Details of the Target

General Information of Target

Target ID LDTP13483
Target Name F-box/LRR-repeat protein 3 (FBXL3)
Gene Name FBXL3
Gene ID 26224
Synonyms
FBL3A; FBXL3A; F-box/LRR-repeat protein 3; F-box and leucine-rich repeat protein 3A; F-box/LRR-repeat protein 3A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGSEPRSGTNSPPPPFSDWGRLEAAILSGWKTFWQSVSKERVARTTSREEVDEAASTLT
RLPIDVQLYILSFLSPHDLCQLGSTNHYWNETVRDPILWRYFLLRDLPSWSSVDWKSLPD
LEILKKPISEVTDGAFFDYMAVYRMCCPYTRRASKSSRPMYGAVTSFLHSLIIQNEPRFA
MFGPGLEELNTSLVLSLMSSEELCPTAGLPQRQIDGIGSGVNFQLNNQHKFNILILYSTT
RKERDRAREEHTSAVNKMFSRHNEGDDQQGSRYSVIPQIQKVCEVVDGFIYVANAEAHKR
HEWQDEFSHIMAMTDPAFGSSGRPLLVLSCISQGDVKRMPCFYLAHELHLNLLNHPWLVQ
DTEAETLTGFLNGIEWILEEVESKRAR
Target Bioclass
Enzyme
Subcellular location
Nucleus
Function
Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2. Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex.
Uniprot ID
Q9UKT7
Ensemble ID
ENST00000355619.10
HGNC ID
HGNC:13599

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
BTD
 Probe Info  		C63(0.86)  LDD2123  [2]
DBIA
 Probe Info  		C128(1.17); C137(1.17)  LDD0532  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [4]
AOyne
 Probe Info  		15.00  LDD0443  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C63(1.12)  LDD2152  [2]
 LDCM0214  AC1 HEK-293T C128(0.91); C137(1.03)  LDD0812  [3]
 LDCM0215  AC10 HCT 116 C128(1.17); C137(1.17)  LDD0532  [3]
 LDCM0216  AC100 HEK-293T C137(0.85)  LDD0814  [3]
 LDCM0217  AC101 HEK-293T C137(1.10)  LDD0815  [3]
 LDCM0218  AC102 HEK-293T C137(0.93)  LDD0816  [3]
 LDCM0219  AC103 HEK-293T C137(0.90)  LDD0817  [3]
 LDCM0220  AC104 HEK-293T C137(0.92)  LDD0818  [3]
 LDCM0221  AC105 HEK-293T C137(1.17)  LDD0819  [3]
 LDCM0222  AC106 HEK-293T C137(1.10)  LDD0820  [3]
 LDCM0223  AC107 HEK-293T C137(0.85)  LDD0821  [3]
 LDCM0224  AC108 HEK-293T C137(0.96)  LDD0822  [3]
 LDCM0225  AC109 HEK-293T C137(0.92)  LDD0823  [3]
 LDCM0226  AC11 HCT 116 C128(1.11); C137(1.11)  LDD0543  [3]
 LDCM0227  AC110 HEK-293T C137(0.82)  LDD0825  [3]
 LDCM0228  AC111 HEK-293T C137(0.52)  LDD0826  [3]
 LDCM0229  AC112 HEK-293T C137(0.77)  LDD0827  [3]
 LDCM0230  AC113 HEK-293T C128(1.03); C137(1.19)  LDD0828  [3]
 LDCM0231  AC114 HEK-293T C128(0.98); C137(0.90)  LDD0829  [3]
 LDCM0232  AC115 HEK-293T C128(1.00); C137(0.75)  LDD0830  [3]
 LDCM0233  AC116 HEK-293T C128(0.91); C137(0.91)  LDD0831  [3]
 LDCM0234  AC117 HEK-293T C128(0.89); C137(0.63)  LDD0832  [3]
 LDCM0235  AC118 HEK-293T C128(0.85); C137(0.71)  LDD0833  [3]
 LDCM0236  AC119 HEK-293T C128(0.88); C137(0.75)  LDD0834  [3]
 LDCM0237  AC12 HCT 116 C128(0.98); C137(0.98)  LDD0554  [3]
 LDCM0238  AC120 HEK-293T C128(0.90); C137(0.69)  LDD0836  [3]
 LDCM0239  AC121 HEK-293T C128(0.80); C137(0.48)  LDD0837  [3]
 LDCM0240  AC122 HEK-293T C128(0.87); C137(0.60)  LDD0838  [3]
 LDCM0241  AC123 HEK-293T C128(0.81); C137(0.65)  LDD0839  [3]
 LDCM0242  AC124 HEK-293T C128(0.84); C137(0.66)  LDD0840  [3]
 LDCM0243  AC125 HEK-293T C128(0.84); C137(0.64)  LDD0841  [3]
 LDCM0244  AC126 HEK-293T C128(0.79); C137(0.65)  LDD0842  [3]
 LDCM0245  AC127 HEK-293T C128(0.67); C137(0.42)  LDD0843  [3]
 LDCM0246  AC128 HEK-293T C128(1.01)  LDD0844  [3]
 LDCM0247  AC129 HEK-293T C128(0.98)  LDD0845  [3]
 LDCM0249  AC130 HEK-293T C128(0.90)  LDD0847  [3]
 LDCM0250  AC131 HEK-293T C128(0.96)  LDD0848  [3]
 LDCM0251  AC132 HEK-293T C128(0.94)  LDD0849  [3]
 LDCM0252  AC133 HEK-293T C128(0.94)  LDD0850  [3]
 LDCM0253  AC134 HEK-293T C128(1.01)  LDD0851  [3]
 LDCM0254  AC135 HEK-293T C128(0.78)  LDD0852  [3]
 LDCM0255  AC136 HEK-293T C128(0.71)  LDD0853  [3]
 LDCM0256  AC137 HEK-293T C128(0.87)  LDD0854  [3]
 LDCM0257  AC138 HEK-293T C128(0.88)  LDD0855  [3]
 LDCM0258  AC139 HEK-293T C128(0.81)  LDD0856  [3]
 LDCM0259  AC14 HCT 116 C128(1.15); C137(1.15)  LDD0576  [3]
 LDCM0260  AC140 HEK-293T C128(0.86)  LDD0858  [3]
 LDCM0261  AC141 HEK-293T C128(0.89)  LDD0859  [3]
 LDCM0262  AC142 HEK-293T C128(0.92)  LDD0860  [3]
 LDCM0270  AC15 HCT 116 C128(1.10); C137(1.10)  LDD0587  [3]
 LDCM0276  AC17 HCT 116 C128(1.07); C137(1.07)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C128(1.99); C137(1.99)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C128(1.14); C137(1.14)  LDD0595  [3]
 LDCM0279  AC2 HEK-293T C128(0.80); C137(0.92)  LDD0877  [3]
 LDCM0280  AC20 HCT 116 C128(1.03); C137(1.03)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C128(1.02); C137(1.02)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C128(1.04); C137(1.04)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C128(1.08); C137(1.08)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C128(1.02); C137(1.02)  LDD0601  [3]
 LDCM0285  AC25 PaTu 8988t C369(1.00); C373(1.00); C128(1.00); C137(1.00)  LDD1164  [3]
 LDCM0286  AC26 PaTu 8988t C369(1.09); C373(1.09); C128(0.92); C137(0.92)  LDD1165  [3]
 LDCM0287  AC27 PaTu 8988t C369(1.02); C373(1.02); C128(1.00); C137(1.00)  LDD1166  [3]
 LDCM0288  AC28 PaTu 8988t C369(1.07); C373(1.07); C128(1.02); C137(1.02)  LDD1167  [3]
 LDCM0289  AC29 PaTu 8988t C369(1.11); C373(1.11); C128(1.04); C137(1.04)  LDD1168  [3]
 LDCM0290  AC3 HEK-293T C128(0.86); C137(0.97)  LDD0888  [3]
 LDCM0291  AC30 PaTu 8988t C369(1.03); C373(1.03); C128(1.24); C137(1.24)  LDD1170  [3]
 LDCM0292  AC31 PaTu 8988t C369(0.89); C373(0.89); C128(1.03); C137(1.03)  LDD1171  [3]
 LDCM0293  AC32 PaTu 8988t C369(1.12); C373(1.12); C128(1.05); C137(1.05)  LDD1172  [3]
 LDCM0294  AC33 PaTu 8988t C369(1.15); C373(1.15); C128(1.03); C137(1.03)  LDD1173  [3]
 LDCM0295  AC34 PaTu 8988t C369(1.17); C373(1.17); C128(1.06); C137(1.06)  LDD1174  [3]
 LDCM0296  AC35 HCT 116 C128(1.06); C137(1.06)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C128(1.00); C137(1.00)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C128(0.92); C137(0.92)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C128(1.01); C137(1.01)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C128(1.00); C137(1.00)  LDD0617  [3]
 LDCM0301  AC4 HEK-293T C128(0.91); C137(0.98)  LDD0899  [3]
 LDCM0302  AC40 HCT 116 C128(1.24); C137(1.24)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C128(0.89); C137(0.89)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C128(0.97); C137(0.97)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C128(1.09); C137(1.09)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C128(1.14); C137(1.14)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C128(1.10); C137(1.10)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C128(0.96); C137(0.96)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C128(0.98); C137(0.98)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C128(0.94); C137(0.94)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C128(1.16); C137(1.16)  LDD0628  [3]
 LDCM0312  AC5 HEK-293T C128(0.89); C137(1.04)  LDD0910  [3]
 LDCM0313  AC50 HCT 116 C128(1.09); C137(1.09)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C128(0.90); C137(0.90)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C128(0.93); C137(0.93)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C128(1.11); C137(1.11)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C128(1.04); C137(1.04)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C128(1.20); C137(1.20)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C128(1.48); C137(1.48)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C128(1.06); C137(1.06)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C128(1.04); C137(1.04)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C128(1.30); C137(1.30)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C128(1.13); C137(1.13)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C128(0.89); C137(0.89)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C128(0.77); C137(0.77)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C128(1.00); C137(1.00)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C128(1.03); C137(1.03)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C128(0.97); C137(0.97)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C128(1.18); C137(1.18)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C128(1.09); C137(1.09)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C128(0.84); C137(0.84)  LDD0648  [3]
 LDCM0332  AC68 HEK-293T C137(1.02)  LDD0930  [3]
 LDCM0333  AC69 HEK-293T C137(1.10)  LDD0931  [3]
 LDCM0334  AC7 HCT 116 C128(1.08); C137(1.08)  LDD0651  [3]
 LDCM0335  AC70 HEK-293T C137(1.01)  LDD0933  [3]
 LDCM0336  AC71 HEK-293T C137(0.99)  LDD0934  [3]
 LDCM0337  AC72 HEK-293T C137(1.00)  LDD0935  [3]
 LDCM0338  AC73 HEK-293T C137(0.90)  LDD0936  [3]
 LDCM0339  AC74 HEK-293T C137(1.04)  LDD0937  [3]
 LDCM0340  AC75 HEK-293T C137(1.07)  LDD0938  [3]
 LDCM0341  AC76 HEK-293T C137(1.03)  LDD0939  [3]
 LDCM0342  AC77 HEK-293T C137(1.08)  LDD0940  [3]
 LDCM0343  AC78 HEK-293T C137(1.05)  LDD0941  [3]
 LDCM0344  AC79 HEK-293T C137(1.11)  LDD0942  [3]
 LDCM0345  AC8 HCT 116 C128(1.05); C137(1.05)  LDD0662  [3]
 LDCM0346  AC80 HEK-293T C137(0.88)  LDD0944  [3]
 LDCM0347  AC81 HEK-293T C137(1.02)  LDD0945  [3]
 LDCM0348  AC82 HEK-293T C137(0.87)  LDD0946  [3]
 LDCM0349  AC83 HEK-293T C128(1.02); C137(0.81)  LDD0947  [3]
 LDCM0350  AC84 HEK-293T C128(0.82); C137(0.69)  LDD0948  [3]
 LDCM0351  AC85 HEK-293T C128(0.96); C137(0.66)  LDD0949  [3]
 LDCM0352  AC86 HEK-293T C128(0.96); C137(0.65)  LDD0950  [3]
 LDCM0353  AC87 HEK-293T C128(0.87); C137(0.69)  LDD0951  [3]
 LDCM0354  AC88 HEK-293T C128(0.92); C137(0.68)  LDD0952  [3]
 LDCM0355  AC89 HEK-293T C128(0.82); C137(0.68)  LDD0953  [3]
 LDCM0357  AC90 HEK-293T C128(0.82); C137(0.62)  LDD0955  [3]
 LDCM0358  AC91 HEK-293T C128(0.82); C137(1.03)  LDD0956  [3]
 LDCM0359  AC92 HEK-293T C128(0.98); C137(0.83)  LDD0957  [3]
 LDCM0360  AC93 HEK-293T C128(0.76); C137(0.47)  LDD0958  [3]
 LDCM0361  AC94 HEK-293T C128(0.81); C137(0.59)  LDD0959  [3]
 LDCM0362  AC95 HEK-293T C128(0.90); C137(0.77)  LDD0960  [3]
 LDCM0363  AC96 HEK-293T C128(0.57); C137(0.55)  LDD0961  [3]
 LDCM0364  AC97 HEK-293T C128(0.74); C137(0.49)  LDD0962  [3]
 LDCM0365  AC98 HEK-293T C137(0.94)  LDD0963  [3]
 LDCM0366  AC99 HEK-293T C137(0.97)  LDD0964  [3]
 LDCM0248  AKOS034007472 HCT 116 C128(1.12); C137(1.12)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C128(1.10); C137(1.10)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C128(1.24); C137(1.24)  LDD0592  [3]
 LDCM0367  CL1 HCT 116 C128(1.31); C137(1.31)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C128(1.80); C137(1.80)  LDD0685  [3]
 LDCM0369  CL100 HEK-293T C128(0.83); C137(0.80)  LDD0967  [3]
 LDCM0370  CL101 HCT 116 C128(1.20); C137(1.20)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C128(1.10); C137(1.10)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C128(1.30); C137(1.30)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C128(1.24); C137(1.24)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C128(1.28); C137(1.28)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C128(1.27); C137(1.27)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C128(1.21); C137(1.21)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C128(1.35); C137(1.35)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C128(1.33); C137(1.33)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C128(1.27); C137(1.27)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C128(1.69); C137(1.69)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C128(1.33); C137(1.33)  LDD0698  [3]
 LDCM0382  CL112 PaTu 8988t C369(0.90); C373(0.90); C128(0.87); C137(0.87)  LDD1261  [3]
 LDCM0383  CL113 PaTu 8988t C369(0.94); C373(0.94); C128(1.07); C137(1.07)  LDD1262  [3]
 LDCM0384  CL114 PaTu 8988t C369(1.15); C373(1.15); C128(0.97); C137(0.97)  LDD1263  [3]
 LDCM0385  CL115 PaTu 8988t C369(0.98); C373(0.98); C128(1.05); C137(1.05)  LDD1264  [3]
 LDCM0386  CL116 PaTu 8988t C369(0.96); C373(0.96); C128(0.87); C137(0.87)  LDD1265  [3]
 LDCM0387  CL117 HCT 116 C128(1.32); C137(1.32)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C128(0.92); C137(0.92)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C128(1.10); C137(1.10)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C128(1.18); C137(1.18)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C128(1.12); C137(1.12)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C128(1.42); C137(1.42)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C128(1.12); C137(1.12)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C128(2.28); C137(2.28)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C128(1.22); C137(1.22)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C128(0.94); C137(0.94)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C128(0.65); C137(0.65)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C128(1.02); C137(1.02)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C128(0.91); C137(0.91)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C128(1.07); C137(1.07)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C128(1.41); C137(1.41)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C128(1.50); C137(1.50)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C128(0.83); C137(0.83)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C128(1.23); C137(1.23)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C128(0.77); C137(0.77)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C128(0.90); C137(0.90)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C128(0.94); C137(0.94)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C128(0.90); C137(0.90)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C128(1.39); C137(1.39)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C128(1.29); C137(1.29)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C128(0.97); C137(0.97)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C128(1.04); C137(1.04)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C128(1.22); C137(1.22)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C128(0.97); C137(0.97)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C128(0.89); C137(0.89)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C128(0.90); C137(0.90)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C128(0.76); C137(0.76)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C128(0.99); C137(0.99)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C128(0.83); C137(0.83)  LDD0736  [3]
 LDCM0420  CL31 HEK-293T C137(1.08)  LDD1018  [3]
 LDCM0421  CL32 HEK-293T C137(0.98)  LDD1019  [3]
 LDCM0422  CL33 HEK-293T C137(0.84)  LDD1020  [3]
 LDCM0423  CL34 HEK-293T C137(0.92)  LDD1021  [3]
 LDCM0424  CL35 HEK-293T C137(1.02)  LDD1022  [3]
 LDCM0425  CL36 HEK-293T C137(0.96)  LDD1023  [3]
 LDCM0426  CL37 HEK-293T C137(0.99)  LDD1024  [3]
 LDCM0428  CL39 HEK-293T C137(0.71)  LDD1026  [3]
 LDCM0429  CL4 HCT 116 C128(1.07); C137(1.07)  LDD0746  [3]
 LDCM0430  CL40 HEK-293T C137(0.96)  LDD1028  [3]
 LDCM0431  CL41 HEK-293T C137(0.73)  LDD1029  [3]
 LDCM0432  CL42 HEK-293T C137(0.76)  LDD1030  [3]
 LDCM0433  CL43 HEK-293T C137(0.72)  LDD1031  [3]
 LDCM0434  CL44 HEK-293T C137(1.05)  LDD1032  [3]
 LDCM0435  CL45 HEK-293T C137(0.75)  LDD1033  [3]
 LDCM0436  CL46 HCT 116 C128(0.77); C137(0.77)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C128(0.77); C137(0.77)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C128(0.72); C137(0.72)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C128(0.89); C137(0.89)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C128(0.93); C137(0.93)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C128(0.82); C137(0.82)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C128(0.74); C137(0.74)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C128(0.84); C137(0.84)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C128(0.87); C137(0.87)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C128(0.84); C137(0.84)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C128(0.81); C137(0.81)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C128(0.80); C137(0.80)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C128(0.93); C137(0.93)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C128(0.78); C137(0.78)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C128(0.81); C137(0.81)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C128(1.31); C137(1.31)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C128(0.88); C137(0.88)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C128(0.98); C137(0.98)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C128(1.01); C137(1.01)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C128(0.93); C137(0.93)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C128(1.26); C137(1.26)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C128(0.96); C137(0.96)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C128(1.26); C137(1.26)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C128(1.20); C137(1.20)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C128(1.13); C137(1.13)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C128(0.89); C137(0.89)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C128(1.10); C137(1.10)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C128(0.96); C137(0.96)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C128(1.01); C137(1.01)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C128(1.01); C137(1.01)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C128(1.14); C137(1.14)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C128(1.05); C137(1.05)  LDD0784  [3]
 LDCM0469  CL76 HEK-293T C137(0.66)  LDD1067  [3]
 LDCM0470  CL77 HEK-293T C137(0.69)  LDD1068  [3]
 LDCM0471  CL78 HEK-293T C137(0.61)  LDD1069  [3]
 LDCM0472  CL79 HEK-293T C137(0.64)  LDD1070  [3]
 LDCM0473  CL8 HCT 116 C128(2.00); C137(2.00)  LDD0790  [3]
 LDCM0474  CL80 HEK-293T C137(0.62)  LDD1072  [3]
 LDCM0475  CL81 HEK-293T C137(0.76)  LDD1073  [3]
 LDCM0476  CL82 HEK-293T C137(0.94)  LDD1074  [3]
 LDCM0477  CL83 HEK-293T C137(0.77)  LDD1075  [3]
 LDCM0478  CL84 HEK-293T C137(0.67)  LDD1076  [3]
 LDCM0479  CL85 HEK-293T C137(0.65)  LDD1077  [3]
 LDCM0480  CL86 HEK-293T C137(0.53)  LDD1078  [3]
 LDCM0481  CL87 HEK-293T C137(0.65)  LDD1079  [3]
 LDCM0482  CL88 HEK-293T C137(0.66)  LDD1080  [3]
 LDCM0483  CL89 HEK-293T C137(0.69)  LDD1081  [3]
 LDCM0484  CL9 HCT 116 C128(1.03); C137(1.03)  LDD0801  [3]
 LDCM0485  CL90 HEK-293T C137(0.65)  LDD1083  [3]
 LDCM0486  CL91 HEK-293T C128(1.05); C137(1.21)  LDD1084  [3]
 LDCM0487  CL92 HEK-293T C128(0.85); C137(0.82)  LDD1085  [3]
 LDCM0488  CL93 HEK-293T C128(0.95); C137(0.92)  LDD1086  [3]
 LDCM0489  CL94 HEK-293T C128(0.78); C137(0.94)  LDD1087  [3]
 LDCM0490  CL95 HEK-293T C128(0.72); C137(0.88)  LDD1088  [3]
 LDCM0491  CL96 HEK-293T C128(0.89); C137(1.03)  LDD1089  [3]
 LDCM0492  CL97 HEK-293T C128(0.91); C137(1.13)  LDD1090  [3]
 LDCM0493  CL98 HEK-293T C128(0.83); C137(0.95)  LDD1091  [3]
 LDCM0494  CL99 HEK-293T C128(0.89); C137(0.89)  LDD1092  [3]
 LDCM0495  E2913 HEK-293T C63(1.13); C78(0.97)  LDD1698  [6]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C63(5.52); C331(5.24)  LDD1702  [2]
 LDCM0625  F8 Ramos C331(1.61); C63(1.12)  LDD2187  [7]
 LDCM0572  Fragment10 Ramos C331(1.21); C63(2.57)  LDD2189  [7]
 LDCM0573  Fragment11 Ramos C331(1.32); C63(5.88)  LDD2190  [7]
 LDCM0574  Fragment12 Ramos C63(6.49)  LDD2191  [7]
 LDCM0575  Fragment13 Ramos C63(1.11)  LDD2192  [7]
 LDCM0576  Fragment14 Ramos C331(1.60); C63(7.29)  LDD2193  [7]
 LDCM0579  Fragment20 Ramos C331(0.92); C63(9.19)  LDD2194  [7]
 LDCM0580  Fragment21 Ramos C63(1.12)  LDD2195  [7]
 LDCM0582  Fragment23 Ramos C331(0.55); C63(0.57)  LDD2196  [7]
 LDCM0578  Fragment27 Ramos C331(2.50); C63(0.80)  LDD2197  [7]
 LDCM0586  Fragment28 Ramos C63(0.45)  LDD2198  [7]
 LDCM0588  Fragment30 Ramos C331(2.41); C63(1.18)  LDD2199  [7]
 LDCM0589  Fragment31 Ramos C63(1.07)  LDD2200  [7]
 LDCM0590  Fragment32 Ramos C63(4.81)  LDD2201  [7]
 LDCM0468  Fragment33 HCT 116 C128(1.07); C137(1.07)  LDD0785  [3]
 LDCM0596  Fragment38 Ramos C331(1.75); C63(1.92)  LDD2203  [7]
 LDCM0566  Fragment4 Ramos C63(3.30)  LDD2184  [7]
 LDCM0427  Fragment51 HEK-293T C137(0.97)  LDD1025  [3]
 LDCM0610  Fragment52 Ramos C63(1.62)  LDD2204  [7]
 LDCM0614  Fragment56 Ramos C331(1.33); C63(1.17)  LDD2205  [7]
 LDCM0569  Fragment7 Ramos C331(0.91); C63(6.95)  LDD2186  [7]
 LDCM0022  KB02 Ramos C331(1.52)  LDD2182  [7]
 LDCM0023  KB03 Ramos C63(6.29)  LDD2183  [7]
 LDCM0024  KB05 OV-90 C340(1.44)  LDD3380  [8]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C63(0.86)  LDD2123  [2]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C63(1.13)  LDD2129  [2]
 LDCM0628  OTUB2-COV-1 HEK-293T C63(4.24); C78(0.70)  LDD2207  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mitochondrial peptide methionine sulfoxide reductase (MSRA) MsrA Met sulfoxide reductase family Q9UJ68
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
PRKCA-binding protein (PICK1) . Q9NRD5

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
9 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.