Details of the Target

General Information of Target

Target ID LDTP13469
Target Name PR domain zinc finger protein 4 (PRDM4)
Gene Name PRDM4
Gene ID 11108
Synonyms
PFM1; PR domain zinc finger protein 4; EC 2.1.1.-; PR domain-containing protein 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLVIWILTLALRLCASVTTVTPEGSAVHKAISQQGTLWTGEVLEKQTVEQGKSTLRRQKN
HFHRSAGELRCRNALKDEGASAGWSVMFAGESVVVLVHLWMTGARVKNLGLVEFASPGDD
GDGRAEGFSLGLPLSEQARAAGAREKERQETVINHSTFSGFSQITGSTVNTSIGGNTTSA
STPSSSDPFTTFSDYGVSVTFITGSTATKHFLDSSTNSGHSEESTVSHSGPGATGTTLFP
SHSATSVFVGEPKTSPITSASMETTALPGSTTTAGLSEKSTTFYSSPRSPDRTLSPARTT
SSGVSEKSTTSHSRPGPTHTIAFPDSTTMPGVSQESTASHSIPGSTDTTLSPGTTTPSSL
GPESTTFHSSPGYTKTTRLPDNTTTSGLLEASTPVHSSTGSPHTTLSPSSSTTHEGEPTT
FQSWPSSKDTSPAPSGTTSAFVKLSTTYHSSPSSTPTTHFSASSTTLGHSEESTPVHSSP
VATATTPPPARSATSGHVEESTAYHRSPGSTQTMHFPESSTTSGHSEESATFHGSTTHTK
SSTPSTTAALAHTSYHSSLGSTETTHFRDSSTISGRSEESKASHSSPDAMATTVLPAGST
PSVLVGDSTPSPISSGSMETTALPGSTTKPGLSEKSTTFYSSPRSPDTTHLPASMTSSGV
SEESTTSHSRPGSTHTTAFPGSTTMPGLSQESTASHSSPGPTDTTLSPGSTTASSLGPEY
TTFHSRPGSTETTLLPDNTTASGLLEASMPVHSSTRSPHTTLSPAGSTTRQGESTTFHSW
PSSKDTRPAPPTTTSAFVEPSTTSHGSPSSIPTTHISARSTTSGLVEESTTYHSSPGSTQ
TMHFPESDTTSGRGEESTTSHSSTTHTISSAPSTTSALVEEPTSYHSSPGSTATTHFPDS
STTSGRSEESTASHSSQDATGTIVLPARSTTSVLLGESTTSPISSGSMETTALPGSTTTP
GLSERSTTFHSSPRSPATTLSPASTTSSGVSEESTTSRSRPGSTHTTAFPDSTTTPGLSR
HSTTSHSSPGSTDTTLLPASTTTSGPSQESTTSHSSSGSTDTALSPGSTTALSFGQESTT
FHSNPGSTHTTLFPDSTTSSGIVEASTRVHSSTGSPRTTLSPASSTSPGLQGESTAFQTH
PASTHTTPSPPSTATAPVEESTTYHRSPGSTPTTHFPASSTTSGHSEKSTIFHSSPDASG
TTPSSAHSTTSGRGESTTSRISPGSTEITTLPGSTTTPGLSEASTTFYSSPRSPTTTLSP
ASMTSLGVGEESTTSRSQPGSTHSTVSPASTTTPGLSEESTTVYSSSRGSTETTVFPHST
TTSVHGEEPTTFHSRPASTHTTLFTEDSTTSGLTEESTAFPGSPASTQTGLPATLTTADL
GEESTTFPSSSGSTGTKLSPARSTTSGLVGESTPSRLSPSSTETTTLPGSPTTPSLSEKS
TTFYTSPRSPDATLSPATTTSSGVSEESSTSHSQPGSTHTTAFPDSTTTSDLSQEPTTSH
SSQGSTEATLSPGSTTASSLGQQSTTFHSSPGDTETTLLPDDTITSGLVEASTPTHSSTG
SLHTTLTPASSTSAGLQEESTTFQSWPSSSDTTPSPPGTTAAPVEVSTTYHSRPSSTPTT
HFSASSTTLGRSEESTTVHSSPGATGTALFPTRSATSVLVGEPTTSPISSGSTETTALPG
STTTAGLSEKSTTFYSSPRSPDTTLSPASTTSSGVSEESTTSHSRPGSTHTTAFPGSTTM
PGVSQESTASHSSPGSTDTTLSPGSTTASSLGPESTTFHSSPGSTETTLLPDNTTASGLL
EASTPVHSSTGSPHTTLSPAGSTTRQGESTTFQSWPSSKDTMPAPPTTTSAFVELSTTSH
GSPSSTPTTHFSASSTTLGRSEESTTVHSSPVATATTPSPARSTTSGLVEESTAYHSSPG
STQTMHFPESSTASGRSEESRTSHSSTTHTISSPPSTTSALVEEPTSYHSSPGSTATTHF
PDSSTTSGRSEESTASHSSQDATGTIVLPARSTTSVLLGESTTSPISSGSMETTALPGST
TTPGLSEKSTTFHSSPRSPATTLSPASTTSSGVSEESTTSHSRPGSTHTTAFPDSTTTPG
LSRHSTTSHSSPGSTDTTLLPASTTTSGPSQESTTSHSSPGSTDTALSPGSTTALSFGQE
STTFHSSPGSTHTTLFPDSTTSSGIVEASTRVHSSTGSPRTTLSPASSTSPGLQGESTAF
QTHPASTHTTPSPPSTATAPVEESTTYHRSPGSTPTTHFPASSTTSGHSEKSTIFHSSPD
ASGTTPSSAHSTTSGRGESTTSRISPGSTEITTLPGSTTTPGLSEASTTFYSSPRSPTTT
LSPASMTSLGVGEESTTSRSQPGSTHSTVSPASTTTPGLSEESTTVYSSSPGSTETTVFP
RTPTTSVRGEEPTTFHSRPASTHTTLFTEDSTTSGLTEESTAFPGSPASTQTGLPATLTT
ADLGEESTTFPSSSGSTGTTLSPARSTTSGLVGESTPSRLSPSSTETTTLPGSPTTPSLS
EKSTTFYTSPRSPDATLSPATTTSSGVSEESSTSHSQPGSTHTTAFPDSTTTPGLSRHST
TSHSSPGSTDTTLLPASTTTSGPSQESTTSHSSPGSTDTALSPGSTTALSFGQESTTFHS
SPGSTHTTLFPDSTTSSGIVEASTRVHSSTGSPRTTLSPASSTSPGLQGESTTFQTHPAS
THTTPSPPSTATAPVEESTTYHRSPGSTPTTHFPASSTTSGHSEKSTIFHSSPDASGTTP
SSAHSTTSGRGESTTSRISPGSTEITTLPGSTTTPGLSEASTTFYSSPRSPTTTLSPASM
TSLGVGEESTTSRSQPGSTHSTVSPASTTTPGLSEESTTVYSSSPGSTETTVFPRSTTTS
VRGEEPTTFHSRPASTHTTLFTEDSTTSGLTEESTAFPGSPASTQTGLPATLTTADLGEE
STTFPSSSGSTGTTLSPARSTTSGLVGESTPSRLSPSSTETTTLPGSPTTPSLSEKSTTF
YTSPRSPDATLSPATTTSSGVSEESSTSHSQPGSTHTTAFPDSTTTSGLSQEPTASHSSQ
GSTEATLSPGSTTASSLGQQSTTFHSSPGDTETTLLPDDTITSGLVEASTPTHSSTGSLH
TTLTPASSTSAGLQEESTTFQSWPSSSDTTPSPPGTTAAPVEVSTTYHSRPSSTPTTHFS
ASSTTLGRSEESTTVHSSPGATGTALFPTRSATSVLVGEPTTSPISSGSTETTALPGSTT
TAGLSEKSTTFYSSPRSPDTTLSPASTTSSGVSEESTTSHSRPGSTHTTAFPGSTTMPGV
SQESTASHSSPGSTDTTLSPGSTTASSLGPESTTFHSGPGSTETTLLPDNTTASGLLEAS
TPVHSSTGSPHTTLSPAGSTTRQGESTTFQSWPNSKDTTPAPPTTTSAFVELSTTSHGSP
SSTPTTHFSASSTTLGRSEESTTVHSSPVATATTPSPARSTTSGLVEESTTYHSSPGSTQ
TMHFPESDTTSGRGEESTTSHSSTTHTISSAPSTTSALVEEPTSYHSSPGSTATTHFPDS
STTSGRSEESTASHSSQDATGTIVLPARSTTSVLLGESTTSPISSGSMETTALPGSTTTP
GLSEKSTTFHSSPRSPATTLSPASTTSSGVSEESTTSHSRPGSTHTTAFPDSTTTPGLSR
HSTTSHSSPGSTDTTLLPASTTTSGSSQESTTSHSSSGSTDTALSPGSTTALSFGQESTT
FHSSPGSTHTTLFPDSTTSSGIVEASTRVHSSTGSPRTTLSPASSTSPGLQGESTAFQTH
PASTHTTPSPPSTATAPVEESTTYHRSPGSTPTTHFPASSTTSGHSEKSTIFHSSPDASG
TTPSSAHSTTSGRGESTTSRISPGSTEITTLPGSTTTPGLSEASTTFYSSPRSPTTTLSP
ASMTSLGVGEESTTSRSQPGSTHSTVSPASTTTPGLSEESTTVYSSSPGSTETTVFPRST
TTSVRREEPTTFHSRPASTHTTLFTEDSTTSGLTEESTAFPGSPASTQTGLPATLTTADL
GEESTTFPSSSGSTGTKLSPARSTTSGLVGESTPSRLSPSSTETTTLPGSPTTPSLSEKS
TTFYTSPRSPDATLSPATTTSSGVSEESSTSHSQPGSTHTTAFPDSTTTSGLSQEPTTSH
SSQGSTEATLSPGSTTASSLGQQSTTFHSSPGDTETTLLPDDTITSGLVEASTPTHSSTG
SLHTTLTPASSTSTGLQEESTTFQSWPSSSDTTPSPPSTTAVPVEVSTTYHSRPSSTPTT
HFSASSTTLGRSEESTTVHSSPGATGTALFPTRSATSVLVGEPTTSPISSGSTETTALPG
STTTAGLSEKSTTFYSSPRSPDTTLSPASTTSSGVSEESTTSHSRPGSMHTTAFPSSTTM
PGVSQESTASHSSPGSTDTTLSPGSTTASSLGPESTTFHSSPGSTETTLLPDNTTASGLL
EASTPVHSSTGSPHTTLSPAGSTTRQGESTTFQSWPNSKDTTPAPPTTTSAFVELSTTSH
GSPSSTPTTHFSASSTTLGRSEESTTVHSSPVATATTPSPARSTTSGLVEESTTYHSSPG
STQTMHFPESNTTSGRGEESTTSHSSTTHTISSAPSTTSALVEEPTSYHSSPGSTATTHF
PDSSTTSGRSEESTASHSSQDATGTIVLPARSTTSVLLGESTTSPISSGSMETTALPGST
TTPGLSEKSTTFHSSPSSTPTTHFSASSTTLGRSEESTTVHSSPVATATTPSPARSTTSG
LVEESTAYHSSPGSTQTMHFPESSTASGRSEESRTSHSSTTHTISSPPSTTSALVEEPTS
YHSSPGSIATTHFPESSTTSGRSEESTASHSSPDTNGITPLPAHFTTSGRIAESTTFYIS
PGSMETTLASTATTPGLSAKSTILYSSSRSPDQTLSPASMTSSSISGEPTSLYSQAESTH
TTAFPASTTTSGLSQESTTFHSKPGSTETTLSPGSITTSSFAQEFTTPHSQPGSALSTVS
PASTTVPGLSEESTTFYSSPGSTETTAFSHSNTMSIHSQQSTPFPDSPGFTHTVLPATLT
TTDIGQESTAFHSSSDATGTTPLPARSTASDLVGEPTTFYISPSPTYTTLFPASSSTSGL
TEESTTFHTSPSFTSTIVSTESLETLAPGLCQEGQIWNGKQCVCPQGYVGYQCLSPLESF
PVETPEKLNATLGMTVKVTYRNFTEKMNDASSQEYQNFSTLFKNRMDVVLKGDNLPQYRG
VNIRRLLNGSIVVKNDVILEADYTLEYEELFENLAEIVKAKIMNETRTTLLDPDSCRKAI
LCYSEEDTFVDSSVTPGFDFQEQCTQKAAEGYTQFYYVDVLDGKLACVNKCTKGTKSQMN
CNLGTCQLQRSGPRCLCPNTNTHWYWGETCEFNIAKSLVYGIVGAVMAVLLLALIILIIL
FSLSQRKRHREQYDVPQEWRKEGTPGIFQKTAIWEDQNLRESRFGLENAYNNFRPTLETV
DSGTELHIQRPEMVASTV
Target Bioclass
Enzyme
Family
Class V-like SAM-binding methyltransferase superfamily
Subcellular location
Nucleus
Function May function as a transcription factor involved in cell differentiation.
Uniprot ID
Q9UKN5
Ensemble ID
ENST00000228437.10
HGNC ID
HGNC:9348

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C547(1.92); C549(1.92)  LDD0080  [1]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C547(1.11); C549(1.11)  LDD0531  [1]
 LDCM0215  AC10 HEK-293T C547(0.92)  LDD0813  [1]
 LDCM0216  AC100 HCT 116 C547(0.87); C549(0.87)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C547(0.93); C549(0.93)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C547(1.08); C549(1.08)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C547(0.75); C549(0.75)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C547(0.81); C549(0.81)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C547(0.90); C549(0.90)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C547(0.83); C549(0.83)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C547(0.99); C549(0.99)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C547(0.68); C549(0.71)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C547(0.75); C549(0.85)  LDD0542  [1]
 LDCM0226  AC11 HEK-293T C547(1.05)  LDD0824  [1]
 LDCM0227  AC110 HCT 116 C547(0.85); C549(0.85)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C547(0.84); C549(0.89)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C547(0.79); C549(0.83)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C547(0.93); C549(0.93)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C547(1.12); C549(1.12)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C547(1.37); C549(1.37)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C547(1.32); C549(1.32)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C547(1.19); C549(1.19)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C547(1.31); C549(1.31)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C547(1.20); C549(1.20)  LDD0553  [1]
 LDCM0237  AC12 HEK-293T C547(0.88)  LDD0835  [1]
 LDCM0238  AC120 HCT 116 C547(1.28); C549(1.28)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C547(1.07); C549(1.07)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C547(1.11); C549(1.11)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C547(1.59); C549(1.59)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C547(1.31); C549(1.31)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C547(1.07); C549(1.07)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C547(1.19); C549(1.19)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C547(1.20); C549(1.20)  LDD0562  [1]
 LDCM0259  AC14 HEK-293T C547(1.13)  LDD0857  [1]
 LDCM0263  AC143 HCT 116 C547(0.85); C549(0.85)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C547(1.10); C549(1.10)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C547(0.95); C549(0.95)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C547(0.89); C549(0.89)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C547(1.07); C549(1.07)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C547(1.31); C549(1.31)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C547(1.08); C549(1.08)  LDD0586  [1]
 LDCM0270  AC15 HEK-293T C547(0.90)  LDD0868  [1]
 LDCM0271  AC150 HCT 116 C547(0.82); C549(0.82)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C547(0.88); C549(0.88)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C547(0.99); C549(0.99)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C547(1.27); C549(1.27)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C547(1.21); C549(1.21)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C547(1.06); C549(1.06)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C547(1.05); C549(1.05)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C547(0.90); C549(0.90)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C547(0.88); C549(0.88)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C547(1.12); C549(1.12)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C547(0.98); C549(0.98)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C547(1.07); C549(1.07)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C547(0.92); C549(0.92)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C547(0.98); C549(0.98)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C547(0.88); C549(0.88)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C547(0.84); C549(0.84)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C547(0.99); C549(0.99)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C547(1.04); C549(1.04)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C547(1.04); C549(1.04)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C547(0.93); C549(0.93)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C547(0.88); C549(0.88)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C547(1.03); C549(1.03)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C547(1.08); C549(1.08)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C547(1.23); C549(1.23)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C547(1.05); C549(1.05)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C547(1.01); C549(1.01)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C547(1.21); C549(1.21)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C547(1.08); C549(1.08)  LDD0612  [1]
 LDCM0296  AC35 HEK-293T C547(0.92)  LDD0894  [1]
 LDCM0297  AC36 HEK-293T C547(1.06)  LDD0895  [1]
 LDCM0298  AC37 HEK-293T C547(0.77)  LDD0896  [1]
 LDCM0299  AC38 HEK-293T C547(1.01)  LDD0897  [1]
 LDCM0300  AC39 HEK-293T C547(1.16)  LDD0898  [1]
 LDCM0301  AC4 HCT 116 C547(1.29); C549(1.29)  LDD0618  [1]
 LDCM0302  AC40 HEK-293T C547(1.00)  LDD0900  [1]
 LDCM0303  AC41 HEK-293T C547(1.03)  LDD0901  [1]
 LDCM0304  AC42 HEK-293T C547(1.19)  LDD0902  [1]
 LDCM0305  AC43 HEK-293T C547(0.93)  LDD0903  [1]
 LDCM0306  AC44 HEK-293T C547(1.00)  LDD0904  [1]
 LDCM0307  AC45 HEK-293T C547(0.90)  LDD0905  [1]
 LDCM0308  AC46 HEK-293T C83(1.41)  LDD1547  [3]
 LDCM0312  AC5 HCT 116 C547(1.33); C549(1.33)  LDD0629  [1]
 LDCM0313  AC50 HEK-293T C83(0.86)  LDD1552  [3]
 LDCM0317  AC54 HEK-293T C83(1.25)  LDD1556  [3]
 LDCM0320  AC57 HCT 116 C547(1.14); C549(1.14)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C547(1.27); C549(1.27)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C547(1.08); C549(1.08)  LDD0639  [1]
 LDCM0323  AC6 HEK-293T C547(1.17)  LDD0921  [1]
 LDCM0324  AC60 HCT 116 C547(1.50); C549(1.50)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C547(1.01); C549(1.01)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C547(1.17); C549(1.17)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C547(1.30); C549(1.30)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C547(1.38); C549(1.38)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C547(1.30); C549(1.30)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C547(1.43); C549(1.43)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C547(1.09); C549(1.09)  LDD0648  [1]
 LDCM0334  AC7 HEK-293T C547(0.98)  LDD0932  [1]
 LDCM0345  AC8 HEK-293T C547(0.88)  LDD0943  [1]
 LDCM0349  AC83 HCT 116 C547(1.04); C549(1.04)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C547(1.01); C549(1.01)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C547(0.96); C549(0.96)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C547(1.05); C549(1.05)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C547(0.88); C549(0.88)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C547(0.90); C549(0.90)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C547(1.01); C549(1.01)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C547(1.06); C549(1.06)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C547(0.89); C549(0.89)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C547(0.99); C549(0.99)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C547(0.97); C549(0.97)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C547(0.94); C549(0.94)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C547(0.88); C549(0.88)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C547(0.91); C549(0.91)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C547(0.94); C549(0.94)  LDD0681  [1]
 LDCM0365  AC98 HCT 116 C547(0.92); C549(0.92)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C547(0.80); C549(0.80)  LDD0683  [1]
 LDCM0248  AKOS034007472 HEK-293T C547(0.92)  LDD0846  [1]
 LDCM0356  AKOS034007680 HEK-293T C547(0.95)  LDD0954  [1]
 LDCM0275  AKOS034007705 HEK-293T C547(0.94)  LDD0873  [1]
 LDCM0367  CL1 HCT 116 C547(1.19); C549(1.19)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C547(1.04); C549(1.04)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C547(1.04); C549(1.04)  LDD0686  [1]
 LDCM0370  CL101 HEK-293T C547(0.96)  LDD0968  [1]
 LDCM0371  CL102 HEK-293T C547(0.87)  LDD0969  [1]
 LDCM0372  CL103 HEK-293T C547(0.86)  LDD0970  [1]
 LDCM0373  CL104 HEK-293T C547(0.92)  LDD0971  [1]
 LDCM0374  CL105 HCT 116 C547(0.96); C549(0.96)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C547(1.23); C549(1.23)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C547(1.09); C549(1.09)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C547(1.25); C549(1.25)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C547(1.00); C549(1.00)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C547(1.26); C549(1.26)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C547(0.89); C549(0.89)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C547(0.84); C549(0.84)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C547(0.99); C549(0.99)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C547(0.92); C549(0.92)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C547(0.89); C549(0.89)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C547(1.17); C549(1.17)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C547(1.11); C549(1.11)  LDD0703  [1]
 LDCM0387  CL117 HEK-293T C547(0.94)  LDD0985  [1]
 LDCM0388  CL118 HEK-293T C547(1.02)  LDD0986  [1]
 LDCM0389  CL119 HEK-293T C547(0.93)  LDD0987  [1]
 LDCM0390  CL12 HCT 116 C547(1.30); C549(1.30)  LDD0707  [1]
 LDCM0391  CL120 HEK-293T C547(0.98)  LDD0989  [1]
 LDCM0392  CL121 HEK-293T C83(1.18)  LDD1596  [3]
 LDCM0393  CL122 HEK-293T C83(1.03)  LDD1597  [3]
 LDCM0394  CL123 HEK-293T C83(0.92)  LDD1598  [3]
 LDCM0396  CL125 HCT 116 C547(1.14); C549(1.14)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C547(1.05); C549(1.05)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C547(0.90); C549(0.90)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C547(1.18); C549(1.18)  LDD0716  [1]
 LDCM0400  CL13 HCT 116 C547(1.15); C549(1.15)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C547(1.16); C549(1.16)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C547(1.40); C549(1.40)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C547(1.34); C549(1.34)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C547(0.99); C549(0.99)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C547(1.25); C549(1.25)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C547(1.40); C549(1.40)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C547(1.18); C549(1.18)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C547(1.51); C549(1.51)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C547(1.24); C549(1.24)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C547(1.89); C549(1.89)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C547(1.05); C549(1.05)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C547(1.32); C549(1.32)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C547(1.38); C549(1.38)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C547(1.42); C549(1.42)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C547(1.10); C549(1.10)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C547(1.42); C549(1.42)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C547(1.24); C549(1.24)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C547(1.08); C549(1.08)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C547(1.23); C549(1.23)  LDD0736  [1]
 LDCM0423  CL34 HEK-293T C83(1.06)  LDD1627  [3]
 LDCM0426  CL37 HEK-293T C83(1.12)  LDD1630  [3]
 LDCM0428  CL39 HEK-293T C83(1.04)  LDD1632  [3]
 LDCM0429  CL4 HCT 116 C547(1.01); C549(1.01)  LDD0746  [1]
 LDCM0432  CL42 HEK-293T C83(1.18)  LDD1636  [3]
 LDCM0436  CL46 HCT 116 C547(1.03); C549(1.03)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C547(0.92); C549(0.92)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C547(0.98); C549(0.98)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C547(0.98); C549(0.98)  LDD0756  [1]
 LDCM0440  CL5 HCT 116 C547(1.15); C549(1.15)  LDD0757  [1]
 LDCM0441  CL50 HCT 116 C547(0.99); C549(0.99)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C547(0.86); C549(0.86)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C547(1.20); C549(1.20)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C547(0.94); C549(0.94)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C547(0.89); C549(0.89)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C547(0.88); C549(0.88)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C547(1.04); C549(1.04)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C547(0.94); C549(0.94)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C547(1.10); C549(1.10)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C547(0.93); C549(0.93)  LDD0767  [1]
 LDCM0451  CL6 HCT 116 C547(1.40); C549(1.40)  LDD0768  [1]
 LDCM0452  CL60 HCT 116 C547(1.07); C549(1.07)  LDD0769  [1]
 LDCM0453  CL61 HCT 116 C547(0.98); C549(0.98)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C547(0.95); C549(0.95)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C547(1.04); C549(1.04)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C547(1.06); C549(1.06)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C547(0.98); C549(0.98)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C547(1.18); C549(1.18)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C547(0.96); C549(0.96)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C547(1.08); C549(1.08)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C547(1.22); C549(1.22)  LDD0778  [1]
 LDCM0462  CL7 HCT 116 C547(1.36); C549(1.36)  LDD0779  [1]
 LDCM0463  CL70 HCT 116 C547(1.00); C549(1.00)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C547(0.99); C549(0.99)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C547(1.05); C549(1.05)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C547(1.05); C549(1.05)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C547(0.96); C549(0.96)  LDD0784  [1]
 LDCM0471  CL78 HEK-293T C83(0.73)  LDD1674  [3]
 LDCM0473  CL8 HCT 116 C547(1.28); C549(1.28)  LDD0790  [1]
 LDCM0476  CL82 HEK-293T C83(0.96)  LDD1679  [3]
 LDCM0479  CL85 HEK-293T C83(1.16)  LDD1682  [3]
 LDCM0480  CL86 HEK-293T C83(0.95)  LDD1683  [3]
 LDCM0481  CL87 HEK-293T C83(0.83)  LDD1684  [3]
 LDCM0484  CL9 HCT 116 C547(1.12); C549(1.12)  LDD0801  [1]
 LDCM0485  CL90 HEK-293T C83(1.18)  LDD1688  [3]
 LDCM0486  CL91 HCT 116 C547(1.00); C549(1.00)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C547(0.95); C549(0.95)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C547(0.97); C549(0.97)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C547(1.10); C549(1.10)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C547(0.96); C549(0.96)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C547(1.18); C549(1.18)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C547(1.32); C549(1.32)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C547(1.06); C549(1.06)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C547(1.08); C549(1.08)  LDD0811  [1]
 LDCM0495  E2913 HEK-293T C83(1.45)  LDD1698  [3]
 LDCM0468  Fragment33 HCT 116 C547(1.07); C549(1.07)  LDD0785  [1]
 LDCM0427  Fragment51 HEK-293T C83(0.93)  LDD1631  [3]
 LDCM0022  KB02 HCT 116 C547(1.92); C549(1.92)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C547(1.80); C549(1.80)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C547(1.83); C549(1.83)  LDD0082  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Methionine-R-sulfoxide reductase B3 (MSRB3) MsrB Met sulfoxide reductase family Q8IXL7
E3 ubiquitin-protein ligase NEDD4 (NEDD4) . P46934
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Neuronal calcium sensor 1 (NCS1) Recoverin family P62166
Beta-catenin-like protein 1 (CTNNBL1) . Q8WYA6

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402