Details of the Target

General Information of Target

Target ID LDTP11428
Target Name S phase cyclin A-associated protein in the endoplasmic reticulum (SCAPER)
Gene Name SCAPER
Gene ID 49855
Synonyms
KIAA1454; ZNF291; S phase cyclin A-associated protein in the endoplasmic reticulum; S phase cyclin A-associated protein in the ER; Zinc finger protein 291
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSSSYDEASLAPEETTDSFWEVGNYKRTVKRIDDGHRLCNDLMNCVQERAKIEKAYGQQL
TDWAKRWRQLIEKGPQYGSLERAWGAIMTEADKVSELHQEVKNNLLNEDLEKVKNWQKDA
YHKQIMGGFKETKEAEDGFRKAQKPWAKKMKELEAAKKAYHLACKEEKLAMTREMNSKTE
QSVTPEQQKKLQDKVDKCKQDVQKTQEKYEKVLEDVGKTTPQYMENMEQVFEQCQQFEEK
RLVFLKEVLLDIKRHLNLAENSSYIHVYRELEQAIRGADAQEDLRWFRSTSGPGMPMNWP
QFEEWNPDLPHTTTKKEKQPKKAEGVALTNATGAVESTSQAGDRGSVSSYDRGQPYATEW
SDDESGNPFGGSETNGGANPFEDDSKGVRVRALYDYDGQEQDELSFKAGDELTKLGEEDE
QGWCRGRLDSGQLGLYPANYVEAI
Target Bioclass
Other
Subcellular location
Endoplasmic reticulum
Function CCNA2/CDK2 regulatory protein that transiently maintains CCNA2 in the cytoplasm.
Uniprot ID
Q9BY12
Ensemble ID
ENST00000324767.11
HGNC ID
HGNC:13081

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA Insertion: p.I875DfsTer10 .
HS936T SNV: p.R718W .
HT115 SNV: p.K893T .
IM95 Insertion: p.N868KfsTer2 .
JHH7 Deletion: p.V820Ter .
KMS11 SNV: p.F5L .
MCC13 SNV: p.P855S DBIA    Probe Info 
MFE296 SNV: p.R1068Ter .
NCIH1155 SNV: p.V119I .
RL952 SNV: p.F1234C .
SKMEL2 SNV: p.T289A .
SNGM SNV: p.R431C .
SNU1 Deletion: p.N1328del .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K666(6.25)  LDD0277  [1]
AHL-Pu-1
 Probe Info  		C304(2.16)  LDD0168  [2]
DBIA
 Probe Info  		C71(1.95)  LDD0080  [3]
IA-alkyne
 Probe Info  		C71(0.00); C1301(0.00)  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
IPM
 Probe Info  		C1369(0.00); C336(0.00)  LDD2156  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C304(2.16)  LDD0168  [2]
 LDCM0214  AC1 HEK-293T C121(1.13); C130(0.92)  LDD0812  [3]
 LDCM0215  AC10 HEK-293T C121(0.94); C130(0.93)  LDD0813  [3]
 LDCM0216  AC100 HEK-293T C121(0.95); C130(1.03); C71(1.05)  LDD0814  [3]
 LDCM0217  AC101 HEK-293T C121(0.90); C130(1.01); C71(0.91)  LDD0815  [3]
 LDCM0218  AC102 HEK-293T C121(0.97); C130(0.98); C71(1.02)  LDD0816  [3]
 LDCM0219  AC103 HEK-293T C121(0.89); C130(1.07); C71(1.11)  LDD0817  [3]
 LDCM0220  AC104 HEK-293T C121(0.87); C130(0.93); C71(1.00)  LDD0818  [3]
 LDCM0221  AC105 HEK-293T C121(1.10); C130(0.96); C71(1.17)  LDD0819  [3]
 LDCM0222  AC106 HEK-293T C121(1.25); C130(1.13); C71(1.13)  LDD0820  [3]
 LDCM0223  AC107 HEK-293T C121(0.90); C130(1.02); C71(0.95)  LDD0821  [3]
 LDCM0224  AC108 HEK-293T C121(1.04); C130(1.00); C71(1.07)  LDD0822  [3]
 LDCM0225  AC109 HEK-293T C121(1.02); C130(0.97); C71(1.06)  LDD0823  [3]
 LDCM0226  AC11 HEK-293T C121(1.04); C130(1.01)  LDD0824  [3]
 LDCM0227  AC110 HEK-293T C121(0.95); C130(1.26); C71(1.13)  LDD0825  [3]
 LDCM0228  AC111 HEK-293T C121(1.13); C130(1.62); C71(1.05)  LDD0826  [3]
 LDCM0229  AC112 HEK-293T C121(0.98); C130(1.37); C71(0.97)  LDD0827  [3]
 LDCM0230  AC113 HEK-293T C121(0.98); C130(0.98); C71(1.02)  LDD0828  [3]
 LDCM0231  AC114 HEK-293T C121(0.97); C130(0.97); C71(1.00)  LDD0829  [3]
 LDCM0232  AC115 HEK-293T C121(0.80); C130(0.80); C71(0.96)  LDD0830  [3]
 LDCM0233  AC116 HEK-293T C121(0.92); C130(0.92); C71(0.93)  LDD0831  [3]
 LDCM0234  AC117 HEK-293T C121(0.72); C130(0.72); C71(0.96)  LDD0832  [3]
 LDCM0235  AC118 HEK-293T C121(0.68); C130(0.68); C71(0.90)  LDD0833  [3]
 LDCM0236  AC119 HEK-293T C121(0.64); C130(0.64); C71(1.01)  LDD0834  [3]
 LDCM0237  AC12 HEK-293T C121(0.90); C130(0.93)  LDD0835  [3]
 LDCM0238  AC120 HEK-293T C121(0.76); C130(0.76); C71(1.09)  LDD0836  [3]
 LDCM0239  AC121 HEK-293T C121(0.64); C130(0.64); C71(1.20)  LDD0837  [3]
 LDCM0240  AC122 HEK-293T C121(0.75); C130(0.75); C71(1.04)  LDD0838  [3]
 LDCM0241  AC123 HEK-293T C121(0.76); C130(0.76); C71(0.87)  LDD0839  [3]
 LDCM0242  AC124 HEK-293T C121(0.81); C130(0.81); C71(1.19)  LDD0840  [3]
 LDCM0243  AC125 HEK-293T C121(0.92); C130(0.92); C71(1.06)  LDD0841  [3]
 LDCM0244  AC126 HEK-293T C121(0.81); C130(0.81); C71(1.27)  LDD0842  [3]
 LDCM0245  AC127 HEK-293T C121(0.91); C130(0.91); C71(1.08)  LDD0843  [3]
 LDCM0259  AC14 HEK-293T C121(0.90); C130(0.95)  LDD0857  [3]
 LDCM0263  AC143 HEK-293T C121(1.03); C130(1.03); C71(0.94)  LDD0861  [3]
 LDCM0264  AC144 HEK-293T C121(0.80); C130(0.80); C71(1.20)  LDD0862  [3]
 LDCM0265  AC145 HEK-293T C121(0.87); C130(0.87); C71(1.22)  LDD0863  [3]
 LDCM0266  AC146 HEK-293T C121(0.85); C130(0.85); C71(1.11)  LDD0864  [3]
 LDCM0267  AC147 HEK-293T C121(0.92); C130(0.92); C71(1.13)  LDD0865  [3]
 LDCM0268  AC148 HEK-293T C121(0.94); C130(0.94); C71(0.71)  LDD0866  [3]
 LDCM0269  AC149 HEK-293T C121(0.88); C130(0.88); C71(1.28)  LDD0867  [3]
 LDCM0270  AC15 HEK-293T C121(0.78); C130(0.90)  LDD0868  [3]
 LDCM0271  AC150 HEK-293T C121(0.88); C130(0.88); C71(1.11)  LDD0869  [3]
 LDCM0272  AC151 HEK-293T C121(0.80); C130(0.80); C71(1.10)  LDD0870  [3]
 LDCM0273  AC152 HEK-293T C121(0.85); C130(0.85); C71(0.94)  LDD0871  [3]
 LDCM0274  AC153 HEK-293T C121(0.86); C130(0.86); C71(1.01)  LDD0872  [3]
 LDCM0621  AC154 HEK-293T C121(0.82); C130(0.82); C71(1.48)  LDD2162  [3]
 LDCM0622  AC155 HEK-293T C121(0.85); C130(0.85); C71(1.25)  LDD2163  [3]
 LDCM0623  AC156 HEK-293T C121(0.89); C130(0.89); C71(1.02)  LDD2164  [3]
 LDCM0624  AC157 HEK-293T C121(0.99); C130(0.99); C71(1.16)  LDD2165  [3]
 LDCM0276  AC17 HCT 116 C121(0.98); C130(0.98)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C121(3.20); C130(3.20)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C121(0.79); C130(0.79)  LDD0595  [3]
 LDCM0279  AC2 HEK-293T C121(1.00); C130(0.95)  LDD0877  [3]
 LDCM0280  AC20 HCT 116 C121(0.84); C130(0.84)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C121(0.87); C130(0.87)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C121(1.23); C130(1.23)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C121(1.05); C130(1.05)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C121(0.73); C130(0.73)  LDD0601  [3]
 LDCM0285  AC25 HEK-293T C121(0.79); C130(0.66)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C121(0.68); C130(0.55)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C121(0.74); C130(0.66)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C121(0.55); C130(0.68)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C121(0.64); C130(0.56)  LDD0887  [3]
 LDCM0290  AC3 HEK-293T C121(1.35); C130(1.05)  LDD0888  [3]
 LDCM0291  AC30 HEK-293T C121(0.71); C130(0.62)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C121(0.71); C130(0.61)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C121(0.72); C130(0.63)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C121(0.70); C130(0.57)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C121(0.74); C130(0.68)  LDD0893  [3]
 LDCM0296  AC35 HEK-293T C121(1.07); C130(1.07)  LDD0894  [3]
 LDCM0297  AC36 HEK-293T C121(0.90); C130(0.90)  LDD0895  [3]
 LDCM0298  AC37 HEK-293T C121(0.85); C130(0.85)  LDD0896  [3]
 LDCM0299  AC38 HEK-293T C121(0.79); C130(0.79)  LDD0897  [3]
 LDCM0300  AC39 HEK-293T C121(0.88); C130(0.88)  LDD0898  [3]
 LDCM0301  AC4 HEK-293T C121(1.39); C130(1.04)  LDD0899  [3]
 LDCM0302  AC40 HEK-293T C121(0.88); C130(0.88)  LDD0900  [3]
 LDCM0303  AC41 HEK-293T C121(1.20); C130(1.20)  LDD0901  [3]
 LDCM0304  AC42 HEK-293T C121(0.86); C130(0.86)  LDD0902  [3]
 LDCM0305  AC43 HEK-293T C121(1.06); C130(1.06)  LDD0903  [3]
 LDCM0306  AC44 HEK-293T C121(0.84); C130(0.84)  LDD0904  [3]
 LDCM0307  AC45 HEK-293T C121(0.89); C130(0.89)  LDD0905  [3]
 LDCM0308  AC46 HEK-293T C121(0.92); C130(0.96)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C121(0.80); C130(0.81)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C121(0.77); C130(0.79)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C121(0.70); C130(0.65)  LDD0909  [3]
 LDCM0312  AC5 HEK-293T C121(1.23); C130(0.99)  LDD0910  [3]
 LDCM0313  AC50 HEK-293T C121(0.73); C130(0.74)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C121(0.71); C130(0.72)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C121(0.67); C130(0.71)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C121(0.77); C130(0.78)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C121(0.71); C130(0.67)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C121(0.72); C130(0.71)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C121(0.81); C130(0.82)  LDD0917  [3]
 LDCM0320  AC57 HEK-293T C71(1.14)  LDD0918  [3]
 LDCM0321  AC58 HEK-293T C71(1.51)  LDD0919  [3]
 LDCM0322  AC59 HEK-293T C71(1.33)  LDD0920  [3]
 LDCM0323  AC6 HEK-293T C121(0.93); C130(0.87)  LDD0921  [3]
 LDCM0324  AC60 HEK-293T C71(0.77)  LDD0922  [3]
 LDCM0325  AC61 HEK-293T C71(1.11)  LDD0923  [3]
 LDCM0326  AC62 HEK-293T C71(1.15)  LDD0924  [3]
 LDCM0327  AC63 HEK-293T C71(1.00)  LDD0925  [3]
 LDCM0328  AC64 HEK-293T C71(2.06)  LDD0926  [3]
 LDCM0329  AC65 HEK-293T C71(0.71)  LDD0927  [3]
 LDCM0330  AC66 HEK-293T C71(1.10)  LDD0928  [3]
 LDCM0331  AC67 HEK-293T C71(1.15)  LDD0929  [3]
 LDCM0332  AC68 HEK-293T C130(1.06); C71(0.77)  LDD0930  [3]
 LDCM0333  AC69 HEK-293T C130(1.18); C71(0.66)  LDD0931  [3]
 LDCM0334  AC7 HEK-293T C121(0.83); C130(0.88)  LDD0932  [3]
 LDCM0335  AC70 HEK-293T C130(1.31); C71(0.82)  LDD0933  [3]
 LDCM0336  AC71 HEK-293T C130(1.04); C71(0.89)  LDD0934  [3]
 LDCM0337  AC72 HEK-293T C130(1.15); C71(0.86)  LDD0935  [3]
 LDCM0338  AC73 HEK-293T C130(1.24); C71(0.77)  LDD0936  [3]
 LDCM0339  AC74 HEK-293T C130(1.25); C71(0.59)  LDD0937  [3]
 LDCM0340  AC75 HEK-293T C130(1.03); C71(0.76)  LDD0938  [3]
 LDCM0341  AC76 HEK-293T C130(1.11); C71(0.48)  LDD0939  [3]
 LDCM0342  AC77 HEK-293T C130(1.09); C71(0.69)  LDD0940  [3]
 LDCM0343  AC78 HEK-293T C130(1.15); C71(0.67)  LDD0941  [3]
 LDCM0344  AC79 HEK-293T C130(1.12); C71(0.67)  LDD0942  [3]
 LDCM0345  AC8 HEK-293T C121(0.78); C130(0.84)  LDD0943  [3]
 LDCM0346  AC80 HEK-293T C130(1.16); C71(0.85)  LDD0944  [3]
 LDCM0347  AC81 HEK-293T C130(1.08); C71(0.60)  LDD0945  [3]
 LDCM0348  AC82 HEK-293T C130(1.47); C71(1.18)  LDD0946  [3]
 LDCM0349  AC83 HEK-293T C121(0.84); C130(0.92); C71(1.12)  LDD0947  [3]
 LDCM0350  AC84 HEK-293T C121(0.59); C130(0.95); C71(1.61)  LDD0948  [3]
 LDCM0351  AC85 HEK-293T C121(0.63); C130(0.96); C71(1.23)  LDD0949  [3]
 LDCM0352  AC86 HEK-293T C121(0.64); C130(0.90); C71(1.15)  LDD0950  [3]
 LDCM0353  AC87 HEK-293T C121(0.61); C130(0.94); C71(1.02)  LDD0951  [3]
 LDCM0354  AC88 HEK-293T C121(0.60); C130(1.05); C71(1.13)  LDD0952  [3]
 LDCM0355  AC89 HEK-293T C121(0.57); C130(1.14); C71(1.21)  LDD0953  [3]
 LDCM0357  AC90 HEK-293T C121(0.61); C130(1.00); C71(1.23)  LDD0955  [3]
 LDCM0358  AC91 HEK-293T C121(0.59); C130(1.03); C71(1.41)  LDD0956  [3]
 LDCM0359  AC92 HEK-293T C121(0.69); C130(0.99); C71(0.94)  LDD0957  [3]
 LDCM0360  AC93 HEK-293T C121(0.70); C130(0.99); C71(1.15)  LDD0958  [3]
 LDCM0361  AC94 HEK-293T C121(0.58); C130(1.09); C71(2.03)  LDD0959  [3]
 LDCM0362  AC95 HEK-293T C121(0.58); C130(1.05); C71(1.31)  LDD0960  [3]
 LDCM0363  AC96 HEK-293T C121(0.82); C130(1.13); C71(1.12)  LDD0961  [3]
 LDCM0364  AC97 HEK-293T C121(0.68); C130(1.64); C71(1.19)  LDD0962  [3]
 LDCM0365  AC98 HEK-293T C121(1.01); C130(1.01); C71(0.86)  LDD0963  [3]
 LDCM0366  AC99 HEK-293T C121(1.06); C130(1.04); C71(1.00)  LDD0964  [3]
 LDCM0248  AKOS034007472 HEK-293T C121(0.88); C130(0.89)  LDD0846  [3]
 LDCM0356  AKOS034007680 HEK-293T C121(0.71); C130(0.88)  LDD0954  [3]
 LDCM0275  AKOS034007705 HEK-293T C121(0.75); C130(0.91)  LDD0873  [3]
 LDCM0367  CL1 HCT 116 C121(1.14); C130(1.14)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C121(0.92); C130(0.92)  LDD0685  [3]
 LDCM0369  CL100 HEK-293T C121(1.07); C130(0.85)  LDD0967  [3]
 LDCM0370  CL101 HEK-293T C121(0.75); C130(0.87)  LDD0968  [3]
 LDCM0371  CL102 HEK-293T C121(0.67); C130(0.87)  LDD0969  [3]
 LDCM0372  CL103 HEK-293T C121(0.74); C130(0.89)  LDD0970  [3]
 LDCM0373  CL104 HEK-293T C121(0.77); C130(0.83)  LDD0971  [3]
 LDCM0374  CL105 HCT 116 C121(1.03); C130(1.03)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C121(1.21); C130(1.21)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C121(1.41); C130(1.41)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C121(1.03); C130(1.03)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C121(1.09); C130(1.09)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C121(1.15); C130(1.15)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C121(1.11); C130(1.11)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C121(0.86); C130(0.86)  LDD0698  [3]
 LDCM0382  CL112 HEK-293T C121(0.65); C130(0.62)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C121(0.75); C130(0.72)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C121(0.52); C130(0.45)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C121(0.63); C130(0.60)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C121(0.60); C130(0.48)  LDD0984  [3]
 LDCM0387  CL117 HEK-293T C121(0.93); C130(0.93)  LDD0985  [3]
 LDCM0388  CL118 HEK-293T C121(0.86); C130(0.86)  LDD0986  [3]
 LDCM0389  CL119 HEK-293T C121(0.88); C130(0.88)  LDD0987  [3]
 LDCM0390  CL12 HCT 116 C121(1.06); C130(1.06)  LDD0707  [3]
 LDCM0391  CL120 HEK-293T C121(0.90); C130(0.90)  LDD0989  [3]
 LDCM0392  CL121 HEK-293T C121(0.76); C130(0.82)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C121(0.78); C130(0.78)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C121(0.69); C130(0.72)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C121(0.71); C130(0.70)  LDD0993  [3]
 LDCM0396  CL125 HEK-293T C71(0.97)  LDD0994  [3]
 LDCM0397  CL126 HEK-293T C71(1.46)  LDD0995  [3]
 LDCM0398  CL127 HEK-293T C71(1.15)  LDD0996  [3]
 LDCM0399  CL128 HEK-293T C71(1.54)  LDD0997  [3]
 LDCM0400  CL13 HCT 116 C121(0.95); C130(0.95)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C121(0.94); C130(0.94)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C121(0.98); C130(0.98)  LDD0719  [3]
 LDCM0403  CL16 HEK-293T C121(0.99); C130(0.99)  LDD1001  [3]
 LDCM0404  CL17 HEK-293T C121(0.93); C130(0.93)  LDD1002  [3]
 LDCM0405  CL18 HEK-293T C121(0.84); C130(0.84)  LDD1003  [3]
 LDCM0406  CL19 HEK-293T C121(0.86); C130(0.86)  LDD1004  [3]
 LDCM0407  CL2 HCT 116 C121(1.22); C130(1.22)  LDD0724  [3]
 LDCM0408  CL20 HEK-293T C121(0.89); C130(0.89)  LDD1006  [3]
 LDCM0409  CL21 HEK-293T C121(0.94); C130(0.94)  LDD1007  [3]
 LDCM0410  CL22 HEK-293T C121(0.80); C130(0.80)  LDD1008  [3]
 LDCM0411  CL23 HEK-293T C121(0.97); C130(0.97)  LDD1009  [3]
 LDCM0412  CL24 HEK-293T C121(0.95); C130(0.95)  LDD1010  [3]
 LDCM0413  CL25 HEK-293T C121(0.86); C130(0.86)  LDD1011  [3]
 LDCM0414  CL26 HEK-293T C121(1.08); C130(1.08)  LDD1012  [3]
 LDCM0415  CL27 HEK-293T C121(0.87); C130(0.87)  LDD1013  [3]
 LDCM0416  CL28 HEK-293T C121(0.94); C130(0.94)  LDD1014  [3]
 LDCM0417  CL29 HEK-293T C121(0.86); C130(0.86)  LDD1015  [3]
 LDCM0418  CL3 HCT 116 C121(0.79); C130(0.79)  LDD0735  [3]
 LDCM0419  CL30 HEK-293T C121(0.86); C130(0.86)  LDD1017  [3]
 LDCM0420  CL31 HEK-293T C121(0.69); C130(0.69)  LDD1018  [3]
 LDCM0421  CL32 HEK-293T C121(0.79); C130(0.85)  LDD1019  [3]
 LDCM0422  CL33 HEK-293T C121(0.64); C130(0.70)  LDD1020  [3]
 LDCM0423  CL34 HEK-293T C121(0.92); C130(0.84)  LDD1021  [3]
 LDCM0424  CL35 HEK-293T C121(0.58); C130(0.84)  LDD1022  [3]
 LDCM0425  CL36 HEK-293T C121(0.75); C130(0.85)  LDD1023  [3]
 LDCM0426  CL37 HEK-293T C121(0.67); C130(0.92)  LDD1024  [3]
 LDCM0428  CL39 HEK-293T C121(0.50); C130(0.96)  LDD1026  [3]
 LDCM0429  CL4 HCT 116 C121(1.31); C130(1.31)  LDD0746  [3]
 LDCM0430  CL40 HEK-293T C121(0.66); C130(0.83)  LDD1028  [3]
 LDCM0431  CL41 HEK-293T C121(0.50); C130(0.89)  LDD1029  [3]
 LDCM0432  CL42 HEK-293T C121(0.50); C130(0.94)  LDD1030  [3]
 LDCM0433  CL43 HEK-293T C121(0.49); C130(0.86)  LDD1031  [3]
 LDCM0434  CL44 HEK-293T C121(0.58); C130(0.80)  LDD1032  [3]
 LDCM0435  CL45 HEK-293T C121(0.48); C130(0.85)  LDD1033  [3]
 LDCM0436  CL46 HCT 116 C121(0.81); C130(0.81)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C121(0.79); C130(0.79)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C121(1.08); C130(1.08)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C121(1.02); C130(1.02)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C121(1.25); C130(1.25)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C121(1.10); C130(1.10)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C121(0.92); C130(0.92)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C121(0.96); C130(0.96)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C121(0.96); C130(0.96)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C121(1.12); C130(1.12)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C121(1.07); C130(1.07)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C121(0.98); C130(0.98)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C121(0.82); C130(0.82)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C121(0.92); C130(0.92)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C121(1.04); C130(1.04)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C121(0.98); C130(0.98)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C121(0.73); C130(0.73)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C121(0.73); C130(0.73)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C121(0.85); C130(0.85)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C121(0.93); C130(0.93)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C121(0.99); C130(0.99)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C121(1.18); C130(1.18)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C121(1.37); C130(1.37)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C121(0.96); C130(0.96)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C121(1.03); C130(1.03)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C121(0.74); C130(0.74)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C121(0.88); C130(0.88)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C121(0.97); C130(0.97)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C121(1.15); C130(1.15)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C121(0.97); C130(0.97)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C121(0.80); C130(0.80)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C121(1.10); C130(1.10)  LDD0784  [3]
 LDCM0469  CL76 HEK-293T C121(0.99); C130(0.90)  LDD1067  [3]
 LDCM0470  CL77 HEK-293T C121(0.86); C130(0.71)  LDD1068  [3]
 LDCM0471  CL78 HEK-293T C121(0.77); C130(0.66)  LDD1069  [3]
 LDCM0472  CL79 HEK-293T C121(0.76); C130(0.75)  LDD1070  [3]
 LDCM0473  CL8 HCT 116 C121(1.33); C130(1.33)  LDD0790  [3]
 LDCM0474  CL80 HEK-293T C121(0.81); C130(0.72)  LDD1072  [3]
 LDCM0475  CL81 HEK-293T C121(0.80); C130(0.72)  LDD1073  [3]
 LDCM0476  CL82 HEK-293T C121(0.98); C130(1.09)  LDD1074  [3]
 LDCM0477  CL83 HEK-293T C121(0.98); C130(0.93)  LDD1075  [3]
 LDCM0478  CL84 HEK-293T C121(0.83); C130(0.69)  LDD1076  [3]
 LDCM0479  CL85 HEK-293T C121(0.74); C130(0.71)  LDD1077  [3]
 LDCM0480  CL86 HEK-293T C121(0.68); C130(0.67)  LDD1078  [3]
 LDCM0481  CL87 HEK-293T C121(0.78); C130(0.71)  LDD1079  [3]
 LDCM0482  CL88 HEK-293T C121(0.84); C130(0.81)  LDD1080  [3]
 LDCM0483  CL89 HEK-293T C121(0.87); C130(0.81)  LDD1081  [3]
 LDCM0484  CL9 HCT 116 C121(1.03); C130(1.03)  LDD0801  [3]
 LDCM0485  CL90 HEK-293T C121(0.89); C130(0.67)  LDD1083  [3]
 LDCM0486  CL91 HEK-293T C121(1.28); C130(0.89)  LDD1084  [3]
 LDCM0487  CL92 HEK-293T C121(1.43); C130(0.98)  LDD1085  [3]
 LDCM0488  CL93 HEK-293T C121(1.21); C130(0.90)  LDD1086  [3]
 LDCM0489  CL94 HEK-293T C121(1.14); C130(0.98)  LDD1087  [3]
 LDCM0490  CL95 HEK-293T C121(0.97); C130(0.81)  LDD1088  [3]
 LDCM0491  CL96 HEK-293T C121(1.11); C130(0.90)  LDD1089  [3]
 LDCM0492  CL97 HEK-293T C121(1.08); C130(0.87)  LDD1090  [3]
 LDCM0493  CL98 HEK-293T C121(1.07); C130(0.84)  LDD1091  [3]
 LDCM0494  CL99 HEK-293T C121(1.31); C130(0.93)  LDD1092  [3]
 LDCM0495  E2913 HEK-293T C71(1.21); C1369(1.03); C304(1.08)  LDD1698  [6]
 LDCM0468  Fragment33 HCT 116 C121(1.18); C130(1.18)  LDD0785  [3]
 LDCM0427  Fragment51 HEK-293T C121(0.73); C130(0.78)  LDD1025  [3]
 LDCM0022  KB02 HCT 116 C71(1.95)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C71(1.42)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C71(2.00)  LDD0082  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Beta-secretase 2 (BACE2) Peptidase A1 family Q9Y5Z0
Kallikrein-6 (KLK6) Peptidase S1 family Q92876
Cyclin-dependent kinase 2 (CDK2) CMGC Ser/Thr protein kinase family P24941
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
GTPase HRas (HRAS) Ras family P01112
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Nucleoporin p58/p45 (NUP58) NUP58 family Q9BVL2
Alpha-crystallin A chain (CRYAA) Small heat shock protein (HSP20) family P02489
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Krueppel-like factor 11 (KLF11) Sp1 C2H2-type zinc-finger protein family O14901
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) Dynein heavy chain family Q14204
Ganglioside-induced differentiation-associated protein 1 (GDAP1) GST superfamily Q8TB36
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Merlin (NF2) . P35240
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402