General Information of Target

Target ID LDTP10534
Target Name Kinesin-like protein KIF16B (KIF16B)
Gene Name KIF16B
Gene ID 55614
Synonyms
C20orf23; KIAA1590; SNX23; Kinesin-like protein KIF16B; Sorting nexin-23
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MADEDGEGIHPSAPHRNGGGGGGGGSGLHCAGNGGGGGGGPRVVRIVKSESGYGFNVRGQ
VSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDRILEVNHVNVEGATHKQVVDL
IRAGEKELILTVLSVPPHEADNLDPSDDSLGQSFYDYTEKQAVPISVPRYKHVEQNGEKF
VVYNVYMAGRQLCSKRYREFAILHQNLKREFANFTFPRLPGKWPFSLSEQQLDARRRGLE
EYLEKVCSIRVIGESDIMQEFLSESDENYNGVSDVELRVALPDGTTVTVRVKKNSTTDQV
YQAIAAKVGMDSTTVNYFALFEVISHSFVRKLAPNEFPHKLYIQNYTSAVPGTCLTIRKW
LFTTEEEILLNDNDLAVTYFFHQAVDDVKKGYIKAEEKSYQLQKLYEQRKMVMYLNMLRT
CEGYNEIIFPHCACDSRRKGHVITAISITHFKLHACTEEGQLENQVIAFEWDEMQRWDTD
EEGMAFCFEYARGEKKPRWVKIFTPYFNYMHECFERVFCELKWRKENIFQMARSQQRDVA
T
Target Bioclass
Transporter and channel
Family
TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family
Subcellular location
Cytoplasm, cytoskeleton
Function
Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development.
Uniprot ID
Q96L93
Ensemble ID
ENST00000354981.7
HGNC ID
HGNC:15869

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
GB1 SNV: p.F572L DBIA    Probe Info 
HCT116 SNV: p.R641C .
HCT15 SNV: p.S1313R .
HT1197 SNV: p.V98L .
MCC13 Substitution: p.A1059V DBIA    Probe Info 
MDAMB231 SNV: p.E1254K .
MEWO SNV: p.L323F DBIA    Probe Info 
NCIH1155 SNV: p.T478R .
RKO SNV: p.A413T DBIA    Probe Info 
SW403 SNV: p.E984D DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info 
N.A.  LDD0241  [1]
DBIA
 Probe Info 
C126(4.08)  LDD3310  [2]
AHL-Pu-1
 Probe Info 
C1141(6.27)  LDD0170  [3]
Acrolein
 Probe Info 
N.A.  LDD0226  [4]
CY4
 Probe Info 
E691(0.00); Q693(0.00)  LDD0247  [5]
IA-alkyne
 Probe Info 
N.A.  LDD0162  [6]
Lodoacetamide azide
 Probe Info 
N.A.  LDD0037  [7]
NAIA_5
 Probe Info 
C863(0.00); C1141(0.00)  LDD2225  [8]
TFBX
 Probe Info 
N.A.  LDD0148  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C1141(6.27)  LDD0170  [3]
 LDCM0026  4SU-RNA+native RNA DM93 C866(2.07)  LDD0171  [3]
 LDCM0214  AC1 HEK-293T C97(0.72)  LDD0812  [10]
 LDCM0215  AC10 HEK-293T C97(1.49)  LDD0813  [10]
 LDCM0216  AC100 PaTu 8988t C1194(1.19)  LDD1095  [10]
 LDCM0217  AC101 PaTu 8988t C1194(0.72)  LDD1096  [10]
 LDCM0218  AC102 PaTu 8988t C1194(0.90)  LDD1097  [10]
 LDCM0219  AC103 PaTu 8988t C1194(0.94)  LDD1098  [10]
 LDCM0220  AC104 PaTu 8988t C1194(0.75)  LDD1099  [10]
 LDCM0221  AC105 PaTu 8988t C1194(0.73)  LDD1100  [10]
 LDCM0222  AC106 PaTu 8988t C1194(1.45)  LDD1101  [10]
 LDCM0223  AC107 PaTu 8988t C1194(1.04)  LDD1102  [10]
 LDCM0224  AC108 PaTu 8988t C1194(1.31)  LDD1103  [10]
 LDCM0225  AC109 PaTu 8988t C1194(0.97)  LDD1104  [10]
 LDCM0226  AC11 HEK-293T C97(1.19)  LDD0824  [10]
 LDCM0227  AC110 PaTu 8988t C1194(0.96)  LDD1106  [10]
 LDCM0228  AC111 PaTu 8988t C1194(1.33)  LDD1107  [10]
 LDCM0229  AC112 PaTu 8988t C1194(1.03)  LDD1108  [10]
 LDCM0230  AC113 HEK-293T C97(1.17)  LDD0828  [10]
 LDCM0231  AC114 HEK-293T C97(1.01)  LDD0829  [10]
 LDCM0232  AC115 HEK-293T C97(0.92)  LDD0830  [10]
 LDCM0233  AC116 HEK-293T C97(1.09)  LDD0831  [10]
 LDCM0234  AC117 HEK-293T C97(1.07)  LDD0832  [10]
 LDCM0235  AC118 HEK-293T C97(1.35)  LDD0833  [10]
 LDCM0236  AC119 HEK-293T C97(1.33)  LDD0834  [10]
 LDCM0237  AC12 HEK-293T C97(1.25)  LDD0835  [10]
 LDCM0238  AC120 HEK-293T C97(1.09)  LDD0836  [10]
 LDCM0239  AC121 HEK-293T C97(1.20)  LDD0837  [10]
 LDCM0240  AC122 HEK-293T C97(1.17)  LDD0838  [10]
 LDCM0241  AC123 HEK-293T C97(1.07)  LDD0839  [10]
 LDCM0242  AC124 HEK-293T C97(1.13)  LDD0840  [10]
 LDCM0243  AC125 HEK-293T C97(1.49)  LDD0841  [10]
 LDCM0244  AC126 HEK-293T C97(1.27)  LDD0842  [10]
 LDCM0245  AC127 HEK-293T C97(1.37)  LDD0843  [10]
 LDCM0259  AC14 HEK-293T C97(1.38)  LDD0857  [10]
 LDCM0270  AC15 HEK-293T C97(1.45)  LDD0868  [10]
 LDCM0276  AC17 HEK-293T C97(0.87)  LDD0874  [10]
 LDCM0277  AC18 HEK-293T C97(0.78)  LDD0875  [10]
 LDCM0278  AC19 HEK-293T C97(0.77)  LDD0876  [10]
 LDCM0279  AC2 HEK-293T C97(1.06)  LDD0877  [10]
 LDCM0280  AC20 HEK-293T C97(0.95)  LDD0878  [10]
 LDCM0281  AC21 HEK-293T C97(0.76)  LDD0879  [10]
 LDCM0282  AC22 HEK-293T C97(0.68)  LDD0880  [10]
 LDCM0283  AC23 HEK-293T C97(0.92)  LDD0881  [10]
 LDCM0284  AC24 HEK-293T C97(0.74)  LDD0882  [10]
 LDCM0285  AC25 HEK-293T C1194(1.06); C1298(1.05)  LDD1524  [11]
 LDCM0286  AC26 HEK-293T C1194(0.86); C1298(1.09)  LDD1525  [11]
 LDCM0287  AC27 HEK-293T C1194(1.02); C242(1.01); C863(1.10); C1141(0.91)  LDD1526  [11]
 LDCM0288  AC28 HEK-293T C1194(0.98); C1298(1.03); C1141(0.94)  LDD1527  [11]
 LDCM0289  AC29 HEK-293T C1298(1.00); C242(0.94); C1141(0.85)  LDD1528  [11]
 LDCM0290  AC3 HEK-293T C97(0.96)  LDD0888  [10]
 LDCM0291  AC30 HEK-293T C1194(1.01)  LDD1530  [11]
 LDCM0292  AC31 HEK-293T C1194(0.95); C242(0.72)  LDD1531  [11]
 LDCM0293  AC32 HEK-293T C1298(1.06); C242(1.07)  LDD1532  [11]
 LDCM0294  AC33 HEK-293T C1194(1.09); C1298(1.07)  LDD1533  [11]
 LDCM0295  AC34 HEK-293T C1194(0.90); C1298(1.06)  LDD1534  [11]
 LDCM0296  AC35 HEK-293T C97(1.02)  LDD0894  [10]
 LDCM0297  AC36 HEK-293T C97(0.86)  LDD0895  [10]
 LDCM0298  AC37 HEK-293T C97(0.91)  LDD0896  [10]
 LDCM0299  AC38 HEK-293T C97(0.88)  LDD0897  [10]
 LDCM0300  AC39 HEK-293T C97(0.73)  LDD0898  [10]
 LDCM0301  AC4 HEK-293T C97(1.14)  LDD0899  [10]
 LDCM0302  AC40 HEK-293T C97(1.04)  LDD0900  [10]
 LDCM0303  AC41 HEK-293T C97(0.91)  LDD0901  [10]
 LDCM0304  AC42 HEK-293T C97(1.02)  LDD0902  [10]
 LDCM0305  AC43 HEK-293T C97(0.96)  LDD0903  [10]
 LDCM0306  AC44 HEK-293T C97(0.86)  LDD0904  [10]
 LDCM0307  AC45 HEK-293T C97(0.82)  LDD0905  [10]
 LDCM0308  AC46 PaTu 8988t C97(0.73); C1194(0.95)  LDD1187  [10]
 LDCM0309  AC47 PaTu 8988t C97(0.62); C1194(0.98)  LDD1188  [10]
 LDCM0310  AC48 PaTu 8988t C97(0.61); C1194(0.99)  LDD1189  [10]
 LDCM0311  AC49 PaTu 8988t C97(0.54); C1194(1.00)  LDD1190  [10]
 LDCM0312  AC5 HEK-293T C97(1.28)  LDD0910  [10]
 LDCM0313  AC50 PaTu 8988t C97(0.56); C1194(1.05)  LDD1192  [10]
 LDCM0314  AC51 PaTu 8988t C97(0.44); C1194(0.48)  LDD1193  [10]
 LDCM0315  AC52 PaTu 8988t C97(0.53); C1194(0.93)  LDD1194  [10]
 LDCM0316  AC53 PaTu 8988t C97(0.62); C1194(1.10)  LDD1195  [10]
 LDCM0317  AC54 PaTu 8988t C97(0.59); C1194(1.20)  LDD1196  [10]
 LDCM0318  AC55 PaTu 8988t C97(0.64); C1194(1.03)  LDD1197  [10]
 LDCM0319  AC56 PaTu 8988t C97(0.79); C1194(1.06)  LDD1198  [10]
 LDCM0320  AC57 HEK-293T C97(1.04)  LDD0918  [10]
 LDCM0321  AC58 HEK-293T C97(0.91)  LDD0919  [10]
 LDCM0322  AC59 HEK-293T C97(0.99)  LDD0920  [10]
 LDCM0323  AC6 HEK-293T C97(1.11)  LDD0921  [10]
 LDCM0324  AC60 HEK-293T C97(0.72)  LDD0922  [10]
 LDCM0325  AC61 HEK-293T C97(1.02)  LDD0923  [10]
 LDCM0326  AC62 HEK-293T C97(0.91)  LDD0924  [10]
 LDCM0327  AC63 HEK-293T C97(1.00)  LDD0925  [10]
 LDCM0328  AC64 HEK-293T C97(0.98)  LDD0926  [10]
 LDCM0329  AC65 HEK-293T C97(1.10)  LDD0927  [10]
 LDCM0330  AC66 HEK-293T C97(1.00)  LDD0928  [10]
 LDCM0331  AC67 HEK-293T C97(1.14)  LDD0929  [10]
 LDCM0334  AC7 HEK-293T C97(0.99)  LDD0932  [10]
 LDCM0345  AC8 HEK-293T C97(1.45)  LDD0943  [10]
 LDCM0349  AC83 HEK-293T C97(1.02)  LDD0947  [10]
 LDCM0350  AC84 HEK-293T C97(0.96)  LDD0948  [10]
 LDCM0351  AC85 HEK-293T C97(0.95)  LDD0949  [10]
 LDCM0352  AC86 HEK-293T C97(1.05)  LDD0950  [10]
 LDCM0353  AC87 HEK-293T C97(1.08)  LDD0951  [10]
 LDCM0354  AC88 HEK-293T C97(1.03)  LDD0952  [10]
 LDCM0355  AC89 HEK-293T C97(1.15)  LDD0953  [10]
 LDCM0357  AC90 HEK-293T C97(1.08)  LDD0955  [10]
 LDCM0358  AC91 HEK-293T C97(1.10)  LDD0956  [10]
 LDCM0359  AC92 HEK-293T C97(0.98)  LDD0957  [10]
 LDCM0360  AC93 HEK-293T C97(1.09)  LDD0958  [10]
 LDCM0361  AC94 HEK-293T C97(1.24)  LDD0959  [10]
 LDCM0362  AC95 HEK-293T C97(0.99)  LDD0960  [10]
 LDCM0363  AC96 HEK-293T C97(1.06)  LDD0961  [10]
 LDCM0364  AC97 HEK-293T C97(1.65)  LDD0962  [10]
 LDCM0365  AC98 PaTu 8988t C1194(0.73)  LDD1244  [10]
 LDCM0366  AC99 PaTu 8988t C1194(1.51)  LDD1245  [10]
 LDCM0248  AKOS034007472 HEK-293T C97(1.19)  LDD0846  [10]
 LDCM0356  AKOS034007680 HEK-293T C97(1.54)  LDD0954  [10]
 LDCM0275  AKOS034007705 HEK-293T C97(1.41)  LDD0873  [10]
 LDCM0632  CL-Sc Hep-G2 C1141(1.42)  LDD2227  [8]
 LDCM0367  CL1 HEK-293T C1194(1.10)  LDD1571  [11]
 LDCM0368  CL10 HEK-293T C1194(1.10)  LDD1572  [11]
 LDCM0369  CL100 HEK-293T C97(1.20)  LDD0967  [10]
 LDCM0370  CL101 HEK-293T C97(1.64)  LDD0968  [10]
 LDCM0371  CL102 HEK-293T C97(1.47)  LDD0969  [10]
 LDCM0372  CL103 HEK-293T C97(1.44)  LDD0970  [10]
 LDCM0373  CL104 HEK-293T C97(1.37)  LDD0971  [10]
 LDCM0374  CL105 HEK-293T C97(0.67)  LDD0972  [10]
 LDCM0375  CL106 HEK-293T C97(0.66)  LDD0973  [10]
 LDCM0376  CL107 HEK-293T C97(0.84)  LDD0974  [10]
 LDCM0377  CL108 HEK-293T C97(0.69)  LDD0975  [10]
 LDCM0378  CL109 HEK-293T C97(0.75)  LDD0976  [10]
 LDCM0379  CL11 HEK-293T C1194(1.13); C242(1.01)  LDD1583  [11]
 LDCM0380  CL110 HEK-293T C97(0.79)  LDD0978  [10]
 LDCM0381  CL111 HEK-293T C97(0.92)  LDD0979  [10]
 LDCM0382  CL112 HEK-293T C1194(0.87); C1298(1.01); C863(0.94)  LDD1586  [11]
 LDCM0383  CL113 HEK-293T C1194(1.04)  LDD1587  [11]
 LDCM0384  CL114 HEK-293T C1298(1.07)  LDD1588  [11]
 LDCM0385  CL115 HEK-293T C1298(1.06); C242(1.01)  LDD1589  [11]
 LDCM0386  CL116 HEK-293T C1194(0.98); C1298(0.94); C863(0.93)  LDD1590  [11]
 LDCM0387  CL117 HEK-293T C97(0.72)  LDD0985  [10]
 LDCM0388  CL118 HEK-293T C97(0.70)  LDD0986  [10]
 LDCM0389  CL119 HEK-293T C97(0.97)  LDD0987  [10]
 LDCM0390  CL12 HEK-293T C1298(0.93); C242(1.09)  LDD1594  [11]
 LDCM0391  CL120 HEK-293T C97(0.77)  LDD0989  [10]
 LDCM0392  CL121 PaTu 8988t C97(0.66); C1194(1.07)  LDD1271  [10]
 LDCM0393  CL122 PaTu 8988t C97(1.03); C1194(0.91)  LDD1272  [10]
 LDCM0394  CL123 PaTu 8988t C97(0.54); C1194(1.06)  LDD1273  [10]
 LDCM0395  CL124 PaTu 8988t C97(0.50); C1194(1.08)  LDD1274  [10]
 LDCM0396  CL125 HEK-293T C97(1.07)  LDD0994  [10]
 LDCM0397  CL126 HEK-293T C97(0.96)  LDD0995  [10]
 LDCM0398  CL127 HEK-293T C97(0.97)  LDD0996  [10]
 LDCM0399  CL128 HEK-293T C97(1.01)  LDD0997  [10]
 LDCM0400  CL13 HEK-293T C1194(1.11)  LDD1604  [11]
 LDCM0401  CL14 HEK-293T C1298(1.07)  LDD1605  [11]
 LDCM0402  CL15 HEK-293T C1298(0.99); C242(1.13)  LDD1606  [11]
 LDCM0403  CL16 PaTu 8988t C1194(1.13)  LDD1282  [10]
 LDCM0404  CL17 PaTu 8988t C1194(1.07)  LDD1283  [10]
 LDCM0405  CL18 PaTu 8988t C1194(1.08)  LDD1284  [10]
 LDCM0406  CL19 PaTu 8988t C1194(1.24)  LDD1285  [10]
 LDCM0407  CL2 HEK-293T C1298(0.97)  LDD1611  [11]
 LDCM0408  CL20 PaTu 8988t C1194(1.34)  LDD1287  [10]
 LDCM0409  CL21 PaTu 8988t C1194(1.23)  LDD1288  [10]
 LDCM0410  CL22 PaTu 8988t C1194(1.24)  LDD1289  [10]
 LDCM0411  CL23 PaTu 8988t C1194(1.20)  LDD1290  [10]
 LDCM0412  CL24 PaTu 8988t C1194(1.22)  LDD1291  [10]
 LDCM0413  CL25 PaTu 8988t C1194(1.12)  LDD1292  [10]
 LDCM0414  CL26 PaTu 8988t C1194(1.16)  LDD1293  [10]
 LDCM0415  CL27 PaTu 8988t C1194(1.15)  LDD1294  [10]
 LDCM0416  CL28 PaTu 8988t C1194(1.55)  LDD1295  [10]
 LDCM0417  CL29 PaTu 8988t C1194(1.27)  LDD1296  [10]
 LDCM0418  CL3 HEK-293T C1298(0.99); C242(1.37)  LDD1622  [11]
 LDCM0419  CL30 PaTu 8988t C1194(1.20)  LDD1298  [10]
 LDCM0420  CL31 HEK-293T C97(0.85)  LDD1018  [10]
 LDCM0421  CL32 HEK-293T C97(1.12)  LDD1019  [10]
 LDCM0422  CL33 HEK-293T C97(1.11)  LDD1020  [10]
 LDCM0423  CL34 HEK-293T C97(1.00)  LDD1021  [10]
 LDCM0424  CL35 HEK-293T C97(0.79)  LDD1022  [10]
 LDCM0425  CL36 HEK-293T C97(0.90)  LDD1023  [10]
 LDCM0426  CL37 HEK-293T C97(0.89)  LDD1024  [10]
 LDCM0428  CL39 HEK-293T C97(1.32)  LDD1026  [10]
 LDCM0429  CL4 HEK-293T C1194(1.04); C1298(0.96); C863(0.97)  LDD1633  [11]
 LDCM0430  CL40 HEK-293T C97(1.06)  LDD1028  [10]
 LDCM0431  CL41 HEK-293T C97(1.04)  LDD1029  [10]
 LDCM0432  CL42 HEK-293T C97(0.98)  LDD1030  [10]
 LDCM0433  CL43 HEK-293T C97(1.00)  LDD1031  [10]
 LDCM0434  CL44 HEK-293T C97(0.98)  LDD1032  [10]
 LDCM0435  CL45 HEK-293T C97(1.17)  LDD1033  [10]
 LDCM0436  CL46 HEK-293T C97(1.01)  LDD1034  [10]
 LDCM0437  CL47 HEK-293T C97(0.91)  LDD1035  [10]
 LDCM0438  CL48 HEK-293T C97(1.00)  LDD1036  [10]
 LDCM0439  CL49 HEK-293T C97(1.07)  LDD1037  [10]
 LDCM0440  CL5 HEK-293T C1194(1.28); C1298(1.03)  LDD1644  [11]
 LDCM0441  CL50 HEK-293T C97(1.21)  LDD1039  [10]
 LDCM0442  CL51 HEK-293T C97(1.11)  LDD1040  [10]
 LDCM0443  CL52 HEK-293T C97(0.87)  LDD1041  [10]
 LDCM0444  CL53 HEK-293T C97(0.83)  LDD1042  [10]
 LDCM0445  CL54 HEK-293T C97(0.94)  LDD1043  [10]
 LDCM0446  CL55 HEK-293T C97(0.95)  LDD1044  [10]
 LDCM0447  CL56 HEK-293T C97(0.80)  LDD1045  [10]
 LDCM0448  CL57 HEK-293T C97(1.06)  LDD1046  [10]
 LDCM0449  CL58 HEK-293T C97(0.98)  LDD1047  [10]
 LDCM0450  CL59 HEK-293T C97(0.93)  LDD1048  [10]
 LDCM0451  CL6 HEK-293T C1194(0.90); C1298(1.11)  LDD1654  [11]
 LDCM0452  CL60 HEK-293T C97(1.46)  LDD1050  [10]
 LDCM0453  CL61 PaTu 8988t C97(0.93); C1194(1.05)  LDD1332  [10]
 LDCM0454  CL62 PaTu 8988t C97(0.72); C1194(1.05)  LDD1333  [10]
 LDCM0455  CL63 PaTu 8988t C97(0.69); C1194(1.05)  LDD1334  [10]
 LDCM0456  CL64 PaTu 8988t C97(0.60); C1194(1.02)  LDD1335  [10]
 LDCM0457  CL65 PaTu 8988t C97(0.78); C1194(1.04)  LDD1336  [10]
 LDCM0458  CL66 PaTu 8988t C97(0.65); C1194(1.12)  LDD1337  [10]
 LDCM0459  CL67 PaTu 8988t C97(0.72); C1194(1.17)  LDD1338  [10]
 LDCM0460  CL68 PaTu 8988t C97(0.61); C1194(1.15)  LDD1339  [10]
 LDCM0461  CL69 PaTu 8988t C97(0.54); C1194(1.26)  LDD1340  [10]
 LDCM0462  CL7 HEK-293T C1194(1.12); C242(1.11); C863(1.14); C1141(1.27)  LDD1665  [11]
 LDCM0463  CL70 PaTu 8988t C97(0.65); C1194(1.17)  LDD1342  [10]
 LDCM0464  CL71 PaTu 8988t C97(0.82); C1194(1.04)  LDD1343  [10]
 LDCM0465  CL72 PaTu 8988t C97(0.76); C1194(1.03)  LDD1344  [10]
 LDCM0466  CL73 PaTu 8988t C97(0.72); C1194(1.14)  LDD1345  [10]
 LDCM0467  CL74 PaTu 8988t C97(0.76); C1194(1.05)  LDD1346  [10]
 LDCM0469  CL76 HEK-293T C97(0.92)  LDD1067  [10]
 LDCM0470  CL77 HEK-293T C97(0.76)  LDD1068  [10]
 LDCM0471  CL78 HEK-293T C97(0.65)  LDD1069  [10]
 LDCM0472  CL79 HEK-293T C97(0.82)  LDD1070  [10]
 LDCM0473  CL8 HEK-293T C1194(0.98); C1298(0.62); C1141(0.88)  LDD1676  [11]
 LDCM0474  CL80 HEK-293T C97(0.84)  LDD1072  [10]
 LDCM0475  CL81 HEK-293T C97(0.88)  LDD1073  [10]
 LDCM0476  CL82 HEK-293T C97(1.27)  LDD1074  [10]
 LDCM0477  CL83 HEK-293T C97(1.12)  LDD1075  [10]
 LDCM0478  CL84 HEK-293T C97(0.99)  LDD1076  [10]
 LDCM0479  CL85 HEK-293T C97(0.88)  LDD1077  [10]
 LDCM0480  CL86 HEK-293T C97(0.77)  LDD1078  [10]
 LDCM0481  CL87 HEK-293T C97(0.98)  LDD1079  [10]
 LDCM0482  CL88 HEK-293T C97(0.94)  LDD1080  [10]
 LDCM0483  CL89 HEK-293T C97(0.87)  LDD1081  [10]
 LDCM0484  CL9 HEK-293T C1298(1.02); C242(0.95); C1141(1.09)  LDD1687  [11]
 LDCM0485  CL90 HEK-293T C97(1.28)  LDD1083  [10]
 LDCM0486  CL91 HEK-293T C97(1.18)  LDD1084  [10]
 LDCM0487  CL92 HEK-293T C97(1.09)  LDD1085  [10]
 LDCM0488  CL93 HEK-293T C97(1.05)  LDD1086  [10]
 LDCM0489  CL94 HEK-293T C97(1.65)  LDD1087  [10]
 LDCM0490  CL95 HEK-293T C97(1.29)  LDD1088  [10]
 LDCM0491  CL96 HEK-293T C97(1.23)  LDD1089  [10]
 LDCM0492  CL97 HEK-293T C97(1.18)  LDD1090  [10]
 LDCM0493  CL98 HEK-293T C97(1.23)  LDD1091  [10]
 LDCM0494  CL99 HEK-293T C97(1.13)  LDD1092  [10]
 LDCM0495  E2913 HEK-293T C1298(1.12); C242(1.31)  LDD1698  [11]
 LDCM0468  Fragment33 PaTu 8988t C97(0.64); C1194(1.15)  LDD1347  [10]
 LDCM0427  Fragment51 HEK-293T C97(1.00)  LDD1025  [10]
 LDCM0022  KB02 22RV1 C126(2.82)  LDD2243  [2]
 LDCM0023  KB03 22RV1 C126(3.96)  LDD2660  [2]
 LDCM0024  KB05 COLO792 C126(4.08)  LDD3310  [2]
 LDCM0109  NEM HeLa N.A.  LDD0226  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone-lysine N-methyltransferase SMYD1 (SMYD1) Class V-like SAM-binding methyltransferase superfamily Q8NB12
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2) CAMK Ser/Thr protein kinase family P54646
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Galectin-3 (LGALS3) . P17931
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gamma-aminobutyric acid receptor-associated protein-like 2 (GABARAPL2) ATG8 family P60520
DNA replication complex GINS protein SLD5 (GINS4) GINS4/SLD5 family Q9BRT9
Pre-rRNA-processing protein TSR2 homolog (TSR2) TSR2 family Q969E8

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402