Details of the Target

General Information of Target

Target ID LDTP12157
Target Name Pleckstrin homology domain-containing family A member 1 (PLEKHA1)
Gene Name PLEKHA1
Gene ID 59338
Synonyms
TAPP1; Pleckstrin homology domain-containing family A member 1; PH domain-containing family A member 1; Tandem PH domain-containing protein 1; TAPP-1
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
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Sequence
MEGVLYKWTNYLTGWQPRWFVLDNGILSYYDSQDDVCKGSKGSIKMAVCEIKVHSADNTR
MELIIPGEQHFYMKAVNAAERQRWLVALGSSKACLTDTRTKKEKEISETSESLKTKMSEL
RLYCDLLMQQVHTIQEFVHHDENHSSPSAENMNEASSLLSATCNTFITTLEECVKIANAK
FKPEMFQLHHPDPLVSPVSPSPVQMMKRSVSHPGSCSSERSSHSIKEPVSTLHRLSQRRR
RTYSDTDSCSDIPLEDPDRPVHCSKNTLNGDLASATIPEESRLMAKKQSESEDTLPSFSS
Target Bioclass
Other
Subcellular location
Cytoplasm
Function Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane.
Uniprot ID
Q9HB21
Ensemble ID
ENST00000368988.5
HGNC ID
HGNC:14335
ChEMBL ID
CHEMBL3763005

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
KPNYN SNV: p.K242E .
MFE296 SNV: p.R329H DBIA    Probe Info 
NCIH2170 SNV: p.E159G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DBIA
 Probe Info  		C11(1.16)  LDD3312  [2]
ATP probe
 Probe Info  		N.A.  LDD0199  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
ENE
 Probe Info  		N.A.  LDD0006  [5]
IPM
 Probe Info  		N.A.  LDD0147  [6]
VSF
 Probe Info  		N.A.  LDD0007  [5]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [7]
AOyne
 Probe Info  		14.80  LDD0443  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C11(1.06)  LDD0812  [9]
 LDCM0215  AC10 HEK-293T C11(1.13); C163(1.01)  LDD0813  [9]
 LDCM0216  AC100 HEK-293T C11(1.02); C163(0.92)  LDD0814  [9]
 LDCM0217  AC101 HEK-293T C11(0.96); C163(0.99)  LDD0815  [9]
 LDCM0218  AC102 HEK-293T C11(1.01); C163(0.98)  LDD0816  [9]
 LDCM0219  AC103 HEK-293T C11(1.11); C163(1.10)  LDD0817  [9]
 LDCM0220  AC104 HEK-293T C11(1.09); C163(1.01)  LDD0818  [9]
 LDCM0221  AC105 HEK-293T C11(0.98); C163(0.95)  LDD0819  [9]
 LDCM0222  AC106 HEK-293T C11(0.88); C163(1.01)  LDD0820  [9]
 LDCM0223  AC107 HEK-293T C11(1.02); C163(0.98)  LDD0821  [9]
 LDCM0224  AC108 HEK-293T C11(0.91); C163(0.83)  LDD0822  [9]
 LDCM0225  AC109 HEK-293T C11(1.05); C163(1.01)  LDD0823  [9]
 LDCM0226  AC11 HEK-293T C11(1.11); C163(1.16)  LDD0824  [9]
 LDCM0227  AC110 HEK-293T C11(1.35); C163(1.33)  LDD0825  [9]
 LDCM0228  AC111 HEK-293T C11(1.51); C163(1.74)  LDD0826  [9]
 LDCM0229  AC112 HEK-293T C11(1.35); C163(1.53)  LDD0827  [9]
 LDCM0230  AC113 HEK-293T C11(1.00); C163(0.98)  LDD0828  [9]
 LDCM0231  AC114 HEK-293T C11(0.93); C163(0.97)  LDD0829  [9]
 LDCM0232  AC115 HEK-293T C11(1.01); C163(0.98)  LDD0830  [9]
 LDCM0233  AC116 HEK-293T C11(0.99); C163(0.89)  LDD0831  [9]
 LDCM0234  AC117 HEK-293T C11(0.92); C163(0.99)  LDD0832  [9]
 LDCM0235  AC118 HEK-293T C11(1.04); C163(1.04)  LDD0833  [9]
 LDCM0236  AC119 HEK-293T C11(1.04); C163(0.95)  LDD0834  [9]
 LDCM0237  AC12 HEK-293T C11(1.08); C163(1.03)  LDD0835  [9]
 LDCM0238  AC120 HEK-293T C11(0.94); C163(1.00)  LDD0836  [9]
 LDCM0239  AC121 HEK-293T C11(1.01); C163(1.11)  LDD0837  [9]
 LDCM0240  AC122 HEK-293T C11(1.16); C163(1.14)  LDD0838  [9]
 LDCM0241  AC123 HEK-293T C11(1.23); C163(1.26)  LDD0839  [9]
 LDCM0242  AC124 HEK-293T C11(0.99); C163(1.00)  LDD0840  [9]
 LDCM0243  AC125 HEK-293T C11(1.02); C163(1.17)  LDD0841  [9]
 LDCM0244  AC126 HEK-293T C11(1.31); C163(1.40)  LDD0842  [9]
 LDCM0245  AC127 HEK-293T C11(1.50); C163(1.64)  LDD0843  [9]
 LDCM0246  AC128 HEK-293T C11(1.08); C163(0.79)  LDD0844  [9]
 LDCM0247  AC129 HEK-293T C11(1.06); C163(1.46)  LDD0845  [9]
 LDCM0249  AC130 HEK-293T C11(1.09); C163(1.08)  LDD0847  [9]
 LDCM0250  AC131 HEK-293T C11(1.03); C163(1.60)  LDD0848  [9]
 LDCM0251  AC132 HEK-293T C11(0.96); C163(1.12)  LDD0849  [9]
 LDCM0252  AC133 HEK-293T C11(1.07); C163(1.72)  LDD0850  [9]
 LDCM0253  AC134 HEK-293T C11(1.03); C163(1.72)  LDD0851  [9]
 LDCM0254  AC135 HEK-293T C11(1.07); C163(1.38)  LDD0852  [9]
 LDCM0255  AC136 HEK-293T C11(1.04); C163(1.12)  LDD0853  [9]
 LDCM0256  AC137 HEK-293T C11(1.20); C163(1.79)  LDD0854  [9]
 LDCM0257  AC138 HEK-293T C11(1.52); C163(1.80)  LDD0855  [9]
 LDCM0258  AC139 HEK-293T C11(1.27); C163(1.91)  LDD0856  [9]
 LDCM0259  AC14 HEK-293T C11(1.00); C163(0.98)  LDD0857  [9]
 LDCM0260  AC140 HEK-293T C11(1.12); C163(1.11)  LDD0858  [9]
 LDCM0261  AC141 HEK-293T C11(1.22); C163(2.55)  LDD0859  [9]
 LDCM0262  AC142 HEK-293T C11(1.14); C163(1.97)  LDD0860  [9]
 LDCM0263  AC143 HEK-293T C11(1.06)  LDD0861  [9]
 LDCM0264  AC144 HEK-293T C11(1.30)  LDD0862  [9]
 LDCM0265  AC145 HEK-293T C11(1.19)  LDD0863  [9]
 LDCM0266  AC146 HEK-293T C11(1.23)  LDD0864  [9]
 LDCM0267  AC147 HEK-293T C11(1.29)  LDD0865  [9]
 LDCM0268  AC148 HEK-293T C11(1.15)  LDD0866  [9]
 LDCM0269  AC149 HEK-293T C11(0.99)  LDD0867  [9]
 LDCM0270  AC15 HEK-293T C11(1.08); C163(0.97)  LDD0868  [9]
 LDCM0271  AC150 HEK-293T C11(1.08)  LDD0869  [9]
 LDCM0272  AC151 HEK-293T C11(1.17)  LDD0870  [9]
 LDCM0273  AC152 HEK-293T C11(1.13)  LDD0871  [9]
 LDCM0274  AC153 HEK-293T C11(1.11)  LDD0872  [9]
 LDCM0621  AC154 HEK-293T C11(1.04)  LDD2162  [9]
 LDCM0622  AC155 HEK-293T C11(1.06)  LDD2163  [9]
 LDCM0623  AC156 HEK-293T C11(1.25)  LDD2164  [9]
 LDCM0624  AC157 HEK-293T C11(1.36)  LDD2165  [9]
 LDCM0279  AC2 HEK-293T C11(1.06)  LDD0877  [9]
 LDCM0285  AC25 HEK-293T C11(0.91)  LDD0883  [9]
 LDCM0286  AC26 HEK-293T C11(1.05)  LDD0884  [9]
 LDCM0287  AC27 HEK-293T C11(0.76)  LDD0885  [9]
 LDCM0288  AC28 HEK-293T C11(0.87)  LDD0886  [9]
 LDCM0289  AC29 HEK-293T C11(1.09)  LDD0887  [9]
 LDCM0290  AC3 HEK-293T C11(1.16)  LDD0888  [9]
 LDCM0291  AC30 HEK-293T C11(0.86)  LDD0889  [9]
 LDCM0292  AC31 HEK-293T C11(0.93)  LDD0890  [9]
 LDCM0293  AC32 HEK-293T C11(1.05)  LDD0891  [9]
 LDCM0294  AC33 HEK-293T C11(1.06)  LDD0892  [9]
 LDCM0295  AC34 HEK-293T C11(0.87)  LDD0893  [9]
 LDCM0296  AC35 HEK-293T C163(1.10)  LDD0894  [9]
 LDCM0297  AC36 HEK-293T C163(1.24)  LDD0895  [9]
 LDCM0298  AC37 HEK-293T C163(1.04)  LDD0896  [9]
 LDCM0299  AC38 HEK-293T C163(1.00)  LDD0897  [9]
 LDCM0300  AC39 HEK-293T C163(1.42)  LDD0898  [9]
 LDCM0301  AC4 HEK-293T C11(1.08)  LDD0899  [9]
 LDCM0302  AC40 HEK-293T C163(1.04)  LDD0900  [9]
 LDCM0303  AC41 HEK-293T C163(1.21)  LDD0901  [9]
 LDCM0304  AC42 HEK-293T C163(1.09)  LDD0902  [9]
 LDCM0305  AC43 HEK-293T C163(1.35)  LDD0903  [9]
 LDCM0306  AC44 HEK-293T C163(1.19)  LDD0904  [9]
 LDCM0307  AC45 HEK-293T C163(1.02)  LDD0905  [9]
 LDCM0308  AC46 HEK-293T C11(0.99)  LDD0906  [9]
 LDCM0309  AC47 HEK-293T C11(1.00)  LDD0907  [9]
 LDCM0310  AC48 HEK-293T C11(1.01)  LDD0908  [9]
 LDCM0311  AC49 HEK-293T C11(0.92)  LDD0909  [9]
 LDCM0312  AC5 HEK-293T C11(1.05)  LDD0910  [9]
 LDCM0313  AC50 HEK-293T C11(0.96)  LDD0911  [9]
 LDCM0314  AC51 HEK-293T C11(0.91)  LDD0912  [9]
 LDCM0315  AC52 HEK-293T C11(0.93)  LDD0913  [9]
 LDCM0316  AC53 HEK-293T C11(0.87)  LDD0914  [9]
 LDCM0317  AC54 HEK-293T C11(0.95)  LDD0915  [9]
 LDCM0318  AC55 HEK-293T C11(0.93)  LDD0916  [9]
 LDCM0319  AC56 HEK-293T C11(0.97)  LDD0917  [9]
 LDCM0320  AC57 HEK-293T C11(1.08)  LDD0918  [9]
 LDCM0321  AC58 HEK-293T C11(1.03)  LDD0919  [9]
 LDCM0322  AC59 HEK-293T C11(1.08)  LDD0920  [9]
 LDCM0323  AC6 HEK-293T C11(1.10); C163(0.97)  LDD0921  [9]
 LDCM0324  AC60 HEK-293T C11(0.98)  LDD0922  [9]
 LDCM0325  AC61 HEK-293T C11(0.93)  LDD0923  [9]
 LDCM0326  AC62 HEK-293T C11(0.99)  LDD0924  [9]
 LDCM0327  AC63 HEK-293T C11(1.12)  LDD0925  [9]
 LDCM0328  AC64 HEK-293T C11(0.94)  LDD0926  [9]
 LDCM0329  AC65 HEK-293T C11(0.99)  LDD0927  [9]
 LDCM0330  AC66 HEK-293T C11(0.94)  LDD0928  [9]
 LDCM0331  AC67 HEK-293T C11(1.05)  LDD0929  [9]
 LDCM0332  AC68 HEK-293T C11(0.90); C163(1.19)  LDD0930  [9]
 LDCM0333  AC69 HEK-293T C11(0.86); C163(1.72)  LDD0931  [9]
 LDCM0334  AC7 HEK-293T C11(1.06); C163(0.99)  LDD0932  [9]
 LDCM0335  AC70 HEK-293T C11(0.99); C163(1.29)  LDD0933  [9]
 LDCM0336  AC71 HEK-293T C11(0.91); C163(1.33)  LDD0934  [9]
 LDCM0337  AC72 HEK-293T C11(0.88); C163(1.29)  LDD0935  [9]
 LDCM0338  AC73 HEK-293T C11(0.78); C163(0.99)  LDD0936  [9]
 LDCM0339  AC74 HEK-293T C11(0.83); C163(1.46)  LDD0937  [9]
 LDCM0340  AC75 HEK-293T C11(0.81); C163(1.16)  LDD0938  [9]
 LDCM0341  AC76 HEK-293T C11(0.94); C163(1.26)  LDD0939  [9]
 LDCM0342  AC77 HEK-293T C11(1.01); C163(1.08)  LDD0940  [9]
 LDCM0343  AC78 HEK-293T C11(0.78); C163(1.34)  LDD0941  [9]
 LDCM0344  AC79 HEK-293T C11(0.87); C163(1.36)  LDD0942  [9]
 LDCM0345  AC8 HEK-293T C11(1.06); C163(1.11)  LDD0943  [9]
 LDCM0346  AC80 HEK-293T C11(0.92); C163(1.52)  LDD0944  [9]
 LDCM0347  AC81 HEK-293T C11(0.91); C163(1.02)  LDD0945  [9]
 LDCM0348  AC82 HEK-293T C11(0.92); C163(1.22)  LDD0946  [9]
 LDCM0365  AC98 HEK-293T C11(0.95); C163(1.00)  LDD0963  [9]
 LDCM0366  AC99 HEK-293T C11(0.93); C163(0.85)  LDD0964  [9]
 LDCM0248  AKOS034007472 HEK-293T C11(0.96); C163(0.98)  LDD0846  [9]
 LDCM0356  AKOS034007680 HEK-293T C11(0.99); C163(1.05)  LDD0954  [9]
 LDCM0275  AKOS034007705 HEK-293T C11(1.05); C163(1.03)  LDD0873  [9]
 LDCM0156  Aniline NCI-H1299 11.78  LDD0403  [1]
 LDCM0369  CL100 HEK-293T C11(1.11)  LDD0967  [9]
 LDCM0370  CL101 HEK-293T C11(0.96); C163(1.02)  LDD0968  [9]
 LDCM0371  CL102 HEK-293T C11(1.00); C163(1.15)  LDD0969  [9]
 LDCM0372  CL103 HEK-293T C11(0.98); C163(1.10)  LDD0970  [9]
 LDCM0373  CL104 HEK-293T C11(0.99); C163(1.08)  LDD0971  [9]
 LDCM0382  CL112 HEK-293T C11(0.78)  LDD0980  [9]
 LDCM0383  CL113 HEK-293T C11(0.97)  LDD0981  [9]
 LDCM0384  CL114 HEK-293T C11(0.84)  LDD0982  [9]
 LDCM0385  CL115 HEK-293T C11(0.97)  LDD0983  [9]
 LDCM0386  CL116 HEK-293T C11(1.05)  LDD0984  [9]
 LDCM0387  CL117 HEK-293T C163(0.94)  LDD0985  [9]
 LDCM0388  CL118 HEK-293T C163(1.23)  LDD0986  [9]
 LDCM0389  CL119 HEK-293T C163(1.35)  LDD0987  [9]
 LDCM0391  CL120 HEK-293T C163(1.37)  LDD0989  [9]
 LDCM0392  CL121 HEK-293T C11(0.89)  LDD0990  [9]
 LDCM0393  CL122 HEK-293T C11(0.92)  LDD0991  [9]
 LDCM0394  CL123 HEK-293T C11(0.89)  LDD0992  [9]
 LDCM0395  CL124 HEK-293T C11(0.83)  LDD0993  [9]
 LDCM0396  CL125 HEK-293T C11(1.09)  LDD0994  [9]
 LDCM0397  CL126 HEK-293T C11(1.03)  LDD0995  [9]
 LDCM0398  CL127 HEK-293T C11(1.13)  LDD0996  [9]
 LDCM0399  CL128 HEK-293T C11(1.14)  LDD0997  [9]
 LDCM0403  CL16 HEK-293T C163(0.88)  LDD1001  [9]
 LDCM0404  CL17 HEK-293T C163(0.88)  LDD1002  [9]
 LDCM0405  CL18 HEK-293T C163(1.05)  LDD1003  [9]
 LDCM0406  CL19 HEK-293T C163(0.99)  LDD1004  [9]
 LDCM0408  CL20 HEK-293T C163(1.04)  LDD1006  [9]
 LDCM0409  CL21 HEK-293T C163(0.92)  LDD1007  [9]
 LDCM0410  CL22 HEK-293T C163(0.94)  LDD1008  [9]
 LDCM0411  CL23 HEK-293T C163(1.00)  LDD1009  [9]
 LDCM0412  CL24 HEK-293T C163(0.95)  LDD1010  [9]
 LDCM0413  CL25 HEK-293T C163(0.94)  LDD1011  [9]
 LDCM0414  CL26 HEK-293T C163(0.90)  LDD1012  [9]
 LDCM0415  CL27 HEK-293T C163(0.90)  LDD1013  [9]
 LDCM0416  CL28 HEK-293T C163(0.84)  LDD1014  [9]
 LDCM0417  CL29 HEK-293T C163(0.89)  LDD1015  [9]
 LDCM0419  CL30 HEK-293T C163(1.09)  LDD1017  [9]
 LDCM0420  CL31 HEK-293T C11(0.83); C163(0.94)  LDD1018  [9]
 LDCM0421  CL32 HEK-293T C11(0.84); C163(1.17)  LDD1019  [9]
 LDCM0422  CL33 HEK-293T C11(0.84); C163(0.97)  LDD1020  [9]
 LDCM0423  CL34 HEK-293T C11(0.79); C163(0.99)  LDD1021  [9]
 LDCM0424  CL35 HEK-293T C11(0.79); C163(1.12)  LDD1022  [9]
 LDCM0425  CL36 HEK-293T C11(0.87); C163(0.96)  LDD1023  [9]
 LDCM0426  CL37 HEK-293T C11(0.90); C163(0.77)  LDD1024  [9]
 LDCM0428  CL39 HEK-293T C11(0.97); C163(1.29)  LDD1026  [9]
 LDCM0430  CL40 HEK-293T C11(0.77); C163(0.89)  LDD1028  [9]
 LDCM0431  CL41 HEK-293T C11(0.93); C163(0.99)  LDD1029  [9]
 LDCM0432  CL42 HEK-293T C11(0.89); C163(1.24)  LDD1030  [9]
 LDCM0433  CL43 HEK-293T C11(1.03); C163(1.15)  LDD1031  [9]
 LDCM0434  CL44 HEK-293T C11(0.92); C163(0.93)  LDD1032  [9]
 LDCM0435  CL45 HEK-293T C11(0.99); C163(1.09)  LDD1033  [9]
 LDCM0436  CL46 HEK-293T C163(1.00)  LDD1034  [9]
 LDCM0437  CL47 HEK-293T C163(0.96)  LDD1035  [9]
 LDCM0438  CL48 HEK-293T C163(1.13)  LDD1036  [9]
 LDCM0439  CL49 HEK-293T C163(0.91)  LDD1037  [9]
 LDCM0441  CL50 HEK-293T C163(1.24)  LDD1039  [9]
 LDCM0442  CL51 HEK-293T C163(0.95)  LDD1040  [9]
 LDCM0443  CL52 HEK-293T C163(1.08)  LDD1041  [9]
 LDCM0444  CL53 HEK-293T C163(1.08)  LDD1042  [9]
 LDCM0445  CL54 HEK-293T C163(1.02)  LDD1043  [9]
 LDCM0446  CL55 HEK-293T C163(1.04)  LDD1044  [9]
 LDCM0447  CL56 HEK-293T C163(1.01)  LDD1045  [9]
 LDCM0448  CL57 HEK-293T C163(0.97)  LDD1046  [9]
 LDCM0449  CL58 HEK-293T C163(1.08)  LDD1047  [9]
 LDCM0450  CL59 HEK-293T C163(1.05)  LDD1048  [9]
 LDCM0452  CL60 HEK-293T C163(1.15)  LDD1050  [9]
 LDCM0486  CL91 HEK-293T C11(1.06)  LDD1084  [9]
 LDCM0487  CL92 HEK-293T C11(1.08)  LDD1085  [9]
 LDCM0488  CL93 HEK-293T C11(1.07)  LDD1086  [9]
 LDCM0489  CL94 HEK-293T C11(1.07)  LDD1087  [9]
 LDCM0490  CL95 HEK-293T C11(1.00)  LDD1088  [9]
 LDCM0491  CL96 HEK-293T C11(0.97)  LDD1089  [9]
 LDCM0492  CL97 HEK-293T C11(1.03)  LDD1090  [9]
 LDCM0493  CL98 HEK-293T C11(1.07)  LDD1091  [9]
 LDCM0494  CL99 HEK-293T C11(1.20)  LDD1092  [9]
 LDCM0427  Fragment51 HEK-293T C11(0.77); C163(0.81)  LDD1025  [9]
 LDCM0022  KB02 HEK-293T C163(0.83)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C163(0.96)  LDD1497  [10]
 LDCM0024  KB05 HMCB C11(1.16)  LDD3312  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Multiple PDZ domain protein (MPDZ) . O75970
SH3 domain-binding protein 4 (SH3BP4) . Q9P0V3

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Citric Acid Small molecular drug DB04272

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402