Details of the Target

General Information of Target

Target ID LDTP12344
Target Name Myoneurin (MYNN)
Gene Name MYNN
Gene ID 55892
Synonyms
OSZF; ZBTB31; Myoneurin; Zinc finger and BTB domain-containing protein 31
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLSHNTMMKQRKQQATAIMKEVHGNDVDGMDLGKKVSIPRDIMLEELSHLSNRGARLFKM
RQRRSDKYTFENFQYQSRAQINHSIAMQNGKVDGSNLEGGSQQAPLTPPNTPDPRSPPNP
DNIAPGYSGPLKEIPPEKFNTTAVPKYYQSPWEQAISNDPELLEALYPKLFKPEGKAELP
DYRSFNRVATPFGGFEKASRMVKFKVPDFELLLLTDPRFMSFVNPLSGRRSFNRTPKGWI
SENIPIVITTEPTDDTTVPESEDL
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Uniprot ID
Q9NPC7
Ensemble ID
ENST00000349841.10
HGNC ID
HGNC:14955
ChEMBL ID
CHEMBL5069362

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.T255I .
LNCaP clone FGC SNV: p.G597E DBIA    Probe Info 
MFE319 Insertion: p.L606FfsTer9 .
OVCAR4 SNV: p.G569V .
SKMEL2 SNV: p.K556N DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C342(1.82)  LDD1701  [1]
DBIA
 Probe Info  		C371(0.98)  LDD0078  [2]
HHS-465
 Probe Info  		K356(0.00); K359(0.00); Y358(0.00)  LDD2240  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C342(1.00)  LDD1507  [4]
 LDCM0215  AC10 HCT 116 C371(1.26)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C371(1.04)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C371(1.08)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C371(1.09)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C371(1.12)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C371(1.02)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C371(1.04)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C371(1.18)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C371(1.00)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C371(0.99)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C371(0.97)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C371(1.13)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C371(1.17)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C371(1.26)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C371(1.13)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C371(0.91)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C371(1.06)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C371(1.03)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C371(0.88)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C371(0.92)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C371(0.94)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C371(0.84)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C371(0.97)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C371(1.09)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C371(0.93)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C371(0.93)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C371(1.15)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C371(0.88)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C371(0.94)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C371(1.02)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C371(1.05)  LDD0562  [2]
 LDCM0259  AC14 HCT 116 C371(1.13)  LDD0576  [2]
 LDCM0270  AC15 HCT 116 C371(1.11)  LDD0587  [2]
 LDCM0276  AC17 HEK-293T C371(1.43)  LDD0874  [2]
 LDCM0277  AC18 HEK-293T C371(1.03)  LDD0875  [2]
 LDCM0278  AC19 HEK-293T C371(1.02)  LDD0876  [2]
 LDCM0280  AC20 HEK-293T C371(0.98)  LDD0878  [2]
 LDCM0281  AC21 HEK-293T C371(0.90)  LDD0879  [2]
 LDCM0282  AC22 HEK-293T C371(0.93)  LDD0880  [2]
 LDCM0283  AC23 HEK-293T C371(0.87)  LDD0881  [2]
 LDCM0284  AC24 HEK-293T C371(0.78)  LDD0882  [2]
 LDCM0285  AC25 HCT 116 C371(0.96)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C371(1.24)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C371(1.26)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C371(1.20)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C371(1.52)  LDD0606  [2]
 LDCM0291  AC30 HCT 116 C371(1.42)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C371(1.23)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C371(1.31)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C371(1.33)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C371(1.57)  LDD0612  [2]
 LDCM0296  AC35 HEK-293T C371(1.02)  LDD0894  [2]
 LDCM0297  AC36 HEK-293T C371(0.71)  LDD0895  [2]
 LDCM0298  AC37 HEK-293T C371(1.08)  LDD0896  [2]
 LDCM0299  AC38 HEK-293T C371(0.88)  LDD0897  [2]
 LDCM0300  AC39 HEK-293T C371(0.85)  LDD0898  [2]
 LDCM0302  AC40 HEK-293T C371(0.69)  LDD0900  [2]
 LDCM0303  AC41 HEK-293T C371(0.81)  LDD0901  [2]
 LDCM0304  AC42 HEK-293T C371(0.82)  LDD0902  [2]
 LDCM0305  AC43 HEK-293T C371(1.01)  LDD0903  [2]
 LDCM0306  AC44 HEK-293T C371(0.84)  LDD0904  [2]
 LDCM0307  AC45 HEK-293T C371(0.82)  LDD0905  [2]
 LDCM0308  AC46 HCT 116 C371(1.19)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C371(1.13)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C371(1.33)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C371(1.19)  LDD0628  [2]
 LDCM0313  AC50 HCT 116 C371(1.22)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C371(1.27)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C371(1.40)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C371(1.40)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C371(1.25)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C371(1.58)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C371(2.01)  LDD0636  [2]
 LDCM0320  AC57 HEK-293T C342(1.03)  LDD1559  [4]
 LDCM0323  AC6 HCT 116 C371(1.21)  LDD0640  [2]
 LDCM0326  AC62 HEK-293T C342(1.02); C371(1.03)  LDD1565  [4]
 LDCM0327  AC63 HEK-293T C342(1.14)  LDD1566  [4]
 LDCM0334  AC7 HCT 116 C371(1.16)  LDD0651  [2]
 LDCM0345  AC8 HCT 116 C371(1.03)  LDD0662  [2]
 LDCM0365  AC98 HCT 116 C371(1.08)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C371(1.06)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C371(1.05)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C371(1.11)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C371(1.41)  LDD0592  [2]
 LDCM0020  ARS-1620 HCC44 C371(0.98)  LDD0078  [2]
 LDCM0368  CL10 HEK-293T C342(1.11); C371(0.91)  LDD1572  [4]
 LDCM0369  CL100 HEK-293T C342(1.00)  LDD1573  [4]
 LDCM0370  CL101 HCT 116 C371(1.28)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C371(0.98)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C371(0.98)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C371(1.12)  LDD0690  [2]
 LDCM0374  CL105 HEK-293T C371(0.96)  LDD0972  [2]
 LDCM0375  CL106 HEK-293T C371(1.02)  LDD0973  [2]
 LDCM0376  CL107 HEK-293T C371(1.12)  LDD0974  [2]
 LDCM0377  CL108 HEK-293T C371(1.19)  LDD0975  [2]
 LDCM0378  CL109 HEK-293T C371(0.91)  LDD0976  [2]
 LDCM0379  CL11 HEK-293T C342(1.28)  LDD1583  [4]
 LDCM0380  CL110 HEK-293T C371(0.91)  LDD0978  [2]
 LDCM0381  CL111 HEK-293T C371(0.82)  LDD0979  [2]
 LDCM0382  CL112 HCT 116 C371(1.17)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C371(1.29)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C371(1.17)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C371(1.32)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C371(1.24)  LDD0703  [2]
 LDCM0387  CL117 HEK-293T C371(0.83)  LDD0985  [2]
 LDCM0388  CL118 HEK-293T C371(0.61)  LDD0986  [2]
 LDCM0389  CL119 HEK-293T C371(0.75)  LDD0987  [2]
 LDCM0391  CL120 HEK-293T C371(0.80)  LDD0989  [2]
 LDCM0392  CL121 HCT 116 C371(0.73)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C371(1.40)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C371(1.24)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C371(1.35)  LDD0712  [2]
 LDCM0397  CL126 HEK-293T C342(1.12)  LDD1601  [4]
 LDCM0399  CL128 HEK-293T C342(1.05)  LDD1603  [4]
 LDCM0401  CL14 HEK-293T C342(1.25)  LDD1605  [4]
 LDCM0403  CL16 HEK-293T C371(1.16)  LDD1001  [2]
 LDCM0404  CL17 HEK-293T C371(1.32)  LDD1002  [2]
 LDCM0405  CL18 HEK-293T C371(1.37)  LDD1003  [2]
 LDCM0406  CL19 HEK-293T C371(1.18)  LDD1004  [2]
 LDCM0407  CL2 HEK-293T C342(1.22)  LDD1611  [4]
 LDCM0408  CL20 HEK-293T C371(1.05)  LDD1006  [2]
 LDCM0409  CL21 HEK-293T C371(1.31)  LDD1007  [2]
 LDCM0410  CL22 HEK-293T C371(1.36)  LDD1008  [2]
 LDCM0411  CL23 HEK-293T C371(1.08)  LDD1009  [2]
 LDCM0412  CL24 HEK-293T C371(1.31)  LDD1010  [2]
 LDCM0413  CL25 HEK-293T C371(1.21)  LDD1011  [2]
 LDCM0414  CL26 HEK-293T C371(0.99)  LDD1012  [2]
 LDCM0415  CL27 HEK-293T C371(1.19)  LDD1013  [2]
 LDCM0416  CL28 HEK-293T C371(1.16)  LDD1014  [2]
 LDCM0417  CL29 HEK-293T C371(1.07)  LDD1015  [2]
 LDCM0419  CL30 HEK-293T C371(1.17)  LDD1017  [2]
 LDCM0420  CL31 HCT 116 C371(1.02)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C371(1.05)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C371(1.08)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C371(1.11)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C371(1.17)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C371(1.18)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C371(1.15)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C371(1.09)  LDD0745  [2]
 LDCM0429  CL4 HEK-293T C342(0.95)  LDD1633  [4]
 LDCM0430  CL40 HCT 116 C371(1.32)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C371(1.04)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C371(1.14)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C371(1.09)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C371(1.08)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C371(1.12)  LDD0752  [2]
 LDCM0436  CL46 HEK-293T C342(1.02); C371(0.95)  LDD1640  [4]
 LDCM0437  CL47 HEK-293T C342(1.14)  LDD1641  [4]
 LDCM0440  CL5 HEK-293T C342(1.09)  LDD1644  [4]
 LDCM0441  CL50 HEK-293T C342(1.14)  LDD1645  [4]
 LDCM0443  CL52 HEK-293T C342(1.03)  LDD1646  [4]
 LDCM0444  CL53 HEK-293T C342(1.04)  LDD1647  [4]
 LDCM0449  CL58 HEK-293T C342(1.09); C371(0.98)  LDD1652  [4]
 LDCM0450  CL59 HEK-293T C342(1.15)  LDD1653  [4]
 LDCM0453  CL61 HCT 116 C371(1.13)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C371(1.17)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C371(1.04)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C371(1.05)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C371(0.90)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C371(1.35)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C371(0.97)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C371(1.18)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C371(1.15)  LDD0778  [2]
 LDCM0463  CL70 HCT 116 C371(1.07)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C371(1.16)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C371(0.93)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C371(1.17)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C371(1.03)  LDD0784  [2]
 LDCM0469  CL76 HEK-293T C342(1.13)  LDD1672  [4]
 LDCM0470  CL77 HEK-293T C342(0.99)  LDD1673  [4]
 LDCM0476  CL82 HEK-293T C342(1.06); C371(1.03)  LDD1679  [4]
 LDCM0477  CL83 HEK-293T C342(1.04)  LDD1680  [4]
 LDCM0480  CL86 HEK-293T C342(1.20)  LDD1683  [4]
 LDCM0482  CL88 HEK-293T C342(1.00)  LDD1685  [4]
 LDCM0483  CL89 HEK-293T C342(1.16)  LDD1686  [4]
 LDCM0489  CL94 HEK-293T C342(1.03); C371(0.91)  LDD1692  [4]
 LDCM0490  CL95 HEK-293T C342(1.05)  LDD1693  [4]
 LDCM0493  CL98 HEK-293T C342(1.22)  LDD1696  [4]
 LDCM0468  Fragment33 HCT 116 C371(0.96)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C371(1.76)  LDD0744  [2]
 LDCM0022  KB02 HCT 116 C371(1.54)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C371(1.19)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C371(1.53)  LDD0082  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (DLST) 2-oxoacid dehydrogenase family P36957
Serine/threonine-protein kinase Nek7 (NEK7) NEK Ser/Thr protein kinase family Q8TDX7
TGF-beta receptor type-2 (TGFBR2) TKL Ser/Thr protein kinase family P37173
Ferredoxin-fold anticodon-binding domain-containing protein 1 (FDXACB1) . Q9BRP7
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calreticulin (CALR) Calreticulin family P27797
Junctophilin-3 (JPH3) Junctophilin family Q8WXH2
Cadherin-1 (CDH1) . P12830
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Acidic leucine-rich nuclear phosphoprotein 32 family member B (ANP32B) ANP32 family Q92688
Cyclin-dependent kinase 5 activator 1 (CDK5R1) Cyclin-dependent kinase 5 activator family Q15078
Progranulin (GRN) Granulin family P28799
Serpin H1 (SERPINH1) Serpin family P50454

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402