Details of the Target

General Information of Target

Target ID LDTP11149
Target Name Endosomal/lysosomal proton channel TMEM175 (TMEM175)
Gene Name TMEM175
Gene ID 84286
Synonyms
Endosomal/lysosomal proton channel TMEM175; Potassium channel TMEM175; Transmembrane protein 175; hTMEM175
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQAARVDYIAPWWVVWLHSVPHVGLRLQPVNSTFSPGDESYQESLLFLGLVAAVCLGLNL
IFLVAYLVCACHCRRDDAVQTKQHHSCCITWTAVVAGLICCAAVGVGFYGNSETNDGAYQ
LMYSLDDANHTFSGIDALVSGTTQKMKVDLEQHLARLSEIFAARGDYLQTLKFIQQMAGS
VVVQLSGLPVWREVTMELTKLSDQTGYVEYYRWLSYLLLFILDLVICLIACLGLAKRSKC
LLASMLCCGALSLLLSWASLAADGSAAVATSDFCVAPDTFILNVTEGQISTEVTRYYLYC
SQSGSSPFQQTLTTFQRALTTMQIQVAGLLQFAVPLFSTAEEDLLAIQLLLNSSESSLHQ
LTAMVDCRGLHKDYLDALAGICYDGLQGLLYLGLFSFLAALAFSTMICAGPRAWKHFTTR
NRDYDDIDDDDPFNPQAWRMAAHSPPRGQLHSFCSYSSGLGSQTSLQPPAQTISNAPVSE
YMNQAMLFGRNPRYENVPLIGRASPPPTYSPSMRATYLSVADEHLRHYGNQFPA
Target Bioclass
Transporter and channel
Family
TMEM175 family
Subcellular location
Endosome membrane
Function
Proton-activated proton channel that catalyzes proton efflux from endosomes and lysosomes to maintain a steady-state pH. Activated at low pH (under pH 4.6) by luminal side protons: selectively mediates lysosomal proton release from lysosomes, eliciting a proton leak that balances V-ATPase activity to maintain pH homeostasis. Regulation of lumenal pH stability is required for autophagosome-lysosome fusion. Also acts as a potassium channel at higher pH, regulating potassium conductance in endosomes and lysosomes. Constitutes the pore-forming subunit of the lysoK(GF) complex, a complex activated by extracellular growth factors. The lysoK(GF) complex is composed of TMEM175 and AKT (AKT1, AKT2 or AKT3), a major target of growth factor receptors: in the complex, TMEM175 channel is opened by conformational changes by AKT, leading to its activation. The lysoK(GF) complex is required to protect neurons against stress-induced damage.
Uniprot ID
Q9BSA9
Ensemble ID
ENST00000264771.9
HGNC ID
HGNC:28709

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL62 SNV: p.T472P .
COLO320 SNV: p.T13K .
HCT15 SNV: p.E403D .
HEC1 SNV: p.K289N .
JURKAT SNV: p.C144S; p.V207I; p.A358S .
LNCaP clone FGC SNV: p.Y313C DBIA    Probe Info 
NCIH2172 SNV: p.D41E .
SKOV3 SNV: p.A471V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C32(1.06)  LDD3323  [1]
IPM
 Probe Info  		C230(1.05)  LDD1701  [2]
Acrolein
 Probe Info  		N.A.  LDD0222  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [4]
ENE
 Probe Info  		N.A.  LDD0006  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C32(1.02)  LDD0812  [6]
 LDCM0215  AC10 HEK-293T C32(0.82)  LDD0813  [6]
 LDCM0216  AC100 HEK-293T C32(1.82)  LDD0814  [6]
 LDCM0217  AC101 HEK-293T C32(1.49)  LDD0815  [6]
 LDCM0218  AC102 HEK-293T C32(1.55)  LDD0816  [6]
 LDCM0219  AC103 HEK-293T C32(1.99)  LDD0817  [6]
 LDCM0220  AC104 HEK-293T C32(1.62)  LDD0818  [6]
 LDCM0221  AC105 HEK-293T C32(1.25)  LDD0819  [6]
 LDCM0222  AC106 HEK-293T C32(1.11)  LDD0820  [6]
 LDCM0223  AC107 HEK-293T C32(1.44)  LDD0821  [6]
 LDCM0224  AC108 HEK-293T C32(1.30)  LDD0822  [6]
 LDCM0225  AC109 HEK-293T C32(1.19)  LDD0823  [6]
 LDCM0226  AC11 HEK-293T C32(0.76)  LDD0824  [6]
 LDCM0227  AC110 HEK-293T C32(2.29)  LDD0825  [6]
 LDCM0228  AC111 HEK-293T C32(3.82)  LDD0826  [6]
 LDCM0229  AC112 HEK-293T C32(2.83)  LDD0827  [6]
 LDCM0230  AC113 HEK-293T C32(1.18)  LDD0828  [6]
 LDCM0231  AC114 HEK-293T C32(0.97)  LDD0829  [6]
 LDCM0232  AC115 HEK-293T C32(0.95)  LDD0830  [6]
 LDCM0233  AC116 HEK-293T C32(0.94)  LDD0831  [6]
 LDCM0234  AC117 HEK-293T C32(1.11)  LDD0832  [6]
 LDCM0235  AC118 HEK-293T C32(0.90)  LDD0833  [6]
 LDCM0236  AC119 HEK-293T C32(1.15)  LDD0834  [6]
 LDCM0237  AC12 HEK-293T C32(1.07)  LDD0835  [6]
 LDCM0238  AC120 HEK-293T C32(1.02)  LDD0836  [6]
 LDCM0239  AC121 HEK-293T C32(1.30)  LDD0837  [6]
 LDCM0240  AC122 HEK-293T C32(1.62)  LDD0838  [6]
 LDCM0241  AC123 HEK-293T C32(1.16)  LDD0839  [6]
 LDCM0242  AC124 HEK-293T C32(1.24)  LDD0840  [6]
 LDCM0243  AC125 HEK-293T C32(1.49)  LDD0841  [6]
 LDCM0244  AC126 HEK-293T C32(1.84)  LDD0842  [6]
 LDCM0245  AC127 HEK-293T C32(1.75)  LDD0843  [6]
 LDCM0246  AC128 HEK-293T C32(0.79)  LDD0844  [6]
 LDCM0247  AC129 HEK-293T C32(1.27)  LDD0845  [6]
 LDCM0249  AC130 HEK-293T C32(1.23)  LDD0847  [6]
 LDCM0250  AC131 HEK-293T C32(0.88)  LDD0848  [6]
 LDCM0251  AC132 HEK-293T C32(1.03)  LDD0849  [6]
 LDCM0252  AC133 HEK-293T C32(1.30)  LDD0850  [6]
 LDCM0253  AC134 HEK-293T C32(1.10)  LDD0851  [6]
 LDCM0254  AC135 HEK-293T C32(1.22)  LDD0852  [6]
 LDCM0255  AC136 HEK-293T C32(1.48)  LDD0853  [6]
 LDCM0256  AC137 HEK-293T C32(1.68)  LDD0854  [6]
 LDCM0257  AC138 HEK-293T C32(1.58)  LDD0855  [6]
 LDCM0258  AC139 HEK-293T C32(1.68)  LDD0856  [6]
 LDCM0259  AC14 HEK-293T C32(0.90)  LDD0857  [6]
 LDCM0260  AC140 HEK-293T C32(1.51)  LDD0858  [6]
 LDCM0261  AC141 HEK-293T C32(1.69)  LDD0859  [6]
 LDCM0262  AC142 HEK-293T C32(1.24)  LDD0860  [6]
 LDCM0263  AC143 HEK-293T C32(0.70)  LDD0861  [6]
 LDCM0264  AC144 HEK-293T C32(1.10)  LDD0862  [6]
 LDCM0265  AC145 HEK-293T C32(1.20)  LDD0863  [6]
 LDCM0266  AC146 HEK-293T C32(1.16)  LDD0864  [6]
 LDCM0267  AC147 HEK-293T C32(0.97)  LDD0865  [6]
 LDCM0268  AC148 HEK-293T C32(0.83)  LDD0866  [6]
 LDCM0269  AC149 HEK-293T C32(0.85)  LDD0867  [6]
 LDCM0270  AC15 HEK-293T C32(1.15)  LDD0868  [6]
 LDCM0271  AC150 HEK-293T C32(0.86)  LDD0869  [6]
 LDCM0272  AC151 HEK-293T C32(1.04)  LDD0870  [6]
 LDCM0273  AC152 HEK-293T C32(0.86)  LDD0871  [6]
 LDCM0274  AC153 HEK-293T C32(0.83)  LDD0872  [6]
 LDCM0621  AC154 HEK-293T C32(0.87)  LDD2162  [6]
 LDCM0622  AC155 HEK-293T C32(0.83)  LDD2163  [6]
 LDCM0623  AC156 HEK-293T C32(1.12)  LDD2164  [6]
 LDCM0624  AC157 HEK-293T C32(1.35)  LDD2165  [6]
 LDCM0276  AC17 HEK-293T C32(1.71)  LDD0874  [6]
 LDCM0277  AC18 HEK-293T C32(1.54)  LDD0875  [6]
 LDCM0278  AC19 HEK-293T C32(1.34)  LDD0876  [6]
 LDCM0279  AC2 HEK-293T C32(0.97)  LDD0877  [6]
 LDCM0280  AC20 HEK-293T C32(1.88)  LDD0878  [6]
 LDCM0281  AC21 HEK-293T C32(2.28)  LDD0879  [6]
 LDCM0282  AC22 HEK-293T C32(1.47)  LDD0880  [6]
 LDCM0283  AC23 HEK-293T C32(2.32)  LDD0881  [6]
 LDCM0284  AC24 HEK-293T C32(1.13)  LDD0882  [6]
 LDCM0285  AC25 HEK-293T C32(1.18)  LDD0883  [6]
 LDCM0286  AC26 HEK-293T C32(1.76)  LDD0884  [6]
 LDCM0287  AC27 HEK-293T C32(1.49)  LDD0885  [6]
 LDCM0288  AC28 HEK-293T C32(2.39)  LDD0886  [6]
 LDCM0289  AC29 HEK-293T C32(1.27)  LDD0887  [6]
 LDCM0290  AC3 HEK-293T C32(0.72)  LDD0888  [6]
 LDCM0291  AC30 HEK-293T C32(1.03)  LDD0889  [6]
 LDCM0292  AC31 HEK-293T C32(1.20)  LDD0890  [6]
 LDCM0293  AC32 HEK-293T C32(0.95)  LDD0891  [6]
 LDCM0294  AC33 HEK-293T C32(1.22)  LDD0892  [6]
 LDCM0295  AC34 HEK-293T C32(0.96)  LDD0893  [6]
 LDCM0296  AC35 HEK-293T C32(0.97)  LDD0894  [6]
 LDCM0297  AC36 HEK-293T C32(1.18)  LDD0895  [6]
 LDCM0298  AC37 HEK-293T C32(1.30)  LDD0896  [6]
 LDCM0299  AC38 HEK-293T C32(1.97)  LDD0897  [6]
 LDCM0300  AC39 HEK-293T C32(1.56)  LDD0898  [6]
 LDCM0301  AC4 HEK-293T C32(0.81)  LDD0899  [6]
 LDCM0302  AC40 HEK-293T C32(1.38)  LDD0900  [6]
 LDCM0303  AC41 HEK-293T C32(1.12)  LDD0901  [6]
 LDCM0304  AC42 HEK-293T C32(2.28)  LDD0902  [6]
 LDCM0305  AC43 HEK-293T C32(1.15)  LDD0903  [6]
 LDCM0306  AC44 HEK-293T C32(1.26)  LDD0904  [6]
 LDCM0307  AC45 HEK-293T C32(1.16)  LDD0905  [6]
 LDCM0308  AC46 HEK-293T C32(1.22)  LDD0906  [6]
 LDCM0309  AC47 HEK-293T C32(1.09)  LDD0907  [6]
 LDCM0310  AC48 HEK-293T C32(1.06)  LDD0908  [6]
 LDCM0311  AC49 HEK-293T C32(1.30)  LDD0909  [6]
 LDCM0312  AC5 HEK-293T C32(1.06)  LDD0910  [6]
 LDCM0313  AC50 HEK-293T C32(1.37)  LDD0911  [6]
 LDCM0314  AC51 HEK-293T C32(1.36)  LDD0912  [6]
 LDCM0315  AC52 HEK-293T C32(1.46)  LDD0913  [6]
 LDCM0316  AC53 HEK-293T C32(1.32)  LDD0914  [6]
 LDCM0317  AC54 HEK-293T C32(1.24)  LDD0915  [6]
 LDCM0318  AC55 HEK-293T C32(1.25)  LDD0916  [6]
 LDCM0319  AC56 HEK-293T C32(1.09)  LDD0917  [6]
 LDCM0320  AC57 HEK-293T C32(1.24)  LDD0918  [6]
 LDCM0321  AC58 HEK-293T C32(0.85)  LDD0919  [6]
 LDCM0322  AC59 HEK-293T C32(1.19)  LDD0920  [6]
 LDCM0323  AC6 HEK-293T C32(1.22)  LDD0921  [6]
 LDCM0324  AC60 HEK-293T C32(1.30)  LDD0922  [6]
 LDCM0325  AC61 HEK-293T C32(1.14)  LDD0923  [6]
 LDCM0326  AC62 HEK-293T C32(0.87)  LDD0924  [6]
 LDCM0327  AC63 HEK-293T C32(1.02)  LDD0925  [6]
 LDCM0328  AC64 HEK-293T C32(0.95)  LDD0926  [6]
 LDCM0329  AC65 HEK-293T C32(1.09)  LDD0927  [6]
 LDCM0330  AC66 HEK-293T C32(0.78)  LDD0928  [6]
 LDCM0331  AC67 HEK-293T C32(0.80)  LDD0929  [6]
 LDCM0332  AC68 HEK-293T C32(0.88)  LDD0930  [6]
 LDCM0333  AC69 HEK-293T C32(0.96)  LDD0931  [6]
 LDCM0334  AC7 HEK-293T C32(1.29)  LDD0932  [6]
 LDCM0335  AC70 HEK-293T C32(1.08)  LDD0933  [6]
 LDCM0336  AC71 HEK-293T C32(1.05)  LDD0934  [6]
 LDCM0337  AC72 HEK-293T C32(1.07)  LDD0935  [6]
 LDCM0338  AC73 HEK-293T C32(1.07)  LDD0936  [6]
 LDCM0339  AC74 HEK-293T C32(1.09)  LDD0937  [6]
 LDCM0340  AC75 HEK-293T C32(1.06)  LDD0938  [6]
 LDCM0341  AC76 HEK-293T C32(1.03)  LDD0939  [6]
 LDCM0342  AC77 HEK-293T C32(1.20)  LDD0940  [6]
 LDCM0343  AC78 HEK-293T C32(1.01)  LDD0941  [6]
 LDCM0344  AC79 HEK-293T C32(1.15)  LDD0942  [6]
 LDCM0345  AC8 HEK-293T C32(1.54)  LDD0943  [6]
 LDCM0346  AC80 HEK-293T C32(1.19)  LDD0944  [6]
 LDCM0347  AC81 HEK-293T C32(1.29)  LDD0945  [6]
 LDCM0348  AC82 HEK-293T C32(1.59)  LDD0946  [6]
 LDCM0349  AC83 HEK-293T C32(0.97)  LDD0947  [6]
 LDCM0350  AC84 HEK-293T C32(1.35)  LDD0948  [6]
 LDCM0351  AC85 HEK-293T C32(1.25)  LDD0949  [6]
 LDCM0352  AC86 HEK-293T C32(1.05)  LDD0950  [6]
 LDCM0353  AC87 HEK-293T C32(1.22)  LDD0951  [6]
 LDCM0354  AC88 HEK-293T C32(1.07)  LDD0952  [6]
 LDCM0355  AC89 HEK-293T C32(1.52)  LDD0953  [6]
 LDCM0357  AC90 HEK-293T C32(1.46)  LDD0955  [6]
 LDCM0358  AC91 HEK-293T C32(1.43)  LDD0956  [6]
 LDCM0359  AC92 HEK-293T C32(1.24)  LDD0957  [6]
 LDCM0360  AC93 HEK-293T C32(1.44)  LDD0958  [6]
 LDCM0361  AC94 HEK-293T C32(1.75)  LDD0959  [6]
 LDCM0362  AC95 HEK-293T C32(1.17)  LDD0960  [6]
 LDCM0363  AC96 HEK-293T C32(1.09)  LDD0961  [6]
 LDCM0364  AC97 HEK-293T C32(2.34)  LDD0962  [6]
 LDCM0365  AC98 HEK-293T C32(1.41)  LDD0963  [6]
 LDCM0366  AC99 HEK-293T C32(1.30)  LDD0964  [6]
 LDCM0248  AKOS034007472 HEK-293T C32(1.14)  LDD0846  [6]
 LDCM0356  AKOS034007680 HEK-293T C32(1.27)  LDD0954  [6]
 LDCM0275  AKOS034007705 HEK-293T C32(1.41)  LDD0873  [6]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [3]
 LDCM0367  CL1 HEK-293T C32(2.06)  LDD0965  [6]
 LDCM0368  CL10 HEK-293T C32(3.59)  LDD0966  [6]
 LDCM0369  CL100 HEK-293T C32(1.20)  LDD0967  [6]
 LDCM0370  CL101 HEK-293T C32(2.14)  LDD0968  [6]
 LDCM0371  CL102 HEK-293T C32(2.17)  LDD0969  [6]
 LDCM0372  CL103 HEK-293T C32(1.58)  LDD0970  [6]
 LDCM0373  CL104 HEK-293T C32(1.52)  LDD0971  [6]
 LDCM0374  CL105 HEK-293T C32(1.31)  LDD0972  [6]
 LDCM0375  CL106 HEK-293T C32(1.23)  LDD0973  [6]
 LDCM0376  CL107 HEK-293T C32(1.28)  LDD0974  [6]
 LDCM0377  CL108 HEK-293T C32(1.26)  LDD0975  [6]
 LDCM0378  CL109 HEK-293T C32(1.60)  LDD0976  [6]
 LDCM0379  CL11 HEK-293T C32(2.22)  LDD0977  [6]
 LDCM0380  CL110 HEK-293T C32(1.67)  LDD0978  [6]
 LDCM0381  CL111 HEK-293T C32(1.70)  LDD0979  [6]
 LDCM0382  CL112 HEK-293T C32(1.43)  LDD0980  [6]
 LDCM0383  CL113 HEK-293T C32(1.18)  LDD0981  [6]
 LDCM0384  CL114 HEK-293T C32(2.15)  LDD0982  [6]
 LDCM0385  CL115 HEK-293T C32(1.61)  LDD0983  [6]
 LDCM0386  CL116 HEK-293T C32(1.31)  LDD0984  [6]
 LDCM0387  CL117 HEK-293T C32(1.13)  LDD0985  [6]
 LDCM0388  CL118 HEK-293T C32(1.47)  LDD0986  [6]
 LDCM0389  CL119 HEK-293T C32(1.40)  LDD0987  [6]
 LDCM0390  CL12 HEK-293T C32(1.36)  LDD0988  [6]
 LDCM0391  CL120 HEK-293T C32(1.07)  LDD0989  [6]
 LDCM0392  CL121 HEK-293T C32(1.67)  LDD0990  [6]
 LDCM0393  CL122 HEK-293T C32(1.15)  LDD0991  [6]
 LDCM0394  CL123 HEK-293T C32(1.53)  LDD0992  [6]
 LDCM0395  CL124 HEK-293T C32(1.49)  LDD0993  [6]
 LDCM0396  CL125 HEK-293T C32(1.11)  LDD0994  [6]
 LDCM0397  CL126 HEK-293T C32(1.30)  LDD0995  [6]
 LDCM0398  CL127 HEK-293T C32(1.00)  LDD0996  [6]
 LDCM0399  CL128 HEK-293T C32(1.12)  LDD0997  [6]
 LDCM0400  CL13 HEK-293T C32(1.02)  LDD0998  [6]
 LDCM0401  CL14 HEK-293T C32(1.66)  LDD0999  [6]
 LDCM0402  CL15 HEK-293T C32(2.43)  LDD1000  [6]
 LDCM0403  CL16 HEK-293T C32(1.61)  LDD1001  [6]
 LDCM0404  CL17 HEK-293T C32(1.52)  LDD1002  [6]
 LDCM0405  CL18 HEK-293T C32(1.39)  LDD1003  [6]
 LDCM0406  CL19 HEK-293T C32(0.96)  LDD1004  [6]
 LDCM0407  CL2 HEK-293T C32(1.25)  LDD1005  [6]
 LDCM0408  CL20 HEK-293T C32(1.09)  LDD1006  [6]
 LDCM0409  CL21 HEK-293T C32(1.66)  LDD1007  [6]
 LDCM0410  CL22 HEK-293T C32(1.18)  LDD1008  [6]
 LDCM0411  CL23 HEK-293T C32(1.40)  LDD1009  [6]
 LDCM0412  CL24 HEK-293T C32(1.32)  LDD1010  [6]
 LDCM0413  CL25 HEK-293T C32(1.28)  LDD1011  [6]
 LDCM0414  CL26 HEK-293T C32(1.05)  LDD1012  [6]
 LDCM0415  CL27 HEK-293T C32(1.00)  LDD1013  [6]
 LDCM0416  CL28 HEK-293T C32(0.86)  LDD1014  [6]
 LDCM0417  CL29 HEK-293T C32(1.05)  LDD1015  [6]
 LDCM0418  CL3 HEK-293T C32(1.48)  LDD1016  [6]
 LDCM0419  CL30 HEK-293T C32(1.70)  LDD1017  [6]
 LDCM0420  CL31 HEK-293T C32(1.57)  LDD1018  [6]
 LDCM0421  CL32 HEK-293T C32(1.42)  LDD1019  [6]
 LDCM0422  CL33 HEK-293T C32(2.55)  LDD1020  [6]
 LDCM0423  CL34 HEK-293T C32(1.16)  LDD1021  [6]
 LDCM0424  CL35 HEK-293T C32(1.54)  LDD1022  [6]
 LDCM0425  CL36 HEK-293T C32(1.22)  LDD1023  [6]
 LDCM0426  CL37 HEK-293T C32(1.36)  LDD1024  [6]
 LDCM0428  CL39 HEK-293T C32(2.25)  LDD1026  [6]
 LDCM0429  CL4 HEK-293T C32(1.28)  LDD1027  [6]
 LDCM0430  CL40 HEK-293T C32(1.73)  LDD1028  [6]
 LDCM0431  CL41 HEK-293T C32(2.32)  LDD1029  [6]
 LDCM0432  CL42 HEK-293T C32(1.60)  LDD1030  [6]
 LDCM0433  CL43 HEK-293T C32(1.56)  LDD1031  [6]
 LDCM0434  CL44 HEK-293T C32(1.24)  LDD1032  [6]
 LDCM0435  CL45 HEK-293T C32(2.00)  LDD1033  [6]
 LDCM0436  CL46 HEK-293T C32(2.30)  LDD1034  [6]
 LDCM0437  CL47 HEK-293T C32(1.48)  LDD1035  [6]
 LDCM0438  CL48 HEK-293T C32(1.65)  LDD1036  [6]
 LDCM0439  CL49 HEK-293T C32(1.47)  LDD1037  [6]
 LDCM0440  CL5 HEK-293T C32(1.30)  LDD1038  [6]
 LDCM0441  CL50 HEK-293T C32(1.90)  LDD1039  [6]
 LDCM0442  CL51 HEK-293T C32(1.49)  LDD1040  [6]
 LDCM0443  CL52 HEK-293T C32(0.82)  LDD1041  [6]
 LDCM0444  CL53 HEK-293T C32(1.04)  LDD1042  [6]
 LDCM0445  CL54 HEK-293T C32(1.46)  LDD1043  [6]
 LDCM0446  CL55 HEK-293T C32(1.58)  LDD1044  [6]
 LDCM0447  CL56 HEK-293T C32(1.18)  LDD1045  [6]
 LDCM0448  CL57 HEK-293T C32(1.32)  LDD1046  [6]
 LDCM0449  CL58 HEK-293T C32(1.07)  LDD1047  [6]
 LDCM0450  CL59 HEK-293T C32(1.73)  LDD1048  [6]
 LDCM0451  CL6 HEK-293T C32(1.27)  LDD1049  [6]
 LDCM0452  CL60 HEK-293T C32(2.16)  LDD1050  [6]
 LDCM0453  CL61 HEK-293T C32(1.44)  LDD1051  [6]
 LDCM0454  CL62 HEK-293T C32(1.08)  LDD1052  [6]
 LDCM0455  CL63 HEK-293T C32(1.58)  LDD1053  [6]
 LDCM0456  CL64 HEK-293T C32(1.34)  LDD1054  [6]
 LDCM0457  CL65 HEK-293T C32(0.97)  LDD1055  [6]
 LDCM0458  CL66 HEK-293T C32(0.83)  LDD1056  [6]
 LDCM0459  CL67 HEK-293T C32(0.85)  LDD1057  [6]
 LDCM0460  CL68 HEK-293T C32(0.85)  LDD1058  [6]
 LDCM0461  CL69 HEK-293T C32(0.92)  LDD1059  [6]
 LDCM0462  CL7 HEK-293T C32(1.98)  LDD1060  [6]
 LDCM0463  CL70 HEK-293T C32(0.89)  LDD1061  [6]
 LDCM0464  CL71 HEK-293T C32(1.27)  LDD1062  [6]
 LDCM0465  CL72 HEK-293T C32(1.06)  LDD1063  [6]
 LDCM0466  CL73 HEK-293T C32(0.94)  LDD1064  [6]
 LDCM0467  CL74 HEK-293T C32(1.66)  LDD1065  [6]
 LDCM0469  CL76 HEK-293T C32(0.78)  LDD1067  [6]
 LDCM0470  CL77 HEK-293T C32(1.53)  LDD1068  [6]
 LDCM0471  CL78 HEK-293T C32(0.62)  LDD1069  [6]
 LDCM0472  CL79 HEK-293T C32(1.26)  LDD1070  [6]
 LDCM0473  CL8 HEK-293T C32(1.88)  LDD1071  [6]
 LDCM0474  CL80 HEK-293T C32(0.66)  LDD1072  [6]
 LDCM0475  CL81 HEK-293T C32(1.04)  LDD1073  [6]
 LDCM0476  CL82 HEK-293T C32(1.55)  LDD1074  [6]
 LDCM0477  CL83 HEK-293T C32(1.86)  LDD1075  [6]
 LDCM0478  CL84 HEK-293T C32(0.90)  LDD1076  [6]
 LDCM0479  CL85 HEK-293T C32(0.82)  LDD1077  [6]
 LDCM0480  CL86 HEK-293T C32(0.82)  LDD1078  [6]
 LDCM0481  CL87 HEK-293T C32(1.21)  LDD1079  [6]
 LDCM0482  CL88 HEK-293T C32(1.08)  LDD1080  [6]
 LDCM0483  CL89 HEK-293T C32(0.99)  LDD1081  [6]
 LDCM0484  CL9 HEK-293T C32(1.98)  LDD1082  [6]
 LDCM0485  CL90 HEK-293T C32(1.59)  LDD1083  [6]
 LDCM0486  CL91 HEK-293T C32(1.07)  LDD1084  [6]
 LDCM0487  CL92 HEK-293T C32(1.31)  LDD1085  [6]
 LDCM0488  CL93 HEK-293T C32(0.83)  LDD1086  [6]
 LDCM0489  CL94 HEK-293T C32(1.15)  LDD1087  [6]
 LDCM0490  CL95 HEK-293T C32(1.85)  LDD1088  [6]
 LDCM0491  CL96 HEK-293T C32(1.44)  LDD1089  [6]
 LDCM0492  CL97 HEK-293T C32(1.10)  LDD1090  [6]
 LDCM0493  CL98 HEK-293T C32(0.86)  LDD1091  [6]
 LDCM0494  CL99 HEK-293T C32(0.70)  LDD1092  [6]
 LDCM0495  E2913 HEK-293T C32(0.99)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C32(1.50)  LDD1066  [6]
 LDCM0427  Fragment51 HEK-293T C32(1.12)  LDD1025  [6]
 LDCM0022  KB02 HEK-293T C32(1.04); C17(0.93); C504(1.05)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C32(0.78); C17(1.03); C504(1.00)  LDD1497  [7]
 LDCM0024  KB05 SKMEL24 C32(1.06)  LDD3323  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402