Details of the Target

General Information of Target

Target ID LDTP12949
Target Name COMM domain-containing protein 9 (COMMD9)
Gene Name COMMD9
Gene ID 29099
Synonyms
COMM domain-containing protein 9
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MNRLFGKAKPKAPPPSLTDCIGTVDSRAESIDKKISRLDAELVKYKDQIKKMREGPAKNM
VKQKALRVLKQKRMYEQQRDNLAQQSFNMEQANYTIQSLKDTKTTVDAMKLGVKEMKKAY
KQVKIDQIEDLQDQLEDMMEDANEIQEALSRSYGTPELDEDDLEAELDALGDELLADEDS
SYLDEAASAPAIPEGVPTDTKNKDGVLVDEFGLPQIPAS
Target Bioclass
Other
Subcellular location
Nucleus
Function
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B. Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits.
Uniprot ID
Q9P000
Ensemble ID
ENST00000263401.10
HGNC ID
HGNC:25014

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO320 SNV: p.T146P .
HT3 SNV: p.S119A .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K198(10.00); K21(5.88)  LDD0277  [1]
DBIA
 Probe Info  		C160(2.02)  LDD3332  [2]
AHL-Pu-1
 Probe Info  		C160(2.20)  LDD0171  [3]
IPM
 Probe Info  		C147(0.53)  LDD1701  [4]
Acrolein
 Probe Info  		N.A.  LDD0221  [5]
m-APA
 Probe Info  		N.A.  LDD2231  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0177  [7]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [8]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [9]
TFBX
 Probe Info  		N.A.  LDD0027  [9]
VSF
 Probe Info  		N.A.  LDD0007  [10]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [11]
1c-yne
 Probe Info  		N.A.  LDD0228  [12]
W1
 Probe Info  		C147(0.00); W128(0.00)  LDD0236  [13]
AOyne
 Probe Info  		15.00  LDD0443  [14]
NAIA_5
 Probe Info  		C160(0.00); C47(0.00); C147(0.00); C28(0.00)  LDD2223  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C160(2.20)  LDD0171  [3]
 LDCM0214  AC1 HEK-293T C47(1.08); C147(1.12)  LDD1507  [16]
 LDCM0215  AC10 HEK-293T C47(1.17); C160(1.10); C147(1.31)  LDD1508  [16]
 LDCM0226  AC11 HEK-293T C47(1.04); C147(1.06)  LDD1509  [16]
 LDCM0237  AC12 HEK-293T C47(1.06); C160(1.12); C147(1.19)  LDD1510  [16]
 LDCM0259  AC14 HEK-293T C47(1.07); C160(1.17); C147(1.20)  LDD1512  [16]
 LDCM0263  AC143 HEK-293T C147(0.91)  LDD0861  [17]
 LDCM0264  AC144 HEK-293T C147(0.79)  LDD0862  [17]
 LDCM0265  AC145 HEK-293T C147(0.97)  LDD0863  [17]
 LDCM0266  AC146 HEK-293T C147(0.94)  LDD0864  [17]
 LDCM0267  AC147 HEK-293T C147(0.89)  LDD0865  [17]
 LDCM0268  AC148 HEK-293T C147(1.15)  LDD0866  [17]
 LDCM0269  AC149 HEK-293T C147(0.82)  LDD0867  [17]
 LDCM0270  AC15 HEK-293T C47(1.11); C28(1.14); C160(1.22); C147(1.14)  LDD1513  [16]
 LDCM0271  AC150 HEK-293T C147(0.90)  LDD0869  [17]
 LDCM0272  AC151 HEK-293T C147(0.94)  LDD0870  [17]
 LDCM0273  AC152 HEK-293T C147(0.77)  LDD0871  [17]
 LDCM0274  AC153 HEK-293T C147(0.70)  LDD0872  [17]
 LDCM0621  AC154 HEK-293T C147(0.78)  LDD2162  [17]
 LDCM0622  AC155 HEK-293T C147(0.80)  LDD2163  [17]
 LDCM0623  AC156 HEK-293T C147(0.80)  LDD2164  [17]
 LDCM0624  AC157 HEK-293T C147(0.78)  LDD2165  [17]
 LDCM0276  AC17 HEK-293T C147(1.04)  LDD0874  [17]
 LDCM0277  AC18 HEK-293T C147(1.04)  LDD0875  [17]
 LDCM0278  AC19 HEK-293T C147(1.26)  LDD0876  [17]
 LDCM0279  AC2 HEK-293T C47(0.96); C160(1.04); C147(1.12)  LDD1518  [16]
 LDCM0280  AC20 HEK-293T C147(0.86)  LDD0878  [17]
 LDCM0281  AC21 HEK-293T C147(0.84)  LDD0879  [17]
 LDCM0282  AC22 HEK-293T C147(0.88)  LDD0880  [17]
 LDCM0283  AC23 HEK-293T C147(0.90)  LDD0881  [17]
 LDCM0284  AC24 HEK-293T C147(0.96)  LDD0882  [17]
 LDCM0285  AC25 HEK-293T C47(1.03); C147(1.13)  LDD1524  [16]
 LDCM0286  AC26 HEK-293T C47(0.93); C160(1.02); C147(1.07)  LDD1525  [16]
 LDCM0287  AC27 HEK-293T C47(1.01); C147(1.22)  LDD1526  [16]
 LDCM0288  AC28 HEK-293T C47(1.10); C160(1.09); C147(1.24)  LDD1527  [16]
 LDCM0289  AC29 HEK-293T C47(0.98); C160(1.10); C147(1.04)  LDD1528  [16]
 LDCM0290  AC3 HEK-293T C47(0.98); C147(1.21)  LDD1529  [16]
 LDCM0291  AC30 HEK-293T C47(0.97); C160(1.24); C147(1.36)  LDD1530  [16]
 LDCM0292  AC31 HEK-293T C47(1.16); C28(1.13); C160(1.24); C147(0.86)  LDD1531  [16]
 LDCM0293  AC32 HEK-293T C47(1.10); C160(1.41)  LDD1532  [16]
 LDCM0294  AC33 HEK-293T C47(1.00); C147(1.11)  LDD1533  [16]
 LDCM0295  AC34 HEK-293T C47(1.09); C160(1.21); C147(1.16)  LDD1534  [16]
 LDCM0296  AC35 HEK-293T C47(1.09); C147(1.23)  LDD1535  [16]
 LDCM0297  AC36 HEK-293T C47(1.25); C160(1.17); C147(1.21)  LDD1536  [16]
 LDCM0298  AC37 HEK-293T C47(1.22); C160(1.17); C147(1.46)  LDD1537  [16]
 LDCM0299  AC38 HEK-293T C47(0.95); C160(1.43); C147(1.45)  LDD1538  [16]
 LDCM0300  AC39 HEK-293T C47(1.14); C28(1.33); C160(1.34); C147(1.45)  LDD1539  [16]
 LDCM0301  AC4 HEK-293T C47(1.03); C160(1.06); C147(1.03)  LDD1540  [16]
 LDCM0302  AC40 HEK-293T C47(0.87); C160(1.28)  LDD1541  [16]
 LDCM0303  AC41 HEK-293T C47(1.37); C147(1.11)  LDD1542  [16]
 LDCM0304  AC42 HEK-293T C47(1.15); C160(1.24); C147(1.14)  LDD1543  [16]
 LDCM0305  AC43 HEK-293T C47(0.90); C147(1.12)  LDD1544  [16]
 LDCM0306  AC44 HEK-293T C47(1.13); C160(1.20); C147(1.12)  LDD1545  [16]
 LDCM0307  AC45 HEK-293T C47(1.25); C160(1.11); C147(1.25)  LDD1546  [16]
 LDCM0308  AC46 HEK-293T C47(0.93); C160(1.39); C147(1.17)  LDD1547  [16]
 LDCM0309  AC47 HEK-293T C47(1.07); C28(1.21); C160(1.25); C147(1.14)  LDD1548  [16]
 LDCM0310  AC48 HEK-293T C47(1.27); C160(1.23)  LDD1549  [16]
 LDCM0311  AC49 HEK-293T C47(1.22); C147(1.12)  LDD1550  [16]
 LDCM0312  AC5 HEK-293T C47(1.01); C160(1.12); C147(1.08)  LDD1551  [16]
 LDCM0313  AC50 HEK-293T C47(1.11); C160(1.10); C147(1.15)  LDD1552  [16]
 LDCM0314  AC51 HEK-293T C47(0.97); C147(1.16)  LDD1553  [16]
 LDCM0315  AC52 HEK-293T C47(1.04); C160(1.10); C147(1.36)  LDD1554  [16]
 LDCM0316  AC53 HEK-293T C47(1.17); C160(1.17); C147(1.21)  LDD1555  [16]
 LDCM0317  AC54 HEK-293T C47(0.98); C160(1.22); C147(1.59)  LDD1556  [16]
 LDCM0318  AC55 HEK-293T C47(1.24); C28(1.10); C160(1.28); C147(1.07)  LDD1557  [16]
 LDCM0319  AC56 HEK-293T C47(1.12); C160(1.04)  LDD1558  [16]
 LDCM0320  AC57 HEK-293T C147(1.05)  LDD0918  [17]
 LDCM0321  AC58 HEK-293T C147(1.09)  LDD0919  [17]
 LDCM0322  AC59 HEK-293T C147(1.11)  LDD0920  [17]
 LDCM0323  AC6 HEK-293T C47(0.91); C160(1.15); C147(1.16)  LDD1562  [16]
 LDCM0324  AC60 HEK-293T C147(1.09)  LDD0922  [17]
 LDCM0325  AC61 HEK-293T C147(0.84)  LDD0923  [17]
 LDCM0326  AC62 HEK-293T C147(0.68)  LDD0924  [17]
 LDCM0327  AC63 HEK-293T C147(0.75)  LDD0925  [17]
 LDCM0328  AC64 HEK-293T C147(0.80)  LDD0926  [17]
 LDCM0329  AC65 HEK-293T C147(0.67)  LDD0927  [17]
 LDCM0330  AC66 HEK-293T C147(0.91)  LDD0928  [17]
 LDCM0331  AC67 HEK-293T C147(0.90)  LDD0929  [17]
 LDCM0334  AC7 HEK-293T C47(1.03); C28(1.18); C160(1.20); C147(1.04)  LDD1568  [16]
 LDCM0345  AC8 HEK-293T C47(1.05); C160(0.89)  LDD1569  [16]
 LDCM0248  AKOS034007472 HEK-293T C47(1.10); C160(1.07); C147(1.12)  LDD1511  [16]
 LDCM0356  AKOS034007680 HEK-293T C47(1.18); C147(1.21)  LDD1570  [16]
 LDCM0275  AKOS034007705 HEK-293T C47(1.22); C160(1.42)  LDD1514  [16]
 LDCM0367  CL1 HEK-293T C47(1.18)  LDD1571  [16]
 LDCM0368  CL10 HEK-293T C47(0.83); C160(0.79); C147(1.35)  LDD1572  [16]
 LDCM0369  CL100 HEK-293T C47(1.09); C160(0.96)  LDD1573  [16]
 LDCM0370  CL101 HEK-293T C47(1.21)  LDD1574  [16]
 LDCM0371  CL102 HEK-293T C47(1.05); C28(1.09); C160(1.19); C147(1.20)  LDD1575  [16]
 LDCM0372  CL103 HEK-293T C47(0.94); C147(1.12)  LDD1576  [16]
 LDCM0373  CL104 HEK-293T C47(0.97); C160(0.96)  LDD1577  [16]
 LDCM0374  CL105 HEK-293T C147(1.03)  LDD0972  [17]
 LDCM0375  CL106 HEK-293T C147(0.94)  LDD0973  [17]
 LDCM0376  CL107 HEK-293T C147(1.06)  LDD0974  [17]
 LDCM0377  CL108 HEK-293T C147(1.03)  LDD0975  [17]
 LDCM0378  CL109 HEK-293T C147(0.91)  LDD0976  [17]
 LDCM0379  CL11 HEK-293T C47(1.20); C28(1.24); C160(0.94); C147(0.93)  LDD1583  [16]
 LDCM0380  CL110 HEK-293T C147(0.98)  LDD0978  [17]
 LDCM0381  CL111 HEK-293T C147(1.11)  LDD0979  [17]
 LDCM0382  CL112 HEK-293T C47(0.94); C160(1.04)  LDD1586  [16]
 LDCM0383  CL113 HEK-293T C47(1.18)  LDD1587  [16]
 LDCM0384  CL114 HEK-293T C47(1.07); C28(1.06); C160(1.35); C147(1.30)  LDD1588  [16]
 LDCM0385  CL115 HEK-293T C47(1.09); C147(1.18)  LDD1589  [16]
 LDCM0386  CL116 HEK-293T C47(1.10); C160(1.20)  LDD1590  [16]
 LDCM0387  CL117 HEK-293T C47(1.03)  LDD1591  [16]
 LDCM0388  CL118 HEK-293T C47(1.41); C28(1.03); C160(1.24); C147(1.04)  LDD1592  [16]
 LDCM0389  CL119 HEK-293T C47(1.40); C147(1.30)  LDD1593  [16]
 LDCM0390  CL12 HEK-293T C47(1.36); C160(1.14)  LDD1594  [16]
 LDCM0391  CL120 HEK-293T C47(1.16); C160(1.19)  LDD1595  [16]
 LDCM0392  CL121 HEK-293T C47(1.06)  LDD1596  [16]
 LDCM0393  CL122 HEK-293T C47(1.14); C28(1.12); C160(1.42); C147(1.08)  LDD1597  [16]
 LDCM0394  CL123 HEK-293T C47(1.07); C147(1.70)  LDD1598  [16]
 LDCM0395  CL124 HEK-293T C47(1.14); C160(1.19)  LDD1599  [16]
 LDCM0396  CL125 HEK-293T C147(1.05)  LDD0994  [17]
 LDCM0397  CL126 HEK-293T C147(1.08)  LDD0995  [17]
 LDCM0398  CL127 HEK-293T C147(0.98)  LDD0996  [17]
 LDCM0399  CL128 HEK-293T C147(1.07)  LDD0997  [17]
 LDCM0400  CL13 HEK-293T C47(1.05)  LDD1604  [16]
 LDCM0401  CL14 HEK-293T C47(1.18); C28(1.18); C160(0.98); C147(1.15)  LDD1605  [16]
 LDCM0402  CL15 HEK-293T C47(1.00); C147(1.12)  LDD1606  [16]
 LDCM0403  CL16 HEK-293T C147(0.90)  LDD1001  [17]
 LDCM0404  CL17 HEK-293T C147(0.93)  LDD1002  [17]
 LDCM0405  CL18 HEK-293T C147(0.86)  LDD1003  [17]
 LDCM0406  CL19 HEK-293T C147(0.94)  LDD1004  [17]
 LDCM0407  CL2 HEK-293T C47(1.06); C28(1.03); C160(1.03); C147(0.86)  LDD1611  [16]
 LDCM0408  CL20 HEK-293T C147(1.00)  LDD1006  [17]
 LDCM0409  CL21 HEK-293T C147(1.14)  LDD1007  [17]
 LDCM0410  CL22 HEK-293T C147(1.06)  LDD1008  [17]
 LDCM0411  CL23 HEK-293T C147(1.18)  LDD1009  [17]
 LDCM0412  CL24 HEK-293T C147(0.93)  LDD1010  [17]
 LDCM0413  CL25 HEK-293T C147(1.08)  LDD1011  [17]
 LDCM0414  CL26 HEK-293T C147(1.17)  LDD1012  [17]
 LDCM0415  CL27 HEK-293T C147(0.84)  LDD1013  [17]
 LDCM0416  CL28 HEK-293T C147(1.09)  LDD1014  [17]
 LDCM0417  CL29 HEK-293T C147(1.02)  LDD1015  [17]
 LDCM0418  CL3 HEK-293T C47(0.97); C147(1.19)  LDD1622  [16]
 LDCM0419  CL30 HEK-293T C147(1.06)  LDD1017  [17]
 LDCM0420  CL31 HEK-293T C47(0.97); C147(0.92)  LDD1624  [16]
 LDCM0421  CL32 HEK-293T C47(1.08); C160(0.95); C147(0.98)  LDD1625  [16]
 LDCM0422  CL33 HEK-293T C47(0.90); C160(0.87); C147(1.30)  LDD1626  [16]
 LDCM0423  CL34 HEK-293T C47(1.10); C160(0.98); C147(1.34)  LDD1627  [16]
 LDCM0424  CL35 HEK-293T C47(1.24); C28(1.25); C160(1.15); C147(1.33)  LDD1628  [16]
 LDCM0425  CL36 HEK-293T C47(1.33); C160(1.09)  LDD1629  [16]
 LDCM0426  CL37 HEK-293T C47(1.22)  LDD1630  [16]
 LDCM0428  CL39 HEK-293T C47(0.84); C147(1.00)  LDD1632  [16]
 LDCM0429  CL4 HEK-293T C47(1.11); C160(0.87)  LDD1633  [16]
 LDCM0430  CL40 HEK-293T C47(1.04); C160(1.01)  LDD1634  [16]
 LDCM0431  CL41 HEK-293T C47(1.07); C147(1.27)  LDD1635  [16]
 LDCM0432  CL42 HEK-293T C47(0.97); C160(1.03); C147(1.06)  LDD1636  [16]
 LDCM0433  CL43 HEK-293T C47(0.83); C147(1.14)  LDD1637  [16]
 LDCM0434  CL44 HEK-293T C47(0.86); C160(1.10); C147(1.21)  LDD1638  [16]
 LDCM0435  CL45 HEK-293T C47(0.97); C160(0.92); C147(1.28)  LDD1639  [16]
 LDCM0436  CL46 HEK-293T C47(1.08); C160(1.12); C147(1.50)  LDD1640  [16]
 LDCM0437  CL47 HEK-293T C47(1.25); C28(1.31); C160(1.23); C147(1.12)  LDD1641  [16]
 LDCM0438  CL48 HEK-293T C47(1.13); C160(1.17)  LDD1642  [16]
 LDCM0439  CL49 HEK-293T C47(1.16)  LDD1643  [16]
 LDCM0440  CL5 HEK-293T C47(1.25); C147(1.08)  LDD1644  [16]
 LDCM0441  CL50 HEK-293T C47(1.02); C28(1.09); C160(1.00); C147(1.25)  LDD1645  [16]
 LDCM0443  CL52 HEK-293T C47(1.05); C160(1.03)  LDD1646  [16]
 LDCM0444  CL53 HEK-293T C47(0.94); C147(1.33)  LDD1647  [16]
 LDCM0445  CL54 HEK-293T C47(1.08); C160(1.03); C147(1.33)  LDD1648  [16]
 LDCM0446  CL55 HEK-293T C47(0.99); C147(1.04)  LDD1649  [16]
 LDCM0447  CL56 HEK-293T C47(1.05); C160(1.09); C147(1.23)  LDD1650  [16]
 LDCM0448  CL57 HEK-293T C47(1.19); C160(0.91); C147(1.15)  LDD1651  [16]
 LDCM0449  CL58 HEK-293T C47(1.12); C160(1.18); C147(1.47)  LDD1652  [16]
 LDCM0450  CL59 HEK-293T C47(1.45); C28(1.35); C160(1.18); C147(1.31)  LDD1653  [16]
 LDCM0451  CL6 HEK-293T C47(1.02); C160(0.98); C147(1.09)  LDD1654  [16]
 LDCM0452  CL60 HEK-293T C47(1.10); C160(1.14)  LDD1655  [16]
 LDCM0453  CL61 HEK-293T C47(1.31)  LDD1656  [16]
 LDCM0454  CL62 HEK-293T C47(1.18); C28(1.14); C160(0.97); C147(1.30)  LDD1657  [16]
 LDCM0455  CL63 HEK-293T C47(1.22); C147(1.29)  LDD1658  [16]
 LDCM0456  CL64 HEK-293T C47(1.03); C160(1.02)  LDD1659  [16]
 LDCM0457  CL65 HEK-293T C47(1.30); C147(1.06)  LDD1660  [16]
 LDCM0458  CL66 HEK-293T C47(1.13); C160(1.14); C147(1.16)  LDD1661  [16]
 LDCM0459  CL67 HEK-293T C47(1.11); C147(1.29)  LDD1662  [16]
 LDCM0460  CL68 HEK-293T C47(1.10); C160(1.13); C147(1.12)  LDD1663  [16]
 LDCM0461  CL69 HEK-293T C47(1.25); C160(1.02); C147(1.27)  LDD1664  [16]
 LDCM0462  CL7 HEK-293T C47(1.01); C147(1.17)  LDD1665  [16]
 LDCM0463  CL70 HEK-293T C47(1.05); C160(1.16); C147(1.40)  LDD1666  [16]
 LDCM0464  CL71 HEK-293T C47(1.20); C28(1.44); C160(1.19); C147(0.99)  LDD1667  [16]
 LDCM0465  CL72 HEK-293T C47(1.50); C160(1.15)  LDD1668  [16]
 LDCM0466  CL73 HEK-293T C47(0.98)  LDD1669  [16]
 LDCM0467  CL74 HEK-293T C47(0.92); C28(1.01); C160(1.05); C147(1.01)  LDD1670  [16]
 LDCM0469  CL76 HEK-293T C147(0.86)  LDD1067  [17]
 LDCM0470  CL77 HEK-293T C147(1.09)  LDD1068  [17]
 LDCM0471  CL78 HEK-293T C147(0.87)  LDD1069  [17]
 LDCM0472  CL79 HEK-293T C147(0.85)  LDD1070  [17]
 LDCM0473  CL8 HEK-293T C47(1.00); C160(0.93); C147(1.86)  LDD1676  [16]
 LDCM0474  CL80 HEK-293T C147(0.83)  LDD1072  [17]
 LDCM0475  CL81 HEK-293T C147(0.88)  LDD1073  [17]
 LDCM0476  CL82 HEK-293T C147(0.93)  LDD1074  [17]
 LDCM0477  CL83 HEK-293T C147(0.94)  LDD1075  [17]
 LDCM0478  CL84 HEK-293T C147(1.01)  LDD1076  [17]
 LDCM0479  CL85 HEK-293T C147(0.98)  LDD1077  [17]
 LDCM0480  CL86 HEK-293T C147(0.91)  LDD1078  [17]
 LDCM0481  CL87 HEK-293T C147(0.86)  LDD1079  [17]
 LDCM0482  CL88 HEK-293T C147(1.00)  LDD1080  [17]
 LDCM0483  CL89 HEK-293T C147(0.80)  LDD1081  [17]
 LDCM0484  CL9 HEK-293T C47(1.35); C160(0.91); C147(0.89)  LDD1687  [16]
 LDCM0485  CL90 HEK-293T C147(0.98)  LDD1083  [17]
 LDCM0486  CL91 HEK-293T C47(1.08); C147(1.05)  LDD1689  [16]
 LDCM0487  CL92 HEK-293T C47(1.25); C160(1.17); C147(1.18)  LDD1690  [16]
 LDCM0488  CL93 HEK-293T C47(1.05); C160(1.00); C147(1.12)  LDD1691  [16]
 LDCM0489  CL94 HEK-293T C47(0.98); C160(1.25); C147(1.16)  LDD1692  [16]
 LDCM0490  CL95 HEK-293T C47(1.16); C28(1.23); C160(1.11); C147(1.35)  LDD1693  [16]
 LDCM0491  CL96 HEK-293T C47(1.15); C160(1.22)  LDD1694  [16]
 LDCM0492  CL97 HEK-293T C47(1.08)  LDD1695  [16]
 LDCM0493  CL98 HEK-293T C47(1.16); C28(1.05); C160(1.07); C147(1.03)  LDD1696  [16]
 LDCM0494  CL99 HEK-293T C47(1.06); C147(1.27)  LDD1697  [16]
 LDCM0495  E2913 HEK-293T C47(1.02); C147(1.06)  LDD1698  [16]
 LDCM0625  F8 Ramos C147(1.08)  LDD2187  [18]
 LDCM0574  Fragment12 Ramos C147(0.93)  LDD2191  [18]
 LDCM0579  Fragment20 Ramos C147(1.26)  LDD2194  [18]
 LDCM0580  Fragment21 Ramos C147(1.03)  LDD2195  [18]
 LDCM0582  Fragment23 Ramos C147(0.55)  LDD2196  [18]
 LDCM0578  Fragment27 Ramos C147(1.18)  LDD2197  [18]
 LDCM0586  Fragment28 Ramos C147(0.94)  LDD2198  [18]
 LDCM0589  Fragment31 Ramos C147(1.43)  LDD2200  [18]
 LDCM0590  Fragment32 Ramos C147(1.01)  LDD2201  [18]
 LDCM0468  Fragment33 HEK-293T C47(1.12); C147(1.26)  LDD1671  [16]
 LDCM0596  Fragment38 Ramos C147(1.01)  LDD2203  [18]
 LDCM0427  Fragment51 HEK-293T C47(1.16); C28(1.09); C160(1.21); C147(1.06)  LDD1631  [16]
 LDCM0569  Fragment7 Ramos C147(1.39)  LDD2186  [18]
 LDCM0107  IAA HeLa N.A.  LDD0221  [5]
 LDCM0022  KB02 HEK-293T C160(1.03); C47(1.19)  LDD1492  [16]
 LDCM0023  KB03 HEK-293T C160(1.09); C47(1.09)  LDD1497  [16]
 LDCM0024  KB05 MKN45 C160(2.02)  LDD3332  [2]
 LDCM0109  NEM HeLa N.A.  LDD0223  [5]
 LDCM0627  NUDT7-COV-1 HEK-293T C28(1.70)  LDD2206  [19]
 LDCM0628  OTUB2-COV-1 HEK-293T C147(0.45)  LDD2207  [19]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Coiled-coil domain-containing protein 22 (CCDC22) CCDC22 family O60826
Coiled-coil domain-containing protein 93 (CCDC93) CCDC93 family Q567U6
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
COMM domain-containing protein 6 (COMMD6) . Q7Z4G1
Doublecortin domain-containing protein 2 (DCDC2) . Q9UHG0

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
13 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
17 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
18 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
19 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.