Details of the Target

General Information of Target

Target ID LDTP13108
Target Name Serine/threonine-protein kinase NLK (NLK)
Gene Name NLK
Gene ID 51701
Synonyms
LAK1; Serine/threonine-protein kinase NLK; EC 2.7.11.24; Nemo-like kinase; Protein LAK1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV
KGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE
SFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTK
VAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDY
FLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMA
PVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPK
Target Bioclass
Enzyme
Family
Protein kinase superfamily, CMGC Ser/Thr protein kinase family, MAP kinase subfamily
Subcellular location
Nucleus
Function
Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Negative regulator of the canonical Wnt/beta-catenin signaling pathway. Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1. Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes. Negative regulator of the Notch signaling pathway. Binds to and phosphorylates NOTCH1, thereby preventing the formation of a transcriptionally active ternary complex of NOTCH1, RBPJ/RBPSUH and MAML1. Negative regulator of the MYB family of transcription factors. Phosphorylation of MYB leads to its subsequent proteolysis while phosphorylation of MYBL1 and MYBL2 inhibits their interaction with the coactivator CREBBP. Other transcription factors may also be inhibited by direct phosphorylation of CREBBP itself. Acts downstream of IL6 and MAP3K7/TAK1 to phosphorylate STAT3, which is in turn required for activation of NLK by MAP3K7/TAK1. Upon IL1B stimulus, cooperates with ATF5 to activate the transactivation activity of C/EBP subfamily members. Phosphorylates ATF5 but also stabilizes ATF5 protein levels in a kinase-independent manner. Acts as an inhibitor of the mTORC1 complex in response to osmotic stress by mediating phosphorylation of RPTOR, thereby preventing recruitment of the mTORC1 complex to lysosomes.
Uniprot ID
Q9UBE8
Ensemble ID
ENST00000407008.8
HGNC ID
HGNC:29858
ChEMBL ID
CHEMBL5364

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C281(0.88)  LDD1093  [1]
TFBX
 Probe Info  		C281(0.00); C497(0.00)  LDD0148  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C281(0.88)  LDD1093  [1]
 LDCM0215  AC10 PaTu 8988t C281(1.14)  LDD1094  [1]
 LDCM0216  AC100 PaTu 8988t C281(1.11)  LDD1095  [1]
 LDCM0217  AC101 PaTu 8988t C281(1.12)  LDD1096  [1]
 LDCM0218  AC102 PaTu 8988t C281(0.90)  LDD1097  [1]
 LDCM0219  AC103 PaTu 8988t C281(0.96)  LDD1098  [1]
 LDCM0220  AC104 PaTu 8988t C281(1.15)  LDD1099  [1]
 LDCM0221  AC105 PaTu 8988t C281(1.11)  LDD1100  [1]
 LDCM0222  AC106 PaTu 8988t C281(1.38)  LDD1101  [1]
 LDCM0223  AC107 PaTu 8988t C281(1.05)  LDD1102  [1]
 LDCM0224  AC108 PaTu 8988t C281(1.44)  LDD1103  [1]
 LDCM0225  AC109 PaTu 8988t C281(1.02)  LDD1104  [1]
 LDCM0226  AC11 PaTu 8988t C281(1.36)  LDD1105  [1]
 LDCM0227  AC110 PaTu 8988t C281(0.97)  LDD1106  [1]
 LDCM0228  AC111 PaTu 8988t C281(1.50)  LDD1107  [1]
 LDCM0229  AC112 PaTu 8988t C281(1.23)  LDD1108  [1]
 LDCM0230  AC113 PaTu 8988t C281(1.05)  LDD1109  [1]
 LDCM0231  AC114 PaTu 8988t C281(1.08)  LDD1110  [1]
 LDCM0232  AC115 PaTu 8988t C281(1.28)  LDD1111  [1]
 LDCM0233  AC116 PaTu 8988t C281(1.18)  LDD1112  [1]
 LDCM0234  AC117 PaTu 8988t C281(1.17)  LDD1113  [1]
 LDCM0235  AC118 PaTu 8988t C281(1.03)  LDD1114  [1]
 LDCM0236  AC119 PaTu 8988t C281(1.36)  LDD1115  [1]
 LDCM0237  AC12 PaTu 8988t C281(1.34)  LDD1116  [1]
 LDCM0238  AC120 PaTu 8988t C281(1.22)  LDD1117  [1]
 LDCM0239  AC121 PaTu 8988t C281(1.57)  LDD1118  [1]
 LDCM0240  AC122 PaTu 8988t C281(1.23)  LDD1119  [1]
 LDCM0241  AC123 PaTu 8988t C281(1.65)  LDD1120  [1]
 LDCM0242  AC124 PaTu 8988t C281(1.60)  LDD1121  [1]
 LDCM0243  AC125 PaTu 8988t C281(1.16)  LDD1122  [1]
 LDCM0244  AC126 PaTu 8988t C281(1.20)  LDD1123  [1]
 LDCM0245  AC127 PaTu 8988t C281(1.70)  LDD1124  [1]
 LDCM0246  AC128 PaTu 8988t C281(1.03)  LDD1125  [1]
 LDCM0247  AC129 PaTu 8988t C281(1.10)  LDD1126  [1]
 LDCM0249  AC130 PaTu 8988t C281(1.07)  LDD1128  [1]
 LDCM0250  AC131 PaTu 8988t C281(1.00)  LDD1129  [1]
 LDCM0251  AC132 PaTu 8988t C281(1.01)  LDD1130  [1]
 LDCM0252  AC133 PaTu 8988t C281(1.09)  LDD1131  [1]
 LDCM0253  AC134 PaTu 8988t C281(1.32)  LDD1132  [1]
 LDCM0254  AC135 PaTu 8988t C281(1.19)  LDD1133  [1]
 LDCM0255  AC136 PaTu 8988t C281(1.29)  LDD1134  [1]
 LDCM0256  AC137 PaTu 8988t C281(1.28)  LDD1135  [1]
 LDCM0257  AC138 PaTu 8988t C281(1.28)  LDD1136  [1]
 LDCM0258  AC139 PaTu 8988t C281(1.13)  LDD1137  [1]
 LDCM0259  AC14 PaTu 8988t C281(1.18)  LDD1138  [1]
 LDCM0260  AC140 PaTu 8988t C281(1.16)  LDD1139  [1]
 LDCM0261  AC141 PaTu 8988t C281(1.07)  LDD1140  [1]
 LDCM0262  AC142 PaTu 8988t C281(1.29)  LDD1141  [1]
 LDCM0263  AC143 PaTu 8988t C281(1.10)  LDD1142  [1]
 LDCM0264  AC144 PaTu 8988t C281(1.15)  LDD1143  [1]
 LDCM0265  AC145 PaTu 8988t C281(1.01)  LDD1144  [1]
 LDCM0266  AC146 PaTu 8988t C281(0.86)  LDD1145  [1]
 LDCM0267  AC147 PaTu 8988t C281(0.93)  LDD1146  [1]
 LDCM0268  AC148 PaTu 8988t C281(1.13)  LDD1147  [1]
 LDCM0269  AC149 PaTu 8988t C281(1.29)  LDD1148  [1]
 LDCM0270  AC15 PaTu 8988t C281(1.11)  LDD1149  [1]
 LDCM0271  AC150 PaTu 8988t C281(1.12)  LDD1150  [1]
 LDCM0272  AC151 PaTu 8988t C281(1.29)  LDD1151  [1]
 LDCM0273  AC152 PaTu 8988t C281(1.22)  LDD1152  [1]
 LDCM0274  AC153 PaTu 8988t C281(1.31)  LDD1153  [1]
 LDCM0621  AC154 PaTu 8988t C281(1.30)  LDD2166  [1]
 LDCM0622  AC155 PaTu 8988t C281(1.08)  LDD2167  [1]
 LDCM0623  AC156 PaTu 8988t C281(1.09)  LDD2168  [1]
 LDCM0624  AC157 PaTu 8988t C281(1.19)  LDD2169  [1]
 LDCM0276  AC17 PaTu 8988t C281(0.91)  LDD1155  [1]
 LDCM0277  AC18 PaTu 8988t C281(1.11)  LDD1156  [1]
 LDCM0278  AC19 PaTu 8988t C281(0.87)  LDD1157  [1]
 LDCM0279  AC2 PaTu 8988t C281(0.74)  LDD1158  [1]
 LDCM0280  AC20 PaTu 8988t C281(1.08)  LDD1159  [1]
 LDCM0281  AC21 PaTu 8988t C281(0.99)  LDD1160  [1]
 LDCM0282  AC22 PaTu 8988t C281(1.25)  LDD1161  [1]
 LDCM0283  AC23 PaTu 8988t C281(1.18)  LDD1162  [1]
 LDCM0284  AC24 PaTu 8988t C281(0.98)  LDD1163  [1]
 LDCM0285  AC25 PaTu 8988t C281(1.04)  LDD1164  [1]
 LDCM0286  AC26 PaTu 8988t C281(1.02)  LDD1165  [1]
 LDCM0287  AC27 PaTu 8988t C281(1.01)  LDD1166  [1]
 LDCM0288  AC28 PaTu 8988t C281(1.18)  LDD1167  [1]
 LDCM0289  AC29 PaTu 8988t C281(0.99)  LDD1168  [1]
 LDCM0290  AC3 PaTu 8988t C281(0.76)  LDD1169  [1]
 LDCM0291  AC30 PaTu 8988t C281(1.05)  LDD1170  [1]
 LDCM0292  AC31 PaTu 8988t C281(1.08)  LDD1171  [1]
 LDCM0293  AC32 PaTu 8988t C281(1.13)  LDD1172  [1]
 LDCM0294  AC33 PaTu 8988t C281(1.17)  LDD1173  [1]
 LDCM0295  AC34 PaTu 8988t C281(1.20)  LDD1174  [1]
 LDCM0296  AC35 PaTu 8988t C281(0.99)  LDD1175  [1]
 LDCM0297  AC36 PaTu 8988t C281(1.10)  LDD1176  [1]
 LDCM0298  AC37 PaTu 8988t C281(1.35)  LDD1177  [1]
 LDCM0299  AC38 PaTu 8988t C281(1.23)  LDD1178  [1]
 LDCM0300  AC39 PaTu 8988t C281(1.11)  LDD1179  [1]
 LDCM0301  AC4 PaTu 8988t C281(0.74)  LDD1180  [1]
 LDCM0302  AC40 PaTu 8988t C281(1.22)  LDD1181  [1]
 LDCM0303  AC41 PaTu 8988t C281(1.20)  LDD1182  [1]
 LDCM0304  AC42 PaTu 8988t C281(1.11)  LDD1183  [1]
 LDCM0305  AC43 PaTu 8988t C281(1.43)  LDD1184  [1]
 LDCM0306  AC44 PaTu 8988t C281(1.31)  LDD1185  [1]
 LDCM0307  AC45 PaTu 8988t C281(1.26)  LDD1186  [1]
 LDCM0308  AC46 PaTu 8988t C281(1.22)  LDD1187  [1]
 LDCM0309  AC47 PaTu 8988t C281(1.28)  LDD1188  [1]
 LDCM0310  AC48 PaTu 8988t C281(1.26)  LDD1189  [1]
 LDCM0311  AC49 PaTu 8988t C281(1.37)  LDD1190  [1]
 LDCM0312  AC5 PaTu 8988t C281(0.79)  LDD1191  [1]
 LDCM0313  AC50 PaTu 8988t C281(1.24)  LDD1192  [1]
 LDCM0314  AC51 PaTu 8988t C281(0.39)  LDD1193  [1]
 LDCM0315  AC52 PaTu 8988t C281(1.39)  LDD1194  [1]
 LDCM0316  AC53 PaTu 8988t C281(1.32)  LDD1195  [1]
 LDCM0317  AC54 PaTu 8988t C281(1.38)  LDD1196  [1]
 LDCM0318  AC55 PaTu 8988t C281(1.03)  LDD1197  [1]
 LDCM0319  AC56 PaTu 8988t C281(1.07)  LDD1198  [1]
 LDCM0320  AC57 PaTu 8988t C281(1.18)  LDD1199  [1]
 LDCM0321  AC58 PaTu 8988t C281(1.15)  LDD1200  [1]
 LDCM0322  AC59 PaTu 8988t C281(1.12)  LDD1201  [1]
 LDCM0323  AC6 PaTu 8988t C281(1.04)  LDD1202  [1]
 LDCM0324  AC60 PaTu 8988t C281(1.34)  LDD1203  [1]
 LDCM0325  AC61 PaTu 8988t C281(1.37)  LDD1204  [1]
 LDCM0326  AC62 PaTu 8988t C281(1.17)  LDD1205  [1]
 LDCM0327  AC63 PaTu 8988t C281(1.24)  LDD1206  [1]
 LDCM0328  AC64 PaTu 8988t C281(1.19)  LDD1207  [1]
 LDCM0329  AC65 PaTu 8988t C281(1.24)  LDD1208  [1]
 LDCM0330  AC66 PaTu 8988t C281(1.09)  LDD1209  [1]
 LDCM0331  AC67 PaTu 8988t C281(1.17)  LDD1210  [1]
 LDCM0332  AC68 PaTu 8988t C281(1.07)  LDD1211  [1]
 LDCM0333  AC69 PaTu 8988t C281(1.16)  LDD1212  [1]
 LDCM0334  AC7 PaTu 8988t C281(1.06)  LDD1213  [1]
 LDCM0335  AC70 PaTu 8988t C281(1.11)  LDD1214  [1]
 LDCM0336  AC71 PaTu 8988t C281(1.09)  LDD1215  [1]
 LDCM0337  AC72 PaTu 8988t C281(1.14)  LDD1216  [1]
 LDCM0338  AC73 PaTu 8988t C281(1.04)  LDD1217  [1]
 LDCM0339  AC74 PaTu 8988t C281(1.06)  LDD1218  [1]
 LDCM0340  AC75 PaTu 8988t C281(1.18)  LDD1219  [1]
 LDCM0341  AC76 PaTu 8988t C281(1.17)  LDD1220  [1]
 LDCM0342  AC77 PaTu 8988t C281(1.15)  LDD1221  [1]
 LDCM0343  AC78 PaTu 8988t C281(1.29)  LDD1222  [1]
 LDCM0344  AC79 PaTu 8988t C281(1.02)  LDD1223  [1]
 LDCM0345  AC8 PaTu 8988t C281(1.06)  LDD1224  [1]
 LDCM0346  AC80 PaTu 8988t C281(1.06)  LDD1225  [1]
 LDCM0347  AC81 PaTu 8988t C281(1.17)  LDD1226  [1]
 LDCM0348  AC82 PaTu 8988t C281(1.19)  LDD1227  [1]
 LDCM0365  AC98 PaTu 8988t C281(0.98)  LDD1244  [1]
 LDCM0366  AC99 PaTu 8988t C281(1.20)  LDD1245  [1]
 LDCM0248  AKOS034007472 PaTu 8988t C281(1.11)  LDD1127  [1]
 LDCM0356  AKOS034007680 PaTu 8988t C281(1.19)  LDD1235  [1]
 LDCM0275  AKOS034007705 PaTu 8988t C281(1.12)  LDD1154  [1]
 LDCM0367  CL1 PaTu 8988t C281(0.84)  LDD1246  [1]
 LDCM0368  CL10 PaTu 8988t C281(1.19)  LDD1247  [1]
 LDCM0369  CL100 PaTu 8988t C281(0.70)  LDD1248  [1]
 LDCM0370  CL101 PaTu 8988t C281(1.02)  LDD1249  [1]
 LDCM0371  CL102 PaTu 8988t C281(1.12)  LDD1250  [1]
 LDCM0372  CL103 PaTu 8988t C281(1.36)  LDD1251  [1]
 LDCM0373  CL104 PaTu 8988t C281(1.13)  LDD1252  [1]
 LDCM0374  CL105 PaTu 8988t C281(0.96)  LDD1253  [1]
 LDCM0375  CL106 PaTu 8988t C281(0.94)  LDD1254  [1]
 LDCM0376  CL107 PaTu 8988t C281(0.90)  LDD1255  [1]
 LDCM0377  CL108 PaTu 8988t C281(0.94)  LDD1256  [1]
 LDCM0378  CL109 PaTu 8988t C281(1.05)  LDD1257  [1]
 LDCM0379  CL11 PaTu 8988t C281(1.10)  LDD1258  [1]
 LDCM0380  CL110 PaTu 8988t C281(1.00)  LDD1259  [1]
 LDCM0381  CL111 PaTu 8988t C281(1.06)  LDD1260  [1]
 LDCM0382  CL112 PaTu 8988t C281(0.94)  LDD1261  [1]
 LDCM0383  CL113 PaTu 8988t C281(1.15)  LDD1262  [1]
 LDCM0384  CL114 PaTu 8988t C281(1.03)  LDD1263  [1]
 LDCM0385  CL115 PaTu 8988t C281(1.02)  LDD1264  [1]
 LDCM0386  CL116 PaTu 8988t C281(0.86)  LDD1265  [1]
 LDCM0387  CL117 PaTu 8988t C281(1.09)  LDD1266  [1]
 LDCM0388  CL118 PaTu 8988t C281(1.01)  LDD1267  [1]
 LDCM0389  CL119 PaTu 8988t C281(1.15)  LDD1268  [1]
 LDCM0390  CL12 PaTu 8988t C281(1.02)  LDD1269  [1]
 LDCM0391  CL120 PaTu 8988t C281(1.30)  LDD1270  [1]
 LDCM0392  CL121 PaTu 8988t C281(1.18)  LDD1271  [1]
 LDCM0393  CL122 PaTu 8988t C281(1.15)  LDD1272  [1]
 LDCM0394  CL123 PaTu 8988t C281(1.25)  LDD1273  [1]
 LDCM0395  CL124 PaTu 8988t C281(1.28)  LDD1274  [1]
 LDCM0396  CL125 PaTu 8988t C281(1.15)  LDD1275  [1]
 LDCM0397  CL126 PaTu 8988t C281(1.06)  LDD1276  [1]
 LDCM0398  CL127 PaTu 8988t C281(1.13)  LDD1277  [1]
 LDCM0399  CL128 PaTu 8988t C281(1.04)  LDD1278  [1]
 LDCM0400  CL13 PaTu 8988t C281(1.09)  LDD1279  [1]
 LDCM0401  CL14 PaTu 8988t C281(0.97)  LDD1280  [1]
 LDCM0402  CL15 PaTu 8988t C281(0.98)  LDD1281  [1]
 LDCM0403  CL16 PaTu 8988t C281(1.11)  LDD1282  [1]
 LDCM0404  CL17 PaTu 8988t C281(1.02)  LDD1283  [1]
 LDCM0405  CL18 PaTu 8988t C281(1.07)  LDD1284  [1]
 LDCM0406  CL19 PaTu 8988t C281(1.04)  LDD1285  [1]
 LDCM0407  CL2 PaTu 8988t C281(0.84)  LDD1286  [1]
 LDCM0408  CL20 PaTu 8988t C281(1.04)  LDD1287  [1]
 LDCM0409  CL21 PaTu 8988t C281(1.05)  LDD1288  [1]
 LDCM0410  CL22 PaTu 8988t C281(1.06)  LDD1289  [1]
 LDCM0411  CL23 PaTu 8988t C281(1.09)  LDD1290  [1]
 LDCM0412  CL24 PaTu 8988t C281(1.03)  LDD1291  [1]
 LDCM0413  CL25 PaTu 8988t C281(0.97)  LDD1292  [1]
 LDCM0414  CL26 PaTu 8988t C281(1.23)  LDD1293  [1]
 LDCM0415  CL27 PaTu 8988t C281(1.20)  LDD1294  [1]
 LDCM0416  CL28 PaTu 8988t C281(1.13)  LDD1295  [1]
 LDCM0417  CL29 PaTu 8988t C281(1.08)  LDD1296  [1]
 LDCM0418  CL3 PaTu 8988t C281(0.97)  LDD1297  [1]
 LDCM0419  CL30 PaTu 8988t C281(1.01)  LDD1298  [1]
 LDCM0420  CL31 PaTu 8988t C281(0.89)  LDD1299  [1]
 LDCM0421  CL32 PaTu 8988t C281(1.00)  LDD1300  [1]
 LDCM0422  CL33 PaTu 8988t C281(1.03)  LDD1301  [1]
 LDCM0423  CL34 PaTu 8988t C281(1.06)  LDD1302  [1]
 LDCM0424  CL35 PaTu 8988t C281(0.91)  LDD1303  [1]
 LDCM0425  CL36 PaTu 8988t C281(0.74)  LDD1304  [1]
 LDCM0426  CL37 PaTu 8988t C281(1.17)  LDD1305  [1]
 LDCM0428  CL39 PaTu 8988t C281(0.80)  LDD1307  [1]
 LDCM0429  CL4 PaTu 8988t C281(0.65)  LDD1308  [1]
 LDCM0430  CL40 PaTu 8988t C281(1.30)  LDD1309  [1]
 LDCM0431  CL41 PaTu 8988t C281(1.00)  LDD1310  [1]
 LDCM0432  CL42 PaTu 8988t C281(1.16)  LDD1311  [1]
 LDCM0433  CL43 PaTu 8988t C281(1.37)  LDD1312  [1]
 LDCM0434  CL44 PaTu 8988t C281(1.04)  LDD1313  [1]
 LDCM0435  CL45 PaTu 8988t C281(0.90)  LDD1314  [1]
 LDCM0436  CL46 PaTu 8988t C281(1.16)  LDD1315  [1]
 LDCM0437  CL47 PaTu 8988t C281(1.16)  LDD1316  [1]
 LDCM0438  CL48 PaTu 8988t C281(1.19)  LDD1317  [1]
 LDCM0439  CL49 PaTu 8988t C281(1.16)  LDD1318  [1]
 LDCM0440  CL5 PaTu 8988t C281(1.18)  LDD1319  [1]
 LDCM0441  CL50 PaTu 8988t C281(1.06)  LDD1320  [1]
 LDCM0442  CL51 PaTu 8988t C281(1.21)  LDD1321  [1]
 LDCM0443  CL52 PaTu 8988t C281(1.23)  LDD1322  [1]
 LDCM0444  CL53 PaTu 8988t C281(1.18)  LDD1323  [1]
 LDCM0445  CL54 PaTu 8988t C281(1.37)  LDD1324  [1]
 LDCM0446  CL55 PaTu 8988t C281(1.17)  LDD1325  [1]
 LDCM0447  CL56 PaTu 8988t C281(0.96)  LDD1326  [1]
 LDCM0448  CL57 PaTu 8988t C281(1.30)  LDD1327  [1]
 LDCM0449  CL58 PaTu 8988t C281(1.18)  LDD1328  [1]
 LDCM0450  CL59 PaTu 8988t C281(1.37)  LDD1329  [1]
 LDCM0451  CL6 PaTu 8988t C281(1.13)  LDD1330  [1]
 LDCM0452  CL60 PaTu 8988t C281(1.54)  LDD1331  [1]
 LDCM0453  CL61 PaTu 8988t C281(0.98)  LDD1332  [1]
 LDCM0454  CL62 PaTu 8988t C281(1.13)  LDD1333  [1]
 LDCM0455  CL63 PaTu 8988t C281(1.09)  LDD1334  [1]
 LDCM0456  CL64 PaTu 8988t C281(1.13)  LDD1335  [1]
 LDCM0457  CL65 PaTu 8988t C281(1.18)  LDD1336  [1]
 LDCM0458  CL66 PaTu 8988t C281(1.26)  LDD1337  [1]
 LDCM0459  CL67 PaTu 8988t C281(1.26)  LDD1338  [1]
 LDCM0460  CL68 PaTu 8988t C281(1.34)  LDD1339  [1]
 LDCM0461  CL69 PaTu 8988t C281(1.32)  LDD1340  [1]
 LDCM0462  CL7 PaTu 8988t C281(1.15)  LDD1341  [1]
 LDCM0463  CL70 PaTu 8988t C281(1.39)  LDD1342  [1]
 LDCM0464  CL71 PaTu 8988t C281(1.14)  LDD1343  [1]
 LDCM0465  CL72 PaTu 8988t C281(0.96)  LDD1344  [1]
 LDCM0466  CL73 PaTu 8988t C281(1.11)  LDD1345  [1]
 LDCM0467  CL74 PaTu 8988t C281(1.03)  LDD1346  [1]
 LDCM0469  CL76 PaTu 8988t C281(0.87)  LDD1348  [1]
 LDCM0470  CL77 PaTu 8988t C281(0.86)  LDD1349  [1]
 LDCM0471  CL78 PaTu 8988t C281(1.16)  LDD1350  [1]
 LDCM0472  CL79 PaTu 8988t C281(1.02)  LDD1351  [1]
 LDCM0473  CL8 PaTu 8988t C281(0.94)  LDD1352  [1]
 LDCM0474  CL80 PaTu 8988t C281(0.95)  LDD1353  [1]
 LDCM0475  CL81 PaTu 8988t C281(1.09)  LDD1354  [1]
 LDCM0476  CL82 PaTu 8988t C281(1.15)  LDD1355  [1]
 LDCM0477  CL83 PaTu 8988t C281(1.08)  LDD1356  [1]
 LDCM0478  CL84 PaTu 8988t C281(1.04)  LDD1357  [1]
 LDCM0479  CL85 PaTu 8988t C281(1.04)  LDD1358  [1]
 LDCM0480  CL86 PaTu 8988t C281(1.08)  LDD1359  [1]
 LDCM0481  CL87 PaTu 8988t C281(1.01)  LDD1360  [1]
 LDCM0482  CL88 PaTu 8988t C281(0.96)  LDD1361  [1]
 LDCM0483  CL89 PaTu 8988t C281(1.09)  LDD1362  [1]
 LDCM0484  CL9 PaTu 8988t C281(0.96)  LDD1363  [1]
 LDCM0485  CL90 PaTu 8988t C281(1.00)  LDD1364  [1]
 LDCM0486  CL91 PaTu 8988t C281(0.69)  LDD1365  [1]
 LDCM0487  CL92 PaTu 8988t C281(0.73)  LDD1366  [1]
 LDCM0488  CL93 PaTu 8988t C281(0.80)  LDD1367  [1]
 LDCM0489  CL94 PaTu 8988t C281(0.67)  LDD1368  [1]
 LDCM0490  CL95 PaTu 8988t C281(0.65)  LDD1369  [1]
 LDCM0491  CL96 PaTu 8988t C281(0.68)  LDD1370  [1]
 LDCM0492  CL97 PaTu 8988t C281(0.75)  LDD1371  [1]
 LDCM0493  CL98 PaTu 8988t C281(0.79)  LDD1372  [1]
 LDCM0494  CL99 PaTu 8988t C281(0.71)  LDD1373  [1]
 LDCM0468  Fragment33 PaTu 8988t C281(1.23)  LDD1347  [1]
 LDCM0427  Fragment51 PaTu 8988t C281(0.85)  LDD1306  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NADPH-dependent diflavin oxidoreductase 1 (NDOR1) NADPH-dependent diflavin oxidoreductase NDOR1 family; Flavodoxin family; Flavoprotein pyridine nucleotide cytochrome reductase family Q9UHB4
Death-associated protein kinase 3 (DAPK3) CAMK Ser/Thr protein kinase family O43293
RING finger and CHY zinc finger domain-containing protein 1 (RCHY1) . Q96PM5
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mothers against decapentaplegic homolog 4 (SMAD4) Dwarfin/SMAD family Q13485
Transcription factor Dp-1 (TFDP1) E2F/DP family Q14186
Zinc fingers and homeoboxes protein 3 (ZHX3) ZHX family Q9H4I2
Transcriptional regulator QRICH1 (QRICH1) . Q2TAL8
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
Progranulin (GRN) Granulin family P28799
Keratin-associated protein 4-2 (KRTAP4-2) KRTAP type 4 family Q9BYR5
Keratin-associated protein 5-6 (KRTAP5-6) KRTAP type 5 family Q6L8G9
Keratin-associated protein 5-9 (KRTAP5-9) KRTAP type 5 family P26371

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255