Details of the Target

General Information of Target

Target ID LDTP10644
Target Name Crossover junction endonuclease MUS81 (MUS81)
Gene Name MUS81
Gene ID 80198
Synonyms
Crossover junction endonuclease MUS81; EC 3.1.22.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPLSLGAEMWGPEAWLLLLLLLASFTGRCPAGELETSDVVTVVLGQDAKLPCFYRGDSGE
QVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQA
DEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPALEEGQGLTLAASCTAEGSPAPS
VTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHIL
HVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRVDGDTL
GFPPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLDPQEDSGKQVDLVSASVVVVGVIAALL
FCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHTDPRSQPEESVGLRA
EGHPDSLKDNSSCSVMSEEPEGRSYSTLTTVREIETQTELLSPGSGRAEEEEDQDEGIKQ
AMNHFVQENGTLRAKPTGNGIYINGRGHLV
Target Bioclass
Enzyme
Family
XPF family
Subcellular location
Nucleus, nucleolus
Function
Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. Plays an essential role in mitosis for the processing of stalled or collapsed replication forks.
Uniprot ID
Q96NY9
Ensemble ID
ENST00000308110.9
HGNC ID
HGNC:29814

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C74(5.31)  LDD1706  [1]
DBIA
 Probe Info  		C74(0.92)  LDD0078  [2]
IPM
 Probe Info  		N.A.  LDD0025  [3]
NAIA_4
 Probe Info  		N.A.  LDD2226  [4]
TFBX
 Probe Info  		C16(0.00); C74(0.00)  LDD0148  [3]
Acrolein
 Probe Info  		C341(0.00); C510(0.00)  LDD0217  [5]
NAIA_5
 Probe Info  		N.A.  LDD2223  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C74(0.96)  LDD0531  [2]
 LDCM0215  AC10 HEK-293T C74(1.13)  LDD1508  [6]
 LDCM0216  AC100 HCT 116 C74(1.08)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C74(1.15)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C74(1.04)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C74(1.13)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C74(1.13)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C74(1.15)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C74(1.10)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C74(1.11)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C74(1.12)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C74(1.05)  LDD0542  [2]
 LDCM0226  AC11 HEK-293T C74(1.03)  LDD1509  [6]
 LDCM0227  AC110 HCT 116 C74(1.09)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C74(1.23)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C74(1.15)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C74(0.96)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C74(1.02)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C74(1.17)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C74(1.12)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C74(1.03)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C74(1.02)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C74(1.11)  LDD0553  [2]
 LDCM0237  AC12 HEK-293T C74(1.12); C16(1.01)  LDD1510  [6]
 LDCM0238  AC120 HCT 116 C74(1.10)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C74(1.03)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C74(1.16)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C74(1.00)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C74(1.01)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C74(0.99)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C74(1.21)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C74(1.16)  LDD0562  [2]
 LDCM0259  AC14 HEK-293T C16(0.98)  LDD1512  [6]
 LDCM0263  AC143 HEK-293T C74(1.02)  LDD0861  [2]
 LDCM0264  AC144 HEK-293T C74(0.90)  LDD0862  [2]
 LDCM0265  AC145 HEK-293T C74(0.91)  LDD0863  [2]
 LDCM0266  AC146 HEK-293T C74(1.06)  LDD0864  [2]
 LDCM0267  AC147 HEK-293T C74(0.82)  LDD0865  [2]
 LDCM0268  AC148 HEK-293T C74(1.05)  LDD0866  [2]
 LDCM0269  AC149 HEK-293T C74(0.88)  LDD0867  [2]
 LDCM0270  AC15 HEK-293T C74(1.12)  LDD1513  [6]
 LDCM0271  AC150 HEK-293T C74(0.89)  LDD0869  [2]
 LDCM0272  AC151 HEK-293T C74(0.94)  LDD0870  [2]
 LDCM0273  AC152 HEK-293T C74(0.99)  LDD0871  [2]
 LDCM0274  AC153 HEK-293T C74(0.84)  LDD0872  [2]
 LDCM0621  AC154 HEK-293T C74(0.82)  LDD2162  [2]
 LDCM0622  AC155 HEK-293T C74(1.23)  LDD2163  [2]
 LDCM0623  AC156 HEK-293T C74(0.94)  LDD2164  [2]
 LDCM0624  AC157 HEK-293T C74(0.71)  LDD2165  [2]
 LDCM0277  AC18 HEK-293T C74(1.03)  LDD1516  [6]
 LDCM0278  AC19 HEK-293T C74(1.04)  LDD1517  [6]
 LDCM0279  AC2 HCT 116 C74(0.87)  LDD0596  [2]
 LDCM0280  AC20 HEK-293T C74(1.05); C16(0.96)  LDD1519  [6]
 LDCM0281  AC21 HEK-293T C16(1.03)  LDD1520  [6]
 LDCM0282  AC22 HEK-293T C16(0.94)  LDD1521  [6]
 LDCM0283  AC23 HEK-293T C74(1.07)  LDD1522  [6]
 LDCM0284  AC24 HEK-293T C74(1.05)  LDD1523  [6]
 LDCM0286  AC26 HEK-293T C74(1.03)  LDD1525  [6]
 LDCM0287  AC27 HEK-293T C74(0.98)  LDD1526  [6]
 LDCM0288  AC28 HEK-293T C74(1.06); C16(0.98)  LDD1527  [6]
 LDCM0289  AC29 HEK-293T C16(0.95)  LDD1528  [6]
 LDCM0290  AC3 HCT 116 C74(0.92)  LDD0607  [2]
 LDCM0291  AC30 HEK-293T C16(1.02)  LDD1530  [6]
 LDCM0292  AC31 HEK-293T C74(1.13)  LDD1531  [6]
 LDCM0293  AC32 HEK-293T C74(1.01)  LDD1532  [6]
 LDCM0295  AC34 HEK-293T C74(1.05)  LDD1534  [6]
 LDCM0296  AC35 HEK-293T C74(1.02)  LDD1535  [6]
 LDCM0297  AC36 HEK-293T C74(1.13); C16(1.04)  LDD1536  [6]
 LDCM0298  AC37 HEK-293T C16(0.99)  LDD1537  [6]
 LDCM0299  AC38 HEK-293T C16(1.03)  LDD1538  [6]
 LDCM0300  AC39 HEK-293T C74(1.10)  LDD1539  [6]
 LDCM0301  AC4 HCT 116 C74(0.95)  LDD0618  [2]
 LDCM0302  AC40 HEK-293T C74(0.97)  LDD1541  [6]
 LDCM0304  AC42 HEK-293T C74(1.06)  LDD1543  [6]
 LDCM0305  AC43 HEK-293T C74(1.01)  LDD1544  [6]
 LDCM0306  AC44 HEK-293T C74(1.15); C16(1.09)  LDD1545  [6]
 LDCM0307  AC45 HEK-293T C16(0.96)  LDD1546  [6]
 LDCM0308  AC46 HEK-293T C16(0.98)  LDD1547  [6]
 LDCM0309  AC47 HEK-293T C74(1.15)  LDD1548  [6]
 LDCM0310  AC48 HEK-293T C74(1.09)  LDD1549  [6]
 LDCM0312  AC5 HCT 116 C74(0.99)  LDD0629  [2]
 LDCM0313  AC50 HEK-293T C74(1.15)  LDD1552  [6]
 LDCM0314  AC51 HEK-293T C74(0.97)  LDD1553  [6]
 LDCM0315  AC52 HEK-293T C74(1.13); C16(1.06)  LDD1554  [6]
 LDCM0316  AC53 HEK-293T C16(0.93)  LDD1555  [6]
 LDCM0317  AC54 HEK-293T C16(1.08)  LDD1556  [6]
 LDCM0318  AC55 HEK-293T C74(1.12)  LDD1557  [6]
 LDCM0319  AC56 HEK-293T C74(1.00)  LDD1558  [6]
 LDCM0321  AC58 HEK-293T C74(1.07)  LDD1560  [6]
 LDCM0322  AC59 HEK-293T C74(1.00)  LDD1561  [6]
 LDCM0323  AC6 HEK-293T C16(1.04)  LDD1562  [6]
 LDCM0324  AC60 HEK-293T C74(1.06); C16(1.13)  LDD1563  [6]
 LDCM0325  AC61 HEK-293T C16(1.00)  LDD1564  [6]
 LDCM0326  AC62 HEK-293T C16(1.00)  LDD1565  [6]
 LDCM0327  AC63 HEK-293T C74(1.10)  LDD1566  [6]
 LDCM0328  AC64 HEK-293T C74(0.89)  LDD1567  [6]
 LDCM0334  AC7 HEK-293T C74(1.12)  LDD1568  [6]
 LDCM0345  AC8 HEK-293T C74(0.97)  LDD1569  [6]
 LDCM0349  AC83 HCT 116 C74(1.12)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C74(1.04)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C74(1.03)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C74(1.18)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C74(1.22)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C74(1.41)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C74(1.29)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C74(1.14)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C74(1.08)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C74(1.13)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C74(1.02)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C74(1.26)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C74(1.30)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C74(1.29)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C74(1.09)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C74(1.32)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C74(1.03)  LDD0683  [2]
 LDCM0248  AKOS034007472 HEK-293T C16(1.03)  LDD1511  [6]
 LDCM0275  AKOS034007705 HEK-293T C74(1.13)  LDD1514  [6]
 LDCM0020  ARS-1620 HCC44 C74(0.92)  LDD0078  [2]
 LDCM0108  Chloroacetamide HeLa C341(0.00); C74(0.00)  LDD0222  [5]
 LDCM0367  CL1 HEK-293T C74(1.13)  LDD1571  [6]
 LDCM0368  CL10 HEK-293T C16(1.39)  LDD1572  [6]
 LDCM0369  CL100 HCT 116 C74(0.95)  LDD0686  [2]
 LDCM0370  CL101 HEK-293T C74(1.02)  LDD1574  [6]
 LDCM0371  CL102 HEK-293T C74(0.99); C16(1.12)  LDD1575  [6]
 LDCM0373  CL104 HEK-293T C74(0.95)  LDD1577  [6]
 LDCM0374  CL105 HEK-293T C74(1.11)  LDD1578  [6]
 LDCM0375  CL106 HEK-293T C74(0.97); C16(1.04)  LDD1579  [6]
 LDCM0377  CL108 HEK-293T C74(0.99)  LDD1581  [6]
 LDCM0378  CL109 HEK-293T C74(0.98)  LDD1582  [6]
 LDCM0379  CL11 HEK-293T C74(1.21)  LDD1583  [6]
 LDCM0380  CL110 HEK-293T C74(0.92); C16(1.03)  LDD1584  [6]
 LDCM0382  CL112 HEK-293T C74(0.94)  LDD1586  [6]
 LDCM0383  CL113 HEK-293T C74(1.13)  LDD1587  [6]
 LDCM0384  CL114 HEK-293T C74(0.97); C16(1.05)  LDD1588  [6]
 LDCM0386  CL116 HEK-293T C74(1.03)  LDD1590  [6]
 LDCM0387  CL117 HEK-293T C74(1.17)  LDD1591  [6]
 LDCM0388  CL118 HEK-293T C74(1.06); C16(0.96)  LDD1592  [6]
 LDCM0390  CL12 HEK-293T C74(1.13)  LDD1594  [6]
 LDCM0391  CL120 HEK-293T C74(1.02)  LDD1595  [6]
 LDCM0392  CL121 HEK-293T C74(1.08)  LDD1596  [6]
 LDCM0393  CL122 HEK-293T C74(1.03); C16(1.03)  LDD1597  [6]
 LDCM0395  CL124 HEK-293T C74(1.07)  LDD1599  [6]
 LDCM0396  CL125 HEK-293T C74(1.24)  LDD1600  [6]
 LDCM0397  CL126 HEK-293T C74(0.99); C16(1.10)  LDD1601  [6]
 LDCM0399  CL128 HEK-293T C74(0.98)  LDD1603  [6]
 LDCM0400  CL13 HEK-293T C74(0.98)  LDD1604  [6]
 LDCM0401  CL14 HEK-293T C74(1.03); C16(1.24)  LDD1605  [6]
 LDCM0403  CL16 HCT 116 C74(1.10)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C74(0.88)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C74(1.13)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C74(1.03)  LDD0723  [2]
 LDCM0407  CL2 HEK-293T C74(1.06); C16(1.29)  LDD1611  [6]
 LDCM0408  CL20 HCT 116 C74(0.98)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C74(1.06)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C74(1.27)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C74(1.11)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C74(1.06)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C74(1.36)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C74(1.15)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C74(1.11)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C74(1.04)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C74(1.02)  LDD0734  [2]
 LDCM0419  CL30 HCT 116 C74(1.09)  LDD0736  [2]
 LDCM0420  CL31 HEK-293T C74(1.01)  LDD1624  [6]
 LDCM0421  CL32 HEK-293T C74(1.08); C16(1.08)  LDD1625  [6]
 LDCM0422  CL33 HEK-293T C16(1.45)  LDD1626  [6]
 LDCM0423  CL34 HEK-293T C16(1.07)  LDD1627  [6]
 LDCM0424  CL35 HEK-293T C74(1.06)  LDD1628  [6]
 LDCM0425  CL36 HEK-293T C74(0.99)  LDD1629  [6]
 LDCM0426  CL37 HEK-293T C74(1.15)  LDD1630  [6]
 LDCM0429  CL4 HEK-293T C74(1.05)  LDD1633  [6]
 LDCM0430  CL40 HEK-293T C74(1.08)  LDD1634  [6]
 LDCM0432  CL42 HEK-293T C74(1.16)  LDD1636  [6]
 LDCM0433  CL43 HEK-293T C74(1.02)  LDD1637  [6]
 LDCM0434  CL44 HEK-293T C74(1.08); C16(1.05)  LDD1638  [6]
 LDCM0435  CL45 HEK-293T C16(1.22)  LDD1639  [6]
 LDCM0436  CL46 HEK-293T C74(0.87)  LDD1034  [2]
 LDCM0437  CL47 HEK-293T C74(0.90)  LDD1035  [2]
 LDCM0438  CL48 HEK-293T C74(0.94)  LDD1036  [2]
 LDCM0439  CL49 HEK-293T C74(0.95)  LDD1037  [2]
 LDCM0441  CL50 HEK-293T C74(0.78)  LDD1039  [2]
 LDCM0442  CL51 HEK-293T C74(0.85)  LDD1040  [2]
 LDCM0443  CL52 HEK-293T C74(1.02)  LDD1041  [2]
 LDCM0444  CL53 HEK-293T C74(0.93)  LDD1042  [2]
 LDCM0445  CL54 HEK-293T C74(0.92)  LDD1043  [2]
 LDCM0446  CL55 HEK-293T C74(0.88)  LDD1044  [2]
 LDCM0447  CL56 HEK-293T C74(1.00)  LDD1045  [2]
 LDCM0448  CL57 HEK-293T C74(0.95)  LDD1046  [2]
 LDCM0449  CL58 HEK-293T C74(1.05)  LDD1047  [2]
 LDCM0450  CL59 HEK-293T C74(1.03)  LDD1048  [2]
 LDCM0451  CL6 HEK-293T C74(1.06)  LDD1654  [6]
 LDCM0452  CL60 HEK-293T C74(0.99)  LDD1050  [2]
 LDCM0453  CL61 HEK-293T C74(0.94)  LDD1051  [2]
 LDCM0454  CL62 HEK-293T C74(0.94)  LDD1052  [2]
 LDCM0455  CL63 HEK-293T C74(0.96)  LDD1053  [2]
 LDCM0456  CL64 HEK-293T C74(1.09)  LDD1054  [2]
 LDCM0457  CL65 HEK-293T C74(1.00)  LDD1055  [2]
 LDCM0458  CL66 HEK-293T C74(1.01)  LDD1056  [2]
 LDCM0459  CL67 HEK-293T C74(1.03)  LDD1057  [2]
 LDCM0460  CL68 HEK-293T C74(0.95)  LDD1058  [2]
 LDCM0461  CL69 HEK-293T C74(0.89)  LDD1059  [2]
 LDCM0462  CL7 HEK-293T C74(1.11)  LDD1665  [6]
 LDCM0463  CL70 HEK-293T C74(1.03)  LDD1061  [2]
 LDCM0464  CL71 HEK-293T C74(0.89)  LDD1062  [2]
 LDCM0465  CL72 HEK-293T C74(0.94)  LDD1063  [2]
 LDCM0466  CL73 HEK-293T C74(0.92)  LDD1064  [2]
 LDCM0467  CL74 HEK-293T C74(0.89)  LDD1065  [2]
 LDCM0469  CL76 HEK-293T C74(1.02)  LDD1672  [6]
 LDCM0471  CL78 HEK-293T C74(1.05)  LDD1674  [6]
 LDCM0472  CL79 HEK-293T C74(1.01)  LDD1675  [6]
 LDCM0473  CL8 HEK-293T C74(1.10); C16(1.96)  LDD1676  [6]
 LDCM0474  CL80 HEK-293T C74(1.11); C16(1.03)  LDD1677  [6]
 LDCM0475  CL81 HEK-293T C16(0.92)  LDD1678  [6]
 LDCM0476  CL82 HEK-293T C16(0.94)  LDD1679  [6]
 LDCM0477  CL83 HEK-293T C74(1.08)  LDD1680  [6]
 LDCM0478  CL84 HEK-293T C74(0.94)  LDD1681  [6]
 LDCM0479  CL85 HEK-293T C74(1.15)  LDD1682  [6]
 LDCM0480  CL86 HEK-293T C74(0.93); C16(1.03)  LDD1683  [6]
 LDCM0482  CL88 HEK-293T C74(0.99)  LDD1685  [6]
 LDCM0484  CL9 HEK-293T C16(0.90)  LDD1687  [6]
 LDCM0485  CL90 HEK-293T C74(0.94)  LDD1688  [6]
 LDCM0486  CL91 HCT 116 C74(1.08)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C74(0.84)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C74(1.05)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C74(0.90)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C74(0.81)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C74(0.93)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C74(0.83)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C74(1.06)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C74(0.83)  LDD0811  [2]
 LDCM0625  F8 Ramos C74(0.89)  LDD2187  [7]
 LDCM0573  Fragment11 Ramos C74(0.71)  LDD2190  [7]
 LDCM0586  Fragment28 Ramos C74(1.28)  LDD2198  [7]
 LDCM0468  Fragment33 HEK-293T C74(0.91)  LDD1066  [2]
 LDCM0427  Fragment51 HEK-293T C74(1.06); C16(0.94)  LDD1631  [6]
 LDCM0022  KB02 A2058 C74(2.91)  LDD2253  [8]
 LDCM0023  KB03 A2058 C74(6.55)  LDD2670  [8]
 LDCM0024  KB05 RKO C74(6.12)  LDD3407  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Crossover junction endonuclease EME1 (EME1) EME1/MMS4 family Q96AY2
Probable crossover junction endonuclease EME2 (EME2) EME1/MMS4 family A4GXA9
Flap endonuclease 1 (FEN1) XPG/RAD2 endonuclease family P39748
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Structure-specific endonuclease subunit SLX4 (SLX4) SLX4 family Q8IY92

References

1 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840