Details of the Target

General Information of Target

Target ID LDTP13145
Target Name Glyoxylate reductase/hydroxypyruvate reductase (GRHPR)
Gene Name GRHPR
Gene ID 9380
Synonyms
GLXR; Glyoxylate reductase/hydroxypyruvate reductase; EC 1.1.1.79; EC 1.1.1.81
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRCCHICKLPGRVMGIRVLRLSLVVILVLLLVAGALTALLPSVKEDKMLMLRREIKSQGK
STMDSFTLIMQTYNRTDLLLKLLNHYQAVPNLHKVIVVWNNIGEKAPDELWNSLGPHPIP
VIFKQQTANRMRNRLQVFPELETNAVLMVDDDTLISTPDLVFAFSVWQQFPDQIVGFVPR
KHVSTSSGIYSYGSFEMQAPGSGNGDQYSMVLIGASFFNSKYLELFQRQPAAVHALIDDT
QNCDDIAMNFIIAKHIGKTSGIFVKPVNMDNLEKETNSGYSGMWHRAEHALQRSYCINKL
VNIYDSMPLRYSNIMISQFGFPYANYKRKI
Target Bioclass
Enzyme
Family
D-isomer specific 2-hydroxyacid dehydrogenase family
Function
Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate, oxidizes D-glycerate to hydroxypyruvate.
Uniprot ID
Q9UBQ7
Ensemble ID
ENST00000318158.11
HGNC ID
HGNC:4570
ChEMBL ID
CHEMBL4295972

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AU565 SNV: p.K134N .
CCSW1 SNV: p.E30K .
KNS81FD Deletion: p.S244del .
LOXIMVI SNV: p.E128K DBIA    Probe Info 
RKO SNV: p.A71T .
TOV21G SNV: p.R25L; p.E30Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.96  LDD0402  [1]
TH211
 Probe Info  		Y255(13.11)  LDD0260  [2]
STPyne
 Probe Info  		K233(7.07)  LDD0277  [3]
Probe 1
 Probe Info  		Y255(33.07)  LDD3495  [4]
DBIA
 Probe Info  		C123(0.84)  LDD3337  [5]
BTD
 Probe Info  		C288(1.63)  LDD2094  [6]
5E-2FA
 Probe Info  		N.A.  LDD2235  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C29(0.00); C57(0.00); C288(0.00); C147(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C29(0.00); C288(0.00)  LDD0032  [9]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [10]
Lodoacetamide azide
 Probe Info  		C29(0.00); C288(0.00); C147(0.00); C123(0.00)  LDD0037  [8]
IPM
 Probe Info  		N.A.  LDD0025  [11]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [11]
NAIA_4
 Probe Info  		N.A.  LDD2226  [12]
Compound 10
 Probe Info  		N.A.  LDD2216  [13]
Ox-W18
 Probe Info  		N.A.  LDD2175  [14]
1c-yne
 Probe Info  		N.A.  LDD0228  [15]
Acrolein
 Probe Info  		C29(0.00); C57(0.00)  LDD0217  [16]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [16]
Methacrolein
 Probe Info  		C29(0.00); C288(0.00)  LDD0218  [16]
AOyne
 Probe Info  		15.00  LDD0443  [17]
NAIA_5
 Probe Info  		C29(0.00); C57(0.00); C288(0.00); C123(0.00)  LDD2223  [12]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe14
 Probe Info  		12.61  LDD0477  [18]
FFF probe3
 Probe Info  		6.61  LDD0464  [18]
STS-2
 Probe Info  		N.A.  LDD0139  [19]
VE-P
 Probe Info  		N.A.  LDD0396  [20]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C29(0.96); C57(1.03); C147(0.99); C123(0.99)  LDD1507  [21]
 LDCM0215  AC10 HEK-293T C29(0.94); C57(1.06); C147(0.95); C216(0.99)  LDD1508  [21]
 LDCM0226  AC11 HEK-293T C29(1.00); C57(0.88); C147(1.04); C216(0.96)  LDD1509  [21]
 LDCM0237  AC12 HEK-293T C29(0.97); C57(0.83); C147(0.99); C216(1.00)  LDD1510  [21]
 LDCM0259  AC14 HEK-293T C29(1.10); C57(1.02); C147(1.03); C123(1.00)  LDD1512  [21]
 LDCM0270  AC15 HEK-293T C29(1.03); C57(0.92); C147(1.02)  LDD1513  [21]
 LDCM0276  AC17 HEK-293T C29(0.98); C57(0.92); C147(1.05); C123(1.14)  LDD1515  [21]
 LDCM0277  AC18 HEK-293T C29(0.94); C57(1.01); C147(0.87); C216(0.95)  LDD1516  [21]
 LDCM0278  AC19 HEK-293T C29(0.93); C57(0.84); C147(0.89); C216(0.96)  LDD1517  [21]
 LDCM0279  AC2 HEK-293T C29(1.08); C57(1.01); C147(0.99); C216(0.91)  LDD1518  [21]
 LDCM0280  AC20 HEK-293T C29(1.07); C57(0.88); C147(1.10); C216(1.00)  LDD1519  [21]
 LDCM0281  AC21 HEK-293T C29(1.01); C57(0.94); C147(1.03); C216(0.91)  LDD1520  [21]
 LDCM0282  AC22 HEK-293T C29(1.10); C57(1.10); C147(1.04); C123(0.96)  LDD1521  [21]
 LDCM0283  AC23 HEK-293T C29(0.96); C57(0.91); C147(1.17)  LDD1522  [21]
 LDCM0284  AC24 HEK-293T C29(1.06); C57(1.03); C147(1.04); C123(1.16)  LDD1523  [21]
 LDCM0285  AC25 HEK-293T C29(1.15); C57(0.98); C147(1.13); C123(1.00)  LDD1524  [21]
 LDCM0286  AC26 HEK-293T C29(1.05); C57(0.97); C147(0.89); C216(0.93)  LDD1525  [21]
 LDCM0287  AC27 HEK-293T C29(1.33); C57(0.96); C147(0.85); C216(1.12)  LDD1526  [21]
 LDCM0288  AC28 HEK-293T C29(1.09); C57(0.94); C147(1.06); C216(1.05)  LDD1527  [21]
 LDCM0289  AC29 HEK-293T C29(1.09); C57(1.02); C147(0.92); C216(1.03)  LDD1528  [21]
 LDCM0290  AC3 HEK-293T C29(1.19); C57(1.00); C147(0.93); C216(1.11)  LDD1529  [21]
 LDCM0291  AC30 HEK-293T C29(1.02); C57(0.98); C147(0.98); C123(0.85)  LDD1530  [21]
 LDCM0292  AC31 HEK-293T C29(1.14); C57(0.97); C147(1.01)  LDD1531  [21]
 LDCM0293  AC32 HEK-293T C29(1.00); C57(1.01); C147(1.07); C123(1.18)  LDD1532  [21]
 LDCM0294  AC33 HEK-293T C29(1.06); C57(0.92); C147(1.09); C123(1.35)  LDD1533  [21]
 LDCM0295  AC34 HEK-293T C29(0.99); C57(1.00); C147(0.99); C216(0.94)  LDD1534  [21]
 LDCM0296  AC35 HEK-293T C29(1.01); C57(0.99); C147(0.96); C216(1.05)  LDD1535  [21]
 LDCM0297  AC36 HEK-293T C29(1.04); C57(0.90); C147(1.15); C216(0.99)  LDD1536  [21]
 LDCM0298  AC37 HEK-293T C29(1.11); C57(0.98); C147(1.07); C216(0.83)  LDD1537  [21]
 LDCM0299  AC38 HEK-293T C29(1.06); C57(0.91); C147(1.05); C123(1.02)  LDD1538  [21]
 LDCM0300  AC39 HEK-293T C29(0.92); C57(0.99); C147(1.03)  LDD1539  [21]
 LDCM0301  AC4 HEK-293T C29(0.98); C57(0.89); C147(1.02); C216(0.96)  LDD1540  [21]
 LDCM0302  AC40 HEK-293T C29(1.13); C57(1.07); C147(1.19); C123(1.04)  LDD1541  [21]
 LDCM0303  AC41 HEK-293T C29(0.97); C57(0.93); C147(1.12); C123(1.24)  LDD1542  [21]
 LDCM0304  AC42 HEK-293T C29(0.92); C57(1.05); C147(0.95); C216(0.88)  LDD1543  [21]
 LDCM0305  AC43 HEK-293T C29(1.06); C57(0.92); C147(0.95); C216(1.02)  LDD1544  [21]
 LDCM0306  AC44 HEK-293T C29(1.11); C57(0.91); C147(1.06); C216(0.98)  LDD1545  [21]
 LDCM0307  AC45 HEK-293T C29(1.04); C57(0.91); C147(1.02); C216(0.97)  LDD1546  [21]
 LDCM0308  AC46 HEK-293T C147(1.11)  LDD0906  [22]
 LDCM0309  AC47 HEK-293T C147(1.39)  LDD0907  [22]
 LDCM0310  AC48 HEK-293T C147(1.20)  LDD0908  [22]
 LDCM0311  AC49 HEK-293T C147(1.22)  LDD0909  [22]
 LDCM0312  AC5 HEK-293T C29(1.09); C57(1.06); C147(0.99); C216(0.88)  LDD1551  [21]
 LDCM0313  AC50 HEK-293T C147(1.41)  LDD0911  [22]
 LDCM0314  AC51 HEK-293T C147(1.45)  LDD0912  [22]
 LDCM0315  AC52 HEK-293T C147(1.58)  LDD0913  [22]
 LDCM0316  AC53 HEK-293T C147(1.33)  LDD0914  [22]
 LDCM0317  AC54 HEK-293T C147(1.44)  LDD0915  [22]
 LDCM0318  AC55 HEK-293T C147(1.35)  LDD0916  [22]
 LDCM0319  AC56 HEK-293T C147(1.12)  LDD0917  [22]
 LDCM0320  AC57 HEK-293T C29(1.05); C57(0.88); C147(1.03); C123(1.15)  LDD1559  [21]
 LDCM0321  AC58 HEK-293T C29(0.92); C57(1.01); C147(1.00); C216(0.95)  LDD1560  [21]
 LDCM0322  AC59 HEK-293T C29(1.28); C57(0.93); C147(1.06); C216(1.01)  LDD1561  [21]
 LDCM0323  AC6 HEK-293T C29(1.15); C57(0.93); C147(0.92); C123(1.03)  LDD1562  [21]
 LDCM0324  AC60 HEK-293T C29(1.05); C57(0.93); C147(1.06); C216(0.96)  LDD1563  [21]
 LDCM0325  AC61 HEK-293T C29(1.06); C57(0.87); C147(1.04); C216(0.99)  LDD1564  [21]
 LDCM0326  AC62 HEK-293T C29(1.07); C57(0.85); C147(0.98); C123(0.98)  LDD1565  [21]
 LDCM0327  AC63 HEK-293T C29(1.08); C57(0.93); C147(0.95)  LDD1566  [21]
 LDCM0328  AC64 HEK-293T C29(1.02); C57(0.99); C147(1.06); C123(1.25)  LDD1567  [21]
 LDCM0334  AC7 HEK-293T C29(0.90); C57(0.93); C147(0.96)  LDD1568  [21]
 LDCM0345  AC8 HEK-293T C29(0.99); C57(1.03); C147(1.02); C123(1.07)  LDD1569  [21]
 LDCM0349  AC83 HEK-293T C147(0.96)  LDD0947  [22]
 LDCM0350  AC84 HEK-293T C147(1.11)  LDD0948  [22]
 LDCM0351  AC85 HEK-293T C147(1.04)  LDD0949  [22]
 LDCM0352  AC86 HEK-293T C147(0.92)  LDD0950  [22]
 LDCM0353  AC87 HEK-293T C147(1.03)  LDD0951  [22]
 LDCM0354  AC88 HEK-293T C147(1.17)  LDD0952  [22]
 LDCM0355  AC89 HEK-293T C147(1.36)  LDD0953  [22]
 LDCM0357  AC90 HEK-293T C147(1.38)  LDD0955  [22]
 LDCM0358  AC91 HEK-293T C147(1.27)  LDD0956  [22]
 LDCM0359  AC92 HEK-293T C147(1.29)  LDD0957  [22]
 LDCM0360  AC93 HEK-293T C147(1.09)  LDD0958  [22]
 LDCM0361  AC94 HEK-293T C147(1.05)  LDD0959  [22]
 LDCM0362  AC95 HEK-293T C147(0.99)  LDD0960  [22]
 LDCM0363  AC96 HEK-293T C147(1.05)  LDD0961  [22]
 LDCM0364  AC97 HEK-293T C147(2.27)  LDD0962  [22]
 LDCM0248  AKOS034007472 HEK-293T C29(1.10); C57(0.86); C147(1.01); C216(1.01)  LDD1511  [21]
 LDCM0356  AKOS034007680 HEK-293T C29(1.08); C57(0.92); C147(1.17); C123(0.91)  LDD1570  [21]
 LDCM0275  AKOS034007705 HEK-293T C29(1.05); C57(1.00); C147(1.19); C123(1.03)  LDD1514  [21]
 LDCM0156  Aniline NCI-H1299 12.10  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa C29(0.00); C57(0.00)  LDD0222  [16]
 LDCM0367  CL1 HEK-293T C29(1.06); C57(0.89); C147(1.04); C123(1.08)  LDD1571  [21]
 LDCM0368  CL10 HEK-293T C29(1.05); C57(1.16); C147(0.76); C123(0.71)  LDD1572  [21]
 LDCM0369  CL100 HEK-293T C29(0.90); C57(0.94); C147(0.92); C216(1.08)  LDD1573  [21]
 LDCM0370  CL101 HEK-293T C29(1.15); C57(0.90); C147(1.06); C123(1.00)  LDD1574  [21]
 LDCM0371  CL102 HEK-293T C29(1.04); C57(0.90); C147(0.96); C216(1.50)  LDD1575  [21]
 LDCM0372  CL103 HEK-293T C29(0.99); C57(0.82); C147(1.07); C123(0.95)  LDD1576  [21]
 LDCM0373  CL104 HEK-293T C29(0.97); C57(0.88); C147(1.00); C216(1.31)  LDD1577  [21]
 LDCM0374  CL105 HEK-293T C29(0.98); C57(0.87); C147(1.01); C123(1.10)  LDD1578  [21]
 LDCM0375  CL106 HEK-293T C29(1.04); C57(1.00); C147(1.01); C216(0.99)  LDD1579  [21]
 LDCM0376  CL107 HEK-293T C29(0.96); C57(0.98); C147(1.11); C123(0.88)  LDD1580  [21]
 LDCM0377  CL108 HEK-293T C29(0.92); C57(0.88); C147(0.92); C216(1.06)  LDD1581  [21]
 LDCM0378  CL109 HEK-293T C29(1.03); C57(0.98); C147(0.93); C123(0.86)  LDD1582  [21]
 LDCM0379  CL11 HEK-293T C29(1.11); C57(1.25); C147(0.73)  LDD1583  [21]
 LDCM0380  CL110 HEK-293T C29(1.20); C57(1.03); C147(0.88); C216(1.28)  LDD1584  [21]
 LDCM0381  CL111 HEK-293T C29(0.94); C57(0.92); C147(1.05); C123(0.81)  LDD1585  [21]
 LDCM0382  CL112 HEK-293T C29(0.94); C57(0.94); C147(1.01); C216(1.30)  LDD1586  [21]
 LDCM0383  CL113 HEK-293T C29(0.96); C57(0.98); C147(1.11); C123(1.07)  LDD1587  [21]
 LDCM0384  CL114 HEK-293T C29(1.17); C57(1.03); C147(1.09); C216(1.41)  LDD1588  [21]
 LDCM0385  CL115 HEK-293T C29(0.82); C57(1.03); C147(0.98); C123(0.99)  LDD1589  [21]
 LDCM0386  CL116 HEK-293T C29(0.98); C57(0.92); C147(1.03); C216(1.08)  LDD1590  [21]
 LDCM0387  CL117 HEK-293T C29(0.98); C57(1.07); C147(1.03); C123(1.14)  LDD1591  [21]
 LDCM0388  CL118 HEK-293T C29(0.99); C57(0.97); C147(1.02); C216(0.89)  LDD1592  [21]
 LDCM0389  CL119 HEK-293T C29(0.96); C57(0.94); C147(1.00); C123(1.00)  LDD1593  [21]
 LDCM0390  CL12 HEK-293T C29(0.97); C57(0.92); C147(1.06); C123(1.13)  LDD1594  [21]
 LDCM0391  CL120 HEK-293T C29(0.96); C57(0.99); C147(1.02); C216(1.08)  LDD1595  [21]
 LDCM0392  CL121 HEK-293T C147(1.55)  LDD0990  [22]
 LDCM0393  CL122 HEK-293T C147(1.17)  LDD0991  [22]
 LDCM0394  CL123 HEK-293T C147(1.55)  LDD0992  [22]
 LDCM0395  CL124 HEK-293T C147(1.17)  LDD0993  [22]
 LDCM0396  CL125 HEK-293T C29(0.89); C57(0.78); C147(1.37); C123(0.96)  LDD1600  [21]
 LDCM0397  CL126 HEK-293T C29(1.11); C57(0.79); C147(0.96); C216(1.12)  LDD1601  [21]
 LDCM0398  CL127 HEK-293T C29(1.10); C57(0.83); C147(0.92); C123(0.75)  LDD1602  [21]
 LDCM0399  CL128 HEK-293T C29(0.96); C57(0.86); C147(1.02); C216(0.99)  LDD1603  [21]
 LDCM0400  CL13 HEK-293T C29(0.83); C57(0.81); C147(1.07); C123(0.87)  LDD1604  [21]
 LDCM0401  CL14 HEK-293T C29(1.21); C57(0.89); C147(1.10); C216(1.12)  LDD1605  [21]
 LDCM0402  CL15 HEK-293T C29(1.13); C57(0.78); C147(0.95); C123(0.75)  LDD1606  [21]
 LDCM0403  CL16 HEK-293T C147(1.03)  LDD1001  [22]
 LDCM0404  CL17 HEK-293T C147(1.17)  LDD1002  [22]
 LDCM0405  CL18 HEK-293T C147(1.11)  LDD1003  [22]
 LDCM0406  CL19 HEK-293T C147(1.27)  LDD1004  [22]
 LDCM0407  CL2 HEK-293T C29(1.00); C57(0.93); C147(0.97); C216(1.05)  LDD1611  [21]
 LDCM0408  CL20 HEK-293T C147(1.04)  LDD1006  [22]
 LDCM0409  CL21 HEK-293T C147(1.50)  LDD1007  [22]
 LDCM0410  CL22 HEK-293T C147(1.19)  LDD1008  [22]
 LDCM0411  CL23 HEK-293T C147(1.03)  LDD1009  [22]
 LDCM0412  CL24 HEK-293T C147(0.99)  LDD1010  [22]
 LDCM0413  CL25 HEK-293T C147(1.12)  LDD1011  [22]
 LDCM0414  CL26 HEK-293T C147(1.19)  LDD1012  [22]
 LDCM0415  CL27 HEK-293T C147(1.38)  LDD1013  [22]
 LDCM0416  CL28 HEK-293T C147(1.17)  LDD1014  [22]
 LDCM0417  CL29 HEK-293T C147(1.01)  LDD1015  [22]
 LDCM0418  CL3 HEK-293T C29(1.00); C57(0.93); C147(1.07); C123(0.80)  LDD1622  [21]
 LDCM0419  CL30 HEK-293T C147(1.57)  LDD1017  [22]
 LDCM0420  CL31 HEK-293T C29(0.96); C57(0.75); C147(0.92); C216(1.31)  LDD1624  [21]
 LDCM0421  CL32 HEK-293T C29(0.99); C57(0.89); C147(0.93); C216(1.19)  LDD1625  [21]
 LDCM0422  CL33 HEK-293T C29(1.09); C57(0.94); C147(0.77); C216(1.26)  LDD1626  [21]
 LDCM0423  CL34 HEK-293T C29(1.06); C57(1.25); C147(0.81); C123(0.92)  LDD1627  [21]
 LDCM0424  CL35 HEK-293T C29(1.08); C57(1.14); C147(0.72)  LDD1628  [21]
 LDCM0425  CL36 HEK-293T C29(1.00); C57(0.97); C147(0.86); C123(1.19)  LDD1629  [21]
 LDCM0426  CL37 HEK-293T C29(1.07); C57(0.86); C147(1.02); C123(1.12)  LDD1630  [21]
 LDCM0428  CL39 HEK-293T C29(1.05); C57(0.88); C147(1.06); C123(0.70)  LDD1632  [21]
 LDCM0429  CL4 HEK-293T C29(0.93); C57(0.71); C147(0.87); C216(1.12)  LDD1633  [21]
 LDCM0430  CL40 HEK-293T C29(0.95); C57(0.88); C147(0.90); C216(1.09)  LDD1634  [21]
 LDCM0431  CL41 HEK-293T C29(1.02); C57(0.90); C147(1.04); C123(1.09)  LDD1635  [21]
 LDCM0432  CL42 HEK-293T C29(1.09); C57(0.83); C147(0.97); C216(0.98)  LDD1636  [21]
 LDCM0433  CL43 HEK-293T C29(1.30); C57(0.87); C147(0.91); C216(1.11)  LDD1637  [21]
 LDCM0434  CL44 HEK-293T C29(1.15); C57(0.90); C147(0.97); C216(1.29)  LDD1638  [21]
 LDCM0435  CL45 HEK-293T C29(0.95); C57(1.22); C147(0.81); C216(1.96)  LDD1639  [21]
 LDCM0436  CL46 HEK-293T C29(1.08); C57(1.34); C147(0.99); C123(1.03)  LDD1640  [21]
 LDCM0437  CL47 HEK-293T C29(1.27); C57(1.36); C147(0.72)  LDD1641  [21]
 LDCM0438  CL48 HEK-293T C29(1.06); C57(0.91); C147(0.96); C123(1.29)  LDD1642  [21]
 LDCM0439  CL49 HEK-293T C29(1.00); C57(0.85); C147(0.99); C123(1.13)  LDD1643  [21]
 LDCM0440  CL5 HEK-293T C29(1.23); C57(0.83); C147(0.92); C123(0.98)  LDD1644  [21]
 LDCM0441  CL50 HEK-293T C29(0.93); C57(0.91); C147(0.96); C216(1.08)  LDD1645  [21]
 LDCM0443  CL52 HEK-293T C29(1.01); C57(1.04); C147(0.93); C216(1.01)  LDD1646  [21]
 LDCM0444  CL53 HEK-293T C29(1.17); C57(0.88); C147(0.88); C123(0.92)  LDD1647  [21]
 LDCM0445  CL54 HEK-293T C29(0.94); C57(0.89); C147(0.90); C216(1.16)  LDD1648  [21]
 LDCM0446  CL55 HEK-293T C29(1.18); C57(0.83); C147(0.93); C216(1.21)  LDD1649  [21]
 LDCM0447  CL56 HEK-293T C29(0.74); C57(0.95); C147(0.90); C216(1.28)  LDD1650  [21]
 LDCM0448  CL57 HEK-293T C29(1.00); C57(1.10); C147(0.80); C216(2.99)  LDD1651  [21]
 LDCM0449  CL58 HEK-293T C29(1.09); C57(1.16); C147(1.00); C123(0.96)  LDD1652  [21]
 LDCM0450  CL59 HEK-293T C29(1.06); C57(1.46); C147(0.76)  LDD1653  [21]
 LDCM0451  CL6 HEK-293T C29(0.80); C57(0.82); C147(0.81); C216(1.30)  LDD1654  [21]
 LDCM0452  CL60 HEK-293T C29(0.98); C57(0.94); C147(1.00); C123(1.32)  LDD1655  [21]
 LDCM0453  CL61 HEK-293T C29(1.04); C57(0.86); C147(1.05); C123(1.09)  LDD1656  [21]
 LDCM0454  CL62 HEK-293T C29(1.05); C57(0.95); C147(1.06); C216(0.97)  LDD1657  [21]
 LDCM0455  CL63 HEK-293T C29(1.02); C57(0.92); C147(1.07); C123(1.10)  LDD1658  [21]
 LDCM0456  CL64 HEK-293T C29(0.97); C57(0.86); C147(0.93); C216(1.07)  LDD1659  [21]
 LDCM0457  CL65 HEK-293T C29(0.91); C57(0.93); C147(1.16); C123(0.97)  LDD1660  [21]
 LDCM0458  CL66 HEK-293T C29(0.89); C57(0.85); C147(0.86); C216(1.14)  LDD1661  [21]
 LDCM0459  CL67 HEK-293T C29(1.23); C57(0.85); C147(0.94); C216(1.06)  LDD1662  [21]
 LDCM0460  CL68 HEK-293T C29(1.07); C57(0.92); C147(0.90); C216(1.16)  LDD1663  [21]
 LDCM0461  CL69 HEK-293T C29(1.23); C57(1.11); C147(0.96); C216(0.95)  LDD1664  [21]
 LDCM0462  CL7 HEK-293T C29(1.00); C57(0.79); C147(0.94); C216(1.10)  LDD1665  [21]
 LDCM0463  CL70 HEK-293T C29(0.97); C57(1.26); C147(0.98); C123(1.08)  LDD1666  [21]
 LDCM0464  CL71 HEK-293T C29(1.02); C57(1.27); C147(0.96)  LDD1667  [21]
 LDCM0465  CL72 HEK-293T C29(0.93); C57(0.90); C147(0.99); C123(1.09)  LDD1668  [21]
 LDCM0466  CL73 HEK-293T C29(1.00); C57(0.93); C147(1.00); C123(0.92)  LDD1669  [21]
 LDCM0467  CL74 HEK-293T C29(1.15); C57(0.91); C147(1.04); C216(1.05)  LDD1670  [21]
 LDCM0469  CL76 HEK-293T C147(0.99)  LDD1067  [22]
 LDCM0470  CL77 HEK-293T C147(1.04)  LDD1068  [22]
 LDCM0471  CL78 HEK-293T C147(0.66)  LDD1069  [22]
 LDCM0472  CL79 HEK-293T C147(0.83)  LDD1070  [22]
 LDCM0473  CL8 HEK-293T C29(1.02); C57(0.75); C147(0.63); C216(2.90)  LDD1676  [21]
 LDCM0474  CL80 HEK-293T C147(0.74)  LDD1072  [22]
 LDCM0475  CL81 HEK-293T C147(0.91)  LDD1073  [22]
 LDCM0476  CL82 HEK-293T C147(1.05)  LDD1074  [22]
 LDCM0477  CL83 HEK-293T C147(1.10)  LDD1075  [22]
 LDCM0478  CL84 HEK-293T C147(0.76)  LDD1076  [22]
 LDCM0479  CL85 HEK-293T C147(0.89)  LDD1077  [22]
 LDCM0480  CL86 HEK-293T C147(0.81)  LDD1078  [22]
 LDCM0481  CL87 HEK-293T C147(0.98)  LDD1079  [22]
 LDCM0482  CL88 HEK-293T C147(1.06)  LDD1080  [22]
 LDCM0483  CL89 HEK-293T C147(0.93)  LDD1081  [22]
 LDCM0484  CL9 HEK-293T C29(0.95); C57(1.16); C147(0.88); C216(1.08)  LDD1687  [21]
 LDCM0485  CL90 HEK-293T C147(1.37)  LDD1083  [22]
 LDCM0486  CL91 HEK-293T C29(1.15); C57(0.78); C147(0.98); C216(1.10)  LDD1689  [21]
 LDCM0487  CL92 HEK-293T C29(0.97); C57(0.82); C147(0.95); C216(1.30)  LDD1690  [21]
 LDCM0488  CL93 HEK-293T C29(1.09); C57(1.08); C147(0.91); C216(1.06)  LDD1691  [21]
 LDCM0489  CL94 HEK-293T C29(1.01); C57(1.19); C147(0.99); C123(1.00)  LDD1692  [21]
 LDCM0490  CL95 HEK-293T C29(1.02); C57(1.01); C147(0.56)  LDD1693  [21]
 LDCM0491  CL96 HEK-293T C29(0.96); C57(0.90); C147(1.01); C123(1.05)  LDD1694  [21]
 LDCM0492  CL97 HEK-293T C29(0.97); C57(0.96); C147(0.91); C123(1.17)  LDD1695  [21]
 LDCM0493  CL98 HEK-293T C29(1.11); C57(1.02); C147(0.99); C216(1.03)  LDD1696  [21]
 LDCM0494  CL99 HEK-293T C29(1.06); C57(1.00); C147(0.97); C123(0.83)  LDD1697  [21]
 LDCM0495  E2913 HEK-293T C29(0.91); C57(0.92); C147(1.04); C123(1.03)  LDD1698  [21]
 LDCM0625  F8 Ramos C288(1.39); C29(0.91)  LDD2187  [23]
 LDCM0572  Fragment10 Ramos C288(0.91); C29(0.48)  LDD2189  [23]
 LDCM0573  Fragment11 Ramos C288(0.21); C29(0.44)  LDD2190  [23]
 LDCM0574  Fragment12 Ramos C288(0.65); C29(0.41)  LDD2191  [23]
 LDCM0575  Fragment13 Ramos C288(1.32); C29(0.88)  LDD2192  [23]
 LDCM0576  Fragment14 Ramos C288(1.14); C29(0.63)  LDD2193  [23]
 LDCM0579  Fragment20 Ramos C288(0.70); C29(0.35)  LDD2194  [23]
 LDCM0580  Fragment21 Ramos C288(0.69); C29(0.78)  LDD2195  [23]
 LDCM0582  Fragment23 Ramos C288(0.92); C29(0.66)  LDD2196  [23]
 LDCM0578  Fragment27 Ramos C288(1.59); C29(0.86)  LDD2197  [23]
 LDCM0586  Fragment28 Ramos C288(0.56); C29(0.88)  LDD2198  [23]
 LDCM0588  Fragment30 Ramos C288(1.45); C29(0.86)  LDD2199  [23]
 LDCM0589  Fragment31 Ramos C288(0.95); C29(0.91)  LDD2200  [23]
 LDCM0590  Fragment32 Ramos C288(0.75); C29(0.50)  LDD2201  [23]
 LDCM0468  Fragment33 HEK-293T C29(0.81); C57(0.95); C147(1.09); C123(1.19)  LDD1671  [21]
 LDCM0596  Fragment38 Ramos C288(2.02); C29(0.93)  LDD2203  [23]
 LDCM0566  Fragment4 Ramos C288(0.80); C29(0.77)  LDD2184  [23]
 LDCM0427  Fragment51 HEK-293T C29(1.17); C57(1.02); C147(1.00); C216(1.06)  LDD1631  [21]
 LDCM0610  Fragment52 Ramos C288(1.75); C29(1.00)  LDD2204  [23]
 LDCM0614  Fragment56 Ramos C288(1.18); C29(1.08)  LDD2205  [23]
 LDCM0569  Fragment7 Ramos C288(0.66); C29(0.51)  LDD2186  [23]
 LDCM0571  Fragment9 Ramos C288(0.74); C29(0.43)  LDD2188  [23]
 LDCM0107  IAA HeLa N.A.  LDD0221  [16]
 LDCM0022  KB02 HEK-293T C29(0.72); C57(1.16); C147(0.94)  LDD1492  [21]
 LDCM0023  KB03 HEK-293T C29(0.84); C57(1.03); C147(1.13)  LDD1497  [21]
 LDCM0024  KB05 MSTO-211H C123(0.84)  LDD3337  [5]
 LDCM0109  NEM HeLa C29(0.00); H280(0.00); H293(0.00); H87(0.00)  LDD0223  [16]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C288(1.63)  LDD2094  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C57(0.81)  LDD2123  [6]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C288(0.22)  LDD2149  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Solute carrier family 23 member 1 (SLC23A1) Nucleobase:cation symporter-2 (NCS2) family Q9UHI7

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
10 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
14 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
15 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
18 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
19 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
20 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
21 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
22 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
23 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578