Details of the Target

General Information of Target

Target ID LDTP12081
Target Name WD repeat-containing protein 54 (WDR54)
Gene Name WDR54
Gene ID 84058
Synonyms
WD repeat-containing protein 54
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKLSLTKVVNGCRLGKIKNLGKTGDHTMDIPGCLLYTKTGSAPHLTHHTLHNIHGVPAMA
QLTLSSLAEHHEVLTEYKEGVGKFIGMPESLLYCSLHDPVSPCPAGYVTNKSVSVWSVAG
RVEMTVSKFMAIQKALQPDWFQCLSDGEVSCKEATSIKRVRKSVDRSLLFLDNCLRLQEE
SEVLQKSVIIGVIEGGDVMEERLRSARETAKRPVGGFLLDGFQGNPTTLEARLRLLSSVT
AELPEDKPRLISGVSRPDEVLECIERGVDLFESFFPYQVTERGCALTFSFDYQPNPEETL
LQQNGTQEEIKCMDQIKKIETTGCNQEITSFEINLKEKKYQEDFNPLVRGCSCYCCKNHT
RAYIHHLLVTNELLAGVLLMMHNFEHYFGFFHYIREALKSDKLAQLKELIHRQAS
Target Bioclass
Other
Subcellular location
Vesicle
Function
When cross-linked to form dimers and trimers, it has a regulatory effect on ERK signaling pathway activity in response to EGF stimulation. Colocalizes with the EGF receptor in WDR54-specific vesicle where it sustains the internalization and controls the degradation of the EGF receptor after EGF stimulation.
Uniprot ID
Q9H977
Ensemble ID
ENST00000348227.4
HGNC ID
HGNC:25770

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.A128V DBIA    Probe Info 
HCT15 SNV: p.R3S .
HT3 SNV: p.S190Ter DBIA    Probe Info 
JURKAT SNV: p.C256Y .
NCIH2291 SNV: p.T137K .
RL952 SNV: p.G307C DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HHS-475
 Probe Info  		Y33(0.33)  LDD0264  [1]
HHS-465
 Probe Info  		Y33(7.61)  LDD2237  [2]
DBIA
 Probe Info  		C295(1.18); C299(1.18); C306(1.18)  LDD0078  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		C256(0.00); C18(0.00); C311(0.00)  LDD0038  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		C256(0.00); C78(0.00); C18(0.00)  LDD0037  [4]
WYneN
 Probe Info  		N.A.  LDD0021  [5]
IPM
 Probe Info  		N.A.  LDD2156  [6]
Acrolein
 Probe Info  		N.A.  LDD0217  [7]
NAIA_5
 Probe Info  		C256(0.00); C311(0.00)  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C256(0.89)  LDD1507  [9]
 LDCM0215  AC10 HEK-293T C295(1.02)  LDD0813  [3]
 LDCM0216  AC100 HEK-293T C295(1.04)  LDD0814  [3]
 LDCM0217  AC101 HEK-293T C295(1.01)  LDD0815  [3]
 LDCM0218  AC102 HEK-293T C295(1.10)  LDD0816  [3]
 LDCM0219  AC103 HEK-293T C295(1.05)  LDD0817  [3]
 LDCM0220  AC104 HEK-293T C295(0.95)  LDD0818  [3]
 LDCM0221  AC105 HEK-293T C295(1.06)  LDD0819  [3]
 LDCM0222  AC106 HEK-293T C295(1.08)  LDD0820  [3]
 LDCM0223  AC107 HEK-293T C295(1.04)  LDD0821  [3]
 LDCM0224  AC108 HEK-293T C295(1.04)  LDD0822  [3]
 LDCM0225  AC109 HEK-293T C295(1.04)  LDD0823  [3]
 LDCM0226  AC11 HEK-293T C295(1.04)  LDD0824  [3]
 LDCM0227  AC110 HEK-293T C295(1.04)  LDD0825  [3]
 LDCM0228  AC111 HEK-293T C295(1.20)  LDD0826  [3]
 LDCM0229  AC112 HEK-293T C295(1.17)  LDD0827  [3]
 LDCM0230  AC113 HEK-293T C295(0.96)  LDD0828  [3]
 LDCM0231  AC114 HEK-293T C295(0.99)  LDD0829  [3]
 LDCM0232  AC115 HEK-293T C295(0.92)  LDD0830  [3]
 LDCM0233  AC116 HEK-293T C295(0.90)  LDD0831  [3]
 LDCM0234  AC117 HEK-293T C295(0.96)  LDD0832  [3]
 LDCM0235  AC118 HEK-293T C295(0.98)  LDD0833  [3]
 LDCM0236  AC119 HEK-293T C295(0.94)  LDD0834  [3]
 LDCM0237  AC12 HEK-293T C295(1.08)  LDD0835  [3]
 LDCM0238  AC120 HEK-293T C295(0.87)  LDD0836  [3]
 LDCM0239  AC121 HEK-293T C295(0.90)  LDD0837  [3]
 LDCM0240  AC122 HEK-293T C295(0.96)  LDD0838  [3]
 LDCM0241  AC123 HEK-293T C295(1.02)  LDD0839  [3]
 LDCM0242  AC124 HEK-293T C295(0.89)  LDD0840  [3]
 LDCM0243  AC125 HEK-293T C295(1.00)  LDD0841  [3]
 LDCM0244  AC126 HEK-293T C295(0.99)  LDD0842  [3]
 LDCM0245  AC127 HEK-293T C295(1.08)  LDD0843  [3]
 LDCM0246  AC128 HEK-293T C295(1.19)  LDD0844  [3]
 LDCM0247  AC129 HEK-293T C295(1.10)  LDD0845  [3]
 LDCM0249  AC130 HEK-293T C295(1.16)  LDD0847  [3]
 LDCM0250  AC131 HEK-293T C295(1.15)  LDD0848  [3]
 LDCM0251  AC132 HEK-293T C295(1.19)  LDD0849  [3]
 LDCM0252  AC133 HEK-293T C295(1.16)  LDD0850  [3]
 LDCM0253  AC134 HEK-293T C295(1.25)  LDD0851  [3]
 LDCM0254  AC135 HEK-293T C295(1.21)  LDD0852  [3]
 LDCM0255  AC136 HEK-293T C295(1.18)  LDD0853  [3]
 LDCM0256  AC137 HEK-293T C295(1.24)  LDD0854  [3]
 LDCM0257  AC138 HEK-293T C295(1.35)  LDD0855  [3]
 LDCM0258  AC139 HEK-293T C295(1.15)  LDD0856  [3]
 LDCM0259  AC14 HEK-293T C295(0.93)  LDD0857  [3]
 LDCM0260  AC140 HEK-293T C295(1.21)  LDD0858  [3]
 LDCM0261  AC141 HEK-293T C295(1.23)  LDD0859  [3]
 LDCM0262  AC142 HEK-293T C295(1.16)  LDD0860  [3]
 LDCM0263  AC143 HEK-293T C295(0.98)  LDD0861  [3]
 LDCM0264  AC144 HEK-293T C295(0.95)  LDD0862  [3]
 LDCM0265  AC145 HEK-293T C295(0.97)  LDD0863  [3]
 LDCM0266  AC146 HEK-293T C295(0.94)  LDD0864  [3]
 LDCM0267  AC147 HEK-293T C295(0.97)  LDD0865  [3]
 LDCM0268  AC148 HEK-293T C295(1.04)  LDD0866  [3]
 LDCM0269  AC149 HEK-293T C295(1.00)  LDD0867  [3]
 LDCM0270  AC15 HEK-293T C295(0.97)  LDD0868  [3]
 LDCM0271  AC150 HEK-293T C295(0.94)  LDD0869  [3]
 LDCM0272  AC151 HEK-293T C295(1.05)  LDD0870  [3]
 LDCM0273  AC152 HEK-293T C295(1.09)  LDD0871  [3]
 LDCM0274  AC153 HEK-293T C295(1.03)  LDD0872  [3]
 LDCM0621  AC154 HEK-293T C295(0.87)  LDD2162  [3]
 LDCM0622  AC155 HEK-293T C295(0.98)  LDD2163  [3]
 LDCM0623  AC156 HEK-293T C295(0.93)  LDD2164  [3]
 LDCM0624  AC157 HEK-293T C295(0.99)  LDD2165  [3]
 LDCM0276  AC17 HEK-293T C295(0.76)  LDD0874  [3]
 LDCM0277  AC18 HEK-293T C295(0.74)  LDD0875  [3]
 LDCM0278  AC19 HEK-293T C295(0.76)  LDD0876  [3]
 LDCM0279  AC2 HEK-293T C256(0.89)  LDD1518  [9]
 LDCM0280  AC20 HEK-293T C295(0.85)  LDD0878  [3]
 LDCM0281  AC21 HEK-293T C295(0.81)  LDD0879  [3]
 LDCM0282  AC22 HEK-293T C295(0.74)  LDD0880  [3]
 LDCM0283  AC23 HEK-293T C295(0.67)  LDD0881  [3]
 LDCM0284  AC24 HEK-293T C295(0.85)  LDD0882  [3]
 LDCM0285  AC25 HEK-293T C256(0.88)  LDD1524  [9]
 LDCM0286  AC26 HEK-293T C256(0.88)  LDD1525  [9]
 LDCM0287  AC27 HEK-293T C256(1.36); C295(1.20)  LDD1526  [9]
 LDCM0289  AC29 HEK-293T C256(1.32); C299(1.21)  LDD1528  [9]
 LDCM0290  AC3 HEK-293T C256(1.06); C295(0.93)  LDD1529  [9]
 LDCM0291  AC30 HEK-293T C256(0.96); C299(1.17)  LDD1530  [9]
 LDCM0292  AC31 HEK-293T C256(1.35)  LDD1531  [9]
 LDCM0294  AC33 HEK-293T C256(1.01)  LDD1533  [9]
 LDCM0295  AC34 HEK-293T C256(0.94)  LDD1534  [9]
 LDCM0296  AC35 HEK-293T C295(1.04)  LDD0894  [3]
 LDCM0297  AC36 HEK-293T C295(0.86)  LDD0895  [3]
 LDCM0298  AC37 HEK-293T C295(0.84)  LDD0896  [3]
 LDCM0299  AC38 HEK-293T C295(0.75)  LDD0897  [3]
 LDCM0300  AC39 HEK-293T C295(0.87)  LDD0898  [3]
 LDCM0302  AC40 HEK-293T C295(0.87)  LDD0900  [3]
 LDCM0303  AC41 HEK-293T C295(0.94)  LDD0901  [3]
 LDCM0304  AC42 HEK-293T C295(0.84)  LDD0902  [3]
 LDCM0305  AC43 HEK-293T C295(1.09)  LDD0903  [3]
 LDCM0306  AC44 HEK-293T C295(0.82)  LDD0904  [3]
 LDCM0307  AC45 HEK-293T C295(0.81)  LDD0905  [3]
 LDCM0308  AC46 HEK-293T C295(1.04)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C295(0.95)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C295(0.93)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C295(0.88)  LDD0909  [3]
 LDCM0312  AC5 HEK-293T C256(0.71); C299(0.98)  LDD1551  [9]
 LDCM0313  AC50 HEK-293T C295(0.88)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C295(0.78)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C295(0.87)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C295(0.86)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C295(0.76)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C295(0.94)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C295(0.89)  LDD0917  [3]
 LDCM0320  AC57 HEK-293T C295(1.02)  LDD0918  [3]
 LDCM0321  AC58 HEK-293T C295(0.97)  LDD0919  [3]
 LDCM0322  AC59 HEK-293T C295(0.96)  LDD0920  [3]
 LDCM0323  AC6 HEK-293T C295(1.11)  LDD0921  [3]
 LDCM0324  AC60 HEK-293T C295(0.84)  LDD0922  [3]
 LDCM0325  AC61 HEK-293T C295(0.89)  LDD0923  [3]
 LDCM0326  AC62 HEK-293T C295(0.91)  LDD0924  [3]
 LDCM0327  AC63 HEK-293T C295(0.90)  LDD0925  [3]
 LDCM0328  AC64 HEK-293T C295(0.82)  LDD0926  [3]
 LDCM0329  AC65 HEK-293T C295(0.82)  LDD0927  [3]
 LDCM0330  AC66 HEK-293T C295(0.89)  LDD0928  [3]
 LDCM0331  AC67 HEK-293T C295(0.83)  LDD0929  [3]
 LDCM0334  AC7 HEK-293T C295(0.98)  LDD0932  [3]
 LDCM0345  AC8 HEK-293T C295(0.85)  LDD0943  [3]
 LDCM0349  AC83 HEK-293T C295(1.01)  LDD0947  [3]
 LDCM0350  AC84 HEK-293T C295(0.93)  LDD0948  [3]
 LDCM0351  AC85 HEK-293T C295(0.96)  LDD0949  [3]
 LDCM0352  AC86 HEK-293T C295(0.90)  LDD0950  [3]
 LDCM0353  AC87 HEK-293T C295(0.90)  LDD0951  [3]
 LDCM0354  AC88 HEK-293T C295(0.90)  LDD0952  [3]
 LDCM0355  AC89 HEK-293T C295(0.83)  LDD0953  [3]
 LDCM0357  AC90 HEK-293T C295(0.86)  LDD0955  [3]
 LDCM0358  AC91 HEK-293T C295(0.90)  LDD0956  [3]
 LDCM0359  AC92 HEK-293T C295(0.92)  LDD0957  [3]
 LDCM0360  AC93 HEK-293T C295(1.01)  LDD0958  [3]
 LDCM0361  AC94 HEK-293T C295(0.88)  LDD0959  [3]
 LDCM0362  AC95 HEK-293T C295(0.85)  LDD0960  [3]
 LDCM0363  AC96 HEK-293T C295(0.93)  LDD0961  [3]
 LDCM0364  AC97 HEK-293T C295(0.98)  LDD0962  [3]
 LDCM0365  AC98 HEK-293T C295(1.10)  LDD0963  [3]
 LDCM0366  AC99 HEK-293T C295(1.06)  LDD0964  [3]
 LDCM0248  AKOS034007472 HEK-293T C295(1.06)  LDD0846  [3]
 LDCM0356  AKOS034007680 HEK-293T C295(0.90)  LDD0954  [3]
 LDCM0275  AKOS034007705 HEK-293T C295(0.87)  LDD0873  [3]
 LDCM0020  ARS-1620 HCC44 C295(1.18); C299(1.18); C306(1.18)  LDD0078  [3]
 LDCM0367  CL1 HEK-293T C295(0.85)  LDD0965  [3]
 LDCM0368  CL10 HEK-293T C295(0.88)  LDD0966  [3]
 LDCM0369  CL100 HEK-293T C256(0.94)  LDD1573  [9]
 LDCM0370  CL101 HEK-293T C295(0.84)  LDD0968  [3]
 LDCM0371  CL102 HEK-293T C295(0.80)  LDD0969  [3]
 LDCM0372  CL103 HEK-293T C295(0.88)  LDD0970  [3]
 LDCM0373  CL104 HEK-293T C295(0.98)  LDD0971  [3]
 LDCM0374  CL105 HEK-293T C295(0.87)  LDD0972  [3]
 LDCM0375  CL106 HEK-293T C295(0.89)  LDD0973  [3]
 LDCM0376  CL107 HEK-293T C295(0.82)  LDD0974  [3]
 LDCM0377  CL108 HEK-293T C295(0.77)  LDD0975  [3]
 LDCM0378  CL109 HEK-293T C295(0.81)  LDD0976  [3]
 LDCM0379  CL11 HEK-293T C295(0.94)  LDD0977  [3]
 LDCM0380  CL110 HEK-293T C295(0.72)  LDD0978  [3]
 LDCM0381  CL111 HEK-293T C295(0.70)  LDD0979  [3]
 LDCM0382  CL112 HEK-293T C256(0.83)  LDD1586  [9]
 LDCM0383  CL113 HEK-293T C256(0.90)  LDD1587  [9]
 LDCM0384  CL114 HEK-293T C299(0.87)  LDD1588  [9]
 LDCM0386  CL116 HEK-293T C256(0.90)  LDD1590  [9]
 LDCM0387  CL117 HEK-293T C295(0.73)  LDD0985  [3]
 LDCM0388  CL118 HEK-293T C295(0.82)  LDD0986  [3]
 LDCM0389  CL119 HEK-293T C295(0.86)  LDD0987  [3]
 LDCM0390  CL12 HEK-293T C295(0.86)  LDD0988  [3]
 LDCM0391  CL120 HEK-293T C295(0.95)  LDD0989  [3]
 LDCM0392  CL121 HEK-293T C295(0.82)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C295(0.93)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C295(0.81)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C295(0.89)  LDD0993  [3]
 LDCM0396  CL125 HEK-293T C295(0.98)  LDD0994  [3]
 LDCM0397  CL126 HEK-293T C295(0.90)  LDD0995  [3]
 LDCM0398  CL127 HEK-293T C295(1.15)  LDD0996  [3]
 LDCM0399  CL128 HEK-293T C295(0.99)  LDD0997  [3]
 LDCM0400  CL13 HEK-293T C295(0.91)  LDD0998  [3]
 LDCM0401  CL14 HEK-293T C295(0.89)  LDD0999  [3]
 LDCM0402  CL15 HEK-293T C295(0.80)  LDD1000  [3]
 LDCM0403  CL16 HEK-293T C295(0.96)  LDD1001  [3]
 LDCM0404  CL17 HEK-293T C295(0.83)  LDD1002  [3]
 LDCM0405  CL18 HEK-293T C295(0.92)  LDD1003  [3]
 LDCM0406  CL19 HEK-293T C295(0.93)  LDD1004  [3]
 LDCM0407  CL2 HEK-293T C295(0.85)  LDD1005  [3]
 LDCM0408  CL20 HEK-293T C295(0.85)  LDD1006  [3]
 LDCM0409  CL21 HEK-293T C295(0.92)  LDD1007  [3]
 LDCM0410  CL22 HEK-293T C295(0.82)  LDD1008  [3]
 LDCM0411  CL23 HEK-293T C295(0.81)  LDD1009  [3]
 LDCM0412  CL24 HEK-293T C295(0.89)  LDD1010  [3]
 LDCM0413  CL25 HEK-293T C295(0.85)  LDD1011  [3]
 LDCM0414  CL26 HEK-293T C295(0.94)  LDD1012  [3]
 LDCM0415  CL27 HEK-293T C295(0.92)  LDD1013  [3]
 LDCM0416  CL28 HEK-293T C295(0.92)  LDD1014  [3]
 LDCM0417  CL29 HEK-293T C295(0.88)  LDD1015  [3]
 LDCM0418  CL3 HEK-293T C295(0.84)  LDD1016  [3]
 LDCM0419  CL30 HEK-293T C295(0.89)  LDD1017  [3]
 LDCM0420  CL31 HEK-293T C256(1.20); C295(1.05)  LDD1624  [9]
 LDCM0422  CL33 HEK-293T C256(1.23); C299(1.07)  LDD1626  [9]
 LDCM0423  CL34 HEK-293T C256(1.02); C299(0.93)  LDD1627  [9]
 LDCM0424  CL35 HEK-293T C256(1.32)  LDD1628  [9]
 LDCM0426  CL37 HEK-293T C256(0.86)  LDD1630  [9]
 LDCM0429  CL4 HEK-293T C295(0.81)  LDD1027  [3]
 LDCM0430  CL40 HEK-293T C256(0.91)  LDD1634  [9]
 LDCM0431  CL41 HEK-293T C256(0.81)  LDD1635  [9]
 LDCM0432  CL42 HEK-293T C256(0.96)  LDD1636  [9]
 LDCM0433  CL43 HEK-293T C256(1.41); C295(1.13)  LDD1637  [9]
 LDCM0435  CL45 HEK-293T C256(0.94); C299(1.07)  LDD1639  [9]
 LDCM0436  CL46 HEK-293T C295(0.90)  LDD1034  [3]
 LDCM0437  CL47 HEK-293T C295(0.94)  LDD1035  [3]
 LDCM0438  CL48 HEK-293T C295(0.96)  LDD1036  [3]
 LDCM0439  CL49 HEK-293T C295(0.96)  LDD1037  [3]
 LDCM0440  CL5 HEK-293T C295(0.89)  LDD1038  [3]
 LDCM0441  CL50 HEK-293T C295(1.07)  LDD1039  [3]
 LDCM0442  CL51 HEK-293T C295(1.05)  LDD1040  [3]
 LDCM0443  CL52 HEK-293T C295(1.11)  LDD1041  [3]
 LDCM0444  CL53 HEK-293T C295(1.12)  LDD1042  [3]
 LDCM0445  CL54 HEK-293T C295(1.02)  LDD1043  [3]
 LDCM0446  CL55 HEK-293T C295(1.01)  LDD1044  [3]
 LDCM0447  CL56 HEK-293T C295(0.87)  LDD1045  [3]
 LDCM0448  CL57 HEK-293T C295(0.98)  LDD1046  [3]
 LDCM0449  CL58 HEK-293T C295(1.03)  LDD1047  [3]
 LDCM0450  CL59 HEK-293T C295(0.96)  LDD1048  [3]
 LDCM0451  CL6 HEK-293T C295(0.86)  LDD1049  [3]
 LDCM0452  CL60 HEK-293T C295(1.07)  LDD1050  [3]
 LDCM0453  CL61 HEK-293T C295(0.95)  LDD1051  [3]
 LDCM0454  CL62 HEK-293T C295(0.86)  LDD1052  [3]
 LDCM0455  CL63 HEK-293T C295(0.91)  LDD1053  [3]
 LDCM0456  CL64 HEK-293T C295(0.99)  LDD1054  [3]
 LDCM0457  CL65 HEK-293T C295(0.96)  LDD1055  [3]
 LDCM0458  CL66 HEK-293T C295(0.93)  LDD1056  [3]
 LDCM0459  CL67 HEK-293T C295(0.91)  LDD1057  [3]
 LDCM0460  CL68 HEK-293T C295(0.94)  LDD1058  [3]
 LDCM0461  CL69 HEK-293T C295(0.91)  LDD1059  [3]
 LDCM0462  CL7 HEK-293T C295(0.82)  LDD1060  [3]
 LDCM0463  CL70 HEK-293T C295(0.95)  LDD1061  [3]
 LDCM0464  CL71 HEK-293T C295(0.93)  LDD1062  [3]
 LDCM0465  CL72 HEK-293T C295(0.94)  LDD1063  [3]
 LDCM0466  CL73 HEK-293T C295(0.84)  LDD1064  [3]
 LDCM0467  CL74 HEK-293T C295(0.89)  LDD1065  [3]
 LDCM0469  CL76 HEK-293T C256(0.88)  LDD1672  [9]
 LDCM0470  CL77 HEK-293T C256(0.87)  LDD1673  [9]
 LDCM0471  CL78 HEK-293T C256(0.98)  LDD1674  [9]
 LDCM0472  CL79 HEK-293T C256(1.46); C295(1.06)  LDD1675  [9]
 LDCM0475  CL81 HEK-293T C256(0.69); C299(1.05)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C256(1.11); C299(0.82)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C256(1.05)  LDD1680  [9]
 LDCM0479  CL85 HEK-293T C256(0.85)  LDD1682  [9]
 LDCM0480  CL86 HEK-293T C299(0.94)  LDD1683  [9]
 LDCM0482  CL88 HEK-293T C256(0.93)  LDD1685  [9]
 LDCM0483  CL89 HEK-293T C256(0.86)  LDD1686  [9]
 LDCM0484  CL9 HEK-293T C256(1.01); C299(1.27)  LDD1687  [9]
 LDCM0485  CL90 HEK-293T C256(0.88)  LDD1688  [9]
 LDCM0486  CL91 HEK-293T C256(1.19); C295(1.19)  LDD1689  [9]
 LDCM0488  CL93 HEK-293T C256(1.11); C299(1.12)  LDD1691  [9]
 LDCM0489  CL94 HEK-293T C256(1.06); C299(0.80)  LDD1692  [9]
 LDCM0490  CL95 HEK-293T C256(0.79)  LDD1693  [9]
 LDCM0492  CL97 HEK-293T C256(0.95)  LDD1695  [9]
 LDCM0493  CL98 HEK-293T C299(1.20)  LDD1696  [9]
 LDCM0468  Fragment33 HEK-293T C295(0.78)  LDD1066  [3]
 LDCM0427  Fragment51 HEK-293T C299(1.14)  LDD1631  [9]
 LDCM0116  HHS-0101 DM93 Y33(0.33)  LDD0264  [1]
 LDCM0117  HHS-0201 DM93 Y33(0.91)  LDD0265  [1]
 LDCM0119  HHS-0401 DM93 Y33(1.86)  LDD0267  [1]
 LDCM0120  HHS-0701 DM93 Y33(0.85)  LDD0268  [1]
 LDCM0022  KB02 22RV1 C271(1.44)  LDD2243  [10]
 LDCM0023  KB03 Jurkat C256(6.74)  LDD0209  [11]
 LDCM0024  KB05 WM115 C33(0.96)  LDD3327  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Uridine diphosphate glucose pyrophosphatase NUDT22 (NUDT22) Nudix hydrolase family Q9BRQ3

References

1 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
2 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
11 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.