Details of the Target

General Information of Target

Target ID LDTP13714
Target Name Histone-lysine N-methyltransferase SETD1B (SETD1B)
Gene Name SETD1B
Synonyms
KIAA1076; KMT2G; SET1B; Histone-lysine N-methyltransferase SETD1B; EC 2.1.1.364; Lysine N-methyltransferase 2G; SET domain-containing protein 1B; hSET1B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPLALVGVTLLLAAPPCSGAATPTPSLPPPPANDSDTSTGGCQGSYRCQPGVLLPVWEP
DDPSLGDKAARAVVYFVAMVYMFLGVSIIADRFMAAIEVITSKEKEITITKANGETSVGT
VRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFQAGELGPGTIVGSAAFNMFVVIAVC
IYVIPAGESRKIKHLRVFFVTASWSIFAYVWLYLILAVFSPGVVQVWEALLTLVFFPVCV
VFAWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKSIELDGTFVGAEAPGELGGLGP
GPAEARELDASRREVIQILKDLKQKHPDKDLEQLVGIANYYALLHQQKSRAFYRIQATRL
MTGAGNVLRRHAADASRRAAPAEGAGEDEDDGASRIFFEPSLYHCLENCGSVLLSVTCQG
GEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFV
RLLNLRVGDAQGMFEPDGGGRPKGRLVAPLLATVTILDDDHAGIFSFQDRLLHVSECMGT
VDVRVVRSSGARGTVRLPYRTVDGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEE
YEKKDNFFIELGQPQWLKRGISALLLNQGDGDRKLTAEEEEARRIAEMGKPVLGENCRLE
VIIEESYDFKNTVDKLIKKTNLALVIGTHSWREQFLEAITVSAGDEEEEEDGSREERLPS
CFDYVMHFLTVFWKVLFACVPPTEYCHGWACFGVSILVIGLLTALIGDLASHFGCTVGLK
DSVNAVVFVALGTSIPDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAAVY
WAVQGRPFEVRTGTLAFSVTLFTVFAFVGIAVLLYRRRPHIGGELGGPRGPKLATTALFL
GLWLLYILFASLEAYCHIRGF
Target Bioclass
Enzyme
Family
Class V-like SAM-binding methyltransferase superfamily
Subcellular location
Nucleus speckle
Function
Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place. Plays an essential role in regulating the transcriptional programming of multipotent hematopoietic progenitor cells and lymphoid lineage specification during hematopoiesis.
Uniprot ID
Q9UPS6
Ensemble ID
ENST00000542440.5
HGNC ID
HGNC:29187
ChEMBL ID
CHEMBL4105837

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
769P SNV: p.S1050L .
AN3CA Deletion: p.P749RfsTer7 .
CAL27 SNV: p.R1825W DBIA    Probe Info 
CALU1 Substitution: p.Q1589P .
CASKI SNV: p.E1128K .
COLO320 SNV: p.R982G .
DANG Substitution: p.Q1589P DBIA    Probe Info 
DU145 SNV: p.H1362R DBIA    Probe Info 
DU4475 SNV: p.Q1402R .
HCC44 SNV: p.E1118D .
HCT116 Insertion: p.S1055VfsTer50; p.R1623PfsTer5 .
HCT15 SNV: p.D159N; p.Q780H .
HEC1 SNV: p.P1415S .
HEC1B Deletion: p.P1361RfsTer38
Insertion: p.P694TfsTer148
SNV: p.P1415S		 .
HT115 SNV: p.S1782N .
JHH1 SNV: p.P592L .
KURAMOCHI SNV: p.G145R .
LN18 Substitution: p.Q1589P .
LS180 Deletion: p.Q1589SfsTer11 .
MCC13 Substitution: p.S1409F .
MKN1 SNV: p.P1594Q DBIA    Probe Info 
MOLT4 SNV: p.R1649L .
NCIH1793 SNV: p.E1353Ter DBIA    Probe Info 
NCIH2286 Substitution: p.E84Ter .
NCIH3122 Deletion: p.P694HfsTer30 .
NCIN87 Substitution: p.Q1589P .
NUGC3 SNV: p.A1657T; p.D1683G .
OVCAR5 SNV: p.R1491W DBIA    Probe Info 
OZ SNV: p.R1862L .
PF382 SNV: p.L872P .
RKO SNV: p.T1700A DBIA    Probe Info 
SBC5 Substitution: p.Q1589P DBIA    Probe Info 
SKMEL2 Deletion: p.L1255CfsTer20 DBIA    Probe Info 
TE1 Substitution: p.Q1589P DBIA    Probe Info 
TE10 SNV: p.P138H .
TOV21G SNV: p.E1078D .
WM793 SNV: p.M1? DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ONAyne
 Probe Info  		K508(6.25)  LDD0274  [1]
DBIA
 Probe Info  		C1698(5.06)  LDD3319  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [3]
NAIA_4
 Probe Info  		N.A.  LDD2226  [4]
IPM
 Probe Info  		N.A.  LDD0005  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C1918(2.90); C261(0.84)  LDD0812  [6]
 LDCM0215  AC10 HEK-293T C1911(0.88); C1918(0.89); C236(1.13); C261(1.13)  LDD0813  [6]
 LDCM0216  AC100 HEK-293T C1869(1.54); C1918(1.29); C236(1.27); C261(1.17)  LDD0814  [6]
 LDCM0217  AC101 HEK-293T C1869(1.40); C1918(1.00); C236(0.77); C261(0.84)  LDD0815  [6]
 LDCM0218  AC102 HEK-293T C1869(1.51); C1918(1.21); C236(0.97); C261(0.98)  LDD0816  [6]
 LDCM0219  AC103 HEK-293T C1869(1.32); C1918(1.29); C236(0.86); C261(0.93)  LDD0817  [6]
 LDCM0220  AC104 HEK-293T C1869(1.24); C1918(1.24); C236(1.17); C261(1.14)  LDD0818  [6]
 LDCM0221  AC105 HEK-293T C1869(1.48); C1918(1.03); C236(1.17); C261(1.00)  LDD0819  [6]
 LDCM0222  AC106 HEK-293T C1869(0.88); C1918(0.79); C236(1.16); C261(1.07)  LDD0820  [6]
 LDCM0223  AC107 HEK-293T C1869(1.32); C1918(1.09); C236(0.99); C261(1.09)  LDD0821  [6]
 LDCM0224  AC108 HEK-293T C1869(1.30); C1918(0.95); C236(0.72); C261(0.86)  LDD0822  [6]
 LDCM0225  AC109 HEK-293T C1869(1.23); C1918(0.98); C236(1.23); C261(1.08)  LDD0823  [6]
 LDCM0226  AC11 HEK-293T C1911(0.83); C1918(0.86); C236(1.00); C261(1.00)  LDD0824  [6]
 LDCM0227  AC110 HEK-293T C1869(2.16); C1918(1.58); C236(0.88); C261(1.07)  LDD0825  [6]
 LDCM0228  AC111 HEK-293T C1869(2.28); C1918(1.92); C236(1.26); C261(1.33)  LDD0826  [6]
 LDCM0229  AC112 HEK-293T C1869(2.85); C1918(1.74); C236(1.58); C261(1.38)  LDD0827  [6]
 LDCM0230  AC113 HEK-293T C1865(0.96); C1869(1.11); C236(1.66); C261(1.66)  LDD0828  [6]
 LDCM0231  AC114 HEK-293T C1865(1.38); C1869(2.35); C236(1.17); C261(1.17)  LDD0829  [6]
 LDCM0232  AC115 HEK-293T C1865(1.11); C1869(1.18); C236(1.16); C261(1.16)  LDD0830  [6]
 LDCM0233  AC116 HEK-293T C1865(1.35); C1869(1.30); C236(1.35); C261(1.35)  LDD0831  [6]
 LDCM0234  AC117 HEK-293T C1865(1.04); C1869(1.09); C236(1.15); C261(1.15)  LDD0832  [6]
 LDCM0235  AC118 HEK-293T C1865(1.28); C1869(1.66); C236(1.03); C261(1.03)  LDD0833  [6]
 LDCM0236  AC119 HEK-293T C1865(1.40); C1869(1.81); C236(1.31); C261(1.31)  LDD0834  [6]
 LDCM0237  AC12 HEK-293T C1911(0.90); C1918(0.89); C236(0.96); C261(0.96)  LDD0835  [6]
 LDCM0238  AC120 HEK-293T C1865(1.26); C1869(1.26); C236(1.09); C261(1.09)  LDD0836  [6]
 LDCM0239  AC121 HEK-293T C1865(1.47); C1869(1.26); C236(1.42); C261(1.42)  LDD0837  [6]
 LDCM0240  AC122 HEK-293T C1865(1.30); C1869(1.63); C236(1.26); C261(1.26)  LDD0838  [6]
 LDCM0241  AC123 HEK-293T C1865(1.59); C1869(1.42); C236(1.82); C261(1.82)  LDD0839  [6]
 LDCM0242  AC124 HEK-293T C1865(1.47); C1869(1.57); C236(1.72); C261(1.72)  LDD0840  [6]
 LDCM0243  AC125 HEK-293T C1865(1.31); C1869(1.41); C236(1.49); C261(1.49)  LDD0841  [6]
 LDCM0244  AC126 HEK-293T C1865(1.73); C1869(1.67); C236(1.45); C261(1.45)  LDD0842  [6]
 LDCM0245  AC127 HEK-293T C1865(2.47); C1869(2.97); C236(1.78); C261(1.78)  LDD0843  [6]
 LDCM0246  AC128 HEK-293T C1869(1.15); C236(1.44); C261(1.44)  LDD0844  [6]
 LDCM0247  AC129 HEK-293T C1869(1.52); C236(1.17); C261(1.17)  LDD0845  [6]
 LDCM0249  AC130 HEK-293T C1869(1.77); C236(1.45); C261(1.45)  LDD0847  [6]
 LDCM0250  AC131 HEK-293T C1869(1.32); C236(2.04); C261(2.04)  LDD0848  [6]
 LDCM0251  AC132 HEK-293T C1869(1.23); C236(1.37); C261(1.37)  LDD0849  [6]
 LDCM0252  AC133 HEK-293T C1869(1.68); C236(1.19); C261(1.19)  LDD0850  [6]
 LDCM0253  AC134 HEK-293T C1869(1.97); C236(1.39); C261(1.39)  LDD0851  [6]
 LDCM0254  AC135 HEK-293T C1869(1.18); C236(1.55); C261(1.55)  LDD0852  [6]
 LDCM0255  AC136 HEK-293T C1869(1.53); C236(1.03); C261(1.03)  LDD0853  [6]
 LDCM0256  AC137 HEK-293T C1869(1.31); C236(1.20); C261(1.20)  LDD0854  [6]
 LDCM0257  AC138 HEK-293T C1869(1.64); C236(1.32); C261(1.32)  LDD0855  [6]
 LDCM0258  AC139 HEK-293T C1869(1.58); C236(1.23); C261(1.23)  LDD0856  [6]
 LDCM0259  AC14 HEK-293T C1911(0.83); C1918(0.86); C236(0.94); C261(0.94)  LDD0857  [6]
 LDCM0260  AC140 HEK-293T C1869(1.20); C236(1.21); C261(1.21)  LDD0858  [6]
 LDCM0261  AC141 HEK-293T C1869(1.96); C236(1.03); C261(1.03)  LDD0859  [6]
 LDCM0262  AC142 HEK-293T C1869(1.92); C236(1.45); C261(1.45)  LDD0860  [6]
 LDCM0263  AC143 HEK-293T C1869(0.91); C1911(0.91)  LDD0861  [6]
 LDCM0264  AC144 HEK-293T C1869(1.46); C1911(0.90)  LDD0862  [6]
 LDCM0265  AC145 HEK-293T C1869(1.54); C1911(1.16)  LDD0863  [6]
 LDCM0266  AC146 HEK-293T C1869(1.52); C1911(0.95)  LDD0864  [6]
 LDCM0267  AC147 HEK-293T C1869(1.12); C1911(1.34)  LDD0865  [6]
 LDCM0268  AC148 HEK-293T C1869(1.21); C1911(0.86)  LDD0866  [6]
 LDCM0269  AC149 HEK-293T C1869(1.02); C1911(0.84)  LDD0867  [6]
 LDCM0270  AC15 HEK-293T C1911(0.87); C1918(0.99); C236(1.18); C261(1.18)  LDD0868  [6]
 LDCM0271  AC150 HEK-293T C1869(1.05); C1911(1.19)  LDD0869  [6]
 LDCM0272  AC151 HEK-293T C1869(1.03); C1911(1.35)  LDD0870  [6]
 LDCM0273  AC152 HEK-293T C1869(1.10); C1911(0.97)  LDD0871  [6]
 LDCM0274  AC153 HEK-293T C1869(1.03); C1911(1.21)  LDD0872  [6]
 LDCM0621  AC154 HEK-293T C1869(1.29); C1911(1.21)  LDD2162  [6]
 LDCM0622  AC155 HEK-293T C1869(1.34); C1911(1.17)  LDD2163  [6]
 LDCM0623  AC156 HEK-293T C1869(1.31); C1911(1.12)  LDD2164  [6]
 LDCM0624  AC157 HEK-293T C1869(2.16); C1911(1.73)  LDD2165  [6]
 LDCM0276  AC17 HEK-293T C1865(1.89); C1869(1.36); C1911(1.33); C1913(1.06)  LDD0874  [6]
 LDCM0277  AC18 HEK-293T C1865(1.30); C1869(0.99); C1911(1.54); C1913(1.62)  LDD0875  [6]
 LDCM0278  AC19 HEK-293T C1865(1.30); C1869(1.15); C1911(1.34); C1913(1.38)  LDD0876  [6]
 LDCM0279  AC2 HEK-293T C1918(1.03); C261(0.78)  LDD0877  [6]
 LDCM0280  AC20 HEK-293T C1865(1.87); C1869(1.36); C1911(1.44); C1913(1.24)  LDD0878  [6]
 LDCM0281  AC21 HEK-293T C1865(1.20); C1869(1.03); C1911(1.26); C1913(0.94)  LDD0879  [6]
 LDCM0282  AC22 HEK-293T C1865(1.50); C1869(1.40); C1911(1.10); C1913(1.10)  LDD0880  [6]
 LDCM0283  AC23 HEK-293T C1865(1.42); C1869(1.11); C1911(1.40); C1913(1.16)  LDD0881  [6]
 LDCM0284  AC24 HEK-293T C1865(1.33); C1869(1.24); C1911(1.27); C1913(1.18)  LDD0882  [6]
 LDCM0285  AC25 HEK-293T C1918(2.01); C236(0.53); C261(0.53)  LDD0883  [6]
 LDCM0286  AC26 HEK-293T C1918(1.67); C236(0.52); C261(0.52)  LDD0884  [6]
 LDCM0287  AC27 HEK-293T C1918(1.75); C236(0.66); C261(0.66)  LDD0885  [6]
 LDCM0288  AC28 HEK-293T C1918(1.23); C236(0.59); C261(0.59)  LDD0886  [6]
 LDCM0289  AC29 HEK-293T C1918(1.91); C236(0.66); C261(0.66)  LDD0887  [6]
 LDCM0290  AC3 HEK-293T C1918(0.97); C261(0.88)  LDD0888  [6]
 LDCM0291  AC30 HEK-293T C1918(1.85); C236(0.61); C261(0.61)  LDD0889  [6]
 LDCM0292  AC31 HEK-293T C1918(1.70); C236(0.67); C261(0.67)  LDD0890  [6]
 LDCM0293  AC32 HEK-293T C1918(1.89); C236(0.71); C261(0.71)  LDD0891  [6]
 LDCM0294  AC33 HEK-293T C1918(1.99); C236(0.60); C261(0.60)  LDD0892  [6]
 LDCM0295  AC34 HEK-293T C1918(1.96); C236(0.63); C261(0.63)  LDD0893  [6]
 LDCM0296  AC35 HEK-293T C1911(1.19); C1913(1.31); C1918(1.31)  LDD0894  [6]
 LDCM0297  AC36 HEK-293T C1911(1.10); C1913(1.23); C1918(1.23)  LDD0895  [6]
 LDCM0298  AC37 HEK-293T C1911(1.19); C1913(1.42); C1918(1.42)  LDD0896  [6]
 LDCM0299  AC38 HEK-293T C1911(1.26); C1913(1.29); C1918(1.29)  LDD0897  [6]
 LDCM0300  AC39 HEK-293T C1911(1.33); C1913(1.50); C1918(1.50)  LDD0898  [6]
 LDCM0301  AC4 HEK-293T C1918(0.97); C261(1.02)  LDD0899  [6]
 LDCM0302  AC40 HEK-293T C1911(1.19); C1913(1.24); C1918(1.24)  LDD0900  [6]
 LDCM0303  AC41 HEK-293T C1911(1.12); C1913(1.24); C1918(1.24)  LDD0901  [6]
 LDCM0304  AC42 HEK-293T C1911(1.10); C1913(1.37); C1918(1.37)  LDD0902  [6]
 LDCM0305  AC43 HEK-293T C1911(1.03); C1913(1.27); C1918(1.27)  LDD0903  [6]
 LDCM0306  AC44 HEK-293T C1911(1.02); C1913(1.14); C1918(1.14)  LDD0904  [6]
 LDCM0307  AC45 HEK-293T C1911(1.24); C1913(1.54); C1918(1.54)  LDD0905  [6]
 LDCM0308  AC46 HEK-293T C1865(0.99); C1869(0.76); C1911(1.08); C1913(0.88)  LDD0906  [6]
 LDCM0309  AC47 HEK-293T C1865(1.29); C1869(0.99); C1911(1.04); C1913(1.16)  LDD0907  [6]
 LDCM0310  AC48 HEK-293T C1865(1.28); C1869(0.91); C1911(1.07); C1913(1.12)  LDD0908  [6]
 LDCM0311  AC49 HEK-293T C1865(1.53); C1869(1.13); C1911(0.96); C1913(0.93)  LDD0909  [6]
 LDCM0312  AC5 HEK-293T C1918(1.08); C261(0.92)  LDD0910  [6]
 LDCM0313  AC50 HEK-293T C1865(1.26); C1869(0.99); C1911(0.99); C1913(1.23)  LDD0911  [6]
 LDCM0314  AC51 HEK-293T C1865(1.39); C1869(1.00); C1911(0.92); C1913(1.00)  LDD0912  [6]
 LDCM0315  AC52 HEK-293T C1865(1.77); C1869(1.13); C1911(1.02); C1913(0.89)  LDD0913  [6]
 LDCM0316  AC53 HEK-293T C1865(0.96); C1869(0.83); C1911(0.87); C1913(0.91)  LDD0914  [6]
 LDCM0317  AC54 HEK-293T C1865(1.36); C1869(1.06); C1911(0.98); C1913(0.89)  LDD0915  [6]
 LDCM0318  AC55 HEK-293T C1865(1.34); C1869(0.95); C1911(1.06); C1913(0.99)  LDD0916  [6]
 LDCM0319  AC56 HEK-293T C1865(1.38); C1869(1.17); C1911(0.93); C1913(0.89)  LDD0917  [6]
 LDCM0320  AC57 HEK-293T C1865(1.09); C1869(1.09); C1911(1.00); C236(1.08)  LDD0918  [6]
 LDCM0321  AC58 HEK-293T C1865(0.98); C1869(1.28); C1911(0.92); C236(0.83)  LDD0919  [6]
 LDCM0322  AC59 HEK-293T C1865(0.85); C1869(1.58); C1911(0.90); C236(0.57)  LDD0920  [6]
 LDCM0323  AC6 HEK-293T C1911(0.99); C1918(1.04); C236(0.91); C261(0.91)  LDD0921  [6]
 LDCM0324  AC60 HEK-293T C1865(1.25); C1869(1.04); C1911(0.78); C236(0.56)  LDD0922  [6]
 LDCM0325  AC61 HEK-293T C1865(1.03); C1869(1.07); C1911(1.02); C236(0.92)  LDD0923  [6]
 LDCM0326  AC62 HEK-293T C1865(0.91); C1869(1.35); C1911(1.05); C236(0.64)  LDD0924  [6]
 LDCM0327  AC63 HEK-293T C1865(0.96); C1869(1.10); C1911(0.98); C236(0.65)  LDD0925  [6]
 LDCM0328  AC64 HEK-293T C1865(1.01); C1869(1.28); C1911(0.93); C236(0.60)  LDD0926  [6]
 LDCM0329  AC65 HEK-293T C1865(0.99); C1869(1.07); C1911(1.16); C236(0.82)  LDD0927  [6]
 LDCM0330  AC66 HEK-293T C1865(0.90); C1869(1.18); C1911(0.79); C236(0.81)  LDD0928  [6]
 LDCM0331  AC67 HEK-293T C1865(1.10); C1869(1.21); C1911(0.82); C236(0.68)  LDD0929  [6]
 LDCM0332  AC68 HEK-293T C1865(0.99); C1869(0.93); C1911(0.99); C236(0.83)  LDD0930  [6]
 LDCM0333  AC69 HEK-293T C1865(1.07); C1869(1.04); C1911(1.27); C236(0.73)  LDD0931  [6]
 LDCM0334  AC7 HEK-293T C1911(0.96); C1918(0.96); C236(0.97); C261(0.97)  LDD0932  [6]
 LDCM0335  AC70 HEK-293T C1865(1.06); C1869(1.12); C1911(1.18); C236(0.54)  LDD0933  [6]
 LDCM0336  AC71 HEK-293T C1865(1.11); C1869(1.04); C1911(1.26); C236(0.61)  LDD0934  [6]
 LDCM0337  AC72 HEK-293T C1865(1.05); C1869(1.03); C1911(1.24); C236(0.72)  LDD0935  [6]
 LDCM0338  AC73 HEK-293T C1865(0.96); C1869(0.97); C1911(1.38); C236(0.69)  LDD0936  [6]
 LDCM0339  AC74 HEK-293T C1865(0.99); C1869(0.89); C1911(1.49); C236(0.71)  LDD0937  [6]
 LDCM0340  AC75 HEK-293T C1865(1.19); C1869(1.12); C1911(1.34); C236(1.05)  LDD0938  [6]
 LDCM0341  AC76 HEK-293T C1865(1.01); C1869(1.14); C1911(1.18); C236(1.22)  LDD0939  [6]
 LDCM0342  AC77 HEK-293T C1865(1.03); C1869(1.14); C1911(1.22); C236(0.73)  LDD0940  [6]
 LDCM0343  AC78 HEK-293T C1865(1.06); C1869(1.01); C1911(1.35); C236(0.98)  LDD0941  [6]
 LDCM0344  AC79 HEK-293T C1865(1.20); C1869(1.04); C1911(1.41); C236(1.32)  LDD0942  [6]
 LDCM0345  AC8 HEK-293T C1911(1.17); C1918(1.25); C236(0.81); C261(0.81)  LDD0943  [6]
 LDCM0346  AC80 HEK-293T C1865(1.16); C1869(1.28); C1911(1.33); C236(1.17)  LDD0944  [6]
 LDCM0347  AC81 HEK-293T C1865(1.01); C1869(1.07); C1911(1.44); C236(1.39)  LDD0945  [6]
 LDCM0348  AC82 HEK-293T C1865(1.49); C1869(1.56); C1911(1.78); C236(1.08)  LDD0946  [6]
 LDCM0349  AC83 HEK-293T C1865(1.14); C1869(1.14)  LDD0947  [6]
 LDCM0350  AC84 HEK-293T C1865(0.98); C1869(0.98)  LDD0948  [6]
 LDCM0351  AC85 HEK-293T C1865(1.15); C1869(1.15)  LDD0949  [6]
 LDCM0352  AC86 HEK-293T C1865(1.01); C1869(1.01)  LDD0950  [6]
 LDCM0353  AC87 HEK-293T C1865(0.90); C1869(0.90)  LDD0951  [6]
 LDCM0354  AC88 HEK-293T C1865(0.91); C1869(0.91)  LDD0952  [6]
 LDCM0355  AC89 HEK-293T C1865(1.12); C1869(1.12)  LDD0953  [6]
 LDCM0357  AC90 HEK-293T C1865(1.19); C1869(1.19)  LDD0955  [6]
 LDCM0358  AC91 HEK-293T C1865(1.17); C1869(1.17)  LDD0956  [6]
 LDCM0359  AC92 HEK-293T C1865(1.24); C1869(1.24)  LDD0957  [6]
 LDCM0360  AC93 HEK-293T C1865(1.24); C1869(1.24)  LDD0958  [6]
 LDCM0361  AC94 HEK-293T C1865(1.01); C1869(1.01)  LDD0959  [6]
 LDCM0362  AC95 HEK-293T C1865(1.02); C1869(1.02)  LDD0960  [6]
 LDCM0363  AC96 HEK-293T C1865(1.12); C1869(1.12)  LDD0961  [6]
 LDCM0364  AC97 HEK-293T C1865(1.95); C1869(1.95)  LDD0962  [6]
 LDCM0365  AC98 HEK-293T C1869(1.12); C1918(0.97); C236(1.06); C261(0.98)  LDD0963  [6]
 LDCM0366  AC99 HEK-293T C1869(1.35); C1918(0.78); C236(1.10); C261(1.10)  LDD0964  [6]
 LDCM0248  AKOS034007472 HEK-293T C1911(0.89); C1918(0.86); C236(1.03); C261(1.03)  LDD0846  [6]
 LDCM0356  AKOS034007680 HEK-293T C1911(0.95); C1918(1.06); C236(0.87); C261(0.87)  LDD0954  [6]
 LDCM0275  AKOS034007705 HEK-293T C1911(0.85); C1918(1.04); C236(1.11); C261(1.11)  LDD0873  [6]
 LDCM0630  CCW28-3 231MFP C1511(1.78)  LDD2214  [7]
 LDCM0367  CL1 HEK-293T C1865(1.36); C1869(1.29); C1918(1.49); C236(1.00)  LDD0965  [6]
 LDCM0368  CL10 HEK-293T C1865(1.98); C1869(1.96); C1918(2.61); C236(1.77)  LDD0966  [6]
 LDCM0369  CL100 HEK-293T C1918(1.32); C261(1.01)  LDD0967  [6]
 LDCM0370  CL101 HEK-293T C1911(0.94); C1918(1.35); C236(1.20); C261(1.20)  LDD0968  [6]
 LDCM0371  CL102 HEK-293T C1911(0.84); C1918(1.32); C236(1.91); C261(1.91)  LDD0969  [6]
 LDCM0372  CL103 HEK-293T C1911(1.09); C1918(1.18); C236(0.67); C261(0.67)  LDD0970  [6]
 LDCM0373  CL104 HEK-293T C1911(1.09); C1918(1.22); C236(1.00); C261(1.00)  LDD0971  [6]
 LDCM0374  CL105 HEK-293T C1865(1.70); C1869(1.39); C1911(1.65); C1913(1.98)  LDD0972  [6]
 LDCM0375  CL106 HEK-293T C1865(1.54); C1869(1.30); C1911(1.29); C1913(1.43)  LDD0973  [6]
 LDCM0376  CL107 HEK-293T C1865(1.02); C1869(0.95); C1911(1.33); C1913(1.24)  LDD0974  [6]
 LDCM0377  CL108 HEK-293T C1865(1.02); C1869(1.07); C1911(1.15); C1913(1.05)  LDD0975  [6]
 LDCM0378  CL109 HEK-293T C1865(1.20); C1869(1.28); C1911(1.20); C1913(1.21)  LDD0976  [6]
 LDCM0379  CL11 HEK-293T C1865(1.52); C1869(1.54); C1918(2.04); C236(0.98)  LDD0977  [6]
 LDCM0380  CL110 HEK-293T C1865(1.83); C1869(1.40); C1911(1.03); C1913(0.86)  LDD0978  [6]
 LDCM0381  CL111 HEK-293T C1865(1.60); C1869(1.22); C1911(0.95); C1913(0.85)  LDD0979  [6]
 LDCM0382  CL112 HEK-293T C1918(2.23); C236(0.84); C261(0.84)  LDD0980  [6]
 LDCM0383  CL113 HEK-293T C1918(1.56); C236(0.73); C261(0.73)  LDD0981  [6]
 LDCM0384  CL114 HEK-293T C1918(2.94); C236(0.69); C261(0.69)  LDD0982  [6]
 LDCM0385  CL115 HEK-293T C1918(2.18); C236(0.71); C261(0.71)  LDD0983  [6]
 LDCM0386  CL116 HEK-293T C1918(2.18); C236(0.66); C261(0.66)  LDD0984  [6]
 LDCM0387  CL117 HEK-293T C1911(1.28); C1913(1.50); C1918(1.50)  LDD0985  [6]
 LDCM0388  CL118 HEK-293T C1911(0.89); C1913(1.02); C1918(1.02)  LDD0986  [6]
 LDCM0389  CL119 HEK-293T C1911(1.03); C1913(1.03); C1918(1.03)  LDD0987  [6]
 LDCM0390  CL12 HEK-293T C1865(0.95); C1869(0.96); C1918(1.17); C236(0.97)  LDD0988  [6]
 LDCM0391  CL120 HEK-293T C1911(1.04); C1913(1.31); C1918(1.31)  LDD0989  [6]
 LDCM0392  CL121 HEK-293T C1865(1.57); C1869(1.17); C1911(1.16); C1913(0.97)  LDD0990  [6]
 LDCM0393  CL122 HEK-293T C1865(1.09); C1869(0.93); C1911(0.94); C1913(0.95)  LDD0991  [6]
 LDCM0394  CL123 HEK-293T C1865(1.07); C1869(0.86); C1911(1.01); C1913(1.16)  LDD0992  [6]
 LDCM0395  CL124 HEK-293T C1865(1.34); C1869(0.96); C1911(0.97); C1913(0.88)  LDD0993  [6]
 LDCM0396  CL125 HEK-293T C1865(0.86); C1869(1.46); C1911(0.92); C236(1.17)  LDD0994  [6]
 LDCM0397  CL126 HEK-293T C1865(0.76); C1869(1.13); C1911(0.94); C236(0.62)  LDD0995  [6]
 LDCM0398  CL127 HEK-293T C1865(0.77); C1869(0.91); C1911(1.07); C236(0.65)  LDD0996  [6]
 LDCM0399  CL128 HEK-293T C1865(1.12); C1869(1.32); C1911(0.95); C236(0.64)  LDD0997  [6]
 LDCM0400  CL13 HEK-293T C1865(1.01); C1869(1.07); C1918(1.10); C236(0.70)  LDD0998  [6]
 LDCM0401  CL14 HEK-293T C1865(1.17); C1869(1.03); C1918(1.35); C236(1.50)  LDD0999  [6]
 LDCM0402  CL15 HEK-293T C1865(1.25); C1869(1.10); C1918(2.48); C236(1.54)  LDD1000  [6]
 LDCM0403  CL16 HEK-293T C1865(1.55); C1869(1.55); C1911(0.88); C1918(1.29)  LDD1001  [6]
 LDCM0404  CL17 HEK-293T C1865(1.49); C1869(1.49); C1911(0.83); C1918(1.75)  LDD1002  [6]
 LDCM0405  CL18 HEK-293T C1865(1.47); C1869(1.47); C1911(1.09); C1918(1.97)  LDD1003  [6]
 LDCM0406  CL19 HEK-293T C1865(1.16); C1869(1.16); C1911(0.90); C1918(1.23)  LDD1004  [6]
 LDCM0407  CL2 HEK-293T C1865(1.37); C1869(1.20); C1918(1.20); C236(0.94)  LDD1005  [6]
 LDCM0408  CL20 HEK-293T C1865(1.39); C1869(1.39); C1911(0.92); C1918(1.34)  LDD1006  [6]
 LDCM0409  CL21 HEK-293T C1865(1.19); C1869(1.19); C1911(1.00); C1918(1.56)  LDD1007  [6]
 LDCM0410  CL22 HEK-293T C1865(1.33); C1869(1.33); C1911(1.10); C1918(1.77)  LDD1008  [6]
 LDCM0411  CL23 HEK-293T C1865(1.18); C1869(1.18); C1911(0.85); C1918(1.30)  LDD1009  [6]
 LDCM0412  CL24 HEK-293T C1865(1.23); C1869(1.23); C1911(1.05); C1918(1.38)  LDD1010  [6]
 LDCM0413  CL25 HEK-293T C1865(1.35); C1869(1.35); C1911(1.06); C1918(2.14)  LDD1011  [6]
 LDCM0414  CL26 HEK-293T C1865(1.25); C1869(1.25); C1911(1.12); C1918(1.13)  LDD1012  [6]
 LDCM0415  CL27 HEK-293T C1865(0.98); C1869(0.98); C1911(1.00); C1918(1.01)  LDD1013  [6]
 LDCM0416  CL28 HEK-293T C1865(0.94); C1869(0.94); C1911(0.83); C1918(1.11)  LDD1014  [6]
 LDCM0417  CL29 HEK-293T C1865(1.05); C1869(1.05); C1911(0.97); C1918(1.90)  LDD1015  [6]
 LDCM0418  CL3 HEK-293T C1865(1.48); C1869(1.30); C1918(1.40); C236(0.82)  LDD1016  [6]
 LDCM0419  CL30 HEK-293T C1865(1.40); C1869(1.40); C1911(1.08); C1918(1.53)  LDD1017  [6]
 LDCM0420  CL31 HEK-293T C1865(1.73); C1869(1.41); C1911(0.86); C1913(0.95)  LDD1018  [6]
 LDCM0421  CL32 HEK-293T C1865(1.81); C1869(1.46); C1911(1.00); C1913(0.89)  LDD1019  [6]
 LDCM0422  CL33 HEK-293T C1865(1.56); C1869(1.34); C1911(0.82); C1913(0.80)  LDD1020  [6]
 LDCM0423  CL34 HEK-293T C1865(1.53); C1869(1.32); C1911(1.01); C1913(1.11)  LDD1021  [6]
 LDCM0424  CL35 HEK-293T C1865(1.63); C1869(1.46); C1911(1.19); C1913(0.94)  LDD1022  [6]
 LDCM0425  CL36 HEK-293T C1865(0.92); C1869(0.95); C1911(1.00); C1913(0.81)  LDD1023  [6]
 LDCM0426  CL37 HEK-293T C1865(1.68); C1869(1.33); C1911(0.87); C1913(0.82)  LDD1024  [6]
 LDCM0428  CL39 HEK-293T C1865(2.72); C1869(2.04); C1911(0.96); C1913(0.80)  LDD1026  [6]
 LDCM0429  CL4 HEK-293T C1865(1.06); C1869(1.03); C1918(1.38); C236(1.22)  LDD1027  [6]
 LDCM0430  CL40 HEK-293T C1865(1.17); C1869(1.11); C1911(1.05); C1913(0.90)  LDD1028  [6]
 LDCM0431  CL41 HEK-293T C1865(1.38); C1869(1.35); C1911(1.02); C1913(0.80)  LDD1029  [6]
 LDCM0432  CL42 HEK-293T C1865(1.61); C1869(1.44); C1911(1.04); C1913(0.80)  LDD1030  [6]
 LDCM0433  CL43 HEK-293T C1865(1.72); C1869(1.46); C1911(0.97); C1913(0.80)  LDD1031  [6]
 LDCM0434  CL44 HEK-293T C1865(1.56); C1869(1.39); C1911(0.90); C1913(0.83)  LDD1032  [6]
 LDCM0435  CL45 HEK-293T C1865(1.64); C1869(1.46); C1911(0.84); C1913(0.82)  LDD1033  [6]
 LDCM0436  CL46 HEK-293T C1865(1.68); C1869(1.68); C1911(1.07); C236(1.04)  LDD1034  [6]
 LDCM0437  CL47 HEK-293T C1865(1.16); C1869(1.16); C1911(1.30); C236(0.92)  LDD1035  [6]
 LDCM0438  CL48 HEK-293T C1865(1.44); C1869(1.44); C1911(1.10); C236(0.77)  LDD1036  [6]
 LDCM0439  CL49 HEK-293T C1865(1.26); C1869(1.26); C1911(1.14); C236(0.91)  LDD1037  [6]
 LDCM0440  CL5 HEK-293T C1865(1.20); C1869(1.24); C1918(1.18); C236(0.80)  LDD1038  [6]
 LDCM0441  CL50 HEK-293T C1865(1.59); C1869(1.59); C1911(1.26); C236(1.17)  LDD1039  [6]
 LDCM0442  CL51 HEK-293T C1865(1.17); C1869(1.17); C1911(1.31); C236(1.55)  LDD1040  [6]
 LDCM0443  CL52 HEK-293T C1865(1.05); C1869(1.05); C1911(0.83); C236(1.70)  LDD1041  [6]
 LDCM0444  CL53 HEK-293T C1865(1.14); C1869(1.14); C1911(0.97); C236(1.06)  LDD1042  [6]
 LDCM0445  CL54 HEK-293T C1865(1.08); C1869(1.08); C1911(1.12); C236(1.17)  LDD1043  [6]
 LDCM0446  CL55 HEK-293T C1865(1.40); C1869(1.40); C1911(1.34); C236(1.05)  LDD1044  [6]
 LDCM0447  CL56 HEK-293T C1865(1.23); C1869(1.23); C1911(0.93); C236(0.67)  LDD1045  [6]
 LDCM0448  CL57 HEK-293T C1865(1.29); C1869(1.29); C1911(0.91); C236(1.10)  LDD1046  [6]
 LDCM0449  CL58 HEK-293T C1865(1.07); C1869(1.07); C1911(1.24); C236(1.54)  LDD1047  [6]
 LDCM0450  CL59 HEK-293T C1865(1.37); C1869(1.37); C1911(1.34); C236(0.96)  LDD1048  [6]
 LDCM0451  CL6 HEK-293T C1865(1.08); C1869(1.02); C1918(1.35); C236(1.23)  LDD1049  [6]
 LDCM0452  CL60 HEK-293T C1865(1.57); C1869(1.57); C1911(1.50); C236(1.16)  LDD1050  [6]
 LDCM0453  CL61 HEK-293T C1869(0.95); C1911(1.20); C1918(1.13)  LDD1051  [6]
 LDCM0454  CL62 HEK-293T C1869(1.34); C1911(0.86); C1918(1.44)  LDD1052  [6]
 LDCM0455  CL63 HEK-293T C1869(1.32); C1911(0.83); C1918(1.71)  LDD1053  [6]
 LDCM0456  CL64 HEK-293T C1869(1.07); C1911(0.79); C1918(1.70)  LDD1054  [6]
 LDCM0457  CL65 HEK-293T C1869(1.32); C1911(0.94); C1918(1.22)  LDD1055  [6]
 LDCM0458  CL66 HEK-293T C1869(1.08); C1911(0.81); C1918(1.32)  LDD1056  [6]
 LDCM0459  CL67 HEK-293T C1869(1.05); C1911(0.83); C1918(1.26)  LDD1057  [6]
 LDCM0460  CL68 HEK-293T C1869(0.90); C1911(0.81); C1918(1.19)  LDD1058  [6]
 LDCM0461  CL69 HEK-293T C1869(0.93); C1911(0.82); C1918(1.27)  LDD1059  [6]
 LDCM0462  CL7 HEK-293T C1865(1.40); C1869(1.16); C1918(1.45); C236(0.77)  LDD1060  [6]
 LDCM0463  CL70 HEK-293T C1869(1.15); C1911(0.98); C1918(1.12)  LDD1061  [6]
 LDCM0464  CL71 HEK-293T C1869(0.85); C1911(0.79); C1918(1.46)  LDD1062  [6]
 LDCM0465  CL72 HEK-293T C1869(0.97); C1911(1.14); C1918(1.16)  LDD1063  [6]
 LDCM0466  CL73 HEK-293T C1869(0.88); C1911(0.98); C1918(1.55)  LDD1064  [6]
 LDCM0467  CL74 HEK-293T C1869(1.61); C1911(1.16); C1918(1.90)  LDD1065  [6]
 LDCM0469  CL76 HEK-293T C1865(1.12); C1869(1.12); C1911(1.03); C1913(1.07)  LDD1067  [6]
 LDCM0470  CL77 HEK-293T C1865(1.23); C1869(1.23); C1911(1.04); C1913(1.05)  LDD1068  [6]
 LDCM0471  CL78 HEK-293T C1865(1.79); C1869(1.79); C1911(0.83); C1913(0.96)  LDD1069  [6]
 LDCM0472  CL79 HEK-293T C1865(1.46); C1869(1.46); C1911(0.89); C1913(0.86)  LDD1070  [6]
 LDCM0473  CL8 HEK-293T C1865(2.03); C1869(0.78); C236(1.30); C261(0.71)  LDD1071  [6]
 LDCM0474  CL80 HEK-293T C1865(1.28); C1869(1.28); C1911(0.90); C1913(0.94)  LDD1072  [6]
 LDCM0475  CL81 HEK-293T C1865(1.24); C1869(1.24); C1911(1.03); C1913(1.09)  LDD1073  [6]
 LDCM0476  CL82 HEK-293T C1865(0.81); C1869(0.81); C1911(1.13); C1913(1.00)  LDD1074  [6]
 LDCM0477  CL83 HEK-293T C1865(0.78); C1869(0.78); C1911(1.03); C1913(0.86)  LDD1075  [6]
 LDCM0478  CL84 HEK-293T C1865(1.30); C1869(1.30); C1911(0.92); C1913(1.03)  LDD1076  [6]
 LDCM0479  CL85 HEK-293T C1865(1.40); C1869(1.40); C1911(0.86); C1913(1.05)  LDD1077  [6]
 LDCM0480  CL86 HEK-293T C1865(1.72); C1869(1.72); C1911(0.93); C1913(1.15)  LDD1078  [6]
 LDCM0481  CL87 HEK-293T C1865(1.42); C1869(1.42); C1911(1.06); C1913(1.23)  LDD1079  [6]
 LDCM0482  CL88 HEK-293T C1865(1.09); C1869(1.09); C1911(1.12); C1913(1.24)  LDD1080  [6]
 LDCM0483  CL89 HEK-293T C1865(1.21); C1869(1.21); C1911(0.97); C1913(1.11)  LDD1081  [6]
 LDCM0484  CL9 HEK-293T C1865(1.02); C1869(0.79); C236(1.41); C261(0.82)  LDD1082  [6]
 LDCM0485  CL90 HEK-293T C1865(1.04); C1869(1.04); C1911(1.03); C1913(1.12)  LDD1083  [6]
 LDCM0486  CL91 HEK-293T C1918(1.32); C261(0.86)  LDD1084  [6]
 LDCM0487  CL92 HEK-293T C1918(1.51); C261(1.07)  LDD1085  [6]
 LDCM0488  CL93 HEK-293T C1918(1.41); C261(0.94)  LDD1086  [6]
 LDCM0489  CL94 HEK-293T C1918(1.92); C261(0.91)  LDD1087  [6]
 LDCM0490  CL95 HEK-293T C1918(3.14); C261(0.83)  LDD1088  [6]
 LDCM0491  CL96 HEK-293T C1918(1.54); C261(0.98)  LDD1089  [6]
 LDCM0492  CL97 HEK-293T C1918(1.33); C261(0.75)  LDD1090  [6]
 LDCM0493  CL98 HEK-293T C1918(1.34); C261(0.97)  LDD1091  [6]
 LDCM0494  CL99 HEK-293T C1918(1.22); C261(0.91)  LDD1092  [6]
 LDCM0495  E2913 HEK-293T C931(1.26); C1448(0.74); C1908(1.03)  LDD1698  [8]
 LDCM0468  Fragment33 HEK-293T C1869(1.39); C1911(1.17); C1918(2.13)  LDD1066  [6]
 LDCM0427  Fragment51 HEK-293T C1865(1.13); C1869(1.16); C1911(0.80); C1913(0.82)  LDD1025  [6]
 LDCM0022  KB02 HEK-293T C1698(0.96); C1448(0.98); C1908(1.03)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C1698(1.12); C1448(0.85); C1908(1.06)  LDD1497  [8]
 LDCM0024  KB05 MEWO C1698(5.06)  LDD3319  [2]

References

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Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402