Details of the Target

General Information of Target

Target ID LDTP10942
Target Name Monoglyceride lipase (MGLL)
Gene Name MGLL
Gene ID 11343
Synonyms
Monoglyceride lipase; MGL; EC 3.1.1.23; HU-K5; Lysophospholipase homolog; Lysophospholipase-like; Monoacylglycerol lipase; MAGL
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
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Sequence
MPRSFLVKSKKAHSYHQPRSPGPDYSLRLENVPAPSRADSTSNAGGAKAEPRDRLSPESQ
LTEAPDRASASPDSCEGSVCERSSEFEDFWRPPSPSASPASEKSMCPSLDEAQPFPLPFK
PYSWSGLAGSDLRHLVQSYRPCGALERGAGLGLFCEPAPEPGHPAALYGPKRAAGGAGAG
APGSCSAGAGATAGPGLGLYGDFGSAAAGLYERPTAAAGLLYPERGHGLHADKGAGVKVE
SELLCTRLLLGGGSYKCIKCSKVFSTPHGLEVHVRRSHSGTRPFACEMCGKTFGHAVSLE
QHKAVHSQERSFDCKICGKSFKRSSTLSTHLLIHSDTRPYPCQYCGKRFHQKSDMKKHTF
IHTGEKPHKCQVCGKAFSQSSNLITHSRKHTGFKPFGCDLCGKGFQRKVDLRRHRETQHG
LK
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
AB hydrolase superfamily, Monoacylglycerol lipase family
Subcellular location
Cytoplasm, cytosol
Function
Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain. Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth.
TTD ID
T18664
Uniprot ID
Q99685
DrugMap ID
TTZ963I
Ensemble ID
ENST00000398104.6
HGNC ID
HGNC:17038
ChEMBL ID
CHEMBL4191

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C201(1.01)  LDD0078  [1]
NAIA_4
 Probe Info  		C201(0.00); C208(0.00)  LDD2226  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0149  [3]
IPM
 Probe Info  		N.A.  LDD0147  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [4]
NAIA_5
 Probe Info  		C242(0.00); C32(0.00)  LDD2223  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C208(1.69); C201(0.18)  LDD1093  [1]
 LDCM0215  AC10 PaTu 8988t C208(1.81); C201(1.24)  LDD1094  [1]
 LDCM0216  AC100 PaTu 8988t C208(1.16); C201(1.22)  LDD1095  [1]
 LDCM0217  AC101 PaTu 8988t C208(1.30); C201(1.13)  LDD1096  [1]
 LDCM0218  AC102 PaTu 8988t C208(1.38); C201(0.96)  LDD1097  [1]
 LDCM0219  AC103 PaTu 8988t C208(1.12); C201(1.08)  LDD1098  [1]
 LDCM0220  AC104 PaTu 8988t C208(1.12); C201(0.93)  LDD1099  [1]
 LDCM0221  AC105 PaTu 8988t C208(1.11); C201(1.04)  LDD1100  [1]
 LDCM0222  AC106 PaTu 8988t C208(1.18); C201(1.12)  LDD1101  [1]
 LDCM0223  AC107 PaTu 8988t C208(0.94); C201(0.95)  LDD1102  [1]
 LDCM0224  AC108 PaTu 8988t C208(1.37); C201(1.14)  LDD1103  [1]
 LDCM0225  AC109 PaTu 8988t C208(1.27); C201(1.14)  LDD1104  [1]
 LDCM0226  AC11 PaTu 8988t C208(1.74); C201(1.28)  LDD1105  [1]
 LDCM0227  AC110 PaTu 8988t C208(1.92); C201(1.08)  LDD1106  [1]
 LDCM0228  AC111 PaTu 8988t C208(1.32); C201(1.24)  LDD1107  [1]
 LDCM0229  AC112 PaTu 8988t C208(1.53); C201(1.02)  LDD1108  [1]
 LDCM0230  AC113 PaTu 8988t C208(0.75); C201(0.80)  LDD1109  [1]
 LDCM0231  AC114 PaTu 8988t C208(0.83); C201(0.86)  LDD1110  [1]
 LDCM0232  AC115 PaTu 8988t C208(0.78); C201(0.96)  LDD1111  [1]
 LDCM0233  AC116 PaTu 8988t C208(0.75); C201(0.89)  LDD1112  [1]
 LDCM0234  AC117 PaTu 8988t C208(0.66); C201(0.92)  LDD1113  [1]
 LDCM0235  AC118 PaTu 8988t C208(0.93); C201(0.89)  LDD1114  [1]
 LDCM0236  AC119 PaTu 8988t C208(0.88); C201(0.94)  LDD1115  [1]
 LDCM0237  AC12 PaTu 8988t C208(1.68); C201(1.02)  LDD1116  [1]
 LDCM0238  AC120 PaTu 8988t C208(0.78); C201(0.94)  LDD1117  [1]
 LDCM0239  AC121 PaTu 8988t C208(1.06); C201(0.97)  LDD1118  [1]
 LDCM0240  AC122 PaTu 8988t C208(0.90); C201(0.84)  LDD1119  [1]
 LDCM0241  AC123 PaTu 8988t C208(0.88); C201(0.83)  LDD1120  [1]
 LDCM0242  AC124 PaTu 8988t C208(1.10); C201(1.03)  LDD1121  [1]
 LDCM0243  AC125 PaTu 8988t C208(1.21); C201(0.94)  LDD1122  [1]
 LDCM0244  AC126 PaTu 8988t C208(0.81); C201(0.85)  LDD1123  [1]
 LDCM0245  AC127 PaTu 8988t C208(0.97); C201(0.98)  LDD1124  [1]
 LDCM0246  AC128 PaTu 8988t C208(1.47); C201(1.27)  LDD1125  [1]
 LDCM0247  AC129 PaTu 8988t C208(1.52); C201(1.14)  LDD1126  [1]
 LDCM0249  AC130 PaTu 8988t C208(1.26); C201(1.14)  LDD1128  [1]
 LDCM0250  AC131 PaTu 8988t C208(1.47); C201(1.03)  LDD1129  [1]
 LDCM0251  AC132 PaTu 8988t C208(1.24); C201(1.11)  LDD1130  [1]
 LDCM0252  AC133 PaTu 8988t C208(2.50); C201(1.15)  LDD1131  [1]
 LDCM0253  AC134 PaTu 8988t C208(2.10); C201(1.19)  LDD1132  [1]
 LDCM0254  AC135 PaTu 8988t C208(2.49); C201(1.38)  LDD1133  [1]
 LDCM0255  AC136 PaTu 8988t C208(1.82); C201(1.36)  LDD1134  [1]
 LDCM0256  AC137 PaTu 8988t C208(2.55); C201(1.39)  LDD1135  [1]
 LDCM0257  AC138 PaTu 8988t C208(1.62); C201(1.14)  LDD1136  [1]
 LDCM0258  AC139 PaTu 8988t C208(1.58); C201(1.27)  LDD1137  [1]
 LDCM0259  AC14 PaTu 8988t C208(1.35); C201(0.91)  LDD1138  [1]
 LDCM0260  AC140 PaTu 8988t C208(1.46); C201(1.27)  LDD1139  [1]
 LDCM0261  AC141 PaTu 8988t C208(1.35); C201(1.20)  LDD1140  [1]
 LDCM0262  AC142 PaTu 8988t C208(1.76); C201(1.23)  LDD1141  [1]
 LDCM0263  AC143 PaTu 8988t C208(0.95); C201(0.97)  LDD1142  [1]
 LDCM0264  AC144 PaTu 8988t C208(1.01); C201(1.23)  LDD1143  [1]
 LDCM0265  AC145 PaTu 8988t C208(0.96); C201(1.02)  LDD1144  [1]
 LDCM0266  AC146 PaTu 8988t C208(0.98); C201(0.97)  LDD1145  [1]
 LDCM0267  AC147 PaTu 8988t C208(0.96); C201(0.88)  LDD1146  [1]
 LDCM0268  AC148 PaTu 8988t C208(1.24); C201(1.21)  LDD1147  [1]
 LDCM0269  AC149 PaTu 8988t C208(1.29); C201(1.37)  LDD1148  [1]
 LDCM0270  AC15 PaTu 8988t C208(1.43); C201(1.15)  LDD1149  [1]
 LDCM0271  AC150 PaTu 8988t C208(1.19); C201(1.41)  LDD1150  [1]
 LDCM0272  AC151 PaTu 8988t C208(1.48); C201(1.46)  LDD1151  [1]
 LDCM0273  AC152 PaTu 8988t C208(1.13); C201(1.31)  LDD1152  [1]
 LDCM0274  AC153 PaTu 8988t C208(1.31); C201(1.30)  LDD1153  [1]
 LDCM0621  AC154 PaTu 8988t C208(1.43); C201(1.52)  LDD2166  [1]
 LDCM0622  AC155 PaTu 8988t C208(1.28); C201(1.50)  LDD2167  [1]
 LDCM0623  AC156 PaTu 8988t C208(1.28); C201(1.40)  LDD2168  [1]
 LDCM0624  AC157 PaTu 8988t C208(1.17); C201(1.23)  LDD2169  [1]
 LDCM0276  AC17 PaTu 8988t C208(1.22); C201(1.13)  LDD1155  [1]
 LDCM0277  AC18 PaTu 8988t C208(1.49); C201(1.27)  LDD1156  [1]
 LDCM0278  AC19 PaTu 8988t C208(1.26); C201(1.09)  LDD1157  [1]
 LDCM0279  AC2 PaTu 8988t C208(1.11); C201(0.16)  LDD1158  [1]
 LDCM0280  AC20 PaTu 8988t C208(1.31); C201(1.30)  LDD1159  [1]
 LDCM0281  AC21 PaTu 8988t C208(1.45); C201(1.27)  LDD1160  [1]
 LDCM0282  AC22 PaTu 8988t C208(1.61); C201(1.50)  LDD1161  [1]
 LDCM0283  AC23 PaTu 8988t C208(1.64); C201(1.29)  LDD1162  [1]
 LDCM0284  AC24 PaTu 8988t C208(1.62); C201(1.11)  LDD1163  [1]
 LDCM0285  AC25 PaTu 8988t C208(0.93)  LDD1164  [1]
 LDCM0286  AC26 PaTu 8988t C208(1.11)  LDD1165  [1]
 LDCM0287  AC27 PaTu 8988t C208(1.14)  LDD1166  [1]
 LDCM0288  AC28 PaTu 8988t C208(1.32)  LDD1167  [1]
 LDCM0289  AC29 PaTu 8988t C208(1.04)  LDD1168  [1]
 LDCM0290  AC3 PaTu 8988t C208(1.20); C201(0.17)  LDD1169  [1]
 LDCM0291  AC30 PaTu 8988t C208(0.89)  LDD1170  [1]
 LDCM0292  AC31 PaTu 8988t C208(1.05)  LDD1171  [1]
 LDCM0293  AC32 PaTu 8988t C208(1.03)  LDD1172  [1]
 LDCM0294  AC33 PaTu 8988t C208(1.29)  LDD1173  [1]
 LDCM0295  AC34 PaTu 8988t C208(1.25)  LDD1174  [1]
 LDCM0296  AC35 PaTu 8988t C201(1.19)  LDD1175  [1]
 LDCM0297  AC36 PaTu 8988t C201(1.30)  LDD1176  [1]
 LDCM0298  AC37 PaTu 8988t C201(1.80)  LDD1177  [1]
 LDCM0299  AC38 PaTu 8988t C201(1.57)  LDD1178  [1]
 LDCM0300  AC39 PaTu 8988t C201(1.68)  LDD1179  [1]
 LDCM0301  AC4 PaTu 8988t C208(1.01); C201(0.17)  LDD1180  [1]
 LDCM0302  AC40 PaTu 8988t C201(1.49)  LDD1181  [1]
 LDCM0303  AC41 PaTu 8988t C201(1.10)  LDD1182  [1]
 LDCM0304  AC42 PaTu 8988t C201(1.38)  LDD1183  [1]
 LDCM0305  AC43 PaTu 8988t C201(1.40)  LDD1184  [1]
 LDCM0306  AC44 PaTu 8988t C201(1.73)  LDD1185  [1]
 LDCM0307  AC45 PaTu 8988t C201(1.47)  LDD1186  [1]
 LDCM0308  AC46 PaTu 8988t C208(1.11); C201(0.99)  LDD1187  [1]
 LDCM0309  AC47 PaTu 8988t C208(1.08); C201(1.03)  LDD1188  [1]
 LDCM0310  AC48 PaTu 8988t C208(1.24); C201(1.02)  LDD1189  [1]
 LDCM0311  AC49 PaTu 8988t C208(1.51); C201(1.32)  LDD1190  [1]
 LDCM0312  AC5 PaTu 8988t C208(1.47); C201(0.18)  LDD1191  [1]
 LDCM0313  AC50 PaTu 8988t C208(1.60); C201(1.37)  LDD1192  [1]
 LDCM0314  AC51 PaTu 8988t C208(1.96); C201(0.30)  LDD1193  [1]
 LDCM0315  AC52 PaTu 8988t C208(1.53); C201(1.08)  LDD1194  [1]
 LDCM0316  AC53 PaTu 8988t C208(1.81); C201(1.66)  LDD1195  [1]
 LDCM0317  AC54 PaTu 8988t C208(2.06); C201(1.37)  LDD1196  [1]
 LDCM0318  AC55 PaTu 8988t C208(1.26); C201(1.08)  LDD1197  [1]
 LDCM0319  AC56 PaTu 8988t C208(1.81); C201(1.05)  LDD1198  [1]
 LDCM0320  AC57 PaTu 8988t C208(1.36); C201(1.32)  LDD1199  [1]
 LDCM0321  AC58 PaTu 8988t C208(1.00); C201(1.24)  LDD1200  [1]
 LDCM0322  AC59 PaTu 8988t C208(1.03); C201(1.33)  LDD1201  [1]
 LDCM0323  AC6 PaTu 8988t C208(1.18); C201(1.05)  LDD1202  [1]
 LDCM0324  AC60 PaTu 8988t C208(1.31); C201(1.37)  LDD1203  [1]
 LDCM0325  AC61 PaTu 8988t C208(1.17); C201(1.19)  LDD1204  [1]
 LDCM0326  AC62 PaTu 8988t C208(1.17); C201(1.76)  LDD1205  [1]
 LDCM0327  AC63 PaTu 8988t C208(1.07); C201(1.35)  LDD1206  [1]
 LDCM0328  AC64 PaTu 8988t C208(1.15); C201(1.22)  LDD1207  [1]
 LDCM0329  AC65 PaTu 8988t C208(1.08); C201(1.12)  LDD1208  [1]
 LDCM0330  AC66 PaTu 8988t C208(1.17); C201(1.22)  LDD1209  [1]
 LDCM0331  AC67 PaTu 8988t C208(1.11); C201(1.23)  LDD1210  [1]
 LDCM0332  AC68 PaTu 8988t C208(0.88); C201(1.00)  LDD1211  [1]
 LDCM0333  AC69 PaTu 8988t C208(0.92); C201(1.09)  LDD1212  [1]
 LDCM0334  AC7 PaTu 8988t C208(0.86); C201(1.00)  LDD1213  [1]
 LDCM0335  AC70 PaTu 8988t C208(1.00); C201(0.88)  LDD1214  [1]
 LDCM0336  AC71 PaTu 8988t C208(0.90); C201(0.93)  LDD1215  [1]
 LDCM0337  AC72 PaTu 8988t C208(0.79); C201(0.85)  LDD1216  [1]
 LDCM0338  AC73 PaTu 8988t C208(0.86); C201(0.83)  LDD1217  [1]
 LDCM0339  AC74 PaTu 8988t C208(0.90); C201(0.81)  LDD1218  [1]
 LDCM0340  AC75 PaTu 8988t C208(0.98); C201(1.05)  LDD1219  [1]
 LDCM0341  AC76 PaTu 8988t C208(0.93); C201(0.98)  LDD1220  [1]
 LDCM0342  AC77 PaTu 8988t C208(0.93); C201(0.89)  LDD1221  [1]
 LDCM0343  AC78 PaTu 8988t C208(1.00); C201(0.80)  LDD1222  [1]
 LDCM0344  AC79 PaTu 8988t C208(1.05); C201(0.93)  LDD1223  [1]
 LDCM0345  AC8 PaTu 8988t C208(1.04); C201(0.87)  LDD1224  [1]
 LDCM0346  AC80 PaTu 8988t C208(0.95); C201(0.86)  LDD1225  [1]
 LDCM0347  AC81 PaTu 8988t C208(1.04); C201(0.87)  LDD1226  [1]
 LDCM0348  AC82 PaTu 8988t C208(0.91); C201(0.97)  LDD1227  [1]
 LDCM0349  AC83 PaTu 8988t C208(0.97); C201(0.92)  LDD1228  [1]
 LDCM0350  AC84 PaTu 8988t C208(0.96); C201(1.14)  LDD1229  [1]
 LDCM0351  AC85 PaTu 8988t C208(0.91); C201(1.08)  LDD1230  [1]
 LDCM0352  AC86 PaTu 8988t C208(0.98); C201(1.19)  LDD1231  [1]
 LDCM0353  AC87 PaTu 8988t C208(0.93); C201(1.08)  LDD1232  [1]
 LDCM0354  AC88 PaTu 8988t C208(0.93); C201(0.98)  LDD1233  [1]
 LDCM0355  AC89 PaTu 8988t C208(0.88); C201(0.86)  LDD1234  [1]
 LDCM0357  AC90 PaTu 8988t C208(1.10); C201(1.10)  LDD1236  [1]
 LDCM0358  AC91 PaTu 8988t C208(1.06); C201(1.04)  LDD1237  [1]
 LDCM0359  AC92 PaTu 8988t C208(0.95); C201(0.95)  LDD1238  [1]
 LDCM0360  AC93 PaTu 8988t C208(0.82); C201(0.92)  LDD1239  [1]
 LDCM0361  AC94 PaTu 8988t C208(0.83); C201(0.97)  LDD1240  [1]
 LDCM0362  AC95 PaTu 8988t C208(0.98); C201(1.01)  LDD1241  [1]
 LDCM0363  AC96 PaTu 8988t C208(0.91); C201(0.99)  LDD1242  [1]
 LDCM0364  AC97 PaTu 8988t C208(0.95); C201(0.88)  LDD1243  [1]
 LDCM0365  AC98 PaTu 8988t C208(1.30); C201(1.06)  LDD1244  [1]
 LDCM0366  AC99 PaTu 8988t C208(1.00); C201(1.00)  LDD1245  [1]
 LDCM0248  AKOS034007472 PaTu 8988t C208(1.68); C201(0.89)  LDD1127  [1]
 LDCM0356  AKOS034007680 PaTu 8988t C208(1.50); C201(1.51)  LDD1235  [1]
 LDCM0275  AKOS034007705 PaTu 8988t C208(1.54); C201(1.31)  LDD1154  [1]
 LDCM0020  ARS-1620 HCC44 C201(1.01)  LDD0078  [1]
 LDCM0632  CL-Sc Hep-G2 C208(0.45)  LDD2227  [2]
 LDCM0367  CL1 PaTu 8988t C208(0.90); C201(0.95)  LDD1246  [1]
 LDCM0368  CL10 PaTu 8988t C208(1.48); C201(1.25)  LDD1247  [1]
 LDCM0369  CL100 PaTu 8988t C208(1.17); C201(0.12)  LDD1248  [1]
 LDCM0370  CL101 PaTu 8988t C208(1.17); C201(0.98)  LDD1249  [1]
 LDCM0371  CL102 PaTu 8988t C208(1.22); C201(1.19)  LDD1250  [1]
 LDCM0372  CL103 PaTu 8988t C208(2.02); C201(1.15)  LDD1251  [1]
 LDCM0373  CL104 PaTu 8988t C208(1.32); C201(1.18)  LDD1252  [1]
 LDCM0374  CL105 PaTu 8988t C208(1.09); C201(1.04)  LDD1253  [1]
 LDCM0375  CL106 PaTu 8988t C208(1.15); C201(0.98)  LDD1254  [1]
 LDCM0376  CL107 PaTu 8988t C208(1.15); C201(1.03)  LDD1255  [1]
 LDCM0377  CL108 PaTu 8988t C208(1.13); C201(1.14)  LDD1256  [1]
 LDCM0378  CL109 PaTu 8988t C208(1.32); C201(1.22)  LDD1257  [1]
 LDCM0379  CL11 PaTu 8988t C208(0.99); C201(1.06)  LDD1258  [1]
 LDCM0380  CL110 PaTu 8988t C208(1.53); C201(1.31)  LDD1259  [1]
 LDCM0381  CL111 PaTu 8988t C208(2.12); C201(1.61)  LDD1260  [1]
 LDCM0382  CL112 PaTu 8988t C208(0.97)  LDD1261  [1]
 LDCM0383  CL113 PaTu 8988t C208(0.99)  LDD1262  [1]
 LDCM0384  CL114 PaTu 8988t C208(0.98)  LDD1263  [1]
 LDCM0385  CL115 PaTu 8988t C208(1.00)  LDD1264  [1]
 LDCM0386  CL116 PaTu 8988t C208(1.13)  LDD1265  [1]
 LDCM0387  CL117 PaTu 8988t C201(1.17)  LDD1266  [1]
 LDCM0388  CL118 PaTu 8988t C201(1.28)  LDD1267  [1]
 LDCM0389  CL119 PaTu 8988t C201(1.52)  LDD1268  [1]
 LDCM0390  CL12 PaTu 8988t C208(1.21); C201(1.10)  LDD1269  [1]
 LDCM0391  CL120 PaTu 8988t C201(1.51)  LDD1270  [1]
 LDCM0392  CL121 PaTu 8988t C208(1.10); C201(1.03)  LDD1271  [1]
 LDCM0393  CL122 PaTu 8988t C208(1.56); C201(1.04)  LDD1272  [1]
 LDCM0394  CL123 PaTu 8988t C208(1.44); C201(1.18)  LDD1273  [1]
 LDCM0395  CL124 PaTu 8988t C208(1.55); C201(1.41)  LDD1274  [1]
 LDCM0396  CL125 PaTu 8988t C208(1.04); C201(1.14)  LDD1275  [1]
 LDCM0397  CL126 PaTu 8988t C208(1.02); C201(1.09)  LDD1276  [1]
 LDCM0398  CL127 PaTu 8988t C208(1.02); C201(1.04)  LDD1277  [1]
 LDCM0399  CL128 PaTu 8988t C208(1.17); C201(1.24)  LDD1278  [1]
 LDCM0400  CL13 PaTu 8988t C208(2.42); C201(1.41)  LDD1279  [1]
 LDCM0401  CL14 PaTu 8988t C208(2.59); C201(1.33)  LDD1280  [1]
 LDCM0402  CL15 PaTu 8988t C208(1.46); C201(0.96)  LDD1281  [1]
 LDCM0403  CL16 PaTu 8988t C208(1.57); C201(1.17)  LDD1282  [1]
 LDCM0404  CL17 PaTu 8988t C208(1.77); C201(0.97)  LDD1283  [1]
 LDCM0405  CL18 PaTu 8988t C208(1.70); C201(1.14)  LDD1284  [1]
 LDCM0406  CL19 PaTu 8988t C208(2.34); C201(1.20)  LDD1285  [1]
 LDCM0407  CL2 PaTu 8988t C208(1.26); C201(0.99)  LDD1286  [1]
 LDCM0408  CL20 PaTu 8988t C208(2.75); C201(1.16)  LDD1287  [1]
 LDCM0409  CL21 PaTu 8988t C208(3.19); C201(1.14)  LDD1288  [1]
 LDCM0410  CL22 PaTu 8988t C208(2.95); C201(1.24)  LDD1289  [1]
 LDCM0411  CL23 PaTu 8988t C208(3.49); C201(1.11)  LDD1290  [1]
 LDCM0412  CL24 PaTu 8988t C208(1.62); C201(1.22)  LDD1291  [1]
 LDCM0413  CL25 PaTu 8988t C208(1.77); C201(1.09)  LDD1292  [1]
 LDCM0414  CL26 PaTu 8988t C208(2.75); C201(1.09)  LDD1293  [1]
 LDCM0415  CL27 PaTu 8988t C208(1.67); C201(1.43)  LDD1294  [1]
 LDCM0416  CL28 PaTu 8988t C208(3.88); C201(1.66)  LDD1295  [1]
 LDCM0417  CL29 PaTu 8988t C208(4.33); C201(1.04)  LDD1296  [1]
 LDCM0418  CL3 PaTu 8988t C208(1.20); C201(1.06)  LDD1297  [1]
 LDCM0419  CL30 PaTu 8988t C208(2.28); C201(1.12)  LDD1298  [1]
 LDCM0420  CL31 PaTu 8988t C208(1.23); C201(1.20)  LDD1299  [1]
 LDCM0421  CL32 PaTu 8988t C208(1.34); C201(1.16)  LDD1300  [1]
 LDCM0422  CL33 PaTu 8988t C208(1.43); C201(1.06)  LDD1301  [1]
 LDCM0423  CL34 PaTu 8988t C208(1.42); C201(1.16)  LDD1302  [1]
 LDCM0424  CL35 PaTu 8988t C201(1.36); C208(1.38)  LDD1303  [1]
 LDCM0425  CL36 PaTu 8988t C208(1.67); C201(0.71)  LDD1304  [1]
 LDCM0426  CL37 PaTu 8988t C208(1.84); C201(1.44)  LDD1305  [1]
 LDCM0428  CL39 PaTu 8988t C208(1.48); C201(1.19)  LDD1307  [1]
 LDCM0429  CL4 PaTu 8988t C208(1.33); C201(0.94)  LDD1308  [1]
 LDCM0430  CL40 PaTu 8988t C208(1.34); C201(1.20)  LDD1309  [1]
 LDCM0431  CL41 PaTu 8988t C208(1.48); C201(1.16)  LDD1310  [1]
 LDCM0432  CL42 PaTu 8988t C208(4.54); C201(1.33)  LDD1311  [1]
 LDCM0433  CL43 PaTu 8988t C208(2.86); C201(1.59)  LDD1312  [1]
 LDCM0434  CL44 PaTu 8988t C208(1.97); C201(1.48)  LDD1313  [1]
 LDCM0435  CL45 PaTu 8988t C208(1.86); C201(1.20)  LDD1314  [1]
 LDCM0436  CL46 PaTu 8988t C208(1.17); C201(1.14)  LDD1315  [1]
 LDCM0437  CL47 PaTu 8988t C208(1.09); C201(1.10)  LDD1316  [1]
 LDCM0438  CL48 PaTu 8988t C208(1.11); C201(1.08)  LDD1317  [1]
 LDCM0439  CL49 PaTu 8988t C208(1.10); C201(1.16)  LDD1318  [1]
 LDCM0440  CL5 PaTu 8988t C208(2.12); C201(1.19)  LDD1319  [1]
 LDCM0441  CL50 PaTu 8988t C208(1.10); C201(1.31)  LDD1320  [1]
 LDCM0442  CL51 PaTu 8988t C208(1.04); C201(1.23)  LDD1321  [1]
 LDCM0443  CL52 PaTu 8988t C208(1.18); C201(1.26)  LDD1322  [1]
 LDCM0444  CL53 PaTu 8988t C208(1.29); C201(1.33)  LDD1323  [1]
 LDCM0445  CL54 PaTu 8988t C208(1.01); C201(1.13)  LDD1324  [1]
 LDCM0446  CL55 PaTu 8988t C208(1.25); C201(1.18)  LDD1325  [1]
 LDCM0447  CL56 PaTu 8988t C208(0.63); C201(0.73)  LDD1326  [1]
 LDCM0448  CL57 PaTu 8988t C208(2.37); C201(1.51)  LDD1327  [1]
 LDCM0449  CL58 PaTu 8988t C208(1.52); C201(1.29)  LDD1328  [1]
 LDCM0450  CL59 PaTu 8988t C208(1.97); C201(1.55)  LDD1329  [1]
 LDCM0451  CL6 PaTu 8988t C208(1.36); C201(0.93)  LDD1330  [1]
 LDCM0452  CL60 PaTu 8988t C208(1.64); C201(1.41)  LDD1331  [1]
 LDCM0453  CL61 PaTu 8988t C208(1.10); C201(1.06)  LDD1332  [1]
 LDCM0454  CL62 PaTu 8988t C208(1.16); C201(1.18)  LDD1333  [1]
 LDCM0455  CL63 PaTu 8988t C208(1.00); C201(1.21)  LDD1334  [1]
 LDCM0456  CL64 PaTu 8988t C208(1.25); C201(1.33)  LDD1335  [1]
 LDCM0457  CL65 PaTu 8988t C208(1.25); C201(1.23)  LDD1336  [1]
 LDCM0458  CL66 PaTu 8988t C208(1.29); C201(1.45)  LDD1337  [1]
 LDCM0459  CL67 PaTu 8988t C208(1.37); C201(1.36)  LDD1338  [1]
 LDCM0460  CL68 PaTu 8988t C208(1.70); C201(1.45)  LDD1339  [1]
 LDCM0461  CL69 PaTu 8988t C208(2.25); C201(1.64)  LDD1340  [1]
 LDCM0462  CL7 PaTu 8988t C208(1.79); C201(1.17)  LDD1341  [1]
 LDCM0463  CL70 PaTu 8988t C208(1.13); C201(1.49)  LDD1342  [1]
 LDCM0464  CL71 PaTu 8988t C208(1.09); C201(1.07)  LDD1343  [1]
 LDCM0465  CL72 PaTu 8988t C208(0.88); C201(1.37)  LDD1344  [1]
 LDCM0466  CL73 PaTu 8988t C208(1.68); C201(1.29)  LDD1345  [1]
 LDCM0467  CL74 PaTu 8988t C208(1.10); C201(1.40)  LDD1346  [1]
 LDCM0469  CL76 PaTu 8988t C208(1.05); C201(0.96)  LDD1348  [1]
 LDCM0470  CL77 PaTu 8988t C208(1.31); C201(0.84)  LDD1349  [1]
 LDCM0471  CL78 PaTu 8988t C208(1.44); C201(1.25)  LDD1350  [1]
 LDCM0472  CL79 PaTu 8988t C208(1.33); C201(1.37)  LDD1351  [1]
 LDCM0473  CL8 PaTu 8988t C208(2.21); C201(3.55)  LDD1352  [1]
 LDCM0474  CL80 PaTu 8988t C208(1.31); C201(1.07)  LDD1353  [1]
 LDCM0475  CL81 PaTu 8988t C208(1.57); C201(1.02)  LDD1354  [1]
 LDCM0476  CL82 PaTu 8988t C208(1.27); C201(1.09)  LDD1355  [1]
 LDCM0477  CL83 PaTu 8988t C208(1.39); C201(1.16)  LDD1356  [1]
 LDCM0478  CL84 PaTu 8988t C208(1.55); C201(1.27)  LDD1357  [1]
 LDCM0479  CL85 PaTu 8988t C208(1.53); C201(1.13)  LDD1358  [1]
 LDCM0480  CL86 PaTu 8988t C208(1.64); C201(1.13)  LDD1359  [1]
 LDCM0481  CL87 PaTu 8988t C208(1.90); C201(1.28)  LDD1360  [1]
 LDCM0482  CL88 PaTu 8988t C208(1.70); C201(1.19)  LDD1361  [1]
 LDCM0483  CL89 PaTu 8988t C208(1.72); C201(1.63)  LDD1362  [1]
 LDCM0484  CL9 PaTu 8988t C208(1.81); C201(1.07)  LDD1363  [1]
 LDCM0485  CL90 PaTu 8988t C208(1.90); C201(1.22)  LDD1364  [1]
 LDCM0486  CL91 PaTu 8988t C208(0.91); C201(0.11)  LDD1365  [1]
 LDCM0487  CL92 PaTu 8988t C208(1.05); C201(0.14)  LDD1366  [1]
 LDCM0488  CL93 PaTu 8988t C208(1.14); C201(0.14)  LDD1367  [1]
 LDCM0489  CL94 PaTu 8988t C208(1.13); C201(0.11)  LDD1368  [1]
 LDCM0490  CL95 PaTu 8988t C208(1.71); C201(0.13)  LDD1369  [1]
 LDCM0491  CL96 PaTu 8988t C208(1.03); C201(0.13)  LDD1370  [1]
 LDCM0492  CL97 PaTu 8988t C208(0.94); C201(0.13)  LDD1371  [1]
 LDCM0493  CL98 PaTu 8988t C208(1.37); C201(0.15)  LDD1372  [1]
 LDCM0494  CL99 PaTu 8988t C208(1.13); C201(0.13)  LDD1373  [1]
 LDCM0468  Fragment33 PaTu 8988t C208(1.42); C201(1.65)  LDD1347  [1]
 LDCM0427  Fragment51 PaTu 8988t C208(1.54); C201(1.29)  LDD1306  [1]
 LDCM0022  KB02 22RV1 C208(3.23)  LDD2243  [5]
 LDCM0023  KB03 22RV1 C208(1.36)  LDD2660  [5]
 LDCM0024  KB05 HMCB C208(2.09)  LDD3312  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Beta-2 adrenergic receptor (ADRB2) G-protein coupled receptor 1 family P07550

The Drug(s) Related To This Target

Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Abx-1431 . D0CW8S
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Jzl184 Small molecular drug D0G0MZ
Patented
Click To Hide/Show 45 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Azetidine-benzoxazin-3(4h)-one Derivative 1 Small molecular drug D0J0UC
Azetidine-benzoxazin-3(4h)-one Derivative 2 Small molecular drug D0S9MR
Azetidine-benzoxazin-3(4h)-one Derivative 3 Small molecular drug D0VS7X
Azetidinyl-piperazine Derivative 1 Small molecular drug D0B5BT
Azetidinyl-piperazine Derivative 2 Small molecular drug D0OK3K
Azetidinyl-piperazine Derivative 3 Small molecular drug D00KFI
Azetidinyl-piperidine Derivative 1 Small molecular drug D00PFS
Azetidinyl-piperidine Derivative 2 Small molecular drug D0VY7R
Azetidinyl-piperidine Derivative 3 Small molecular drug D05SWA
Carbamate Derivative 10 Small molecular drug D0Y7LM
Carbamate Derivative 11 Small molecular drug D0Q4OB
Carbamate Derivative 12 Small molecular drug D0NK4T
Carbamate Derivative 13 Small molecular drug D0C5SQ
Carbamate Derivative 14 Small molecular drug D0FK7E
Carbamate Derivative 15 Small molecular drug D08EMW
Carbamate Derivative 16 Small molecular drug D05DBG
Carbamate Derivative 17 Small molecular drug D08SMT
Carbamate Derivative 9 Small molecular drug D0L6XG
Carbamide Derivative 24 Small molecular drug D00IPI
Carbamide Derivative 25 Small molecular drug D09RGE
Carbamide Derivative 26 Small molecular drug D02ZUW
Piperazine Carbamic Compound 1 Small molecular drug D0J6TA
Piperazine Carbamic Compound 2 Small molecular drug D0LC5Y
Piperazine Carbamic Compound 3 Small molecular drug D09LAD
Piperazine Carbamic Compound 4 Small molecular drug D00TVG
Piperazine Carbamic Compound 5 Small molecular drug D0Z7FL
Pmid29053063-compound-11c Small molecular drug D0TU6D
Pmid29053063-compound-11d Small molecular drug D0GT0I
Pmid29053063-compound-14 Small molecular drug D0V7PO
Pmid29053063-compound-15 Small molecular drug D0TL1G
Pmid29053063-compound-17 Small molecular drug D0G9NQ
Pmid29053063-compound-4 Small molecular drug D0UW6S
Pmid29053063-compound-5 Small molecular drug D07YWE
Pmid29053063-compound-7a Small molecular drug D03LKM
Pmid29053063-compound-7b Small molecular drug D03HHN
Pmid29053063-compound-7c Small molecular drug D0TT7U
Pmid29053063-compound-7d Small molecular drug D0D2YG
Pmid29053063-compound-7e Small molecular drug D0TW7K
Pmid29053063-compound-7f Small molecular drug D00VBP
Pyrazole Derivative 80 Small molecular drug D0X9GC
Pyrazole Derivative 81 Small molecular drug D0O9DS
Pyrazole Derivative 82 Small molecular drug D0LL0X
Pyrazole Derivative 83 Small molecular drug D0S2JF
Pyrazole Derivative 84 Small molecular drug D0YM0G
Pyrazole Derivative 85 Small molecular drug D04ZEX

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 Sequence-Based Prediction of Cysteine Reactivity Using Machine Learning. Biochemistry. 2018 Jan 30;57(4):451-460. doi: 10.1021/acs.biochem.7b00897. Epub 2017 Oct 26.
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840