Details of the Target

General Information of Target

Target ID LDTP14063
Target Name Lysyl oxidase homolog 2 (LOXL2)
Gene Name LOXL2
Gene ID 4017
Synonyms
Lysyl oxidase homolog 2; EC 1.4.3.13; Lysyl oxidase-like protein 2; Lysyl oxidase-related protein 2; Lysyl oxidase-related protein WS9-14
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MIEDSGKRGNTMAERRQLFAEMRAQDLDRIRLSTYRTACKLRFVQKKCNLHLVDIWNVIE
ALRENALNNLDPNTELNVSRLEAVLSTIFYQLNKRMPTTHQIHVEQSISLLLNFLLAAFD
PEGHGKISVFAVKMALATLCGGKIMDKLRYIFSMISDSSGVMVYGRYDQFLREVLKLPTA
VFEGPSFGYTEQSARSCFSQQKKVTLNGFLDTLMSDPPPQCLVWLPLLHRLANVENVFHP
VECSYCHSESMMGFRYRCQQCHNYQLCQDCFWRGHAGGSHSNQHQMKEYTSWKSPAKKLT
NALSKSLSCASSREPLHPMFPDQPEKPLNLAHIVDTWPPRPVTSMNDTLFSHSVPSSGSP
FITRSSPPKDSEVEQNKLLARAAPAFLKGKGIQYSLNVADRLADEHVLIGLYVNMLRNNP
SCMLESSNRLDEEHRLIARYAARLAAESSSSQPPQQRSAPDISFTIDANKQQRQLIAELE
NKNREILQEIQRLRLEHEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRR
ELMVQLEGLMKLLKTQGAGSPRSSPSHTISRPIPMPIRSASACSTPTHTPQDSLTGVGGD
VQEAFAQSSRRNLRNDLLVAADSITNTMSSLVKELNSEVGSETESNVDSEFARTQFEDLV
PSPTSEKAFLAQIHARKPGYIHSGATTSTMRGDMVTEDADPYVQPEDENYENDSVRQLEN
ELQMEEYLKQKLQDEAYQVSLQG
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Lysyl oxidase family
Subcellular location
Secreted, extracellular space, extracellular matrix, basement membrane
Function
Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). Acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Shows no activity against histone H3 when it is trimethylated on 'Lys-9' (H3K9me3) or 'Lys-27' (H3K27me3) or when 'Lys-4' is monomethylated (H3K4me1) or dimethylated (H3K4me2). Also mediates deamination of methylated TAF10, a member of the transcription factor IID (TFIID) complex, which induces release of TAF10 from promoters, leading to inhibition of TFIID-dependent transcription. LOXL2-mediated deamination of TAF10 results in transcriptional repression of genes required for embryonic stem cell pluripotency including POU5F1/OCT4, NANOG, KLF4 and SOX2. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E-cadherin CDH1, probably by mediating deamination of histone H3. During EMT, involved with SNAI1 in negatively regulating pericentromeric heterochromatin transcription. SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits. Interacts with the endoplasmic reticulum protein HSPA5 which activates the IRE1-XBP1 pathway of the unfolded protein response, leading to expression of several transcription factors involved in EMT and subsequent EMT induction. Involved in E-cadherin repression following hypoxia, a hallmark of EMT believed to amplify tumor aggressiveness, suggesting that it may play a role in tumor progression. When secreted into the extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation.
TTD ID
T25637
Uniprot ID
Q9Y4K0
DrugMap ID
TTFSUHX
Ensemble ID
ENST00000389131.8
HGNC ID
HGNC:6666
ChEMBL ID
CHEMBL3714029

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K220(10.00); K248(10.00)  LDD0277  [1]
DBIA
 Probe Info  		C424(2.91); C414(1.72); C625(1.65); C158(4.17)  LDD3323  [2]
IPM
 Probe Info  		C424(2.96); C395(2.75); C414(2.27)  LDD1701  [3]
Acrolein
 Probe Info  		N.A.  LDD0222  [4]
m-APA
 Probe Info  		H416(0.00); H604(0.00); H389(0.00)  LDD2232  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [6]
NAIA_5
 Probe Info  		N.A.  LDD2225  [6]
WYneN
 Probe Info  		N.A.  LDD0021  [7]
Methacrolein
 Probe Info  		N.A.  LDD0218  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C414(0.69); C657(1.34); C663(1.34); C625(1.08)  LDD1093  [8]
 LDCM0215  AC10 PaTu 8988t C657(1.11); C663(1.11); C625(1.17); C673(1.45)  LDD1094  [8]
 LDCM0216  AC100 PaTu 8988t C657(1.24); C663(1.24); C625(1.11); C673(1.40)  LDD1095  [8]
 LDCM0217  AC101 PaTu 8988t C657(1.29); C663(1.29); C625(1.08); C673(1.36)  LDD1096  [8]
 LDCM0218  AC102 PaTu 8988t C657(1.19); C663(1.19); C625(1.03); C673(1.34)  LDD1097  [8]
 LDCM0219  AC103 PaTu 8988t C657(1.12); C663(1.12); C625(1.22); C673(1.02)  LDD1098  [8]
 LDCM0220  AC104 PaTu 8988t C657(0.93); C663(0.93); C625(1.00); C673(0.95)  LDD1099  [8]
 LDCM0221  AC105 PaTu 8988t C657(0.95); C663(0.95); C625(1.06); C673(1.13)  LDD1100  [8]
 LDCM0222  AC106 PaTu 8988t C657(1.20); C663(1.20); C625(1.10); C673(1.13)  LDD1101  [8]
 LDCM0223  AC107 PaTu 8988t C657(1.36); C663(1.36); C625(1.15); C673(1.28)  LDD1102  [8]
 LDCM0224  AC108 PaTu 8988t C657(1.25); C663(1.25); C625(0.98); C673(1.25)  LDD1103  [8]
 LDCM0225  AC109 PaTu 8988t C657(1.28); C663(1.28); C625(1.11); C673(1.49)  LDD1104  [8]
 LDCM0226  AC11 PaTu 8988t C657(1.18); C663(1.18); C625(1.23); C673(1.38)  LDD1105  [8]
 LDCM0227  AC110 PaTu 8988t C657(1.40); C663(1.40); C625(1.38); C673(1.30)  LDD1106  [8]
 LDCM0228  AC111 PaTu 8988t C657(1.15); C663(1.15); C625(1.37); C673(1.76)  LDD1107  [8]
 LDCM0229  AC112 PaTu 8988t C657(1.19); C663(1.19); C625(1.16); C673(1.15)  LDD1108  [8]
 LDCM0230  AC113 PaTu 8988t C657(0.87); C663(0.87); C625(0.90); C673(1.05)  LDD1109  [8]
 LDCM0231  AC114 PaTu 8988t C657(0.80); C663(0.80); C625(1.04); C673(1.05)  LDD1110  [8]
 LDCM0232  AC115 PaTu 8988t C657(0.65); C663(0.65); C625(1.04); C673(1.24)  LDD1111  [8]
 LDCM0233  AC116 PaTu 8988t C657(0.86); C663(0.86); C625(1.06); C673(1.07)  LDD1112  [8]
 LDCM0234  AC117 PaTu 8988t C657(0.81); C663(0.81); C625(1.09); C673(1.02)  LDD1113  [8]
 LDCM0235  AC118 PaTu 8988t C657(1.01); C663(1.01); C625(0.96); C673(0.86)  LDD1114  [8]
 LDCM0236  AC119 PaTu 8988t C657(0.84); C663(0.84); C625(1.05); C673(1.01)  LDD1115  [8]
 LDCM0237  AC12 PaTu 8988t C657(1.18); C663(1.18); C625(1.25); C673(1.31)  LDD1116  [8]
 LDCM0238  AC120 PaTu 8988t C657(0.85); C663(0.85); C625(0.93); C673(1.20)  LDD1117  [8]
 LDCM0239  AC121 PaTu 8988t C657(0.91); C663(0.91); C625(1.16); C673(1.12)  LDD1118  [8]
 LDCM0240  AC122 PaTu 8988t C657(1.05); C663(1.05); C625(0.99); C673(1.05)  LDD1119  [8]
 LDCM0241  AC123 PaTu 8988t C657(0.96); C663(0.96); C625(0.86); C673(1.04)  LDD1120  [8]
 LDCM0242  AC124 PaTu 8988t C657(1.13); C663(1.13); C625(1.05); C673(1.26)  LDD1121  [8]
 LDCM0243  AC125 PaTu 8988t C657(0.99); C663(0.99); C625(0.94); C673(1.18)  LDD1122  [8]
 LDCM0244  AC126 PaTu 8988t C657(1.03); C663(1.03); C625(1.01); C673(1.07)  LDD1123  [8]
 LDCM0245  AC127 PaTu 8988t C657(0.97); C663(0.97); C625(1.04); C673(1.08)  LDD1124  [8]
 LDCM0246  AC128 PaTu 8988t C414(1.09); C625(0.96); C673(1.13); C685(1.24)  LDD1125  [8]
 LDCM0247  AC129 PaTu 8988t C414(0.72); C625(1.39); C673(1.21); C685(1.23)  LDD1126  [8]
 LDCM0249  AC130 PaTu 8988t C414(0.87); C625(1.36); C673(1.08); C685(1.18)  LDD1128  [8]
 LDCM0250  AC131 PaTu 8988t C414(0.81); C625(1.46); C673(1.27); C685(1.32)  LDD1129  [8]
 LDCM0251  AC132 PaTu 8988t C414(0.75); C625(1.39); C673(1.02); C685(1.10)  LDD1130  [8]
 LDCM0252  AC133 PaTu 8988t C414(0.69); C625(2.01); C673(1.47); C685(1.55)  LDD1131  [8]
 LDCM0253  AC134 PaTu 8988t C414(0.85); C625(1.79); C673(1.23); C685(1.25)  LDD1132  [8]
 LDCM0254  AC135 PaTu 8988t C414(0.61); C625(1.69); C673(1.28); C685(1.39)  LDD1133  [8]
 LDCM0255  AC136 PaTu 8988t C414(0.71); C625(1.37); C673(1.42); C685(1.45)  LDD1134  [8]
 LDCM0256  AC137 PaTu 8988t C414(0.68); C625(1.75); C673(1.16); C685(1.21)  LDD1135  [8]
 LDCM0257  AC138 PaTu 8988t C414(0.73); C625(1.21); C673(1.10); C685(1.09)  LDD1136  [8]
 LDCM0258  AC139 PaTu 8988t C414(0.78); C625(1.54); C673(1.20); C685(1.30)  LDD1137  [8]
 LDCM0259  AC14 PaTu 8988t C657(0.96); C663(0.96); C625(1.07); C673(1.34)  LDD1138  [8]
 LDCM0260  AC140 PaTu 8988t C414(0.80); C625(1.07); C673(1.35); C685(1.32)  LDD1139  [8]
 LDCM0261  AC141 PaTu 8988t C414(0.81); C625(1.43); C673(1.05); C685(1.09)  LDD1140  [8]
 LDCM0262  AC142 PaTu 8988t C414(0.69); C625(1.33); C673(1.18); C685(1.19)  LDD1141  [8]
 LDCM0263  AC143 PaTu 8988t C657(1.36); C663(1.36); C625(1.20); C673(1.35)  LDD1142  [8]
 LDCM0264  AC144 PaTu 8988t C657(1.58); C663(1.58); C625(1.19); C673(1.75)  LDD1143  [8]
 LDCM0265  AC145 PaTu 8988t C657(1.50); C663(1.50); C625(1.13); C673(1.46)  LDD1144  [8]
 LDCM0266  AC146 PaTu 8988t C657(1.52); C663(1.52); C625(0.80); C673(1.39)  LDD1145  [8]
 LDCM0267  AC147 PaTu 8988t C657(1.26); C663(1.26); C625(1.06); C673(1.41)  LDD1146  [8]
 LDCM0268  AC148 PaTu 8988t C657(1.35); C663(1.35); C625(1.28); C673(1.52)  LDD1147  [8]
 LDCM0269  AC149 PaTu 8988t C657(1.92); C663(1.92); C625(1.21); C673(1.66)  LDD1148  [8]
 LDCM0270  AC15 PaTu 8988t C657(1.39); C663(1.39); C625(1.33); C673(1.63)  LDD1149  [8]
 LDCM0271  AC150 PaTu 8988t C657(1.50); C663(1.50); C625(1.29); C673(2.11)  LDD1150  [8]
 LDCM0272  AC151 PaTu 8988t C657(2.12); C663(2.12); C625(1.27); C673(2.70)  LDD1151  [8]
 LDCM0273  AC152 PaTu 8988t C657(2.86); C663(2.86); C625(1.13); C673(2.04)  LDD1152  [8]
 LDCM0274  AC153 PaTu 8988t C657(2.50); C663(2.50); C625(1.32); C673(2.19)  LDD1153  [8]
 LDCM0621  AC154 PaTu 8988t C657(2.33); C663(2.33); C625(1.26); C673(2.26)  LDD2166  [8]
 LDCM0622  AC155 PaTu 8988t C657(2.22); C663(2.22); C625(1.05); C673(2.38)  LDD2167  [8]
 LDCM0623  AC156 PaTu 8988t C657(1.64); C663(1.64); C625(1.28); C673(2.15)  LDD2168  [8]
 LDCM0624  AC157 PaTu 8988t C657(2.12); C663(2.12); C625(0.83); C673(1.91)  LDD2169  [8]
 LDCM0276  AC17 PaTu 8988t C414(1.23); C625(0.90); C673(1.47); C685(1.14)  LDD1155  [8]
 LDCM0277  AC18 PaTu 8988t C414(1.36); C625(1.10); C673(2.12); C685(1.66)  LDD1156  [8]
 LDCM0278  AC19 PaTu 8988t C414(1.43); C625(0.87); C673(1.42); C685(1.40)  LDD1157  [8]
 LDCM0279  AC2 PaTu 8988t C414(0.83); C657(1.24); C663(1.24); C625(0.83)  LDD1158  [8]
 LDCM0280  AC20 PaTu 8988t C414(1.48); C625(1.28); C673(1.70); C685(1.51)  LDD1159  [8]
 LDCM0281  AC21 PaTu 8988t C414(0.91); C625(1.11); C673(1.44); C685(1.30)  LDD1160  [8]
 LDCM0282  AC22 PaTu 8988t C414(0.80); C625(1.14); C673(1.44); C685(1.57)  LDD1161  [8]
 LDCM0283  AC23 PaTu 8988t C414(0.97); C625(1.47); C673(1.94); C685(1.72)  LDD1162  [8]
 LDCM0284  AC24 PaTu 8988t C414(2.49); C625(1.51); C673(1.28); C685(1.32)  LDD1163  [8]
 LDCM0285  AC25 PaTu 8988t C414(0.85); C657(1.02); C663(1.02); C625(1.00)  LDD1164  [8]
 LDCM0286  AC26 PaTu 8988t C414(0.68); C657(0.95); C663(0.95); C625(1.15)  LDD1165  [8]
 LDCM0287  AC27 PaTu 8988t C414(0.81); C657(0.89); C663(0.89); C625(1.22)  LDD1166  [8]
 LDCM0288  AC28 PaTu 8988t C414(0.82); C657(1.13); C663(1.13); C625(1.34)  LDD1167  [8]
 LDCM0289  AC29 PaTu 8988t C414(0.81); C657(0.98); C663(0.98); C625(1.05)  LDD1168  [8]
 LDCM0290  AC3 PaTu 8988t C414(0.98); C657(1.12); C663(1.12); C625(0.85)  LDD1169  [8]
 LDCM0291  AC30 PaTu 8988t C414(1.00); C657(0.84); C663(0.84); C625(0.93)  LDD1170  [8]
 LDCM0292  AC31 PaTu 8988t C414(0.98); C657(0.75); C663(0.75); C625(0.96)  LDD1171  [8]
 LDCM0293  AC32 PaTu 8988t C414(0.84); C657(0.95); C663(0.95); C625(0.97)  LDD1172  [8]
 LDCM0294  AC33 PaTu 8988t C414(0.86); C657(1.31); C663(1.31); C625(1.25)  LDD1173  [8]
 LDCM0295  AC34 PaTu 8988t C414(0.60); C657(1.17); C663(1.17); C625(1.09)  LDD1174  [8]
 LDCM0296  AC35 PaTu 8988t C414(1.20); C657(1.01); C663(1.01); C625(1.06)  LDD1175  [8]
 LDCM0297  AC36 PaTu 8988t C414(1.26); C657(1.21); C663(1.21); C625(1.14)  LDD1176  [8]
 LDCM0298  AC37 PaTu 8988t C414(1.36); C657(1.19); C663(1.19); C625(1.23)  LDD1177  [8]
 LDCM0299  AC38 PaTu 8988t C414(1.19); C657(1.39); C663(1.39); C625(1.43)  LDD1178  [8]
 LDCM0300  AC39 PaTu 8988t C414(1.19); C657(1.41); C663(1.41); C625(1.36)  LDD1179  [8]
 LDCM0301  AC4 PaTu 8988t C414(0.79); C657(0.96); C663(0.96); C625(0.77)  LDD1180  [8]
 LDCM0302  AC40 PaTu 8988t C414(1.15); C657(1.62); C663(1.62); C625(1.56)  LDD1181  [8]
 LDCM0303  AC41 PaTu 8988t C414(0.95); C657(1.28); C663(1.28); C625(1.11)  LDD1182  [8]
 LDCM0304  AC42 PaTu 8988t C414(0.88); C657(1.36); C663(1.36); C625(1.38)  LDD1183  [8]
 LDCM0305  AC43 PaTu 8988t C414(1.11); C657(1.61); C663(1.61); C625(1.19)  LDD1184  [8]
 LDCM0306  AC44 PaTu 8988t C414(1.09); C657(2.00); C663(2.00); C625(2.09)  LDD1185  [8]
 LDCM0307  AC45 PaTu 8988t C414(1.52); C657(1.66); C663(1.66); C625(1.44)  LDD1186  [8]
 LDCM0308  AC46 PaTu 8988t C414(1.02); C657(1.58); C663(1.58); C625(1.20)  LDD1187  [8]
 LDCM0309  AC47 PaTu 8988t C414(0.97); C657(1.21); C663(1.21); C625(1.16)  LDD1188  [8]
 LDCM0310  AC48 PaTu 8988t C414(0.97); C657(1.53); C663(1.53); C625(1.44)  LDD1189  [8]
 LDCM0311  AC49 PaTu 8988t C414(0.88); C657(1.77); C663(1.77); C625(1.49)  LDD1190  [8]
 LDCM0312  AC5 PaTu 8988t C414(0.76); C657(1.14); C663(1.14); C625(0.98)  LDD1191  [8]
 LDCM0313  AC50 PaTu 8988t C414(1.28); C657(1.74); C663(1.74); C625(1.50)  LDD1192  [8]
 LDCM0314  AC51 PaTu 8988t C414(1.01); C657(0.87); C663(0.87); C625(0.79)  LDD1193  [8]
 LDCM0315  AC52 PaTu 8988t C414(0.92); C657(1.51); C663(1.51); C625(1.22)  LDD1194  [8]
 LDCM0316  AC53 PaTu 8988t C414(0.98); C657(2.07); C663(2.07); C625(1.51)  LDD1195  [8]
 LDCM0317  AC54 PaTu 8988t C414(0.79); C657(2.08); C663(2.08); C625(1.97)  LDD1196  [8]
 LDCM0318  AC55 PaTu 8988t C414(1.07); C657(1.36); C663(1.36); C625(1.26)  LDD1197  [8]
 LDCM0319  AC56 PaTu 8988t C414(0.94); C657(1.53); C663(1.53); C625(1.50)  LDD1198  [8]
 LDCM0320  AC57 PaTu 8988t C657(1.44); C663(1.44); C673(1.08); C685(1.08)  LDD1199  [8]
 LDCM0321  AC58 PaTu 8988t C657(1.24); C663(1.24); C673(1.00); C685(0.96)  LDD1200  [8]
 LDCM0322  AC59 PaTu 8988t C657(1.15); C663(1.15); C673(0.98); C685(0.87)  LDD1201  [8]
 LDCM0323  AC6 PaTu 8988t C657(1.10); C663(1.10); C625(0.92); C673(1.09)  LDD1202  [8]
 LDCM0324  AC60 PaTu 8988t C657(1.17); C663(1.17); C673(1.04); C685(1.02)  LDD1203  [8]
 LDCM0325  AC61 PaTu 8988t C657(1.13); C663(1.13); C673(0.94); C685(0.95)  LDD1204  [8]
 LDCM0326  AC62 PaTu 8988t C657(1.05); C663(1.05); C673(1.04); C685(1.01)  LDD1205  [8]
 LDCM0327  AC63 PaTu 8988t C657(1.15); C663(1.15); C673(1.03); C685(1.04)  LDD1206  [8]
 LDCM0328  AC64 PaTu 8988t C657(1.18); C663(1.18); C673(1.07); C685(1.03)  LDD1207  [8]
 LDCM0329  AC65 PaTu 8988t C657(1.08); C663(1.08); C673(0.90); C685(0.94)  LDD1208  [8]
 LDCM0330  AC66 PaTu 8988t C657(1.20); C663(1.20); C673(0.93); C685(0.89)  LDD1209  [8]
 LDCM0331  AC67 PaTu 8988t C657(1.12); C663(1.12); C673(1.22); C685(1.09)  LDD1210  [8]
 LDCM0332  AC68 PaTu 8988t C414(1.18); C657(1.08); C663(1.08); C625(0.90)  LDD1211  [8]
 LDCM0333  AC69 PaTu 8988t C414(1.23); C657(1.24); C663(1.24); C625(1.03)  LDD1212  [8]
 LDCM0334  AC7 PaTu 8988t C657(1.28); C663(1.28); C625(1.22); C673(1.20)  LDD1213  [8]
 LDCM0335  AC70 PaTu 8988t C414(1.09); C657(1.14); C663(1.14); C625(0.94)  LDD1214  [8]
 LDCM0336  AC71 PaTu 8988t C414(1.22); C657(0.98); C663(0.98); C625(0.94)  LDD1215  [8]
 LDCM0337  AC72 PaTu 8988t C414(1.17); C657(1.01); C663(1.01); C625(0.88)  LDD1216  [8]
 LDCM0338  AC73 PaTu 8988t C414(1.14); C657(1.05); C663(1.05); C625(0.90)  LDD1217  [8]
 LDCM0339  AC74 PaTu 8988t C414(1.66); C657(1.11); C663(1.11); C625(0.91)  LDD1218  [8]
 LDCM0340  AC75 PaTu 8988t C414(2.21); C657(1.19); C663(1.19); C625(1.02)  LDD1219  [8]
 LDCM0341  AC76 PaTu 8988t C414(1.09); C657(1.12); C663(1.12); C625(0.88)  LDD1220  [8]
 LDCM0342  AC77 PaTu 8988t C414(1.53); C657(1.15); C663(1.15); C625(1.01)  LDD1221  [8]
 LDCM0343  AC78 PaTu 8988t C414(1.10); C657(1.16); C663(1.16); C625(0.96)  LDD1222  [8]
 LDCM0344  AC79 PaTu 8988t C414(0.95); C657(1.15); C663(1.15); C625(1.07)  LDD1223  [8]
 LDCM0345  AC8 PaTu 8988t C657(0.93); C663(0.93); C625(0.96); C673(1.02)  LDD1224  [8]
 LDCM0346  AC80 PaTu 8988t C414(1.24); C657(1.11); C663(1.11); C625(0.98)  LDD1225  [8]
 LDCM0347  AC81 PaTu 8988t C414(1.16); C657(1.03); C663(1.03); C625(1.38)  LDD1226  [8]
 LDCM0348  AC82 PaTu 8988t C414(1.29); C657(1.24); C663(1.24); C625(0.96)  LDD1227  [8]
 LDCM0349  AC83 PaTu 8988t C673(0.81); C685(0.96)  LDD1228  [8]
 LDCM0350  AC84 PaTu 8988t C673(0.82); C685(0.96)  LDD1229  [8]
 LDCM0351  AC85 PaTu 8988t C673(0.92); C685(0.89)  LDD1230  [8]
 LDCM0352  AC86 PaTu 8988t C673(0.75); C685(0.88)  LDD1231  [8]
 LDCM0353  AC87 PaTu 8988t C673(0.82); C685(1.03)  LDD1232  [8]
 LDCM0354  AC88 PaTu 8988t C673(0.99); C685(0.95)  LDD1233  [8]
 LDCM0355  AC89 PaTu 8988t C673(1.04); C685(0.92)  LDD1234  [8]
 LDCM0357  AC90 PaTu 8988t C673(0.66); C685(0.82)  LDD1236  [8]
 LDCM0358  AC91 PaTu 8988t C673(0.95); C685(0.94)  LDD1237  [8]
 LDCM0359  AC92 PaTu 8988t C673(1.10); C685(1.02)  LDD1238  [8]
 LDCM0360  AC93 PaTu 8988t C673(0.68); C685(0.71)  LDD1239  [8]
 LDCM0361  AC94 PaTu 8988t C673(0.74); C685(0.93)  LDD1240  [8]
 LDCM0362  AC95 PaTu 8988t C673(0.83); C685(0.87)  LDD1241  [8]
 LDCM0363  AC96 PaTu 8988t C673(0.60); C685(0.79)  LDD1242  [8]
 LDCM0364  AC97 PaTu 8988t C673(0.61); C685(0.75)  LDD1243  [8]
 LDCM0365  AC98 PaTu 8988t C657(1.14); C663(1.14); C625(0.97); C673(1.06)  LDD1244  [8]
 LDCM0366  AC99 PaTu 8988t C657(1.04); C663(1.04); C625(1.03); C673(1.09)  LDD1245  [8]
 LDCM0248  AKOS034007472 PaTu 8988t C657(1.19); C663(1.19); C625(1.06); C673(1.49)  LDD1127  [8]
 LDCM0356  AKOS034007680 PaTu 8988t C657(1.20); C663(1.20); C625(1.78); C673(1.65)  LDD1235  [8]
 LDCM0275  AKOS034007705 PaTu 8988t C657(1.22); C663(1.22); C625(1.26); C673(1.40)  LDD1154  [8]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [4]
 LDCM0367  CL1 PaTu 8988t C657(1.22); C663(1.22); C625(0.97); C673(1.12)  LDD1246  [8]
 LDCM0368  CL10 PaTu 8988t C657(1.69); C663(1.69); C625(1.05); C673(1.30)  LDD1247  [8]
 LDCM0369  CL100 PaTu 8988t C414(0.66); C657(1.07); C663(1.07); C625(0.76)  LDD1248  [8]
 LDCM0370  CL101 PaTu 8988t C657(1.03); C663(1.03); C625(1.01); C673(1.18)  LDD1249  [8]
 LDCM0371  CL102 PaTu 8988t C657(1.27); C663(1.27); C625(1.10); C673(1.21)  LDD1250  [8]
 LDCM0372  CL103 PaTu 8988t C657(1.34); C663(1.34); C625(1.15); C673(1.36)  LDD1251  [8]
 LDCM0373  CL104 PaTu 8988t C657(0.95); C663(0.95); C625(1.27); C673(1.14)  LDD1252  [8]
 LDCM0374  CL105 PaTu 8988t C414(1.17); C625(1.14); C673(1.38); C685(1.45)  LDD1253  [8]
 LDCM0375  CL106 PaTu 8988t C414(1.30); C625(1.12); C673(1.32); C685(1.23)  LDD1254  [8]
 LDCM0376  CL107 PaTu 8988t C414(1.78); C625(0.96); C673(1.36); C685(1.16)  LDD1255  [8]
 LDCM0377  CL108 PaTu 8988t C414(1.59); C625(1.22); C673(1.43); C685(1.19)  LDD1256  [8]
 LDCM0378  CL109 PaTu 8988t C414(1.21); C625(1.17); C673(1.77); C685(1.67)  LDD1257  [8]
 LDCM0379  CL11 PaTu 8988t C657(1.23); C663(1.23); C625(1.04); C673(1.17)  LDD1258  [8]
 LDCM0380  CL110 PaTu 8988t C414(0.77); C625(1.21); C673(1.42); C685(1.23)  LDD1259  [8]
 LDCM0381  CL111 PaTu 8988t C414(0.96); C625(1.39); C673(1.84); C685(1.58)  LDD1260  [8]
 LDCM0382  CL112 PaTu 8988t C414(0.81); C657(1.07); C663(1.07); C625(0.96)  LDD1261  [8]
 LDCM0383  CL113 PaTu 8988t C414(0.96); C657(1.01); C663(1.01); C625(1.04)  LDD1262  [8]
 LDCM0384  CL114 PaTu 8988t C414(1.14); C657(1.07); C663(1.07); C625(1.00)  LDD1263  [8]
 LDCM0385  CL115 PaTu 8988t C414(0.87); C657(0.97); C663(0.97); C625(0.97)  LDD1264  [8]
 LDCM0386  CL116 PaTu 8988t C414(0.81); C657(1.02); C663(1.02); C625(0.99)  LDD1265  [8]
 LDCM0387  CL117 PaTu 8988t C414(0.81); C657(1.09); C663(1.09); C625(1.28)  LDD1266  [8]
 LDCM0388  CL118 PaTu 8988t C414(1.03); C657(1.44); C663(1.44); C625(1.17)  LDD1267  [8]
 LDCM0389  CL119 PaTu 8988t C414(0.88); C657(1.36); C663(1.36); C625(1.21)  LDD1268  [8]
 LDCM0390  CL12 PaTu 8988t C657(1.52); C663(1.52); C625(1.26); C673(1.28)  LDD1269  [8]
 LDCM0391  CL120 PaTu 8988t C414(1.06); C657(1.17); C663(1.17); C625(1.29)  LDD1270  [8]
 LDCM0392  CL121 PaTu 8988t C414(1.05); C657(1.59); C663(1.59); C625(1.29)  LDD1271  [8]
 LDCM0393  CL122 PaTu 8988t C414(1.34); C657(1.44); C663(1.44); C625(1.37)  LDD1272  [8]
 LDCM0394  CL123 PaTu 8988t C414(0.87); C657(1.66); C663(1.66); C625(1.33)  LDD1273  [8]
 LDCM0395  CL124 PaTu 8988t C414(0.81); C657(1.66); C663(1.66); C625(1.56)  LDD1274  [8]
 LDCM0396  CL125 PaTu 8988t C657(1.26); C663(1.26); C673(0.87); C685(0.85)  LDD1275  [8]
 LDCM0397  CL126 PaTu 8988t C657(1.13); C663(1.13); C673(0.72); C685(0.68)  LDD1276  [8]
 LDCM0398  CL127 PaTu 8988t C657(1.29); C663(1.29); C673(0.92); C685(0.85)  LDD1277  [8]
 LDCM0399  CL128 PaTu 8988t C657(1.35); C663(1.35); C673(0.89); C685(0.98)  LDD1278  [8]
 LDCM0400  CL13 PaTu 8988t C657(1.64); C663(1.64); C625(1.05); C673(1.43)  LDD1279  [8]
 LDCM0401  CL14 PaTu 8988t C657(2.18); C663(2.18); C625(1.35); C673(1.89)  LDD1280  [8]
 LDCM0402  CL15 PaTu 8988t C657(1.53); C663(1.53); C625(1.29); C673(1.19)  LDD1281  [8]
 LDCM0403  CL16 PaTu 8988t C657(1.11); C663(1.11); C625(1.13); C673(1.02)  LDD1282  [8]
 LDCM0404  CL17 PaTu 8988t C657(0.92); C663(0.92); C625(0.88); C673(1.04)  LDD1283  [8]
 LDCM0405  CL18 PaTu 8988t C657(1.15); C663(1.15); C625(1.27); C673(1.30)  LDD1284  [8]
 LDCM0406  CL19 PaTu 8988t C657(1.07); C663(1.07); C625(1.03); C673(1.37)  LDD1285  [8]
 LDCM0407  CL2 PaTu 8988t C657(1.53); C663(1.53); C625(1.13); C673(1.18)  LDD1286  [8]
 LDCM0408  CL20 PaTu 8988t C657(1.13); C663(1.13); C625(1.14); C673(1.30)  LDD1287  [8]
 LDCM0409  CL21 PaTu 8988t C657(1.38); C663(1.38); C625(1.23); C673(1.09)  LDD1288  [8]
 LDCM0410  CL22 PaTu 8988t C657(1.49); C663(1.49); C625(1.13); C673(1.30)  LDD1289  [8]
 LDCM0411  CL23 PaTu 8988t C657(0.84); C663(0.84); C625(1.27); C673(1.48)  LDD1290  [8]
 LDCM0412  CL24 PaTu 8988t C657(1.17); C663(1.17); C625(1.22); C673(0.93)  LDD1291  [8]
 LDCM0413  CL25 PaTu 8988t C657(1.12); C663(1.12); C625(1.15); C673(1.04)  LDD1292  [8]
 LDCM0414  CL26 PaTu 8988t C657(1.01); C663(1.01); C625(1.18); C673(1.09)  LDD1293  [8]
 LDCM0415  CL27 PaTu 8988t C657(1.49); C663(1.49); C625(1.53); C673(1.41)  LDD1294  [8]
 LDCM0416  CL28 PaTu 8988t C657(1.31); C663(1.31); C625(1.26); C673(1.49)  LDD1295  [8]
 LDCM0417  CL29 PaTu 8988t C657(0.98); C663(0.98); C625(1.08); C673(1.30)  LDD1296  [8]
 LDCM0418  CL3 PaTu 8988t C657(1.79); C663(1.79); C625(1.22); C673(1.85)  LDD1297  [8]
 LDCM0419  CL30 PaTu 8988t C657(0.88); C663(0.88); C625(1.22); C673(0.99)  LDD1298  [8]
 LDCM0420  CL31 PaTu 8988t C657(1.21); C663(1.34); C625(1.04); C673(1.30)  LDD1299  [8]
 LDCM0421  CL32 PaTu 8988t C657(1.34); C663(1.44); C625(1.32); C673(1.48)  LDD1300  [8]
 LDCM0422  CL33 PaTu 8988t C657(0.99); C663(1.07); C625(1.11); C673(1.12)  LDD1301  [8]
 LDCM0423  CL34 PaTu 8988t C657(1.35); C663(1.47); C625(1.02); C673(1.60)  LDD1302  [8]
 LDCM0424  CL35 PaTu 8988t C657(1.48); C663(1.63); C625(1.19); C673(1.69)  LDD1303  [8]
 LDCM0425  CL36 PaTu 8988t C657(1.02); C663(1.15); C625(0.37); C673(1.00)  LDD1304  [8]
 LDCM0426  CL37 PaTu 8988t C657(1.52); C663(1.68); C625(1.26); C673(1.66)  LDD1305  [8]
 LDCM0428  CL39 PaTu 8988t C657(0.96); C663(0.95); C625(1.35); C673(1.04)  LDD1307  [8]
 LDCM0429  CL4 PaTu 8988t C657(1.29); C663(1.29); C625(1.22); C673(1.51)  LDD1308  [8]
 LDCM0430  CL40 PaTu 8988t C657(1.43); C663(1.54); C625(1.13); C673(1.69)  LDD1309  [8]
 LDCM0431  CL41 PaTu 8988t C657(1.35); C663(1.47); C625(0.87); C673(1.51)  LDD1310  [8]
 LDCM0432  CL42 PaTu 8988t C657(1.63); C663(1.64); C625(1.21); C673(2.01)  LDD1311  [8]
 LDCM0433  CL43 PaTu 8988t C657(1.41); C663(1.50); C625(1.01); C673(1.73)  LDD1312  [8]
 LDCM0434  CL44 PaTu 8988t C657(1.30); C663(1.28); C625(1.38); C673(1.61)  LDD1313  [8]
 LDCM0435  CL45 PaTu 8988t C657(0.91); C663(0.91); C625(1.07); C673(1.07)  LDD1314  [8]
 LDCM0436  CL46 PaTu 8988t C414(1.07); C657(0.81); C663(0.81); C625(0.89)  LDD1315  [8]
 LDCM0437  CL47 PaTu 8988t C414(1.02); C657(0.78); C663(0.78); C625(0.90)  LDD1316  [8]
 LDCM0438  CL48 PaTu 8988t C414(1.03); C657(1.07); C663(1.07); C625(0.93)  LDD1317  [8]
 LDCM0439  CL49 PaTu 8988t C414(1.13); C657(0.79); C663(0.79); C625(0.93)  LDD1318  [8]
 LDCM0440  CL5 PaTu 8988t C657(2.05); C663(2.05); C625(1.09); C673(1.81)  LDD1319  [8]
 LDCM0441  CL50 PaTu 8988t C414(1.08); C657(1.15); C663(1.15); C625(1.02)  LDD1320  [8]
 LDCM0442  CL51 PaTu 8988t C414(0.93); C657(0.82); C663(0.82); C625(1.10)  LDD1321  [8]
 LDCM0443  CL52 PaTu 8988t C414(1.00); C657(0.77); C663(0.77); C625(1.05)  LDD1322  [8]
 LDCM0444  CL53 PaTu 8988t C414(0.86); C657(0.86); C663(0.86); C625(0.97)  LDD1323  [8]
 LDCM0445  CL54 PaTu 8988t C414(1.04); C657(0.73); C663(0.73); C625(0.81)  LDD1324  [8]
 LDCM0446  CL55 PaTu 8988t C414(1.12); C657(1.18); C663(1.18); C625(1.28)  LDD1325  [8]
 LDCM0447  CL56 PaTu 8988t C414(0.45); C657(1.01); C663(1.01); C625(0.91)  LDD1326  [8]
 LDCM0448  CL57 PaTu 8988t C414(0.73); C657(0.72); C663(0.72); C625(1.04)  LDD1327  [8]
 LDCM0449  CL58 PaTu 8988t C414(0.64); C657(0.82); C663(0.82); C625(1.08)  LDD1328  [8]
 LDCM0450  CL59 PaTu 8988t C414(0.69); C657(0.79); C663(0.79); C625(0.98)  LDD1329  [8]
 LDCM0451  CL6 PaTu 8988t C657(2.23); C663(2.23); C625(1.09); C673(1.29)  LDD1330  [8]
 LDCM0452  CL60 PaTu 8988t C414(0.71); C657(0.76); C663(0.76); C625(0.97)  LDD1331  [8]
 LDCM0453  CL61 PaTu 8988t C414(1.10); C657(1.12); C663(1.12); C625(1.17)  LDD1332  [8]
 LDCM0454  CL62 PaTu 8988t C414(1.40); C657(1.23); C663(1.23); C625(1.19)  LDD1333  [8]
 LDCM0455  CL63 PaTu 8988t C414(1.39); C657(1.26); C663(1.26); C625(1.21)  LDD1334  [8]
 LDCM0456  CL64 PaTu 8988t C414(1.09); C657(1.37); C663(1.37); C625(1.23)  LDD1335  [8]
 LDCM0457  CL65 PaTu 8988t C414(1.47); C657(1.17); C663(1.17); C625(1.09)  LDD1336  [8]
 LDCM0458  CL66 PaTu 8988t C414(1.06); C657(1.24); C663(1.24); C625(1.08)  LDD1337  [8]
 LDCM0459  CL67 PaTu 8988t C414(1.35); C657(1.68); C663(1.68); C625(1.41)  LDD1338  [8]
 LDCM0460  CL68 PaTu 8988t C414(1.47); C657(1.58); C663(1.58); C625(1.64)  LDD1339  [8]
 LDCM0461  CL69 PaTu 8988t C414(1.02); C657(1.60); C663(1.60); C625(1.40)  LDD1340  [8]
 LDCM0462  CL7 PaTu 8988t C657(2.13); C663(2.13); C625(1.06); C673(1.43)  LDD1341  [8]
 LDCM0463  CL70 PaTu 8988t C414(1.69); C657(1.55); C663(1.55); C625(1.42)  LDD1342  [8]
 LDCM0464  CL71 PaTu 8988t C414(1.22); C657(1.24); C663(1.24); C625(1.21)  LDD1343  [8]
 LDCM0465  CL72 PaTu 8988t C414(1.46); C657(0.99); C663(0.99); C625(1.07)  LDD1344  [8]
 LDCM0466  CL73 PaTu 8988t C414(1.31); C657(1.75); C663(1.75); C625(1.58)  LDD1345  [8]
 LDCM0467  CL74 PaTu 8988t C414(1.21); C657(1.52); C663(1.52); C625(1.17)  LDD1346  [8]
 LDCM0469  CL76 PaTu 8988t C414(1.02); C657(1.16); C663(1.16); C625(0.88)  LDD1348  [8]
 LDCM0470  CL77 PaTu 8988t C414(1.11); C657(1.34); C663(1.34); C625(1.06)  LDD1349  [8]
 LDCM0471  CL78 PaTu 8988t C414(1.28); C657(1.85); C663(1.85); C625(1.37)  LDD1350  [8]
 LDCM0472  CL79 PaTu 8988t C414(1.57); C657(1.50); C663(1.50); C625(1.32)  LDD1351  [8]
 LDCM0473  CL8 PaTu 8988t C657(1.55); C663(1.55); C625(1.01); C673(1.06)  LDD1352  [8]
 LDCM0474  CL80 PaTu 8988t C414(1.59); C657(1.53); C663(1.53); C625(1.28)  LDD1353  [8]
 LDCM0475  CL81 PaTu 8988t C414(0.95); C657(1.91); C663(1.91); C625(1.44)  LDD1354  [8]
 LDCM0476  CL82 PaTu 8988t C414(1.12); C657(2.55); C663(2.55); C625(1.28)  LDD1355  [8]
 LDCM0477  CL83 PaTu 8988t C414(1.43); C657(2.01); C663(2.01); C625(1.18)  LDD1356  [8]
 LDCM0478  CL84 PaTu 8988t C414(0.96); C657(1.57); C663(1.57); C625(1.65)  LDD1357  [8]
 LDCM0479  CL85 PaTu 8988t C414(1.11); C657(1.68); C663(1.68); C625(1.15)  LDD1358  [8]
 LDCM0480  CL86 PaTu 8988t C414(1.15); C657(1.63); C663(1.63); C625(1.24)  LDD1359  [8]
 LDCM0481  CL87 PaTu 8988t C414(1.00); C657(1.19); C663(1.19); C625(1.63)  LDD1360  [8]
 LDCM0482  CL88 PaTu 8988t C414(1.08); C657(1.70); C663(1.70); C625(1.43)  LDD1361  [8]
 LDCM0483  CL89 PaTu 8988t C414(1.22); C657(1.22); C663(1.22); C625(1.50)  LDD1362  [8]
 LDCM0484  CL9 PaTu 8988t C657(1.70); C663(1.70); C625(1.10); C673(1.75)  LDD1363  [8]
 LDCM0485  CL90 PaTu 8988t C414(0.83); C657(1.84); C663(1.84); C625(1.42)  LDD1364  [8]
 LDCM0486  CL91 PaTu 8988t C414(0.61); C657(0.95); C663(0.95); C625(0.73)  LDD1365  [8]
 LDCM0487  CL92 PaTu 8988t C414(0.59); C657(1.16); C663(1.16); C625(0.68)  LDD1366  [8]
 LDCM0488  CL93 PaTu 8988t C414(0.58); C657(1.35); C663(1.35); C625(0.84)  LDD1367  [8]
 LDCM0489  CL94 PaTu 8988t C414(0.57); C657(1.04); C663(1.04); C625(0.62)  LDD1368  [8]
 LDCM0490  CL95 PaTu 8988t C414(0.73); C657(1.24); C663(1.24); C625(0.75)  LDD1369  [8]
 LDCM0491  CL96 PaTu 8988t C414(0.76); C657(1.28); C663(1.28); C625(0.83)  LDD1370  [8]
 LDCM0492  CL97 PaTu 8988t C414(0.60); C657(1.22); C663(1.22); C625(0.77)  LDD1371  [8]
 LDCM0493  CL98 PaTu 8988t C414(0.56); C657(1.29); C663(1.29); C625(0.86)  LDD1372  [8]
 LDCM0494  CL99 PaTu 8988t C414(0.73); C657(1.06); C663(1.06); C625(0.79)  LDD1373  [8]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C424(0.96)  LDD1702  [3]
 LDCM0468  Fragment33 PaTu 8988t C414(1.16); C657(1.40); C663(1.40); C625(1.12)  LDD1347  [8]
 LDCM0427  Fragment51 PaTu 8988t C657(1.38); C663(1.42); C625(1.45); C673(1.48)  LDD1306  [8]
 LDCM0022  KB02 786-O C414(1.01)  LDD2247  [2]
 LDCM0023  KB03 MDA-MB-231 C424(2.96); C395(2.75); C414(2.27)  LDD1701  [3]
 LDCM0024  KB05 SKMEL24 C424(2.91); C414(1.72); C625(1.65); C158(4.17)  LDD3323  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MARCKS-related protein (MARCKSL1) MARCKS family P49006
Fibronectin (FN1) . P02751

The Drug(s) Related To This Target

Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Gs-6624 Antibody D09NCU
Preclinical
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Beta-aminopropionitrile Small molecular drug D7ZXE5

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.