Details of the Target

General Information of Target

Target ID LDTP14147
Target Name General transcription factor 3C polypeptide 5 (GTF3C5)
Gene Name GTF3C5
Gene ID 9328
Synonyms
General transcription factor 3C polypeptide 5; TF3C-epsilon; Transcription factor IIIC 63 kDa subunit; TFIIIC 63 kDa subunit; TFIIIC63; Transcription factor IIIC subunit epsilon
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKGSIFTLFLFSVLFAISEVRSKESVRLCGLEYIRTVIYICASSRWRRHQEGIPQAQQAE
TGNSFQLPHKREFSEENPAQNLPKVDASGEDRLWGGQMPTEELWKSKKHSVMSRQDLQTL
CCTDGCSMTDLSALC
Target Bioclass
Other
Family
TFIIIC subunit 5 family
Subcellular location
Nucleus
Function Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.
Uniprot ID
Q9Y5Q8
Ensemble ID
ENST00000372097.10
HGNC ID
HGNC:4668

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 Deletion: p.A12PfsTer7 DBIA    Probe Info 
JURKAT SNV: p.N220K Compound 10    Probe Info 
MCC13 SNV: p.R185Q DBIA    Probe Info 
MEWO SNV: p.E157K; p.P503L DBIA    Probe Info 
OVK18 SNV: p.K387R DBIA    Probe Info 
PC9 SNV: p.Q409K .
RPMI8226 SNV: p.F467S DBIA    Probe Info 
TFK1 SNV: p.D128N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y182(20.00); Y347(20.00); Y184(5.28)  LDD0257  [2]
BTD
 Probe Info  		C242(0.30)  LDD2089  [3]
DBIA
 Probe Info  		C242(8.53); C242(128.52)  LDD0209  [4]
HHS-475
 Probe Info  		Y194(0.62); Y331(1.17)  LDD0264  [5]
HHS-465
 Probe Info  		Y184(5.33); Y194(5.08)  LDD2237  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C439(0.00); C26(0.00); C432(0.00); C411(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C439(0.00); C26(0.00); C432(0.00); C411(0.00)  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		C439(0.00); C411(0.00); C242(0.00); C26(0.00)  LDD0037  [7]
TFBX
 Probe Info  		C242(0.00); C325(0.00)  LDD0027  [8]
Compound 10
 Probe Info  		N.A.  LDD2216  [9]
IPM
 Probe Info  		C242(0.00); C325(0.00)  LDD0147  [8]
SF
 Probe Info  		N.A.  LDD0028  [10]
1d-yne
 Probe Info  		N.A.  LDD0357  [11]
Acrolein
 Probe Info  		C432(0.00); C26(0.00)  LDD0217  [12]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [12]
Methacrolein
 Probe Info  		C432(0.00); C26(0.00)  LDD0218  [12]
W1
 Probe Info  		N.A.  LDD0236  [13]
AOyne
 Probe Info  		15.00  LDD0443  [14]
NAIA_5
 Probe Info  		C432(0.00); C26(0.00); C242(0.00)  LDD2223  [15]
HHS-482
 Probe Info  		Y194(0.73); Y331(0.84)  LDD2239  [6]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C242(0.74)  LDD2117  [3]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C242(1.26)  LDD2152  [3]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C242(0.93)  LDD2103  [3]
 LDCM0214  AC1 HEK-293T C242(1.05); C26(0.97); C432(1.49); C411(1.09)  LDD1507  [17]
 LDCM0215  AC10 HEK-293T C242(0.99); C26(0.93); C411(1.00); C75(0.95)  LDD1508  [17]
 LDCM0226  AC11 HEK-293T C242(1.05); C26(1.08); C432(1.41); C411(1.13)  LDD1509  [17]
 LDCM0237  AC12 HEK-293T C242(0.98); C439(0.97); C26(0.97); C432(1.21)  LDD1510  [17]
 LDCM0259  AC14 HEK-293T C242(1.09); C439(1.07); C26(1.05); C432(1.07)  LDD1512  [17]
 LDCM0270  AC15 HEK-293T C242(1.05); C26(0.98); C432(1.38); C411(1.09)  LDD1513  [17]
 LDCM0276  AC17 HEK-293T C242(1.02); C26(0.92); C432(1.17); C411(0.93)  LDD1515  [17]
 LDCM0277  AC18 HEK-293T C242(1.04); C26(0.94); C411(1.10); C75(1.04)  LDD1516  [17]
 LDCM0278  AC19 HEK-293T C242(0.99); C26(0.87); C432(1.40); C411(1.02)  LDD1517  [17]
 LDCM0279  AC2 HEK-293T C242(1.08); C26(1.00); C411(1.19); C75(0.93)  LDD1518  [17]
 LDCM0280  AC20 HEK-293T C242(1.00); C439(1.06); C26(0.95); C432(1.26)  LDD1519  [17]
 LDCM0281  AC21 HEK-293T C242(1.01); C439(0.94); C26(1.02); C432(0.72)  LDD1520  [17]
 LDCM0282  AC22 HEK-293T C242(1.00); C439(1.04); C26(1.06); C432(0.99)  LDD1521  [17]
 LDCM0283  AC23 HEK-293T C242(1.04); C26(0.99); C432(1.08); C411(1.08)  LDD1522  [17]
 LDCM0284  AC24 HEK-293T C242(1.13); C439(1.09); C411(0.93); C75(0.91)  LDD1523  [17]
 LDCM0285  AC25 HEK-293T C242(0.97); C26(1.01); C432(1.58); C411(0.87)  LDD1524  [17]
 LDCM0286  AC26 HEK-293T C242(1.01); C26(0.96); C411(0.96); C75(0.95)  LDD1525  [17]
 LDCM0287  AC27 HEK-293T C242(1.02); C26(1.04); C432(1.08); C411(0.98)  LDD1526  [17]
 LDCM0288  AC28 HEK-293T C242(0.92); C439(1.12); C26(0.99); C432(1.11)  LDD1527  [17]
 LDCM0289  AC29 HEK-293T C242(1.02); C439(0.89); C26(1.01); C432(1.01)  LDD1528  [17]
 LDCM0290  AC3 HEK-293T C242(0.99); C26(1.05); C432(1.08); C411(1.07)  LDD1529  [17]
 LDCM0291  AC30 HEK-293T C242(0.99); C439(0.96); C26(0.99); C432(1.14)  LDD1530  [17]
 LDCM0292  AC31 HEK-293T C242(1.07); C26(0.99); C432(1.43); C411(0.99)  LDD1531  [17]
 LDCM0293  AC32 HEK-293T C242(1.04); C439(1.06); C411(1.01); C75(1.00)  LDD1532  [17]
 LDCM0294  AC33 HEK-293T C242(1.02); C26(0.98); C432(1.23); C411(0.95)  LDD1533  [17]
 LDCM0295  AC34 HEK-293T C242(1.01); C26(0.96); C411(1.21); C75(0.92)  LDD1534  [17]
 LDCM0296  AC35 HEK-293T C242(0.98); C26(1.08); C432(0.94); C411(0.99)  LDD1535  [17]
 LDCM0297  AC36 HEK-293T C242(0.92); C439(1.04); C26(0.98); C432(1.44)  LDD1536  [17]
 LDCM0298  AC37 HEK-293T C242(1.04); C439(0.99); C26(1.13); C432(1.06)  LDD1537  [17]
 LDCM0299  AC38 HEK-293T C242(0.99); C439(1.03); C26(1.07); C432(0.94)  LDD1538  [17]
 LDCM0300  AC39 HEK-293T C242(1.05); C26(1.03); C432(1.10); C411(1.12)  LDD1539  [17]
 LDCM0301  AC4 HEK-293T C242(0.94); C439(0.99); C26(0.95); C432(0.97)  LDD1540  [17]
 LDCM0302  AC40 HEK-293T C242(1.01); C439(1.14); C411(0.91); C75(1.19)  LDD1541  [17]
 LDCM0303  AC41 HEK-293T C242(1.02); C26(1.03); C432(1.43); C411(1.09)  LDD1542  [17]
 LDCM0304  AC42 HEK-293T C242(1.01); C26(0.93); C411(1.23); C75(0.92)  LDD1543  [17]
 LDCM0305  AC43 HEK-293T C242(1.02); C26(1.02); C432(1.11); C411(1.01)  LDD1544  [17]
 LDCM0306  AC44 HEK-293T C242(0.99); C439(1.11); C26(1.04); C432(1.03)  LDD1545  [17]
 LDCM0307  AC45 HEK-293T C242(1.02); C439(1.08); C26(1.06); C432(1.08)  LDD1546  [17]
 LDCM0308  AC46 HEK-293T C242(1.05); C439(1.04); C26(1.18); C432(1.06)  LDD1547  [17]
 LDCM0309  AC47 HEK-293T C242(1.04); C26(1.11); C432(1.15); C411(1.12)  LDD1548  [17]
 LDCM0310  AC48 HEK-293T C242(1.04); C439(1.11); C411(1.03); C75(0.98)  LDD1549  [17]
 LDCM0311  AC49 HEK-293T C242(1.00); C26(1.06); C432(1.18); C411(1.00)  LDD1550  [17]
 LDCM0312  AC5 HEK-293T C242(1.00); C439(0.92); C26(1.13); C432(1.03)  LDD1551  [17]
 LDCM0313  AC50 HEK-293T C242(1.01); C26(1.10); C411(1.11); C75(0.87)  LDD1552  [17]
 LDCM0314  AC51 HEK-293T C242(1.05); C26(1.09); C432(1.34); C411(1.08)  LDD1553  [17]
 LDCM0315  AC52 HEK-293T C242(0.97); C439(1.05); C26(1.02); C432(1.34)  LDD1554  [17]
 LDCM0316  AC53 HEK-293T C242(1.07); C439(1.02); C26(0.94); C432(1.09)  LDD1555  [17]
 LDCM0317  AC54 HEK-293T C242(1.03); C439(1.08); C26(1.01); C432(1.08)  LDD1556  [17]
 LDCM0318  AC55 HEK-293T C242(1.09); C26(1.03); C432(1.16); C411(1.07)  LDD1557  [17]
 LDCM0319  AC56 HEK-293T C242(1.04); C439(1.13); C411(1.06); C75(0.98)  LDD1558  [17]
 LDCM0320  AC57 HEK-293T C242(0.98); C26(0.98); C432(1.16); C411(1.03)  LDD1559  [17]
 LDCM0321  AC58 HEK-293T C242(1.02); C26(0.99); C411(1.33); C75(0.88)  LDD1560  [17]
 LDCM0322  AC59 HEK-293T C242(1.01); C26(0.98); C432(1.11); C411(1.00)  LDD1561  [17]
 LDCM0323  AC6 HEK-293T C242(1.08); C439(1.02); C26(1.03); C432(0.98)  LDD1562  [17]
 LDCM0324  AC60 HEK-293T C242(0.97); C439(1.07); C26(1.02); C432(1.12)  LDD1563  [17]
 LDCM0325  AC61 HEK-293T C242(0.99); C439(1.01); C26(1.01); C432(1.04)  LDD1564  [17]
 LDCM0326  AC62 HEK-293T C242(1.05); C439(1.00); C26(1.05); C432(0.99)  LDD1565  [17]
 LDCM0327  AC63 HEK-293T C242(1.02); C26(1.09); C432(0.98); C411(1.02)  LDD1566  [17]
 LDCM0328  AC64 HEK-293T C242(1.00); C439(1.08); C411(1.12); C75(0.96)  LDD1567  [17]
 LDCM0334  AC7 HEK-293T C242(1.10); C26(1.00); C432(1.06); C411(1.10)  LDD1568  [17]
 LDCM0345  AC8 HEK-293T C242(0.97); C439(1.06); C411(0.97); C75(0.99)  LDD1569  [17]
 LDCM0248  AKOS034007472 HEK-293T C242(1.02); C439(0.98); C26(1.06); C432(1.02)  LDD1511  [17]
 LDCM0356  AKOS034007680 HEK-293T C242(1.01); C26(1.00); C432(1.37); C411(1.03)  LDD1570  [17]
 LDCM0275  AKOS034007705 HEK-293T C242(1.02); C439(1.08); C411(1.12); C75(1.05)  LDD1514  [17]
 LDCM0156  Aniline NCI-H1299 11.87  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C242(0.49)  LDD2091  [3]
 LDCM0108  Chloroacetamide HeLa C26(0.00); C242(0.00); C432(0.00); H329(0.00)  LDD0222  [12]
 LDCM0632  CL-Sc Hep-G2 C432(1.98)  LDD2227  [15]
 LDCM0367  CL1 HEK-293T C242(0.92); C439(1.12); C26(1.14); C432(0.96)  LDD1571  [17]
 LDCM0368  CL10 HEK-293T C242(0.97); C439(0.92); C26(0.76); C432(0.86)  LDD1572  [17]
 LDCM0369  CL100 HEK-293T C242(1.02); C26(0.93); C432(0.88); C411(1.02)  LDD1573  [17]
 LDCM0370  CL101 HEK-293T C242(0.97); C439(1.04); C26(0.94); C432(1.31)  LDD1574  [17]
 LDCM0371  CL102 HEK-293T C242(1.02); C26(0.96); C411(1.14); C75(0.89)  LDD1575  [17]
 LDCM0372  CL103 HEK-293T C242(0.98); C26(1.02); C432(1.02); C75(0.97)  LDD1576  [17]
 LDCM0373  CL104 HEK-293T C242(1.09); C26(1.09); C432(1.13); C411(1.10)  LDD1577  [17]
 LDCM0374  CL105 HEK-293T C242(1.01); C439(1.06); C26(1.03); C432(1.11)  LDD1578  [17]
 LDCM0375  CL106 HEK-293T C242(1.03); C26(0.91); C411(1.03); C75(0.96)  LDD1579  [17]
 LDCM0376  CL107 HEK-293T C242(1.00); C26(1.03); C432(1.14); C75(0.90)  LDD1580  [17]
 LDCM0377  CL108 HEK-293T C242(1.03); C26(1.00); C432(1.62); C411(1.08)  LDD1581  [17]
 LDCM0378  CL109 HEK-293T C242(0.96); C439(1.11); C26(0.91); C432(0.93)  LDD1582  [17]
 LDCM0379  CL11 HEK-293T C242(1.07); C26(0.97); C432(0.91); C411(0.97)  LDD1583  [17]
 LDCM0380  CL110 HEK-293T C242(0.97); C26(0.97); C411(0.85); C75(0.92)  LDD1584  [17]
 LDCM0381  CL111 HEK-293T C242(1.01); C26(0.93); C432(0.92); C75(0.89)  LDD1585  [17]
 LDCM0382  CL112 HEK-293T C242(1.01); C26(0.97); C432(1.11); C411(0.96)  LDD1586  [17]
 LDCM0383  CL113 HEK-293T C242(0.95); C439(1.08); C26(0.98); C432(1.11)  LDD1587  [17]
 LDCM0384  CL114 HEK-293T C242(0.98); C26(0.93); C411(0.91); C75(0.89)  LDD1588  [17]
 LDCM0385  CL115 HEK-293T C242(1.02); C26(1.00); C432(1.05); C75(0.93)  LDD1589  [17]
 LDCM0386  CL116 HEK-293T C242(1.05); C26(1.00); C432(1.21); C411(1.05)  LDD1590  [17]
 LDCM0387  CL117 HEK-293T C242(0.93); C439(1.04); C26(0.98); C432(1.18)  LDD1591  [17]
 LDCM0388  CL118 HEK-293T C242(1.05); C26(1.05); C411(1.07); C75(0.93)  LDD1592  [17]
 LDCM0389  CL119 HEK-293T C242(1.03); C26(1.01); C432(1.11); C75(0.97)  LDD1593  [17]
 LDCM0390  CL12 HEK-293T C242(1.07); C439(1.05); C411(0.80); C75(1.11)  LDD1594  [17]
 LDCM0391  CL120 HEK-293T C242(1.09); C26(1.10); C432(1.35); C411(0.95)  LDD1595  [17]
 LDCM0392  CL121 HEK-293T C242(0.96); C439(0.99); C26(1.00); C432(1.17)  LDD1596  [17]
 LDCM0393  CL122 HEK-293T C242(1.04); C26(1.01); C411(1.21); C75(1.02)  LDD1597  [17]
 LDCM0394  CL123 HEK-293T C242(0.98); C26(0.81); C432(1.16); C75(0.94)  LDD1598  [17]
 LDCM0395  CL124 HEK-293T C242(0.97); C26(0.99); C432(0.90); C411(0.94)  LDD1599  [17]
 LDCM0396  CL125 HEK-293T C242(0.94); C439(1.05); C26(0.88); C432(1.15)  LDD1600  [17]
 LDCM0397  CL126 HEK-293T C242(1.00); C26(1.02); C411(1.13); C75(1.02)  LDD1601  [17]
 LDCM0398  CL127 HEK-293T C242(1.00); C26(1.06); C432(1.18); C75(1.06)  LDD1602  [17]
 LDCM0399  CL128 HEK-293T C242(1.02); C26(0.96); C432(1.23); C411(1.14)  LDD1603  [17]
 LDCM0400  CL13 HEK-293T C242(0.90); C439(0.97); C26(1.07); C432(1.04)  LDD1604  [17]
 LDCM0401  CL14 HEK-293T C242(1.02); C26(1.04); C411(0.52); C75(0.96)  LDD1605  [17]
 LDCM0402  CL15 HEK-293T C242(0.98); C26(0.88); C432(1.25); C75(0.90)  LDD1606  [17]
 LDCM0403  CL16 HEK-293T C242(1.01); C26(1.10); C432(1.26); C411(1.06)  LDD1607  [17]
 LDCM0404  CL17 HEK-293T C242(0.93); C26(0.91); C432(1.34); C411(0.95)  LDD1608  [17]
 LDCM0405  CL18 HEK-293T C242(1.00); C26(0.96); C411(1.15); C75(0.99)  LDD1609  [17]
 LDCM0406  CL19 HEK-293T C242(0.96); C26(1.00); C432(1.25); C411(1.04)  LDD1610  [17]
 LDCM0407  CL2 HEK-293T C242(1.02); C26(1.08); C411(1.22); C75(0.92)  LDD1611  [17]
 LDCM0408  CL20 HEK-293T C242(0.97); C439(1.13); C26(1.12); C432(0.89)  LDD1612  [17]
 LDCM0409  CL21 HEK-293T C242(1.03); C439(0.94); C26(1.02); C432(1.30)  LDD1613  [17]
 LDCM0410  CL22 HEK-293T C242(0.96); C439(1.00); C26(0.97); C432(0.97)  LDD1614  [17]
 LDCM0411  CL23 HEK-293T C242(1.11); C26(1.03); C432(1.24); C411(0.96)  LDD1615  [17]
 LDCM0412  CL24 HEK-293T C242(1.07); C439(1.12); C411(0.82); C75(1.13)  LDD1616  [17]
 LDCM0413  CL25 HEK-293T C242(0.94); C439(1.06); C26(0.84); C432(1.03)  LDD1617  [17]
 LDCM0414  CL26 HEK-293T C242(1.06); C26(1.06); C411(1.05); C75(1.08)  LDD1618  [17]
 LDCM0415  CL27 HEK-293T C242(1.06); C26(1.05); C432(1.22); C75(1.04)  LDD1619  [17]
 LDCM0416  CL28 HEK-293T C242(1.03); C26(0.94); C432(1.34); C411(1.00)  LDD1620  [17]
 LDCM0417  CL29 HEK-293T C242(1.03); C26(1.08); C432(1.59); C411(1.06)  LDD1621  [17]
 LDCM0418  CL3 HEK-293T C242(1.01); C26(1.00); C432(0.97); C75(1.03)  LDD1622  [17]
 LDCM0419  CL30 HEK-293T C242(1.03); C26(1.13); C411(1.15); C75(1.11)  LDD1623  [17]
 LDCM0420  CL31 HEK-293T C242(0.95); C26(1.04); C432(1.01); C411(0.96)  LDD1624  [17]
 LDCM0421  CL32 HEK-293T C242(0.99); C439(0.97); C26(1.04); C432(1.00)  LDD1625  [17]
 LDCM0422  CL33 HEK-293T C242(1.04); C439(0.99); C26(0.89); C432(1.06)  LDD1626  [17]
 LDCM0423  CL34 HEK-293T C242(0.99); C439(0.98); C26(0.92); C432(1.08)  LDD1627  [17]
 LDCM0424  CL35 HEK-293T C242(1.16); C26(0.98); C432(1.07); C411(0.90)  LDD1628  [17]
 LDCM0425  CL36 HEK-293T C242(1.12); C439(1.00); C411(0.82); C75(1.10)  LDD1629  [17]
 LDCM0426  CL37 HEK-293T C242(0.94); C439(1.13); C26(1.04); C432(0.84)  LDD1630  [17]
 LDCM0428  CL39 HEK-293T C242(1.04); C26(0.93); C432(1.07); C75(1.07)  LDD1632  [17]
 LDCM0429  CL4 HEK-293T C242(1.00); C26(1.03); C432(0.85); C411(1.03)  LDD1633  [17]
 LDCM0430  CL40 HEK-293T C242(1.08); C26(1.24); C432(1.25); C411(1.13)  LDD1634  [17]
 LDCM0431  CL41 HEK-293T C242(0.98); C26(0.97); C432(1.48); C411(1.17)  LDD1635  [17]
 LDCM0432  CL42 HEK-293T C242(1.06); C26(1.04); C411(1.11); C75(0.87)  LDD1636  [17]
 LDCM0433  CL43 HEK-293T C242(1.01); C26(1.07); C432(0.92); C411(1.09)  LDD1637  [17]
 LDCM0434  CL44 HEK-293T C242(0.97); C439(1.01); C26(1.07); C432(0.74)  LDD1638  [17]
 LDCM0435  CL45 HEK-293T C242(1.04); C439(0.98); C26(0.93); C432(1.01)  LDD1639  [17]
 LDCM0436  CL46 HEK-293T C242(0.98); C439(0.94); C26(0.91); C432(1.06)  LDD1640  [17]
 LDCM0437  CL47 HEK-293T C242(1.17); C26(0.89); C432(1.18); C411(0.89)  LDD1641  [17]
 LDCM0438  CL48 HEK-293T C242(1.09); C439(1.03); C411(0.82); C75(1.12)  LDD1642  [17]
 LDCM0439  CL49 HEK-293T C242(0.99); C439(1.09); C26(1.16); C432(1.23)  LDD1643  [17]
 LDCM0440  CL5 HEK-293T C242(0.95); C26(1.01); C432(1.13); C411(1.10)  LDD1644  [17]
 LDCM0441  CL50 HEK-293T C242(1.00); C26(1.16); C411(1.13); C75(1.00)  LDD1645  [17]
 LDCM0443  CL52 HEK-293T C242(1.03); C26(1.21); C432(0.89); C411(1.07)  LDD1646  [17]
 LDCM0444  CL53 HEK-293T C242(0.96); C26(0.96); C432(1.24); C411(1.28)  LDD1647  [17]
 LDCM0445  CL54 HEK-293T C242(0.96); C26(0.90); C411(1.02); C75(0.95)  LDD1648  [17]
 LDCM0446  CL55 HEK-293T C242(1.02); C26(1.18); C432(1.17); C411(1.13)  LDD1649  [17]
 LDCM0447  CL56 HEK-293T C242(0.98); C439(0.97); C26(0.89); C432(1.33)  LDD1650  [17]
 LDCM0448  CL57 HEK-293T C242(1.03); C439(0.95); C26(1.24); C432(1.10)  LDD1651  [17]
 LDCM0449  CL58 HEK-293T C242(1.03); C439(1.03); C26(1.18); C432(0.88)  LDD1652  [17]
 LDCM0450  CL59 HEK-293T C242(1.17); C26(1.05); C432(1.26); C411(1.00)  LDD1653  [17]
 LDCM0451  CL6 HEK-293T C242(1.00); C26(0.99); C411(0.95); C75(1.01)  LDD1654  [17]
 LDCM0452  CL60 HEK-293T C242(1.02); C439(1.09); C411(0.91); C75(1.21)  LDD1655  [17]
 LDCM0453  CL61 HEK-293T C242(0.87); C439(1.09); C26(1.07); C432(1.08)  LDD1656  [17]
 LDCM0454  CL62 HEK-293T C242(1.10); C26(1.07); C411(0.91); C75(1.03)  LDD1657  [17]
 LDCM0455  CL63 HEK-293T C242(1.04); C26(1.01); C432(0.95); C75(0.96)  LDD1658  [17]
 LDCM0456  CL64 HEK-293T C242(1.02); C26(0.86); C432(1.16); C411(1.04)  LDD1659  [17]
 LDCM0457  CL65 HEK-293T C242(1.00); C26(1.02); C432(1.16); C411(1.10)  LDD1660  [17]
 LDCM0458  CL66 HEK-293T C242(1.01); C26(1.05); C411(1.25); C75(0.93)  LDD1661  [17]
 LDCM0459  CL67 HEK-293T C242(1.03); C26(1.06); C432(1.06); C411(1.08)  LDD1662  [17]
 LDCM0460  CL68 HEK-293T C242(1.00); C439(1.03); C26(1.01); C432(1.03)  LDD1663  [17]
 LDCM0461  CL69 HEK-293T C242(1.06); C439(1.03); C26(1.01); C432(1.23)  LDD1664  [17]
 LDCM0462  CL7 HEK-293T C242(0.98); C26(0.94); C432(1.23); C411(1.12)  LDD1665  [17]
 LDCM0463  CL70 HEK-293T C242(0.99); C439(1.09); C26(1.01); C432(1.12)  LDD1666  [17]
 LDCM0464  CL71 HEK-293T C242(1.23); C26(1.06); C432(1.37); C411(0.95)  LDD1667  [17]
 LDCM0465  CL72 HEK-293T C242(1.15); C439(1.04); C411(0.87); C75(1.13)  LDD1668  [17]
 LDCM0466  CL73 HEK-293T C242(0.91); C439(0.98); C26(0.96); C432(1.02)  LDD1669  [17]
 LDCM0467  CL74 HEK-293T C242(1.04); C26(1.07); C411(1.18); C75(0.89)  LDD1670  [17]
 LDCM0469  CL76 HEK-293T C242(1.04); C26(1.03); C432(1.00); C411(1.10)  LDD1672  [17]
 LDCM0470  CL77 HEK-293T C242(0.98); C26(0.95); C432(0.93); C411(0.96)  LDD1673  [17]
 LDCM0471  CL78 HEK-293T C242(1.06); C26(1.01); C411(1.17); C75(1.04)  LDD1674  [17]
 LDCM0472  CL79 HEK-293T C242(1.01); C26(0.88); C432(1.28); C411(1.00)  LDD1675  [17]
 LDCM0473  CL8 HEK-293T C242(0.90); C439(0.92); C26(0.80); C432(0.75)  LDD1676  [17]
 LDCM0474  CL80 HEK-293T C242(1.03); C439(1.17); C26(1.23); C432(0.92)  LDD1677  [17]
 LDCM0475  CL81 HEK-293T C242(1.03); C439(1.00); C26(1.13); C432(1.08)  LDD1678  [17]
 LDCM0476  CL82 HEK-293T C242(0.95); C439(1.09); C26(1.04); C432(0.93)  LDD1679  [17]
 LDCM0477  CL83 HEK-293T C242(1.13); C26(0.97); C432(1.43); C411(0.97)  LDD1680  [17]
 LDCM0478  CL84 HEK-293T C242(1.08); C439(0.99); C411(0.83); C75(1.06)  LDD1681  [17]
 LDCM0479  CL85 HEK-293T C242(0.86); C439(1.11); C26(0.98); C432(1.03)  LDD1682  [17]
 LDCM0480  CL86 HEK-293T C242(1.13); C26(1.04); C411(1.21); C75(1.02)  LDD1683  [17]
 LDCM0481  CL87 HEK-293T C242(1.06); C26(1.00); C432(1.12); C75(1.02)  LDD1684  [17]
 LDCM0482  CL88 HEK-293T C242(1.03); C26(1.14); C432(1.12); C411(1.19)  LDD1685  [17]
 LDCM0483  CL89 HEK-293T C242(1.06); C26(1.00); C432(1.93); C411(1.22)  LDD1686  [17]
 LDCM0484  CL9 HEK-293T C242(1.01); C439(0.93); C26(1.17); C432(0.73)  LDD1687  [17]
 LDCM0485  CL90 HEK-293T C242(1.01); C26(0.76); C411(1.14); C75(0.82)  LDD1688  [17]
 LDCM0486  CL91 HEK-293T C242(1.02); C26(1.14); C432(1.38); C411(1.25)  LDD1689  [17]
 LDCM0487  CL92 HEK-293T C242(0.93); C439(1.17); C26(1.11); C432(0.95)  LDD1690  [17]
 LDCM0488  CL93 HEK-293T C242(1.03); C439(0.95); C26(0.99); C432(1.04)  LDD1691  [17]
 LDCM0489  CL94 HEK-293T C242(1.06); C439(0.94); C26(0.99); C432(1.03)  LDD1692  [17]
 LDCM0490  CL95 HEK-293T C242(1.12); C26(0.81); C432(1.14); C411(0.82)  LDD1693  [17]
 LDCM0491  CL96 HEK-293T C242(1.01); C439(1.02); C411(0.93); C75(1.05)  LDD1694  [17]
 LDCM0492  CL97 HEK-293T C242(0.95); C439(1.01); C26(0.99); C432(1.71)  LDD1695  [17]
 LDCM0493  CL98 HEK-293T C242(0.98); C26(0.94); C411(0.87); C75(0.89)  LDD1696  [17]
 LDCM0494  CL99 HEK-293T C242(1.03); C26(0.93); C432(1.04); C75(0.99)  LDD1697  [17]
 LDCM0495  E2913 HEK-293T C242(1.02); C26(1.20); C432(1.14); C75(1.03)  LDD1698  [17]
 LDCM0468  Fragment33 HEK-293T C242(1.02); C26(1.03); C432(1.09); C75(0.97)  LDD1671  [17]
 LDCM0427  Fragment51 HEK-293T C242(1.07); C26(1.09); C411(1.12); C75(0.92)  LDD1631  [17]
 LDCM0116  HHS-0101 DM93 Y194(0.62); Y331(1.17)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y331(0.89); Y194(1.83)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y331(1.60); Y194(1.62)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y331(1.24)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y331(0.96); Y194(2.12)  LDD0268  [5]
 LDCM0107  IAA HeLa N.A.  LDD0221  [12]
 LDCM0022  KB02 HEK-293T C432(1.11); C242(0.88); C26(0.96); C75(1.06)  LDD1492  [17]
 LDCM0023  KB03 Jurkat C242(8.53); C242(128.52)  LDD0209  [4]
 LDCM0024  KB05 Hs 936.T C439(1.68)  LDD3313  [18]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C242(0.90)  LDD2102  [3]
 LDCM0109  NEM HeLa N.A.  LDD0223  [12]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C242(0.30)  LDD2089  [3]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C242(0.98)  LDD2090  [3]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C242(0.86)  LDD2092  [3]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C242(0.86)  LDD2093  [3]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C242(1.10)  LDD2094  [3]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C242(0.38)  LDD2096  [3]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C242(0.83)  LDD2097  [3]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C242(0.73)  LDD2098  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C242(0.70)  LDD2099  [3]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C242(1.35)  LDD2105  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C242(1.04)  LDD2107  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C242(0.49)  LDD2109  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C242(0.86)  LDD2111  [3]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C242(0.36)  LDD2115  [3]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C242(0.84)  LDD2116  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C242(2.81)  LDD2119  [3]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C242(0.67)  LDD2122  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C242(0.61)  LDD2123  [3]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C242(0.56)  LDD2124  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C242(0.55)  LDD2125  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C242(0.90)  LDD2127  [3]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C242(1.03)  LDD2128  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C242(0.89)  LDD2129  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C242(1.05)  LDD2135  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C242(0.97)  LDD2137  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C242(0.75)  LDD2140  [3]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C242(2.92)  LDD2144  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C242(0.64)  LDD2146  [3]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C242(0.41)  LDD2148  [3]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C242(0.31)  LDD2150  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MyoD family inhibitor (MDFI) MDFI family Q99750
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Keratin-associated protein 12-3 (KRTAP12-3) KRTAP type 12 family P60328
Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) NOTCH family Q7Z3S9

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
10 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
11 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840