Details of the Target

General Information of Target

Target ID LDTP11598
Target Name Semaphorin-4C (SEMA4C)
Gene Name SEMA4C
Gene ID 54910
Synonyms
KIAA1739; SEMAI; Semaphorin-4C
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKVSTLRESSAMASPLPREMEEELVPTGSEPGDTRAKPPVKPKPRALPAKPALPAKPSLL
VPVGPRPPRGPLAELPSARKMNMLAGPQPYGGSKRPLPFAPRPAVEASTGGEATQETGKE
EAGKEEPPPLTPPARCAAPGGVRKAPAPFRPASERFAATTVEEILAKMEQPRKEVLASPD
RLWGSRLTFNHDGSSRYGPRTYGTTTAPRDEDGSTLFRGWSQEGPVKSPAECREEHSKTP
EERSLPSDLAFNGDLAKAASSELPADISKPWIPSSPAPSSENGGPASPGLPAEASGSGPG
SPHLHPPDKSSPCHSQLLEAQTPEASQASPCPAVTPSAPSAALPDEGSRHTPSPGLPAEG
APEAPRPSSPPPEVLEPHSLDQPPATSPRPLIEVGELLDLTRTFPSGGEEEAKGDAHLRP
TSLVQRRFSEGVLQSPSQDQEKLGGSLAALPQGQGSQLALDRPFGAESNWSLSQSFEWTF
PTRPSGLGVWRLDSPPPSPITEASEAAEAAEAGNLAVSSREEGVSQQGQGAGSAPSGSGS
SWVQGDDPSMSLTQKGDGESQPQFPAVPLEPLPTTEGTPGLPLQQAEERYESQEPLAGQE
SPLPLATREAALPILEPVLGQEQPAAPDQPCVLFADAPEPGQALPVEEEAVTLARAETTQ
ARTEAQDLCRASPEPPGPESSSRWLDDLLASPPPSGGGARRGAGAELKDTQSPSTCSEGL
LGWSQKDLQSEFGITGDPQPSSFSPSSWCQGASQDYGLGGASPRGDPGLGERDWTSKYGQ
GAGEGSTREWASRCGIGQEEMEASSSQDQSKVSAPGVLTAQDRVVGKPAQLGTQRSQEAD
VQDWEFRKRDSQGTYSSRDAELQDQEFGKRDSLGTYSSRDVSLGDWEFGKRDSLGAYASQ
DANEQGQDLGKRDHHGRYSSQDADEQDWEFQKRDVSLGTYGSRAAEPQEQEFGKSAWIRD
YSSGGSSRTLDAQDRSFGTRPLSSGFSPEEAQQQDEEFEKKIPSVEDSLGEGSRDAGRPG
ERGSGGLFSPSTAHVPDGALGQRDQSSWQNSDASQEVGGHQERQQAGAQGPGSADLEDGE
MGKRGWVGEFSLSVGPQREAAFSPGQQDWSRDFCIEASERSYQFGIIGNDRVSGAGFSPS
SKMEGGHFVPPGKTTAGSVDWTDQLGLRNLEVSSCVGSGGSSEARESAVGQMGWSGGLSL
RDMNLTGCLESGGSEEPGGIGVGEKDWTSDVNVKSKDLAEVGEGGGHSQARESGVGQTDW
SGVEAGEFLKSRERGVGQADWTPDLGLRNMAPGAVCSPGESKELGVGQMDWGNNLGLRDL
EVTCDPDSGGSQGLRGCGVGQMDWTQDLAPQNVELFGAPSEAREHGVGGVSQCPEPGLRH
NGSLSPGLEARDPLEARELGVGETSGPETQGEDYSSSSLEPHPADPGMETGEALSFGASP
GRCPARPPPSGSQGLLEEMLAASSSKAVARRESAASGLGGLLEEEGAGAGAAQEEVLEPG
RDSPPSWRPQPDGEASQTEDVDGTWGSSAARWSDQGPAQTSRRPSQGPPARSPSQDFSFI
EDTEILDSAMYRSRANLGRKRGHRAPVIRPGGTLGLSEAADSDAHLFQDSTEPRASRVPS
SDEEVVEEPQSRRTRMSLGTKGLKVNLFPGLSPSALKAKLRPRNRSAEEGELAESKSSQK
ESAVQRSKSCKVPGLGKPLTLPPKPEKSSGSEGSSPNWLQALKLKKKKV
Target Bioclass
Immunoglobulin
Family
Semaphorin family
Subcellular location
Postsynaptic density membrane
Function
Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration. Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade.
Uniprot ID
Q9C0C4
Ensemble ID
ENST00000305476.10
HGNC ID
HGNC:10731

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		8.04  LDD0318  [1]
IPM
 Probe Info  		N.A.  LDD0241  [2]
Probe 1
 Probe Info  		Y605(9.64)  LDD3495  [3]
BTD
 Probe Info  		C370(0.81)  LDD2150  [4]
AHL-Pu-1
 Probe Info  		C723(2.96)  LDD0171  [5]
DBIA
 Probe Info  		C248(0.96)  LDD0078  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [7]
NAIA_5
 Probe Info  		C248(0.00); C627(0.00); C99(0.00); C261(0.00)  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C723(2.96)  LDD0171  [5]
 LDCM0214  AC1 HEK-293T C248(1.27)  LDD1507  [9]
 LDCM0215  AC10 PaTu 8988t C248(1.55)  LDD1094  [6]
 LDCM0226  AC11 PaTu 8988t C248(1.86)  LDD1105  [6]
 LDCM0230  AC113 PaTu 8988t C248(0.95)  LDD1109  [6]
 LDCM0231  AC114 PaTu 8988t C248(1.44)  LDD1110  [6]
 LDCM0232  AC115 PaTu 8988t C248(1.63)  LDD1111  [6]
 LDCM0233  AC116 PaTu 8988t C248(0.75)  LDD1112  [6]
 LDCM0234  AC117 PaTu 8988t C248(1.33)  LDD1113  [6]
 LDCM0235  AC118 PaTu 8988t C248(1.55)  LDD1114  [6]
 LDCM0236  AC119 PaTu 8988t C248(1.14)  LDD1115  [6]
 LDCM0237  AC12 PaTu 8988t C248(1.77)  LDD1116  [6]
 LDCM0238  AC120 PaTu 8988t C248(1.51)  LDD1117  [6]
 LDCM0239  AC121 PaTu 8988t C248(0.96)  LDD1118  [6]
 LDCM0240  AC122 PaTu 8988t C248(1.07)  LDD1119  [6]
 LDCM0241  AC123 PaTu 8988t C248(1.01)  LDD1120  [6]
 LDCM0242  AC124 PaTu 8988t C248(1.15)  LDD1121  [6]
 LDCM0243  AC125 PaTu 8988t C248(1.70)  LDD1122  [6]
 LDCM0244  AC126 PaTu 8988t C248(1.56)  LDD1123  [6]
 LDCM0245  AC127 PaTu 8988t C248(1.02)  LDD1124  [6]
 LDCM0259  AC14 PaTu 8988t C248(1.87)  LDD1138  [6]
 LDCM0263  AC143 PaTu 8988t C248(1.40)  LDD1142  [6]
 LDCM0264  AC144 PaTu 8988t C248(1.42)  LDD1143  [6]
 LDCM0265  AC145 PaTu 8988t C248(1.77)  LDD1144  [6]
 LDCM0266  AC146 PaTu 8988t C248(1.60)  LDD1145  [6]
 LDCM0267  AC147 PaTu 8988t C248(1.50)  LDD1146  [6]
 LDCM0268  AC148 PaTu 8988t C248(1.45)  LDD1147  [6]
 LDCM0269  AC149 PaTu 8988t C248(1.61)  LDD1148  [6]
 LDCM0270  AC15 PaTu 8988t C248(2.44)  LDD1149  [6]
 LDCM0271  AC150 PaTu 8988t C248(1.47)  LDD1150  [6]
 LDCM0272  AC151 PaTu 8988t C248(1.59)  LDD1151  [6]
 LDCM0273  AC152 PaTu 8988t C248(1.73)  LDD1152  [6]
 LDCM0274  AC153 PaTu 8988t C248(1.62)  LDD1153  [6]
 LDCM0621  AC154 PaTu 8988t C248(1.34)  LDD2166  [6]
 LDCM0622  AC155 PaTu 8988t C248(1.74)  LDD2167  [6]
 LDCM0623  AC156 PaTu 8988t C248(1.23)  LDD2168  [6]
 LDCM0624  AC157 PaTu 8988t C248(1.28)  LDD2169  [6]
 LDCM0276  AC17 PaTu 8988t C248(0.74)  LDD1155  [6]
 LDCM0277  AC18 PaTu 8988t C248(0.91)  LDD1156  [6]
 LDCM0278  AC19 PaTu 8988t C248(1.05)  LDD1157  [6]
 LDCM0279  AC2 HEK-293T C159(1.17); C723(0.92)  LDD1518  [9]
 LDCM0280  AC20 PaTu 8988t C248(1.03)  LDD1159  [6]
 LDCM0281  AC21 PaTu 8988t C248(0.88)  LDD1160  [6]
 LDCM0282  AC22 PaTu 8988t C248(0.90)  LDD1161  [6]
 LDCM0283  AC23 PaTu 8988t C248(1.16)  LDD1162  [6]
 LDCM0284  AC24 PaTu 8988t C248(1.14)  LDD1163  [6]
 LDCM0285  AC25 HEK-293T C248(1.27)  LDD1524  [9]
 LDCM0286  AC26 HEK-293T C159(1.04); C723(1.09)  LDD1525  [9]
 LDCM0287  AC27 HEK-293T C723(1.12); C248(1.15)  LDD1526  [9]
 LDCM0289  AC29 HEK-293T C723(1.00)  LDD1528  [9]
 LDCM0290  AC3 HEK-293T C723(1.12); C248(1.49)  LDD1529  [9]
 LDCM0291  AC30 HEK-293T C159(1.04); C723(1.09)  LDD1530  [9]
 LDCM0292  AC31 HEK-293T C723(0.88)  LDD1531  [9]
 LDCM0293  AC32 HEK-293T C159(1.02); C723(1.03)  LDD1532  [9]
 LDCM0294  AC33 HEK-293T C248(1.34)  LDD1533  [9]
 LDCM0295  AC34 HEK-293T C159(1.04); C723(1.06)  LDD1534  [9]
 LDCM0296  AC35 PaTu 8988t C248(1.25)  LDD1175  [6]
 LDCM0297  AC36 PaTu 8988t C248(0.80)  LDD1176  [6]
 LDCM0298  AC37 PaTu 8988t C248(0.80)  LDD1177  [6]
 LDCM0299  AC38 PaTu 8988t C248(0.94)  LDD1178  [6]
 LDCM0300  AC39 PaTu 8988t C248(0.92)  LDD1179  [6]
 LDCM0302  AC40 PaTu 8988t C248(0.84)  LDD1181  [6]
 LDCM0303  AC41 PaTu 8988t C248(0.83)  LDD1182  [6]
 LDCM0304  AC42 PaTu 8988t C248(0.87)  LDD1183  [6]
 LDCM0305  AC43 PaTu 8988t C248(1.11)  LDD1184  [6]
 LDCM0306  AC44 PaTu 8988t C248(0.76)  LDD1185  [6]
 LDCM0307  AC45 PaTu 8988t C248(0.91)  LDD1186  [6]
 LDCM0308  AC46 HEK-293T C159(1.07); C723(0.97)  LDD1547  [9]
 LDCM0309  AC47 HEK-293T C723(0.93)  LDD1548  [9]
 LDCM0310  AC48 HEK-293T C159(1.04); C723(1.05)  LDD1549  [9]
 LDCM0311  AC49 HEK-293T C248(1.08)  LDD1550  [9]
 LDCM0312  AC5 HEK-293T C723(1.06)  LDD1551  [9]
 LDCM0313  AC50 HEK-293T C159(1.04); C723(1.11)  LDD1552  [9]
 LDCM0314  AC51 HEK-293T C723(1.01); C248(1.07)  LDD1553  [9]
 LDCM0316  AC53 HEK-293T C723(1.09)  LDD1555  [9]
 LDCM0317  AC54 HEK-293T C159(1.03); C723(1.08)  LDD1556  [9]
 LDCM0318  AC55 HEK-293T C723(0.99)  LDD1557  [9]
 LDCM0319  AC56 HEK-293T C159(1.06); C723(0.96)  LDD1558  [9]
 LDCM0320  AC57 HEK-293T C248(1.28)  LDD1559  [9]
 LDCM0321  AC58 HEK-293T C159(1.23); C723(0.97)  LDD1560  [9]
 LDCM0322  AC59 HEK-293T C723(1.09); C248(1.19)  LDD1561  [9]
 LDCM0323  AC6 PaTu 8988t C248(1.52)  LDD1202  [6]
 LDCM0325  AC61 HEK-293T C723(0.99)  LDD1564  [9]
 LDCM0326  AC62 HEK-293T C159(1.01); C723(1.21)  LDD1565  [9]
 LDCM0327  AC63 HEK-293T C723(0.92)  LDD1566  [9]
 LDCM0328  AC64 HEK-293T C159(1.05); C723(0.97)  LDD1567  [9]
 LDCM0334  AC7 PaTu 8988t C248(1.06)  LDD1213  [6]
 LDCM0345  AC8 PaTu 8988t C248(1.31)  LDD1224  [6]
 LDCM0248  AKOS034007472 PaTu 8988t C248(2.03)  LDD1127  [6]
 LDCM0356  AKOS034007680 PaTu 8988t C248(2.51)  LDD1235  [6]
 LDCM0275  AKOS034007705 PaTu 8988t C248(1.54)  LDD1154  [6]
 LDCM0020  ARS-1620 HCC44 C248(0.96)  LDD0078  [6]
 LDCM0367  CL1 HEK-293T C159(1.08); C723(0.83)  LDD1571  [9]
 LDCM0368  CL10 HEK-293T C159(1.36); C723(1.33)  LDD1572  [9]
 LDCM0369  CL100 HEK-293T C159(1.32); C248(0.91)  LDD1573  [9]
 LDCM0370  CL101 PaTu 8988t C248(1.59)  LDD1249  [6]
 LDCM0371  CL102 PaTu 8988t C248(1.55)  LDD1250  [6]
 LDCM0372  CL103 PaTu 8988t C248(2.68)  LDD1251  [6]
 LDCM0373  CL104 PaTu 8988t C248(1.49)  LDD1252  [6]
 LDCM0374  CL105 PaTu 8988t C248(0.96)  LDD1253  [6]
 LDCM0375  CL106 PaTu 8988t C248(1.00)  LDD1254  [6]
 LDCM0376  CL107 PaTu 8988t C248(0.99)  LDD1255  [6]
 LDCM0377  CL108 PaTu 8988t C248(0.88)  LDD1256  [6]
 LDCM0378  CL109 PaTu 8988t C248(1.03)  LDD1257  [6]
 LDCM0379  CL11 HEK-293T C723(1.00)  LDD1583  [9]
 LDCM0380  CL110 PaTu 8988t C248(0.91)  LDD1259  [6]
 LDCM0381  CL111 PaTu 8988t C248(1.38)  LDD1260  [6]
 LDCM0382  CL112 HEK-293T C159(1.00); C248(1.26)  LDD1586  [9]
 LDCM0383  CL113 HEK-293T C159(1.00); C723(1.09)  LDD1587  [9]
 LDCM0384  CL114 HEK-293T C159(0.94)  LDD1588  [9]
 LDCM0386  CL116 HEK-293T C159(1.17); C248(0.89)  LDD1590  [9]
 LDCM0387  CL117 PaTu 8988t C248(0.93)  LDD1266  [6]
 LDCM0388  CL118 PaTu 8988t C248(0.77)  LDD1267  [6]
 LDCM0389  CL119 PaTu 8988t C248(0.95)  LDD1268  [6]
 LDCM0390  CL12 HEK-293T C159(1.14); C723(1.01)  LDD1594  [9]
 LDCM0391  CL120 PaTu 8988t C248(1.47)  LDD1270  [6]
 LDCM0392  CL121 HEK-293T C159(1.05); C723(1.14)  LDD1596  [9]
 LDCM0393  CL122 HEK-293T C159(0.94)  LDD1597  [9]
 LDCM0395  CL124 HEK-293T C159(1.02); C248(0.95)  LDD1599  [9]
 LDCM0396  CL125 HEK-293T C159(1.00); C723(1.11)  LDD1600  [9]
 LDCM0397  CL126 HEK-293T C159(1.04)  LDD1601  [9]
 LDCM0399  CL128 HEK-293T C159(1.04); C248(1.05)  LDD1603  [9]
 LDCM0400  CL13 HEK-293T C159(1.09); C723(1.31)  LDD1604  [9]
 LDCM0401  CL14 HEK-293T C159(1.03)  LDD1605  [9]
 LDCM0403  CL16 HEK-293T C159(1.01); C248(1.24)  LDD1607  [9]
 LDCM0404  CL17 HEK-293T C248(1.37)  LDD1608  [9]
 LDCM0405  CL18 HEK-293T C159(1.18); C723(1.14)  LDD1609  [9]
 LDCM0406  CL19 HEK-293T C723(1.16); C248(1.19)  LDD1610  [9]
 LDCM0407  CL2 HEK-293T C159(1.08)  LDD1611  [9]
 LDCM0409  CL21 HEK-293T C723(1.27)  LDD1613  [9]
 LDCM0410  CL22 HEK-293T C159(1.18); C723(1.18)  LDD1614  [9]
 LDCM0411  CL23 HEK-293T C723(1.00)  LDD1615  [9]
 LDCM0412  CL24 HEK-293T C159(1.08); C723(0.94)  LDD1616  [9]
 LDCM0413  CL25 HEK-293T C159(1.01); C723(1.17)  LDD1617  [9]
 LDCM0414  CL26 HEK-293T C159(0.93)  LDD1618  [9]
 LDCM0416  CL28 HEK-293T C159(1.14); C248(1.21)  LDD1620  [9]
 LDCM0417  CL29 HEK-293T C248(1.21)  LDD1621  [9]
 LDCM0419  CL30 HEK-293T C159(1.32); C723(1.07)  LDD1623  [9]
 LDCM0420  CL31 HEK-293T C723(1.05); C248(1.30)  LDD1624  [9]
 LDCM0422  CL33 HEK-293T C723(1.22)  LDD1626  [9]
 LDCM0423  CL34 HEK-293T C159(1.06); C723(0.98)  LDD1627  [9]
 LDCM0424  CL35 HEK-293T C723(1.12)  LDD1628  [9]
 LDCM0425  CL36 HEK-293T C159(1.19); C723(1.09)  LDD1629  [9]
 LDCM0426  CL37 HEK-293T C159(0.97); C723(1.18)  LDD1630  [9]
 LDCM0429  CL4 HEK-293T C159(1.08); C248(1.18)  LDD1633  [9]
 LDCM0430  CL40 HEK-293T C159(1.11); C248(0.97)  LDD1634  [9]
 LDCM0431  CL41 HEK-293T C248(1.33)  LDD1635  [9]
 LDCM0432  CL42 HEK-293T C159(1.49); C723(0.89)  LDD1636  [9]
 LDCM0433  CL43 HEK-293T C723(1.17); C248(1.11)  LDD1637  [9]
 LDCM0435  CL45 HEK-293T C723(1.31)  LDD1639  [9]
 LDCM0436  CL46 PaTu 8988t C248(1.32)  LDD1315  [6]
 LDCM0437  CL47 PaTu 8988t C248(0.68)  LDD1316  [6]
 LDCM0438  CL48 PaTu 8988t C248(1.04)  LDD1317  [6]
 LDCM0439  CL49 PaTu 8988t C248(0.92)  LDD1318  [6]
 LDCM0440  CL5 HEK-293T C248(1.32)  LDD1644  [9]
 LDCM0441  CL50 PaTu 8988t C248(0.70)  LDD1320  [6]
 LDCM0442  CL51 PaTu 8988t C248(0.82)  LDD1321  [6]
 LDCM0443  CL52 PaTu 8988t C248(1.01)  LDD1322  [6]
 LDCM0444  CL53 PaTu 8988t C248(0.70)  LDD1323  [6]
 LDCM0445  CL54 PaTu 8988t C248(0.71)  LDD1324  [6]
 LDCM0446  CL55 PaTu 8988t C248(1.31)  LDD1325  [6]
 LDCM0447  CL56 PaTu 8988t C248(0.97)  LDD1326  [6]
 LDCM0448  CL57 PaTu 8988t C248(1.11)  LDD1327  [6]
 LDCM0449  CL58 PaTu 8988t C248(0.87)  LDD1328  [6]
 LDCM0450  CL59 PaTu 8988t C248(2.03)  LDD1329  [6]
 LDCM0451  CL6 HEK-293T C159(1.17); C723(1.02)  LDD1654  [9]
 LDCM0452  CL60 PaTu 8988t C248(0.74)  LDD1331  [6]
 LDCM0453  CL61 HEK-293T C159(1.03); C723(1.03)  LDD1656  [9]
 LDCM0454  CL62 HEK-293T C159(0.91)  LDD1657  [9]
 LDCM0456  CL64 HEK-293T C159(1.27); C248(1.16)  LDD1659  [9]
 LDCM0457  CL65 HEK-293T C248(1.09)  LDD1660  [9]
 LDCM0458  CL66 HEK-293T C159(0.74); C723(1.18)  LDD1661  [9]
 LDCM0459  CL67 HEK-293T C723(1.12); C248(1.01)  LDD1662  [9]
 LDCM0461  CL69 HEK-293T C723(1.28)  LDD1664  [9]
 LDCM0462  CL7 HEK-293T C723(1.24); C248(1.16)  LDD1665  [9]
 LDCM0463  CL70 HEK-293T C159(1.14); C723(0.93)  LDD1666  [9]
 LDCM0464  CL71 HEK-293T C723(0.99)  LDD1667  [9]
 LDCM0465  CL72 HEK-293T C159(1.20); C723(1.05)  LDD1668  [9]
 LDCM0466  CL73 HEK-293T C159(1.05); C723(1.04)  LDD1669  [9]
 LDCM0467  CL74 HEK-293T C159(0.93)  LDD1670  [9]
 LDCM0469  CL76 HEK-293T C159(1.16); C248(0.84)  LDD1672  [9]
 LDCM0470  CL77 HEK-293T C248(1.08)  LDD1673  [9]
 LDCM0471  CL78 HEK-293T C159(1.06); C723(1.29)  LDD1674  [9]
 LDCM0472  CL79 HEK-293T C723(1.04); C248(0.97)  LDD1675  [9]
 LDCM0475  CL81 HEK-293T C723(1.23)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C159(1.10); C723(0.95)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C723(0.98)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C159(1.14); C723(1.02)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C159(1.02); C723(1.10)  LDD1682  [9]
 LDCM0480  CL86 HEK-293T C159(0.99)  LDD1683  [9]
 LDCM0482  CL88 HEK-293T C159(1.13); C248(0.98)  LDD1685  [9]
 LDCM0483  CL89 HEK-293T C248(1.40)  LDD1686  [9]
 LDCM0484  CL9 HEK-293T C723(1.24)  LDD1687  [9]
 LDCM0485  CL90 HEK-293T C159(1.21); C723(1.21)  LDD1688  [9]
 LDCM0486  CL91 HEK-293T C723(1.06); C248(1.13)  LDD1689  [9]
 LDCM0488  CL93 HEK-293T C723(1.13)  LDD1691  [9]
 LDCM0489  CL94 HEK-293T C159(1.06); C723(1.01)  LDD1692  [9]
 LDCM0490  CL95 HEK-293T C723(1.06)  LDD1693  [9]
 LDCM0491  CL96 HEK-293T C159(1.09); C723(0.98)  LDD1694  [9]
 LDCM0492  CL97 HEK-293T C159(1.00); C723(1.06)  LDD1695  [9]
 LDCM0493  CL98 HEK-293T C159(1.00)  LDD1696  [9]
 LDCM0427  Fragment51 HEK-293T C159(0.94)  LDD1631  [9]
 LDCM0022  KB02 A101D C248(1.82)  LDD2250  [10]
 LDCM0023  KB03 MDA-MB-231 C723(0.54)  LDD1701  [4]
 LDCM0024  KB05 MKN45 C627(2.75)  LDD3332  [10]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C370(0.81)  LDD2150  [4]
 LDCM0021  THZ1 HCT 116 C248(0.72)  LDD2173  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Peroxisomal ATPase PEX1 (PEX1) AAA ATPase family O43933
RING finger and CHY zinc finger domain-containing protein 1 (RCHY1) . Q96PM5
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Wolframin (WFS1) . O76024
Other
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin, type I cytoskeletal 16 (KRT16) Intermediate filament family P08779
Keratin, type I cytoskeletal 27 (KRT27) Intermediate filament family Q7Z3Y8
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) NOTCH family Q7Z3S9
Notch homolog 2 N-terminal-like protein C (NOTCH2NLC) NOTCH family P0DPK4
Paraneoplastic antigen Ma1 (PNMA1) PNMA family Q8ND90
Heat shock factor 2-binding protein (HSF2BP) . O75031

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840