Details of the Target

General Information of Target

Target ID LDTP10522
Target Name WD repeat-containing protein 90 (WDR90)
Gene Name WDR90
Gene ID 197335
Synonyms
C16orf15; C16orf16; C16orf17; C16orf18; C16orf19; KIAA1924; WD repeat-containing protein 90
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDSPCQPQPLSQALPQLPGSSSEPLEPEPGRARMGVESYLPCPLLPSYHCPGVPSEASAG
SGTPRATATSTTASPLRDGFGGQDGGELRPLQSEGAAALVTKGCQRLAAQGARPEAPKRK
WAEDGGDAPSPSKRPWARQENQEAEREGGMSCSCSSGSGEASAGLMEEALPSAPERLALD
YIVPCMRYYGICVKDSFLGAALGGRVLAEVEALKRGGRLRDGQLVSQRAIPPRSIRGDQI
AWVEGHEPGCRSIGALMAHVDAVIRHCAGRLGSYVINGRTKAMVACYPGNGLGYVRHVDN
PHGDGRCITCIYYLNQNWDVKVHGGLLQIFPEGRPVVANIEPLFDRLLIFWSDRRNPHEV
KPAYATRYAITVWYFDAKERAAAKDKYQLASGQKGVQVPVSQPPTPT
Target Bioclass
Other
Family
WD repeat WDR90/POC16 family
Subcellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole
Function Required for efficient primary cilium formation.
Uniprot ID
Q96KV7
Ensemble ID
ENST00000293879.9
HGNC ID
HGNC:26960

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.V823M .
A498 SNV: p.A701S .
CAL148 SNV: p.R430S .
COLO792 SNV: p.P629Q .
DU145 SNV: p.V1409F .
HT1080 SNV: p.P1013L .
Ishikawa (Heraklio) 02 ER SNV: p.V1143A .
JURKAT Deletion: p.D669MfsTer122 .
MCC13 Substitution: p.T723I .
MEC1 SNV: p.G635S; p.L641S .
MOLT4 SNV: p.V778L; p.L1265F; p.A1339V .
RD SNV: p.H1168N .
RL952 SNV: p.C1316F .
SKNSH SNV: p.A1423D
Substitution: p.G1070A		 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C240(0.94); C257(0.94)  LDD0531  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C240(0.94); C257(0.94)  LDD0531  [1]
 LDCM0279  AC2 HCT 116 C240(1.01); C257(1.01)  LDD0596  [1]
 LDCM0290  AC3 HCT 116 C240(0.82); C257(0.82)  LDD0607  [1]
 LDCM0301  AC4 HCT 116 C240(0.87); C257(0.87)  LDD0618  [1]
 LDCM0312  AC5 HCT 116 C240(0.83); C257(0.83)  LDD0629  [1]
 LDCM0320  AC57 HCT 116 C240(1.15); C257(1.15)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C240(1.03); C257(1.03)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C240(1.19); C257(1.19)  LDD0639  [1]
 LDCM0324  AC60 HCT 116 C240(1.27); C257(1.27)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C240(1.15); C257(1.15)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C240(1.15); C257(1.15)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C240(1.41); C257(1.41)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C240(1.39); C257(1.39)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C240(1.29); C257(1.29)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C240(1.35); C257(1.35)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C240(1.51); C257(1.51)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C240(0.80); C257(0.80)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C240(0.65); C257(0.65)  LDD0650  [1]
 LDCM0335  AC70 HCT 116 C240(0.78); C257(0.78)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C240(0.68); C257(0.68)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C240(0.75); C257(0.75)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C240(0.85); C257(0.85)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C240(0.69); C257(0.69)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C240(0.88); C257(0.88)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C240(0.88); C257(0.88)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C240(0.86); C257(0.86)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C240(0.83); C257(0.83)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C240(0.83); C257(0.83)  LDD0661  [1]
 LDCM0346  AC80 HCT 116 C240(0.77); C257(0.77)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C240(0.64); C257(0.64)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C240(0.95); C257(0.95)  LDD0665  [1]
 LDCM0367  CL1 HCT 116 C240(1.27); C257(1.27)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C240(0.86); C257(0.86)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C240(1.09); C257(1.09)  LDD0686  [1]
 LDCM0379  CL11 HCT 116 C240(1.56); C257(1.56)  LDD0696  [1]
 LDCM0390  CL12 HCT 116 C240(0.86); C257(0.86)  LDD0707  [1]
 LDCM0396  CL125 HCT 116 C240(1.08); C257(1.08)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C240(1.24); C257(1.24)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C240(0.98); C257(0.98)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C240(1.05); C257(1.05)  LDD0716  [1]
 LDCM0400  CL13 HCT 116 C240(0.72); C257(0.72)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C240(0.96); C257(0.96)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C240(1.10); C257(1.10)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C240(1.11); C257(1.11)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C240(0.94); C257(0.94)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C240(0.84); C257(0.84)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C240(0.82); C257(0.82)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C240(1.09); C257(1.09)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C240(0.73); C257(0.73)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C240(1.13); C257(1.13)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C240(0.90); C257(0.90)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C240(0.98); C257(0.98)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C240(0.89); C257(0.89)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C240(0.82); C257(0.82)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C240(0.90); C257(0.90)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C240(0.76); C257(0.76)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C240(0.89); C257(0.89)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C240(0.91); C257(0.91)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C240(0.98); C257(0.98)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C240(0.79); C257(0.79)  LDD0736  [1]
 LDCM0421  CL32 HCT 116 C240(1.05); C257(1.05)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C240(2.44); C257(2.44)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C240(0.95); C257(0.95)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C240(0.86); C257(0.86)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C240(0.91); C257(0.91)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C240(0.95); C257(0.95)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C240(1.04); C257(1.04)  LDD0745  [1]
 LDCM0429  CL4 HCT 116 C240(0.87); C257(0.87)  LDD0746  [1]
 LDCM0430  CL40 HCT 116 C240(1.14); C257(1.14)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C240(1.16); C257(1.16)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C240(0.92); C257(0.92)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C240(1.12); C257(1.12)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C240(0.96); C257(0.96)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C240(0.88); C257(0.88)  LDD0752  [1]
 LDCM0436  CL46 HCT 116 C240(1.27); C257(1.27)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C240(0.86); C257(0.86)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C240(0.86); C257(0.86)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C240(1.01); C257(1.01)  LDD0756  [1]
 LDCM0440  CL5 HCT 116 C240(0.79); C257(0.79)  LDD0757  [1]
 LDCM0441  CL50 HCT 116 C240(0.96); C257(0.96)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C240(0.96); C257(0.96)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C240(1.21); C257(1.21)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C240(1.07); C257(1.07)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C240(0.98); C257(0.98)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C240(0.99); C257(0.99)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C240(0.89); C257(0.89)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C240(0.80); C257(0.80)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C240(1.12); C257(1.12)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C240(1.02); C257(1.02)  LDD0767  [1]
 LDCM0451  CL6 HCT 116 C240(0.96); C257(0.96)  LDD0768  [1]
 LDCM0452  CL60 HCT 116 C240(1.06); C257(1.06)  LDD0769  [1]
 LDCM0462  CL7 HCT 116 C240(0.76); C257(0.76)  LDD0779  [1]
 LDCM0469  CL76 HCT 116 C240(0.78); C257(0.78)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C240(0.72); C257(0.72)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C240(1.17); C257(1.17)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C240(0.99); C257(0.99)  LDD0789  [1]
 LDCM0473  CL8 HCT 116 C240(7.44); C257(7.44)  LDD0790  [1]
 LDCM0474  CL80 HCT 116 C240(0.98); C257(0.98)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C240(0.80); C257(0.80)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C240(0.81); C257(0.81)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C240(1.12); C257(1.12)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C240(1.15); C257(1.15)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C240(1.34); C257(1.34)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C240(0.92); C257(0.92)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C240(0.96); C257(0.96)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C240(0.79); C257(0.79)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C240(0.95); C257(0.95)  LDD0800  [1]
 LDCM0484  CL9 HCT 116 C240(0.86); C257(0.86)  LDD0801  [1]
 LDCM0485  CL90 HCT 116 C240(2.33); C257(2.33)  LDD0802  [1]
 LDCM0486  CL91 HCT 116 C240(1.07); C257(1.07)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C240(1.11); C257(1.11)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C240(0.89); C257(0.89)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C240(0.97); C257(0.97)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C240(1.35); C257(1.35)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C240(0.89); C257(0.89)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C240(0.88); C257(0.88)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C240(1.03); C257(1.03)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C240(1.04); C257(1.04)  LDD0811  [1]
 LDCM0427  Fragment51 HCT 116 C240(1.01); C257(1.01)  LDD0744  [1]
 LDCM0022  KB02 ICC20 C275(2.43)  LDD2387  [2]
 LDCM0023  KB03 ICC20 C275(2.65)  LDD2804  [2]
 LDCM0024  KB05 TGBC1TKB C275(2.29)  LDD3473  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
RNA-binding protein with multiple splicing (RBPMS) . Q93062

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840