Details of the Target

General Information of Target

Target ID LDTP12556
Target Name Ras association domain-containing protein 1 (RASSF1)
Gene Name RASSF1
Gene ID 11186
Synonyms
RDA32; Ras association domain-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MIWRRAALAGTRLVWSRSGSAGWLDRAAGAAGAAAAAASGMESNTSSSLENLATAPVNQI
QETISDNCVVIFSKTSCSYCTMAKKLFHDMNVNYKVVELDLLEYGNQFQDALYKMTGERT
VPRIFVNGTFIGGATDTHRLHKEGKLLPLVHQCYLKKSKRKEFQ
Target Bioclass
Other
Subcellular location
Nucleus; Cytoplasm, cytoskeleton
Function
Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage.
Uniprot ID
Q9NS23
Ensemble ID
ENST00000327761.7
HGNC ID
HGNC:9882

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K216(8.70)  LDD0277  [1]
IA-alkyne
 Probe Info  		C341(2.39)  LDD2183  [2]
DBIA
 Probe Info  		C341(0.95)  LDD0531  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C341(0.95)  LDD0531  [3]
 LDCM0216  AC100 HCT 116 C341(0.84)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C341(0.93)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C341(0.87)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C341(0.93)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C341(0.93)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C341(0.98)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C341(0.90)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C341(0.84)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C341(1.03)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C341(0.90)  LDD0542  [3]
 LDCM0227  AC110 HCT 116 C341(0.92)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C341(1.08)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C341(1.06)  LDD0546  [3]
 LDCM0279  AC2 HCT 116 C341(0.92)  LDD0596  [3]
 LDCM0284  AC24 HEK-293T C341(1.00)  LDD1523  [4]
 LDCM0285  AC25 HCT 116 C341(0.83); C102(1.09); C106(1.09)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C341(0.96); C102(1.34); C106(1.34)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C341(1.18); C102(1.21); C106(1.21)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C102(1.17); C106(1.17); C341(1.27)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C341(0.99); C102(1.15); C106(1.15)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C341(1.06)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C102(1.15); C106(1.15); C341(1.27)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C341(1.20); C102(1.26); C106(1.26)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C341(1.14); C102(1.29); C106(1.29)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C341(1.18); C102(1.68); C106(1.68)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C341(1.12); C102(1.40); C106(1.40)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C102(0.96); C106(0.96)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C102(0.97); C106(0.97)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C102(0.91); C106(0.91)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C102(1.02); C106(1.02)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C102(1.16); C106(1.16)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C341(0.95)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C102(1.00); C106(1.00)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C102(1.02); C106(1.02)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C102(1.09); C106(1.09)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C102(1.15); C106(1.15)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C102(1.11); C106(1.11)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C102(1.03); C106(1.03)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C102(1.02); C106(1.02)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C102(0.88); C106(0.88)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C102(0.94); C106(0.94)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C102(1.02); C106(1.02)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C341(1.04)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C102(0.98); C106(0.98)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C102(0.86); C106(0.86)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C102(0.92); C106(0.92)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C102(0.98); C106(0.98)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C102(1.00); C106(1.00)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C102(0.95); C106(0.95)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C102(0.88); C106(0.88)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C341(1.12)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C341(0.91)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C341(1.02)  LDD0639  [3]
 LDCM0324  AC60 HCT 116 C341(0.97)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C341(1.00)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C341(1.12)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C341(1.00)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C341(1.16)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C341(1.01)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C341(0.96)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C341(1.09)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C102(0.92)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C102(1.01)  LDD0650  [3]
 LDCM0335  AC70 HCT 116 C102(1.16)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C102(1.20)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C102(1.00)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C102(1.04)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C102(0.98)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C102(0.95)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C102(1.03)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C102(0.95)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C102(0.86)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C102(0.99)  LDD0661  [3]
 LDCM0345  AC8 HEK-293T C341(1.03)  LDD1569  [4]
 LDCM0346  AC80 HCT 116 C102(0.84)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C102(1.00)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C102(0.90)  LDD0665  [3]
 LDCM0365  AC98 HCT 116 C341(0.98)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C341(0.92)  LDD0683  [3]
 LDCM0275  AKOS034007705 HEK-293T C341(0.93)  LDD1514  [4]
 LDCM0367  CL1 HCT 116 C102(0.84); C106(0.84)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C102(1.45); C106(1.45)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C341(1.14)  LDD0686  [3]
 LDCM0379  CL11 HCT 116 C102(1.61); C106(1.61)  LDD0696  [3]
 LDCM0382  CL112 HCT 116 C341(0.79); C102(1.17); C106(1.17)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C341(1.12); C102(1.30); C106(1.30)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C341(0.95); C102(1.13); C106(1.13)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C341(0.91); C102(1.39); C106(1.39)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C341(0.88); C102(1.51); C106(1.51)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C102(1.24); C106(1.24)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C102(1.06); C106(1.06)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C102(1.03); C106(1.03)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C102(1.50); C106(1.50)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C102(1.02); C106(1.02)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C102(1.02); C106(1.02)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C102(1.00); C106(1.00)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C102(1.00); C106(1.00)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C102(0.94); C106(0.94)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C341(1.04)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C341(0.84)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C341(0.88)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C341(1.14)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C102(1.31); C106(1.31)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C102(0.97); C106(0.97)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C102(1.27); C106(1.27)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C102(1.16); C106(1.16)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C102(1.18); C106(1.18)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C102(1.08); C106(1.08)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C102(1.13); C106(1.13)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C102(0.83); C106(0.83)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C102(1.13); C106(1.13)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C102(1.36); C106(1.36)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C102(2.03); C106(2.03)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C102(1.00); C106(1.00)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C102(1.24); C106(1.24)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C102(2.78); C106(2.78)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C102(1.42); C106(1.42)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C102(1.33); C106(1.33)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C102(1.27); C106(1.27)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C102(1.41); C106(1.41)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C102(0.97); C106(0.97)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C102(1.17); C106(1.17)  LDD0736  [3]
 LDCM0420  CL31 PaTu 8988t C341(0.88)  LDD1299  [3]
 LDCM0421  CL32 PaTu 8988t C341(1.16)  LDD1300  [3]
 LDCM0422  CL33 PaTu 8988t C341(1.05)  LDD1301  [3]
 LDCM0423  CL34 PaTu 8988t C341(1.16)  LDD1302  [3]
 LDCM0424  CL35 PaTu 8988t C341(1.24)  LDD1303  [3]
 LDCM0425  CL36 PaTu 8988t C341(0.84)  LDD1304  [3]
 LDCM0426  CL37 PaTu 8988t C341(1.24)  LDD1305  [3]
 LDCM0428  CL39 PaTu 8988t C341(1.03)  LDD1307  [3]
 LDCM0429  CL4 HCT 116 C102(1.17); C106(1.17)  LDD0746  [3]
 LDCM0430  CL40 PaTu 8988t C341(1.06)  LDD1309  [3]
 LDCM0431  CL41 PaTu 8988t C341(1.06)  LDD1310  [3]
 LDCM0432  CL42 PaTu 8988t C341(1.17)  LDD1311  [3]
 LDCM0433  CL43 PaTu 8988t C341(1.22)  LDD1312  [3]
 LDCM0434  CL44 PaTu 8988t C341(1.37)  LDD1313  [3]
 LDCM0435  CL45 PaTu 8988t C341(1.11)  LDD1314  [3]
 LDCM0436  CL46 HCT 116 C341(1.05)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C341(1.07)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C341(1.19)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C341(1.18)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C102(1.10); C106(1.10)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C341(1.00)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C341(1.05)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C341(1.27)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C341(0.89)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C341(1.11)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C341(1.08)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C341(1.04)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C341(0.96)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C341(0.96)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C341(1.01)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C102(0.93); C106(0.93)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C341(1.10)  LDD0769  [3]
 LDCM0453  CL61 PaTu 8988t C341(0.99)  LDD1332  [3]
 LDCM0454  CL62 PaTu 8988t C341(1.07)  LDD1333  [3]
 LDCM0455  CL63 PaTu 8988t C341(1.18)  LDD1334  [3]
 LDCM0456  CL64 PaTu 8988t C341(1.18)  LDD1335  [3]
 LDCM0457  CL65 PaTu 8988t C341(1.20)  LDD1336  [3]
 LDCM0458  CL66 PaTu 8988t C341(1.08)  LDD1337  [3]
 LDCM0459  CL67 PaTu 8988t C341(1.23)  LDD1338  [3]
 LDCM0460  CL68 PaTu 8988t C341(1.50)  LDD1339  [3]
 LDCM0461  CL69 PaTu 8988t C341(1.30)  LDD1340  [3]
 LDCM0462  CL7 HCT 116 C102(1.02); C106(1.02)  LDD0779  [3]
 LDCM0463  CL70 PaTu 8988t C341(1.29)  LDD1342  [3]
 LDCM0464  CL71 PaTu 8988t C341(1.19)  LDD1343  [3]
 LDCM0465  CL72 PaTu 8988t C341(1.03)  LDD1344  [3]
 LDCM0466  CL73 PaTu 8988t C341(1.42)  LDD1345  [3]
 LDCM0467  CL74 PaTu 8988t C341(1.25)  LDD1346  [3]
 LDCM0469  CL76 HCT 116 C102(1.38); C106(1.38)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C102(0.98); C106(0.98)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C102(1.33); C106(1.33)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C102(1.46); C106(1.46)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C102(1.38); C106(1.38)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C102(1.15); C106(1.15)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C102(1.65); C106(1.65)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C102(1.75); C106(1.75)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C102(1.56); C106(1.56)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C102(2.54); C106(2.54)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C102(1.34); C106(1.34)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C102(1.51); C106(1.51)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C102(1.58); C106(1.58)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C102(1.58); C106(1.58)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C102(2.30); C106(2.30)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C102(0.91); C106(0.91)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C102(2.69); C106(2.69)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C341(0.82)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C341(0.73)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C341(0.98)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C341(0.92)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C341(0.84)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C341(0.82)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C341(0.90)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C341(1.02)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C341(0.99)  LDD0811  [3]
 LDCM0468  Fragment33 PaTu 8988t C341(1.32)  LDD1347  [3]
 LDCM0566  Fragment4 Ramos C341(1.25)  LDD2184  [2]
 LDCM0427  Fragment51 PaTu 8988t C341(1.29)  LDD1306  [3]
 LDCM0569  Fragment7 Ramos C341(1.22)  LDD2186  [2]
 LDCM0022  KB02 HEK-293T C341(0.86)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C341(0.83)  LDD1497  [4]
 LDCM0024  KB05 MKN45 C40(1.28)  LDD3332  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone-lysine N-methyltransferase SUV39H1 (SUV39H1) Histone-lysine methyltransferase family O43463
Serine--tRNA ligase, cytoplasmic (SARS1) Class-II aminoacyl-tRNA synthetase family P49591
NADH dehydrogenase flavoprotein 2, mitochondrial (NDUFV2) Complex I 24 kDa subunit family P19404
Lysine-specific histone demethylase 1A (KDM1A) Flavin monoamine oxidase family O60341
Frataxin, mitochondrial (FXN) Frataxin family Q16595
E3 ubiquitin-protein ligase Mdm2 (MDM2) MDM2/MDM4 family Q00987
Serine/threonine-protein kinase 3 (STK3) STE Ser/Thr protein kinase family Q13188
Serine/threonine-protein kinase 4 (STK4) STE Ser/Thr protein kinase family Q13043
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
GTPase HRas (HRAS) Ras family P01112
Eukaryotic translation initiation factor 2 subunit 3 (EIF2S3) Classic translation factor GTPase family P41091
Tyrosyl-DNA phosphodiesterase 1 (TDP1) Tyrosyl-DNA phosphodiesterase family Q9NUW8
Ataxin-3 (ATXN3) . P54252
Transcription factor E4F1 (E4F1) . Q66K89
Transporter and channel
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apolipoprotein E (APOE) Apolipoprotein A1/A4/E family P02649
Gamma-aminobutyric acid receptor-associated protein (GABARAP) ATG8 family O95166
mRNA export factor GLE1 (GLE1) GLE1 family Q53GS7
Huntingtin (HTT) Huntingtin family P42858
Junctophilin-3 (JPH3) Junctophilin family Q8WXH2
Cell division cycle protein 20 homolog (CDC20) WD repeat CDC20/Fizzy family Q12834
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-D10 (HOXD10) Abd-B homeobox family P28358
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gamma-aminobutyric acid receptor-associated protein-like 2 (GABARAPL2) ATG8 family P60520
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) ATG8 family Q9GZQ8
Microtubule-associated proteins 1A/1B light chain 3C (MAP1LC3C) ATG8 family Q9BXW4
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF) CDIP1/LITAF family Q99732
Death domain-associated protein 6 (DAXX) DAXX family Q9UER7
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
RNA-binding protein EWS (EWSR1) RRM TET family Q01844
Methyl-CpG-binding protein 2 (MECP2) . P51608
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840