Details of the Target

General Information of Target

Target ID LDTP13158
Target Name DNA polymerase kappa (POLK)
Gene Name POLK
Gene ID 51426
Synonyms
DINB1; DNA polymerase kappa; EC 2.7.7.7; DINB protein; DINP
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MVAAVLLGLSWLCSPLGALVLDFNNIRSSADLHGARKGSQCLSDTDCNTRKFCLQPRDEK
PFCATCRGLRRRCQRDAMCCPGTLCVNDVCTTMEDATPILERQLDEQDGTHAEGTTGHPV
QENQPKRKPSIKKSQGRKGQEGESCLRTFDCGPGLCCARHFWTKICKPVLLEGQVCSRRG
HKDTAQAPEIFQRCDCGPGLLCRSQLTSNRQHARLRVCQKIEKL
Target Bioclass
Enzyme
Family
DNA polymerase type-Y family
Subcellular location
Nucleus
Function
DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity.
Uniprot ID
Q9UBT6
Ensemble ID
ENST00000241436.9
HGNC ID
HGNC:9183
ChEMBL ID
CHEMBL5365

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
8305C SNV: p.I701T .
A172 SNV: p.P732S .
CORL88 SNV: p.K870N .
HSC3 SNV: p.V284F .
MELHO SNV: p.N537K .
MFE319 SNV: p.G774D .
NCIH146 SNV: p.N52Y .
U937 SNV: p.R88I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C681(2.27)  LDD0080  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0164  [2]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [3]
IPM
 Probe Info  		N.A.  LDD0147  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C439(1.38); C782(0.88)  LDD0812  [1]
 LDCM0215  AC10 HEK-293T C439(0.91); C782(0.80)  LDD0813  [1]
 LDCM0216  AC100 HEK-293T C439(1.17); C782(1.09)  LDD0814  [1]
 LDCM0217  AC101 HEK-293T C439(1.00); C782(0.88)  LDD0815  [1]
 LDCM0218  AC102 HEK-293T C439(1.07); C782(0.71)  LDD0816  [1]
 LDCM0219  AC103 HEK-293T C439(1.26); C782(0.72)  LDD0817  [1]
 LDCM0220  AC104 HEK-293T C439(1.04); C782(0.98)  LDD0818  [1]
 LDCM0221  AC105 HEK-293T C439(0.89); C782(1.38)  LDD0819  [1]
 LDCM0222  AC106 HEK-293T C439(0.74); C782(1.28)  LDD0820  [1]
 LDCM0223  AC107 HEK-293T C439(1.02); C782(1.19)  LDD0821  [1]
 LDCM0224  AC108 HEK-293T C439(0.87); C782(1.13)  LDD0822  [1]
 LDCM0225  AC109 HEK-293T C439(0.90); C782(0.93)  LDD0823  [1]
 LDCM0226  AC11 HEK-293T C439(1.17); C782(0.96)  LDD0824  [1]
 LDCM0227  AC110 HEK-293T C439(1.68); C782(0.82)  LDD0825  [1]
 LDCM0228  AC111 HEK-293T C439(2.42); C782(0.85)  LDD0826  [1]
 LDCM0229  AC112 HEK-293T C439(1.89); C782(0.81)  LDD0827  [1]
 LDCM0230  AC113 HEK-293T C782(0.94)  LDD0828  [1]
 LDCM0231  AC114 HEK-293T C782(0.66)  LDD0829  [1]
 LDCM0232  AC115 HEK-293T C782(1.06)  LDD0830  [1]
 LDCM0233  AC116 HEK-293T C782(1.37)  LDD0831  [1]
 LDCM0234  AC117 HEK-293T C782(0.84)  LDD0832  [1]
 LDCM0235  AC118 HEK-293T C782(1.07)  LDD0833  [1]
 LDCM0236  AC119 HEK-293T C782(0.80)  LDD0834  [1]
 LDCM0237  AC12 HEK-293T C439(1.48); C782(0.82)  LDD0835  [1]
 LDCM0238  AC120 HEK-293T C782(1.22)  LDD0836  [1]
 LDCM0239  AC121 HEK-293T C782(0.92)  LDD0837  [1]
 LDCM0240  AC122 HEK-293T C782(0.71)  LDD0838  [1]
 LDCM0241  AC123 HEK-293T C782(1.00)  LDD0839  [1]
 LDCM0242  AC124 HEK-293T C782(0.77)  LDD0840  [1]
 LDCM0243  AC125 HEK-293T C782(0.89)  LDD0841  [1]
 LDCM0244  AC126 HEK-293T C782(0.77)  LDD0842  [1]
 LDCM0245  AC127 HEK-293T C782(0.88)  LDD0843  [1]
 LDCM0246  AC128 HEK-293T C439(0.77); C782(1.07)  LDD0844  [1]
 LDCM0247  AC129 HEK-293T C439(1.21); C782(0.85)  LDD0845  [1]
 LDCM0249  AC130 HEK-293T C439(1.38); C782(0.76)  LDD0847  [1]
 LDCM0250  AC131 HEK-293T C439(1.73); C782(0.89)  LDD0848  [1]
 LDCM0251  AC132 HEK-293T C439(1.19); C782(0.76)  LDD0849  [1]
 LDCM0252  AC133 HEK-293T C439(1.30); C782(0.91)  LDD0850  [1]
 LDCM0253  AC134 HEK-293T C439(1.38); C782(0.88)  LDD0851  [1]
 LDCM0254  AC135 HEK-293T C439(1.24); C782(0.78)  LDD0852  [1]
 LDCM0255  AC136 HEK-293T C439(1.19); C782(0.76)  LDD0853  [1]
 LDCM0256  AC137 HEK-293T C439(1.69); C782(0.78)  LDD0854  [1]
 LDCM0257  AC138 HEK-293T C439(1.73); C782(0.98)  LDD0855  [1]
 LDCM0258  AC139 HEK-293T C439(1.50); C782(0.85)  LDD0856  [1]
 LDCM0259  AC14 HEK-293T C439(0.99); C782(0.65)  LDD0857  [1]
 LDCM0260  AC140 HEK-293T C439(1.27); C782(0.71)  LDD0858  [1]
 LDCM0261  AC141 HEK-293T C439(1.51); C782(0.91)  LDD0859  [1]
 LDCM0262  AC142 HEK-293T C439(1.27); C782(0.91)  LDD0860  [1]
 LDCM0263  AC143 HEK-293T C439(1.21)  LDD0861  [1]
 LDCM0264  AC144 HEK-293T C439(1.52)  LDD0862  [1]
 LDCM0265  AC145 HEK-293T C439(1.61)  LDD0863  [1]
 LDCM0266  AC146 HEK-293T C439(1.73)  LDD0864  [1]
 LDCM0267  AC147 HEK-293T C439(1.71)  LDD0865  [1]
 LDCM0268  AC148 HEK-293T C439(1.49)  LDD0866  [1]
 LDCM0269  AC149 HEK-293T C439(1.16)  LDD0867  [1]
 LDCM0270  AC15 HEK-293T C439(1.52); C782(0.48)  LDD0868  [1]
 LDCM0271  AC150 HEK-293T C439(1.35)  LDD0869  [1]
 LDCM0272  AC151 HEK-293T C439(1.42)  LDD0870  [1]
 LDCM0273  AC152 HEK-293T C439(1.27)  LDD0871  [1]
 LDCM0274  AC153 HEK-293T C439(1.34)  LDD0872  [1]
 LDCM0621  AC154 HEK-293T C439(1.26)  LDD2162  [1]
 LDCM0622  AC155 HEK-293T C439(1.26)  LDD2163  [1]
 LDCM0623  AC156 HEK-293T C439(1.78)  LDD2164  [1]
 LDCM0624  AC157 HEK-293T C439(2.30)  LDD2165  [1]
 LDCM0276  AC17 HEK-293T C782(0.52)  LDD0874  [1]
 LDCM0277  AC18 HEK-293T C782(0.69)  LDD0875  [1]
 LDCM0278  AC19 HEK-293T C782(0.70)  LDD0876  [1]
 LDCM0279  AC2 HEK-293T C439(1.10); C782(0.78)  LDD0877  [1]
 LDCM0280  AC20 HEK-293T C782(0.63)  LDD0878  [1]
 LDCM0281  AC21 HEK-293T C782(1.04)  LDD0879  [1]
 LDCM0282  AC22 HEK-293T C782(0.64)  LDD0880  [1]
 LDCM0283  AC23 HEK-293T C782(0.41)  LDD0881  [1]
 LDCM0284  AC24 HEK-293T C782(0.93)  LDD0882  [1]
 LDCM0285  AC25 HEK-293T C439(1.21); C782(0.97)  LDD0883  [1]
 LDCM0286  AC26 HEK-293T C439(1.36); C782(0.78)  LDD0884  [1]
 LDCM0287  AC27 HEK-293T C439(1.29); C782(0.78)  LDD0885  [1]
 LDCM0288  AC28 HEK-293T C439(1.23); C782(0.83)  LDD0886  [1]
 LDCM0289  AC29 HEK-293T C439(1.17); C782(0.73)  LDD0887  [1]
 LDCM0290  AC3 HEK-293T C439(0.79); C782(0.92)  LDD0888  [1]
 LDCM0291  AC30 HEK-293T C439(1.26); C782(0.86)  LDD0889  [1]
 LDCM0292  AC31 HEK-293T C439(1.03); C782(1.41)  LDD0890  [1]
 LDCM0293  AC32 HEK-293T C439(1.20); C782(0.90)  LDD0891  [1]
 LDCM0294  AC33 HEK-293T C439(1.10); C782(0.79)  LDD0892  [1]
 LDCM0295  AC34 HEK-293T C439(1.06); C782(1.27)  LDD0893  [1]
 LDCM0296  AC35 PaTu 8988t C435(1.00); C439(1.00); C779(1.02); C782(1.02)  LDD1175  [1]
 LDCM0297  AC36 PaTu 8988t C435(0.89); C439(0.89); C779(0.92); C782(0.92)  LDD1176  [1]
 LDCM0298  AC37 PaTu 8988t C435(1.01); C439(1.01); C779(0.87); C782(0.87)  LDD1177  [1]
 LDCM0299  AC38 PaTu 8988t C435(0.97); C439(0.97); C779(1.06); C782(1.06)  LDD1178  [1]
 LDCM0300  AC39 PaTu 8988t C435(0.82); C439(0.82); C779(0.94); C782(0.94)  LDD1179  [1]
 LDCM0301  AC4 HEK-293T C439(1.17); C782(1.03)  LDD0899  [1]
 LDCM0302  AC40 PaTu 8988t C435(0.91); C439(0.91); C779(1.07); C782(1.07)  LDD1181  [1]
 LDCM0303  AC41 PaTu 8988t C435(1.03); C439(1.03); C779(0.93); C782(0.93)  LDD1182  [1]
 LDCM0304  AC42 PaTu 8988t C435(0.88); C439(0.88); C779(0.97); C782(0.97)  LDD1183  [1]
 LDCM0305  AC43 PaTu 8988t C435(0.83); C439(0.83); C779(0.94); C782(0.94)  LDD1184  [1]
 LDCM0306  AC44 PaTu 8988t C435(0.95); C439(0.95); C779(1.25); C782(1.25)  LDD1185  [1]
 LDCM0307  AC45 PaTu 8988t C435(0.93); C439(0.93); C779(1.04); C782(1.04)  LDD1186  [1]
 LDCM0308  AC46 HEK-293T C782(1.01)  LDD0906  [1]
 LDCM0309  AC47 HEK-293T C782(0.89)  LDD0907  [1]
 LDCM0310  AC48 HEK-293T C782(0.83)  LDD0908  [1]
 LDCM0311  AC49 HEK-293T C782(1.04)  LDD0909  [1]
 LDCM0312  AC5 HEK-293T C439(0.94); C782(1.01)  LDD0910  [1]
 LDCM0313  AC50 HEK-293T C782(1.02)  LDD0911  [1]
 LDCM0314  AC51 HEK-293T C782(0.82)  LDD0912  [1]
 LDCM0315  AC52 HEK-293T C782(0.74)  LDD0913  [1]
 LDCM0316  AC53 HEK-293T C782(0.88)  LDD0914  [1]
 LDCM0317  AC54 HEK-293T C782(0.83)  LDD0915  [1]
 LDCM0318  AC55 HEK-293T C782(0.84)  LDD0916  [1]
 LDCM0319  AC56 HEK-293T C782(0.87)  LDD0917  [1]
 LDCM0320  AC57 HEK-293T C439(1.08)  LDD0918  [1]
 LDCM0321  AC58 HEK-293T C439(0.76)  LDD0919  [1]
 LDCM0322  AC59 HEK-293T C439(0.93)  LDD0920  [1]
 LDCM0323  AC6 HEK-293T C439(1.29); C782(0.98)  LDD0921  [1]
 LDCM0324  AC60 HEK-293T C439(0.94)  LDD0922  [1]
 LDCM0325  AC61 HEK-293T C439(1.28)  LDD0923  [1]
 LDCM0326  AC62 HEK-293T C439(1.07)  LDD0924  [1]
 LDCM0327  AC63 HEK-293T C439(1.13)  LDD0925  [1]
 LDCM0328  AC64 HEK-293T C439(1.06)  LDD0926  [1]
 LDCM0329  AC65 HEK-293T C439(1.40)  LDD0927  [1]
 LDCM0330  AC66 HEK-293T C439(0.95)  LDD0928  [1]
 LDCM0331  AC67 HEK-293T C439(1.09)  LDD0929  [1]
 LDCM0332  AC68 HEK-293T C439(1.39); C782(1.58)  LDD0930  [1]
 LDCM0333  AC69 HEK-293T C439(1.31); C782(1.16)  LDD0931  [1]
 LDCM0334  AC7 HEK-293T C439(1.17); C782(0.78)  LDD0932  [1]
 LDCM0335  AC70 HEK-293T C439(1.20); C782(1.22)  LDD0933  [1]
 LDCM0336  AC71 HEK-293T C439(1.16); C782(1.46)  LDD0934  [1]
 LDCM0337  AC72 HEK-293T C439(1.39); C782(1.37)  LDD0935  [1]
 LDCM0338  AC73 HEK-293T C439(1.21); C782(1.15)  LDD0936  [1]
 LDCM0339  AC74 HEK-293T C439(1.46); C782(1.74)  LDD0937  [1]
 LDCM0340  AC75 HEK-293T C439(1.26); C782(1.22)  LDD0938  [1]
 LDCM0341  AC76 HEK-293T C439(1.14); C782(1.11)  LDD0939  [1]
 LDCM0342  AC77 HEK-293T C439(1.26); C782(1.12)  LDD0940  [1]
 LDCM0343  AC78 HEK-293T C439(1.37); C782(2.55)  LDD0941  [1]
 LDCM0344  AC79 HEK-293T C439(1.32); C782(1.01)  LDD0942  [1]
 LDCM0345  AC8 HEK-293T C439(1.17); C782(0.69)  LDD0943  [1]
 LDCM0346  AC80 HEK-293T C439(1.55); C782(0.91)  LDD0944  [1]
 LDCM0347  AC81 HEK-293T C439(1.27); C782(1.55)  LDD0945  [1]
 LDCM0348  AC82 HEK-293T C439(1.71); C782(1.20)  LDD0946  [1]
 LDCM0365  AC98 HEK-293T C439(1.02); C782(0.86)  LDD0963  [1]
 LDCM0366  AC99 HEK-293T C439(0.83); C782(1.31)  LDD0964  [1]
 LDCM0248  AKOS034007472 HEK-293T C439(1.65); C782(0.90)  LDD0846  [1]
 LDCM0356  AKOS034007680 HEK-293T C439(1.87); C782(0.49)  LDD0954  [1]
 LDCM0275  AKOS034007705 HEK-293T C439(1.47); C782(0.71)  LDD0873  [1]
 LDCM0367  CL1 HEK-293T C545(1.14)  LDD1571  [5]
 LDCM0369  CL100 HEK-293T C439(1.22); C782(0.75)  LDD0967  [1]
 LDCM0370  CL101 HEK-293T C439(1.38); C782(0.62)  LDD0968  [1]
 LDCM0371  CL102 HEK-293T C439(1.14); C782(0.53)  LDD0969  [1]
 LDCM0372  CL103 HEK-293T C439(1.36); C782(0.58)  LDD0970  [1]
 LDCM0373  CL104 HEK-293T C439(1.48); C782(0.68)  LDD0971  [1]
 LDCM0374  CL105 HEK-293T C782(0.89)  LDD0972  [1]
 LDCM0375  CL106 HEK-293T C782(0.71)  LDD0973  [1]
 LDCM0376  CL107 HEK-293T C782(0.94)  LDD0974  [1]
 LDCM0377  CL108 HEK-293T C782(0.77)  LDD0975  [1]
 LDCM0378  CL109 HEK-293T C782(0.76)  LDD0976  [1]
 LDCM0379  CL11 HEK-293T C545(1.21)  LDD1583  [5]
 LDCM0380  CL110 HEK-293T C782(0.77)  LDD0978  [1]
 LDCM0381  CL111 HEK-293T C782(1.03)  LDD0979  [1]
 LDCM0382  CL112 HEK-293T C439(1.07); C782(0.82)  LDD0980  [1]
 LDCM0383  CL113 HEK-293T C439(1.13); C782(1.10)  LDD0981  [1]
 LDCM0384  CL114 HEK-293T C439(1.47); C782(0.61)  LDD0982  [1]
 LDCM0385  CL115 HEK-293T C439(1.29); C782(0.78)  LDD0983  [1]
 LDCM0386  CL116 HEK-293T C439(1.30); C782(0.68)  LDD0984  [1]
 LDCM0387  CL117 PaTu 8988t C435(0.94); C439(0.94); C779(1.01); C782(1.01)  LDD1266  [1]
 LDCM0388  CL118 PaTu 8988t C435(1.05); C439(1.05); C779(1.28); C782(1.28)  LDD1267  [1]
 LDCM0389  CL119 PaTu 8988t C435(1.07); C439(1.07); C779(0.97); C782(0.97)  LDD1268  [1]
 LDCM0390  CL12 HEK-293T C545(1.02)  LDD1594  [5]
 LDCM0391  CL120 PaTu 8988t C435(0.93); C439(0.93); C779(1.10); C782(1.10)  LDD1270  [1]
 LDCM0392  CL121 HEK-293T C782(0.83)  LDD0990  [1]
 LDCM0393  CL122 HEK-293T C782(0.76)  LDD0991  [1]
 LDCM0394  CL123 HEK-293T C782(0.70)  LDD0992  [1]
 LDCM0395  CL124 HEK-293T C782(0.95)  LDD0993  [1]
 LDCM0396  CL125 HEK-293T C439(1.09)  LDD0994  [1]
 LDCM0397  CL126 HEK-293T C439(1.17)  LDD0995  [1]
 LDCM0398  CL127 HEK-293T C439(1.00)  LDD0996  [1]
 LDCM0399  CL128 HEK-293T C439(0.94)  LDD0997  [1]
 LDCM0400  CL13 HEK-293T C545(1.20)  LDD1604  [5]
 LDCM0401  CL14 HEK-293T C545(0.99)  LDD1605  [5]
 LDCM0402  CL15 HEK-293T C545(0.94); C681(1.33)  LDD1606  [5]
 LDCM0403  CL16 HEK-293T C439(1.19); C782(1.77)  LDD1001  [1]
 LDCM0404  CL17 HEK-293T C439(1.17); C782(1.00)  LDD1002  [1]
 LDCM0405  CL18 HEK-293T C439(1.21); C782(0.84)  LDD1003  [1]
 LDCM0406  CL19 HEK-293T C439(1.03); C782(0.92)  LDD1004  [1]
 LDCM0407  CL2 HEK-293T C545(0.90)  LDD1611  [5]
 LDCM0408  CL20 HEK-293T C439(1.11); C782(1.03)  LDD1006  [1]
 LDCM0409  CL21 HEK-293T C439(1.08); C782(0.81)  LDD1007  [1]
 LDCM0410  CL22 HEK-293T C439(1.16); C782(0.78)  LDD1008  [1]
 LDCM0411  CL23 HEK-293T C439(0.95); C782(0.94)  LDD1009  [1]
 LDCM0412  CL24 HEK-293T C439(1.17); C782(1.18)  LDD1010  [1]
 LDCM0413  CL25 HEK-293T C439(1.35); C782(0.78)  LDD1011  [1]
 LDCM0414  CL26 HEK-293T C439(1.08); C782(1.01)  LDD1012  [1]
 LDCM0415  CL27 HEK-293T C439(1.23); C782(0.84)  LDD1013  [1]
 LDCM0416  CL28 HEK-293T C439(0.97); C782(0.81)  LDD1014  [1]
 LDCM0417  CL29 HEK-293T C439(1.46); C782(1.08)  LDD1015  [1]
 LDCM0418  CL3 HEK-293T C545(1.06); C681(0.99)  LDD1622  [5]
 LDCM0419  CL30 HEK-293T C439(1.33); C782(0.84)  LDD1017  [1]
 LDCM0420  CL31 HEK-293T C782(1.55)  LDD1018  [1]
 LDCM0421  CL32 HEK-293T C782(1.33)  LDD1019  [1]
 LDCM0422  CL33 HEK-293T C782(0.88)  LDD1020  [1]
 LDCM0423  CL34 HEK-293T C782(1.05)  LDD1021  [1]
 LDCM0424  CL35 HEK-293T C782(1.14)  LDD1022  [1]
 LDCM0425  CL36 HEK-293T C782(0.97)  LDD1023  [1]
 LDCM0426  CL37 HEK-293T C782(1.17)  LDD1024  [1]
 LDCM0428  CL39 HEK-293T C782(0.67)  LDD1026  [1]
 LDCM0429  CL4 HEK-293T C545(0.93)  LDD1633  [5]
 LDCM0430  CL40 HEK-293T C782(0.91)  LDD1028  [1]
 LDCM0431  CL41 HEK-293T C782(0.66)  LDD1029  [1]
 LDCM0432  CL42 HEK-293T C782(0.58)  LDD1030  [1]
 LDCM0433  CL43 HEK-293T C782(0.59)  LDD1031  [1]
 LDCM0434  CL44 HEK-293T C782(1.07)  LDD1032  [1]
 LDCM0435  CL45 HEK-293T C782(0.65)  LDD1033  [1]
 LDCM0436  CL46 HEK-293T C782(1.11)  LDD1034  [1]
 LDCM0437  CL47 HEK-293T C782(0.98)  LDD1035  [1]
 LDCM0438  CL48 HEK-293T C782(1.26)  LDD1036  [1]
 LDCM0439  CL49 HEK-293T C782(0.97)  LDD1037  [1]
 LDCM0440  CL5 HEK-293T C545(1.03)  LDD1644  [5]
 LDCM0441  CL50 HEK-293T C782(0.74)  LDD1039  [1]
 LDCM0442  CL51 HEK-293T C782(0.78)  LDD1040  [1]
 LDCM0443  CL52 HEK-293T C782(1.29)  LDD1041  [1]
 LDCM0444  CL53 HEK-293T C782(1.14)  LDD1042  [1]
 LDCM0445  CL54 HEK-293T C782(0.81)  LDD1043  [1]
 LDCM0446  CL55 HEK-293T C782(1.00)  LDD1044  [1]
 LDCM0447  CL56 HEK-293T C782(0.98)  LDD1045  [1]
 LDCM0448  CL57 HEK-293T C782(1.02)  LDD1046  [1]
 LDCM0449  CL58 HEK-293T C782(0.97)  LDD1047  [1]
 LDCM0450  CL59 HEK-293T C782(0.85)  LDD1048  [1]
 LDCM0451  CL6 HEK-293T C545(0.66)  LDD1654  [5]
 LDCM0452  CL60 HEK-293T C782(0.84)  LDD1050  [1]
 LDCM0453  CL61 PaTu 8988t C435(1.01); C439(1.01)  LDD1332  [1]
 LDCM0454  CL62 PaTu 8988t C435(1.74); C439(1.74)  LDD1333  [1]
 LDCM0455  CL63 PaTu 8988t C435(1.11); C439(1.11)  LDD1334  [1]
 LDCM0456  CL64 PaTu 8988t C435(1.50); C439(1.50)  LDD1335  [1]
 LDCM0457  CL65 PaTu 8988t C435(0.81); C439(0.81)  LDD1336  [1]
 LDCM0458  CL66 PaTu 8988t C435(0.84); C439(0.84)  LDD1337  [1]
 LDCM0459  CL67 PaTu 8988t C435(1.32); C439(1.32)  LDD1338  [1]
 LDCM0460  CL68 PaTu 8988t C435(0.97); C439(0.97)  LDD1339  [1]
 LDCM0461  CL69 PaTu 8988t C435(0.89); C439(0.89)  LDD1340  [1]
 LDCM0462  CL7 HEK-293T C545(1.10); C681(1.00)  LDD1665  [5]
 LDCM0463  CL70 PaTu 8988t C435(1.02); C439(1.02)  LDD1342  [1]
 LDCM0464  CL71 PaTu 8988t C435(1.42); C439(1.42)  LDD1343  [1]
 LDCM0465  CL72 PaTu 8988t C435(1.34); C439(1.34)  LDD1344  [1]
 LDCM0466  CL73 PaTu 8988t C435(1.16); C439(1.16)  LDD1345  [1]
 LDCM0467  CL74 PaTu 8988t C435(1.06); C439(1.06)  LDD1346  [1]
 LDCM0469  CL76 HEK-293T C782(0.57)  LDD1067  [1]
 LDCM0470  CL77 HEK-293T C782(0.54)  LDD1068  [1]
 LDCM0471  CL78 HEK-293T C782(0.52)  LDD1069  [1]
 LDCM0472  CL79 HEK-293T C782(0.61)  LDD1070  [1]
 LDCM0473  CL8 HEK-293T C681(1.59)  LDD1676  [5]
 LDCM0474  CL80 HEK-293T C782(0.62)  LDD1072  [1]
 LDCM0475  CL81 HEK-293T C782(0.57)  LDD1073  [1]
 LDCM0476  CL82 HEK-293T C782(1.05)  LDD1074  [1]
 LDCM0477  CL83 HEK-293T C782(1.12)  LDD1075  [1]
 LDCM0478  CL84 HEK-293T C782(0.54)  LDD1076  [1]
 LDCM0479  CL85 HEK-293T C782(0.49)  LDD1077  [1]
 LDCM0480  CL86 HEK-293T C782(0.48)  LDD1078  [1]
 LDCM0481  CL87 HEK-293T C782(0.68)  LDD1079  [1]
 LDCM0482  CL88 HEK-293T C782(0.74)  LDD1080  [1]
 LDCM0483  CL89 HEK-293T C782(0.70)  LDD1081  [1]
 LDCM0484  CL9 HEK-293T C545(1.24)  LDD1687  [5]
 LDCM0485  CL90 HEK-293T C782(0.59)  LDD1083  [1]
 LDCM0486  CL91 HEK-293T C439(0.80); C782(1.47)  LDD1084  [1]
 LDCM0487  CL92 HEK-293T C439(1.16); C782(1.05)  LDD1085  [1]
 LDCM0488  CL93 HEK-293T C439(1.26); C782(1.10)  LDD1086  [1]
 LDCM0489  CL94 HEK-293T C439(1.33); C782(0.86)  LDD1087  [1]
 LDCM0490  CL95 HEK-293T C439(1.07); C782(0.66)  LDD1088  [1]
 LDCM0491  CL96 HEK-293T C439(1.06); C782(0.97)  LDD1089  [1]
 LDCM0492  CL97 HEK-293T C439(1.29); C782(1.19)  LDD1090  [1]
 LDCM0493  CL98 HEK-293T C439(1.04); C782(0.88)  LDD1091  [1]
 LDCM0494  CL99 HEK-293T C439(0.88); C782(0.94)  LDD1092  [1]
 LDCM0495  E2913 HEK-293T C545(1.08); C681(1.13)  LDD1698  [5]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C8(1.23)  LDD1702  [6]
 LDCM0468  Fragment33 PaTu 8988t C435(1.00); C439(1.00)  LDD1347  [1]
 LDCM0427  Fragment51 HEK-293T C782(1.16)  LDD1025  [1]
 LDCM0022  KB02 HCT 116 C681(2.27)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C681(1.28)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C681(2.05)  LDD0082  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
1-[2-deoxyribofuranosyl]-24-difluoro-5-methyl-benzene-5'monophosphate . DB07652
123-trihydroxy-1234-tetrahydrobenzo[A]Pyrene . DB07435
2'-deoxy-n-(Naphthalen-1-ylmethyl)Guanosine 5'-(Dihydrogen Phosphate) . DB08237

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761