576  [11]
 LDCM0373  CL104 HEK-293T C205(0.90)  LDD1577  [11]
 LDCM0374  CL105 HEK-293T C205(0.88)  LDD1578  [11]
 LDCM0376  CL107 HEK-293T C205(0.93)  LDD1580  [11]
 LDCM0377  CL108 HEK-293T C205(0.95)  LDD1581  [11]
 LDCM0378  CL109 HEK-293T C205(0.80)  LDD1582  [11]
 LDCM0379  CL11 HEK-293T C205(1.14)  LDD1583  [11]
 LDCM0381  CL111 HEK-293T C205(0.92)  LDD1585  [11]
 LDCM0382  CL112 HEK-293T C205(0.94)  LDD1586  [11]
 LDCM0383  CL113 HEK-293T C205(1.03)  LDD1587  [11]
 LDCM0385  CL115 HEK-293T C205(0.81)  LDD1589  [11]
 LDCM0386  CL116 HEK-293T C205(1.07)  LDD1590  [11]
 LDCM0387  CL117 HEK-293T C205(0.96)  LDD1591  [11]
 LDCM0389  CL119 HEK-293T C205(1.03)  LDD1593  [11]
 LDCM0390  CL12 HEK-293T C205(1.11)  LDD1594  [11]
 LDCM0391  CL120 HEK-293T C205(1.25)  LDD1595  [11]
 LDCM0392  CL121 HEK-293T C205(1.05)  LDD1596  [11]
 LDCM0394  CL123 HEK-293T C205(0.69)  LDD1598  [11]
 LDCM0395  CL124 HEK-293T C205(1.00)  LDD1599  [11]
 LDCM0396  CL125 HEK-293T C205(1.25)  LDD1600  [11]
 LDCM0398  CL127 HEK-293T C205(0.99)  LDD1602  [11]
 LDCM0399  CL128 HEK-293T C205(0.91)  LDD1603  [11]
 LDCM0400  CL13 HEK-293T C205(0.99)  LDD1604  [11]
 LDCM0402  CL15 HEK-293T C205(0.76)  LDD1606  [11]
 LDCM0403  CL16 HEK-293T C205(0.98)  LDD1607  [11]
 LDCM0405  CL18 HEK-293T C205(1.16)  LDD1609  [11]
 LDCM0408  CL20 HEK-293T C205(1.13)  LDD1612  [11]
 LDCM0409  CL21 HEK-293T C205(0.81)  LDD1613  [11]
 LDCM0410  CL22 HEK-293T C205(0.94)  LDD1614  [11]
 LDCM0411  CL23 HEK-293T C205(1.01)  LDD1615  [11]
 LDCM0412  CL24 HEK-293T C205(1.06)  LDD1616  [11]
 LDCM0413  CL25 HEK-293T C205(1.01)  LDD1617  [11]
 LDCM0415  CL27 HEK-293T C205(0.88)  LDD1619  [11]
 LDCM0416  CL28 HEK-293T C205(1.08)  LDD1620  [11]
 LDCM0418  CL3 HEK-293T C205(0.89)  LDD1622  [11]
 LDCM0419  CL30 HEK-293T C205(1.08)  LDD1623  [11]
 LDCM0421  CL32 HEK-293T C205(1.06)  LDD1625  [11]
 LDCM0422  CL33 HEK-293T C205(0.70)  LDD1626  [11]
 LDCM0423  CL34 HEK-293T C205(0.79)  LDD1627  [11]
 LDCM0424  CL35 HEK-293T C205(1.25)  LDD1628  [11]
 LDCM0425  CL36 HEK-293T C205(0.91)  LDD1629  [11]
 LDCM0426  CL37 HEK-293T C205(1.00)  LDD1630  [11]
 LDCM0428  CL39 HEK-293T C205(0.92)  LDD1632  [11]
 LDCM0429  CL4 HEK-293T C205(1.27)  LDD1633  [11]
 LDCM0430  CL40 HEK-293T C205(1.02)  LDD1634  [11]
 LDCM0432  CL42 HEK-293T C205(1.16)  LDD1636  [11]
 LDCM0434  CL44 HEK-293T C205(0.98)  LDD1638  [11]
 LDCM0435  CL45 HEK-293T C205(0.79)  LDD1639  [11]
 LDCM0436  CL46 HEK-293T C205(1.10)  LDD1640  [11]
 LDCM0437  CL47 HEK-293T C205(1.23)  LDD1641  [11]
 LDCM0438  CL48 HEK-293T C205(0.99)  LDD1642  [11]
 LDCM0439  CL49 HEK-293T C205(0.89)  LDD1643  [11]
 LDCM0443  CL52 HEK-293T C205(1.07)  LDD1646  [11]
 LDCM0445  CL54 HEK-293T C205(1.10)  LDD1648  [11]
 LDCM0447  CL56 HEK-293T C205(0.93)  LDD1650  [11]
 LDCM0448  CL57 HEK-293T C205(0.91)  LDD1651  [11]
 LDCM0449  CL58 HEK-293T C205(0.93)  LDD1652  [11]
 LDCM0450  CL59 HEK-293T C205(1.00)  LDD1653  [11]
 LDCM0451  CL6 HEK-293T C205(1.06)  LDD1654  [11]
 LDCM0452  CL60 HEK-293T C205(1.16)  LDD1655  [11]
 LDCM0453  CL61 HEK-293T C205(1.09)  LDD1656  [11]
 LDCM0455  CL63 HEK-293T C205(0.98)  LDD1658  [11]
 LDCM0456  CL64 HEK-293T C205(1.14)  LDD1659  [11]
 LDCM0458  CL66 HEK-293T C205(1.12)  LDD1661  [11]
 LDCM0460  CL68 HEK-293T C205(0.91)  LDD1663  [11]
 LDCM0461  CL69 HEK-293T C205(0.82)  LDD1664  [11]
 LDCM0463  CL70 HEK-293T C205(0.99)  LDD1666  [11]
 LDCM0464  CL71 HEK-293T C205(1.16)  LDD1667  [11]
 LDCM0465  CL72 HEK-293T C205(1.16)  LDD1668  [11]
 LDCM0466  CL73 HEK-293T C205(1.25)  LDD1669  [11]
 LDCM0469  CL76 HEK-293T C205(1.01)  LDD1672  [11]
 LDCM0471  CL78 HEK-293T C205(1.13)  LDD1674  [11]
 LDCM0473  CL8 HEK-293T C205(0.90)  LDD1676  [11]
 LDCM0474  CL80 HEK-293T C205(0.93)  LDD1677  [11]
 LDCM0475  CL81 HEK-293T C205(0.88)  LDD1678  [11]
 LDCM0476  CL82 HEK-293T C205(0.99)  LDD1679  [11]
 LDCM0477  CL83 HEK-293T C205(1.26)  LDD1680  [11]
 LDCM0478  CL84 HEK-293T C205(0.80)  LDD1681  [11]
 LDCM0479  CL85 HEK-293T C205(1.04)  LDD1682  [11]
 LDCM0481  CL87 HEK-293T C205(0.88)  LDD1684  [11]
 LDCM0482  CL88 HEK-293T C205(0.95)  LDD1685  [11]
 LDCM0484  CL9 HEK-293T C205(0.95)  LDD1687  [11]
 LDCM0485  CL90 HEK-293T C205(1.08)  LDD1688  [11]
 LDCM0487  CL92 HEK-293T C205(0.87)  LDD1690  [11]
 LDCM0488  CL93 HEK-293T C205(0.70)  LDD1691  [11]
 LDCM0489  CL94 HEK-293T C205(0.93)  LDD1692  [11]
 LDCM0490  CL95 HEK-293T C205(1.16)  LDD1693  [11]
 LDCM0491  CL96 HEK-293T C205(0.88)  LDD1694  [11]
 LDCM0492  CL97 HEK-293T C205(0.81)  LDD1695  [11]
 LDCM0494  CL99 HEK-293T C205(1.12)  LDD1697  [11]
 LDCM0495  E2913 HEK-293T C205(0.89)  LDD1698  [11]
 LDCM0625  F8 Ramos C96(1.21)  LDD2187  [12]
 LDCM0572  Fragment10 Ramos C96(0.80)  LDD2189  [12]
 LDCM0573  Fragment11 Ramos C96(3.82)  LDD2190  [12]
 LDCM0574  Fragment12 Ramos C96(0.82)  LDD2191  [12]
 LDCM0575  Fragment13 Ramos C96(0.88)  LDD2192  [12]
 LDCM0579  Fragment20 Ramos C96(0.54)  LDD2194  [12]
 LDCM0580  Fragment21 Ramos C96(0.79)  LDD2195  [12]
 LDCM0582  Fragment23 Ramos C96(1.07)  LDD2196  [12]
 LDCM0578  Fragment27 Ramos C96(0.86)  LDD2197  [12]
 LDCM0586  Fragment28 Ramos C96(0.99)  LDD2198  [12]
 LDCM0588  Fragment30 Ramos C96(1.32)  LDD2199  [12]
 LDCM0589  Fragment31 Ramos C96(1.18)  LDD2200  [12]
 LDCM0590  Fragment32 Ramos C96(0.77)  LDD2201  [12]
 LDCM0468  Fragment33 HEK-293T C205(0.93)  LDD1671  [11]
 LDCM0596  Fragment38 Ramos C96(0.84)  LDD2203  [12]
 LDCM0610  Fragment52 Ramos C96(1.19)  LDD2204  [12]
 LDCM0614  Fragment56 Ramos C96(1.24)  LDD2205  [12]
 LDCM0569  Fragment7 Ramos C96(0.50)  LDD2186  [12]
 LDCM0571  Fragment9 Ramos C96(0.78)  LDD2188  [12]
 LDCM0022  KB02 HEK-293T C205(0.89)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C205(0.88)  LDD1497  [11]
 LDCM0024  KB05 MKN45 C96(2.05)  LDD3332  [3]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C96(0.38)  LDD2121  [4]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C96(0.49)  LDD2089  [4]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C96(1.51)  LDD2090  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C96(1.16)  LDD2093  [4]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C96(0.23)  LDD2096  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C96(0.93)  LDD2099  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C96(0.99)  LDD2107  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C96(1.06)  LDD2111  [4]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C96(0.57)  LDD2115  [4]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C96(0.42)  LDD2118  [4]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C96(1.03)  LDD2120  [4]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C96(0.35)  LDD2124  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C96(0.78)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C96(1.02)  LDD2127  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C96(1.25)  LDD2128  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C96(1.13)  LDD2129  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C96(0.50)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C96(1.03)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C96(1.21)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C96(1.07)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C96(1.32)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C96(0.70)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C96(0.19)  LDD2141  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C96(1.31)  LDD2143  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C96(3.66)  LDD2144  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C96(0.78)  LDD2146  [4]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C96(4.34)  LDD2147  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C96(0.51)  LDD2148  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C96(0.37)  LDD2150  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF) CDIP1/LITAF family Q99732
Endosomal transmembrane epsin interactor 1 (ENTREP1) ENTREP family Q15884
DAZ-associated protein 2 (DAZAP2) . Q15038
Epidermal growth factor receptor substrate 15 (EPS15) . P42566
Pleckstrin homology domain-containing family B member 2 (PLEKHB2) . Q96CS7

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
14-dioxane Small molecular drug DB03316
1d-myo-inositol 145-trisphosphate Small molecular drug DB03401

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578