General Information of Target

Target ID LDTP12260
Target Name GPN-loop GTPase 1 (GPN1)
Gene Name GPN1
Gene ID 11321
Synonyms
MBDIN; RPAP4; XAB1; GPN-loop GTPase 1; EC 3.6.5.-; MBD2-interacting protein; MBDin; RNAPII-associated protein 4; XPA-binding protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGRAGTGTGGEAVAAVVAGPLLLLLLARPPPASAGYSGKSEVGLVSEHFSQAPQRLSFYS
WYGSARLFRFRVPPDAVLLRWLLQVSRESGAACTDAEITVHFRSGAPPVINPLGTSFPDD
TAVQPSFQVGVPLSTTPRSNASVNVSHPAPGDWFVAAHLPPSSQKIELKGLAPTCAYVFQ
PELLVTRVVEISIMEPDVPLPQTLLSHPSYLKVFVPDYTRELLLELRDCVSNGSLGCPVR
LTVGPVTLPSNFQKVLTCTGAPWPCRLLLPSPPWDRWLQVTAESLVGPLGTVAFSAVAAL
TACRPRSVTIQPLLQSSQNQSFNASSGLLSPSPDHQDLGRSGRVDRSPFCLTNYPVTRED
MDVVSVHFQPLDRVSVRVCSDTPSVMRLRLNTGMDSGGSLTISLRANKTEMRNETVVVAC
VNAASPFLGFNTSLNCTTAFFQGYPLSLSAWSRRANLIIPYPETDNWYLSLQLMCPENAE
DCEQAVVHVETTLYLVPCLNDCGPYGQCLLLRRHSYLYASCSCKAGWRGWSCTDNSTAQT
VAQQRAATLLLTLSNLMFLAPIAVSVRRFFLVEASVYAYTMFFSTFYHACDQPGEAVLCI
LSYDTLQYCDFLGSGAAIWVTILCMARLKTVLKYVLFLLGTLVIAMSLQLDRRGMWNMLG
PCLFAFVIMASMWAYRCGHRRQCYPTSWQRWAFYLLPGVSMASVGIAIYTSMMTSDNYYY
THSIWHILLAGSAALLLPPPDQPAEPWACSQKFPCHYQICKNDREELYAVT
Target Bioclass
Enzyme
Family
GPN-loop GTPase family
Subcellular location
Cytoplasm
Function
Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import. Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. May be involved in nuclear localization of XPA.
Uniprot ID
Q9HCN4
Ensemble ID
ENST00000264718.7
HGNC ID
HGNC:17030

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
C32 Substitution: p.S4F .
ECC2 SNV: p.A142V .
KARPAS299 SNV: p.S364L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info 
K278(5.72)  LDD0277  [1]
Probe 1
 Probe Info 
Y269(9.32); Y273(12.46)  LDD3495  [2]
DBIA
 Probe Info 
C21(1.02)  LDD0602  [3]
5E-2FA
 Probe Info 
N.A.  LDD2235  [4]
m-APA
 Probe Info 
N.A.  LDD2233  [4]
IA-alkyne
 Probe Info 
C21(0.00); C174(0.00)  LDD0036  [5]
Lodoacetamide azide
 Probe Info 
C21(0.00); C174(0.00)  LDD0037  [5]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info 
N.A.  LDD0396  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C21(0.95)  LDD1507  [7]
 LDCM0215  AC10 HEK-293T C21(0.92); C174(1.05)  LDD1508  [7]
 LDCM0226  AC11 HEK-293T C21(1.03)  LDD1509  [7]
 LDCM0237  AC12 HEK-293T C21(0.96); C174(0.97)  LDD1510  [7]
 LDCM0259  AC14 HEK-293T C21(1.05); C174(1.09)  LDD1512  [7]
 LDCM0270  AC15 HEK-293T C21(1.00); C174(1.53)  LDD1513  [7]
 LDCM0276  AC17 HEK-293T C21(0.86)  LDD1515  [7]
 LDCM0277  AC18 HEK-293T C21(0.93); C174(1.23)  LDD1516  [7]
 LDCM0278  AC19 HEK-293T C21(0.88)  LDD1517  [7]
 LDCM0279  AC2 HEK-293T C21(0.89); C174(1.14)  LDD1518  [7]
 LDCM0280  AC20 HEK-293T C21(1.03); C174(0.89)  LDD1519  [7]
 LDCM0281  AC21 HEK-293T C21(1.00); C174(1.06)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C21(1.05); C174(0.81)  LDD1521  [7]
 LDCM0283  AC23 HEK-293T C21(0.98); C174(0.91)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C21(0.94); C174(0.90)  LDD1523  [7]
 LDCM0285  AC25 HCT 116 C21(1.02)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C21(0.94)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C21(0.92)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C21(0.94)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C21(0.83)  LDD0606  [3]
 LDCM0290  AC3 HEK-293T C21(1.01)  LDD1529  [7]
 LDCM0291  AC30 HCT 116 C21(0.83)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C21(0.98)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C21(0.82)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C21(0.80)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C21(0.86)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C21(0.56)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C21(0.57)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C21(0.70)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C21(0.74)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C21(0.62)  LDD0617  [3]
 LDCM0301  AC4 HEK-293T C21(0.97); C174(1.06)  LDD1540  [7]
 LDCM0302  AC40 HCT 116 C21(0.46)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C21(0.84)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C21(0.74)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C21(0.80)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C21(0.67)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C21(0.60)  LDD0624  [3]
 LDCM0308  AC46 HEK-293T C21(1.05); C174(0.84)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C21(1.02); C174(0.80)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C21(0.97); C174(0.96)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C21(0.89)  LDD1550  [7]
 LDCM0312  AC5 HEK-293T C21(1.02); C174(1.15)  LDD1551  [7]
 LDCM0313  AC50 HEK-293T C21(0.88); C174(1.04)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C21(0.98)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C21(1.02); C174(1.07)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C21(1.07); C174(0.89)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C21(0.96); C174(0.92)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C21(0.95); C174(0.90)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C21(0.93); C174(1.04)  LDD1558  [7]
 LDCM0320  AC57 HEK-293T C21(0.90)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C21(0.85); C174(1.04)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C21(1.09)  LDD1561  [7]
 LDCM0323  AC6 HEK-293T C21(1.00); C174(0.84)  LDD1562  [7]
 LDCM0324  AC60 HEK-293T C21(0.99); C174(1.05)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C21(0.99); C174(0.98)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C21(0.99); C174(1.09)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C21(1.00); C174(0.97)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C21(0.98); C174(1.02)  LDD1567  [7]
 LDCM0334  AC7 HEK-293T C21(1.03); C174(0.82)  LDD1568  [7]
 LDCM0345  AC8 HEK-293T C21(0.96); C174(0.93)  LDD1569  [7]
 LDCM0349  AC83 HCT 116 C21(0.93)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C21(1.08)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C21(0.96)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C21(1.07)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C21(1.00)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C21(0.95)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C21(0.91)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C21(1.00)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C21(1.01)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C21(0.96)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C21(0.89)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C21(1.15)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C21(1.05)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C21(1.13)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C21(1.09)  LDD0681  [3]
 LDCM0248  AKOS034007472 HEK-293T C21(1.02); C174(0.86)  LDD1511  [7]
 LDCM0356  AKOS034007680 HEK-293T C21(0.92)  LDD1570  [7]
 LDCM0275  AKOS034007705 HEK-293T C21(0.89); C174(0.86)  LDD1514  [7]
 LDCM0367  CL1 HEK-293T C21(0.88)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C21(1.17); C174(0.62)  LDD1572  [7]
 LDCM0369  CL100 HEK-293T C21(1.11)  LDD1573  [7]
 LDCM0370  CL101 HEK-293T C21(0.90)  LDD1574  [7]
 LDCM0371  CL102 HEK-293T C21(0.96)  LDD1575  [7]
 LDCM0372  CL103 HEK-293T C21(1.04)  LDD1576  [7]
 LDCM0373  CL104 HEK-293T C21(1.04)  LDD1577  [7]
 LDCM0374  CL105 HEK-293T C21(0.80)  LDD1578  [7]
 LDCM0375  CL106 HEK-293T C21(0.95)  LDD1579  [7]
 LDCM0376  CL107 HEK-293T C21(1.01)  LDD1580  [7]
 LDCM0377  CL108 HEK-293T C21(1.02)  LDD1581  [7]
 LDCM0378  CL109 HEK-293T C21(0.96)  LDD1582  [7]
 LDCM0379  CL11 HEK-293T C21(1.10); C174(1.40)  LDD1583  [7]
 LDCM0380  CL110 HEK-293T C21(0.99)  LDD1584  [7]
 LDCM0381  CL111 HEK-293T C21(0.99)  LDD1585  [7]
 LDCM0382  CL112 HCT 116 C21(0.93)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C21(0.86)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C21(0.80)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C21(0.88)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C21(0.74)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C21(0.38)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C21(0.72)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C21(0.72)  LDD0706  [3]
 LDCM0390  CL12 HEK-293T C21(0.97); C174(0.96)  LDD1594  [7]
 LDCM0391  CL120 HCT 116 C21(0.74)  LDD0708  [3]
 LDCM0392  CL121 HEK-293T C21(0.88)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C21(1.02)  LDD1597  [7]
 LDCM0394  CL123 HEK-293T C21(0.99)  LDD1598  [7]
 LDCM0395  CL124 HEK-293T C21(0.94)  LDD1599  [7]
 LDCM0396  CL125 HEK-293T C21(0.94)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C21(1.02)  LDD1601  [7]
 LDCM0398  CL127 HEK-293T C21(0.95)  LDD1602  [7]
 LDCM0399  CL128 HEK-293T C21(1.01)  LDD1603  [7]
 LDCM0400  CL13 HEK-293T C21(0.81)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C21(0.98)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C21(1.07)  LDD1606  [7]
 LDCM0403  CL16 HCT 116 C21(0.81)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C21(1.07)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C21(1.03)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C21(1.16)  LDD0723  [3]
 LDCM0407  CL2 HEK-293T C21(1.03)  LDD1611  [7]
 LDCM0408  CL20 HCT 116 C21(1.11)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C21(1.20)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C21(1.16)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C21(0.82)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C21(0.92)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C21(0.86)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C21(0.71)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C21(1.10)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C21(0.81)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C21(1.16)  LDD0734  [3]
 LDCM0418  CL3 HEK-293T C21(1.01)  LDD1622  [7]
 LDCM0419  CL30 HCT 116 C21(1.01)  LDD0736  [3]
 LDCM0420  CL31 HEK-293T C21(1.03)  LDD1624  [7]
 LDCM0421  CL32 HEK-293T C21(1.00); C174(0.86)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C21(1.12); C174(0.77)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C21(1.09); C174(0.91)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C21(1.09); C174(0.78)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C21(1.04); C174(0.85)  LDD1629  [7]
 LDCM0426  CL37 HEK-293T C21(0.93)  LDD1630  [7]
 LDCM0428  CL39 HEK-293T C21(1.00)  LDD1632  [7]
 LDCM0429  CL4 HEK-293T C21(1.10)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C21(1.03)  LDD1634  [7]
 LDCM0431  CL41 HEK-293T C21(0.93)  LDD1635  [7]
 LDCM0432  CL42 HEK-293T C21(0.88); C174(0.91)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C21(1.05)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C21(1.03); C174(0.97)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C21(0.96); C174(0.86)  LDD1639  [7]
 LDCM0436  CL46 HCT 116 C21(0.80)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C21(0.84)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C21(0.82)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C21(0.96)  LDD0756  [3]
 LDCM0440  CL5 HEK-293T C21(0.94)  LDD1644  [7]
 LDCM0441  CL50 HCT 116 C21(0.86)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C21(1.06)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C21(0.79)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C21(0.79)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C21(0.70)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C21(1.00)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C21(0.82)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C21(0.85)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C21(0.84)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C21(1.08)  LDD0767  [3]
 LDCM0451  CL6 HEK-293T C21(0.91); C174(1.02)  LDD1654  [7]
 LDCM0452  CL60 HCT 116 C21(0.81)  LDD0769  [3]
 LDCM0453  CL61 HEK-293T C21(0.89)  LDD1656  [7]
 LDCM0454  CL62 HEK-293T C21(1.03)  LDD1657  [7]
 LDCM0455  CL63 HEK-293T C21(0.97)  LDD1658  [7]
 LDCM0456  CL64 HEK-293T C21(1.01)  LDD1659  [7]
 LDCM0457  CL65 HEK-293T C21(0.88)  LDD1660  [7]
 LDCM0458  CL66 HEK-293T C21(0.93); C174(0.97)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C21(1.09)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C21(1.07); C174(1.15)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C21(1.11); C174(0.76)  LDD1664  [7]
 LDCM0462  CL7 HEK-293T C21(1.06)  LDD1665  [7]
 LDCM0463  CL70 HEK-293T C21(1.07); C174(0.96)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C21(1.04); C174(1.00)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C21(0.97); C174(0.72)  LDD1668  [7]
 LDCM0466  CL73 HEK-293T C21(0.93)  LDD1669  [7]
 LDCM0467  CL74 HEK-293T C21(0.93)  LDD1670  [7]
 LDCM0469  CL76 HEK-293T C21(1.04)  LDD1672  [7]
 LDCM0470  CL77 HEK-293T C21(0.91)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C21(0.90); C174(0.95)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C21(1.10)  LDD1675  [7]
 LDCM0473  CL8 HEK-293T C21(1.29); C174(0.98)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C21(1.08); C174(0.93)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C21(1.09); C174(0.91)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C21(1.09); C174(0.85)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C21(1.03); C174(0.36)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C21(1.03); C174(0.83)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C21(0.91)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C21(1.04)  LDD1683  [7]
 LDCM0481  CL87 HEK-293T C21(0.99)  LDD1684  [7]
 LDCM0482  CL88 HEK-293T C21(1.05)  LDD1685  [7]
 LDCM0483  CL89 HEK-293T C21(0.93)  LDD1686  [7]
 LDCM0484  CL9 HEK-293T C21(1.05); C174(0.97)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C21(0.99); C174(0.86)  LDD1688  [7]
 LDCM0486  CL91 HEK-293T C21(1.05)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C21(1.06); C174(1.23)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C21(1.10); C174(0.87)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C21(1.07); C174(0.86)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C21(1.02); C174(0.73)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C21(1.08); C174(0.86)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C21(0.87)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C21(1.06)  LDD1696  [7]
 LDCM0494  CL99 HEK-293T C21(1.00)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C21(0.90)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C21(1.03)  LDD1671  [7]
 LDCM0427  Fragment51 HEK-293T C21(0.92)  LDD1631  [7]
 LDCM0022  KB02 HEK-293T C21(0.91)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C21(0.91)  LDD1497  [7]
 LDCM0024  KB05 COLO792 C35(2.18)  LDD3310  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
GPN-loop GTPase 2 (GPN2) GPN-loop GTPase family Q9H9Y4
GPN-loop GTPase 3 (GPN3) GPN-loop GTPase family Q9UHW5
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 (RPAP2) RPAP2 family Q8IXW5

References

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Mass spectrometry data entry: PXD028270
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Mass spectrometry data entry: PXD042377
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Mass spectrometry data entry: PXD028853
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Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD047840