Details of the Target

General Information of Target

Target ID LDTP13124
Target Name Methionine synthase reductase (MTRR)
Gene Name MTRR
Gene ID 4552
Synonyms
Methionine synthase reductase; MSR; EC 1.16.1.8; Aquacobalamin reductase; AqCbl reductase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MIHLGHILFLLLLPVAAAQTTPGERSSLPAFYPGTSGSCSGCGSLSLPLLAGLVAADAVA
SLLIVGAVFLCARPRRSPAQEDGKVYINMPGRG
Target Bioclass
Enzyme
Subcellular location
Cytoplasm
Function
Key enzyme in methionine and folate homeostasis responsible for the reactivation of methionine synthase (MTR/MS) activity by catalyzing the reductive methylation of MTR-bound cob(II)alamin. Cobalamin (vitamin B12) forms a complex with MTR to serve as an intermediary in methyl transfer reactions that cycles between MTR-bound methylcob(III)alamin and MTR bound-cob(I)alamin forms, and occasional oxidative escape of the cob(I)alamin intermediate during the catalytic cycle leads to the inactive cob(II)alamin species (Probable). The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine. Also necessary for the utilization of methyl groups from the folate cycle, thereby affecting transgenerational epigenetic inheritance. Also acts as a molecular chaperone for methionine synthase by stabilizing apoMTR and incorporating methylcob(III)alamin into apoMTR to form the holoenzyme. Also serves as an aquacob(III)alamin reductase by reducing aquacob(III)alamin to cob(II)alamin; this reduction leads to stimulation of the conversion of apoMTR and aquacob(III)alamin to MTR holoenzyme.
Uniprot ID
Q9UBK8
Ensemble ID
ENST00000264668.6
HGNC ID
HGNC:7473

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C-Sul
 Probe Info  		3.55  LDD0066  [1]
BTD
 Probe Info  		C455(1.12)  LDD2092  [2]
IPM
 Probe Info  		C340(2.04)  LDD1701  [2]
DBIA
 Probe Info  		C132(1.03)  LDD0078  [3]
5E-2FA
 Probe Info  		H566(0.00); H186(0.00); H632(0.00)  LDD2235  [4]
m-APA
 Probe Info  		H186(0.00); H566(0.00); H632(0.00)  LDD2231  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
TFBX
 Probe Info  		N.A.  LDD0148  [6]
Acrolein
 Probe Info  		H661(0.00); C340(0.00); C405(0.00)  LDD0217  [7]
Methacrolein
 Probe Info  		N.A.  LDD0218  [7]
AOyne
 Probe Info  		10.20  LDD0443  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C340(1.10)  LDD2152  [2]
 LDCM0214  AC1 HEK-293T C450(0.94)  LDD0812  [3]
 LDCM0215  AC10 HEK-293T C450(1.15)  LDD0813  [3]
 LDCM0216  AC100 HEK-293T C450(1.28)  LDD0814  [3]
 LDCM0217  AC101 HEK-293T C450(1.45)  LDD0815  [3]
 LDCM0218  AC102 HEK-293T C450(1.19)  LDD0816  [3]
 LDCM0219  AC103 HEK-293T C450(1.16)  LDD0817  [3]
 LDCM0220  AC104 HEK-293T C450(1.32)  LDD0818  [3]
 LDCM0221  AC105 HEK-293T C450(1.08)  LDD0819  [3]
 LDCM0222  AC106 HEK-293T C450(0.86)  LDD0820  [3]
 LDCM0223  AC107 HEK-293T C450(0.99)  LDD0821  [3]
 LDCM0224  AC108 HEK-293T C450(1.17)  LDD0822  [3]
 LDCM0225  AC109 HEK-293T C450(1.00)  LDD0823  [3]
 LDCM0226  AC11 HEK-293T C450(1.08)  LDD0824  [3]
 LDCM0227  AC110 HEK-293T C450(1.69)  LDD0825  [3]
 LDCM0228  AC111 HEK-293T C450(2.68)  LDD0826  [3]
 LDCM0229  AC112 HEK-293T C450(1.74)  LDD0827  [3]
 LDCM0230  AC113 HEK-293T C450(1.06)  LDD0828  [3]
 LDCM0231  AC114 HEK-293T C450(1.15)  LDD0829  [3]
 LDCM0232  AC115 HEK-293T C450(1.17)  LDD0830  [3]
 LDCM0233  AC116 HEK-293T C450(1.19)  LDD0831  [3]
 LDCM0234  AC117 HEK-293T C450(1.57)  LDD0832  [3]
 LDCM0235  AC118 HEK-293T C450(1.73)  LDD0833  [3]
 LDCM0236  AC119 HEK-293T C450(1.60)  LDD0834  [3]
 LDCM0237  AC12 HEK-293T C450(1.32)  LDD0835  [3]
 LDCM0238  AC120 HEK-293T C450(1.36)  LDD0836  [3]
 LDCM0239  AC121 HEK-293T C450(1.50)  LDD0837  [3]
 LDCM0240  AC122 HEK-293T C450(1.55)  LDD0838  [3]
 LDCM0241  AC123 HEK-293T C450(1.86)  LDD0839  [3]
 LDCM0242  AC124 HEK-293T C450(1.20)  LDD0840  [3]
 LDCM0243  AC125 HEK-293T C450(1.72)  LDD0841  [3]
 LDCM0244  AC126 HEK-293T C450(2.52)  LDD0842  [3]
 LDCM0245  AC127 HEK-293T C450(2.94)  LDD0843  [3]
 LDCM0246  AC128 HEK-293T C450(0.98)  LDD0844  [3]
 LDCM0247  AC129 HEK-293T C450(1.29)  LDD0845  [3]
 LDCM0249  AC130 HEK-293T C450(1.32)  LDD0847  [3]
 LDCM0250  AC131 HEK-293T C450(0.92)  LDD0848  [3]
 LDCM0251  AC132 HEK-293T C450(1.23)  LDD0849  [3]
 LDCM0252  AC133 HEK-293T C450(1.41)  LDD0850  [3]
 LDCM0253  AC134 HEK-293T C450(1.50)  LDD0851  [3]
 LDCM0254  AC135 HEK-293T C450(1.21)  LDD0852  [3]
 LDCM0255  AC136 HEK-293T C450(1.21)  LDD0853  [3]
 LDCM0256  AC137 HEK-293T C450(2.04)  LDD0854  [3]
 LDCM0257  AC138 HEK-293T C450(2.14)  LDD0855  [3]
 LDCM0258  AC139 HEK-293T C450(1.56)  LDD0856  [3]
 LDCM0259  AC14 HEK-293T C450(1.31)  LDD0857  [3]
 LDCM0260  AC140 HEK-293T C450(1.63)  LDD0858  [3]
 LDCM0261  AC141 HEK-293T C450(1.72)  LDD0859  [3]
 LDCM0262  AC142 HEK-293T C450(1.50)  LDD0860  [3]
 LDCM0270  AC15 HEK-293T C450(1.27)  LDD0868  [3]
 LDCM0276  AC17 HEK-293T C450(1.28)  LDD0874  [3]
 LDCM0277  AC18 HEK-293T C450(0.98)  LDD0875  [3]
 LDCM0278  AC19 HEK-293T C450(1.13)  LDD0876  [3]
 LDCM0279  AC2 HEK-293T C450(2.61)  LDD0877  [3]
 LDCM0280  AC20 HEK-293T C450(1.50)  LDD0878  [3]
 LDCM0281  AC21 HEK-293T C450(1.46)  LDD0879  [3]
 LDCM0282  AC22 HEK-293T C450(1.39)  LDD0880  [3]
 LDCM0283  AC23 HEK-293T C450(1.49)  LDD0881  [3]
 LDCM0284  AC24 HEK-293T C450(1.18)  LDD0882  [3]
 LDCM0285  AC25 HEK-293T C450(1.00)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C450(1.41)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C450(1.38)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C450(1.16)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C450(1.08)  LDD0887  [3]
 LDCM0290  AC3 HEK-293T C450(1.56)  LDD0888  [3]
 LDCM0291  AC30 HEK-293T C450(1.16)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C450(1.06)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C450(1.10)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C450(1.06)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C450(0.98)  LDD0893  [3]
 LDCM0296  AC35 HEK-293T C450(1.32)  LDD0894  [3]
 LDCM0297  AC36 HEK-293T C450(1.30)  LDD0895  [3]
 LDCM0298  AC37 HEK-293T C450(1.04)  LDD0896  [3]
 LDCM0299  AC38 HEK-293T C450(0.81)  LDD0897  [3]
 LDCM0300  AC39 HEK-293T C450(0.87)  LDD0898  [3]
 LDCM0301  AC4 HEK-293T C450(1.48)  LDD0899  [3]
 LDCM0302  AC40 HEK-293T C450(0.86)  LDD0900  [3]
 LDCM0303  AC41 HEK-293T C450(0.87)  LDD0901  [3]
 LDCM0304  AC42 HEK-293T C450(0.93)  LDD0902  [3]
 LDCM0305  AC43 HEK-293T C450(0.93)  LDD0903  [3]
 LDCM0306  AC44 HEK-293T C450(1.24)  LDD0904  [3]
 LDCM0307  AC45 HEK-293T C450(1.00)  LDD0905  [3]
 LDCM0308  AC46 PaTu 8988t C607(0.96)  LDD1187  [3]
 LDCM0309  AC47 PaTu 8988t C607(0.94)  LDD1188  [3]
 LDCM0310  AC48 PaTu 8988t C607(0.97)  LDD1189  [3]
 LDCM0311  AC49 PaTu 8988t C607(0.68)  LDD1190  [3]
 LDCM0312  AC5 HEK-293T C450(1.65)  LDD0910  [3]
 LDCM0313  AC50 PaTu 8988t C607(0.82)  LDD1192  [3]
 LDCM0314  AC51 PaTu 8988t C607(0.25)  LDD1193  [3]
 LDCM0315  AC52 PaTu 8988t C607(0.44)  LDD1194  [3]
 LDCM0316  AC53 PaTu 8988t C607(0.77)  LDD1195  [3]
 LDCM0317  AC54 PaTu 8988t C607(0.79)  LDD1196  [3]
 LDCM0318  AC55 PaTu 8988t C607(0.71)  LDD1197  [3]
 LDCM0319  AC56 PaTu 8988t C607(0.64)  LDD1198  [3]
 LDCM0320  AC57 HEK-293T C450(0.92)  LDD0918  [3]
 LDCM0321  AC58 HEK-293T C450(1.04)  LDD0919  [3]
 LDCM0322  AC59 HEK-293T C450(1.02)  LDD0920  [3]
 LDCM0323  AC6 HEK-293T C450(0.73)  LDD0921  [3]
 LDCM0324  AC60 HEK-293T C450(0.95)  LDD0922  [3]
 LDCM0325  AC61 HEK-293T C450(1.36)  LDD0923  [3]
 LDCM0326  AC62 HEK-293T C450(1.22)  LDD0924  [3]
 LDCM0327  AC63 HEK-293T C450(1.27)  LDD0925  [3]
 LDCM0328  AC64 HEK-293T C450(1.05)  LDD0926  [3]
 LDCM0329  AC65 HEK-293T C450(1.35)  LDD0927  [3]
 LDCM0330  AC66 HEK-293T C450(1.11)  LDD0928  [3]
 LDCM0331  AC67 HEK-293T C450(1.30)  LDD0929  [3]
 LDCM0332  AC68 HEK-293T C450(1.00)  LDD0930  [3]
 LDCM0333  AC69 HEK-293T C450(1.00)  LDD0931  [3]
 LDCM0334  AC7 HEK-293T C450(0.94)  LDD0932  [3]
 LDCM0335  AC70 HEK-293T C450(1.21)  LDD0933  [3]
 LDCM0336  AC71 HEK-293T C450(1.17)  LDD0934  [3]
 LDCM0337  AC72 HEK-293T C450(1.27)  LDD0935  [3]
 LDCM0338  AC73 HEK-293T C450(1.40)  LDD0936  [3]
 LDCM0339  AC74 HEK-293T C450(1.42)  LDD0937  [3]
 LDCM0340  AC75 HEK-293T C450(1.32)  LDD0938  [3]
 LDCM0341  AC76 HEK-293T C450(1.04)  LDD0939  [3]
 LDCM0342  AC77 HEK-293T C450(1.30)  LDD0940  [3]
 LDCM0343  AC78 HEK-293T C450(1.49)  LDD0941  [3]
 LDCM0344  AC79 HEK-293T C450(0.82)  LDD0942  [3]
 LDCM0345  AC8 HEK-293T C450(1.25)  LDD0943  [3]
 LDCM0346  AC80 HEK-293T C450(1.10)  LDD0944  [3]
 LDCM0347  AC81 HEK-293T C450(1.18)  LDD0945  [3]
 LDCM0348  AC82 HEK-293T C450(1.47)  LDD0946  [3]
 LDCM0349  AC83 HEK-293T C450(0.91)  LDD0947  [3]
 LDCM0350  AC84 HEK-293T C450(1.56)  LDD0948  [3]
 LDCM0351  AC85 HEK-293T C450(1.24)  LDD0949  [3]
 LDCM0352  AC86 HEK-293T C450(1.13)  LDD0950  [3]
 LDCM0353  AC87 HEK-293T C450(1.43)  LDD0951  [3]
 LDCM0354  AC88 HEK-293T C450(1.55)  LDD0952  [3]
 LDCM0355  AC89 HEK-293T C450(1.32)  LDD0953  [3]
 LDCM0357  AC90 HEK-293T C450(1.47)  LDD0955  [3]
 LDCM0358  AC91 HEK-293T C450(1.24)  LDD0956  [3]
 LDCM0359  AC92 HEK-293T C450(1.28)  LDD0957  [3]
 LDCM0360  AC93 HEK-293T C450(1.10)  LDD0958  [3]
 LDCM0361  AC94 HEK-293T C450(1.61)  LDD0959  [3]
 LDCM0362  AC95 HEK-293T C450(1.66)  LDD0960  [3]
 LDCM0363  AC96 HEK-293T C450(1.21)  LDD0961  [3]
 LDCM0364  AC97 HEK-293T C450(2.24)  LDD0962  [3]
 LDCM0365  AC98 HEK-293T C450(1.06)  LDD0963  [3]
 LDCM0366  AC99 HEK-293T C450(1.13)  LDD0964  [3]
 LDCM0248  AKOS034007472 HEK-293T C450(1.33)  LDD0846  [3]
 LDCM0356  AKOS034007680 HEK-293T C450(1.48)  LDD0954  [3]
 LDCM0275  AKOS034007705 HEK-293T C450(1.15)  LDD0873  [3]
 LDCM0020  ARS-1620 HCC44 C132(1.03)  LDD0078  [3]
 LDCM0108  Chloroacetamide HeLa H661(0.00); C405(0.00); C340(0.00)  LDD0222  [7]
 LDCM0367  CL1 HEK-293T C450(1.06)  LDD0965  [3]
 LDCM0368  CL10 HEK-293T C450(3.04)  LDD0966  [3]
 LDCM0369  CL100 HEK-293T C450(2.00)  LDD0967  [3]
 LDCM0370  CL101 HEK-293T C450(1.20)  LDD0968  [3]
 LDCM0371  CL102 HEK-293T C450(1.24)  LDD0969  [3]
 LDCM0372  CL103 HEK-293T C450(1.27)  LDD0970  [3]
 LDCM0373  CL104 HEK-293T C450(1.14)  LDD0971  [3]
 LDCM0374  CL105 HEK-293T C450(1.18)  LDD0972  [3]
 LDCM0375  CL106 HEK-293T C450(1.33)  LDD0973  [3]
 LDCM0376  CL107 HEK-293T C450(0.97)  LDD0974  [3]
 LDCM0377  CL108 HEK-293T C450(1.27)  LDD0975  [3]
 LDCM0378  CL109 HEK-293T C450(1.17)  LDD0976  [3]
 LDCM0379  CL11 HEK-293T C450(2.69)  LDD0977  [3]
 LDCM0380  CL110 HEK-293T C450(1.14)  LDD0978  [3]
 LDCM0381  CL111 HEK-293T C450(1.14)  LDD0979  [3]
 LDCM0382  CL112 HEK-293T C450(1.07)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C450(1.05)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C450(1.93)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C450(1.10)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C450(1.21)  LDD0984  [3]
 LDCM0387  CL117 HEK-293T C450(1.20)  LDD0985  [3]
 LDCM0388  CL118 HEK-293T C450(1.34)  LDD0986  [3]
 LDCM0389  CL119 HEK-293T C450(1.09)  LDD0987  [3]
 LDCM0390  CL12 HEK-293T C450(1.31)  LDD0988  [3]
 LDCM0391  CL120 HEK-293T C450(1.08)  LDD0989  [3]
 LDCM0392  CL121 PaTu 8988t C607(0.85)  LDD1271  [3]
 LDCM0393  CL122 PaTu 8988t C607(1.03)  LDD1272  [3]
 LDCM0394  CL123 PaTu 8988t C607(0.78)  LDD1273  [3]
 LDCM0395  CL124 PaTu 8988t C607(0.82)  LDD1274  [3]
 LDCM0396  CL125 HEK-293T C450(0.96)  LDD0994  [3]
 LDCM0397  CL126 HEK-293T C450(1.31)  LDD0995  [3]
 LDCM0398  CL127 HEK-293T C450(0.97)  LDD0996  [3]
 LDCM0399  CL128 HEK-293T C450(0.92)  LDD0997  [3]
 LDCM0400  CL13 HEK-293T C450(1.69)  LDD0998  [3]
 LDCM0401  CL14 HEK-293T C450(1.51)  LDD0999  [3]
 LDCM0402  CL15 HEK-293T C450(2.11)  LDD1000  [3]
 LDCM0403  CL16 HEK-293T C450(0.82)  LDD1001  [3]
 LDCM0404  CL17 HEK-293T C450(1.18)  LDD1002  [3]
 LDCM0405  CL18 HEK-293T C450(1.12)  LDD1003  [3]
 LDCM0406  CL19 HEK-293T C450(1.02)  LDD1004  [3]
 LDCM0407  CL2 HEK-293T C450(1.35)  LDD1005  [3]
 LDCM0408  CL20 HEK-293T C450(1.07)  LDD1006  [3]
 LDCM0409  CL21 HEK-293T C450(1.39)  LDD1007  [3]
 LDCM0410  CL22 HEK-293T C450(1.16)  LDD1008  [3]
 LDCM0411  CL23 HEK-293T C450(1.19)  LDD1009  [3]
 LDCM0412  CL24 HEK-293T C450(0.98)  LDD1010  [3]
 LDCM0413  CL25 HEK-293T C450(1.11)  LDD1011  [3]
 LDCM0414  CL26 HEK-293T C450(0.87)  LDD1012  [3]
 LDCM0415  CL27 HEK-293T C450(1.23)  LDD1013  [3]
 LDCM0416  CL28 HEK-293T C450(1.10)  LDD1014  [3]
 LDCM0417  CL29 HEK-293T C450(1.12)  LDD1015  [3]
 LDCM0418  CL3 HEK-293T C450(1.03)  LDD1016  [3]
 LDCM0419  CL30 HEK-293T C450(1.42)  LDD1017  [3]
 LDCM0420  CL31 HEK-293T C450(0.84)  LDD1018  [3]
 LDCM0421  CL32 HEK-293T C450(1.10)  LDD1019  [3]
 LDCM0422  CL33 HEK-293T C450(1.69)  LDD1020  [3]
 LDCM0423  CL34 HEK-293T C450(1.06)  LDD1021  [3]
 LDCM0424  CL35 HEK-293T C450(1.31)  LDD1022  [3]
 LDCM0425  CL36 HEK-293T C450(1.07)  LDD1023  [3]
 LDCM0426  CL37 HEK-293T C450(1.29)  LDD1024  [3]
 LDCM0428  CL39 HEK-293T C450(1.76)  LDD1026  [3]
 LDCM0429  CL4 HEK-293T C450(1.24)  LDD1027  [3]
 LDCM0430  CL40 HEK-293T C450(1.22)  LDD1028  [3]
 LDCM0431  CL41 HEK-293T C450(1.40)  LDD1029  [3]
 LDCM0432  CL42 HEK-293T C450(1.75)  LDD1030  [3]
 LDCM0433  CL43 HEK-293T C450(1.71)  LDD1031  [3]
 LDCM0434  CL44 HEK-293T C450(1.30)  LDD1032  [3]
 LDCM0435  CL45 HEK-293T C450(1.51)  LDD1033  [3]
 LDCM0437  CL47 HEK-293T C340(1.02)  LDD1641  [9]
 LDCM0438  CL48 HEK-293T C340(1.02)  LDD1642  [9]
 LDCM0439  CL49 HEK-293T C405(1.12); C37(1.41)  LDD1643  [9]
 LDCM0440  CL5 HEK-293T C450(1.45)  LDD1038  [3]
 LDCM0441  CL50 HEK-293T C405(1.26)  LDD1645  [9]
 LDCM0443  CL52 HEK-293T C405(1.14); C340(0.99)  LDD1646  [9]
 LDCM0444  CL53 HEK-293T C405(1.30)  LDD1647  [9]
 LDCM0445  CL54 HEK-293T C340(0.91)  LDD1648  [9]
 LDCM0446  CL55 HEK-293T C405(1.09); C340(0.96); C132(1.23)  LDD1649  [9]
 LDCM0447  CL56 HEK-293T C405(1.21)  LDD1650  [9]
 LDCM0448  CL57 HEK-293T C405(1.20)  LDD1651  [9]
 LDCM0450  CL59 HEK-293T C340(1.21)  LDD1653  [9]
 LDCM0451  CL6 HEK-293T C450(1.22)  LDD1049  [3]
 LDCM0452  CL60 HEK-293T C340(0.99)  LDD1655  [9]
 LDCM0453  CL61 PaTu 8988t C367(0.85); C607(0.80)  LDD1332  [3]
 LDCM0454  CL62 PaTu 8988t C367(1.17); C607(0.51)  LDD1333  [3]
 LDCM0455  CL63 PaTu 8988t C367(1.02); C607(0.40)  LDD1334  [3]
 LDCM0456  CL64 PaTu 8988t C367(0.88); C607(0.47)  LDD1335  [3]
 LDCM0457  CL65 PaTu 8988t C367(0.96); C607(0.53)  LDD1336  [3]
 LDCM0458  CL66 PaTu 8988t C367(0.98); C607(0.35)  LDD1337  [3]
 LDCM0459  CL67 PaTu 8988t C367(0.87); C607(0.48)  LDD1338  [3]
 LDCM0460  CL68 PaTu 8988t C367(0.81); C607(0.49)  LDD1339  [3]
 LDCM0461  CL69 PaTu 8988t C367(0.83); C607(0.56)  LDD1340  [3]
 LDCM0462  CL7 HEK-293T C450(1.45)  LDD1060  [3]
 LDCM0463  CL70 PaTu 8988t C367(0.89); C607(0.78)  LDD1342  [3]
 LDCM0464  CL71 PaTu 8988t C367(1.07); C607(0.84)  LDD1343  [3]
 LDCM0465  CL72 PaTu 8988t C367(1.06); C607(0.46)  LDD1344  [3]
 LDCM0466  CL73 PaTu 8988t C367(0.84); C607(0.35)  LDD1345  [3]
 LDCM0467  CL74 PaTu 8988t C367(0.73); C607(0.46)  LDD1346  [3]
 LDCM0469  CL76 PaTu 8988t C367(0.67); C607(0.75)  LDD1348  [3]
 LDCM0470  CL77 PaTu 8988t C367(0.82); C607(0.99)  LDD1349  [3]
 LDCM0471  CL78 PaTu 8988t C367(0.80); C607(0.86)  LDD1350  [3]
 LDCM0472  CL79 PaTu 8988t C367(0.94); C607(0.89)  LDD1351  [3]
 LDCM0473  CL8 HEK-293T C450(1.31)  LDD1071  [3]
 LDCM0474  CL80 PaTu 8988t C367(0.59); C607(0.75)  LDD1353  [3]
 LDCM0475  CL81 PaTu 8988t C367(0.76); C607(1.00)  LDD1354  [3]
 LDCM0476  CL82 PaTu 8988t C367(0.87); C607(1.17)  LDD1355  [3]
 LDCM0477  CL83 PaTu 8988t C367(0.74); C607(1.12)  LDD1356  [3]
 LDCM0478  CL84 PaTu 8988t C367(0.71); C607(0.93)  LDD1357  [3]
 LDCM0479  CL85 PaTu 8988t C367(0.84); C607(0.98)  LDD1358  [3]
 LDCM0480  CL86 PaTu 8988t C367(0.63); C607(0.78)  LDD1359  [3]
 LDCM0481  CL87 PaTu 8988t C367(0.67); C607(1.05)  LDD1360  [3]
 LDCM0482  CL88 PaTu 8988t C367(0.69); C607(0.85)  LDD1361  [3]
 LDCM0483  CL89 PaTu 8988t C367(0.73); C607(0.86)  LDD1362  [3]
 LDCM0484  CL9 HEK-293T C450(1.18)  LDD1082  [3]
 LDCM0485  CL90 PaTu 8988t C367(0.84); C607(0.97)  LDD1364  [3]
 LDCM0486  CL91 HEK-293T C450(1.33)  LDD1084  [3]
 LDCM0487  CL92 HEK-293T C450(1.63)  LDD1085  [3]
 LDCM0488  CL93 HEK-293T C450(1.42)  LDD1086  [3]
 LDCM0489  CL94 HEK-293T C450(1.43)  LDD1087  [3]
 LDCM0490  CL95 HEK-293T C450(2.76)  LDD1088  [3]
 LDCM0491  CL96 HEK-293T C450(1.75)  LDD1089  [3]
 LDCM0492  CL97 HEK-293T C450(1.78)  LDD1090  [3]
 LDCM0493  CL98 HEK-293T C450(1.40)  LDD1091  [3]
 LDCM0494  CL99 HEK-293T C450(2.26)  LDD1092  [3]
 LDCM0495  E2913 HEK-293T C405(1.17); C340(0.93)  LDD1698  [9]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C455(7.12); C340(2.03); C405(1.02)  LDD1702  [2]
 LDCM0468  Fragment33 PaTu 8988t C367(0.90); C607(0.34)  LDD1347  [3]
 LDCM0427  Fragment51 HEK-293T C450(1.35)  LDD1025  [3]
 LDCM0107  IAA HeLa N.A.  LDD0221  [7]
 LDCM0022  KB02 A2058 C432(2.31)  LDD2253  [10]
 LDCM0023  KB03 MDA-MB-231 C340(2.04)  LDD1701  [2]
 LDCM0024  KB05 MKN-1 C432(3.96); C132(2.66)  LDD3331  [10]
 LDCM0109  NEM HeLa H661(0.00); H632(0.00)  LDD0223  [7]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C455(1.12)  LDD2092  [2]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C455(0.81)  LDD2094  [2]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C455(1.14)  LDD2107  [2]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C405(1.94)  LDD2111  [2]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C455(1.33)  LDD2146  [2]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cyanocobalamin Small molecular drug DB00115
Methionine Small molecular drug DB00134

References

1 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840