Details of the Target

General Information of Target

Target ID LDTP12087
Target Name CCR4-NOT transcription complex subunit 10 (CNOT10)
Gene Name CNOT10
Gene ID 25904
Synonyms
CCR4-NOT transcription complex subunit 10
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKIKDAKKPSFPWFGMDIGGTLVKLSYFEPIDITAEEEQEEVESLKSIRKYLTSNVAYGS
TGIRDVHLELKDLTLFGRRGNLHFIRFPTQDLPTFIQMGRDKNFSTLQTVLCATGGGAYK
FEKDFRTIGNLHLHKLDELDCLVKGLLYIDSVSFNGQAECYYFANASEPERCQKMPFNLD
DPYPLLVVNIGSGVSILAVHSKDNYKRVTGTSLGGGTFLGLCSLLTGCESFEEALEMASK
GDSTQADKLVRDIYGGDYERFGLPGWAVASSFGNMIYKEKRESVSKEDLARATLVTITNN
IGSVARMCAVNEKINRVVFVGNFLRVNTLSMKLLAYALDYWSKGQLKALFLEHEGYFGAV
GALLGLPNFS
Target Bioclass
Other
Family
CNOT10 family
Subcellular location
Cytoplasm
Function
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex.
Uniprot ID
Q9H9A5
Ensemble ID
ENST00000328834.10
HGNC ID
HGNC:23817
ChEMBL ID
CHEMBL4105878

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A101D SNV: p.G694S DBIA    Probe Info 
HCT15 SNV: p.R629W .
HEC1 SNV: p.C327Y DBIA    Probe Info 
HEC1B SNV: p.C327Y .
NCIH2172 SNV: p.R292I DBIA    Probe Info 
RL952 SNV: p.V638I DBIA    Probe Info 
YSCCC SNV: p.Ter745SextTer20 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K713(0.75)  LDD0277  [2]
DBIA
 Probe Info  		C693(4.06)  LDD3311  [3]
BTD
 Probe Info  		C347(0.83); C633(0.87)  LDD2099  [4]
AHL-Pu-1
 Probe Info  		C504(2.28)  LDD0168  [5]
ATP probe
 Probe Info  		K713(0.00); K513(0.00); K240(0.00)  LDD0199  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C633(0.00); C504(0.00); C654(0.00); C665(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C327(0.00); C633(0.00); C504(0.00); C533(0.00)  LDD0036  [7]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [8]
Lodoacetamide azide
 Probe Info  		C327(0.00); C633(0.00); C665(0.00); C347(0.00)  LDD0037  [7]
TFBX
 Probe Info  		N.A.  LDD0027  [9]
ENE
 Probe Info  		N.A.  LDD0006  [10]
IPM
 Probe Info  		C633(0.00); C290(0.00)  LDD0005  [10]
VSF
 Probe Info  		N.A.  LDD0007  [10]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [11]
1d-yne
 Probe Info  		N.A.  LDD0357  [12]
Acrolein
 Probe Info  		N.A.  LDD0217  [13]
Methacrolein
 Probe Info  		N.A.  LDD0218  [13]
AOyne
 Probe Info  		12.20  LDD0443  [14]
NAIA_5
 Probe Info  		C347(0.00); C665(0.00); C633(0.00); C654(0.00)  LDD2223  [15]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C347(1.01); C633(0.91)  LDD2117  [4]
 LDCM0025  4SU-RNA HEK-293T C504(2.28)  LDD0168  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C504(2.42)  LDD0169  [5]
 LDCM0214  AC1 HEK-293T C633(1.02); C504(1.17); C347(0.86); C654(1.02)  LDD1507  [17]
 LDCM0215  AC10 HEK-293T C633(1.03); C504(1.08); C347(0.99); C654(1.04)  LDD1508  [17]
 LDCM0226  AC11 HEK-293T C633(1.18); C504(1.02); C347(1.09); C327(1.01)  LDD1509  [17]
 LDCM0237  AC12 HEK-293T C633(0.98); C504(1.08); C347(1.03); C654(1.03)  LDD1510  [17]
 LDCM0259  AC14 HEK-293T C633(1.00); C504(1.06); C347(1.09); C654(0.80)  LDD1512  [17]
 LDCM0270  AC15 HEK-293T C633(0.97); C347(1.11); C327(0.97); C293(1.02)  LDD1513  [17]
 LDCM0276  AC17 HEK-293T C633(0.89); C504(1.14); C347(0.83); C654(0.89)  LDD1515  [17]
 LDCM0277  AC18 HEK-293T C633(1.00); C504(0.98); C347(1.01); C654(0.89)  LDD1516  [17]
 LDCM0278  AC19 HEK-293T C633(1.03); C504(1.07); C347(0.91); C327(1.06)  LDD1517  [17]
 LDCM0279  AC2 HEK-293T C633(1.01); C504(0.96); C347(1.12); C654(1.03)  LDD1518  [17]
 LDCM0280  AC20 HEK-293T C633(0.83); C504(0.99); C347(0.95); C654(0.84)  LDD1519  [17]
 LDCM0281  AC21 HEK-293T C633(0.96); C504(0.97); C654(0.94); C665(0.96)  LDD1520  [17]
 LDCM0282  AC22 HEK-293T C633(1.06); C504(0.93); C347(1.05); C654(0.72)  LDD1521  [17]
 LDCM0283  AC23 HEK-293T C633(0.98); C347(1.05); C327(0.83); C293(1.08)  LDD1522  [17]
 LDCM0284  AC24 HEK-293T C633(1.29); C504(0.98); C347(0.93); C665(1.07)  LDD1523  [17]
 LDCM0285  AC25 HEK-293T C633(0.90); C504(1.10); C347(0.75); C654(0.98)  LDD1524  [17]
 LDCM0286  AC26 HEK-293T C633(0.97); C504(0.97); C347(0.92); C654(1.09)  LDD1525  [17]
 LDCM0287  AC27 HEK-293T C633(1.16); C504(1.11); C347(1.06); C327(1.03)  LDD1526  [17]
 LDCM0288  AC28 HEK-293T C633(0.97); C504(0.98); C347(1.08); C654(0.84)  LDD1527  [17]
 LDCM0289  AC29 HEK-293T C633(0.99); C504(1.05); C654(1.01); C665(0.99)  LDD1528  [17]
 LDCM0290  AC3 HEK-293T C633(1.11); C504(0.93); C347(0.96); C327(1.02)  LDD1529  [17]
 LDCM0291  AC30 HEK-293T C633(1.12); C504(0.97); C347(0.95); C654(0.86)  LDD1530  [17]
 LDCM0292  AC31 HEK-293T C633(1.09); C347(1.09); C327(0.85); C293(1.02)  LDD1531  [17]
 LDCM0293  AC32 HEK-293T C633(1.41); C504(0.97); C347(0.82); C665(0.99)  LDD1532  [17]
 LDCM0294  AC33 HEK-293T C633(0.94); C504(1.18); C347(0.86); C654(1.10)  LDD1533  [17]
 LDCM0295  AC34 HEK-293T C633(0.93); C504(1.01); C347(1.14); C654(1.12)  LDD1534  [17]
 LDCM0296  AC35 HEK-293T C633(1.12); C504(1.09); C347(1.10); C327(1.29)  LDD1535  [17]
 LDCM0297  AC36 HEK-293T C633(1.03); C504(1.30); C347(1.04); C654(1.04)  LDD1536  [17]
 LDCM0298  AC37 HEK-293T C633(1.00); C504(1.06); C654(0.91); C665(1.04)  LDD1537  [17]
 LDCM0299  AC38 HEK-293T C633(1.01); C504(1.21); C347(1.03); C654(0.78)  LDD1538  [17]
 LDCM0300  AC39 HEK-293T C633(0.98); C347(1.04); C327(0.89); C293(0.83)  LDD1539  [17]
 LDCM0301  AC4 HEK-293T C633(1.12); C504(1.01); C347(0.94); C654(1.25)  LDD1540  [17]
 LDCM0302  AC40 HEK-293T C633(1.31); C504(0.97); C347(0.78); C665(0.99)  LDD1541  [17]
 LDCM0303  AC41 HEK-293T C633(0.96); C504(1.23); C347(0.96); C654(0.91)  LDD1542  [17]
 LDCM0304  AC42 HEK-293T C633(0.99); C504(1.05); C347(0.98); C654(1.06)  LDD1543  [17]
 LDCM0305  AC43 HEK-293T C633(1.04); C504(1.11); C347(1.04); C327(0.94)  LDD1544  [17]
 LDCM0306  AC44 HEK-293T C633(1.00); C504(1.05); C347(1.08); C654(1.07)  LDD1545  [17]
 LDCM0307  AC45 HEK-293T C633(0.99); C504(1.16); C654(0.95); C665(1.10)  LDD1546  [17]
 LDCM0308  AC46 HEK-293T C633(1.06); C504(1.15); C347(1.10); C654(1.00)  LDD1547  [17]
 LDCM0309  AC47 HEK-293T C633(1.02); C347(0.96); C327(0.95); C293(1.30)  LDD1548  [17]
 LDCM0310  AC48 HEK-293T C633(1.27); C504(0.93); C347(0.84); C665(1.12)  LDD1549  [17]
 LDCM0311  AC49 HEK-293T C633(0.88); C504(1.25); C347(1.03); C654(0.99)  LDD1550  [17]
 LDCM0312  AC5 HEK-293T C633(0.94); C504(1.13); C654(0.86); C665(1.03)  LDD1551  [17]
 LDCM0313  AC50 HEK-293T C633(1.08); C504(1.17); C347(1.04); C654(1.05)  LDD1552  [17]
 LDCM0314  AC51 HEK-293T C633(1.06); C504(1.10); C347(1.10); C327(1.06)  LDD1553  [17]
 LDCM0315  AC52 HEK-293T C633(0.97); C504(0.97); C347(1.11); C654(1.01)  LDD1554  [17]
 LDCM0316  AC53 HEK-293T C633(0.98); C504(1.09); C654(1.02); C665(1.04)  LDD1555  [17]
 LDCM0317  AC54 HEK-293T C633(1.08); C504(1.12); C347(1.13); C654(1.07)  LDD1556  [17]
 LDCM0318  AC55 HEK-293T C633(0.94); C347(1.01); C327(0.96); C293(1.01)  LDD1557  [17]
 LDCM0319  AC56 HEK-293T C633(1.30); C504(1.19); C347(0.97); C665(0.96)  LDD1558  [17]
 LDCM0320  AC57 HEK-293T C633(0.90); C504(1.09); C347(0.93); C654(1.13)  LDD1559  [17]
 LDCM0321  AC58 HEK-293T C633(1.04); C504(1.01); C347(1.05); C654(1.02)  LDD1560  [17]
 LDCM0322  AC59 HEK-293T C633(1.16); C504(0.93); C347(1.08); C327(1.12)  LDD1561  [17]
 LDCM0323  AC6 HEK-293T C633(1.11); C504(1.13); C347(0.98); C654(0.87)  LDD1562  [17]
 LDCM0324  AC60 HEK-293T C633(0.94); C504(1.14); C347(0.93); C654(1.14)  LDD1563  [17]
 LDCM0325  AC61 HEK-293T C633(0.95); C504(1.19); C654(0.99); C665(0.95)  LDD1564  [17]
 LDCM0326  AC62 HEK-293T C633(1.07); C504(1.00); C347(1.00); C654(0.89)  LDD1565  [17]
 LDCM0327  AC63 HEK-293T C633(1.05); C347(0.97); C327(0.88); C293(0.94)  LDD1566  [17]
 LDCM0328  AC64 HEK-293T C633(1.28); C504(0.99); C347(0.95); C665(0.98)  LDD1567  [17]
 LDCM0334  AC7 HEK-293T C633(1.02); C347(1.09); C327(1.06); C293(0.90)  LDD1568  [17]
 LDCM0345  AC8 HEK-293T C633(1.38); C504(0.91); C347(0.87); C665(1.01)  LDD1569  [17]
 LDCM0248  AKOS034007472 HEK-293T C633(0.93); C504(1.15); C654(0.93); C665(1.00)  LDD1511  [17]
 LDCM0356  AKOS034007680 HEK-293T C633(0.89); C504(1.16); C347(1.00); C654(0.85)  LDD1570  [17]
 LDCM0275  AKOS034007705 HEK-293T C633(1.32); C504(1.08); C347(1.06); C665(1.10)  LDD1514  [17]
 LDCM0156  Aniline NCI-H1299 12.45  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [13]
 LDCM0632  CL-Sc Hep-G2 C654(20.00); C504(1.41)  LDD2227  [15]
 LDCM0367  CL1 HEK-293T C633(1.14); C504(1.10); C347(1.33); C654(0.85)  LDD1571  [17]
 LDCM0368  CL10 HEK-293T C633(0.91); C504(0.87); C347(1.81); C654(0.73)  LDD1572  [17]
 LDCM0369  CL100 HEK-293T C633(0.80); C504(1.13); C347(0.83); C654(1.11)  LDD1573  [17]
 LDCM0370  CL101 HEK-293T C633(1.21); C504(0.97); C347(0.94); C654(1.04)  LDD1574  [17]
 LDCM0371  CL102 HEK-293T C633(1.18); C504(1.04); C347(1.03); C327(1.08)  LDD1575  [17]
 LDCM0372  CL103 HEK-293T C633(1.04); C504(1.05); C347(1.10); C665(1.13)  LDD1576  [17]
 LDCM0373  CL104 HEK-293T C633(0.91); C504(1.09); C347(1.19); C654(0.85)  LDD1577  [17]
 LDCM0374  CL105 HEK-293T C633(1.18); C504(1.04); C347(0.97); C654(1.26)  LDD1578  [17]
 LDCM0375  CL106 HEK-293T C633(1.01); C504(1.09); C347(0.94); C327(1.16)  LDD1579  [17]
 LDCM0376  CL107 HEK-293T C633(0.95); C504(0.98); C347(1.04); C665(1.06)  LDD1580  [17]
 LDCM0377  CL108 HEK-293T C633(0.81); C504(1.25); C347(0.99); C654(0.80)  LDD1581  [17]
 LDCM0378  CL109 HEK-293T C633(1.14); C504(0.90); C347(0.91); C654(0.80)  LDD1582  [17]
 LDCM0379  CL11 HEK-293T C633(0.80); C347(2.09); C327(0.89); C293(0.97)  LDD1583  [17]
 LDCM0380  CL110 HEK-293T C633(1.16); C504(0.97); C347(0.88); C327(0.97)  LDD1584  [17]
 LDCM0381  CL111 HEK-293T C633(0.89); C504(0.81); C347(1.05); C665(1.04)  LDD1585  [17]
 LDCM0382  CL112 HEK-293T C633(0.82); C504(1.27); C347(0.95); C654(0.83)  LDD1586  [17]
 LDCM0383  CL113 HEK-293T C633(1.12); C504(1.04); C347(0.98); C654(1.54)  LDD1587  [17]
 LDCM0384  CL114 HEK-293T C633(1.13); C504(0.79); C347(0.93); C327(0.88)  LDD1588  [17]
 LDCM0385  CL115 HEK-293T C633(1.03); C504(0.78); C347(1.06); C665(1.07)  LDD1589  [17]
 LDCM0386  CL116 HEK-293T C633(0.99); C504(1.34); C347(0.96); C654(1.02)  LDD1590  [17]
 LDCM0387  CL117 HEK-293T C633(1.21); C504(1.04); C347(1.10); C654(1.17)  LDD1591  [17]
 LDCM0388  CL118 HEK-293T C633(1.05); C504(1.21); C347(0.88); C327(0.97)  LDD1592  [17]
 LDCM0389  CL119 HEK-293T C633(1.11); C504(0.85); C347(1.03); C665(1.08)  LDD1593  [17]
 LDCM0390  CL12 HEK-293T C633(1.15); C504(1.08); C347(1.28); C665(0.90)  LDD1594  [17]
 LDCM0391  CL120 HEK-293T C633(0.91); C504(1.11); C347(0.92); C654(1.12)  LDD1595  [17]
 LDCM0392  CL121 HEK-293T C633(1.22); C504(1.30); C347(0.95); C654(0.84)  LDD1596  [17]
 LDCM0393  CL122 HEK-293T C633(0.98); C504(1.12); C347(1.12); C327(0.99)  LDD1597  [17]
 LDCM0394  CL123 HEK-293T C633(1.03); C504(0.65); C347(0.99); C665(0.98)  LDD1598  [17]
 LDCM0395  CL124 HEK-293T C633(0.78); C504(1.34); C347(0.85); C654(0.92)  LDD1599  [17]
 LDCM0396  CL125 HEK-293T C633(1.47); C504(1.22); C347(1.01); C654(1.20)  LDD1600  [17]
 LDCM0397  CL126 HEK-293T C633(1.03); C504(0.82); C347(1.00); C327(1.10)  LDD1601  [17]
 LDCM0398  CL127 HEK-293T C633(0.91); C504(0.80); C347(1.04); C665(0.94)  LDD1602  [17]
 LDCM0399  CL128 HEK-293T C633(0.84); C504(1.03); C347(0.95); C654(1.01)  LDD1603  [17]
 LDCM0400  CL13 HEK-293T C633(1.27); C504(1.19); C347(1.21); C654(1.02)  LDD1604  [17]
 LDCM0401  CL14 HEK-293T C633(1.10); C504(1.41); C347(1.27); C327(1.10)  LDD1605  [17]
 LDCM0402  CL15 HEK-293T C633(0.88); C504(1.12); C347(1.20); C665(0.95)  LDD1606  [17]
 LDCM0403  CL16 HEK-293T C633(0.85); C504(1.11); C347(1.33); C654(0.95)  LDD1607  [17]
 LDCM0404  CL17 HEK-293T C633(0.81); C504(1.06); C347(0.21); C654(0.87)  LDD1608  [17]
 LDCM0405  CL18 HEK-293T C633(0.93); C504(1.14); C347(1.64); C654(0.95)  LDD1609  [17]
 LDCM0406  CL19 HEK-293T C633(1.08); C504(1.27); C347(1.37); C327(0.93)  LDD1610  [17]
 LDCM0407  CL2 HEK-293T C633(1.24); C504(1.00); C347(0.97); C327(1.35)  LDD1611  [17]
 LDCM0408  CL20 HEK-293T C633(0.82); C504(1.19); C347(1.74); C654(0.90)  LDD1612  [17]
 LDCM0409  CL21 HEK-293T C633(0.71); C504(1.35); C654(0.85); C665(0.93)  LDD1613  [17]
 LDCM0410  CL22 HEK-293T C633(1.00); C504(1.06); C347(2.23); C654(0.62)  LDD1614  [17]
 LDCM0411  CL23 HEK-293T C633(0.84); C347(2.56); C327(0.89); C293(0.87)  LDD1615  [17]
 LDCM0412  CL24 HEK-293T C633(1.24); C504(1.11); C347(1.66); C665(0.93)  LDD1616  [17]
 LDCM0413  CL25 HEK-293T C633(1.36); C504(0.96); C347(0.96); C654(0.56)  LDD1617  [17]
 LDCM0414  CL26 HEK-293T C633(1.02); C504(0.94); C347(0.95); C327(0.94)  LDD1618  [17]
 LDCM0415  CL27 HEK-293T C633(1.13); C504(1.10); C347(1.18); C665(1.12)  LDD1619  [17]
 LDCM0416  CL28 HEK-293T C633(0.81); C504(1.14); C347(1.07); C654(0.87)  LDD1620  [17]
 LDCM0417  CL29 HEK-293T C633(0.94); C504(1.13); C347(1.05); C654(0.88)  LDD1621  [17]
 LDCM0418  CL3 HEK-293T C633(1.01); C504(1.04); C347(1.11); C665(0.98)  LDD1622  [17]
 LDCM0419  CL30 HEK-293T C633(1.06); C504(1.01); C347(1.19); C654(0.99)  LDD1623  [17]
 LDCM0420  CL31 HEK-293T C633(1.08); C504(1.17); C347(1.25); C327(0.91)  LDD1624  [17]
 LDCM0421  CL32 HEK-293T C633(0.91); C504(1.02); C347(1.10); C654(0.84)  LDD1625  [17]
 LDCM0422  CL33 HEK-293T C633(0.74); C504(1.01); C654(0.79); C665(0.85)  LDD1626  [17]
 LDCM0423  CL34 HEK-293T C633(0.87); C504(1.26); C347(1.92); C654(0.65)  LDD1627  [17]
 LDCM0424  CL35 HEK-293T C633(0.86); C347(2.15); C327(1.08); C293(0.79)  LDD1628  [17]
 LDCM0425  CL36 HEK-293T C633(1.24); C504(1.00); C347(1.59); C665(0.93)  LDD1629  [17]
 LDCM0426  CL37 HEK-293T C633(1.50); C504(1.03); C347(1.06); C654(1.31)  LDD1630  [17]
 LDCM0428  CL39 HEK-293T C633(1.05); C504(0.92); C347(1.22); C665(0.98)  LDD1632  [17]
 LDCM0429  CL4 HEK-293T C633(0.91); C504(0.89); C347(0.94); C654(0.86)  LDD1633  [17]
 LDCM0430  CL40 HEK-293T C633(0.85); C504(1.02); C347(0.96); C654(0.84)  LDD1634  [17]
 LDCM0431  CL41 HEK-293T C633(0.88); C504(1.10); C347(0.79); C654(0.88)  LDD1635  [17]
 LDCM0432  CL42 HEK-293T C633(1.16); C504(0.94); C347(1.36); C654(0.92)  LDD1636  [17]
 LDCM0433  CL43 HEK-293T C633(1.10); C504(1.15); C347(1.26); C327(1.07)  LDD1637  [17]
 LDCM0434  CL44 HEK-293T C633(1.05); C504(0.95); C347(1.24); C654(0.99)  LDD1638  [17]
 LDCM0435  CL45 HEK-293T C633(0.85); C504(1.14); C654(0.81); C665(0.92)  LDD1639  [17]
 LDCM0436  CL46 HEK-293T C633(0.96); C504(1.03); C347(2.28); C654(0.67)  LDD1640  [17]
 LDCM0437  CL47 HEK-293T C633(0.90); C347(1.77); C327(0.86); C293(0.75)  LDD1641  [17]
 LDCM0438  CL48 HEK-293T C633(1.47); C504(1.06); C347(1.59); C665(0.91)  LDD1642  [17]
 LDCM0439  CL49 HEK-293T C633(1.37); C504(1.07); C347(1.00); C654(1.30)  LDD1643  [17]
 LDCM0440  CL5 HEK-293T C633(0.91); C504(1.28); C347(0.88); C654(0.86)  LDD1644  [17]
 LDCM0441  CL50 HEK-293T C633(1.09); C504(0.80); C347(0.95); C327(0.82)  LDD1645  [17]
 LDCM0443  CL52 HEK-293T C633(0.96); C504(1.20); C347(1.03); C654(0.94)  LDD1646  [17]
 LDCM0444  CL53 HEK-293T C633(0.88); C504(1.03); C347(0.82); C654(0.80)  LDD1647  [17]
 LDCM0445  CL54 HEK-293T C633(0.91); C504(1.05); C347(1.19); C654(0.97)  LDD1648  [17]
 LDCM0446  CL55 HEK-293T C633(1.12); C504(1.11); C347(1.29); C327(0.87)  LDD1649  [17]
 LDCM0447  CL56 HEK-293T C633(0.93); C504(1.11); C347(1.24); C654(0.87)  LDD1650  [17]
 LDCM0448  CL57 HEK-293T C633(0.83); C504(1.23); C654(0.77); C665(0.92)  LDD1651  [17]
 LDCM0449  CL58 HEK-293T C633(0.91); C504(1.18); C347(2.07); C654(0.80)  LDD1652  [17]
 LDCM0450  CL59 HEK-293T C633(0.92); C347(1.89); C327(0.82); C293(0.71)  LDD1653  [17]
 LDCM0451  CL6 HEK-293T C633(0.92); C504(0.93); C347(1.27); C654(0.89)  LDD1654  [17]
 LDCM0452  CL60 HEK-293T C633(1.19); C504(1.13); C347(1.33); C665(1.00)  LDD1655  [17]
 LDCM0453  CL61 HEK-293T C633(1.65); C504(0.80); C347(1.10); C654(1.12)  LDD1656  [17]
 LDCM0454  CL62 HEK-293T C633(1.03); C504(1.00); C347(0.99); C327(0.83)  LDD1657  [17]
 LDCM0455  CL63 HEK-293T C633(0.97); C504(0.90); C347(1.10); C665(1.07)  LDD1658  [17]
 LDCM0456  CL64 HEK-293T C633(0.88); C504(1.23); C347(1.01); C654(0.89)  LDD1659  [17]
 LDCM0457  CL65 HEK-293T C633(0.97); C504(1.23); C347(0.91); C654(0.97)  LDD1660  [17]
 LDCM0458  CL66 HEK-293T C633(1.04); C504(1.06); C347(1.22); C654(0.91)  LDD1661  [17]
 LDCM0459  CL67 HEK-293T C633(1.14); C504(1.04); C347(1.20); C327(0.87)  LDD1662  [17]
 LDCM0460  CL68 HEK-293T C633(0.98); C504(1.05); C347(1.30); C654(1.00)  LDD1663  [17]
 LDCM0461  CL69 HEK-293T C633(0.88); C504(1.04); C654(0.84); C665(0.99)  LDD1664  [17]
 LDCM0462  CL7 HEK-293T C633(1.09); C504(1.20); C347(1.13); C327(1.04)  LDD1665  [17]
 LDCM0463  CL70 HEK-293T C633(0.97); C504(1.28); C347(1.87); C654(0.71)  LDD1666  [17]
 LDCM0464  CL71 HEK-293T C633(0.94); C347(1.68); C327(1.00); C293(0.83)  LDD1667  [17]
 LDCM0465  CL72 HEK-293T C633(1.24); C504(1.05); C347(1.49); C665(0.92)  LDD1668  [17]
 LDCM0466  CL73 HEK-293T C633(1.39); C504(0.97); C347(0.80); C654(1.42)  LDD1669  [17]
 LDCM0467  CL74 HEK-293T C633(1.25); C504(1.26); C347(1.00); C327(1.34)  LDD1670  [17]
 LDCM0469  CL76 HEK-293T C633(0.80); C504(1.22); C347(0.90); C654(0.94)  LDD1672  [17]
 LDCM0470  CL77 HEK-293T C633(0.88); C504(1.25); C347(0.88); C654(0.78)  LDD1673  [17]
 LDCM0471  CL78 HEK-293T C633(1.04); C504(0.94); C347(1.17); C654(1.00)  LDD1674  [17]
 LDCM0472  CL79 HEK-293T C633(1.11); C504(1.10); C347(1.19); C327(0.88)  LDD1675  [17]
 LDCM0473  CL8 HEK-293T C633(0.77); C504(0.74); C347(1.50); C654(0.89)  LDD1676  [17]
 LDCM0474  CL80 HEK-293T C633(1.04); C504(1.20); C347(1.42); C654(1.02)  LDD1677  [17]
 LDCM0475  CL81 HEK-293T C633(0.89); C504(1.34); C654(0.84); C665(0.99)  LDD1678  [17]
 LDCM0476  CL82 HEK-293T C633(1.01); C504(1.21); C347(1.50); C654(0.69)  LDD1679  [17]
 LDCM0477  CL83 HEK-293T C633(0.95); C347(1.38); C327(0.93); C293(1.04)  LDD1680  [17]
 LDCM0478  CL84 HEK-293T C633(1.20); C504(1.01); C347(1.24); C665(0.88)  LDD1681  [17]
 LDCM0479  CL85 HEK-293T C633(1.83); C504(1.15); C347(1.12); C654(1.21)  LDD1682  [17]
 LDCM0480  CL86 HEK-293T C633(1.14); C504(0.81); C347(0.95); C327(1.58)  LDD1683  [17]
 LDCM0481  CL87 HEK-293T C633(0.98); C504(0.76); C347(1.12); C665(0.96)  LDD1684  [17]
 LDCM0482  CL88 HEK-293T C633(0.83); C504(1.05); C347(1.04); C654(1.04)  LDD1685  [17]
 LDCM0483  CL89 HEK-293T C633(1.15); C504(1.11); C347(1.08); C654(0.93)  LDD1686  [17]
 LDCM0484  CL9 HEK-293T C633(0.84); C504(1.08); C654(0.92); C665(0.95)  LDD1687  [17]
 LDCM0485  CL90 HEK-293T C633(0.90); C504(0.75); C347(1.18); C654(0.89)  LDD1688  [17]
 LDCM0486  CL91 HEK-293T C633(1.29); C504(1.02); C347(1.33); C327(0.91)  LDD1689  [17]
 LDCM0487  CL92 HEK-293T C633(1.01); C504(0.98); C347(1.27); C654(1.12)  LDD1690  [17]
 LDCM0488  CL93 HEK-293T C633(0.89); C504(0.96); C654(0.88); C665(0.90)  LDD1691  [17]
 LDCM0489  CL94 HEK-293T C633(1.02); C504(1.15); C347(1.53); C654(0.78)  LDD1692  [17]
 LDCM0490  CL95 HEK-293T C633(1.04); C347(1.05); C327(0.74); C293(0.81)  LDD1693  [17]
 LDCM0491  CL96 HEK-293T C633(1.51); C504(0.95); C347(1.06); C665(0.83)  LDD1694  [17]
 LDCM0492  CL97 HEK-293T C633(1.35); C504(0.84); C347(1.04); C654(1.33)  LDD1695  [17]
 LDCM0493  CL98 HEK-293T C633(1.15); C504(1.00); C347(1.01); C327(0.98)  LDD1696  [17]
 LDCM0494  CL99 HEK-293T C633(1.01); C504(0.75); C347(0.94); C665(0.95)  LDD1697  [17]
 LDCM0495  E2913 HEK-293T C633(0.92); C504(0.71); C347(1.19); C665(1.09)  LDD1698  [17]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C347(2.61); C633(1.38)  LDD1702  [4]
 LDCM0625  F8 Ramos C633(1.16); C504(1.75)  LDD2187  [18]
 LDCM0572  Fragment10 Ramos C633(0.74); C504(1.50)  LDD2189  [18]
 LDCM0573  Fragment11 Ramos C633(0.78); C504(14.24)  LDD2190  [18]
 LDCM0574  Fragment12 Ramos C633(0.64); C504(0.64)  LDD2191  [18]
 LDCM0575  Fragment13 Ramos C633(0.77); C504(0.78)  LDD2192  [18]
 LDCM0576  Fragment14 Ramos C633(0.63); C504(0.73)  LDD2193  [18]
 LDCM0579  Fragment20 Ramos C633(0.52); C504(0.76)  LDD2194  [18]
 LDCM0580  Fragment21 Ramos C633(0.92); C504(0.73)  LDD2195  [18]
 LDCM0582  Fragment23 Ramos C633(0.73); C504(1.05)  LDD2196  [18]
 LDCM0578  Fragment27 Ramos C633(0.88); C504(0.90)  LDD2197  [18]
 LDCM0586  Fragment28 Ramos C633(0.70); C504(1.27)  LDD2198  [18]
 LDCM0588  Fragment30 Ramos C633(1.64); C504(1.29)  LDD2199  [18]
 LDCM0589  Fragment31 Ramos C633(1.35); C504(0.96)  LDD2200  [18]
 LDCM0590  Fragment32 Ramos C633(0.78); C504(1.75)  LDD2201  [18]
 LDCM0468  Fragment33 HEK-293T C633(1.03); C504(0.98); C347(1.08); C665(1.02)  LDD1671  [17]
 LDCM0596  Fragment38 Ramos C633(1.13); C504(1.01)  LDD2203  [18]
 LDCM0566  Fragment4 Ramos C633(0.76); C504(1.14)  LDD2184  [18]
 LDCM0427  Fragment51 HEK-293T C633(1.33); C504(1.09); C347(0.96); C327(1.06)  LDD1631  [17]
 LDCM0610  Fragment52 Ramos C633(1.04); C504(0.88)  LDD2204  [18]
 LDCM0614  Fragment56 Ramos C633(2.01); C504(2.09)  LDD2205  [18]
 LDCM0569  Fragment7 Ramos C633(0.43); C504(0.78)  LDD2186  [18]
 LDCM0571  Fragment9 Ramos C633(0.62); C504(0.94)  LDD2188  [18]
 LDCM0022  KB02 HEK-293T C633(1.06); C504(0.98); C665(0.97); C327(1.10)  LDD1492  [17]
 LDCM0023  KB03 HEK-293T C633(0.99); C504(0.93); C665(0.96); C327(1.25)  LDD1497  [17]
 LDCM0024  KB05 G361 C693(4.06)  LDD3311  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C347(0.83); C633(0.87)  LDD2099  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C633(0.98)  LDD2109  [4]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C633(1.26)  LDD2118  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C347(0.77)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C347(0.96)  LDD2127  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C347(1.05)  LDD2129  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C347(1.33)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C347(1.03)  LDD2137  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C347(1.28)  LDD2144  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CCR4-NOT transcription complex subunit 11 (CNOT11) CNOT11 family Q9UKZ1
Trinucleotide repeat-containing gene 6C protein (TNRC6C) GW182 family Q9HCJ0

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578