Details of the Target

General Information of Target

Target ID LDTP13791
Target Name Lipoyl amidotransferase LIPT1, mitochondrial (LIPT1)
Gene Name LIPT1
Gene ID 51601
Synonyms
Lipoyl amidotransferase LIPT1, mitochondrial; EC 2.3.1.200; Lipoate biosynthesis protein; Lipoate-protein ligase; Lipoyl ligase; Lipoyltransferase 1; EC 2.3.1.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASLEEPLAPRPQGPLPAAGDEPGCGPGKLRPEPRLSAAGGGSAAGPGPAPEWPGRGRAE
RAAPPRPPLSSAGRPSPAGGPGALSARGGGCGWVAARAPLALAFSSRVPSSSPSFFYFWP
PPPPPPPSFLPSSSAFHLPVRLPGREGAAAAAAAGGGGDAGGGGGGGQEAAPLSVPTSSS
HRGGGGSGGGRRRLFLSPALQGLLLPARAGPRPPPPPRLPLGQAARRAGSPGFPGAGPGG
GGQTPRRPQGASFALAAAAALLFGSDMEDGPSNNASCFRRLTECFLSPSLTDEKVKAYLS
LHPQVLDEFVSESVSAETVEKWLKRKNNKSEDESAPKEVSRYQDTNMQGVVYELNSYIEQ
RLDTGGDNQLLLYELSSIIKIATKADGFALYFLGECNNSLCIFTPPGIKEGKPRLIPAGP
ITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGIL
ELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNI
VAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRF
SIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQM
VNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSE
EWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMS
VKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSY
LQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATD
LALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYA
EFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKA
CRDNLSQWEKVIRGEETATWISSPSVAQKAAASED
Target Bioclass
Enzyme
Family
LplA family
Subcellular location
Mitochondrion
Function
Lipoyl amidotransferase that catalyzes the transfer of lipoyl moieties from lipoyl-protein H of the glycine cleavage system (lipoyl-GCSH) to E2 subunits of the pyruvate dehydrogenase complex (PDCE2). Unable to catalyze the transfer of octanoyl from octanoyl-GCSH to PDCE2. In vitro, it is also able to catalyze the transfer of the lipoyl group from lipoyl-AMP to the specific lysine residue of lipoyl domains of lipoate-dependent enzymes but this reaction may not be physiologically relevant (Probable).
Uniprot ID
Q9Y234
Ensemble ID
ENST00000393471.2
HGNC ID
HGNC:29569

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C352(2.72)  LDD3330  [1]
AHL-Pu-1
 Probe Info  		C337(2.59)  LDD0171  [2]
IA-alkyne
 Probe Info  		C337(11.32)  LDD1703  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C337(2.59)  LDD0171  [2]
 LDCM0214  AC1 PaTu 8988t C84(0.42)  LDD1093  [4]
 LDCM0215  AC10 HEK-293T C310(0.84)  LDD1508  [5]
 LDCM0216  AC100 PaTu 8988t C84(0.94)  LDD1095  [4]
 LDCM0217  AC101 PaTu 8988t C84(0.95)  LDD1096  [4]
 LDCM0218  AC102 PaTu 8988t C84(1.23)  LDD1097  [4]
 LDCM0219  AC103 PaTu 8988t C84(1.18)  LDD1098  [4]
 LDCM0220  AC104 PaTu 8988t C84(0.98)  LDD1099  [4]
 LDCM0221  AC105 PaTu 8988t C84(1.62)  LDD1100  [4]
 LDCM0222  AC106 PaTu 8988t C84(0.92)  LDD1101  [4]
 LDCM0223  AC107 PaTu 8988t C84(0.96)  LDD1102  [4]
 LDCM0224  AC108 PaTu 8988t C84(1.22)  LDD1103  [4]
 LDCM0225  AC109 PaTu 8988t C84(1.08)  LDD1104  [4]
 LDCM0226  AC11 HEK-293T C352(0.93); C366(0.79)  LDD1509  [5]
 LDCM0227  AC110 PaTu 8988t C84(0.99)  LDD1106  [4]
 LDCM0228  AC111 PaTu 8988t C84(1.82)  LDD1107  [4]
 LDCM0229  AC112 PaTu 8988t C84(1.29)  LDD1108  [4]
 LDCM0237  AC12 HEK-293T C337(1.00)  LDD1510  [5]
 LDCM0246  AC128 PaTu 8988t C84(1.27)  LDD1125  [4]
 LDCM0247  AC129 PaTu 8988t C84(1.23)  LDD1126  [4]
 LDCM0249  AC130 PaTu 8988t C84(1.26)  LDD1128  [4]
 LDCM0250  AC131 PaTu 8988t C84(1.03)  LDD1129  [4]
 LDCM0251  AC132 PaTu 8988t C84(1.05)  LDD1130  [4]
 LDCM0252  AC133 PaTu 8988t C84(1.27)  LDD1131  [4]
 LDCM0253  AC134 PaTu 8988t C84(1.12)  LDD1132  [4]
 LDCM0254  AC135 PaTu 8988t C84(1.08)  LDD1133  [4]
 LDCM0255  AC136 PaTu 8988t C84(1.12)  LDD1134  [4]
 LDCM0256  AC137 PaTu 8988t C84(1.23)  LDD1135  [4]
 LDCM0257  AC138 PaTu 8988t C84(1.02)  LDD1136  [4]
 LDCM0258  AC139 PaTu 8988t C84(1.31)  LDD1137  [4]
 LDCM0259  AC14 HEK-293T C337(1.17); C366(0.85)  LDD1512  [5]
 LDCM0260  AC140 PaTu 8988t C84(1.13)  LDD1139  [4]
 LDCM0261  AC141 PaTu 8988t C84(1.42)  LDD1140  [4]
 LDCM0262  AC142 PaTu 8988t C84(0.97)  LDD1141  [4]
 LDCM0270  AC15 HEK-293T C352(1.02)  LDD1513  [5]
 LDCM0276  AC17 HEK-293T C337(0.99); C352(1.07)  LDD1515  [5]
 LDCM0277  AC18 HEK-293T C310(1.04)  LDD1516  [5]
 LDCM0278  AC19 HEK-293T C352(1.53); C366(0.70)  LDD1517  [5]
 LDCM0279  AC2 PaTu 8988t C84(0.34)  LDD1158  [4]
 LDCM0280  AC20 HEK-293T C337(1.11)  LDD1519  [5]
 LDCM0281  AC21 HEK-293T C337(1.13); C352(0.92)  LDD1520  [5]
 LDCM0282  AC22 HEK-293T C337(1.20); C366(0.95)  LDD1521  [5]
 LDCM0283  AC23 HEK-293T C352(1.01)  LDD1522  [5]
 LDCM0284  AC24 HEK-293T C337(0.89)  LDD1523  [5]
 LDCM0285  AC25 HEK-293T C337(1.05); C352(1.07)  LDD1524  [5]
 LDCM0286  AC26 HEK-293T C310(0.85)  LDD1525  [5]
 LDCM0287  AC27 HEK-293T C352(1.02); C366(0.93)  LDD1526  [5]
 LDCM0288  AC28 HEK-293T C337(1.05)  LDD1527  [5]
 LDCM0289  AC29 HEK-293T C337(1.03); C352(0.99)  LDD1528  [5]
 LDCM0290  AC3 PaTu 8988t C84(0.22)  LDD1169  [4]
 LDCM0291  AC30 HEK-293T C337(1.23); C366(0.84)  LDD1530  [5]
 LDCM0292  AC31 HEK-293T C352(1.00)  LDD1531  [5]
 LDCM0293  AC32 HEK-293T C337(0.81)  LDD1532  [5]
 LDCM0294  AC33 HEK-293T C337(0.96); C352(1.12)  LDD1533  [5]
 LDCM0295  AC34 HEK-293T C310(0.89)  LDD1534  [5]
 LDCM0296  AC35 HEK-293T C352(0.98); C366(0.94)  LDD1535  [5]
 LDCM0297  AC36 HEK-293T C337(1.13)  LDD1536  [5]
 LDCM0298  AC37 HEK-293T C337(0.98); C352(0.98)  LDD1537  [5]
 LDCM0299  AC38 HEK-293T C337(1.19); C366(0.88)  LDD1538  [5]
 LDCM0300  AC39 HEK-293T C352(1.00)  LDD1539  [5]
 LDCM0301  AC4 PaTu 8988t C84(0.27)  LDD1180  [4]
 LDCM0302  AC40 HEK-293T C337(1.05)  LDD1541  [5]
 LDCM0303  AC41 HEK-293T C337(1.20); C352(1.10)  LDD1542  [5]
 LDCM0304  AC42 HEK-293T C310(0.93)  LDD1543  [5]
 LDCM0305  AC43 HEK-293T C352(0.94); C366(0.72)  LDD1544  [5]
 LDCM0306  AC44 HEK-293T C337(0.98)  LDD1545  [5]
 LDCM0307  AC45 HEK-293T C337(0.93); C352(1.01)  LDD1546  [5]
 LDCM0308  AC46 HEK-293T C337(1.09); C366(0.94)  LDD1547  [5]
 LDCM0309  AC47 HEK-293T C352(0.98)  LDD1548  [5]
 LDCM0310  AC48 HEK-293T C337(0.96)  LDD1549  [5]
 LDCM0311  AC49 HEK-293T C337(1.08); C352(1.05)  LDD1550  [5]
 LDCM0312  AC5 PaTu 8988t C84(0.38)  LDD1191  [4]
 LDCM0313  AC50 HEK-293T C310(1.06)  LDD1552  [5]
 LDCM0314  AC51 HEK-293T C352(1.03); C366(0.93)  LDD1553  [5]
 LDCM0315  AC52 HEK-293T C337(0.99)  LDD1554  [5]
 LDCM0316  AC53 HEK-293T C337(1.08); C352(1.02)  LDD1555  [5]
 LDCM0317  AC54 HEK-293T C337(1.08); C366(0.92)  LDD1556  [5]
 LDCM0318  AC55 HEK-293T C352(1.02)  LDD1557  [5]
 LDCM0319  AC56 HEK-293T C337(1.02)  LDD1558  [5]
 LDCM0320  AC57 HEK-293T C337(0.94); C352(1.11)  LDD1559  [5]
 LDCM0321  AC58 HEK-293T C310(0.97)  LDD1560  [5]
 LDCM0322  AC59 HEK-293T C352(0.93); C366(0.85)  LDD1561  [5]
 LDCM0323  AC6 HEK-293T C337(1.20); C366(0.92)  LDD1562  [5]
 LDCM0324  AC60 HEK-293T C337(1.19)  LDD1563  [5]
 LDCM0325  AC61 HEK-293T C337(1.12); C352(1.07)  LDD1564  [5]
 LDCM0326  AC62 HEK-293T C337(1.32); C366(0.93)  LDD1565  [5]
 LDCM0327  AC63 HEK-293T C352(1.00)  LDD1566  [5]
 LDCM0328  AC64 HEK-293T C337(0.91)  LDD1567  [5]
 LDCM0334  AC7 HEK-293T C352(0.99)  LDD1568  [5]
 LDCM0345  AC8 HEK-293T C337(0.94)  LDD1569  [5]
 LDCM0365  AC98 PaTu 8988t C84(0.95)  LDD1244  [4]
 LDCM0366  AC99 PaTu 8988t C84(1.41)  LDD1245  [4]
 LDCM0248  AKOS034007472 HEK-293T C337(1.04); C352(1.00)  LDD1511  [5]
 LDCM0356  AKOS034007680 HEK-293T C337(0.96); C352(1.08)  LDD1570  [5]
 LDCM0275  AKOS034007705 HEK-293T C337(0.77)  LDD1514  [5]
 LDCM0367  CL1 HEK-293T C310(1.19); C337(0.92)  LDD1571  [5]
 LDCM0368  CL10 HEK-293T C337(1.41); C366(1.24)  LDD1572  [5]
 LDCM0369  CL100 PaTu 8988t C84(0.30)  LDD1248  [4]
 LDCM0370  CL101 HEK-293T C310(0.99); C337(0.95)  LDD1574  [5]
 LDCM0371  CL102 HEK-293T C310(0.75)  LDD1575  [5]
 LDCM0372  CL103 HEK-293T C337(0.85); C352(1.03)  LDD1576  [5]
 LDCM0373  CL104 HEK-293T C310(0.74); C337(1.11); C352(1.02)  LDD1577  [5]
 LDCM0374  CL105 HEK-293T C310(1.12); C337(1.03)  LDD1578  [5]
 LDCM0375  CL106 HEK-293T C310(1.03)  LDD1579  [5]
 LDCM0376  CL107 HEK-293T C337(0.83); C352(0.94)  LDD1580  [5]
 LDCM0377  CL108 HEK-293T C310(1.17); C337(1.13); C352(0.95)  LDD1581  [5]
 LDCM0378  CL109 HEK-293T C310(1.20); C337(0.97)  LDD1582  [5]
 LDCM0379  CL11 HEK-293T C352(1.00)  LDD1583  [5]
 LDCM0380  CL110 HEK-293T C310(0.63)  LDD1584  [5]
 LDCM0381  CL111 HEK-293T C337(1.05); C352(1.09)  LDD1585  [5]
 LDCM0382  CL112 HEK-293T C310(0.72); C337(1.31); C352(0.99)  LDD1586  [5]
 LDCM0383  CL113 HEK-293T C310(0.93); C337(1.00)  LDD1587  [5]
 LDCM0384  CL114 HEK-293T C310(0.30)  LDD1588  [5]
 LDCM0385  CL115 HEK-293T C337(0.94); C352(1.00)  LDD1589  [5]
 LDCM0386  CL116 HEK-293T C310(0.92); C337(1.22); C352(0.99)  LDD1590  [5]
 LDCM0387  CL117 HEK-293T C310(0.90); C337(1.11)  LDD1591  [5]
 LDCM0388  CL118 HEK-293T C310(0.99)  LDD1592  [5]
 LDCM0389  CL119 HEK-293T C337(1.03); C352(1.01)  LDD1593  [5]
 LDCM0390  CL12 HEK-293T C337(0.79)  LDD1594  [5]
 LDCM0391  CL120 HEK-293T C310(0.88); C337(1.02); C352(1.03)  LDD1595  [5]
 LDCM0392  CL121 HEK-293T C310(1.07); C337(0.90)  LDD1596  [5]
 LDCM0393  CL122 HEK-293T C310(0.93)  LDD1597  [5]
 LDCM0394  CL123 HEK-293T C337(0.69); C352(1.28)  LDD1598  [5]
 LDCM0395  CL124 HEK-293T C310(0.76); C337(1.23); C352(1.06)  LDD1599  [5]
 LDCM0396  CL125 HEK-293T C310(0.90); C337(1.05)  LDD1600  [5]
 LDCM0397  CL126 HEK-293T C310(0.84)  LDD1601  [5]
 LDCM0398  CL127 HEK-293T C337(1.17); C352(1.03)  LDD1602  [5]
 LDCM0399  CL128 HEK-293T C310(0.84); C337(1.16); C352(1.01)  LDD1603  [5]
 LDCM0400  CL13 HEK-293T C310(1.12); C337(1.18)  LDD1604  [5]
 LDCM0401  CL14 HEK-293T C310(0.70)  LDD1605  [5]
 LDCM0402  CL15 HEK-293T C337(0.99); C352(1.45)  LDD1606  [5]
 LDCM0403  CL16 HEK-293T C310(0.90); C337(0.97); C352(0.96)  LDD1607  [5]
 LDCM0404  CL17 HEK-293T C337(0.89); C352(1.51)  LDD1608  [5]
 LDCM0405  CL18 HEK-293T C310(1.05)  LDD1609  [5]
 LDCM0406  CL19 HEK-293T C352(0.98); C366(0.91)  LDD1610  [5]
 LDCM0407  CL2 HEK-293T C310(0.97)  LDD1611  [5]
 LDCM0408  CL20 HEK-293T C337(0.94)  LDD1612  [5]
 LDCM0409  CL21 HEK-293T C337(1.06); C352(1.23)  LDD1613  [5]
 LDCM0410  CL22 HEK-293T C337(1.22); C366(1.23)  LDD1614  [5]
 LDCM0411  CL23 HEK-293T C352(1.03)  LDD1615  [5]
 LDCM0412  CL24 HEK-293T C337(0.81)  LDD1616  [5]
 LDCM0413  CL25 HEK-293T C310(0.78); C337(0.97)  LDD1617  [5]
 LDCM0414  CL26 HEK-293T C310(0.69)  LDD1618  [5]
 LDCM0415  CL27 HEK-293T C337(0.74); C352(1.00)  LDD1619  [5]
 LDCM0416  CL28 HEK-293T C310(0.71); C337(1.01); C352(0.99)  LDD1620  [5]
 LDCM0417  CL29 HEK-293T C337(0.99); C352(1.03)  LDD1621  [5]
 LDCM0418  CL3 HEK-293T C337(0.92); C352(1.08)  LDD1622  [5]
 LDCM0419  CL30 HEK-293T C310(1.03)  LDD1623  [5]
 LDCM0420  CL31 PaTu 8988t C84(0.89)  LDD1299  [4]
 LDCM0421  CL32 PaTu 8988t C84(0.76)  LDD1300  [4]
 LDCM0422  CL33 PaTu 8988t C84(0.88)  LDD1301  [4]
 LDCM0423  CL34 PaTu 8988t C84(0.78)  LDD1302  [4]
 LDCM0424  CL35 PaTu 8988t C84(0.65)  LDD1303  [4]
 LDCM0425  CL36 PaTu 8988t C84(0.25)  LDD1304  [4]
 LDCM0426  CL37 PaTu 8988t C84(0.77)  LDD1305  [4]
 LDCM0428  CL39 PaTu 8988t C84(0.70)  LDD1307  [4]
 LDCM0429  CL4 HEK-293T C310(1.08); C337(1.10); C352(1.02)  LDD1633  [5]
 LDCM0430  CL40 PaTu 8988t C84(0.71)  LDD1309  [4]
 LDCM0431  CL41 PaTu 8988t C84(0.76)  LDD1310  [4]
 LDCM0432  CL42 PaTu 8988t C84(0.93)  LDD1311  [4]
 LDCM0433  CL43 PaTu 8988t C84(0.86)  LDD1312  [4]
 LDCM0434  CL44 PaTu 8988t C84(0.67)  LDD1313  [4]
 LDCM0435  CL45 PaTu 8988t C84(0.70)  LDD1314  [4]
 LDCM0436  CL46 HEK-293T C337(1.02); C366(1.34)  LDD1640  [5]
 LDCM0437  CL47 HEK-293T C352(0.99)  LDD1641  [5]
 LDCM0438  CL48 HEK-293T C337(0.81)  LDD1642  [5]
 LDCM0439  CL49 HEK-293T C310(1.00); C337(0.94)  LDD1643  [5]
 LDCM0440  CL5 HEK-293T C337(1.12); C352(1.13)  LDD1644  [5]
 LDCM0441  CL50 HEK-293T C310(0.68)  LDD1645  [5]
 LDCM0443  CL52 HEK-293T C310(1.36); C337(1.21); C352(1.04)  LDD1646  [5]
 LDCM0444  CL53 HEK-293T C337(0.74); C352(1.23)  LDD1647  [5]
 LDCM0445  CL54 HEK-293T C310(1.06)  LDD1648  [5]
 LDCM0446  CL55 HEK-293T C352(0.95); C366(0.95)  LDD1649  [5]
 LDCM0447  CL56 HEK-293T C337(1.24)  LDD1650  [5]
 LDCM0448  CL57 HEK-293T C337(0.80); C352(1.43)  LDD1651  [5]
 LDCM0449  CL58 HEK-293T C337(1.07); C366(1.38)  LDD1652  [5]
 LDCM0450  CL59 HEK-293T C352(1.04)  LDD1653  [5]
 LDCM0451  CL6 HEK-293T C310(0.75)  LDD1654  [5]
 LDCM0452  CL60 HEK-293T C337(0.86)  LDD1655  [5]
 LDCM0453  CL61 HEK-293T C310(1.73); C337(1.02)  LDD1656  [5]
 LDCM0454  CL62 HEK-293T C310(0.93)  LDD1657  [5]
 LDCM0455  CL63 HEK-293T C337(0.96); C352(1.02)  LDD1658  [5]
 LDCM0456  CL64 HEK-293T C310(0.94); C337(1.41); C352(1.16)  LDD1659  [5]
 LDCM0457  CL65 HEK-293T C337(0.97); C352(1.11)  LDD1660  [5]
 LDCM0458  CL66 HEK-293T C310(0.95)  LDD1661  [5]
 LDCM0459  CL67 HEK-293T C352(0.94); C366(1.04)  LDD1662  [5]
 LDCM0460  CL68 HEK-293T C337(0.99)  LDD1663  [5]
 LDCM0461  CL69 HEK-293T C337(1.13); C352(1.08)  LDD1664  [5]
 LDCM0462  CL7 HEK-293T C352(0.97); C366(1.15)  LDD1665  [5]
 LDCM0463  CL70 HEK-293T C337(1.12); C366(1.17)  LDD1666  [5]
 LDCM0464  CL71 HEK-293T C352(1.01)  LDD1667  [5]
 LDCM0465  CL72 HEK-293T C337(0.81)  LDD1668  [5]
 LDCM0466  CL73 HEK-293T C310(0.92); C337(1.21)  LDD1669  [5]
 LDCM0467  CL74 HEK-293T C310(0.75)  LDD1670  [5]
 LDCM0469  CL76 PaTu 8988t C84(0.83)  LDD1348  [4]
 LDCM0470  CL77 PaTu 8988t C84(0.90)  LDD1349  [4]
 LDCM0471  CL78 PaTu 8988t C84(0.91)  LDD1350  [4]
 LDCM0472  CL79 PaTu 8988t C84(0.88)  LDD1351  [4]
 LDCM0473  CL8 HEK-293T C337(1.28)  LDD1676  [5]
 LDCM0474  CL80 PaTu 8988t C84(0.96)  LDD1353  [4]
 LDCM0475  CL81 PaTu 8988t C84(0.97)  LDD1354  [4]
 LDCM0476  CL82 PaTu 8988t C84(0.95)  LDD1355  [4]
 LDCM0477  CL83 PaTu 8988t C84(0.83)  LDD1356  [4]
 LDCM0478  CL84 PaTu 8988t C84(1.04)  LDD1357  [4]
 LDCM0479  CL85 PaTu 8988t C84(0.97)  LDD1358  [4]
 LDCM0480  CL86 PaTu 8988t C84(0.77)  LDD1359  [4]
 LDCM0481  CL87 PaTu 8988t C84(0.82)  LDD1360  [4]
 LDCM0482  CL88 PaTu 8988t C84(0.76)  LDD1361  [4]
 LDCM0483  CL89 PaTu 8988t C84(0.96)  LDD1362  [4]
 LDCM0484  CL9 HEK-293T C337(1.02); C352(1.03)  LDD1687  [5]
 LDCM0485  CL90 PaTu 8988t C84(0.83)  LDD1364  [4]
 LDCM0486  CL91 PaTu 8988t C84(0.23)  LDD1365  [4]
 LDCM0487  CL92 PaTu 8988t C84(0.29)  LDD1366  [4]
 LDCM0488  CL93 PaTu 8988t C84(0.19)  LDD1367  [4]
 LDCM0489  CL94 PaTu 8988t C84(0.29)  LDD1368  [4]
 LDCM0490  CL95 PaTu 8988t C84(0.37)  LDD1369  [4]
 LDCM0491  CL96 PaTu 8988t C84(0.32)  LDD1370  [4]
 LDCM0492  CL97 PaTu 8988t C84(0.21)  LDD1371  [4]
 LDCM0493  CL98 PaTu 8988t C84(0.24)  LDD1372  [4]
 LDCM0494  CL99 PaTu 8988t C84(0.28)  LDD1373  [4]
 LDCM0495  E2913 HEK-293T C337(1.00); C352(1.14)  LDD1698  [5]
 LDCM0468  Fragment33 HEK-293T C337(0.94); C352(1.04)  LDD1671  [5]
 LDCM0427  Fragment51 PaTu 8988t C84(0.96)  LDD1306  [4]
 LDCM0022  KB02 HEK-293T C337(0.94)  LDD1492  [5]
 LDCM0023  KB03 HEK-293T C337(0.98)  LDD1497  [5]
 LDCM0024  KB05 MIA PaCa-2 C352(2.72)  LDD3330  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Caspase-6 (CASP6) Peptidase C14A family P55212
Protein kinase C alpha type (PRKCA) AGC Ser/Thr protein kinase family P17252
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein gamma (YWHAG) 14-3-3 family P61981

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Lipoic Acid Small molecular drug DB00166

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402